CN109709316A - A kind of more target item miniflow test cards and preparation method - Google Patents
A kind of more target item miniflow test cards and preparation method Download PDFInfo
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- CN109709316A CN109709316A CN201811612545.2A CN201811612545A CN109709316A CN 109709316 A CN109709316 A CN 109709316A CN 201811612545 A CN201811612545 A CN 201811612545A CN 109709316 A CN109709316 A CN 109709316A
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Abstract
The present invention is a kind of more target item miniflow test cards, including the cover board for being located at top, the supporting plate being clipped in the middle and positioned at the bottom plate of bottom；The cover board top left side is equipped with the upper micro- reaction chamber observation area of a row of front and back arrangement；It is equipped with sample application zone in the middle part of the cover board top right side, is equipped with point sample mouth in the middle part of the sample application zone.A kind of preparation method of more target item miniflow test cards, comprises the step of: (1) raw material plate of the cover board, the bottom plate and the supporting plate, being on demand cut into defined specification size；(2), supporting plate described in the cover board and the bottom plate is made using the particular manufacturing craft of the cover board, the bottom plate and the supporting plate in raw material plate.A kind of more target item miniflow test cards and preparation method of the present invention, a kind of more target item miniflow test cards can realize more targetings, and the production technology cost of micro-fluidic test card is low, and step is uncomplicated, and process is few.
Description
Technical field
The present invention relates to miniflow test card field more particularly to a kind of more target item miniflow test cards and preparation method.
Background technique
Miniflow testing piece is a kind of to interact integrated micro-total analysis system (Miniaturized total analysis
Systems or Micro total analysis Systems, μ TAS), mainly to Micropump, micro-valve, micro- liquid storage device and micro- detection
The components such as element are attached with microchannel, realize that analysis experiment is integrated in micron-sized space, sampling, are diluted, anti-
It answers, separate and detects etc. and analyzed and executed in the environment of micro-system.Its purpose is that analysis is tested to the maximum extent
The function of room is transferred in portable analytical equipment, is even integrated on the chip of heart size, due to this feature, also by
Referred to as " chip lab ".
2004 U.S. Nian9Yue Business20 magazines have the beauty of " changing following one of the seven kinds of technologies " to chip lab
Reputation.Microfluidic chip technology is nowadays to study most extensively, and one of highest field of liveness, it has been embodied a concentrated reflection of will be huge
Lab analysis system narrows down on micron-sized chip, and this thought has become the important research side of present analysis Instrument Development
To.
The concept of micro-total analysis system is put forward for the first time in nineteen ninety by the Manz and widmer of Ciba-eigy company, Switzerland,
And in two years, realizing Capillary Electrophoresis and Flow Injection Analysis on plate microchip, so that it is determined that micro-system
General thickness is no more than 5 millimeters on plate microchip, and area is several square centimeters to more than ten square centimeters.By 1994, the U.S.
Oak Ridge National Laboratory Ramsey etc. improves the sample injection method of chip capillary cataphoresis, improves micro-fluidic chip
Practical performance.Nineteen ninety-five, using first the micro-fluidic chip enterprise of biochip as representative for studying microarray
CaliperTechnologies company sets up in beauty, and this represent microbe chips to have entered the commodity development stage.With more necks
The development of domain science and technology, microfluidic chip technology have also obtained a large amount of popularization, the research and development of Related product also by
Step starts.After 1998, some micro-fluidic chip enterprises and analysis instrument manufacturer cooperate, and start to produce micro-fluidic point
Analyzer device.In the μ TAS meeting of the 21 century first world, the meeting paper in relation to micro-fluidic chip has accounted for the 87% of sum.With
Microchip research is goed deep into, the material of facture of microchip has also developed to glass and high molecular polymerization from glass matrix
Material is laid equal stress on, and especially in terms of the industrialization of chip, macromolecule polymeric material is more advantageous because being easily achieved batch production.
Although research of the China in terms of microfluidic analysis is more later than external, by the effort of many years, great development is had been achieved with.
2001 in order to accelerate study μ TAS paces, specially held discuss μ TAS development 165 Xiangshan Science seminars.
After 2002, national μ TAS symposium is also held in succession, and the research achievement of μ TAS is in chromatography, capillary electricity
The related fieldss such as swimming, biochip, micro Process, micro-system have gradually been made significant headway.Nowadays, China is to very μ
TAS has very deep innovative development research.The fast development of micro-fluidic chip plays China's life science huge
Impetus.
There is the shortcomings that can not realizing more targetings, and the production technology of micro-fluidic test card in existing micro-fluidic test card
At high cost, step is complicated, and process is more.
For this purpose, designing a kind of more target item miniflow test cards and preparation method, problem above is solved.
Summary of the invention
The present invention is to overcome the above deficiency, provides a kind of more target item miniflow test cards and preparation method.
A kind of more target item miniflow test cards, including the cover board for being located at top, the supporting plate being clipped in the middle and positioned at the bottom of bottom
Plate；
The cover board top left side is equipped with the upper micro- reaction chamber observation area of a row of front and back arrangement；In the cover board top right side
Portion is equipped with sample application zone, is equipped with point sample mouth in the middle part of the sample application zone；
The supporting plate top left side is equipped with the micro- reaction chamber of a row of front and back arrangement, is equipped with sample in the middle part of the supporting plate top right side
Product pond, the sample cell middle part are equipped at remittance sample；
The bottom plate top left side is equipped with micro- reaction chamber under a row of front and back arrangement and carries area；
Micro- reaction chamber carries setting for area under being gone up described in micro- reaction chamber described in micro- reaction chamber observation area, a row and a row described in one row
Seated position corresponds；
The setting position of sample cell described in the sample application zone is corresponding, and accompanies between the sample application zone and the sample cell
Filter device, the filter device by multiple filtration modules at；Position at the point sample mouth remittance sample is corresponding；
Be respectively connected with a point of microchannel on the right side of each micro- reaction chamber, it is described divide microchannel converge be connected with it is total micro-
Pipeline, total microchannel are connected to sample cell.
Further, the material of the supporting plate is papery, the material of the cover board and the bottom plate be PET, PVC, PE, PS or
One of PP.
A kind of preparation method of more target item miniflow test cards, comprises the step of:
(1), the raw material plate of the cover board, the bottom plate and the supporting plate is cut into defined specification size on demand；
(2), the cover board and institute is made using the particular manufacturing craft of the cover board, the bottom plate and the supporting plate in raw material plate
State supporting plate described in bottom plate；The special grinding apparatus can sketch the contours of the microchannel, sample application zone, the sample cell, described micro-
Reaction chamber observation area, micro- reaction chamber and it is described under micro- reaction chamber carry area；
(3), by the cover plate lid in the top of the supporting plate, filtering is clipped between the sample application zone and the sample cell
Device bonds the top of the cover board bottom and the supporting plate；
(4), the supporting plate is placed at the top of the bottom plate, bonds the bottom at the top of the supporting plate with the supporting plate；
(5), supporting plate described in the cover board bonded and the bottom plate is compacted.
The microchannel, the sample-adding are avoided in the bonding part of the step (3) and the step (4) bonding described above
Area, the sample cell, upper micro- reaction chamber observation area, micro- reaction chamber and it is described under micro- reaction chamber carry area；In sample cell
It is mounted with dry chemistry reagent coating.
Further, the material of the supporting plate is papery, the material of the cover board and the bottom plate be PET, PVC, PE, PS or
One of PP.
Further, a kind of more target item miniflow test cards are rectangle, and size is to be respectively as follows: length: 20~30mm, preferably
25mm；Width: 15~45cm, preferably 30mm；Thickness: 0.5~2mm, preferably 0.8mm.
Further, the sample cell size are as follows: raised outer diameter: 10~20mm, preferably 15mm；Depth: 1~5mm, preferably
2mm；0.5~2mm of wall thickness, preferably 1mm；The gradient 5%~30%, preferably 20%；Invaginate diameter: 2~8mm, preferably 5mm；
Further, the microchannel size are as follows: internal diameter: 0.1~1mm, preferably 0.3mm；Length: 1mm~8mm, preferably
5mm；
Further, micro- reaction chamber size are as follows: internal diameter: 1~5mm, preferably 2mm；Depth: 0.05~1.5mm, preferably
0.5mm；Small pitch of holes: 0.01~5mm, preferably 1mm.
Further, a kind of more target item miniflow test cards can be applied in biochemical measurement field, including blood, urine
The measurement such as liver function of a variety of biochemical index of the humoral samples such as liquid, cerebrospinal fluid, leukorrhea and body diffusate, renal function,
The measurement of the indexs of correlation such as blood lipid.
Further, dry chemistry reagent coating is dense by lactic acid coatings of reagent, concentration of hydrogen peroxide coatings of reagent, leukocyte esterase
Spend coatings of reagent, neuraminidase activity coatings of reagent, amine experiment reagent coating, proline base peptidase substrates coatings of reagent, oxygen
Change enzymatic reagent coating, N- acetamido hexosidase substrate reagent coating, in trichomonad specific for hydrolysis protease substrate coatings of reagent
Any three or more mentioned reagent coatings combines form.
The beneficial effects of the present invention are:
A kind of more target item miniflow test cards and preparation method of the present invention, a kind of easy to use, more target item miniflows surveys
More targetings can be achieved in examination card, and the production technology cost of micro-fluidic test card is low, and step is uncomplicated, and process is few.
Detailed description of the invention
Fig. 1 is the configuration schematic diagram of a kind of more target item miniflow test cards and preparation method of the present invention；
Wherein: 1- cover board；3- filter device；4- microchannel；6- bottom plate；7- supporting plate；The sample application zone 21-；22- point sample mouth；23-
Sample cell；24- converges at sample；41- divides microchannel；The total microchannel of 42-；The upper micro- reaction chamber observation area 51-；The micro- reaction chamber of 52-；53-
Under micro- reaction chamber carry area.
Specific embodiment
It is described in detail below with reference to the embodiment of the present invention referring to attached drawing.
The present invention relates to a kind of more target item miniflow test cards and preparation methods.
A kind of more target item miniflow test cards, including the cover board 1 for being located at top, the supporting plate 7 being clipped in the middle and positioned at bottom
Bottom plate 6；
1 top left side of cover board is equipped with the upper micro- reaction chamber observation area 51 of a row of front and back arrangement；1 top right of cover board
Middle side part is equipped with sample application zone 21, is equipped with point sample mouth 22 in the middle part of the sample application zone 21；
7 top left side of supporting plate is equipped with the micro- reaction chamber 52 of a row of front and back arrangement, sets in the middle part of 7 top right side of supporting plate
There is sample cell 23, is equipped in the middle part of the sample cell 23 24 at remittance sample；
6 top left side of bottom plate is equipped with micro- reaction chamber under a row of front and back arrangement and carries area 53；
Micro- reaction chamber carries area under being gone up described in micro- reaction chamber 52 described in micro- reaction chamber observation area 51, a row and a row described in one row
53 setting position corresponds；
The setting position of sample cell 23 described in the sample application zone 21 is corresponding, and the sample application zone 21 and the sample cell 23
Between accompany filter device 3, the filter device 3 by multiple filtration modules at；24 position at the remittance sample of point sample mouth 22
Set correspondence；
The right side of each micro- reaction chamber 52 is respectively connected with point of microchannel 41, described that microchannel 41 is divided to converge connection
There is total microchannel 42, total microchannel 42 is connected to sample cell 23；Dry chemistry reagent coating is mounted in sample cell 23.
Further, the material of the supporting plate 7 is papery, the material of the cover board 1 and the bottom plate 6 is PET, PVC, PE,
One of PS or PP.
Further, the material of the supporting plate 7 is papery, the material of the cover board 1 and the bottom plate 6 is PET, PVC, PE,
One of PS or PP.
Further, a kind of more target item miniflow test cards are rectangle, and size is to be respectively as follows: length: 20~30mm, preferably
25mm；Width: 15~45cm, preferably 30mm；Thickness: 0.5~2mm, preferably 0.8mm.
Further, 23 size of sample cell are as follows: raised outer diameter: 10~20mm, preferably 15mm；Depth: 1~5mm, it is excellent
Select 2mm；0.5~2mm of wall thickness, preferably 1mm；The gradient 5%~30%, preferably 20%；Invaginate diameter: 2~8mm, preferably 5mm；
Further, 4 size of microchannel are as follows: internal diameter: 0.1~1mm, preferably 0.3mm；Length: 1mm~8mm, preferably
5mm；
Further, 23 size of micro- reaction chamber are as follows: internal diameter: 1~5mm, preferably 2mm；Depth: 0.05~1.5mm, preferably
0.5mm；Small pitch of holes: 0.01~5mm, preferably 1mm.
Further, dry chemistry reagent coating is dense by lactic acid coatings of reagent, concentration of hydrogen peroxide coatings of reagent, leukocyte esterase
Spend coatings of reagent, neuraminidase activity coatings of reagent, amine experiment reagent coating, proline base peptidase substrates coatings of reagent, oxygen
Change enzymatic reagent coating, N- acetamido hexosidase substrate reagent coating, in trichomonad specific for hydrolysis protease substrate coatings of reagent
Any three or more mentioned reagent coatings combines form.
Further, a kind of more target item miniflow test cards can be applicable to biochemical measurement field, including blood, urine
Liquid, cerebrospinal fluid, leukorrhea and body diffusate liquid sample a variety of biochemical index measurement such as liver function, renal function, blood
The measurement of rouge index of correlation.
A kind of preparation method of more target item miniflow test cards, comprises the step of:
(1), on demand by the raw material plate of the cover board 1, the bottom plate 6 and the supporting plate 7 be cut into as defined in specification it is big
It is small；
(2), the cover board 1 is made using the particular manufacturing craft of the cover board 1, the bottom plate 6 and the supporting plate 7 in raw material plate
With supporting plate 7 described in the bottom plate 6；The special grinding apparatus can sketch the contours of the microchannel 4, the sample application zone 21, the sample cell
23, upper micro- reaction chamber observation area 51, micro- reaction chamber 52 and it is described under micro- reaction chamber carry area 53；
(3), the cover board 1 is covered into the top in the supporting plate 7, is pressed from both sides between the sample application zone 21 and the sample cell 23
Good filter device 3 bonds the top of cover board 1 bottom and the supporting plate 7；
(4), the supporting plate 7 is placed in 6 top of bottom plate, bonds the bottom at supporting plate 7 top and the supporting plate 7；
(5), supporting plate 7 described in the cover board 1 bonded and the bottom plate 6 is compacted.
The bonding part of the step (3) and the step (4) bonding described above avoid the microchannel 4, it is described plus
Sample area 21, the sample cell 23, upper micro- reaction chamber observation area 51, micro- reaction chamber 52 and it is described under micro- reaction chamber carry
Area 53；
Application method:
Operating procedure using the multinomial joint-detection of more target item miniflow test card row gynecological diseases of the invention is as follows:
Secretion is removed from posterior fornix with aseptic cotton carrier；
The diluted secretion of 300~500ul is added, secretion is allowed to be dissolved into dilution；
Dilute sample 50ul is drawn to be added in sample cell；
By miniflow test card be stored at room temperature 10-20 minutes or 37 DEG C of insulating boxs in stand after ten minutes can be inserted into biochemistry
The automatic colorimetric of detector reads quantitative data, print result；
After miniflow test card detection of the present invention, bio-chemical detector interpretation result
According to the quantitative detection of lactic acid, hydrogen peroxide (H2O2) and leukocyte esterase as a result, judging the theoretical cleaning of vagina
Degree calculates grade (DOC)
According to each testing coating quantitative detection as a result, there is the amine test positive, the Prolyl iminopeptidase positive, neuraminidase
The positive is diagnosable BV.According to each testing coating quantitative detection as a result, there is the N- acetylaminohexose zymolyte test positive to show
The presence of Candida albicans.According to each testing coating quantitative detection as a result, there is trichomonad specific for hydrolysis protease substrate test sun
Property shows the presence of trichomonad.According to each testing coating quantitative detection as a result, having Prolyl iminopeptidase and oxidizing ferment positive simultaneously
Show the presence of gonococcus.
This practical more target item miniflow test card of dry type biochemistry can measure lactic acid, concentration of hydrogen peroxide, white thin simultaneously
Born of the same parents' esterase concentration, neuraminidase activity, amine test, Prolyl iminopeptidase activity, oxidase active, N- acetylaminohexose
Enzymatic activity, trichomonad specific for hydrolysis proteinase activity can accurately react bacterial vaginosis BV in women's leukorrhea secretion, white
Color candida albicans, trichomonad, gonococcus and genital tract microbial environment, the extent of damage of vaginal environment and the cleaning of leukorrhea secretion
Degree is completed so that leucorrhea disease treatment detection is comprehensively primary, easy to operate, quick.Can be more convenient if cooperation dry chemical instrument is read,
Fast, accurately.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of more target item miniflow test cards, which is characterized in that including the cover board for being located at top, the supporting plate being clipped in the middle and be located at
The bottom plate of bottom；
The cover board top left side is equipped with the upper micro- reaction chamber observation area of a row of front and back arrangement；It is set in the middle part of the cover board top right side
There is sample application zone, is equipped with point sample mouth in the middle part of the sample application zone；
The supporting plate top left side is equipped with the micro- reaction chamber of a row of front and back arrangement, is equipped with sample in the middle part of the supporting plate top right side
Pond, the sample cell middle part are equipped at remittance sample；
The bottom plate top left side is equipped with micro- reaction chamber under a row of front and back arrangement and carries area；
Micro- reaction chamber carries the setting position in area under being gone up described in micro- reaction chamber described in micro- reaction chamber observation area, a row and a row described in one row
Set one-to-one correspondence；
The setting position of sample cell described in the sample application zone is corresponding, and filtering is accompanied between the sample application zone and the sample cell
Device, the filter device by multiple filtration modules at；Position at the point sample mouth remittance sample is corresponding；
It is respectively connected with a point of microchannel on the right side of each micro- reaction chamber, it is described to divide microchannel to converge to be connected with total micro-pipe
Road, total microchannel are connected to sample cell.
2. a kind of more target item miniflow test cards according to claim 1, which is characterized in that the material of the supporting plate is paper
The material of matter, the cover board and the bottom plate is one of PET, PVC, PE, PS or PP.
3. a kind of more target item miniflow test cards according to claim 2, which is characterized in that the material of the supporting plate is paper
The material of matter, the cover board and the bottom plate is one of PET, PVC, PE, PS or PP.
4. a kind of more target item miniflow test cards according to claim 3, which is characterized in that a kind of more target item miniflow test cards
For rectangle, size is to be respectively as follows: length: 20~30mm, preferably 25mm；Width: 15~45cm, preferably 30mm；Thickness: 0.5
~2mm, preferably 0.8mm.
5. a kind of more target item miniflow test cards according to claim 4, which is characterized in that the sample cell size are as follows:
Raised outer diameter: 10~20mm, preferably 15mm；Depth: 1~5mm, preferably 2mm；0.5~2mm of wall thickness, preferably 1mm；The gradient 5%~
30%, preferably 20%；Invaginate diameter: 2~8mm, preferably 5mm.
6. a kind of more target item miniflow test cards according to claim 5, which is characterized in that the microchannel size are as follows: interior
Diameter: 0.1~1mm, preferably 0.3mm；Length: 1mm~8mm, preferably 5mm.
7. a kind of more target item miniflow test cards according to claim 6, which is characterized in that micro- reaction chamber size are as follows:
Internal diameter: 1~5mm, preferably 2mm；Depth: 0.05~1.5mm, preferably 0.5mm；Small pitch of holes: 0.01~5mm, preferably 1mm.
8. a kind of more target item miniflow test cards according to claim 7, which is characterized in that can apply in biochemical measurement
Field, including a variety of biochemical index of the humoral samples such as blood, urine, cerebrospinal fluid, leukorrhea and body diffusate
Measurement such as liver function, renal function, the measurement of the indexs of correlation such as blood lipid.
9. a kind of more target item miniflow test cards according to claim 8, which is characterized in that dry chemistry reagent coating is by lactic acid
Coatings of reagent, concentration of hydrogen peroxide coatings of reagent, leukocyte esterase Concentration Reagent coating, neuraminidase activity coatings of reagent,
Amine experiment reagent coating, proline base peptidase substrates coatings of reagent, oxidase reagent coating, the examination of N- acetamido hexose zymolyte
Any three or more mentioned reagent coatings combines in agent coating, trichomonad specific for hydrolysis protease substrate coatings of reagent form.
10. a kind of preparation method of more target item miniflow test cards, which is characterized in that comprise the step of:
(1), the raw material plate of the cover board, the bottom plate and the supporting plate is cut into defined specification size on demand；
(2), the cover board and the bottom is made using the particular manufacturing craft of the cover board, the bottom plate and the supporting plate in raw material plate
Supporting plate described in plate；The special grinding apparatus can sketch the contours of the microchannel, the sample application zone, the sample cell, upper micro- reaction
Room observation area, micro- reaction chamber and it is described under micro- reaction chamber carry area；
(3), by the cover plate lid in the top of the supporting plate, filtering dress is clipped between the sample application zone and the sample cell
It sets, bonds the top of the cover board bottom and the supporting plate；
(4), the supporting plate is placed at the top of the bottom plate, bonds the bottom at the top of the supporting plate with the supporting plate；
(5), supporting plate described in the cover board bonded and the bottom plate is compacted；
The bonding part of the step (3) and the step (4) bonding described above avoid the microchannel, the sample application zone,
The sample cell, upper micro- reaction chamber observation area, micro- reaction chamber and it is described under micro- reaction chamber carry area；Sample cell is built-in
It is loaded with dry chemistry reagent coating.
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Application publication date: 20190503 |