CN109694558A - Nano anti-biotic material and its application with bionic function - Google Patents

Nano anti-biotic material and its application with bionic function Download PDF

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Publication number
CN109694558A
CN109694558A CN201711001006.0A CN201711001006A CN109694558A CN 109694558 A CN109694558 A CN 109694558A CN 201711001006 A CN201711001006 A CN 201711001006A CN 109694558 A CN109694558 A CN 109694558A
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CN
China
Prior art keywords
parts
bionic function
nano anti
biotic material
antibacterial
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711001006.0A
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Chinese (zh)
Inventor
李鹤成
俞磊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Jingyu Biomedical Technology Co ltd
Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd
Original Assignee
Shanghai Jingyu Biomedical Technology Co ltd
Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd
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Application filed by Shanghai Jingyu Biomedical Technology Co ltd, Ruinjin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Co Ltd filed Critical Shanghai Jingyu Biomedical Technology Co ltd
Priority to CN201711001006.0A priority Critical patent/CN109694558A/en
Publication of CN109694558A publication Critical patent/CN109694558A/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/105—Polyesters not covered by A61L17/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2296—Oxides; Hydroxides of metals of zinc
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/24—Acids; Salts thereof
    • C08K3/26—Carbonates; Bicarbonates
    • C08K2003/265—Calcium, strontium or barium carbonate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C08K2003/321—Phosphates
    • C08K2003/328—Phosphates of heavy metals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

Abstract

The nano antiseptic plastic master batch and its application that the invention discloses a kind of with bionic function, the plastic master batch is made of following parts by weight of component: 1 ~ 10 part of lubricant, 1 ~ 30 part of antibacterial agent, 80 ~ 100 parts of polycaprolactone resin, 1 ~ 10 part of sodium carboxymethylcellulose, 1 ~ 10 part of calcium carbonate, 1 ~ 30 part of starch, 1 ~ 10 part of chitosan, 1 ~ 10 part of fibroin albumen.The polycaprolactone resin that the master batch selects biocompatibility high is basis material, reduces human body repellency；The addition of antibacterial agent can reduce the incidence of postoperative wound infection, promote the healing of wound.Mother particles of antibacterial plastics disclosed by the invention for operation suture thread has many advantages, such as simple production process, and processability is good and can continuous large-scale production.

Description

Nano anti-biotic material and its application with bionic function
Technical field
The present invention relates to a kind of technical field of polymer composite materials, and in particular to a kind of nanometer with bionic function is anti- Bacterium material and its application.
Background technique
Operation suture thread refer in surgical operation or wound disposition in, be used for hemostasis by ligation, Suture hemostasis And the Special Linear material of tissue suture.There are many type of operation suture thread, can be divided by material type natural, synthesis With metal suture line.Since synthesis suture has the characteristics that intensity is big, tissue reaction is small, easy disinfection, suture is become Center.Developing new synthetic fibers suture and being modified to existing suture is the emphasis studied from now on.
Antibiotic plastic be it is a kind of in use environment itself to stain on plastics bacterium, mould, alcohol mother bacterium, algae very The plastics that inhibition or killing effect have been waited to virus keep itself clean by inhibiting the breeding of microorganism.Currently, antibacterial is moulded Material is mainly obtained by the method for adding a small amount of antibacterial agent in common plastics.
Currently, surgical operation postoperative infection and its caused complication clinically still occupy biggish ratio, to trouble The rehabilitation of person especially gerontal patient brings unfavorable factor.Therefore, it is badly in need of developing a kind of be made of antibiotic plastic while can be with Reduce the antibacterial operation suture of postoperative infection.Antibiotic plastic is applied to the development of operation suture thread, will further widen plastics In the application range of medical field.
Summary of the invention
In order to overcome the deficiencies of the prior art, present invention aims at: a kind of nano-antibacterial material with bionic function is provided Material.
A further object of the present invention is to provide the applications of the above-mentioned nano anti-biotic material product with bionic function.This hair It is bright to adopt the following technical scheme that
A kind of nano anti-biotic material with bionic function, the master batch are made of following parts by weight of component: 1 ~ 10 part of lubricant, being resisted 1 ~ 30 part of microbial inoculum, 80 ~ 100 parts of polycaprolactone resin, 1 ~ 10 part of sodium carboxymethylcellulose, 1 ~ 10 part of calcium carbonate, 1 ~ 30 part of starch, 1 ~ 10 part of chitosan, 1 ~ 10 part of fibroin albumen.
The lubricant is glycerol.
The antibacterial agent is the inorganic antiseptic of argentiferous, zinc, copper one or more of them metallic element.
The polycaprolactone resin as matrix resin, 50 DEG C of vacuum drying treatments for 24 hours.
The present invention provides the application that the above-mentioned nano anti-biotic material with bionic function of one kind is used to prepare operation suture thread.
The polycaprolactone resin that the present invention selects biocompatibility high is basis material, reduces human body repellency；Antibacterial agent Addition can reduce the incidence of postoperative wound infection, promote the healing of wound.It is disclosed by the invention for operation suture thread Mother particles of antibacterial plastics has many advantages, such as simple production process, and processability is good and can continuous large-scale production.
The beneficial effects of the present invention are:
1. the present invention polycaprolactone high for the mother particles of antibacterial plastics selection biocompatibility of operation suture thread is as matrix tree Rouge, reduces the rejection of human body, and the addition of antibacterial agent can reduce the incidence of postoperative wound infection, promote the healing of wound.
2. antibiotic plastic of the present invention has widened plastics in the application range of medical field for operation suture thread.
3. the present invention has simple production process for the mother particles of antibacterial plastics of operation suture thread, non-environmental-pollution, can connect The features such as continuous property scale industrial production.
Specific embodiment
The present invention is described in detail below by specific example, but protection scope of the present invention is not only restricted to these Examples of implementation.
Embodiment 1:
A kind of nano anti-biotic material with bionic function, is made of following parts by weight of component: 5 parts of glycerol, carboxymethyl cellulose 15 parts of copper complex, 90 parts of polycaprolactone resin, 2 parts of sodium carboxymethylcellulose, 5 parts of calcium carbonate, 5 parts of starch, 2 parts of chitosan, 3 parts of fibroin albumen, by carboxymethyl cellulose copper complex, polycaprolactone resin, sodium carboxymethylcellulose, calcium carbonate, starch, shell Glycan, fibroin albumen are mixed into after uniform powder and are uniformly mixed again with glycerol, and double screw extruder is added from main spout, into Row squeezes out processing, and the main processing temperature of double screw extruder is 125 DEG C, engine speed 200 rpm, main 15 rpm of feeding revolving speed, Pelletizing, low temperature drying, the antibacterial matrices after drying are carried out again high-temperature fusion spinning, twisting, sterilizing and etc. can be obtained Operation suture thread.It takes mother particles of antibacterial plastics made from the present embodiment to be molded into plastics template, tests the antibiotic property of the plastics template Can, as a result as shown in the table.
Embodiment 2:
A kind of nano anti-biotic material with bionic function, is made of following parts by weight of component: 8 parts of glycerol, silver-loaded zirconium phosphate 10 Part, 80 parts of polycaprolactone resin, 5 parts of sodium carboxymethylcellulose, 3 parts of calcium carbonate, 15 parts of starch, 7 parts of chitosan, fibroin albumen 8 Part, silver-loaded zirconium phosphate, polycaprolactone resin, sodium carboxymethylcellulose, calcium carbonate, starch, chitosan, fibroin albumen are mixed into It is uniformly mixed again after uniform powder with glycerol, double screw extruder is added from main spout, carry out extrusion processing, twin-screw squeezes It is 130 DEG C, engine speed 210 rpm, main 18 rpm of feeding revolving speed that owner, which wants processing temperature, out, and pelletizing, low temperature drying will be dried Antibacterial matrices afterwards carry out again high-temperature fusion spinning, twisting, sterilizing and etc. operation suture thread can be obtained.Take the present embodiment Mother particles of antibacterial plastics obtained is molded into plastics template, tests the anti-microbial property of the plastics template, as a result as shown in the table.
Embodiment 3:
A kind of nano anti-biotic material with bionic function, is made of following parts by weight of component: 3 parts of glycerol, 25 parts of zinc oxide, gathering It 95 parts of caprolactone resin, 8 parts of sodium carboxymethylcellulose, 9 parts of calcium carbonate, 25 parts of starch, 9 parts of chitosan, 6 parts of fibroin albumen, will Zinc oxide, polycaprolactone resin, sodium carboxymethylcellulose, calcium carbonate, starch, chitosan, fibroin albumen are mixed into uniform powder It is uniformly mixed again with glycerol afterwards, double screw extruder is added from main spout, carries out extrusion processing, double screw extruder is main Processing temperature is 120 DEG C, engine speed 180 rpm, main 13 rpm of feeding revolving speed, pelletizing, low temperature drying, by the antibacterial after drying Master batch carry out again high-temperature fusion spinning, twisting, sterilizing and etc. operation suture thread can be obtained.It takes and resists made from the present embodiment Bacterium plastic master batch is molded into plastics template, tests the anti-microbial property of the plastics template, as a result as shown in the table.
The mother particles of antibacterial plastics of embodiment 1-3 preparation examines the anti-microbial property of Escherichia coli according to QB/T 2591-2003 Survey method is detected with standard.
。

Claims (5)

1. a kind of nano anti-biotic material with bionic function, the material are made of following parts by weight of component: 1 ~ 10 part of lubricant, 1 ~ 30 part of antibacterial agent, 80 ~ 100 parts of polycaprolactone resin, 1 ~ 10 part of sodium carboxymethylcellulose, 1 ~ 10 part of calcium carbonate, starch 1 ~ 30 Part, 1 ~ 10 part of chitosan, 1 ~ 10 part of fibroin albumen.
2. according to claim 1 with the nano anti-biotic material of bionic function, it is characterised in that: the lubricant is sweet Oil.
3. according to claim 1 with bionic function nano anti-biotic material, it is characterised in that: the antibacterial agent be containing Silver, zinc, copper one or more of them metallic element inorganic antiseptic.
4. according to claim 1 with the nano anti-biotic material of bionic function, it is characterised in that: the polycaprolactone resin 50 DEG C of vacuum drying treatments for 24 hours.
5. -4 any nano anti-biotic materials with bionic function are used to prepare answering for operation suture thread according to claim 1 With.
CN201711001006.0A 2017-10-24 2017-10-24 Nano anti-biotic material and its application with bionic function Pending CN109694558A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711001006.0A CN109694558A (en) 2017-10-24 2017-10-24 Nano anti-biotic material and its application with bionic function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711001006.0A CN109694558A (en) 2017-10-24 2017-10-24 Nano anti-biotic material and its application with bionic function

Publications (1)

Publication Number Publication Date
CN109694558A true CN109694558A (en) 2019-04-30

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Country Status (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110354298A (en) * 2019-07-26 2019-10-22 南京聚屹新材料有限公司 It is a kind of to be cross-linked in situ silver nanowires/polycaprolactone operation suture thread preparation method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110354298A (en) * 2019-07-26 2019-10-22 南京聚屹新材料有限公司 It is a kind of to be cross-linked in situ silver nanowires/polycaprolactone operation suture thread preparation method
CN110354298B (en) * 2019-07-26 2021-08-17 南京聚屹新材料有限公司 Preparation method of in-situ crosslinked silver nanowire/polycaprolactone surgical suture

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Application publication date: 20190430