CN109678806A - A kind of monomethylation synthetic method of efficient aromatic primary amine - Google Patents
A kind of monomethylation synthetic method of efficient aromatic primary amine Download PDFInfo
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- CN109678806A CN109678806A CN201811582412.5A CN201811582412A CN109678806A CN 109678806 A CN109678806 A CN 109678806A CN 201811582412 A CN201811582412 A CN 201811582412A CN 109678806 A CN109678806 A CN 109678806A
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- primary amine
- aromatic primary
- monomethylation
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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Abstract
The present invention relates to organic synthesis field more particularly to a kind of synthetic methods of the monomethylation of efficient aromatic primary amine, include the following steps: using aromatic primary amine as raw material, corresponding hexahydro -1,3,5- triaryl -1 are obtained with formaldehyde or polyformaldehyde reaction, 3,5- triaizine compounds；The monomethylation product of aromatic primary amine is obtained with catalytic hydrogenation under the action of Pd/C catalyst again.The feature of invention maximum be it is easy to operate, mild condition, raw material is cheap and easily-available, can obtain in high yield, the monomethylation product of highly selective aromatic primary amine.Post-processing is simple, improves production efficiency, can be easily achieved industrial mass production, and not will cause equipment corrosion and environmental pollution.
Description
Technical field
The present invention relates to organic synthesis field more particularly to a kind of monomethylation synthetic methods of efficient aromatic primary amine.
Background technique
The monomethylation method of aromatic primary amine is widely used in organic synthesis field, but has seldom method to can be fragrance
The methylation reaction of primary amine rests on the monomethyl stage, so finding a kind of monomethylation method of suitable aromatic primary amine especially
It is important.
The Chinese invention patent of Publication No. CN103172523A discloses a kind of method of selective N-methylation primary amine,
It specifically discloses and is reacted in the presence of metal iridium or ruthenium complex and alkali by primary amine derivatives (Formula II) with methanol (formula III)
N- methylation primary amine, this method yield with higher are obtained, but the purifying of its product need to be chromatographed by column, can not be suitable for work
Industry metaplasia produces.
The Chinese invention patent of Publication No. CN107056681A discloses a kind of support method for cloth midbody compound 1- benzyl
The preparation method of base -3- methylamino -4- methyl piperidine dihydrochloride, 0084-0086 sections of specification disclose the system of chemical compounds I
Primary amino-compound is reacted with methylating reagent, alkali, then obtains monomethylation primary amine with sodium borohydride reduction by Preparation Method；This is anti-
Answer overall yield lower, and its monomethylation that can only be served only for fat primary amine.
Summary of the invention
The technical problem to be solved by the present invention is providing one kind.
In the first aspect of the present invention, a kind of synthetic method of the monomethylation of efficient aromatic primary amine is provided, including
Following steps:
(1) aromatic primary amine shown in formula (I) is raw material, obtains corresponding hexahydro -1,3 with formaldehyde or polyformaldehyde reaction,
5- Trisaryl-1,3,5-triazine compound (II)；
(2) formula (II) compound represented obtains the monomethyl of aromatic primary amine with catalytic hydrogenation under the action of Pd/C catalyst
Change product (III)；
Preferably, the R group is selected from H, halogen, C1~6Alkyl, C1~6Alkoxy replaces C1~6Alkyl；The substitution
C1~6Alkyl refers to the C at least replaced by a halogen1~6Alkyl；Further, the R group is selected from H, halogen, C1~4Alkyl,
C1~4Alkoxy replaces C1~4Alkyl；The substitution C1~4Alkyl refers to the C at least replaced by a halogen1~4Alkyl.
Preferably, the halogen is selected from fluorine, chlorine, bromine or iodine.
Preferably, the R group is ortho position, meta or para position substitution.
Preferably, catalyst of triethylamine is also added into the step (1)；The aromatic primary amine, formaldehyde/paraformaldehyde and
The molar ratio range of triethylamine is 1:0.2~2:0.01~0.5；Further, the aromatic primary amine, formaldehyde/paraformaldehyde and
The molar ratio range of triethylamine is 1:1~2:0.1~0.5；When reaction raw materials are paraformaldehyde, with the formaldehyde in paraformaldehyde
Unit mole is as paraformaldehyde mole.
Preferably, solvent used in the step (1) is selected from toluene, methylene chloride or other non-polar organic solvents.
Preferably, hexahydro -1,3 in the step (2), 5- triaryl -1,3,5-triazines compound (II) and Pd/C matter
Amount is 1:0.01~0.1 than range；Further, hexahydro -1,3 in the step (2), 5- triaryl -1,3,5-triazines chemical combination
The quality of object (II) and Pd/C are 1:0.015~0.043 than range.
Preferably, Hydrogen Vapor Pressure is 1.0~10.0Mpa in the step (2), and reaction temperature is 0~100 DEG C.
Preferably, solvent used in the step (2) is selected from tetrahydrofuran, dioxane, dichloro hexane or two chloroethenes
Alkane；The dichloroethanes is selected from 1,1- dichloroethanes or 1,2- dichloroethanes；Dichloro hexane is selected from 1,6- dichloro hexane.
The Chinese name of compound, which has with structural formula, in the present invention conflicts, and is subject to structural formula.
The synthetic method of the monomethylation of efficient aromatic primary amine provided by the invention is easy to operate, mild condition, raw material
It is cheap and easily-available, the monomethylation product of high yield, highly selective aromatic primary amine can be obtained；And post-processing is simple, improves
Production efficiency can be easily achieved industrial mass production, and not will cause equipment corrosion and environmental pollution.
Specific embodiment
Illustrate the present invention below in conjunction with example, but does not limit the present invention.In the art, technical staff is the present invention
Simple replacement or improvement belong in the technical solution protected of the present invention.
Embodiment 1
(1) synthesis of hexahydro -1,3,5- three-(4-F phenyl) -1,3,5- triazine
22g 4- fluoroaniline (molecular weight 111.1,0.20mol) is added into 250mL four-hole bottle, 6.0g paraformaldehyde (phase
When in 0.20mol formaldehyde), 2.0g triethylamine (mole 101.2,0.02mol), 120g toluene, slowly increase temperature to 60 degree,
Heat preservation 1 hour, then increase temperature reflux and react fully reacting in 3 hours.It is evaporated toluene after reaction up to 24g white solid
Hexahydro -1,3,5- tri--(4-F phenyl) -1,3,5-triazines, yield 96%.
(2) synthesis of N- methyl -4- fluoroaniline
6g hexahydro -1,3,5- tri--(4-F phenyl) -1,3,5-triazines, 0.17g Pd/C (palladium are added into 100mL autoclave
Content is 1%wt), 40mL THF closes reactor, air is displaced with hydrogen, and keep the pressure in the bottle with 60 kg hydrogens,
It is stirred 12 hours under room temperature.Reaction solution, Filtration of catalyst are taken out after reaction, and filtrate removes THF up to product N- first
Base -4- fluoroaniline 5.8g (yield 95%, quantitatively 97%)
Embodiment 2
(1) synthesis of hexahydro -1,3,5- three-(2- aminomethyl phenyl) -1,3,5- triazine
21g 2-aminotoluene (molecular weight 107.2,0.20mol) is added into 250mL four-hole bottle, 12g paraformaldehyde (phase
When in 0.40mol formaldehyde), 10.1g triethylamine (mole 101.2,0.1mol), 120g toluene, slowly increase temperature to 60 degree,
Heat preservation 1 hour, then increase temperature reflux and react fully reacting in 3 hours.It is evaporated toluene after reaction up to 23g white solid
Hexahydro -1,3,5- tri--(2- aminomethyl phenyl) -1,3,5-triazines, yield 98%.
(2) N- methyl -2-aminotoluene synthesis
5.8g hexahydro -1,3,5- tri--(2- aminomethyl phenyl) -1,3,5-triazines, 0.25g are added into 100mL autoclave
Pd/C (palladium content 1%wt), 40mL THF close reactor, displace air with hydrogen, and keep bottle with 60 kg hydrogens
Interior pressure stirs 12 hours under room temperature.Reaction solution, Filtration of catalyst are taken out after reaction, and filtrate removes THF up to producing
Product N- methyl -2-aminotoluene 5.7g (yield 96%, quantitatively 98%)
Embodiment 3
(1) synthesis of hexahydro -1,3,5- three-(3- methoxyphenyl) -1,3,5- triazine
24.5g 3- aminoanisole (molecular weight 123.2,0.20mol) is added into 300mL four-hole bottle, 7.2g poly first
Aldehyde (is equivalent to 0.24mol formaldehyde), 6.1g triethylamine (mole 101.2,0.06mol), 150g methylene chloride, slowly increases temperature
Degree keeps the temperature 1 hour to 60 degree, then increases temperature reflux and react fully reacting in 3 hours.It is evaporated toluene after reaction to obtain the final product
Hexahydro -1,3 of 24.5g faint yellow solid, 5- tri--(3- methoxyphenyl) -1,3,5-triazines, yield 92%.
(2) synthesis of N- methyl -3- aminoanisole
6.6g hexahydro -1,3,5- tri--(3- methoxyphenyl) -1,3,5-triazines, 0.10g are added into 100mL autoclave
Pd/C (palladium content 1%wt), 40mL THF close reactor, displace air with hydrogen, and keep bottle with 60 kg hydrogens
Interior pressure stirs 12 hours under room temperature.Reaction solution, Filtration of catalyst are taken out after reaction, and filtrate removes THF up to producing
Product N- methyl -3- aminoanisole 6.2g (yield 92%, quantitatively 95%).
What has been described above is only a preferred embodiment of the present invention, it is noted that for those of ordinary skill in the art
For, without departing from the concept of the premise of the invention, various modifications and improvements can be made, these belong to the present invention
Protection scope.
Claims (10)
1. a kind of synthetic method of the monomethylation of efficient aromatic primary amine, it is characterised in that include the following steps:
(1) aromatic primary amine shown in formula (I) is raw material, obtains corresponding hexahydro -1,3,5- tri- with formaldehyde or polyformaldehyde reaction
Aryl -1,3,5- triaizine compounds (II)；
(2) monomethylation that formula (II) compound represented catalytic hydrogenation under the action of Pd/C catalyst obtains aromatic primary amine produces
Object (III)；
2. the synthetic method of the monomethylation of efficient aromatic primary amine as described in claim 1, which is characterized in that the R base
Group is selected from H, halogen, C1~6Alkyl, C1~6Alkoxy replaces C1~6Alkyl；The substitution C1~6Alkyl refers at least by a halogen
The C that element replaces1~6Alkyl.
3. the synthetic method of the monomethylation of efficient aromatic primary amine as described in claim 1, which is characterized in that the R base
Group is selected from H, halogen, C1~4Alkyl, C1~4Alkoxy replaces C1~4Alkyl；The substitution C1~4Alkyl refers at least by a halogen
The C that element replaces1~4Alkyl.
4. the synthetic method of the monomethylation of efficient aromatic primary amine as claimed in claim 2, which is characterized in that the halogen
Selected from fluorine, chlorine, bromine or iodine.
5. the synthetic method of the monomethylation of efficient aromatic primary amine as described in claim 1, which is characterized in that the R base
Group is ortho position, meta or para position substitution.
6. the synthetic method of the monomethylation of efficient aromatic primary amine as described in claim 1, which is characterized in that the step
(1) catalyst of triethylamine is also added into；The molar ratio range of the aromatic primary amine, formaldehyde/paraformaldehyde and triethylamine is 1:
0.2~2:0.01~0.5.
7. the synthetic method of the monomethylation of efficient aromatic primary amine as described in claim 1, which is characterized in that the step
(1) solvent used in is selected from toluene, methylene chloride or other non-polar organic solvents.
8. the synthetic method of the monomethylation of efficient aromatic primary amine as described in any one of claims 1 to 7, feature exist
In, hexahydro -1,3 in the step (2), the quality of 5- triaryl -1,3,5-triazines compound (II) and Pd/C are 1 than range:
0.01~0.1.
9. the synthetic method of the monomethylation of efficient aromatic primary amine as described in any one of claims 1 to 7, feature exist
In Hydrogen Vapor Pressure is 1.0~10.0Mpa in the step (2), and reaction temperature is 0~100 DEG C.
10. the synthetic method of the monomethylation of efficient aromatic primary amine as described in any one of claims 1 to 7, feature exist
In solvent used in the step (2) is selected from tetrahydrofuran, dioxane, dichloro hexane or dichloroethanes；Two chloroethene
Alkane is selected from 1,1- dichloroethanes or 1,2- dichloroethanes；Dichloro hexane is 1,6- dichloro hexane.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101265255A (en) * | 2008-04-28 | 2008-09-17 | 四川大学 | Method for preparing benzoxazine intermediate containing triazine structure |
| CN106316866A (en) * | 2015-06-29 | 2017-01-11 | 中国科学院上海应用物理研究所 | Preparation method of N-methylamine compound |
-
2018
- 2018-12-24 CN CN201811582412.5A patent/CN109678806B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101265255A (en) * | 2008-04-28 | 2008-09-17 | 四川大学 | Method for preparing benzoxazine intermediate containing triazine structure |
| CN106316866A (en) * | 2015-06-29 | 2017-01-11 | 中国科学院上海应用物理研究所 | Preparation method of N-methylamine compound |
Non-Patent Citations (2)
| Title |
|---|
| HYUN-JOON HA ET AL.: "Facile Method for the Monomethylation of Anilines", 《SYNTHETIC COMMUNICATIONS》 * |
| MOHAMMED A1 SHAIK ET AL.: "Bequeme Darstellung von reinen N-Methylalkylaminen durch Zink/Salzsaure-Reduktion von 1,3,5-Tris( alkyl)-hexahydro-1,3,5-triazine", 《ARCH.PHARM.》 * |
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