CN109675116A - A kind of preparation method of PEEK composite material joint prosthesis - Google Patents

A kind of preparation method of PEEK composite material joint prosthesis Download PDF

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Publication number
CN109675116A
CN109675116A CN201910155403.6A CN201910155403A CN109675116A CN 109675116 A CN109675116 A CN 109675116A CN 201910155403 A CN201910155403 A CN 201910155403A CN 109675116 A CN109675116 A CN 109675116A
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CN
China
Prior art keywords
peek
joint prosthesis
powder
composite material
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910155403.6A
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Chinese (zh)
Inventor
不公告发明人
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Yongkang Renhe Hardware Products Co Ltd
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Yongkang Renhe Hardware Products Co Ltd
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Priority to CN201910155403.6A priority Critical patent/CN109675116A/en
Publication of CN109675116A publication Critical patent/CN109675116A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Abstract

The present invention relates to a kind of preparation methods of PEEK composite material joint prosthesis, belong to medical material tech field.Abrasion and fibrous fracture can still occur under complicated physiological condition and stress for existing compound artificial joint material, even there is the possibility of fracture, the problem of particle that abrasion generates can also cause the inflammatory reaction of local organization, provides a kind of preparation method of PEEK composite material joint prosthesis.Have many advantages, such as good biocompatibility and wearability using the joint prosthesis that technical solution of the present invention manufactures.

Description

A kind of preparation method of PEEK composite material joint prosthesis
Technical field
The present invention relates to a kind of preparation methods of PEEK composite material joint prosthesis, belong to medical material tech field.
Background technique
Joint prosthesis is borrowed to treat the diseases such as fracture and joint deformity, arthrocleisis and various destructive Bones and joints Implantable prosthese made of artificial material is helped, to replace damaging or occurring the joint of lesion.Artificial joint replacement is to control Advanced stage Osteoarthritis is treated, arthralgia is eliminated and improves the effective ways of function, is praised together with Fracture internal fixaiion operation For the breakthrough of 20th century field of orthopaedics greatness, the joint correction and restore normal function that it keeps these ill help some joints The rheumatoid arthritis and osteoarthritis patient seriously destroyed improves quality of life.
Medical practice shows that artificial joint material performance and its Bio-tribological Properties use quality and clinic for joint Service life plays decisive role.Therefore, researcher has carried out extensive work in this respect.Research thinks, joint prosthesis conduct A kind of implantation organ should generally be met the following requirements: (1) raw to substitute the joint of damage or lesion and restore function Object compatibility is good.(2) biomechanical compatibility is good.(3) bioconjugation performance is good.(4) material being implanted into should also have friction system The characteristics of number low, rub resistance, wear-resistant and good corrosion resistance, the formation rate of wear particle is low, hardly produces in use process Raw wear debris.(5) fatigue behaviour is good.In addition, artificial joint material should also be convenient for clinical manipulation, it is readily synthesized manufacture, is had good Good processability, so as to mass production, quality control and detection are carried out, cheap, easy to spread and application.Mesh Before, the material for manufacture of intraocular joint is mainly composite material, in order to solve between joint prosthesis and bone tissue elasticity modulus not The problem of matching, people are using composite material come manufacture of intraocular joint.Composite material has elasticity modulus closer to nature bone, power Learn performance and biocompatibility more preferably feature, nature bone it is inherently a kind of by collagenous fibres by the composite wood of HA mineralising Material, but under complicated physiological condition and stress abrasion and fibrous fracture can still occur for existing composite material, even There is the possibility of fracture, the particle for wearing generation can also cause the inflammatory reaction of local organization.Therefore composite material is closed as artificial Section still needs to be furtherd investigate.
Summary of the invention
The technical problems to be solved by the invention: for existing compound artificial joint material complicated physiological condition and by Abrasion and fibrous fracture can still occur under power state, or even have the possibility of fracture, the particle for wearing generation can also cause local group The problem of inflammatory reaction knitted, provides a kind of preparation method of PEEK composite material joint prosthesis.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is that:
(1) heat treatment of PEEK powder
By 100 gram particle degree be 150 microns PEEK powder and 5 gram particle degree be 10 microns copper powder, 1 gram of antioxidant 136 and 0.1 gram of white carbon black is placed in chamber type electric resistance furnace after mixing, is heat-treated 3~5 hours under conditions of 280~310 DEG C, from So after cooling, ball mill is utilized to carry out ball milling 20~25 minutes；
(2) pretreatment of CF
Untreated CF is placed in in 100~130 DEG C of vacuum oven 20~24 hours dry, cooling, it is spare；
(3) preparation of PEEK/CF composite powder
Pretreated CF is added in the PEEK powder through Overheating Treatment, 10~15 points of ball milling in ball mill are placed in Uniformly mixed PEEK/CF composite powder is made in clock；
(4) preparation of PEEK compound artificial joint
Artificial joint prosthesis is made in uniformly mixed PEEK/CF composite powder using hot press.Specific molding processing work Skill are as follows: composite powder is put into hot press when being warming up to 200 DEG C and is preheated, is heated to be forced into 6MPa at 250 DEG C, until 280 DEG C When bleed off pressure preheating 1~2 minute, repressurization to 8MPa is heated to 310 DEG C and bleeds off pressure preheating again 1~2 minute, repressurization to 10MPa, Continue to heat up, processing temperature maintains 360 DEG C, pressure 10MPa, and soaking time is 10~12 minutes.
The beneficial effects of the present invention are:
Have many advantages, such as good biocompatibility and wearability using the joint prosthesis that technical solution of the present invention manufactures.
Specific embodiment
Example 1.
According to parts by weight, respectively weigh 100 parts of granularities be 150 microns PEEK powder, 5 parts of granularities be 10 microns copper Powder, 1 part of antioxidant 136 and 0.1 part white carbon black, are placed in chamber type electric resistance furnace, after mixing in 280~310 DEG C of condition Lower heat treatment 3~5 hours after natural cooling, is carried out ball milling 20~25 minutes using ball mill, component A is made；
Untreated CF is placed in in 100~130 DEG C of vacuum oven 20~24 hours dry, cooling, obtained second group Part；
According to parts by weight, 100 parts of component A and 30 parts of component Bs are weighed respectively, are uniformly mixed and are placed on ball in ball mill The third component is made in mill 10~15 minutes；
The third component is put into hot press knee joint mold when hot press is warming up to 200 DEG C and is preheated, is heated to add at 250 DEG C It is depressed into 6MPa, is heated to bleeding off pressure preheating 2 minutes at 280 DEG C, repressurization to 8MPa is heated to 310 DEG C and bleeds off pressure preheating 2 minutes again, Repressurization continues to heat up, processing temperature maintains 360 DEG C, pressure 10MPa, and soaking time is 12 minutes to 10MPa；Die sinking, Take out knee-joint prosthesis.
After measured, the tensile strength of knee-joint prosthesis is about 115MPa, and impact strength is about 45kJ/m2, it is seen then that the present invention The joint prosthesis of preparation has excellent mechanical property.

Claims (1)

1. a kind of preparation method of PEEK composite material joint prosthesis, it is characterised in that specific preparation step are as follows:
(1) by 100 gram particle degree be 150 microns PEEK powder and 5 gram particle degree be 10 microns copper powder, 1 gram of antioxidant 136 and 0.1 gram of white carbon black is placed in chamber type electric resistance furnace after mixing, is heat-treated 3~5 hours under conditions of 280~310 DEG C, from So after cooling, ball mill is utilized to carry out ball milling 20~25 minutes；
(2) untreated CF is placed in in 100~130 DEG C of vacuum oven 20~24 hours dry, cooling, it is spare；
(3) pretreated CF is added in the PEEK powder through Overheating Treatment, is placed in ball milling 10~15 minutes in ball mill, Uniformly mixed PEEK/CF composite powder is made；
(4) composite powder is put into hot press when hot press is warming up to 200 DEG C and is preheated, is heated to be forced into 6MPa at 250 DEG C, Preheating is bled off pressure 1~2 minute when to 280 DEG C, and repressurization to 8MPa is heated to 310 DEG C and bleeds off pressure preheating again 1~2 minute, and repressurization is extremely 10MPa continues to heat up, and processing temperature maintains 360 DEG C, pressure 10MPa, and soaking time is 10~12 minutes.
CN201910155403.6A 2019-02-18 2019-02-18 A kind of preparation method of PEEK composite material joint prosthesis Pending CN109675116A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910155403.6A CN109675116A (en) 2019-02-18 2019-02-18 A kind of preparation method of PEEK composite material joint prosthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910155403.6A CN109675116A (en) 2019-02-18 2019-02-18 A kind of preparation method of PEEK composite material joint prosthesis

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CN109675116A true CN109675116A (en) 2019-04-26

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582860A (en) * 2003-08-20 2005-02-23 中国科学院金属研究所 Carbon fiber inforced poly(ether-ether-ketone) composite bone fracture plate
CN1593356A (en) * 2004-06-24 2005-03-16 上海交通大学 Whole coxa thighbone prosthesis and method for making same
CN103479443A (en) * 2013-09-17 2014-01-01 陈逊 Technology for manufacturing compound planting tooth
US20150164853A1 (en) * 2013-12-12 2015-06-18 Mayo Foundation For Medical Education And Research Prostacyclin compositions for regulation of fracture repair and bone formation
WO2015172101A1 (en) * 2010-10-20 2015-11-12 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
CN105860431A (en) * 2016-04-13 2016-08-17 汪艳 Polyether ether ketone/multi-walled carbon nanotube composite powder material used for selective laser sintering technology, and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582860A (en) * 2003-08-20 2005-02-23 中国科学院金属研究所 Carbon fiber inforced poly(ether-ether-ketone) composite bone fracture plate
CN1593356A (en) * 2004-06-24 2005-03-16 上海交通大学 Whole coxa thighbone prosthesis and method for making same
WO2015172101A1 (en) * 2010-10-20 2015-11-12 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
CN103479443A (en) * 2013-09-17 2014-01-01 陈逊 Technology for manufacturing compound planting tooth
US20150164853A1 (en) * 2013-12-12 2015-06-18 Mayo Foundation For Medical Education And Research Prostacyclin compositions for regulation of fracture repair and bone formation
CN105860431A (en) * 2016-04-13 2016-08-17 汪艳 Polyether ether ketone/multi-walled carbon nanotube composite powder material used for selective laser sintering technology, and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
宋波: "《塑料改性技术》", 31 October 2016, 中国纺织出版社 *
黄龙男: "《聚合物基复合材料科学与工程》", 31 July 2018, 哈尔滨工业大学出版社 *

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Application publication date: 20190426

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