CN109663620A - A kind of closed type micro fluidic device - Google Patents
A kind of closed type micro fluidic device Download PDFInfo
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- CN109663620A CN109663620A CN201910012694.3A CN201910012694A CN109663620A CN 109663620 A CN109663620 A CN 109663620A CN 201910012694 A CN201910012694 A CN 201910012694A CN 109663620 A CN109663620 A CN 109663620A
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- 230000005389 magnetism Effects 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 230000003993 interaction Effects 0.000 abstract description 5
- 239000002390 adhesive tape Substances 0.000 description 14
- 238000010586 diagram Methods 0.000 description 9
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- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
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- 241000208340 Araliaceae Species 0.000 description 1
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- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
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- 238000005530 etching Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
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- 230000005484 gravity Effects 0.000 description 1
- 229910003437 indium oxide Inorganic materials 0.000 description 1
- PJXISJQVUVHSOJ-UHFFFAOYSA-N indium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[In+3].[In+3] PJXISJQVUVHSOJ-UHFFFAOYSA-N 0.000 description 1
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- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
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- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Abstract
The invention discloses a kind of closed type micro fluidic devices, the present invention utilizes the electromagnetism height adjustment module of the height of electromagnetic interaction controlroof by setting, and combine the size of the electric current of adjustable source module control input electromagnetism height adjustment module, realize that ceiling height is adjustable, top plate picks and places easy, overcomes and ceiling height exists in the prior art is difficult to adjust and picks and places the technical problem of inconvenience.
Description
Technical field
The present invention relates to micro-fluidic field, especially a kind of closed type micro fluidic device.
Background technique
Nowadays, digital microcurrent-controlled platform shows its huge development in chemistry, biology, medicine and other every field
Potentiality and application prospect, such as reagent detection, care diagnostic (Point of Care Testing, PoCT).It counts in these areas
Word microfluidic platform all shows excellent performance.Digital microcurrent-controlled platform based on electrowetting is that a kind of microfluidic control is flat
Platform, in platform, liquid is handled as the drop of independent unit-sized, these drops can be distributed from source,
Merge, divide or transported between demand point.These devices can be realized by using surface electrode array or channel, with logical
Electrowetting effect is crossed to control the shape of drop and position.
Open and closed type can be divided into the array structure of digital microcurrent-controlled middle driving drop, compare closed type, it is open
Formula may require that bigger driving voltage often to increase the limitation on drive condition, and high voltage drive is also dangerous.
And closed type is easier to drive drop, however the different height of top plate will affect the effect of driving, and usually add top plate
Mode is that special adhesive tape is sticked in electrod-array surrounding, and operation is inconvenient, and the adjustment of height can not be very fine, top plate
It takes also very troublesome.It specifically, is traditional closed structure side view with reference to Fig. 1 and Fig. 2, Fig. 1；Fig. 2 is traditional closure
Formula structure top view；The traditional approach for adding top plate is especially coarse, and by selecting special adhesive tape, (such as black surround glue, cost are high
And it is inconvenient to use, characteristic and double faced adhesive tape are close, and single layer height is commonly 50 μm or 85 μm.), segmentation is pasted onto electrode
Array surrounding is superimposed adhesive tape further according to the height of needs, then ITO top plate is attached on adhesive tape again, and the adhesive tape to stack up will
Top plate paves a subtle difference in height.Top plate can only be worked under adhesive tape height or its multiple altitudes in this way, nothing
Method obtains the parameter of other height again, and adhesive tape reduction number of plies after several layers of addition is more troublesome, and top plate adjusts inconvenient.
When testing or operating terminates to need replacing drop and other situations, the ito glass top plate that will be sticked on adhesive tape is needed to take off,
Operation is inconvenient in this way, and is easy to take up adhesive tape when removing top plate and is caused on the electrode array strake operated or push up
The AF hydrophobic dielectric film of institute's spin coating is destroyed on plate, causes the damage of device, this damage is irreversible.Sometimes can also pass through
The electrowetting phenomenon of added material (such as silicone oil) Lai Tigao drop on electrod-array operating platform, to reinforce liquid drop movement
Ability, but this can cause to be difficult to stick adhesive tape on electrod-array operating platform, or driving top plate to shift influences liquid
Drop.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.For this purpose, of the invention
One purpose is to provide a kind of closed type micro fluidic device, utilizes the height of electromagnetic force controlroof.
The technical scheme adopted by the invention is that: a kind of closed type micro fluidic device, including top plate, adjustable source module
With the electromagnetism height adjustment module of the height for controlling the top plate using electromagnetic interaction, the adjustable source mould
The output end of block is connect with the input terminal of the electromagnetism height adjustment module.
Further, the closed type micro fluidic device further includes parallel output module, the adjustable source module
Output end is connect with the input terminal of the parallel output module, the output end of the parallel output module and the electromagnetism height tune
Save the input terminal connection of module.
Further, the closed type micro fluidic device further includes Voltage to current transducer module, the parallel output module
Output end connect with the input terminal of the Voltage to current transducer module, the output end of the Voltage to current transducer module with it is described
The input terminal of electromagnetism height adjustment module connects.
Further, the closed type micro fluidic device further includes parallel output control module, the parallel output control
The output end of module is connect with the input terminal of the parallel output module.
Further, the electromagnetism height adjustment module includes electromagnet and the magnet that is arranged on the top plate, described
The output end of adjustable source module is connect with the input terminal of the electromagnet, the magnetism and the magnetic of the magnet of the electromagnet
Property on the contrary, realize the opposite sex repel each other to raise the top plate.
Further, the electromagnetism height adjustment module further includes electromagnetism height adjustment platform, and the electromagnet setting exists
On the electromagnetism height adjustment platform.
Further, multiple drop coordination electrodes are provided on the electromagnetism height adjustment platform.
Further, the closed type micro fluidic device further includes droplet manipulation platform, is set on the droplet manipulation platform
Multiple drop coordination electrodes are equipped with, the droplet manipulation platform is arranged on the electromagnetism height adjustment platform.
Further, the material of the droplet manipulation platform includes ITO electro-conductive glass, PCB circuit board or paper.
Further, the electromagnetism height adjustment module includes electromagnet and has the magnetic top plate, described adjustable
The output end of economize on electricity source module is connect with the input terminal of the electromagnet, the magnetism and the magnetic phase of the top plate of the electromagnet
Instead, realize that the opposite sex is repelled each other to raise the top plate.
The beneficial effects of the present invention are:
The present invention utilizes the electromagnetism height adjustment module of the height of electromagnetic interaction controlroof by setting, and ties
The size for closing the electric current of adjustable source module control input electromagnetism height adjustment module, realizes that ceiling height is adjustable, top plate
It picks and places easy, overcomes and ceiling height exists in the prior art be difficult to adjust and picks and places the technical problem of inconvenience.
In addition, the present invention also passes through setting parallel output module, realize control signal parallel output to control multiple electromagnetism
Iron.
Detailed description of the invention
Fig. 1 is traditional closed structure side view；
Fig. 2 is traditional closed structure top view；
Fig. 3 is an a kind of specific embodiment structural block diagram of closed type micro fluidic device of the present invention；
Fig. 4 is an a kind of specific embodiment side schematic view of closed type micro fluidic device of the present invention；
Fig. 5 is an a kind of specific embodiment connection schematic diagram of closed type micro fluidic device of the present invention；
Fig. 6 is a kind of drop control platform of closed type micro fluidic device of the present invention and a tool of electromagnetism height adjustment platform
Body embodiment schematic diagram；
Fig. 7 a, Fig. 7 b, Fig. 7 c are that an a kind of specific embodiment drop of closed type micro fluidic device of the present invention is drivingly connected
Schematic diagram；
Fig. 8 a, Fig. 8 b, Fig. 8 c are a kind of specific embodiment drop driving signals of closed type micro fluidic device of the present invention
Figure.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.
A kind of closed type micro fluidic device, including top plate, adjustable source module (the adjustable section of output voltage, output
Current adjustment section) and for using electromagnetic interaction controlroof height electromagnetism height adjustment module, adjustable economize on electricity
The output end of source module is connect to input adjustable electric current with the input terminal of electromagnetism height adjustment module.Electromagnetism height adjustment mould
Block obtains height that is electric and passing through electromagnetic suspension principle controlroof, passes through the size of current of control input electromagnetism height adjustment module
The height of top plate can be fine-tuned, realize accurate increase or reduces ceiling height.It is controlled by electromagnetic interaction
The height of top plate, cumbersome preparation process and high special adhesive tape needed for eliminating the setting of conventional upper height, top plate
Pick-and-place be not easy to influence drop, will not more be deviated because of top plate or while removing top plate tear adhesive tape and destroy and be spun on top
The drain insulating layer of plate surface, top plate take conveniently, and cost is high and time saving saving, flexible operation.Specifically, electromagnetism height tune
Section module, which can be, raises top plate by the electromagnetic force repelled each other of the opposite sex or the attracting electromagnetic force of the same sex draws top
Plate is to increase top plate.
Further, closed type micro fluidic device further includes parallel output module, the output end of adjustable source module with
The input terminal of parallel output module connects, and the output end of parallel output module is connect with the input terminal of electromagnetism height adjustment module,
Parallel output module exports for realizing voltage in parallel or electric current parallel output.It is a kind of closure of the present invention with reference to Fig. 3, Fig. 3
Decline a specific embodiment structural block diagram of flow control apparatus；When parallel output modular concurrent output voltage, it is also necessary to be arranged one
A Voltage to current transducer module is to realize the conversion of voltage and current；In order to control the work of parallel output module, it is also provided with
The output end of parallel output control module, parallel output control module is connect with the input terminal of parallel output module, parallel output
The output end of module is connect with the input terminal of Voltage to current transducer module, the output end and electromagnetism height of Voltage to current transducer module
The input terminal of adjustment module connects.Specifically, the voltage range of adjustable source module is 5V to 250V, the size of output voltage
It is adjustable, that is, export the adjustable section of electric current；Parallel output control module uses STM32 chip, can be used
The chip of STM32F103CBT6 model；The composition of Voltage to current transducer module can be using electric pressure converter, be also possible to make
Voltage-current converter circuit is formed with resistance, diode etc..Parallel output module includes HV513 high pressure parallel output chip, should
Chip works under low pressure, and the voltage that adjustable source module inputs is exported according to program parallelization；HV513 chip has 8 tunnels electric
Parallel output mouth is pressed, output voltage range 5V-250V, which itself does not increase voltage, according to the finger of STM32 chip
It enables and requires (position of the voltage output of specified HIV513 chip and corresponding output voltage) by the voltage of input in unit
It is exported as requested in time to voltage output, voltage output output voltage to Voltage to current transducer module.Voltage and current
The voltage that HV513 chip exports is converted to electric current and exported to electromagnetism height adjustment module by conversion module, makes electromagnetism height adjustment
Module generates magnetic force to change the height of top plate.Since the adjustable extent of the output voltage of adjustable source module is wide, pass through
Voltage-current converter circuit is converted to corresponding current, can carry out intense adjustment to the height of top plate.In addition, it is also necessary to be set as simultaneously
The power module of voltage regulation of row output control module and parallel output module for power supply, power module of voltage regulation is by groups such as ME6208A33M3G
At voltage-stabilizing system realize, the 5V of input is switched into 3.3V.
Further, electromagnetism height adjustment module includes electromagnet and the magnet that is arranged on top plate, with reference to Fig. 4 and Fig. 5,
Fig. 4 is an a kind of specific embodiment side schematic view of closed type micro fluidic device of the present invention, and Fig. 5 is a kind of closed type of the present invention
One specific embodiment connection schematic diagram of micro fluidic device；Magnet is bumped into top plate by etching, Voltage to current transducer module
The connection of the input terminal of output end and electromagnet is with input current, and the magnetism of electromagnet is with the magnetism of magnet on the contrary, realizing anisotropic phase
Reprimand is to raise top plate.Adjustable voltage is converted into electric current and exported to electromagnetism height adjustment module by Voltage to current transducer module
Electromagnet；So that it is generated inserted magnet generation repulsion in polarity and top plate and lift top plate, to adjust ceiling height.Output electricity
It presses range wide, corresponding current is converted to by Voltage to current transducer module, finely ceiling height can be adjusted；Because of closure
The digital microcurrent-controlled device of formula does not need top plate raising how many, highly by μm as unit of, so not needing too high power
Satisfaction can lift slightly top plate, and the gravity of top plate itself and the power of electromagnetic suspension are formed and balanced, and top plate is allowed to be not easy to incline
Tiltedly.
It further, is a kind of drop control of closed type micro fluidic device of the present invention with reference to Fig. 4, Fig. 5 and Fig. 6, Fig. 6
One specific embodiment schematic diagram of platform and electromagnetism height adjustment platform；Electromagnetism height adjustment module further includes electromagnetism height adjustment
Platform, closed type micro fluidic device further include droplet manipulation platform.Electromagnetism height adjustment platform and droplet manipulation platform provide two
Kind implementation,
The first implementation: referring to Fig. 6, and both electromagnetism height adjustment platform and droplet manipulation platform can separate, electricity
Magnet is arranged on electromagnetism height adjustment platform, and multiple drop coordination electrodes are provided on droplet manipulation platform, and droplet manipulation is flat
Platform (droplet manipulation platform is realized using ito glass in Fig. 6) is arranged on electromagnetism height adjustment platform, and tabletting can be used
Droplet manipulation platform is fixed on electromagnetism height adjustment platform by folder, adhesive tape etc..
Second of implementation: referring to Fig. 5, is also possible to both electromagnetism height adjustment platform and droplet manipulation platform one
Change, the two can not mutually interfere with each other normal performance to be also possible in different circuit systems in same circuit system；If the two
It is not identical material, can be used that technique is inlayed or other technologies form integration, in protection scope, in Fig. 5,
Electromagnetism height adjustment platform and droplet manipulation platform are in same circuit system.Electromagnet is embedded in electromagnetism height adjustment platform
On, multiple drop coordination electrodes are provided on electromagnetism height adjustment platform.
In addition, another implementation of electromagnetism height adjustment module: electromagnetism height adjustment module includes being arranged in electromagnetism
Electromagnet and the magnetic top plate of tool on height adjustment platform, the input of the output end and electromagnet of Voltage to current transducer module
End connection, the magnetism of electromagnet is with the magnetism of top plate on the contrary, realizing that the opposite sex is repelled each other to raise top plate.
And the material of droplet manipulation platform includes that (paper is micro-fluidic used for ITO electro-conductive glass, PCB circuit board or paper
Paper base).Electromagnet quantity and position are unrestricted, but must be electromagnetism height adjustment platform, droplet manipulation platform, top plate three
Between do not have bad mutual interference, and can make top plate suspend keep balance.Wherein, top plate, which can be, is etched by ito glass and is inlayed
Electromagnet, ITO are indium oxide layer tin (electrically conducting transparents), and depending on the ITO pattern of top plate is as needed, top plate is generally in closed type
In serve as earth polar, be the one of a kind of closed type micro fluidic device of the present invention with reference to Fig. 7 a, Fig. 7 b and Fig. 7 c, Fig. 7 a, Fig. 7 b, Fig. 7 c
Specific embodiment drop is drivingly connected schematic diagram；When drop drives, top plate needs to be grounded.
With reference to Fig. 5 and Fig. 6, droplet manipulation platform or electromagnetism height adjustment platform possess to be connect with what drop drive module was connected
Mouthful, when droplet manipulation platform and electromagnetism height adjustment platform are the integrated design, electromagnetism height adjustment platform can be production
At the form being connected with drop drive module, the interface and on-fixed of use, the row's of can be needle, FPC soft arranging wire (as shown in Figure 5)
Etc..When droplet manipulation platform and electromagnetism height adjustment platform are not the integrated design, it is set on droplet manipulation platform
The connected interface of drop drive module, such as the FPC soft arranging wire of Fig. 6.
With reference to Fig. 5, drop is on the drop coordination electrode array on electromagnetism height adjustment platform, in drop coordination electrode
Coating can have hydrophobic dielectric substance layer or a film to be any, it is depending on the circumstances, meet dielectric electro-wetting principle all
It is applicable；Such as AF Teflon, Cytop, PDMS, Parafilm M.The shape of drop coordination electrode have no it is specified, it is either traditional
The electrode shapes such as the rectangle of type, half selenodont or annular saw flute profile are eligible.Drop drive module is according to demand to drop
It is controlled, control flow is as follows: with reference to Fig. 3, starting parallel output control module, adjustable source module, parallel output mould
Block and Voltage to current transducer module instill after drop in drop coordination electrode, top plate are directly added, with specific reference to Fig. 4；Ginseng
Examine Fig. 7 a, Fig. 7 b, Fig. 7 c, Fig. 8 a, Fig. 8 b and Fig. 8 c, Fig. 8 a, Fig. 8 b, Fig. 8 c are a kind of closed type micro fluidic devices of the present invention
One specific embodiment drop drives schematic diagram, and drop drive module applies different voltage in different drop coordination electrodes,
Such as 0V and 40V to drive drop mobile.
It is to be illustrated to preferable implementation of the invention, but the invention is not limited to the implementation above
Example, those skilled in the art can also make various equivalent variations on the premise of without prejudice to spirit of the invention or replace
It changes, these equivalent deformations or replacement are all included in the scope defined by the claims of the present application.
Claims (10)
1. a kind of closed type micro fluidic device, which is characterized in that including top plate, adjustable source module and for utilizing electromagnetism phase
Interreaction force controls the electromagnetism height adjustment module of the height of the top plate, the output end of the adjustable source module with it is described
The input terminal of electromagnetism height adjustment module connects.
2. closed type micro fluidic device according to claim 1, which is characterized in that the closed type micro fluidic device also wraps
Parallel output module is included, the output end of the adjustable source module is connect with the input terminal of the parallel output module, described
The output end of parallel output module is connect with the input terminal of the electromagnetism height adjustment module.
3. closed type micro fluidic device according to claim 2, which is characterized in that the closed type micro fluidic device also wraps
Include Voltage to current transducer module, the input terminal company of the output end of the parallel output module and the Voltage to current transducer module
It connects, the output end of the Voltage to current transducer module is connect with the input terminal of the electromagnetism height adjustment module.
4. closed type micro fluidic device according to claim 2, which is characterized in that the closed type micro fluidic device also wraps
Include parallel output control module, the input terminal company of the output end of the parallel output control module and the parallel output module
It connects.
5. closed type micro fluidic device according to any one of claims 1 to 4, which is characterized in that the electromagnetism height tune
Save the magnet that module includes electromagnet and is arranged on the top plate, the output end and the electromagnetism of the adjustable source module
The input terminal of iron connects, and the magnetism of the electromagnet is with the magnetism of the magnet on the contrary, realizing that the opposite sex is repelled each other to raise the top
Plate.
6. closed type micro fluidic device according to claim 5, which is characterized in that the electromagnetism height adjustment module is also wrapped
Electromagnetism height adjustment platform is included, the electromagnet is arranged on the electromagnetism height adjustment platform.
7. closed type micro fluidic device according to claim 6, which is characterized in that set on the electromagnetism height adjustment platform
It is equipped with multiple drop coordination electrodes.
8. closed type micro fluidic device according to claim 6, which is characterized in that the closed type micro fluidic device also wraps
Droplet manipulation platform is included, multiple drop coordination electrodes, the droplet manipulation platform setting are provided on the droplet manipulation platform
On the electromagnetism height adjustment platform.
9. closed type micro fluidic device according to claim 8, which is characterized in that the material packet of the droplet manipulation platform
Include ITO electro-conductive glass, PCB circuit board or paper.
10. closed type micro fluidic device according to any one of claims 1 to 4, which is characterized in that the electromagnetism height tune
Section module includes electromagnet and the magnetic top plate of tool, output end and the electromagnet of the adjustable source module
Input terminal connection, the magnetism of the electromagnet is with the magnetism of the top plate on the contrary, realizing that the opposite sex is repelled each other to raise the top plate.
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| CN201910012694.3A CN109663620A (en) | 2019-01-07 | 2019-01-07 | A kind of closed type micro fluidic device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910012694.3A CN109663620A (en) | 2019-01-07 | 2019-01-07 | A kind of closed type micro fluidic device |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975120A2 (en) * | 2007-03-29 | 2008-10-01 | FUJIFILM Corporation | Microchemical chip and method for fabricating the same |
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-
2019
- 2019-01-07 CN CN201910012694.3A patent/CN109663620A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975120A2 (en) * | 2007-03-29 | 2008-10-01 | FUJIFILM Corporation | Microchemical chip and method for fabricating the same |
| CN108479875A (en) * | 2018-06-01 | 2018-09-04 | 东莞东阳光科研发有限公司 | A kind of digital microcurrent-controlled chip report control platform |
| CN209829007U (en) * | 2019-01-07 | 2019-12-24 | 深圳市国华光电科技有限公司 | Closed micro-fluidic device |
Non-Patent Citations (1)
| Title |
|---|
| 王立鼎，刘冲，徐征: "SOPC设计基础与实践", 31 January 2017, 西安电子科技大学出版社, pages: 404 - 156 * |
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