CN109646705A - Composite sponge and preparation method thereof and negative pressure drainage dressing, device and Medical Devices - Google Patents
Composite sponge and preparation method thereof and negative pressure drainage dressing, device and Medical Devices Download PDFInfo
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- CN109646705A CN109646705A CN201910090948.3A CN201910090948A CN109646705A CN 109646705 A CN109646705 A CN 109646705A CN 201910090948 A CN201910090948 A CN 201910090948A CN 109646705 A CN109646705 A CN 109646705A
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- China
- Prior art keywords
- alginic acid
- composite sponge
- sponge
- polyvinyl alcohol
- composite
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- 239000002131 composite material Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 38
- 229920000615 alginic acid Polymers 0.000 claims abstract description 38
- 239000000783 alginic acid Substances 0.000 claims abstract description 37
- 229960001126 alginic acid Drugs 0.000 claims abstract description 37
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 32
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 32
- -1 alginic acid ester Chemical class 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 7
- 238000004132 cross linking Methods 0.000 claims abstract description 7
- 239000003377 acid catalyst Substances 0.000 claims abstract description 5
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 5
- 239000004088 foaming agent Substances 0.000 claims abstract description 5
- 239000004094 surface-active agent Substances 0.000 claims abstract description 5
- 150000004781 alginic acids Chemical class 0.000 claims description 14
- 238000010792 warming Methods 0.000 claims description 12
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims description 6
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims description 6
- 230000032050 esterification Effects 0.000 claims description 5
- 238000005886 esterification reaction Methods 0.000 claims description 5
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 4
- 238000006136 alcoholysis reaction Methods 0.000 claims description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 4
- 229950007687 macrogol ester Drugs 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 32
- 206010052428 Wound Diseases 0.000 abstract description 19
- 208000027418 Wounds and injury Diseases 0.000 abstract description 19
- 239000002253 acid Substances 0.000 abstract description 3
- 239000012467 final product Substances 0.000 abstract description 3
- 230000001376 precipitating effect Effects 0.000 abstract description 3
- 230000008859 change Effects 0.000 abstract description 2
- 238000001704 evaporation Methods 0.000 abstract description 2
- 230000008020 evaporation Effects 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract 1
- 230000000116 mitigating effect Effects 0.000 abstract 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 24
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 15
- 238000000034 method Methods 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940015043 glyoxal Drugs 0.000 description 3
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 239000003519 biomedical and dental material Substances 0.000 description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01042—Absorbency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
The invention discloses preferable composite sponge of a kind of water-retaining property and preparation method thereof and negative pressure drainage dressing, device and Medical Devices.The composite sponge includes following components: alginic acid ester, polyvinyl alcohol, foaming agent, surfactant, crosslinking agent, acid catalyst, deionized water.The preparation method of the composite sponge stirs the following steps are included: by alginic acid ester, polyvinyl alcohol and deionized water；Sequentially add foaming agent, surfactant, crosslinking agent, acid catalyst, mixing, cooling pour into mold, carry out cross-linking reaction after stirring, cooling and demolding is cleaned to obtain the final product.Alginic acid ester of the present invention will not generate precipitating in acid solution, sponge can be promoted utmostly to promote its water retention property, reduce the moisture evaporation of composite sponge in use, change the hardness of dry state composite sponge, dry state sponge is reduced to the oppressive force of wound, the pain for mitigating patient, accelerates the healing process of wounds.
Description
Technical field
The present invention relates to technical field of biomedical materials, more particularly, to a kind of composite sponge and preparation method thereof and bear
Pressure drainage dressing, device and Medical Devices.
Background technique
Negative pressure drainage Wound treating technology is one developed in recent years for treating the new technology of the surface of a wound, various
It is largely used in the Wound treatings such as acute injury, skin tissue defects, burn wound, chronic wound surface in refractory to treatment.Its cardinal principle
It is the surface of a wound by the interior dressing covering for setting drainage tube or filling skin, soft tissue defects, then it is sealed with biological semi-permeable film
It closes, makes a confined space, drainage tube is finally connected into negative pressure source, intermittently or constantly generated at the surface of a wound negative
Pressure, to stimulate granulation tissue growth, wound healing.
Bio-medical material has many advantages, such as efficient, economical as a kind of novel hemostatic material, is that the negative pressure drainage surface of a wound is controlled
Conventional dressing in treatment technology.Relatively common bio-medical material is polyvinylalcohol sponge, although polyvinyl alcohol is with extremely strong
Water absorbing properties, but merely the sponge as made from polyvinyl alcohol under the action of negative pressure be easy be hardened, oppress the surface of a wound and influence
It uses, therefore, researcher attempts to use some other material compound to improve performance with its, these materials include alginic acid
Salt, chitosan etc..Wherein, with alginate for main composite material.But it is found in actual surgical procedure, this alginic acid
Salt-polyvinyl alcohol compound sponges material is still easy dehydration during negative pressure drainage and is hardened, and is unable to reach theoretic expection
Water-saving effect.Therefore, it is necessary to provide, a kind of water-retaining property is preferable, is not easy the sponge material being hardened.
Summary of the invention
A technical problem to be solved by this invention is how to provide a kind of preferable composite sponge of water-retaining property and its system
Preparation Method and negative pressure drainage dressing, device and Medical Devices.
According to the first aspect of the invention, the invention proposes a kind of composite sponges, according to an embodiment of the invention, should
Composite sponge includes following components according to mass fraction:
In addition, according to an embodiment of the invention, the composite sponge can also have following additional technical feature:
In some embodiments of the invention, alginic acid ester is alginic acid macrogol ester, alginic acid lauryl, alginic acid
At least one of monooctyl ester, propylene glycol alginate, alginic acid hexadecyl ester.
In some embodiments of the invention, the esterification degree of alginic acid ester is 10-25%.
In some embodiments of the invention, the alcoholysis degree of polyvinyl alcohol is 85-99%.
In some embodiments of the invention, the average molecular weight of polyvinyl alcohol is 110000-200000.
In some embodiments of the invention, foaming agent is saleratus, in ammonium hydrogen carbonate, sodium bicarbonate, calcium bicarbonate
At least one.
In some embodiments of the invention, surfactant is alkyl phenol polyoxyethylene ether, lauryl sodium sulfate, ten
At least one of dialkyl benzene sulfonic acids sodium.
In some embodiments of the invention, crosslinking agent is at least one of glutaraldehyde, formaldehyde, glyoxal.
In some embodiments of the invention, acid catalyst is at least one of phosphoric acid, hydrochloric acid, sulfuric acid, nitric acid.
According to the second aspect of the invention, the invention proposes a kind of preparation methods of above-mentioned composite sponge.According to this
The embodiment of invention, method includes the following steps:
S1: by alginic acid ester, polyvinyl alcohol and deionized water, system A is mixed to get under the conditions of 70-100 DEG C；
S2: foaming agent and surfactant are added in system A, is mixed to get system B；
S3: system B is cooled to 45-55 DEG C, crosslinking agent is added, is mixed to get system C；
S4: system C is cooled to 35-45 DEG C, acid catalyst is added, is mixed to get system D；
S5: pouring into mold for system D, and cross-linking reaction 5-10h is carried out at 40-90 DEG C, and cooling and demolding is cleaned to obtain the final product.
In some embodiments of the invention, step S1 specifically: stir alginic acid rouge, polyvinyl alcohol, deionized water
Uniformly, it is warming up to 70-100 DEG C, lasting stirring dissolves alginic acid rouge and polyvinyl alcohol all, obtains system A.
In some embodiments of the invention, step S1 specifically: alginic acid ester and deionized water are mixed and are warming up to 70-
100 DEG C obtain the first solution, are warming up to 70-100 DEG C and obtain the second solution polyvinyl alcohol and deionized water mixing, molten by first
Liquid and the second solution are mixed to get system A；Wherein, the deionized water in the deionized water and the second solution in the first solution is respectively
A part of deionized water total amount in step S1 specifically can be and respectively refer to the alginic acid with can at least make in the first solution
The amount that polyvinyl alcohol in ester and the second solution is completely dissolved.
According to the third aspect of the present invention, the invention proposes a kind of negative pressure drainage dressing, implementations according to the present invention
Example, which includes above-mentioned composite sponge；For example, the negative pressure drainage dressing can specifically include above-mentioned composite sponge
And the drainage tube including being embedded in composite sponge.
According to the fourth aspect of the present invention, the invention proposes a kind of negative pressure drainage device, implementations according to the present invention
Example, which includes above-mentioned composite sponge；It specifically can be the negative pressure drainage dress including above-mentioned negative pressure drainage dressing
It sets；For example, the negative pressure drainage device can specifically include drainage machine host, negative pressure drainage external member, administration lavage apparatus etc., negative pressure
Drainage kit may include negative pressure sucker, drainage tube and composite sponge etc..
According to the fifth aspect of the present invention, the invention proposes a kind of Medical Devices, according to an embodiment of the invention, should
Medical Devices include above-mentioned composite sponge, specifically be can be individually including above-mentioned composite sponge or including above-mentioned negative pressure drainage dressing
Or the Medical Devices including above-mentioned negative pressure drainage device including any, can be implemented separately negative pressure drainage technology or with other skills
Art, which combines, realizes more complicated operation and therapeutic process.
The medicine have the advantages that
It is inventors have found that sodium alginate-polyvinyl alcohol composite sponge is unable to reach the reason of expected water retention property,
Although sodium alginate on strand containing great amount of hydroxy group to guarantee its hydrophily, the alginic acid easy to form when pH is lower than 6
Gel and precipitating is precipitated so that the sponge aperture that is prepared is uneven, in addition also result in sponge products in water retention property
On certain missing, and then in use be easy dehydration be hardened.And alginic acid ester of the present invention is usually to utilize
Reacting between alginic acid and alcohol molecule is made, with excellent emulsibility, thickening property and acid resistance, in the acid of pH value 3-4
Property solution in will form gel, but not therefore generate precipitating.So alginic acid ester can promote sponge foaming mistake in the preparation
The stabilization of bubble in journey.The sponge being prepared also can utmostly promote its water retention property, reduce composite sponge and using
Moisture evaporation in the process changes the hardness of dry state composite sponge, reduces dry state sponge to the oppressive force of wound, mitigates patient's
Pain.
In addition, the emulsibility and thickening property of alginic acid ester keep the micro-bubble hole in the composite sponge obtained after being added uniform
Connection, is conducive to the discharge of sepage during clinical use, accelerates the rehabilitation course of patient.
Patient can be advantageously promoted using negative pressure drainage dressing, negative pressure drainage device and the Medical Devices of the composite sponge
The treatment of the surface of a wound.
Detailed description of the invention
Fig. 1 is the scanning of sponge made from method in the comparative experiments of one embodiment of the present of invention according to comparative example 1
Electron microscope.
Fig. 2 is the scanning for the sponge being prepared Following the procedure of Example 1 in the comparative experiments of one embodiment of the present of invention
Electron microscope.
Fig. 3 is the water-retaining property of sponge made from comparative example 1 and embodiment 1 in the comparative experiments of one embodiment of the present of invention
It can comparison result figure.
Fig. 4 is the mechanical property of sponge made from comparative example 1 and embodiment 1 in the comparative experiments of one embodiment of the present of invention
It can comparison result figure.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment to design of the invention, specific structure and generation clear, complete
Ground description, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is of the invention one
Section Example, rather than whole embodiments, based on the embodiment of the present invention, those skilled in the art are not paying creativeness
Other embodiments obtained, belong to the scope of protection of the invention under the premise of labour.
Embodiment 1
A kind of composite sponge includes following components according to its mass fraction:
The esterification degree of above-mentioned propylene glycol alginate is 25%, and the average molecular weight of polyvinyl alcohol is 110000, alcoholysis degree
For 85-99%.
The specific preparation method of the composite sponge includes the following steps:
Step 1: propylene glycol alginate, polyvinyl alcohol and deionized water being uniformly mixed, are warming up to 90 DEG C, is continued
Stirring dissolves propylene glycol alginate and polyvinyl alcohol all, and system A is made；
Step 2: sodium bicarbonate, lauryl sodium sulfate are added into system A, stirs 30min, stirring rate 1300rpm,
System B is made；
Step 3: system B being cooled to 50 DEG C, glyoxal is added, stirs 15min, stirring rate 1500rpm, system is made
C；
Step 4: system C being cooled to 40 DEG C, hydrochloric acid is added, stirs 8min, stirring rate 1500rpm, system D is made；
Step 5: system D is poured into mold after mixing evenly, 70 DEG C cross-linking reaction 5 hours, demould cleaning after cooling,
Up to composite sponge.
Embodiment 2
A kind of composite sponge includes following components according to its mass fraction:
The specific preparation method of the composite sponge includes the following steps:
Step 1: propylene glycol alginate and appropriate amount of deionized water being uniformly mixed, 80 DEG C is warming up to and is prepared into first
Solution, polyvinyl alcohol are uniformly mixed with remaining deionized water, are warming up to 90 DEG C and are prepared into the second solution, and lasting stirring makes the
One solution is uniformly mixed with the second solution, and system A is made；
Step 2: sodium bicarbonate, calcium bicarbonate, neopelex being added into system A, stirs 15min, stirring
System B is made in rate 1400rpm；
Step 3: system B being cooled to 50 DEG C, glutaraldehyde is added, stirs 20min, stirring rate 1600rpm, system is made
C；
Step 4: system C being cooled to 40 DEG C, sulfuric acid is added, stirs 5min, stirring rate 1600rpm, system D is made；
Step 5: system D is poured into mold after mixing evenly, 80 DEG C cross-linking reaction 4.5 hours, demould cleaning after cooling,
Up to composite sponge.
Embodiment 3
A kind of composite sponge includes following components according to its mass fraction:
The specific preparation method of the composite sponge includes the following steps:
Step 1: alginic acid macrogol ester, polyvinyl alcohol and deionized water being uniformly mixed, 90 DEG C is warming up to, holds
Continuous stirring dissolves alginic acid macrogol ester and polyvinyl alcohol all, and system A is made；
Step 2: ammonium hydrogen carbonate, alkyl phenol polyoxyethylene ether being added into system A, stirs 45min, stirring rate
System B is made in 1400rpm；
Step 3: system B being cooled to 50 DEG C, formaldehyde is added, stirs 20min, stirring rate 1100rpm, system C is made；
Step 4: system C being cooled to 40 DEG C, phosphoric acid is added, stirs 15min, stirring rate 1100rpm, system D is made；
Step 5: system D is poured into mold after mixing evenly, 60 DEG C cross-linking reaction 7 hours, demould cleaning after cooling,
Up to composite sponge.
Embodiment 4
Performance comparison test
Comparative example 1: the sponge is prepared by the following method, and wherein percentage indicates that the quality of each component accounts for the hundred of gross mass
Score:
Step 1: 13% polyvinyl alcohol and 73.2% deionized water being uniformly mixed, 90 DEG C is warming up to, persistently stirs
Mixing dissolves polyvinyl alcohol all, and poly-vinyl alcohol solution is made；
Step 2: 0.3% sodium bicarbonate, 0.5% lauryl sodium sulfate, stirring being added into poly-vinyl alcohol solution
30min, stirring rate 1300rpm obtain system B；
Step 3: system B being cooled to 50 DEG C, 7% glyoxal is added, stirs 15min, stirring rate 1500rpm is obtained
To system C；
Step 4: system C being cooled to 40 DEG C, 6% hydrochloric acid is added, stirs 8min, stirring rate 1500rpm obtains body
It is D；
Step 5: system D is poured into mold after mixing evenly, 70 DEG C cross-linking reaction 5 hours, demould cleaning after cooling,
To obtain the final product.
The average molecular weight of used polyvinyl alcohol is 110000, alcoholysis degree 85-99%.
1. morphology observation
It is fixed on sample stage after being respectively freeze-dried comparative example 1 and the obtained sponge of embodiment 1 in freeze dryer,
On surface, metal spraying is placed on Electron Microscopy Room, observes the surface topography of sponge.Fig. 1 is the scanning electron microscope (SEM) photograph of sponge made from comparative example 1,
As shown in Figure 1, its flat structure of micro-bubble hole near sponge large aperture crafters made from comparative example 1, different levels
Micro-bubble hole is individually layered, each other mutually isolation, is in two-dimensional sheet.Fig. 2 is the scanning electricity of sponge made from embodiment 1
Mirror figure, as shown in Fig. 2, the micro-bubble pore structure of the inside of composite sponge made from embodiment 1 different levels is interconnected, aperture
Uniformly, the complex porous structure to communicate with each other on three-dimensional space is formed, there is very more open-celled structures, this three-dimensional phase interconnects
Logical porous structure can also promote the discharge of wound exudate in use, accelerate the treatment and health of wounds wound
It is multiple.
2. water retention property compares
Sponge made from comparative example 1 and embodiment 1 is cut into 15 × 15 × 1cm size, weighs and be recorded as the sea of 0h
Continuous weight is subsequently placed in measure its weight per hour in 37 DEG C of baking ovens and record sponge weight and change with time, curve obtained
As shown in Figure 3, wherein circular dot indicates that the weight of embodiment 1, square dot indicate the weight of comparative example 1.It can from figure
Out: in the unit time, the weight of the sponge decline of embodiment 1 is less, i.e., the moisture that embodiment 1 is volatilized in the unit time is less,
That is, 1 gained sponge of embodiment has better water-retaining property compared to comparative example 1.
3. Mechanics Performance Testing (resistance to compression compression deformation):
The sample for taking 50 × 50mm of sponge made from comparative example 1 and embodiment 1 respectively, by ASTM D3574-
Method as defined in 2011Test C is tested, and compressing force of sponge under the conditions of relative deformation 50% is measured.Fig. 4 is the present invention
One embodiment sponge mechanical property comparison result figure, as shown in figure 4, under conditions of relative deformation 50% occurs,
The sponge of embodiment 1 is needed to apply relatively much bigger compressing force, in other words, under identical condition of negative pressure, embodiment 1
Sponge less deformation can occur, this can also be further ensured that the drainage tube hair being embedded in during negative pressure drainage in sponge
A possibility that raw blocking, is smaller, is conducive to the discharge of wound exudate.
Embodiment 5
A kind of composite sponge, the difference from embodiment 1 is that, the alginic acid ester used is alginic acid lauryl, esterification
Degree is 10-15%.Composite sponge obtained equally has good water retention property.
Embodiment 6
A kind of composite sponge, the difference from embodiment 1 is that, the alginic acid ester used is alginic acid hexadecyl ester, esterification
Degree is 15-18%, and the average molecular weight of polyvinyl alcohol is 180000.Composite sponge obtained equally has good water-retaining property
Energy.
A kind of negative pressure drainage dressing, including above-mentioned composite sponge and at least one drainage catheter, the drainage catheter one end are inserted
Enter in composite sponge, the other end is connected with negative pressure source.
A kind of negative pressure drainage device, including drainage machine host, negative pressure drainage external member and administration lavage apparatus, the negative pressure drainage
External member includes negative pressure sucker, above-mentioned composite sponge and the sensor for detecting surface of a wound parameter, and sensor is set to negative pressure sucker
And/or on composite sponge.Negative pressure drainage external member receives surface of a wound parameter, and is sent to drainage machine host processing, drains at machine host
After reason, lavation signal is issued to administration lavage apparatus.
A kind of Medical Devices, including above-mentioned negative pressure drainage device and organization engineering skin construct instrument packet, for example, can join
According to patent CN206103015U.
On be to be illustrated to presently preferred embodiments of the present invention, but the present invention is not limited to the embodiment, it is ripe
Various equivalent deformation or replacement can also be made on the premise of without prejudice to spirit of the invention by knowing those skilled in the art, these
Equivalent deformation or replacement is all included in the scope defined by the claims of the present application.
Claims (10)
1. a kind of composite sponge, which is characterized in that according to mass fraction by including that the raw material of following components is made:
2. composite sponge according to claim 1, which is characterized in that the alginic acid ester be alginic acid macrogol ester,
At least one of alginic acid lauryl, alginic acid monooctyl ester, propylene glycol alginate, alginic acid hexadecyl ester.
3. composite sponge according to claim 1, which is characterized in that the esterification degree of the alginic acid ester is 10-25%.
4. composite sponge according to claim 1, which is characterized in that the alcoholysis degree of the polyvinyl alcohol is 85-99%.
5. composite sponge according to claim 1, which is characterized in that the average molecular weight of the polyvinyl alcohol is
110000-200000。
6. the preparation method of the described in any item composite sponges of claim 1-5, which comprises the following steps:
S1: taking alginic acid ester, polyvinyl alcohol and deionized water, be warming up to 70-100 DEG C, is mixed to get system A；
S2: foaming agent and surfactant are added in the system A, is mixed to get system B；
S3: the system B is cooled to 45-55 DEG C, crosslinking agent is added, is mixed to get system C；
S4: the system C is cooled to 35-45 DEG C, acid catalyst is added, is mixed to get system D；
S5: carrying out cross-linking reaction 5-10h for the system D at 40-90 DEG C, cooling.
7. the preparation method of composite sponge according to claim 6, which is characterized in that the S1 specifically:
The alginic acid rouge, the polyvinyl alcohol, the deionized water are uniformly mixed, are warming up to 70-100 DEG C, makes the sea
Alginic acid rouge and the polyvinyl alcohol all dissolve, and obtain system A；
Or
The alginic acid ester and deionized water mixing are warming up to 70-100 DEG C and obtain the first solution, by the polyvinyl alcohol
70-100 DEG C is warming up to deionized water mixing and obtains the second solution, and first solution and second solution are mixed
Obtain system A；
Any one of.
8. a kind of negative pressure drainage dressing, which is characterized in that including the described in any item composite sponges of claim 1-5.
9. a kind of negative pressure drainage device, which is characterized in that including the described in any item composite sponges of claim 1-5.
10. a kind of Medical Devices, which is characterized in that including the described in any item composite sponges of claim 1-5.
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