CN109636901A - A kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma - Google Patents
A kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 title claims abstract description 12
- 206010061306 Nasopharyngeal cancer Diseases 0.000 title claims abstract description 12
- 201000011216 nasopharynx carcinoma Diseases 0.000 title claims abstract description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 9
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 9
- 239000001301 oxygen Substances 0.000 title claims abstract description 9
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 117
- 238000004088 simulation Methods 0.000 claims description 21
- 238000009825 accumulation Methods 0.000 claims description 17
- 238000005259 measurement Methods 0.000 claims description 7
- 230000007423 decrease Effects 0.000 claims description 6
- 238000004364 calculation method Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 230000000771 oncological effect Effects 0.000 claims description 3
- 239000002245 particle Substances 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 2
- 201000011510 cancer Diseases 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 230000011218 segmentation Effects 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/02—Measuring arrangements characterised by the use of optical techniques for measuring length, width or thickness
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30096—Tumor; Lesion
Abstract
The invention discloses a kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma, including using multi-view stereo vision to carry out three-dimensional reconstruction to tumor, the present invention provides influences that is a kind of high-efficient while considering tumour gradation, tumour particle shape, the compactness for capableing of whole compactness and each grade to tumour calculates, and calculated result can optimize for tumour mixture provide technical support.And the used tumor model of the invention, the tumour partial size of each grade is identical as its actual value, rather than the average value of entire grade tumour partial size, more representative of actual state.
Description
Technical field
The present invention relates to lesion detection fields, more particularly, to a kind of weary oxygen microenvironment image group research model of nasopharyngeal carcinoma
Method for building up.
Background technique
Nasopharyngeal carcinoma refers to the malignant tumour betided at the top of nasopharyngeal cavity with side wall.It is one of high-incidence malignant tumour in China, hair
Sick rate is first of ear,nose & throat malignant tumour.Common symptoms are nasal obstruction, band blood, ear muffle block up sense, Hearing, again in tears
Depending on and headache etc..Nasopharyngeal carcinoma radiotherapy multipair greatly has Medium sensitivity, and radiotherapy is the preferred treatment side of nasopharyngeal carcinoma
Method.But to compared with well-differentiated carcinoma, the course of disease is later and the case of recurrence after radiotherapy, and operation excision and chemotherapy are also fallen within
In indispensable means.
At present in the weary oxygen microenvironment image group research model creation of nasopharyngeal carcinoma, the tumour ginseng of same grade is commonly assumed that
Number is identical, and ignoring between the tumour of same grade still has greatest differences；Existing method only to tumour entirety compactness into
It has gone and has detected or calculated, and the compactness of the tumour of each grade of tumour has not been detected.
Summary of the invention
The present invention is to overcome above situation insufficient, it is desirable to provide a kind of technical solution that can solve the above problem.
A kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma, specifically includes the following steps:
S1, three-dimensional reconstruction is carried out to tumor using multi-view stereo vision；
S2, tumour geological information is extracted, to the oncologic reconstructive model extraction tumour geological information obtained in step S1, including
Long L, width W, the thickness H, volume V of tumor；For any tumour, plane P of the use one perpendicular to tumour long axisi, according to
0.01mm is step pitch, gradually cutting tumor model, reference section PiUpper cloud coordinate xi min、xi max, zi max、zi min, PiAt plane
Wide Wi=xi maxxi min, Hi=zi maxzi min；For all plane P, W is takeni、HiWide W, thickness H of the maximum value as tumour；It is right
In length of tumor L, tumor model is gradually cut according to the step pitch of 0.01mm using the plane perpendicular to tumour axis；Tumour
Length L calculates the calculating referring to wide W, thickness H；For gross tumor volume V, built-in method is calculated in used image procossing library
It arrives；
S3, tumor classification, storage calculate the affiliated grade d of tumor according to tumour 3 D size, calculate sphericity
S；For tumour i, a length of L of tumouri, width Wi, thickness Hi, sphericity SiCalculation is as follows:
The tumour geological information, sphericity are stored in the corresponding set G of grade ddIn.Finally by all GdIt merges into total
Set G.
S4, tumour accumulation simulation calculate.
As a further solution of the present invention: tumour accumulation simulation calculate the following steps are included:
A1, first creation accumulation simulation container；It is assumed that accumulation container volume V, each gross tumor volume of tumour is Vi, then heaping die
Quasi- the ratio between container volume and tumor sample stacking volume n sees below formula:
A2, equivalent sphere set G is generatedeq, use the set G of the set G or some grade d that obtain in step S3d, generate
The set G of equivalent sphereeq；When calculating the compactness of tumour entirety, using tumour unitary set G, some grade of tumour d is calculated
Compactness when, use set Gd；Equivalent sphere is calculated according to the equivalent principle of volume；It is assumed that some gross tumor volume is Vi, then
The equivalent sphere volume of the tumour is Vi, sphericity Si, equivalent redius Ri, overlap coefficient isIt will carry out first
Accumulate the G or G of simulationdEach tumour be converted into equivalent sphere, by the radius of equivalent sphere, volume, sphericity be stored in set G '
In.N+3 times of G ' duplication is generated into equivalent sphere set G according to the n acquired in A1eq；Wherein
A3, sphere B is randomly selectedi, radius Ri, volume Vi, sphericity Si；
A4, random generate place coordinate (xi, yi, zi), wherein Ri≤xi≤ 150, Ri≤yi≤ 150, Ri≤zi≤150；
A5, judge sphere BiIt is placed in (xi, yi, zi) at, item is overlapped with whether the sphere for having placed completion all meets
Part, coincidence condition enter following formula:
If A6, sphere meet BiMeet coincidence condition, then sphere Bi is placed in (xi, yi, zi), its data is stored in and is collected
Close Gp, A7 is entered step, if not satisfied, then skipping to step A8；
A7, judge whether that reaching accumulation simulation stop condition enters step A9 if reaching stop condition, if not satisfied, then
Skip to step A3；
A8, judge equivalent sphere BiWhether skip condition is reached；Here the condition being arranged is to attempt to place 2000 times；If
The coordinate of 2000 generations is not able to satisfy placement demand, then skips the sphere and jump into step A3, skip item if not reaching
Part then jumps into step A4；
A9, tumour decline；For GpIn all spheres carry out whereabouts simulation；An empty sphere set is first generated first
G′p, give GpIn sphere BiOne downwardly direction, when its be in contact with container bottom or with G 'pIn any sphere reach and connect
When touch article part, which stops decline, and the sphere current location and sphere data are stored in set G 'pIn；To GpIn it is all
Sphere successively carries out, and generates new sphere set G 'p；Contact conditions at this time are shown below:
A10, creation measurement container, volume of a container V, the volume V of each sphere in containeri, for being put down by Z=100mm
The sphere of face segmentation, is located at Z=100mm volume V ' belowiCalculating formula is as follows, wherein HiFor sphere be located at Z=100mm with
On height, RiFor radius of sphericity；Calculate the sum of the sphere volume in measurement container Vsum, wherein for by Z=100mm plane
The sphere of segmentation, volume Vi are taken as Vi。
Vsum=∑ Vi；
Then compactness γ=Vsum/V。
Beneficial effects of the present invention: the present invention provides it is a kind of it is high-efficient, consider tumour gradation, tumour particle shape simultaneously
It influences, the compactness for capableing of whole compactness and each grade to tumour calculates, and calculated result can be tumour mixture
Optimization provides technical support.And the used tumor model of the invention, the tumour partial size and its actual value of each grade
It is identical, rather than the average value of entire grade tumour partial size, more representative of actual state.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Specific embodiment
In the embodiment of the present invention, a kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma is specifically included
Following steps:
S1, three-dimensional reconstruction is carried out to tumor using multi-view stereo vision；
S2, tumour geological information is extracted, to the oncologic reconstructive model extraction tumour geological information obtained in step S1, including
Long L, width W, the thickness H, volume V of tumor；For any tumour, plane P of the use one perpendicular to tumour long axisi, according to
0.01mm is step pitch, gradually cutting tumor model, reference section PiUpper cloud coordinate xi min、xi max, zi max、zi min, PiAt plane
Wide Wi=xi max-xi min, Hi=zi max-zi min；For all plane P, W is takeni、HiWide W, thickness H of the maximum value as tumour；
For length of tumor L, tumor model is gradually cut according to the step pitch of 0.01mm using the plane perpendicular to tumour axis；It is swollen
Tumor length L calculates the calculating referring to wide W, thickness H；For gross tumor volume V, built-in method is calculated in used image procossing library
It obtains；
S3, tumor classification, storage calculate the affiliated grade d of tumor according to tumour 3 D size, calculate sphericity
S；For tumour i, a length of L of tumouri, width Wi, thickness Hi, sphericity SiCalculation is as follows:
The tumour geological information, sphericity are stored in the corresponding set G of grade ddIn.Finally by all GdIt merges into total
Set G.
S4, tumour accumulation simulation
4.1 related hypothesis
According to the equal principle of volume, each tumour is equivalent to ball, while in order to consider between particle shape, tumour mutually
The influence of effect allows to have a degree of coincidence between each ball, requires to meet such as between any two ball here
Lower relationship:
It is assumed that 1 radius of ball is r1, coordinate is (x1, y1, z1), 2 radius of ball is r2, coordinate is (x2, y2, z2), two circles
Ball circle center distance should meet following formula:
4.2 accumulation simulation calculation process
The following steps are included:
A1, first creation accumulation simulation container, what we created here is 150mm × 150mm × 150mm cuboid,
Its volume is 3375000mm3；Calculate accumulation simulation the ratio between container volume and tumor sample stacking volume, it is assumed that accumulation container body
Product V, each gross tumor volume of tumour are Vi, then accumulate simulation the ratio between container volume and tumor sample stacking volume n and see below formula.Wherein
2700,1500 be respectively tumour apparent density and bulk density estimated value, general thick tumour apparent density 2600~
2800kg/m3, bulk density is in 1400~1600kg/m3.Here taking apparent density is 2700, and bulk density 1500 is used for
Estimate the stacking volume of tumour.Ensure that sufficient tumour filling container is further added by 3 here on the basis of n
Times, i.e. n=n+3.
N=n+3；
A2, equivalent sphere set G is generatedeq, use the set G of the set G or some grade d that obtain in Section 3d, generate
The set G of equivalent sphereeq.When calculating the compactness of tumour entirety, using tumour unitary set G, some grade of tumour d is calculated
Compactness when, use set Gd.Equivalent sphere is calculated according to the equivalent principle of volume.It is assumed that some gross tumor volume is Vi, then
The equivalent sphere volume of the tumour is Vi, sphericity Si, equivalent redius Ri, overlap coefficient isIt will carry out first
Accumulate the G or G of simulationdEach tumour be converted into equivalent sphere, by the radius of equivalent sphere, volume, sphericity be stored in set G '
In.N+3 times of G ' duplication is generated into equivalent sphere set G according to the n acquired in A1eq。
A3, sphere B is randomly selectedi, radius Ri, volume Vi, sphericity Si。
A4, random generate place coordinate (xi, yi, zi), wherein Ri≤xi≤ 150, Ri≤yi≤ 150, Ri≤zi≤150。
A5, judge sphere BiIt is placed in (xi, yi, zi) at, item is overlapped with whether the sphere for having placed completion all meets
Part, referring to 4.1.
If A6, sphere meet BiMeet coincidence condition, then by sphere BiIt is placed in (xi, yi, zi), its data is stored in and is gathered
Gp enters step A7, if not satisfied, then skipping to step A8.
A7, judge whether that reaching accumulation simulation stop condition enters step A9 if reaching stop condition, if not satisfied, then
Skip to step A3.
A8, judge equivalent sphere BiWhether skip condition is reached.Here the condition being arranged is to attempt to place 2000 times.If
The coordinate of 2000 generations is not able to satisfy placement demand, then skips the sphere and jump into step A3, skip item if not reaching
Part then jumps into step A4.
A9, tumour decline.For GpIn all spheres carry out whereabouts simulation.An empty sphere set is first generated first
G′p, give GpIn sphere BiOne downwardly direction, when its be in contact with container bottom or with G 'pIn any sphere reach and connect
When touch article part, which stops decline, and the sphere current location and sphere data are stored in set G 'pIn.To GpIn it is all
Sphere successively carries out, and generates new sphere set G 'p.Contact conditions at this time are as follows, and wherein 1 coordinate of sphere is (x1,
y1, z1), sphericity S1, 2 coordinate of sphere is (x2, y2, z2), sphericity S2:
A10, creation measurement container, the measurement container created here is 150mm × 150mm × 100mm rectangle, container
Volume V, the volume V of each sphere in containeri, for the sphere divided by Z=100mm plane, it is located at Z=100mm or less
Volume V 'iCalculating formula is as follows, wherein HiIt is located at the height of Z=100mm or more, R for sphereiFor radius of sphericity.Calculate measurement
The sum of sphere volume in container Vsum, wherein volume Vi is taken as V ' for the sphere divided by Z=100mm planei。
Vsum=∑ Vi；
Then compactness γ=Vsum/V；
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, nothing
By from the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by institute
Attached claim rather than above description limit, it is intended that will fall within the meaning and scope of the equivalent elements of the claims
All changes be included within the present invention.
Claims (2)
1. a kind of weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma, which is characterized in that specifically include following step
It is rapid:
S1, three-dimensional reconstruction is carried out to tumor using multi-view stereo vision；
S2, tumour geological information is extracted, to the oncologic reconstructive model extraction tumour geological information obtained in step S1, including tumour
Long L, width W, the thickness H, volume V of tumour；For any tumour, plane P of the use one perpendicular to tumour long axisi, according to 0.01mm
For step pitch, gradually cutting tumor model, reference section PiUpper cloud coordinate xi min、xi max, zi max、zi min, PiWide W at planei
=xi max-xi min, Hi=zi max-zi min；For all plane P, W is takeni、HiWide W, thickness H of the maximum value as tumour；For swollen
Tumor length L gradually cuts tumor model according to the step pitch of 0.01mm using the plane perpendicular to tumour axis；Length of tumor L
Calculate the calculating referring to wide W, thickness H；For gross tumor volume V, built-in method is calculated in used image procossing library；
S3, tumor classification, storage calculate the affiliated grade d of tumor according to tumour 3 D size, calculate sphericity S；It is right
In tumour i, a length of L of tumouri, width Wi, thickness Hi, sphericity SiCalculation is as follows:
The tumour geological information, sphericity are stored in the corresponding set G of grade ddIn.Finally by all GdMerge into total collection
Close G.
S4, tumour accumulation simulation calculate.
2. the weary oxygen microenvironment image group research model method for building up of nasopharyngeal carcinoma according to claim 1, which is characterized in that
Tumour accumulation simulation calculate the following steps are included:
A1, first creation accumulation simulation container；It is assumed that accumulation container volume V, each gross tumor volume of tumour is Vi, then accumulate simulation and hold
Body is long-pending to see below formula with the ratio between tumor sample stacking volume n:
A2, equivalent sphere set G is generatedeq, use the set G of the set G or some grade d that obtain in step S3d, generate equivalent
The set G of balleq；When calculating the compactness of tumour entirety, using tumour unitary set G, the closely knit of some grade of tumour d is calculated
When spending, set G is usedd；Equivalent sphere is calculated according to the equivalent principle of volume；It is assumed that some gross tumor volume is Vi, then the tumour
Equivalent sphere volume is Vi, sphericity Si, equivalent redius Ri, overlap coefficient isAccumulation simulation will be carried out first
G or GdEach tumour be converted into equivalent sphere, will the radius of equivalent sphere, volume, sphericity deposit set G ' in；According in A1
N+3 times of G ' duplication is generated equivalent sphere set G by the n acquiredeq；Wherein
A3, sphere B is randomly selectedi, radius Ri, volume Vi, sphericity Si；
A4, random generate place coordinate (xi,yi,zi), wherein Ri≤xi≤ 150, Ri≤yi≤ 150, Ri≤zi≤150；
A5, judge sphere BiIt is placed in (xi,yi,zi) at, whether all meet the condition of coincidence with the sphere for having placed completion, is overlapped
Condition enters following formula:
If A6, sphere meet BiMeet coincidence condition, then by sphere BiIt is placed in (xi,yi,zi), its data is stored in set Gp,
A7 is entered step, if not satisfied, then skipping to step A8；
A7, judge whether that reaching accumulation simulation stop condition enters step A9 if reaching stop condition, if not satisfied, then skipping to
Step A3；
A8, judge equivalent sphere BiWhether skip condition is reached；Here the condition being arranged is to attempt to place 2000 times；If 2000 times
The coordinate of generation is not able to satisfy placement demand, then skips the sphere and jump into step A3, if not reaching skip condition, jump into
Step A4；
A9, tumour decline；For GpIn all spheres carry out whereabouts simulation；An empty sphere set G ' is first generated firstp,
To GpIn sphere BiOne downwardly direction, when its be in contact with container bottom or with G 'pIn any sphere reach contact conditions
When, which stops decline, and the sphere current location and sphere data are stored in set G 'pIn；To GpIn all spheres successively
It carries out, generates new sphere set G 'p；Contact conditions at this time are shown below:
A10, creation measurement container, volume of a container V, the volume V of each sphere in containeri, for being divided by Z=100mm plane
Sphere, be located at Z=100mm volume V belowi' calculating formula is as follows, wherein HiIt is located at the height of Z=100mm or more for sphere
Degree, RiFor radius of sphericity；Calculate the sum of the sphere volume in measurement container Vsum, wherein for being divided by Z=100mm plane
Sphere, volume Vi are taken as Vi′。
Vsum=∑ Vi；
Then compactness γ=Vsum/V。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547767A (en) * | 2019-08-29 | 2019-12-10 | 暨南大学 | hypoxic imaging strategy for nasopharyngeal carcinoma in-situ and spontaneous metastasis model by taking CAIX as target point |
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| CN107507195A (en) * | 2017-08-14 | 2017-12-22 | 四川大学 | The multi-modal nasopharyngeal carcinoma image partition methods of PET CT based on hypergraph model |
| CN109541186A (en) * | 2018-11-29 | 2019-03-29 | 烟台大学 | A kind of coarse aggregate compactness calculation method based on form parameter |
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| JPH07236634A (en) * | 1994-02-28 | 1995-09-12 | Toshiba Medical Eng Co Ltd | Diagnosis supporting device |
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