CN109621463A - A kind of preparation of cough-relieving tablet evaporation equipment and cough stopping tablet agent producing process - Google Patents
A kind of preparation of cough-relieving tablet evaporation equipment and cough stopping tablet agent producing process Download PDFInfo
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- CN109621463A CN109621463A CN201811586386.3A CN201811586386A CN109621463A CN 109621463 A CN109621463 A CN 109621463A CN 201811586386 A CN201811586386 A CN 201811586386A CN 109621463 A CN109621463 A CN 109621463A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0082—Regulation; Control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/30—Accessories for evaporators ; Constructional details thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of cough-relieving tablet preparation evaporation equipment and cough stopping tablet agent producing process；The production technology of the cough-relieving tablet is the following steps are included: solvent extraction, evaporation and concentration, film-making；Compared with prior art, evaporation equipment, which has, is concentrated by evaporation the functions such as end point determination and integrated control operation, simple in production process operation, and low in cost, meets demand of the modernization industry batch production to automation.
Description
Technical field
The present invention relates to pharmaceutical production fields, and in particular to a kind of preparation of cough-relieving tablet evaporation equipment and the life of cough-relieving tablet
Production. art.
Background technique
The cough-relieving tablet is Chinese medicine resolving sputum agent, has the effect of clearing lung and eliminating the phlegm, relieving cough and asthma.For caused by affection of exogenous wind-cold
It coughs, abundant expectoration is thin, cough is even breathed heavily；Its clinical application has a nearly one-hundred-year history so far, because its effect is magical, produce effects mind
Speed is known as " the anti-consumptive disease panacea " of " meeting cough that must stop ".
In the prior art, the extracting method of most of medium-height grass the effective elements of the medicines generally uses decocting method or extraction.It decocts
Cooking method, refers to add water to cook medicinal material and takes juice；But when being decocted with water, the comparison of ingredients of leaching is complicated, in addition to effective component, part
Liposoluble substance and other impurities also have more leaching, are unfavorable for refining；The ingredients such as furthermore starch-containing, mucilaginous substance, sugar are more
Medicinal material, after adding water to cook, leaching is also more sticky, filters more difficult.Extraction is also referred to as Solid extraction column method, is had with volatility
Certain ingredients in raw material are transferred in solvent phase by solvent, then recycle organic solvent by means such as evaporation, distillations, and
Obtain required more pure extracted component.It is concentrated by evaporation after solvent recovery and drying, what is frequently resulted in is pasty masses,
Referred to as medicinal extract.
Evaporator is usually used in alcohol extracting method or alcohol recycle tank recycles ethyl alcohol.In removal process, with
The evaporation of solvent, that is, ethyl alcohol is recycled, and solute, that is, traditional Chinese medicine ingredients concentration constantly increases in extracting solution, so that the density of liquid is continuous
Increase, thus in process of production usually using density, relative density or specific gravity as evaporation and concentration End point indication index.
In the actual production process, the density, relative density of liquid or specific gravity generally use bottle method or Webster ratio
Weight scale measurement, but both methods requires to be sampled test sample to laboratory, at a certain temperature accurate measurement.But
It is that both methods is complicated for operation and need to carry out accurate calculating etc., it can not directing terminal in time, it is possible to cause to be concentrated
Excessively, lead to energy waste while influencing subsequent transfer, drying, do not meet in industrial production and evaporated in large-scale production
The demand of striking point detection and automation.
In addition, in the prior art also by technological means such as membrane pressure, resonance or ultrasonic waves according to certain with fluid density
The online measuring density instrument of parameter setting for changing and changing can carry out real-time accurate survey to liquid in production process
Amount.But these instruments are very accurate, it is expensive, need particularly to safeguard etc..
Summary of the invention
For the above the deficiencies in the prior art, the invention discloses a kind of cough-relieving tablet preparation evaporation equipments.
A kind of cough-relieving tablet preparation evaporation equipment, including evaporator ontology, the evaporator ontology include a vaporization chamber,
One jacket type heating device, a density monitoring device and a control device；The vaporization chamber is provided with one and external condensation pipe
The evaporation mouth of connection, a feed pipe and a discharge nozzle are provided with a discharge valve at the discharge nozzle；The jacket type heating
Device is sheathed on outside the vaporization chamber, is provided with heat source import and thermal source outlet, is provided with heat source at the heat source import
Imported valve；The density monitoring device is connected to by pipeline with the vaporization chamber；The density monitoring device is in vaporization chamber
Liquid, which is detected and will test signal, is transferred to the control device；The control device will test signal and preset threshold into
Row comparison, when detect signal be greater than preset threshold when, the control device can control the jacket type heater into
Mouth valve is closed, and heating is stopped, and controls discharging tube valve opening, discharging.
Specifically, the density monitoring device includes that a test chamber, two metering pumps and a capacitive films pressure pass
Sensor；The metering pump includes a feed pump and a mateiral pump；The metering pump passes through pipeline connecting detection chamber and evaporation
Tank, wherein the mateiral pump is located at test chamber bottom；The diaphragm pressure sensor is set to the test chamber bottom；The meter
Amount pump and capacitive films pressure sensor are electrically connected with the control device, and the control device periodically controls the metering
Pump successively works, and feed pump draws liquid into test chamber, and the pressure sensor detects it, and mateiral pump is by liquid from chamber
Interior extraction, returns to evaporator；The control device is connected with the pressure sensor；The pressure sensor will test
The data obtained are transferred to the control device, and the signal that the control device will test is compared with preset threshold, works as letter
When number being greater than preset threshold, control device control jacket type heater imported valve is closed, and stops heating, and control
Produce expects pipe valve opening, discharging.
Compared with the existing technology, evaporation equipment provided by the present invention is by being utilized two metering pumps to liquid in evaporating
Time quantitative sampling at equal intervals is carried out, and liquid is measured by capacitive films pressure sensor, when acquired liquid
It is more than the deformation of preset threshold that weight, which issues film, i.e., capacitor generates when being more than the change of preset threshold, i.e. evaporator
Interior fluid density reaches requirement, reaches and is concentrated by evaporation terminal.The present invention is by using two pumps and capacitive films pressure sensing
The combination of device had both met evaporation process and endpoint in Chinese medicine extract industrial batch production process and had supervised to fluid density
The requirement of survey, cost is relatively low, and easy to operate, can satisfy requirement of the modern medicines industrial production to automation.
Further, the control device is default there are two threshold value, and the first threshold is greater than second threshold；When detection is believed
When number being greater than second threshold, the control device controls the density monitoring device and shortens detection cycle；When detection signal is greater than
When first threshold, the control device control jacket type heater imported valve is closed, and stops heating, and control discharging
Tube valve is opened, discharging, is made it possible to adjust sample interval according to actual demand, be facilitated energy saving.
Further, the test chamber is additionally provided with a stomata communicated with the outside world, and test chamber is communicated with the atmosphere, to flat
Air pressure in the test chamber that weighs, avoids it from impacting detection.
Further, a heat-exchange device is arranged in the test chamber, the heat-exchange device is provided with medium disengaging
Mouthful, the entrance is provided with a valve, to carry out temperature control to testing liquid, to avoid inspection of the temperature to liquid
Survey has an impact.
Further, the metering pump is pneumatic diaphragm pump, has the function of self-priming, can be highly-safe with dry running,
It is small in size, light-weight.
Further comprising have multiple density monitoring devices, in parallel with the control device respectively, multiple detection devices
Interval successively works, and can reduce time of measuring, improves End point indication timeliness.
Further, the control device is specially PLC (Programmable Logic Controller) control dress
It sets, i.e. programmable logic controller (PLC), is the electronic device for aiming at a kind of digital operation of industrial production design, it uses one
Class programmable memory is used for its internally stored program, executes logical operation, sequential control, timing, counting and arithmetical operation
Various types of mechanical or production processes are controlled etc. user oriented instruction, and by number or analog pattern input/output.
Aiming at the shortcomings in the prior art, the present invention also provides a kind of preparation processes of cough-relieving tablet.
A kind of preparation process of cough-relieving tablet, is evaporated concentration using evaporation equipment described above, its step are as follows:
(1) preparation of I extract powder: weighing the pappy shell of required parts by weight, according to the solid-liquid ratio of 1:3~1:6, uses body
Than being that 60%~80% alcohol reflux extracts 2 times, each 4h, combined extract is transferred to the evaporation equipment and is concentrated by evaporation back product
It is dried in vacuo and crushes stage by stage after receiving solvent, obtain No. I medicinal extract comminuted powder；
(2) the Exocarpium Citri Rubrum coarse powder, campanulaceae coarse powder, Fructus Aurantii coarse powder, the tuber of stemona of required parts by weight the preparation of II extract powder: are weighed
Coarse powder, Schisandra chinensis coarse powder, dried orange peel coarse powder, rhizoma zingiberis coarse powder, schizonepeta coarse powder, root of purple-flowered peucedanum coarse powder, according to the solid-liquid ratio body of 1:8~1:10
Product is than being to extract 2 times at 60 ± 5 DEG C of 60%~80% ethyl alcohol, each 48h, combined extract, is transferred to the evaporation equipment evaporation
Concentration and recovery solvent obtains II extractum A；
The net medicinal material of aster, Radix Glycyrrhizae for weighing required parts by weight, is placed in multi-function extractor, with the boiling of 8 times of weight
Boiling is extracted 2 times, each 2h, combined extract, is transferred to the evaporation equipment evaporation and concentration recycling design and is obtained II medicinal extract B；
The II extractum A is dried in vacuo and is crushed stage by stage after mixing with II medicinal extract B, II extract powder is obtained
Flour；
(3) it the preparation of tablet: is made after the I medicinal extract comminuted powder, II cream comminuted powder, ammonium chloride are mixed with auxiliary material
Grain is added tabletting after peppermint oil dementholized and 15~20min of lubricant total mix, is coated to obtain the cough-relieving tablet.
Detailed description of the invention
Fig. 1 is evaporation equipment structural schematic diagram of the present invention；
Fig. 2 is density monitoring device structural schematic diagram of the present invention；
Fig. 3 is that evaporation equipment of the present invention carries out liquid flow direction schematic diagram when detection work；
Fig. 4 is control device workflow block diagram of the present invention.
Specific embodiment
Embodiment 1
Referring to Fig. 1 and Fig. 2, Fig. 1 is evaporation equipment structural schematic diagram of the present invention, and Fig. 2 is of the present invention
Density monitoring device structural schematic diagram.
Evaporation equipment used in a kind of preparation of cough-relieving tablet, including evaporator ontology 1.The evaporator ontology 1 wraps
Include a vaporization chamber 10, a jacket type heating device 20, a density monitoring device 30 and a control device (not shown).
The vaporization chamber 10 includes evaporation mouth 12, a feed pipe 14 and the discharge nozzle connecting with external condensation pipe
16；The evaporation mouth 12 is located at 10 top of vaporation-type, and a material inlet valve 142, the discharge nozzle position are provided on the feed pipe
In vaporization chamber bottom, it is provided with a discharging tube valve 162.
The jacket type heating device 20 is sheathed on outside the vaporization chamber 10, and upper part is equipped with heat source import 22, its underpart
It is provided with thermal source outlet 24, heat is carried out with liquid in vaporization chamber 10 by 10 outer wall of vaporization chamber using heat source and exchanges, evaporate back
Receive solvent；The heat source import 22 and outlet 24 are respectively arranged with imported valve 222 and outlet valve 242, with flow control
Function processed enters the flow of jacket type heating device 20 to control heat source, and then controls the progress of heating and stop and control
Make the speed of heating.
The density monitoring device 30 is set to the evaporator body exterior, is connected by pipeline and the vaporization chamber 10
It is logical, enable liquid in the vaporization chamber 10 to enter the density monitoring device 30 by pipeline and detected.It is described close
Spending monitoring device 30 includes that 31, two metering pumps 32 (feed pump 322 and mateiral pump 324) of a test chamber and a condenser type are thin
Membrane pressure sensor 33.The test chamber 31 is a hollow cylindrical, and top is provided with a stomata 35 communicated with the outside world, makes
Test chamber 31 is communicated with the atmosphere, and to air pressure in balance detection chamber 31, draught head is avoided to have an impact detection.The metering pump
32 include feed pump 322 and mateiral pump 324, and specifically, two metering pumps are pneumatic diaphragm pump, is connected and is examined by pipeline
Chamber 31 and vaporization chamber 10 are surveyed, wherein feed pump 322 is located at 31 top of test chamber, and mateiral pump 324 is located at 31 bottom of test chamber.It is described
Diaphragm pressure sensor 33 is set to 31 bottom of test chamber, and film side is in contact with prepare liquid.Since temperature is to liquid
The detection of volume density has a degree of influence, in order to reduce the error as caused by temperature in repeated detection, the inspection
It surveys outside chamber 31 and is also arranged with a heat-exchange device 34, be provided with medium entrance 342 and media outlet 344, medium includes cold source
And heat source；It is provided with a three-way valve 346 at the medium entrance, is connected respectively with cold source and heat source.Cold source, i.e. constant temperature are cold
But water constantly flows in heat-exchange device, so that testing liquid maintains and same temperature, reduces measurement error.In addition, temperature
After reduction, contain organic substance and be possible to as the liquid of solute because cooling and viscosity becomes larger, thus can in test chamber 31
Wall sticks together, and causes mateiral pump 324 that can not pump out its whole, influences subsequent measurement, using heat source, hot water is constantly in heat
Flowing in switch facilitates mateiral pump 324 and is pumped out, avoid making subsequent measurement to heat to prepare liquid
At influence.A temperature sensor (not shown) is additionally provided in the heat-exchange device 34, the temperature sensor is to test chamber
Interior liquid is detected, and will test data transmission to the control device.
The control device is specially PLC control device, controls the 20 heat source import valve of jacket type heating device
242, the folding of medium entrance valve described in 30 heat-exchange device of density monitoring device.The control device, which receives, comes from institute
The signal that diaphragm pressure sensor and the temperature sensor transmit is stated, and analyzes it judgement, controls the density
The work of monitoring device metering pump and diaphragm pressure sensor 33.
When work, liquid to be evaporated enters vaporization chamber 10 by liquid feed pipe 14, and the control device controls collet
10 heat source import valve 242 of formula heating device is passed through heat source, carries out heat exchange with liquid in vaporization chamber 10, evaporates solvent；It is described
Control device periodically controls the density monitoring device 30 and is sampled detection to liquid in vaporization chamber 10.Referring to figure 3., scheme
3 carry out liquid flow direction schematic diagram when detection work for evaporation equipment of the present invention.As shown, specifically, it is described into
Quantitative testing liquid 322 is pumped into the test chamber 31 by material pump, at the same the control device control heat-exchange device medium into
Mouth valve is opened, and is passed through cooling water and is cooled down to testing liquid；Temperature sensor described in cooling procedure carries out temperature to it
Detection, when temperature reaches preset value, the capacitive films pressure sensor 33 detects it and sends data to institute
State control device.After the completion of detection, the heat-exchange device medium entrance valve is passed through hot water, heats to testing liquid,
When temperature reaches preset value, the mateiral pump 324 will test intracavity liquid pump and walk, and back in vaporization chamber along pipeline.
The density monitoring device detect and can compare by preset threshold to fluid density reaching terminal
The purpose of detection, principle are as follows: in removal process, as the evaporation of solvent, that is, alcohol is recycled, solute, that is, Chinese medicine in extracting solution
The concentration of ingredient constantly increases, so that the density of liquid constantly increases.The density monitoring device utilizes metering pump periodicity work
The liquid of equal volume amounts is pumped into work every time, when the density of liquid constantly increases, the weight of the liquid of equal volume amounts constantly increases
Greatly, the deformational displacement value that the film of the capacitive films sensor occurs equally constantly increases, so that sensor is electric
Appearance changes.The corresponding capacitor of shift value that film occurs for the density of liquid is thus corresponded to by default evaporation terminal
Value, the control device compare the capacitor of the sensor with preset threshold, can judge whether evaporate indoor liquid
Reach the requirement of required density, the mesh whether control evaporation operation continues is reached by the entrance of control heat source to reach
, so that reaching the demand of evaporation process automation end point determination in intermittent production.
Referring to figure 4., Fig. 4 is control device workflow block diagram of the present invention.It is built-in fixed that the control device passes through
When functional cycle control the density monitoring device detection, such as sample interval be sampled to the evaporation indoor liquid
For t=5 (min), n-th sample data are denoted as iN(N≥1).The control device is preset with first threshold a and the second threshold
Value b, wherein the first threshold is that fluid density makes the thin film sensor film when material evaporation concentration operation is reached home
Capacitance corresponding to deformation occurs shift value, the second threshold b are less than the first threshold.The control device is to described
The i that sensor transmitsNJudged, as a >=iNWhen >=b, when the control device controls the density monitoring device shortening sampling
Between be spaced, be t=3 (min)；Work as iNWhen >=a, the control device control density monitoring device stops working；The jacket type
20 heat source import valve 222 of heating device is closed, and heating is stopped, and evaporation and concentration is reached home；The discharging tube valve is opened, out
Material.
A kind of cough-relieving tablet prepared using above-mentioned evaporation equipment, the raw material including following parts by weight meter: pappy shell 90
~120 parts, 26~38 parts of aster, 15~26 parts of Exocarpium Citri Rubrum, 15~26 parts of the tuber of stemona, 3~7 parts of Schisandra chinensis, 26~38 parts of campanulaceae, Fructus Aurantii
3~7 parts, 26~38 parts of dried orange peel, 10~22 parts of schizonepeta, 40~54 parts of the root of purple-flowered peucedanum, 3~7 parts of rhizoma zingiberis, 85~105 parts of Radix Glycyrrhizae, ammonium chloride
65~85 parts, 0.3~0.8 part of peppermint oil dementholized, 50~80 parts of mannitol, 130~150 parts of 2% aqueous povidone solution,
40~65 parts of sodium carboxymethyl starch, 25~45 parts of magnesium stearate.
Its preparation process includes the following steps:
(1) preparation of I extract powder: weighing the pappy shell of the parts by weight, according to the solid-liquid ratio of 1:3~1:6, uses body
Product is than being that 60%~80% alcohol reflux extracts 2 times, each 4h, combined extract, true stage by stage after evaporation and concentration recycling ethyl alcohol
Sky is dry and crushes, and obtains No. I medicinal extract comminuted powder；
(2) the Exocarpium Citri Rubrum coarse powder, campanulaceae coarse powder, Fructus Aurantii coarse powder, the tuber of stemona of the parts by weight preparation of II extract powder: are weighed
Coarse powder, Schisandra chinensis coarse powder, dried orange peel coarse powder, rhizoma zingiberis coarse powder, schizonepeta coarse powder, root of purple-flowered peucedanum coarse powder, according to the solid-liquid ratio body of 1:8~1:10
Product is than being to extract 2 times at 60 ± 5 DEG C of 60%~80% ethyl alcohol, each 48h, combined extract, is transferred to the evaporation equipment evaporation
Concentration and recovery solvent is to iNII extractum A is obtained when >=a；
The net medicinal material of aster, Radix Glycyrrhizae for weighing the parts by weight, sets in multi-function extractor, is boiled with the boiling of 8 times of weight
It extracts 2 times, each 2h, combined extract, is transferred to the evaporation equipment and is concentrated by evaporation recycling design and obtain II medicinal extract B to iN >=a；
The II extractum A is dried in vacuo and is crushed stage by stage after mixing with II medicinal extract B, II extract powder is obtained
Flour；
(3) it the preparation of tablet: is made after the I medicinal extract comminuted powder, II cream comminuted powder, ammonium chloride are mixed with auxiliary material
Grain is added tabletting after peppermint oil dementholized and lubricant total mix 15min~20min, is coated to obtain the cough-relieving tablet；
Embodiment 2
In the present embodiment, the preparation process of the cough-relieving tablet is same as Example 1, evaporation concentration equipment and implementation
1 main distinction of example is only that, containing multiple density monitoring devices, is connected in parallel respectively with the control device.The control dress
The multiple density monitoring device interval work of control are set, interval time of measurement can be reduced, so that the accuracy of detection is improved, so that
End point determination is more timely and accurate.
Compared with the existing technology, evaporation concentration equipment and technique of the present invention to the production use of Chinese medicine compound antitussive object
It is improved, by the way that two metering pumps are utilized is carried out to evaporation pot liquid the time at equal intervals in intermittent industrial production
Quantitative sampling measures liquid by the capacitive films pressure sensor built in device, when acquired liquid quality
So that film issues the deformation more than preset threshold, i.e., when capacitor generates the change more than preset threshold, that is, evaporate pot liquid
Density reaches requirement, reaches and is concentrated by evaporation terminal.Evaporation equipment provided by the present invention and technique, have in evaporation process and
To the function of fluid density monitoring when endpoint, cost is relatively low, and easy to operate, can satisfy modern medicines industrial production pair
The requirement of automation control.
The invention is not limited to above embodiment, if not departing from the present invention to various changes or deformation of the invention
Spirit and scope, if these changes and deformation belong within the scope of claim and equivalent technologies of the invention, then this hair
It is bright to be also intended to encompass these changes and deformation.
Claims (9)
1. a kind of cough-relieving tablet preparation evaporation equipment, including evaporator ontology, it is characterised in that: the evaporator ontology includes
One vaporization chamber, a jacket type heating device, a density monitoring device and a control device；The vaporization chamber be provided with one with it is outer
Evaporation mouth, a feed pipe and a discharge nozzle for portion's condenser pipe connection, is provided with a discharge valve at the discharge nozzle；The folder
Jacketing heat device is sheathed on outside the vaporization chamber, is provided with heat source import and thermal source outlet, is set at the heat source import
It is equipped with heat source import valve；The density monitoring device is connected to by pipeline with the vaporization chamber；The density monitoring device pair
Evaporation indoor liquid, which is detected and will test signal, is transferred to the control device；The control device will test signal and pre-
If threshold value compares, when detecting signal greater than preset threshold, the control device can control the jacket type heating dress
The closing of heat source import valve is set, heating is stopped, and controls discharging tube valve and opens, discharging.
2. evaporation equipment according to claim 1, it is characterised in that: the density monitoring device include a test chamber,
Two metering pumps and a capacitive films pressure sensor；The metering pump includes a feed pump and a mateiral pump；The meter
Amount pump is by pipeline connecting detection chamber and vaporization chamber, wherein the mateiral pump is located at test chamber bottom；The diaphragm pressure passes
Sensor is set to the test chamber bottom；The metering pump and capacitive films pressure sensor are electrically connected with the control device
It connects, the control device periodically controls the feed pump and mateiral pump successively works, and feed pump draws liquid into test chamber, institute
It states pressure sensor to detect it, mateiral pump returns to evaporator by liquid from intracavitary extraction after the completion of detection；It is described
Control device is connected with the pressure sensor, and the pressure sensor will test signal and be transferred to the control device, institute
It states control device and will test signal and compared with preset threshold, when signal is greater than preset threshold, the control device control
Jacket type heater imported valve is closed, and heating is stopped, and is controlled discharging tube valve and opened, discharging.
3. evaporation equipment according to claim 2, it is characterised in that: the control device is default, and there are two threshold values, described
First threshold is greater than second threshold；When detecting signal greater than second threshold, the control device controls the measuring density dress
Set shortening detection cycle；When detecting signal and being greater than first threshold, the control device control jacket type heater into
Mouth valve is closed, and heating is stopped, and controls discharging tube valve opening, discharging.
4. evaporation equipment according to claim 2, it is characterised in that: the test chamber is additionally provided with the gas communicated with the outside world
Hole.
5. evaporation equipment according to claim 2, it is characterised in that: a heat-exchange device is arranged in the test chamber,
Its is intracavitary to be provided with a temperature sensor；The heat-exchange device is provided with medium inlet and outlet, and the entrance is provided with a valve
Door.
6. evaporation equipment according to claim 2, it is characterised in that: the metering pump is pneumatic diaphragm pump.
7. evaporation equipment according to claim 2, it is characterised in that: it includes multiple density monitoring devices, respectively with
The control device is in parallel.
8. evaporation equipment according to claim 2, it is characterised in that: the operating device is PLC system.
9. a kind of preparation process of cough-relieving tablet, which is characterized in that using any evaporation equipment of claim 1~8 into
Row is concentrated by evaporation, and its step are as follows:
1) preparation of .I extract powder: weighing the pappy shell of required parts by weight, according to the solid-liquid ratio volume ratio of 1:3~1:6
For 60%~80% alcohol reflux extraction 2 times, each 4h, combined extract is transferred to sublevel after the evaporation equipment recycling design
Section is dried in vacuo and crushes, and obtains No. I medicinal extract comminuted powder；
2) preparation of .II extract powder: Exocarpium Citri Rubrum coarse powder, campanulaceae coarse powder, Fructus Aurantii coarse powder, the tuber of stemona for weighing required parts by weight are thick
Powder, Schisandra chinensis coarse powder, dried orange peel coarse powder, rhizoma zingiberis coarse powder, schizonepeta coarse powder, root of purple-flowered peucedanum coarse powder, according to the solid-liquid ratio volume of 1:8~1:0
Than being to extract 2 times, each 48h at 60 ± 5 DEG C of 60%~80% ethyl alcohol, it is molten to be transferred to the evaporation equipment recycling for combined extract
Agent obtains II extractum A；
The net medicinal material of aster, Radix Glycyrrhizae for weighing required parts by weight, sets in multi-function extractor, extracts 2 with the boiling boiling of 8 times of weight
Secondary, each 2h, combined extract is transferred to the evaporation equipment recycling design and obtains II medicinal extract B；
The II extractum A is dried in vacuo and is crushed stage by stage after mixing with II medicinal extract B, the crushing of II medicinal extract is obtained
Powder；
3) preparation of tablet: after No. I medicinal extract comminuted powder, cough-relieving tablet II cream comminuted powder, ammonium chloride are mixed with auxiliary material
Granulation is added tabletting after peppermint oil dementholized and 15~20min of lubricant total mix, is coated to obtain the cough-relieving tablet.
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| CN117109812A (en) * | 2023-10-23 | 2023-11-24 | 常州乐研分离技术有限公司 | Structure tightness detection equipment for evaporation drying integrated machine |
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| CN105561275A (en) * | 2016-01-28 | 2016-05-11 | 广东台城制药股份有限公司 | Preparation method of cough-relieving tablet |
| US20170015936A1 (en) * | 2015-01-21 | 2017-01-19 | Lisa F. Kinney | Apparatus and method for extracting organic compounds from plant material using carbon dioxide |
| CN206508595U (en) * | 2017-01-18 | 2017-09-22 | 广东立国制药有限公司 | A kind of intelligent automatic liquid distributing device |
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| US20170015936A1 (en) * | 2015-01-21 | 2017-01-19 | Lisa F. Kinney | Apparatus and method for extracting organic compounds from plant material using carbon dioxide |
| CN105561275A (en) * | 2016-01-28 | 2016-05-11 | 广东台城制药股份有限公司 | Preparation method of cough-relieving tablet |
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| CN110357818A (en) * | 2019-06-25 | 2019-10-22 | 湖南正清制药集团股份有限公司 | A kind of concentration detection method and device for the extraction cucoline in caulis sinomenii |
| CN117109812A (en) * | 2023-10-23 | 2023-11-24 | 常州乐研分离技术有限公司 | Structure tightness detection equipment for evaporation drying integrated machine |
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