CN109620870A - Chinese medicine composition for treating treating rheumatic ostealgia and preparation method thereof and purposes - Google Patents

Chinese medicine composition for treating treating rheumatic ostealgia and preparation method thereof and purposes Download PDF

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CN109620870A
CN109620870A CN201811507185.XA CN201811507185A CN109620870A CN 109620870 A CN109620870 A CN 109620870A CN 201811507185 A CN201811507185 A CN 201811507185A CN 109620870 A CN109620870 A CN 109620870A
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王宏慧
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Abstract

The present invention provides a kind of Chinese medicine composition for treating treating rheumatic ostealgia and preparation method thereof and purposes, it is related to the field of Chinese medicines, which includes the bulk pharmaceutical chemicals of following parts by weight: 8~12 parts of ramulus cinnamomi, 10~14 parts of pawpaw, 4~8 parts of radix achyranthis bidentatae, 12~17 parts of cortex acanthopanacis, 8~12 parts of perilla leaf, 6~10 parts of Radix Angelicae Sinensis and 13~18 parts of Poria cocos.The existing Chinese medicine composition slow effect for for treating treating rheumatic ostealgia can be alleviated using the Chinese medicine composition for being used to treat treating rheumatic ostealgia, the uncertain technical problem of therapeutic effect reaches quick, the good purpose of therapeutic effect.

Description

Chinese medicine composition for treating treating rheumatic ostealgia and preparation method thereof and purposes
Technical field
The present invention relates to the field of Chinese medicines, more particularly, to a kind of Chinese medicine composition for treating treating rheumatic ostealgia and its preparation Method and purposes.
Background technique
Rheumatism bone disease in doctor trained in Western medicine be known as rheumatic fever, rheumatic arthritis, rheumatoid arthritis, protrusion of lumber intervertebral disc, The diseases such as osteoproliferation, using arthralgia, aching and tired, numb, limitation of activity, stiffness and deforming as main clinical manifestation, serious bed It does not rise, is in great pain, can't take care of oneself.Doctors' lore thinks that this disease belongs to the range of " rheumatism ".The factor for inducing this disease is Because of human liver, spleen, kidney asthenia of essence and blood, muscles and bones dystrophy, wind, cold, wet in nature, heat evil intrusion human body make into joint The resistance of qi and blood numbness, causes QI-blood circulation unsmooth, causes blockage of main and collateral channels or the turbid extravasated blood of phlegm or work and rest wound that extravasated blood is caused to stagnate, passages through which vital energy circulates It is obstructed, cause arthralgia, extremity numbness, anchylosis, bend the symptoms such as body is unfavorable.
In current existing technology, this disease of western medical treatment is often irradiated with anti-inflammatory analgetic, hormone, closing, ultraviolet light, is led The methods of draws, performs the operation, it is treatment time length, weak curative effect, expensive the disadvantage is that palliative, and surgical risk is higher, both It is not easy to eradicate, and toxic side effect is big, be easy to cause vicious circle, destroy the human body ecological balance, lead to body's immunity again Imbalance causes this sick obstinate.Thus since, great pain has been brought to patient.
And the Chinese medicine of presently commercially available treatment rheumatism bone disease, slow effect, effect are uncertain, need to generally even served 1-2 months with Upper ability is strong, and patient's Chang Yin Time of Administration length loses the confidence and abandons taking.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention be to provide it is a kind of for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, it is existing to alleviate For the Chinese medicine composition slow effect for treating treating rheumatic ostealgia, the uncertain technical problem of therapeutic effect.
The second object of the present invention is to provide a kind of preparation method of above-mentioned Chinese medicine composition, this method simple process, And it is suitble to industrialized production.
The third object of the present invention is to provide a kind of purposes of above-mentioned Chinese medicine composition, be prepared using the Chinese medicine composition Drug can be used for treating traumatic injury and painful swelling of joints.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
It is a kind of for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, including the mouth being mainly made of the bulk pharmaceutical chemicals of following parts by weight Medication: 8~12 parts of ramulus cinnamomi, 10~14 parts of pawpaw, 4~8 parts of radix achyranthis bidentatae, 12~17 parts of cortex acanthopanacis, 8~12 parts of perilla leaf, Radix Angelicae Sinensis 6~ 10 parts and 13~18 parts of Poria cocos.
Further, the oral medicine includes the bulk pharmaceutical chemicals of following parts by weight: 9~11 parts of ramulus cinnamomi, 11~13 parts of pawpaw, ox 5~7 parts of knee, 13~16 parts of cortex acanthopanacis, 9~11 parts of perilla leaf, 7~9 parts of Radix Angelicae Sinensis and 14~17 parts of Poria cocos.
Further, the oral medicine includes the bulk pharmaceutical chemicals of following parts by weight: 9.5~10.5 parts of ramulus cinnamomi, pawpaw 11.5~ 12.5 parts, 5.5~6.5 parts of radix achyranthis bidentatae, 14~16 parts of cortex acanthopanacis, 9.5~10.5 parts of perilla leaf, 7.5~8.5 parts of Radix Angelicae Sinensis and Poria cocos 15 ~16 parts.
Further, the Chinese medicine composition further includes the medicine for external application being mainly made of the bulk pharmaceutical chemicals of following parts by weight: Qiang 1~3 part living, 0.5~1.5 part of rheum officinale, 0.5~1.5 part of the root of Beijing euphorbia, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of the root of Dahurain angelica and wistlet 3 ~5 parts.
Further, the medicine for external application includes the bulk pharmaceutical chemicals of following parts by weight: the bulk pharmaceutical chemicals including following parts by weight: Qiang 1.5~2.5 parts of work, 0.7~1.3 part of rheum officinale, 0.7~1.3 part of the root of Beijing euphorbia, 0.7~1.3 part of Radix Notoginseng, 0.7~1.3 part of the root of Dahurain angelica and work 3.2~4.5 parts of blood rattan.
Further, the medicine for external application includes the bulk pharmaceutical chemicals of following parts by weight: the bulk pharmaceutical chemicals including following parts by weight: Qiang 1.7~2.2 parts of work, 0.8~1.2 part of rheum officinale, 0.8~1.2 part of the root of Beijing euphorbia, 0.8~1.2 part of Radix Notoginseng, 0.8~1.2 part of the root of Dahurain angelica and work 3.5~4.5 parts of blood rattan.
It is a kind of above-mentioned for treating the preparation method of the Chinese medicine composition for the treatment of rheumatic ostealgia, by ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, slender acanthopanax Skin, perilla leaf, Radix Angelicae Sinensis and Poria cocos obtain the oral medicine after being pulverized and mixed.
A kind of preparation method of above-mentioned Chinese medicine composition, comprising the following steps:
A the oral medicine is obtained after) being pulverized and mixed ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos;
B) wistlet is dipped in 20~50 ° of white wine of 40~60 parts by weight sealed soak 15~20 days, obtains liquid medicine;
C) powder mixture of Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng and the root of Dahurain angelica is mixed and adjusted with the obtained liquid medicine of step B) At medicine for external application paste;
The step A) obtained oral medicine and the step C) obtained medicine for external application forms the Chinese medicine composition.
Further, the step C) in, flour is added in the powder mixture and the liquid medicine, is tuned into after mixing Paste medicine for external application paste.
Purposes of the above-mentioned Chinese medicine composition in preparation treatment traumatic injury and painful swelling of joints drug.
Compared with the prior art, the invention has the following beneficial effects:
Provided by the present invention for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, including mainly by the ramulus cinnamomi of specific proportion, wood The oral medicine of melon, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos composition.In the oral medicine, with pawpaw, radix achyranthis bidentatae and cortex acanthopanacis work Pass through each raw material using ramulus cinnamomi, perilla leaf, Radix Angelicae Sinensis and Poria cocos as promoting the circulation of qi nerve-soothing drug ingredient for the drug ingedient that dysmenorrhea is active Interaction and mutual cooperation between medicine play the role of quick acting for rheumatism bone disease and effectively cure rheumatism bone disease.Especially For chronic rheumatoid osteopathy, therapeutic effect has the advantages that quick and effect is good, using Chinese medicine composition, after 3 days i.e. Skeleton pain can be effectively relieved and bone is ached, can reach within general 1-3 months the purpose of healing.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is The conventional products that can be obtained by commercially available purchase.
On the one hand, the present invention provides a kind of for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, including mainly by following heavy Measure part bulk pharmaceutical chemicals composition oral medicine: 8~12 parts of ramulus cinnamomi, 10~14 parts of pawpaw, 4~8 parts of radix achyranthis bidentatae, 12~17 parts of cortex acanthopanacis, 8~12 parts of perilla leaf, 6~10 parts of Radix Angelicae Sinensis and 13~18 parts of Poria cocos.
Ramulus cinnamomi has very high medical value, mainly contains volatile oil, Coumarins, terpene, lignans constituents. Modern pharmacological research proves, ramulus cinnamomi have antipyretic cooling, calm, analgesia, it is anticonvulsion, expand blood vessel, be anticoagulant, inhibit platelet aggregation, The effects of antipathogen.Such as Ramulus Cinnamomi Volatile oil can inhibit the release of inflammatory mediator histamine and prostaglandin E (PGE), clearly Except excessive free radical (LPO, MDA), to protect myocardial cell membrane and cell not by the damage of oxidation.In addition, ramulus cinnamomi Fibrin ferment can be completely inhibited in vitro promotes fibrinogen to become fibrinous effect, can significantly extend thrombin of beef cohesion Human fibrinogen's time, to show that ramulus cinnamomi has significant blood coagulation resisting function.
Pawpaw, it is warm-natured, sour, enter liver, the spleen channel;Pawpaw can be used for rheumatic arthralgia, muscle arteries and veins contraction, tinea pedis swelling and pain.Pawpaw There is preferable relaxing tendons and activating collaterals to act on, and energy dampness elimination, is commonly used to control rheumatic arthralgia, muscle arteries and veins contraction person's especially key medicine.In addition, pawpaw Can be used for vomiting and diarrhoea spasm, and pawpaw controls this disease, first make it is wet it is turbid must change, it is middle burnt to reconcile;Second relaxing tendons and activating collaterals, make to spit it is sharp excessive and The diseased contraction of the foot of cause is suddenly alleviated.
Radix achyranthis bidentatae has effects that nourishing liver and kidney, strengthening the bones and muscles, blood circulation, ensurings proper downward flow of the blood, inducing diuresis for treating strangurtia.
Cortex acanthopanacis has wind-damp dispelling, tonifies the liver and kidney, and strengthens muscles and bones, the effect of inducing diuresis for removing edema.
Perilla leaf, relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach can solving toxin of fish and crab for anemofrigid cold, cough evil of vomitting, the vomiting of pregnancy.
Radix Angelicae Sinensis is used for blood deficiency chlorosis, and dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia falls and flutter damage Wound, ulcer sores, dry constipation of intestines.
Poria cocos is used for edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Provided by the present invention for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, including mainly by the ramulus cinnamomi of specific proportion, wood The oral medicine of melon, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos composition.In the oral medicine, with pawpaw, radix achyranthis bidentatae and cortex acanthopanacis work Pass through each raw material using ramulus cinnamomi, perilla leaf, Radix Angelicae Sinensis and Poria cocos as promoting the circulation of qi nerve-soothing drug ingredient for the drug ingedient that dysmenorrhea is active Interaction and mutual cooperation between medicine play the role of quick acting for rheumatism bone disease and effectively cure rheumatism bone disease.Especially For chronic rheumatoid osteopathy, therapeutic effect has the advantages that quick and effect is good, using Chinese medicine composition, after 2 days i.e. Skeleton pain can be effectively relieved and bone is ached, can reach within general 1-3 months the purpose of healing.
In addition, Chinese medicine composition provided by the invention, also has therapeutic effect for traumatic injury and painful swelling of joints.For falling It beats for damage and painful swelling of joints, after Chinese medicine composition provided by the invention, is significantly controlled using just having after 1-5 days Therapeutic effect can relieve pain, subsiding swelling and resolving stagnation.
In the present invention, the typical but non-limiting parts by weight of ramulus cinnamomi for example can be 8 parts, 9 parts, 10 parts, 11 parts or 12 Part;The typical but non-limiting parts by weight of pawpaw for example can be 10 parts, 11 parts, 12 parts, 13 parts or 14 parts;Radix achyranthis bidentatae it is typical but Unrestricted parts by weight for example can be 4 parts, 5 parts, 6 parts, 7 parts or 8 parts;The typical but non-limiting parts by weight of cortex acanthopanacis Numerical example such as can be 12 parts, 13 parts, 14 parts, 15 parts, 16 parts or 17 parts;The typical but non-limiting parts by weight of perilla leaf are for example It can be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts;The typical but non-limiting parts by weight of Radix Angelicae Sinensis for example can be 6 parts, 7 parts, 8 Part, 9 parts or 10 parts;The typical but non-limiting parts by weight of Poria cocos for example can for 13 parts, 14 parts, 15 parts, 16 parts, 17 parts or 18 parts.
In certain embodiments of the present invention, the oral medicine includes the bulk pharmaceutical chemicals of following parts by weight: ramulus cinnamomi 9~11 Part, 11~13 parts of pawpaw, 5~7 parts of radix achyranthis bidentatae, 13~16 parts of cortex acanthopanacis, 9~11 parts of perilla leaf, 7~9 parts of Radix Angelicae Sinensis and Poria cocos 14~ 17 parts.In further preferred embodiment of the present invention, the oral medicine includes the bulk pharmaceutical chemicals of following parts by weight: ramulus cinnamomi 9.5 ~10.5 parts, 11.5~12.5 parts of pawpaw, 5.5~6.5 parts of radix achyranthis bidentatae, 14~16 parts of cortex acanthopanacis, 9.5~10.5 parts of perilla leaf, when Return 7.5~8.5 parts and 15~16 parts of Poria cocos.
The proportion between each bulk pharmaceutical chemicals by optimizing the oral medicine, can be further improved the medicine of the Chinese medicine composition Effect.
In certain embodiments of the present invention, the Chinese medicine composition further includes mainly by the bulk pharmaceutical chemicals of following parts by weight The medicine for external application of composition: the Chinese medicine composition further includes the bulk pharmaceutical chemicals of following parts by weight: 1~3 part of Rhizoma Et Radix Notopterygii, rheum officinale 0.5~1.5 Part, 0.5~1.5 part of the root of Beijing euphorbia, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of the root of Dahurain angelica and 3~5 parts of wistlet.
By the way that Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng, the root of Dahurain angelica and wistlet is added, externally used paste can be made, thus in avoiding Medicine is taken, is easy to use, and will not lessen the curative effect.On the contrary, by the way that Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng, the root of Dahurain angelica and wistlet is added After the medicine is changed to externally applied drug, the therapeutic effect to traumatic injury and painful swelling of joints can also be significantly improved.
Rhizoma Et Radix Notopterygii has effects that cold dispelling, wind-dispelling, dehumidifying, analgesic, has a headache for anemofrigid cold, rheumatic arthralgia, shoulder back acid Bitterly.
Rheum officinale, purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow;For real heat constipation, stagnate abdominal pain, and dysentery is not well, damp and hot Huang Subcutaneous ulcer, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, blood stasis closed, traumatic injury control scald outside;Upper digestion Gastrointestinal hemorrhage.
The root of Beijing euphorbia, root are used as medicine, and defaecation of relieving oedema or abdominal distension through diuresis or purgation, dispersing swelling and dissipating binds cure mainly oedema, and have the benefits of promoting menstruation;Also it can be used as veterinary drug, have Poison is preferably used with caution.
Radix Notoginseng, for spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
The root of Dahurain angelica, wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving;For having a headache, having a toothache, nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge, carbuncle Subcutaneous ulcer sore, pruitus.
Wistlet, refreshing and detoxicating Chinese medicine have promoting blood circulation and removing obstruction in channels, beaten stasis, the effect of wind dispelling insecticide;Control acute and chronic door screen Tail is scorching, rheumatic arthralgia, dysentery with bloody stool, blood strangury, irregular menstruation, infantile malnutrition due to digestive disturbances or intestinalparasites, worm pain, injury from falling down.
The combination of above-mentioned several Chinese medicine materials can both remove the toxicity of the root of Beijing euphorbia, and the outer used time can also quickly play relaxing muscles and tendons Active, swelling and pain relieving treats the purpose of traumatic injury.Feeling of pain will mitigate after coating twice, can reduce swelling within 2-5 days.
In the above-described embodiment, the typical but non-limiting parts by weight of Rhizoma Et Radix Notopterygii for example can for 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts;The typical but non-limiting parts by weight of rheum officinale for example can be 0.5 part, 0.7 part, 1 part, 1.2 parts or 1.5 Part;The typical but non-limiting parts by weight in the root of Beijing euphorbia for example can be 0.5 part, 0.7 part, 1 part, 1.2 parts or 1.5 parts;Radix Notoginseng allusion quotation Type but unrestricted parts by weight for example can be 0.5 part, 0.7 part, 1 part, 1.2 parts or 1.5 parts;The root of Dahurain angelica is typical but unrestricted Property parts by weight for example can be 0.5 part, 0.7 part, 1 part, 1.2 parts or 1.5 parts;The typical but non-limiting weight of wistlet Number for example can be 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts.
In further preferred embodiment of the present invention, the medicine for external application includes the bulk pharmaceutical chemicals of following parts by weight: Qiang 1.5~2.5 parts of work, 0.7~1.3 part of rheum officinale, 0.7~1.3 part of the root of Beijing euphorbia, 0.7~1.3 part of Radix Notoginseng, 0.7~1.3 part of the root of Dahurain angelica and work 3.2~4.5 parts of blood rattan.In the embodiment of the present invention still more preferably, the medicine for external application includes following parts by weight Bulk pharmaceutical chemicals: 1.7~2.2 parts of Rhizoma Et Radix Notopterygii, 0.8~1.2 part of rheum officinale, 0.8~1.2 part of the root of Beijing euphorbia, 0.8~1.2 part of Radix Notoginseng, the root of Dahurain angelica 0.8~ 1.2 parts and 3.5~4.5 parts of wistlet.
Second aspect, it is above-mentioned for treating the preparation method of the Chinese medicine composition for the treatment of rheumatic ostealgia that the present invention provides one kind, The oral medicine is obtained after ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos are pulverized and mixed.
Have using the Chinese medicine composition that the preparation method obtains above-mentioned for treating the Chinese medicine composition for the treatment of rheumatic ostealgia All advantages, details are not described herein.
The third aspect, it is above-mentioned for treating the preparation method of the Chinese medicine composition for the treatment of rheumatic ostealgia that the present invention provides one kind, The following steps are included:
A the oral medicine is obtained after) being pulverized and mixed ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos;
B) wistlet is dipped in 20~50 ° of white wine of 40~60 parts by weight sealed soak 15~20 days, obtains liquid medicine;
C) powder mixture of Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng and the root of Dahurain angelica is mixed and adjusted with the obtained liquid medicine of step B) At medicine for external application paste;
The step A) obtained oral medicine and the step C) obtained medicine for external application forms the Chinese medicine composition.
The Chinese medicine composition obtained using preparation method provided by the invention, including oral medicine and medicine for external application, in treatment wind Inside and outside to take into account when wet osteopathy, effect is more preferable.
In above-mentioned preparation method provided by the invention, wistlet soaking in Chinese liquor to extract the effective component in wistlet, It is fully dissolved out the effective component in wistlet, improves the external application effect for the Chinese medicine composition being prepared, thus to each portion The traumatic injury and arthralgia of position play targetedly therapeutic effect.
In certain embodiments of the present invention, the step C) in, add in the powder mixture and the liquid medicine Enter flour, medicine for external application paste is tuned into after mixing.
Each raw material is stirred into paste using suitable flour, obtains medicine for external application paste, which uses Flour reconciles, and without any side effect, and flour can also absorb the toxic component in bulk pharmaceutical chemicals, makes to be prepared Drug composition is safer.
Purposes of the above-mentioned Chinese medicine composition in preparation treatment traumatic injury and painful swelling of joints drug.
Below in conjunction with embodiment and comparative example, the present invention will be further described in detail.
Embodiment 1-6 and comparative example 1-4
Embodiment 1-6 and comparative example 1-4 is a kind of Chinese medicine composition treated for treating treating rheumatic ostealgia respectively, each to implement The composition of bulk pharmaceutical chemicals in example is listed in table 1.
The bulk pharmaceutical chemicals of each embodiment and comparative example of table 1 are at being grouped as
Illustrate, in the Chinese medicine composition that embodiment 1-6 and comparative example 1-4 are provided, by ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, five when preparation Add skin, perilla leaf, Radix Angelicae Sinensis and Poria cocos to be prepared into oral medicine, external application is made in Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng, the root of Dahurain angelica and wistlet Medicine.
Efficiency assay
According to clinical interview, the Chinese medicine composition of embodiment 1-6 and comparative example 1-4 offer is utilized respectively to rheumatism bone disease Patient cures, and the corresponding patient of every group of embodiment and comparative example counts the medication of every group of patient between 10-30 people respectively Effect, statistical result are listed in table 2.Wherein, the SS of obvious effective rate is that patient indicates that pain relief or doctor observe swelling journey Degree reduction etc..
2 statistical result of table
Case one
Zhang, female 52 years old, suffer from rheumatism bone disease nearly 8 years, start migration pain, especially sleep what leg was felt bad at night It cannot sleep, the pain increased later, and sleep dare not turn over, also highly difficult on foot.The Chinese medicine of the offer of the embodiment of the present invention 2 is provided afterwards Afterwards, 2 days pain reliefs, imperceptible obvious pain during sleep after 5 days, can normally work substantially after January.
Case two
Week so-and-so, male, long-term to drive to lead to rheumatism bone disease, waist is ached, the Chinese medicine provided using the embodiment of the present invention 5 Afterwards, 3 days symptoms are alleviated, substantially without the sense of swelling and pain after 20 days.
Case three
Mr. Li, 61 years old, female, knee many years pain cannot go to work in the fields, the Chinese medicine provided using the embodiment of the present invention 5 Afterwards, 4 days pain reliefs, can walk long distances, be almost recovered after 24 days.
Case four
Song, 32 years old, male fractured at wrist because work is damaged arm, the Chinese medicine provided using the embodiment of the present invention 6 Afterwards, swelling in 4 days is subsided substantially, substantially painless after 8 days.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims Including belonging to all such changes and modifications in the scope of the invention.

Claims (10)

1. a kind of for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that including mainly by the raw material of following parts by weight The oral medicine of medicine composition: 8~12 parts of ramulus cinnamomi, 10~14 parts of pawpaw, 4~8 parts of radix achyranthis bidentatae, 12~17 parts of cortex acanthopanacis, perilla leaf 8~12 Part, 6~10 parts of Radix Angelicae Sinensis and 13~18 parts of Poria cocos.
2. according to claim 1 for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that the oral pack Include the bulk pharmaceutical chemicals of following parts by weight: 9~11 parts of ramulus cinnamomi, 11~13 parts of pawpaw, 5~7 parts of radix achyranthis bidentatae, 13~16 parts of cortex acanthopanacis, purple perilla 9~11 parts of leaf, 7~9 parts of Radix Angelicae Sinensis and 14~17 parts of Poria cocos.
3. according to claim 1 for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that the oral pack Include the bulk pharmaceutical chemicals of following parts by weight: 9.5~10.5 parts of ramulus cinnamomi, 11.5~12.5 parts of pawpaw, 5.5~6.5 parts of radix achyranthis bidentatae, cortex acanthopanacis 14 ~16 parts, 9.5~10.5 parts of perilla leaf, 7.5~8.5 parts of Radix Angelicae Sinensis and 15~16 parts of Poria cocos.
4. according to claim 1-3 for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that described Chinese medicine composition further includes the medicine for external application being mainly made of the bulk pharmaceutical chemicals of following parts by weight: 1~3 part of Rhizoma Et Radix Notopterygii, rheum officinale 0.5~1.5 Part, 0.5~1.5 part of the root of Beijing euphorbia, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of the root of Dahurain angelica and 3~5 parts of wistlet.
5. according to claim 4 for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that the outer charging Include the bulk pharmaceutical chemicals of following parts by weight: 1.5~2.5 parts of Rhizoma Et Radix Notopterygii, 0.7~1.3 part of rheum officinale, 0.7~1.3 part of the root of Beijing euphorbia, Radix Notoginseng 0.7~ 1.3 parts, 0.7~1.3 part of the root of Dahurain angelica and 3.2~4.5 parts of wistlet.
6. according to claim 4 for treating the Chinese medicine composition for the treatment of rheumatic ostealgia, which is characterized in that the outer charging Include the bulk pharmaceutical chemicals of following parts by weight: 1.7~2.2 parts of Rhizoma Et Radix Notopterygii, 0.8~1.2 part of rheum officinale, 0.8~1.2 part of the root of Beijing euphorbia, Radix Notoginseng 0.8~ 1.2 parts, 0.8~1.2 part of the root of Dahurain angelica and 3.5~4.5 parts of wistlet.
7. a kind of claim 1-3 is described in any item for treating the preparation method of the Chinese medicine composition for the treatment of rheumatic ostealgia, special Sign is, the oral medicine is obtained after ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos are pulverized and mixed.
8. a kind of claim 4-6 is described in any item for treating the preparation method of the Chinese medicine composition for the treatment of rheumatic ostealgia, special Sign is, comprising the following steps:
A the oral medicine is obtained after) being pulverized and mixed ramulus cinnamomi, pawpaw, radix achyranthis bidentatae, cortex acanthopanacis, perilla leaf, Radix Angelicae Sinensis and Poria cocos;
B) wistlet is dipped in 20~50 ° of white wine of 40~60 parts by weight sealed soak 15~20 days, obtains liquid medicine;
C the powder mixture of Rhizoma Et Radix Notopterygii, rheum officinale, the root of Beijing euphorbia, Radix Notoginseng and the root of Dahurain angelica is mixed with the obtained liquid medicine of step B)) and is tuned into cream The medicine for external application of shape;
The step A) obtained oral medicine and the step C) obtained medicine for external application forms the Chinese medicine composition.
9. preparation method according to claim 8, which is characterized in that the step C) in, the powder mixture with Flour is added in the liquid medicine, medicine for external application paste is tuned into after mixing.
10. Chinese medicine composition described in any one of claims 1-6 is in preparation treatment traumatic injury and painful swelling of joints drug Purposes.
CN201811507185.XA 2018-12-10 2018-12-10 Chinese medicine composition for treating treating rheumatic ostealgia and preparation method thereof and purposes Pending CN109620870A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311074A (en) * 2014-07-30 2016-02-10 高晓燕 Formulation for treating arthralgia
CN107260782A (en) * 2017-06-30 2017-10-20 合肥球球科技有限公司 A kind of slender acanthopanax bark spirit

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311074A (en) * 2014-07-30 2016-02-10 高晓燕 Formulation for treating arthralgia
CN107260782A (en) * 2017-06-30 2017-10-20 合肥球球科技有限公司 A kind of slender acanthopanax bark spirit

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
王绪前等: "《中药材彩色图谱》", 31 May 2015, 中国医药科技出版社 *
邱明山等: "白芷外敷联合常规药物治疗类风湿关节炎疗效观察", 《风湿病与关节炎》 *

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Application publication date: 20190416