CN109603942B - Microfluidic device and microfluidic method - Google Patents
Microfluidic device and microfluidic method Download PDFInfo
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- CN109603942B CN109603942B CN201910117613.6A CN201910117613A CN109603942B CN 109603942 B CN109603942 B CN 109603942B CN 201910117613 A CN201910117613 A CN 201910117613A CN 109603942 B CN109603942 B CN 109603942B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
Abstract
The invention provides a microfluidic device and a microfluidic method, belongs to the technical field of microfluidics, and can at least partially solve the problem that the existing microfluidic device is low in integration level. The microfluidic device comprises a first substrate and a second substrate which are arranged oppositely, wherein a liquid drop doped with paramagnetic particles is arranged between the first substrate and the second substrate, the microfluidic device further comprises a plurality of pressure detection modules arranged on one side of the first substrate, which is far away from the second substrate, a magnetic field generation module is arranged on one side of the pressure detection modules, which is far away from the first substrate, the magnetic field generation module is used for generating a magnetic field to attract the paramagnetic particles in the liquid drop, and the pressure detection module is used for detecting the pressure applied to the pressure by the magnetic field generation module.
Description
Technical Field
The invention belongs to the technical field of microfluidics, and particularly relates to a microfluidic device and a microfluidic method.
Background
Microfluidics is the precise manipulation of tiny droplets. In microfluidic devices, an experimenter is required to place a droplet to be studied between a first substrate and a second substrate. Then, the driving module in the microfluidic device realizes the movement of the droplet by changing the electric field of the environment around the droplet (for example, the droplet is charged with electricity, and the droplet is moved by the electric field force); the detection module in the microfluidic device utilizes complex and precise optical systems to determine the position of the droplets. The driving module and the detecting module are relatively independent, which is not beneficial to the integration of the system.
Disclosure of Invention
The invention at least partially solves the problem that the existing microfluidic device is difficult to integrate, and provides a microfluidic device and a microfluidic method.
The technical scheme adopted for solving the technical problem is that the microfluidic device comprises a first substrate and a second substrate which are arranged oppositely, wherein a liquid drop doped with paramagnetic particles is arranged between the first substrate and the second substrate, the microfluidic device further comprises a plurality of pressure detection modules arranged on one side of the first substrate, which is far away from the second substrate, a magnetic field generation module is arranged on one side of the pressure detection modules, which is far away from the first substrate, and is used for generating a magnetic field to attract the paramagnetic particles in the liquid drop, and the pressure detection module is used for detecting the pressure applied to the pressure detection module by the magnetic field generation module.
Optionally, the pressure detection module includes a piezoelectric film, and a first electrode disposed on a side of the piezoelectric film facing the first substrate and a second electrode disposed on a side of the piezoelectric film away from the first substrate.
Optionally, the magnetic field generating module comprises an electromagnetic coil.
Optionally, the pressure detection modules are distributed in an array or in a concentric circle.
Optionally, the method further comprises: and the driving module is used for driving the liquid drops to move.
Optionally, the driving module comprises: a common electrode provided on a surface of one of the first substrate and the second substrate facing the gap therebetween; and a plurality of driving electrodes provided on a surface of the other of the first substrate and the second substrate facing the gap therebetween.
Optionally, the method further comprises: a dielectric layer covering the common electrode and a hydrophobic layer covering the dielectric layer; a dielectric layer covering the driving electrode and a hydrophobic layer covering the dielectric layer.
According to a second aspect of the present invention, there is provided a microfluidic method applied to the microfluidic device provided in the first aspect of the present invention, the method comprising:
disposing a droplet doped with paramagnetic particles between the first and second substrates;
driving the magnetic field generation module to generate a magnetic field;
acquiring pressure data detected by each pressure detection module;
determining a location of the droplet based on the pressure data.
Optionally, the paramagnetic particles comprise biological magnetic beads.
Optionally, said determining the location of the droplet from the pressure data comprises:
and determining the position of the pressure detection module corresponding to the pressure data with the maximum pressure value in the pressure data as the position of the liquid drop.
Optionally, the method further comprises the step of controlling the movement of said droplets, comprising:
controlling the magnetic field generation module not to generate a magnetic field;
applying a common voltage to the common electrode;
and applying a driving voltage to one or adjacent multiple driving electrodes, and applying a common voltage to the rest of the driving electrodes.
Drawings
Fig. 1 is a top perspective view of a partial structure of a microfluidic device according to an embodiment of the present invention;
fig. 2 is a cross-sectional view of a magnetic field generating module in a microfluidic device according to an embodiment of the present invention when no magnetic field is generated;
fig. 3 is a cross-sectional view of a magnetic field generating module in a microfluidic device according to an embodiment of the present invention generating a magnetic field;
wherein the reference numerals are: 1. a first substrate; 2. a second substrate; 3. a droplet; 4. A pressure detection module; 41. a piezoelectric film; 42. a first electrode; 43. a second electrode; 5. A magnetic field generating module; 51. an electromagnetic coil; 52. an insulating layer; 53. a paramagnetic particle; 6. A drive module; 61. a common electrode; 62. a drive electrode; 63. a dielectric layer; 64. a hydrophobic layer.
Detailed Description
In order to make the technical solutions of the present invention better understood, the present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
Example 1:
the embodiment provides a microfluidic device, and referring to fig. 1 to 3, the microfluidic device includes a first substrate 1 and a second substrate 2, which are oppositely disposed, a droplet 3 doped with paramagnetic particles 53 is disposed between the first substrate 1 and the second substrate 2, the microfluidic device further includes a plurality of pressure detection modules 4 disposed on a side of the first substrate 1 away from the second substrate 2, a magnetic field generation module 5 is disposed on a side of the pressure detection module 4 away from the first substrate 1, the magnetic field generation module 5 is configured to generate a magnetic field to attract the paramagnetic particles 53 in the droplet 3, and the pressure detection module 4 is configured to detect a pressure applied thereto by the magnetic field generation module 5.
In performing experiments using the microfluidic device, it is necessary to incorporate paramagnetic particles 53 into the droplet 3 and to place the droplet 3 between the first substrate 1 and the second substrate 2. The magnetic field generated by the magnetic field generating module 5 attracts the paramagnetic particles 53, thereby moving the paramagnetic particles 53 toward the magnetic field generating module 5, and the paramagnetic particles 53 are blocked by the first substrate 1. Due to the mutual attraction between the paramagnetic particles 53 and the magnetic field generating module 5, the magnetic field generating module 5 may also press the pressure detecting module 4. I.e. the pressure detection module 4 at the location with the droplet 3 is subjected to a greater pressure than the pressure detection module 4 at the location without the droplet 3. The current position of the droplet 3 can be determined by analyzing the detection signal of the pressure detection module 4.
Thus, the present invention provides a new microfluidic device structure. Further, the pressure detection module 4 and the magnetic field generation module 5 do not require a complicated and precise optical system, are relatively simpler in structure, and are more easily integrated with the drive module 6, which is an electronic system, because they can be formed of electronic devices.
Alternatively, the pressure detection module 4 includes a piezoelectric film 41, and a first electrode 42 disposed on a side of the piezoelectric film 41 facing the first substrate 1 and a second electrode 43 disposed on a side of the piezoelectric film 41 facing away from the first substrate 1.
When the piezoelectric film 41 is acted by an external force, a polarization phenomenon is generated in the piezoelectric film, so that positive and negative charges are respectively accumulated on two opposite surfaces. The polarization phenomenon disappears after the external force is removed. The amount of charge generated when the piezoelectric film 41 is polarized is proportional to the pressure to which it is subjected. The magnitude of the pressure applied to the piezoelectric thin film 41 is determined by detecting the amount of open-circuit charge on both surfaces of the piezoelectric thin film. So that the current position of the droplet 3 can be calculated from these pressure data.
Optionally, the magnetic field generating module 5 comprises an electromagnetic coil 51. I.e. in particular by the electromagnetic coil 51. In order to avoid short-circuiting the electromagnetic coil 51 with the first electrode 42, an insulating layer 52 is also provided therebetween.
Optionally, the plurality of pressure detection modules 4 are distributed in an array or in concentric circles. For example, as shown in fig. 1, the pressure detection modules 4 (specifically, the piezoelectric film 41) are distributed in an array. Of course, the distribution of the pressure detection modules 4 may be of other types.
Optionally, the microfluidic device further comprises: a drive module 6 for driving the movement of the droplets 3. I.e. the movement of the droplets 3 is driven by the drive module 6, so that their properties are observed.
Optionally, the drive module 6 comprises: a common electrode 61 provided on a surface of one of the first substrate 1 and the second substrate 2 facing a gap therebetween; and a plurality of driving electrodes 62 provided on a surface of the other of the first substrate 1 and the second substrate 2 facing the gap therebetween.
A common voltage may be applied to the common electrode 61 to provide a stable reference voltage. The common electrode 61 may be of a whole plate structure or may be divided into a plurality of pieces as long as they are applied with a common voltage in an applied state.
The plurality of driving electrodes 62 apply different voltages to the respective driving electrodes 62 to generate a non-uniform electric field, so that the droplet 3 (in this case, the droplet 3 should be charged) is moved between the first substrate 1 and the second substrate 2 by the electric field force.
Specifically, the common electrode 61 is provided on the first substrate 1 or the second substrate 2, and may be flexibly provided by those skilled in the art. This is not necessarily restrictive.
Optionally, the method further comprises: a dielectric layer 63 covering the common electrode 61 and a hydrophobic layer 64 covering the dielectric layer 63; a dielectric layer 63 covering the driving electrode 62 and a hydrophobic layer 64 covering the dielectric layer 63.
A dielectric layer 63 covers the common electrode 61 and the drive electrode 62, insulating these two electrodes from the droplets 3. The hydrophobic layer 64 covering the two medium layers 63 is to make the droplet 3 in a hydrophobic state, and the droplet 3 does not move.
In this embodiment, the liquid droplets 3 can also be moved by applying a drive voltage to a part of the drive electrodes 62 and applying a common voltage to the other part of the drive electrodes 62 so that the liquid droplets 3 become hydrophilic.
Example 2:
this example provides a microfluidic method, applied to the microfluidic device of example 1 of the present invention, and referring to fig. 1 to 3, the method includes:
a droplet 3 doped with paramagnetic particles 53 is disposed between the first substrate 1 and the second substrate 2;
the driving magnetic field generation module 5 generates a magnetic field;
acquiring pressure data detected by each pressure detection module 4;
the position of the droplet 3 is determined from the pressure data.
Optionally, the paramagnetic particles 53 comprise biological magnetic beads.
The biomagnetic beads are superparamagnetic microspheres with a fine diameter. Can be rapidly gathered under the action of a magnetic field and can be uniformly distributed in a magnetic separation mode after the magnetic field is removed. This allows for a shorter time delay for the detection of pressure (i.e., the detection of position).
In addition, the sample to be tested usually contains biochemical and other substances to be analyzed. The surface of the biological magnetic bead can be added with a modified active group, can be coupled with a biochemical substance to be analyzed, and can separate the biochemical substance to be analyzed from a sample to be detected under the action of an external magnetic field.
Optionally, determining the position of the droplet 3 from the pressure data comprises: and determining the position of the pressure detection module 4 corresponding to the pressure data with the maximum pressure value in the pressure data as the position of the liquid drop 3.
Of course, those skilled in the art may also fit the pressure data and the corresponding position coordinates of the pressure detection module 4 to obtain a functional relationship between the pressure data and the position coordinates, and determine the position of the droplet 3 by analyzing the functional relationship (the position coordinate of the maximum pressure in the function is the position coordinate of the droplet 3).
Optionally, the method further comprises the step of controlling the movement of the droplet 3, comprising:
controlling the magnetic field generation module 5 not to generate a magnetic field;
applying a common voltage to the common electrode 61;
a drive voltage is applied to one or adjacent ones of the drive electrodes 62, and a common voltage is applied to the remaining drive electrodes 62.
I.e. when the paramagnetic particles 53 are homogeneously distributed in the droplet 3, the movement of the droplet 3 is driven by generating a non-uniform electric field.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and substance of the invention, and these modifications and improvements are also considered to be within the scope of the invention.
Claims (6)
1. A micro-fluidic device comprises a first substrate and a second substrate which are oppositely arranged, and is characterized in that a liquid drop doped with paramagnetic particles is arranged between the first substrate and the second substrate, the micro-fluidic device further comprises a plurality of pressure detection modules arranged on one side of the first substrate far away from the second substrate, each pressure detection module comprises a piezoelectric film, a first electrode arranged on the side, facing the first substrate, of the piezoelectric film, and a second electrode arranged on the side, far away from the first substrate, of the piezoelectric film;
a magnetic field generation module is arranged on one side, far away from the first substrate, of the pressure detection module, the magnetic field generation module comprises an electromagnetic coil, the magnetic field generation module is used for generating a magnetic field to attract paramagnetic particles in the liquid drops, and the pressure detection module is used for detecting the pressure applied to the pressure generation module by the magnetic field generation module;
the microfluidic device further comprises a drive module for driving the movement of the droplets, the drive module comprising: a common electrode provided on a surface of one of the first substrate and the second substrate facing the gap therebetween; and a plurality of driving electrodes provided on a surface of the other of the first substrate and the second substrate facing the gap therebetween.
2. The microfluidic device according to claim 1, wherein the plurality of pressure detection modules are distributed in an array or in concentric circles.
3. The microfluidic device according to claim 1, further comprising:
a dielectric layer covering the common electrode and a hydrophobic layer covering the dielectric layer;
a dielectric layer covering the driving electrode and a hydrophobic layer covering the dielectric layer.
4. A microfluidic control method applied to the microfluidic device according to any one of claims 1 to 3, the method comprising:
disposing a droplet doped with paramagnetic particles between the first and second substrates;
driving the magnetic field generation module to generate a magnetic field;
acquiring pressure data detected by each pressure detection module;
determining a location of the droplet based on the pressure data.
5. The microfluidic method of claim 4, wherein said determining the location of the droplet based on the pressure data comprises:
and determining the position of the pressure detection module corresponding to the pressure data with the maximum pressure value in the pressure data as the position of the liquid drop.
6. The microfluidic method of claim 4, further comprising the step of controlling the movement of the droplet, comprising:
controlling the magnetic field generation module not to generate a magnetic field;
applying a common voltage to the common electrode;
and applying a driving voltage to one or adjacent multiple driving electrodes, and applying a common voltage to the rest of the driving electrodes.
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| CN115245845A (en) * | 2021-04-27 | 2022-10-28 | 上海天马微电子有限公司 | Micro-fluidic chip |
Citations (2)
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| WO2014164731A1 (en) * | 2013-03-11 | 2014-10-09 | University Of Utah Research Foundation | Sensor systems |
| CN106796175A (en) * | 2014-08-08 | 2017-05-31 | 宽腾矽公司 | For detect, detect and analyzing molecules optical system and detection chip |
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| US7439014B2 (en) * | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| EP2573562A3 (en) * | 2007-02-09 | 2013-10-30 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods employing magnetic beads |
| DE102010001412A1 (en) * | 2010-02-01 | 2011-08-04 | Robert Bosch GmbH, 70469 | Microfluidic device for handling a fluid and microfluidic chip |
| EP2829882B8 (en) * | 2012-03-21 | 2020-04-01 | NEC Corporation | Chip for analysis of target substance |
| CN103170384B (en) * | 2013-05-06 | 2015-03-04 | 复旦大学 | Large and small droplet control based digital micro-fluidic chip |
| JP2017504016A (en) * | 2013-12-23 | 2017-02-02 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | Microfluidic device, system and method |
| EP3209419A4 (en) * | 2014-10-22 | 2018-10-03 | The Regents of The University of California | High definition microdroplet printer |
| JP6506094B2 (en) * | 2015-04-30 | 2019-04-24 | シスメックス株式会社 | Test substance detection method and sample analyzer |
| CN107527595B (en) * | 2017-09-27 | 2019-06-07 | 京东方科技集团股份有限公司 | A kind of microfluidic system and its driving method |
| CN108355728B (en) * | 2018-03-26 | 2020-01-07 | 京东方科技集团股份有限公司 | Chip substrate and digital microfluidic chip |
| CN108479875A (en) * | 2018-06-01 | 2018-09-04 | 东莞东阳光科研发有限公司 | A kind of digital microcurrent-controlled chip report control platform |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014164731A1 (en) * | 2013-03-11 | 2014-10-09 | University Of Utah Research Foundation | Sensor systems |
| CN106796175A (en) * | 2014-08-08 | 2017-05-31 | 宽腾矽公司 | For detect, detect and analyzing molecules optical system and detection chip |
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