CN109589905B - Clinical pharmacy reagent preparation device and preparation method thereof - Google Patents
Clinical pharmacy reagent preparation device and preparation method thereof Download PDFInfo
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- CN109589905B CN109589905B CN201811509973.2A CN201811509973A CN109589905B CN 109589905 B CN109589905 B CN 109589905B CN 201811509973 A CN201811509973 A CN 201811509973A CN 109589905 B CN109589905 B CN 109589905B
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims description 18
- 230000007246 mechanism Effects 0.000 claims abstract description 65
- 238000003756 stirring Methods 0.000 claims abstract description 49
- 230000001105 regulatory effect Effects 0.000 claims abstract description 28
- 238000009434 installation Methods 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000007704 transition Effects 0.000 claims description 25
- 239000002994 raw material Substances 0.000 claims description 24
- 238000003780 insertion Methods 0.000 claims description 11
- 230000037431 insertion Effects 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 230000003014 reinforcing effect Effects 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 4
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 229940121657 clinical drug Drugs 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 6
- 238000012360 testing method Methods 0.000 abstract description 6
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 3
- 230000008878 coupling Effects 0.000 description 11
- 238000010168 coupling process Methods 0.000 description 11
- 238000005859 coupling reaction Methods 0.000 description 11
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/20—Stationary reactors having moving elements inside in the form of helices, e.g. screw reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00004—Scale aspects
- B01J2219/00011—Laboratory-scale plants
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- Chemical Kinetics & Catalysis (AREA)
- Feeding And Watering For Cattle Raising And Animal Husbandry (AREA)
Abstract
The invention discloses a clinical pharmacy reagent preparing device and a preparing method thereof, wherein the preparing device comprises an installation support and a flow guide cover uniformly distributed on the edge of the top of the installation support, the bottom end of the flow guide cover is vertically connected with a flow guide connection mechanism, the bottom end of the flow guide connection mechanism is connected with a flow regulating mechanism through a connection hose, the bottom of the flow regulating mechanism is connected with a positioning connection seat, the center of the bottom of the positioning connection seat is provided with a stirring mechanism, the center of the top of the positioning connection seat is connected with the top end of the installation support through a lifting connection seat, and the center of the bottom of the. According to the invention, through scientific and reasonable structural design, not only can the pharmaceutical reagent be rapidly modulated and fully reacted, but also the pharmaceutical reagent can be rapidly disassembled and assembled, the sufficiency of the pharmaceutical reaction and the accuracy of test data in the modulation process are ensured through the structural design of the stirring mechanism, the automation degree of the whole device is high, and the device has good practical and popularization values.
Description
Technical Field
The invention belongs to the field of pharmaceutical reagents, and particularly relates to a clinical pharmaceutical reagent preparation device and a preparation method thereof.
Background
In the development and preparation stage of clinical pharmacy, several pharmaceutical reagents are generally stirred and mixed together, so that corresponding pharmaceutical reactions occur, the test phenomenon can be observed, test data can be collected, and the mixing uniformity of the pharmaceutical reagents directly influences the sufficiency of the pharmaceutical reactions and the accuracy of the test data. And how to add and stir various reagents fast, very big influence clinical work efficiency.
Disclosure of Invention
The invention aims to overcome the problems in the prior art and provides a clinical pharmaceutical reagent preparing device and a preparing method thereof, which not only can quickly prepare and fully react a pharmaceutical reagent, but also can be quickly disassembled and assembled and are convenient to clean.
In order to achieve the technical purpose and achieve the technical effect, the invention is realized by the following technical scheme:
a clinical pharmacy reagent modulating device comprises an installation support and flow guide covers uniformly distributed on the edge of the top of the installation support, wherein the bottom ends of the flow guide covers are vertically connected with a flow guide connecting mechanism, the bottom ends of the flow guide connecting mechanism are connected with a flow regulating mechanism through a connecting hose, the bottom of the flow regulating mechanism is connected with a positioning connecting seat, the center of the bottom of the positioning connecting seat is provided with a stirring mechanism, the center of the top of the positioning connecting seat is connected with the top of the installation support through a lifting connecting seat, and the center of the bottom of the installation support is vertically provided;
the mounting bracket comprises an annular mounting seat and supporting columns uniformly distributed at the bottom edge of the annular mounting seat, supporting connecting rods are uniformly distributed at the edge of the surface of the annular mounting seat, a supporting top plate is horizontally mounted at the top ends of the supporting connecting rods, mounting jacks are uniformly distributed at the edge of the surface of the supporting top plate, a guide sleeve is arranged in the center of the bottom surface of the supporting top plate, and four limiting slots are uniformly distributed on the periphery of the annular mounting seat;
the lifting connecting seat comprises a lifting connecting plate, lifting connecting rods fixedly connected with the positioning connecting seat are uniformly distributed on the edge of the bottom of the lifting connecting plate, and a sliding connecting cylinder in sliding connection with the guide sleeve is vertically arranged in the center of the surface of the lifting connecting plate; a telescopic oil cylinder is vertically arranged in the guide sleeve, the top end of the telescopic oil cylinder is fixedly connected with the supporting top plate, and the bottom end of the telescopic oil cylinder is fixedly connected with the lifting connecting plate; the positioning connecting seat comprises a positioning connecting plate, internal thread sleeves are uniformly distributed on the edge of the surface of the positioning connecting plate, a driving motor is vertically arranged in the center of the positioning connecting plate, and a protective housing is arranged outside the driving motor;
the flow guide connecting mechanism comprises a flow guide support and a flow guide connecting pipe which are installed in a matched mode, the flow guide support comprises a flow guide vertical plate which is vertically fixed on the bottom surface of the supporting top plate, a clamping bottom plate is vertically arranged at the bottom of the flow guide vertical plate, a clamping hole is formed in the center of the clamping bottom plate, two horizontally distributed elastic clamping strips are symmetrically arranged in the middle of the flow guide vertical plate, and arc-shaped clamping grooves matched with the flow guide connecting pipe are formed in the inner side surfaces of the; the middle of the diversion connecting pipe is provided with a switch valve, and the bottom end of the diversion connecting pipe is provided with a conical diversion cylinder with a wide upper part and a narrow lower part;
the flow regulating mechanism comprises a drainage connecting piece, a confluence mechanism, a transition connecting seat and a rotary regulating seat which are sequentially arranged from top to bottom, and a drainage connecting piece is vertically arranged in the middle of the transition connecting seat;
the rotary adjusting seat comprises an external thread sleeve matched with the internal thread sleeve, and the top end of the external thread sleeve is provided with an annular bulge; the drainage connecting piece comprises a rotary mounting block, a drainage conduit is arranged in the center of the bottom surface of the rotary mounting block, and an external threaded pipe is arranged in the center of the top surface of the rotary mounting block;
the confluence mechanism comprises three confluence assembly parts which are uniformly distributed along the circumferential direction, and two adjacent confluence assembly parts are connected through a limiting plug-in;
the confluence assembly comprises an arc-shaped vertical plate with a section being a one-third circular ring, a first arc-shaped connecting block is vertically arranged in the center of the top surface of the arc-shaped vertical plate, a second arc-shaped connecting block is vertically arranged in the center of the bottom surface of the arc-shaped vertical plate, limiting grooves are uniformly distributed in the vertical direction on the left end surface of the arc-shaped vertical plate, a first limiting clamping groove is vertically arranged in the center of the left end surface of the arc-shaped vertical plate, limiting protrusions are uniformly distributed in the vertical direction on the right end surface of the arc-shaped vertical plate, a second limiting clamping groove is vertically arranged; the outer surfaces of the three first arc-shaped connecting blocks form first external threads together, and the outer surfaces of the three second arc-shaped connecting blocks form second external threads together;
the limiting plug-in comprises a first limiting clamping strip and a second limiting clamping strip which are connected with each other; interference fit is respectively formed between the first limiting clamping strip and the first limiting clamping groove and between the second limiting clamping strip and the second limiting clamping groove;
the transition connecting seat comprises a transition connecting cylinder matched with the second external thread and a transition connecting bulge arranged at the top end of the transition connecting cylinder, a transition connecting bottom plate is arranged at the bottom of the transition connecting cylinder, a first annular pressure stop plate is arranged at the top end of the inner side surface of the transition connecting cylinder, a central boss is arranged in the center of the inner surface of the transition connecting bottom plate, an internal thread adjusting hole matched with the external thread pipe is arranged in the center of the bottom surface of the central boss, and flow guide long grooves distributed along the axis are uniformly distributed on the periphery of the internal thread adjusting hole along the;
the drainage connecting piece comprises a drainage connecting cylinder matched with the first external thread, a second annular pressure stop plate is arranged at the bottom end of the inner side surface of the drainage connecting cylinder, a conical connecting pipe is arranged at the top end of the drainage connecting cylinder, a drainage connecting head is arranged at the top end of the conical connecting pipe, and the drainage connecting head is communicated with the bottom end of the conical guide cylinder through a connecting hose;
the bottom end of the flow guide sleeve is provided with a flow guide insertion pipe, and the bottom end of the flow guide insertion pipe penetrates through the installation insertion hole to be communicated with the flow guide connecting pipe;
support connecting grooves corresponding to the limiting slots are uniformly distributed on the periphery of the top end of the mixing barrel, the limiting slots are connected with the support connecting grooves through limiting insertion blocks, and elastic limiting belts are mounted at the outer ends of the limiting insertion blocks;
the stirring mechanism comprises a stirring installation shaft vertically fixed at the bottom end of the driving motor, rotary connecting pieces are uniformly distributed on the outer side of the stirring installation shaft along the axis direction, two reinforcing connecting rods are symmetrically installed in the middle of each rotary connecting piece, and adjacent rotary connecting pieces are connected through spiral stirring blades;
the periphery of the stirring installation shaft is symmetrically provided with two rotating clamping grooves, the rotating connecting piece comprises a central connecting block and rotating connecting strips symmetrically arranged on two sides of the central connecting block, the center of the central connecting block is provided with a stirring installation hole matched with the stirring installation shaft, the periphery of the stirring installation hole is symmetrically provided with rotating limiting bulges matched with the rotating clamping grooves, and the middle of each rotating connecting strip is provided with a fixed connecting hole matched with the reinforcing connecting rod; spiral stirring leaf includes the arc connection piece, and arc connection piece both ends are equipped with vertical distribution's first stationary blade and second stationary blade respectively.
Furthermore, the inner diameter of the clamping hole is larger than the outer diameter of the edge of the lower end of the conical guide cylinder and smaller than the outer diameter of the edge of the upper end of the conical guide cylinder.
Furthermore, one of the rotary connecting strips is fixedly connected with the second fixing piece of the spiral stirring blade below the rotary connecting strip, and the other rotary connecting strip is fixedly connected with the first fixing piece of the spiral stirring blade above the rotary connecting strip.
Furthermore, the reinforcing connecting rod and the fixed connecting hole are in interference fit.
Further, the annular protrusion is fixedly connected with the transition connecting protrusion through a bolt.
Furthermore, the lifting connecting rod is connected with the positioning connecting plate through welding.
Further, the inside bottom of internal thread cover has sealed baffle through torsional spring horizontal installation.
The invention also provides a preparation method of the clinical pharmaceutical reagent, which comprises the following steps:
the method comprises the following steps: firstly, assembling a flow guide cover, a flow guide connecting mechanism, a connecting hose, a flow regulating mechanism, a positioning connecting seat, a stirring mechanism, a lifting connecting seat and a mixing barrel in sequence;
step two: opening the same number of switch valves according to the number of the required reagent raw materials, and determining the discharge capacity of the flow regulating mechanism according to the proportion of each reagent raw material;
step three: pouring all reagent raw materials into the air guide sleeve connected with the corresponding flow regulating mechanism respectively, and rotating the rotary regulating seat downwards until the drainage conduit passes through the plane where the positioning connecting plate is located;
step four: all the reagent raw materials sequentially pass through the air guide sleeve, the air guide connecting mechanism, the connecting hose and the flow regulating mechanism and are mixed and stored in the mixing barrel to form a reagent raw material mixed solution;
step five: then sequentially opening the driving motor and the telescopic oil cylinder, and closing the telescopic oil cylinder when the stirring mechanism is completely immersed in the reagent raw material mixed liquid;
step six: and stirring the mixed solution of the raw materials of the reagent according to the preset time to finally form a finished product reagent.
Further, the specific step of determining the displacement of the flow regulating mechanism in the second step is as follows: slowly screwing the external thread pipe into the internal thread adjusting hole;
when the top end of the external threaded pipe is level with the bottom end of the flow guide long groove, a first scale mark is engraved at the intersection of the bottom surface of the transitional connection bottom plate and the outer surface of the external threaded pipe;
when the top end of the external threaded pipe is level with the top end of the flow guide long groove, a second scale mark is engraved at the intersection of the bottom surface of the transitional connection bottom plate and the outer surface of the external threaded pipe;
equally dividing lines are marked between the first scale mark and the second scale mark, and corresponding percentage numbers are marked sequentially from top to bottom according to the sequence from small to large;
and determining a corresponding dividing line on the external thread pipe according to the proportion of the reagent raw materials, and continuously rotating the external thread pipe until the dividing line and the bottom surface of the transitional connection bottom plate are positioned on the same plane.
The invention has the beneficial effects that:
through scientific and reasonable structural design, the device not only can quickly modulate and fully react the pharmaceutical reagent, but also can quickly disassemble and install, ensures the sufficiency of the pharmaceutical reaction and the accuracy of test data in the modulating process through the structural design of the stirring mechanism, has high automation degree, simple structure and convenient use, can be quickly cleaned when in use or after in use, greatly improves the clinical work efficiency, and has good practical and popularization values.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention. In the drawings:
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of a portion of the present invention;
FIG. 3 is an exploded view of a portion of the structure of the present invention;
FIG. 4 is a schematic view of a partial structure of the present invention;
FIG. 5 is an exploded view of a portion of the structure of the present invention;
FIG. 6 is a schematic view of a partial structure of the present invention;
FIG. 7 is a partial sectional view of the construction of the present invention;
FIG. 8 is an exploded view of a portion of the structure of the present invention;
FIG. 9 is a schematic view of a portion of the present invention;
FIG. 10 is a schematic view of a portion of the present invention;
FIG. 11 is a partial schematic view of the present invention;
FIG. 12 is a partial sectional view of the construction of the present invention;
FIG. 13 is a partial structural cross-sectional view of the present invention;
FIG. 14 is a partial schematic structural view of the present invention;
FIG. 15 is an exploded view of a portion of the structure of the present invention;
FIG. 16 is a partial schematic structural view of the present invention;
fig. 17 is an exploded view of a portion of the structure of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "opening," "upper," "lower," "thickness," "top," "middle," "length," "inner," "peripheral," and the like are used in an orientation or positional relationship that is merely for convenience in describing and simplifying the description, and do not indicate or imply that the referenced component or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered as limiting the present invention.
As shown in figure 1, clinical pharmacy reagent modulating device, including installing support 1 and the kuppe 2 of equipartition at installing support 1 top edge, the vertical water conservancy diversion coupling mechanism 3 that is connected with in kuppe 2 bottom, 3 bottoms of water conservancy diversion coupling mechanism are connected with flow control mechanism 5 through coupling hose 4, 5 bottoms of flow control mechanism are connected with location connecting seat 6, 6 bottom central authorities of location connecting seat install rabbling mechanism 7, 6 top central authorities of location connecting seat link with installing support 1 top through lift connecting seat 8 and link to each other, 1 bottom central authorities of installing support vertically install blending tank 9.
As shown in fig. 2, the mounting bracket 1 includes an annular mounting seat 11 and support columns 12 uniformly distributed at the bottom edge of the annular mounting seat 11, support connecting rods 13 are uniformly distributed at the surface edge of the annular mounting seat 11, a support top plate 14 is horizontally mounted at the top end of the support connecting rods 13, mounting jacks 15 are uniformly distributed at the surface edge of the support top plate 14, a guide sleeve 16 is arranged at the center of the bottom surface of the support top plate 14, and four limit slots 17 are uniformly distributed at the periphery of the annular mounting seat 11.
As shown in fig. 3, the lifting connection seat 8 includes a lifting connection plate 81, lifting connection rods 83 fixedly connected to the positioning connection seat 6 are uniformly distributed on the bottom edge of the lifting connection plate 81, and a sliding connection cylinder 82 slidably connected to the guide sleeve 16 is vertically arranged in the center of the surface of the lifting connection plate 81; a telescopic oil cylinder is vertically arranged in the guide sleeve 16, the top end of the telescopic oil cylinder is fixedly connected with the supporting top plate 14, and the bottom end of the telescopic oil cylinder is fixedly connected with the lifting connecting plate 81; the positioning connecting seat 6 comprises a positioning connecting plate 61, inner thread sleeves 62 are evenly distributed on the edge of the surface of the positioning connecting plate 61, a driving motor 63 is vertically installed in the center of the positioning connecting plate 61, and a protective cover shell 64 is installed outside the driving motor 63.
As shown in fig. 4 and 5, the flow guiding connection mechanism 3 includes a flow guiding support 31 and a flow guiding connection pipe 32 which are installed in a mutually matched manner, the flow guiding support 31 includes a flow guiding vertical plate 311 vertically fixed on the bottom surface of the supporting top plate 14, a clamping bottom plate 312 is vertically arranged at the bottom of the flow guiding vertical plate 311, a clamping hole 313 is arranged in the center of the clamping bottom plate 312, two horizontally distributed elastic clamping strips 314 are symmetrically arranged in the middle of the flow guiding vertical plate 311, and arc-shaped clamping grooves 315 matched with the flow guiding connection pipe 32 are arranged on the inner side surfaces of the; the middle of the guide connection pipe 32 is provided with a switch valve 322, and the bottom of the guide connection pipe 32 is provided with a tapered guide cylinder 321 with a wide top and a narrow bottom.
As shown in fig. 6 and 7, the flow rate adjusting mechanism 5 includes a drainage connector 51, a confluence mechanism 52, a transition connecting seat 53, and a rotation adjusting seat 54, which are sequentially installed from top to bottom, and a drainage connector 55 is vertically installed in the middle of the transition connecting seat 53.
As shown in fig. 8, the rotary adjusting seat 54 includes an external thread sleeve 542 matching with the internal thread sleeve 62, and the top end of the external thread sleeve 542 is provided with an annular protrusion 541; drain connector 55 includes a rotatable mounting block 551 having a drain conduit 553 centrally located on the bottom surface of rotatable mounting block 551 and an externally threaded tube 552 centrally located on the top surface of rotatable mounting block 551.
As shown in fig. 9, the bus mechanism 52 includes three bus assemblies 521 uniformly distributed in the circumferential direction, and two adjacent bus assemblies 521 are connected by a stopper insert 522.
As shown in fig. 10, the confluence assembly 521 includes an arc-shaped vertical plate 5211 with a section being a one-third circular ring, a first arc-shaped connection block 5212 is vertically arranged in the center of the top surface of the arc-shaped vertical plate 5211, a second arc-shaped connection block 5213 is vertically arranged in the center of the bottom surface of the arc-shaped vertical plate 5211, limit grooves 5215 are uniformly distributed in the vertical direction on the left end surface of the arc-shaped vertical plate 5211, a first limit slot 5216 is vertically arranged in the center of the left end surface of the arc-shaped vertical plate 5211, limit protrusions 5217 are uniformly distributed in the vertical direction on the right end surface of the arc-shaped vertical plate 5211, a second limit slot 5218 is vertically arranged in the center of the; the outer surfaces of the three first arc-shaped connecting blocks 5212 collectively form first external threads, and the outer surfaces of the three second arc-shaped connecting blocks 5213 collectively form second external threads.
As shown in fig. 11, the stop insert 522 includes a first stop strip 5221 and a second stop strip 5222 that are connected to each other; interference fit is respectively formed between the first limiting clamping strip 5221 and the first limiting clamping groove 5216 and between the second limiting clamping strip 5222 and the second limiting clamping groove 5218.
As shown in fig. 12, the transitional coupling seat 53 includes a transitional coupling cylinder 531 matching with the second external thread and a transitional coupling protrusion 532 disposed at the top end of the transitional coupling cylinder 531, a transitional coupling bottom plate 534 is disposed at the bottom of the transitional coupling cylinder 531, a first annular pressure stop plate 533 is disposed at the top end of the inner side surface of the transitional coupling cylinder 531, a central boss 535 is disposed at the center of the inner surface of the transitional coupling bottom plate 534, an internal thread adjusting hole 536 matching with the external thread pipe 552 is disposed at the center of the bottom surface of the central boss 535, and flow guiding long grooves 537 distributed along the axis are uniformly distributed on the circumferential side of the internal thread adjusting.
As shown in fig. 13, the drainage connector 51 includes a drainage connecting cylinder 511 matching with the first external thread, a second annular pressure-stopping plate 512 is disposed at the bottom end of the inner side surface of the drainage connecting cylinder 511, a conical connecting pipe 513 is disposed at the top end of the drainage connecting cylinder 511, a drainage connector 514 is disposed at the top end of the conical connecting pipe 513, and the drainage connector 514 is communicated with the bottom end of the conical guiding cylinder 321 through a connecting hose 4.
As shown in fig. 14, the bottom end of the diversion cover 2 is provided with a diversion cannula 21, and the bottom end of the diversion cannula 21 passes through the installation insertion hole 15 to be communicated with a diversion connection pipe 32.
As shown in fig. 15, the supporting and connecting grooves 91 corresponding to the limiting slots 17 are uniformly distributed on the periphery of the top end of the mixing barrel 9, the limiting slots 17 are connected with the supporting and connecting grooves 91 through limiting insertion blocks 92, and elastic limiting belts 10 are installed at the outer ends of the limiting insertion blocks 92.
As shown in fig. 16, the stirring mechanism 7 includes a stirring installation shaft 71 vertically fixed at the bottom end of the driving motor 63, rotary connectors 72 are uniformly distributed on the outer side of the stirring installation shaft 71 along the axial direction, two reinforcing connecting rods 73 are symmetrically installed in the middle of the rotary connectors 72, and adjacent rotary connectors 72 are connected through spiral stirring blades 74.
As shown in fig. 17, two rotating slots 711 are symmetrically disposed around the stirring mounting shaft 71, the rotating connector 72 includes a central connecting block 721 and rotating connecting strips 724 symmetrically disposed on two sides of the central connecting block 721, a stirring mounting hole 722 matched with the stirring mounting shaft 71 is disposed in the center of the central connecting block 721, rotating limiting protrusions 723 matched with the rotating slots 711 are symmetrically disposed around the stirring mounting hole 722, and a fixing connecting hole 725 matched with the reinforcing connecting rod 73 is disposed in the middle of the rotating connecting strips 724; the spiral stirring blade 74 includes an arc-shaped connecting sheet 741, and a first fixing sheet 742 and a second fixing sheet 743 which are vertically distributed are respectively disposed at two ends of the arc-shaped connecting sheet 741.
Wherein, the inside diameter of joint hole 313 is greater than toper draft tube 321 lower extreme edge external diameter and is less than toper draft tube 321 upper end edge external diameter, one of them swivelling joint strip 724 in the swivel connected coupler 72 is fixed continuous with the second stationary blade 743 of the spiral stirring leaf 74 of its below, another swivelling joint strip 724 in this swivel connected coupler 72 is fixed continuous with the first stationary blade 742 of the spiral stirring leaf 74 of its top, be interference fit between reinforcement connecting rod 73 and the fixed connection hole 725, pass through bolt fixed connection between annular arch 541 and the transition connection arch 532, link to each other through the welding between lift connecting rod 83 and the locating connection board 61, there is a sealing baffle at the inside bottom of interior thread bush 62 through torsional spring horizontal installation.
The invention also provides a preparation method of the clinical pharmaceutical reagent, which comprises the following steps:
the method comprises the following steps: firstly, assembling a flow guide cover 2, a flow guide connecting mechanism 3, a connecting hose 4, a flow regulating mechanism 5, a positioning connecting seat 6, a stirring mechanism 7, a lifting connecting seat 8 and a mixing barrel 9 in sequence;
step two: opening the same number of switch valves 322 according to the number of the required reagent raw materials, and determining the discharge capacity of the flow regulating mechanism 5 according to the proportion of each reagent raw material;
the specific steps for determining the displacement of the flow regulating mechanism 5 are as follows: slowly screwing the externally threaded tube 552 into the internally threaded adjustment bore 536; when the top end of the external threaded pipe 552 is flush with the bottom end of the diversion long groove 537, a first scale mark is engraved at the intersection of the bottom surface of the transitional connection base plate 534 and the outer surface of the external threaded pipe 552; when the top end of the external threaded pipe 552 is flush with the top end of the diversion long groove 537, a second scale mark is engraved at the intersection of the bottom surface of the transitional connection base plate 534 and the outer surface of the external threaded pipe 552; equally dividing lines are marked between the first scale mark and the second scale mark, and corresponding percentage numbers are marked sequentially from top to bottom according to the sequence from small to large; determining a corresponding dividing line on the external thread pipe 552 according to the proportion of the reagent raw materials, and continuously rotating the external thread pipe 552 until the dividing line and the bottom surface of the transitional connection base plate 534 are positioned on the same plane;
step three: pouring all reagent raw materials into the air guide sleeve 2 connected with the corresponding flow regulating mechanism 5 respectively, and rotating the rotary regulating seat 54 downwards until the drainage conduit 553 passes through the plane of the positioning connecting plate 61;
step four: all the reagent raw materials sequentially pass through the air guide sleeve 2, the air guide connecting mechanism 3, the connecting hose 4 and the flow regulating mechanism 5 and are mixed and stored in the mixing barrel 9 to form a reagent raw material mixed solution;
step five: then, sequentially opening the driving motor 63 and the telescopic oil cylinder, and closing the telescopic oil cylinder when the stirring mechanism 7 is completely immersed in the reagent raw material mixed liquid;
step six: and stirring the mixed solution of the raw materials of the reagent according to the preset time to finally form a finished product reagent.
Through scientific and reasonable structural design, the device not only can quickly modulate and fully react the pharmaceutical reagent, but also can quickly disassemble and install, ensures the sufficiency of the pharmaceutical reaction and the accuracy of test data in the modulating process through the structural design of the stirring mechanism, has high automation degree, simple structure and convenient use, can be quickly cleaned when in use or after in use, greatly improves the clinical work efficiency, and has good practical and popularization values.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (9)
1. A clinical pharmacy agent preparation device, comprising: the device comprises a mounting support (1) and air guide hoods (2) uniformly distributed on the edge of the top of the mounting support (1), wherein the bottom end of each air guide hood (2) is vertically connected with a flow guide connecting mechanism (3), the bottom ends of the flow guide connecting mechanisms (3) are connected with a flow regulating mechanism (5) through connecting hoses (4), the bottom of each flow regulating mechanism (5) is connected with a positioning connecting seat (6), the center of the bottom of each positioning connecting seat (6) is provided with a stirring mechanism (7), the center of the top of each positioning connecting seat (6) is connected with the top end of the mounting support (1) through a lifting connecting seat (8), and the center of the bottom of the mounting support (1);
the mounting support (1) comprises an annular mounting seat (11) and supporting columns (12) uniformly distributed at the bottom edge of the annular mounting seat (11), supporting connecting rods (13) are uniformly distributed at the surface edge of the annular mounting seat (11), a supporting top plate (14) is horizontally mounted at the top end of each supporting connecting rod (13), mounting jacks (15) are uniformly distributed at the surface edge of each supporting top plate (14), a guide sleeve (16) is arranged in the center of the bottom surface of each supporting top plate (14), and four limiting slots (17) are uniformly distributed at the periphery of the annular mounting seat (11);
the lifting connecting seat (8) comprises a lifting connecting plate (81), lifting connecting rods (83) fixedly connected with the positioning connecting seat (6) are uniformly distributed on the edge of the bottom of the lifting connecting plate (81), and a sliding connecting cylinder (82) in sliding connection with the guide sleeve (16) is vertically arranged in the center of the surface of the lifting connecting plate (81); a telescopic oil cylinder is vertically arranged in the guide sleeve (16), the top end of the telescopic oil cylinder is fixedly connected with the supporting top plate (14), and the bottom end of the telescopic oil cylinder is fixedly connected with the lifting connecting plate (81); the positioning connecting seat (6) comprises a positioning connecting plate (61), internal thread sleeves (62) are uniformly distributed on the edge of the surface of the positioning connecting plate (61), a driving motor (63) is vertically arranged in the center of the positioning connecting plate (61), and a protective housing (64) is arranged outside the driving motor (63);
the flow guide connecting mechanism (3) comprises a flow guide support (31) and a flow guide connecting pipe (32) which are installed in a matched mode, the flow guide support (31) comprises a flow guide vertical plate (311) which is vertically fixed on the bottom surface of a supporting top plate (14), a clamping bottom plate (312) is vertically arranged at the bottom of the flow guide vertical plate (311), a clamping hole (313) is formed in the center of the clamping bottom plate (312), two elastic clamping strips (314) which are horizontally distributed are symmetrically arranged in the middle of the flow guide vertical plate (311), and arc-shaped clamping grooves (315) matched with the flow guide connecting pipe (32) are formed in the inner side surface of; a switch valve (322) is arranged in the middle of the flow guide connecting pipe (32), and a conical flow guide cylinder (321) with a wide upper part and a narrow lower part is arranged at the bottom end of the flow guide connecting pipe (32);
the flow regulating mechanism (5) comprises a drainage connecting piece (51), a confluence mechanism (52), a transition connecting seat (53) and a rotary regulating seat (54) which are sequentially arranged from top to bottom, and a drainage connecting piece (55) is vertically arranged in the middle of the transition connecting seat (53);
the rotary adjusting seat (54) comprises an external thread sleeve (542) matched with the internal thread sleeve (62), and the top end of the external thread sleeve (542) is provided with an annular bulge (541); the drainage connector (55) comprises a rotary mounting block (551), a drainage conduit (553) is arranged at the center of the bottom surface of the rotary mounting block (551), and an external threaded pipe (552) is arranged at the center of the top surface of the rotary mounting block (551);
the confluence mechanism (52) comprises three confluence assembly parts (521) which are uniformly distributed along the circumferential direction, and two adjacent confluence assembly parts (521) are connected through a limiting plug-in (522);
the confluence assembly part (521) comprises an arc-shaped vertical plate (5211) with a section being a one-third circular ring, a first arc-shaped connecting block (5212) is vertically arranged in the center of the top surface of the arc-shaped vertical plate (5211), a second arc-shaped connecting block (5213) is vertically arranged in the center of the bottom surface of the arc-shaped vertical plate (5211), limiting grooves (5215) are uniformly distributed in the vertical direction on the left end surface of the arc-shaped vertical plate (5211), a first limiting clamping groove (5216) is vertically arranged in the center of the left end surface of the arc-shaped vertical plate (5211), limiting protrusions (5217) are uniformly distributed in the vertical direction on the right end surface of the arc-shaped vertical plate (5211), a second limiting clamping groove (5218) is vertically arranged in the center of the right end surface; the outer surfaces of the three first arc-shaped connecting blocks (5212) form first external threads together, and the outer surfaces of the three second arc-shaped connecting blocks (5213) form second external threads together;
the limit plug-in (522) comprises a first limit clamping strip (5221) and a second limit clamping strip (5222) which are connected with each other; interference fit is respectively formed between the first limiting clamping strip (5221) and the first limiting clamping groove (5216) and between the second limiting clamping strip (5222) and the second limiting clamping groove (5218);
the transition connecting seat (53) comprises a transition connecting cylinder (531) matched with the second external thread and a transition connecting bulge (532) arranged at the top end of the transition connecting cylinder (531), the bottom of the transition connecting cylinder (531) is provided with a transition connecting bottom plate (534), the top end of the inner side surface of the transition connecting cylinder (531) is provided with a first annular pressure stop plate (533), the center of the inner surface of the transition connecting bottom plate (534) is provided with a central boss (535), the center of the bottom surface of the central boss (535) is provided with an internal thread adjusting hole (536) matched with the external thread pipe (552), and the peripheral side of the internal thread adjusting hole (536) is uniformly provided with flow guide elongated slots (537) distributed along the axis;
the drainage connecting piece (51) comprises a drainage connecting cylinder (511) matched with the first external thread, a second annular pressure stop plate (512) is arranged at the bottom end of the inner side face of the drainage connecting cylinder (511), a conical connecting pipe (513) is arranged at the top end of the drainage connecting cylinder (511), a drainage connecting head (514) is arranged at the top end of the conical connecting pipe (513), and the drainage connecting head (514) is communicated with the bottom end of the conical guide cylinder (321) through a connecting hose (4);
the bottom end of the flow guide cover (2) is provided with a flow guide insertion pipe (21), and the bottom end of the flow guide insertion pipe (21) penetrates through the installation insertion hole (15) to be communicated with a flow guide connecting pipe (32);
supporting connecting grooves (91) corresponding to the limiting inserting grooves (17) are uniformly distributed on the periphery of the top end of the mixing barrel (9), the limiting inserting grooves (17) are connected with the supporting connecting grooves (91) through limiting inserting blocks (92), and elastic limiting belts (10) are mounted at the outer ends of the limiting inserting blocks (92);
the stirring mechanism (7) comprises a stirring installation shaft (71) vertically fixed at the bottom end of the driving motor (63), rotary connecting pieces (72) are uniformly distributed on the outer side of the stirring installation shaft (71) along the axis direction, two reinforcing connecting rods (73) are symmetrically installed in the middle of each rotary connecting piece (72), and adjacent rotary connecting pieces (72) are connected through spiral stirring blades (74);
two rotating clamping grooves (711) are symmetrically arranged on the peripheral side of the stirring installation shaft (71), the rotating connecting piece (72) comprises a central connecting block (721) and rotating connecting strips (724) symmetrically arranged on two sides of the central connecting block (721), a stirring installation hole (722) matched with the stirring installation shaft (71) is arranged in the center of the central connecting block (721), rotating limiting protrusions (723) matched with the rotating clamping grooves (711) are symmetrically arranged on the peripheral side of the stirring installation hole (722), and a fixed connecting hole (725) matched with the reinforcing connecting rod (73) is arranged in the middle of each rotating connecting strip (724); spiral stirring leaf (74) include arc connection piece (741), and arc connection piece (741) both ends are equipped with first stationary blade (742) and second stationary blade (743) of vertical distribution respectively.
2. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: the inner diameter of the clamping hole (313) is larger than the outer diameter of the edge of the lower end of the conical guide cylinder (321) and smaller than the outer diameter of the edge of the upper end of the conical guide cylinder (321).
3. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: one of the rotary connecting strips (724) in the rotary connecting piece (72) is fixedly connected with the second fixing piece (743) of the spiral stirring blade (74) below the rotary connecting piece, and the other rotary connecting strip (724) in the rotary connecting piece (72) is fixedly connected with the first fixing piece (742) of the spiral stirring blade (74) above the rotary connecting piece.
4. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: the reinforcing connecting rod (73) is in interference fit with the fixed connecting hole (725).
5. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: the annular bulge (541) and the transition connecting bulge (532) are fixedly connected through bolts.
6. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: the lifting connecting rod (83) is connected with the positioning connecting plate (61) through welding.
7. The apparatus for preparing a clinical drug preparation according to claim 1, wherein: and a sealing baffle is horizontally arranged at the bottom end inside the internal thread sleeve (62) through a torsion spring.
8. A method for preparing a clinical drug preparation using the preparation apparatus according to claim 1, characterized in that: the modulation method comprises the following steps:
the method comprises the following steps: firstly, assembling a flow guide cover (2), a flow guide connecting mechanism (3), a connecting hose (4), a flow regulating mechanism (5), a positioning connecting seat (6), a stirring mechanism (7), a lifting connecting seat (8) and a mixing barrel (9) in sequence;
step two: opening the same number of switch valves (322) according to the number of the required reagent raw materials, and determining the discharge capacity of the flow regulating mechanism (5) according to the proportion of each reagent raw material;
step three: pouring all reagent raw materials into the air guide sleeve (2) connected with the corresponding flow regulating mechanism (5) respectively, and rotating the rotary regulating seat (54) downwards until the drainage conduit (553) passes through the plane of the positioning connecting plate (61);
step four: all the reagent raw materials sequentially pass through the diversion cover (2), the diversion connecting mechanism (3), the connecting hose (4) and the flow regulating mechanism (5) and are mixed and stored in the mixing barrel (9) to form a reagent raw material mixed solution;
step five: then, sequentially opening a driving motor (63) and a telescopic oil cylinder, and closing the telescopic oil cylinder when the stirring mechanism (7) is completely immersed in the reagent raw material mixed liquid;
step six: and stirring the mixed solution of the raw materials of the reagent according to the preset time to finally form a finished product reagent.
9. The method for preparing a clinical pharmaceutical agent according to claim 8, wherein: the specific steps of determining the displacement of the flow regulating mechanism (5) in the second step are as follows: slowly screwing the external threaded tube (552) into the internal threaded adjustment hole (536);
when the top end of the external threaded pipe (552) is level with the bottom end of the diversion long groove (537), a first scale mark is engraved at the intersection of the bottom surface of the transitional connection bottom plate (534) and the outer surface of the external threaded pipe (552);
when the top end of the external threaded pipe (552) is level with the top end of the diversion long groove (537), a second scale mark is engraved at the intersection of the bottom surface of the transitional connection bottom plate (534) and the outer surface of the external threaded pipe (552);
equally dividing lines are marked between the first scale mark and the second scale mark, and corresponding percentage numbers are marked sequentially from top to bottom according to the sequence from small to large;
determining a corresponding dividing line on the external thread pipe (552) according to the proportion of the reagent raw materials, and continuously rotating the external thread pipe (552) until the dividing line and the bottom surface of the transitional connection bottom plate (534) are positioned on the same plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811509973.2A CN109589905B (en) | 2018-12-11 | 2018-12-11 | Clinical pharmacy reagent preparation device and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811509973.2A CN109589905B (en) | 2018-12-11 | 2018-12-11 | Clinical pharmacy reagent preparation device and preparation method thereof |
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| CN109589905A CN109589905A (en) | 2019-04-09 |
| CN109589905B true CN109589905B (en) | 2020-09-18 |
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| CN207520926U (en) * | 2017-10-16 | 2018-06-22 | 成都敏硅科技有限公司 | A kind of integration reduction medicament mixing match device for soil pollution reparation |
| CN108636563A (en) * | 2018-06-20 | 2018-10-12 | 马鞍山久特新材料科技有限公司 | A kind of monocomponent polyurethane prepare in carbon black grinding device |
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