CN109568342A - Application of the ferroso-ferric oxide-silica-platinum nano-complex in antibiosis - Google Patents
Application of the ferroso-ferric oxide-silica-platinum nano-complex in antibiosis Download PDFInfo
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- CN109568342A CN109568342A CN201811217008.8A CN201811217008A CN109568342A CN 109568342 A CN109568342 A CN 109568342A CN 201811217008 A CN201811217008 A CN 201811217008A CN 109568342 A CN109568342 A CN 109568342A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The present invention provides ferroso-ferric oxide-silica-platinum nano-complex in the application of antibiosis, the application includes being incubated for ferroso-ferric oxide-silica-platinum nano-complex and bacterium and hydrogen peroxide jointly, ferroso-ferric oxide-silica-platinum nano-complex peroxynitrite decomposition hydrogen promotes reactive oxygen species in bacterium, cause bacterium division growth to be obstructed, inhibits bacterial growth purpose to reach.The present invention is incubated for jointly using ferroso-ferric oxide-silica-platinum nano-complex and bacterium and hydrogen peroxide, to achieve the purpose that inhibit bacterial growth, the application has given full play to ferroso-ferric oxide-silica-platinum nano-complex and hydrogen peroxide synergistic effect, so that antibacterial effect is significant, and cost is relatively low for platinum nano-complex for ferroso-ferric oxide-silica-, reducing hydrogen peroxide use improves biological safety simultaneously, has a good application prospect.
Description
Technical field
The present invention relates to novel nano-material field more particularly to a kind of ferroso-ferric oxide-silica-platinum are nano combined
Application of the object in antibiosis.
Background technique
With the deep development of nanosecond science and technology, single nano material is not able to satisfy the growing demand of people increasingly,
It needs to develop novel and multifunctional composite material, it is integrated to meet multiple use by the functional diversities of material.
Pathogenic microbes especially bacterium can cause a variety of communicable diseases of human and animal, cause huge economic damage
Lose, while also having seriously affected the life and health and quality of life of the mankind, thus the research in relation to antibiosis and apply for
Protecting the life and health of human and animal has extremely important practical significance and application value.
Currently, the abuse due to antibiotic causes continuing to bring out for antibody-resistant bacterium, the curative effect of antibiotic is made to have a greatly reduced quality.
Into the rear antibiotic epoch, nano material provides brand-new thinking visual angle, silver nano-grain, Jenner for the solution of this problem
Rice grain, zinc oxide, titanium dioxide, carbon nanomaterial, graphene, certain compounds etc. all have antibacterial activity, display cashier
Broad prospect of application of the rice material in antibacterial field.But above-mentioned nano anti-biotic material or higher cost or biological safety are commented
Valence is not perfect or antibacterial effect is not ideal enough.
Ferroso-ferric oxide-silica-platinum nano-complex is that four oxygen of coated with silica is supported on by Pt nanoparticle
Change three-iron particle surface to be formed, there is magnetic and high-specific surface area.The present invention is intended to provide ferroso-ferric oxide-silica-
Application of the platinum nano-complex in antibiosis.
Summary of the invention
In view of the problems of the existing technology, the present invention provides ferroso-ferric oxide-silica-platinum nano-complex anti-
Application in terms of bacterium.
The present invention provides ferroso-ferric oxide-silica-platinum nano-complex in the application of antibiosis, including by four oxygen
Change three-iron-silica-platinum nano-complex and bacterium and hydrogen peroxide is incubated for jointly, inhibits bacterial growth to reach
Purpose.
The structure of the ferroso-ferric oxide-silica-platinum nano-complex is using ferriferrous oxide particles as core
Core-shell structure, the ferriferrous oxide particles have platinum nanometer by coated with silica, in the load of coated with silica layer surface
Grain, it is whole negatively charged, there is Mimetic enzyme activity.
Preferably, the particle of the ferroso-ferric oxide-silica-platinum nano-complex is in unitary core, particle size
For 30~50nm, wherein ferriferrous oxide particles size is 10~20nm, and silicon dioxide layer thickness is 5~10nm, platinum nanometer
Grain size be 2~3nm, can monodisperse in water phase.
Preferably, the preparation method of the ferroso-ferric oxide-silica-platinum nano-complex includes: using reversed micro-
Ferroso-ferric oxide in organic phase is carried out coated with silica by newborn method, and ferroso-ferric oxide-silica dioxide granule is prepared；So
Amination modification is carried out to the ferroso-ferric oxide-silica dioxide granule afterwards, keeps its surface positively charged；Finally by Pt nanoparticle
It is supported on the positively charged ferroso-ferric oxide-silica particles.
In above-mentioned technical proposal, ferroferric oxide nano granules and Pt nanoparticle all have peroxynitrite decomposition hydrogen and are produced from
By the characteristic of base, the two is compound to have synergistic effect, by ferroso-ferric oxide-silica-platinum nano-complex and pathogenic thin
Bacterium and hydrogen peroxide are incubated for jointly, be can decompose hydrogen peroxide and are generated a large amount of active oxygen radicals, are had to pathogenic bacteria dense
Spend the fragmentation effect that gradient relies on, and be obviously improved reactive oxygen species in bacterium, bacterium division growth is caused to be obstructed, growth by
Inhibit to obvious.
Preferably, the time being incubated for jointly is 0.5~3h.
Preferably, the temperature being incubated for jointly is 25~37 DEG C.
Preferably, the concentration of the bacterium is 1*10^4cfu/mL~1*10^8cfu/mL, the ferroso-ferric oxide-dioxy
SiClx-platinum nano-complex final concentration of 10~100 μ g/mL, final concentration of 100~300 μM of the hydrogen peroxide.When each
Material concentration within the above range when, fungistatic effect is more preferable.
Preferably, the bacterium is one of Gram-negative bacteria and gram-positive bacteria or a variety of.
Preferably, above-mentioned application is more significant for the bacteriostasis of Escherichia coli and staphylococcus aureus, therefore, institute
Stating bacterium is Escherichia coli and/or staphylococcus aureus.
Preferably, concrete application method be first by ferroso-ferric oxide-silica-platinum nano-complex and hydrogen peroxide with
Mass ratio 1~10:0.3~1 is configured to bacteriostatic agent, then puts into the bacteriostatic agent containing in germy process object,
0.5~3h is handled at 25~37 DEG C.
The present invention also provides a kind of bacteriostatic agents, including ferroso-ferric oxide-silica-platinum nano-complex and peroxidating
Hydrogen.The bacteriostatic agent matching while using, fungistatic effect are preferable.
Preferably, the mass ratio of the ferroso-ferric oxide-silica-platinum nano-complex and the hydrogen peroxide is 1
~10:0.3~1.
The present invention is incubated for jointly using ferroso-ferric oxide-silica-platinum nano-complex and bacterium and hydrogen peroxide,
To achieve the purpose that inhibit bacterial growth.The application given full play to ferroso-ferric oxide-silica-platinum nano-complex with
The synergistic effect of hydrogen peroxide so that fungistatic effect is significant, and ferroso-ferric oxide-silica-platinum nano-complex cost compared with
It is low, while reducing hydrogen peroxide use and improving biological safety, it has a good application prospect.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is the present invention
Some embodiments for those of ordinary skill in the art without creative efforts, can also basis
These attached drawings obtain other attached drawings.
Fig. 1 is ferroso-ferric oxide-silica-platinum nano-complex TEM figure in the embodiment of the present invention 1；
Fig. 2 is golden yellow under different ferroso-ferric oxide-silica-platinum nano-complex concentration in the embodiment of the present invention 2
Color staphylococcus inhibitory effect applies plate result；
Fig. 3 is golden yellow under different ferroso-ferric oxide-silica-platinum nano-complex concentration in the embodiment of the present invention 2
Color staphylococcus survival results；
Fig. 4 is reactive oxygen species comparing result in the bacterial body of different experiments group in the embodiment of the present invention 2；
Fig. 5 is the large intestine in the embodiment of the present invention 3 under different ferroso-ferric oxide-silica-platinum nano-complex concentration
Bacillus survival results.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without creative efforts, shall fall within the protection scope of the present invention.
Embodiment 1
The present embodiment provides a kind of ferroso-ferric oxide-silica-platinum nano-complex, preparation method includes following step
It is rapid:
The ferroferric oxide nano granules (1mg/mL, 10mL) that first will be dispersed in hexamethylene are dispersed in by mechanical stirring
(wherein Triton X-100, just in 10mL Triton X-100 (Triton X-100)/n-hexyl alcohol/water mixed solution
Hexanol, water molar ratio are 1:2:6), Reverse microemulsion is formed, 200 μ L of ammonium hydroxide and 200 μ L of ethyl orthosilicate is then added, makes
Coated with silica layer is formed outside ferroferric oxide nano granules, by obtained ferroso-ferric oxide-silica dioxide granule (1mg/
ML, 5mL) it is mixed with 3- aminopropyl trimethoxy siloxane (APTMS, 200 μ L), it carries out amination and modifies 14 hours, make its table
Face is positively charged, by obtained positively charged ferroso-ferric oxide-silica dioxide granule (1mg/mL, 5mL) and electronegative platinum nanometer
Particle (1mg/mL, 2mL) hybrid reaction 14 hours, makes platinum grain be supported on ferroso-ferric oxide-dioxy by electrostatic adsorption
Silicon carbide particle surface is to get the ferroso-ferric oxide-silica-platinum nano-complex (Fe3O4@Si-Pt), TEM figure is as schemed
Shown in 1.
Fe obtained by the present embodiment3O4@Si-Pt is in unitary core, and particle size is 30~50nm, wherein ferroso-ferric oxide
Grain size be 10~20nm, silicon dioxide layer thickness be 10~20nm, Pt nanoparticle size be 2~3nm, can monodisperse in water
Xiang Zhong has Mimetic enzyme activity.
Embodiment 2
The present embodiment provides ferroso-ferric oxide-silica-platinum nano-complex antibiosis application.
1, ferroso-ferric oxide-silica-influence of the platinum nano-complex to Survival probability of bacteria
By the 1 gained ferroso-ferric oxide-silica-platinum nano-complex of embodiment of various concentration, (final concentration is respectively 0
μ g/mL, 20 μ g/mL, 40 μ g/mL and 60 μ g/mL) combine hydrogen peroxide (final concentration of 200 μM) and staphylococcus aureus
(106Cfu/mL, 1mL) it is incubated for jointly, after being incubated for 2 hours at 37 DEG C, 10 μ L is taken to apply plate, knot respectively from each group mixture
Fruit as shown in Fig. 2, and by statistics clump count calculate bacterium survival rate, as a result as shown in Figure 3.
2, reactive oxygen species detect in bacterial body
First by staphylococcus aureus (108Cfu/mL, 1mL) and the DCFH-DA fluorescence nano complex of 10 μ L 10mM incubate
It educates 1.5 hours, the unbonded fluorescence nano complex of centrifugation removal, is then distributed into four parallel pipes, every 100 μ L bacterium solution of pipe,
As four experimental groups, respectively negative control group, hydrogen peroxide group (final concentration of 100 μM of hydrogen peroxide), ferroso-ferric oxide-
Silica-platinum nano-complex group (the final concentration of 20 μ g/mL of ferroso-ferric oxide-silica-platinum nano-complex), four oxygen
Changing three-iron-silica-platinum nano-complex+hydrogen peroxide group, (ferroso-ferric oxide-silica-platinum nano-complex is dense eventually
Degree is 20 μ g/mL, final concentration of 100 μM of hydrogen peroxide).Every group is incubated for 2 hours at 37 DEG C respectively, then takes 100 μ L bacterium
Liquid surveys fluorescence intensity of the DCF at the 520nm under 488nm excitation by microplate reader, to calculate activated oxidized water in bacterial body
It is flat, as a result as shown in Figure 4.
Embodiment 3
The present embodiment provides ferroso-ferric oxide-silica-influence of the platinum nano-complex to Escherichia coli survival rate.
By the 1 gained ferroso-ferric oxide-silica-platinum nano-complex of embodiment of various concentration, (final concentration is respectively 0
μ g/mL, 20 μ g/mL, 40 μ g/mL and 60 μ g/mL) combine hydrogen peroxide (final concentration of 200 μM) and Escherichia coli (106cfu/
ML, 1mL) it is incubated for jointly, after being incubated for 2 hours at 37 DEG C, 10 μ L is taken to apply plate respectively from each group mixture, passes through and count bacterium
The survival rate that number calculates bacterium is fallen, as a result as shown in Figure 5.
Embodiment 4
The present embodiment provides a kind of bacteriostatic agents, including ferroso-ferric oxide-silica-platinum nano-complex and peroxidating
Hydrogen, the two mass ratio are 6:0.68, and ferroso-ferric oxide-silica-platinum nano-complex concentration is 600 μ g/mL.
In use, putting into the bacteriostatic agent containing in germy process object, in waste water, and four oxidations three are controlled
Final concentration of 10~100 μ g/mL of iron-silica-platinum nano-complex and final concentration of 100~300 μM of hydrogen peroxide, preferably
The final concentration of 60 μ g/mL of ferroso-ferric oxide-silica-platinum nano-complex and final concentration of 200 μM of hydrogen peroxide are controlled, so
2h is handled at 37 DEG C afterwards, achievees the purpose that inhibit bacterial growth.
Comparative example 1
When the offer of this comparative example is added without hydrogen peroxide, ferroso-ferric oxide-silica-platinum nano-complex deposits bacterium
The influence of motility rate.
By the 1 gained ferroso-ferric oxide-silica-platinum nano-complex of embodiment of various concentration, (final concentration is respectively 0
μ g/mL, 20 μ g/mL, 40 μ g/mL and 60 μ g/mL) and staphylococcus aureus (106Cfu/mL, 1mL) it is incubated for jointly, at 37 DEG C
After lower incubation 2 hours, 10 μ L is taken to apply plate respectively from each group mixture, as a result as shown in Fig. 2, and passing through statistics clump count meter
The survival rate of bacterium is calculated, as a result as shown in Figure 3.
From figures 2 and 3, it will be seen that when ferroso-ferric oxide-silica-platinum nano-complex concentration reaches 60 μ g/mL
When, S. aureus colonies number significantly reduces, and Survival probability of bacteria reduces, and complex concentration is 60 μ g/mL joint peroxidating
When hydrogen, fungistatic effect is more significant.From fig. 4, it can be seen that in ferroso-ferric oxide-silica-platinum nano-complex and peroxidating
Under hydrogen collective effect, reactive oxygen species are significantly higher than hydrogen peroxide group and ferroso-ferric oxide-silica-platinum nanometer in bacterial body
Compound group.Ferroso-ferric oxide-silica-platinum nano-complex joint hydrogen peroxide is to Escherichia coli as can be seen from Figure 5
Fungistatic effect is more significant.
In conclusion provided in an embodiment of the present invention utilize ferroso-ferric oxide-silica-platinum nano-complex and bacterium
And hydrogen peroxide is incubated for jointly, can effectively achieve the purpose that inhibit bacterial growth.The application has given full play to ferroso-ferric oxide-
Silica-platinum nano-complex and hydrogen peroxide synergistic effect, so that antibacterial effect is significant, and ferroso-ferric oxide-dioxy
Cost is relatively low for platinum nano-complex for SiClx-, while middle single use hydrogen peroxide antibacterial, the application can subtract compared with the prior art
Few hydrogen peroxide use has a good application prospect to improve biological safety.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. ferroso-ferric oxide-silica-platinum nano-complex is in the application of antibiosis.
2. application according to claim 1, which is characterized in that the ferroso-ferric oxide-silica-platinum nano-complex
Structure be using ferriferrous oxide particles as the core-shell structure of core, the ferriferrous oxide particles by coated with silica,
The load of coated with silica layer surface has Pt nanoparticle.
3. application according to claim 1 or 2, which is characterized in that the application includes by ferroso-ferric oxide-titanium dioxide
Silicon-platinum nano-complex and bacterium and hydrogen peroxide are incubated for jointly.
4. application according to claim 3, which is characterized in that the time being incubated for jointly is 0.5~3h.
5. application according to claim 3 or 4, which is characterized in that the temperature being incubated for jointly is 25~37 DEG C.
6. according to the described in any item applications of claim 3~5, which is characterized in that the concentration of the bacterium is 1*10^4cfu/
ML~1*10^8cfu/mL, final concentration of 10~100 μ g/mL of the ferroso-ferric oxide-silica-platinum nano-complex,
Final concentration of 100~300 μM of the hydrogen peroxide.
7. according to the described in any item applications of claim 3~6, which is characterized in that the bacterium is Gram-negative bacteria and leather
One of Lan Shi positive bacteria is a variety of；Preferably Escherichia coli and/or staphylococcus aureus.
8. application according to claim 1 or 2, which is characterized in that concrete application method is first by ferroso-ferric oxide-dioxy
SiClx-platinum nano-complex and hydrogen peroxide are configured to bacteriostatic agent with mass ratio 1~10:0.3~1, then by the bacteriostatic agent
It puts into containing in germy process object, 0.5~3h is handled at 25~37 DEG C.
9. a kind of bacteriostatic agent, which is characterized in that including ferroso-ferric oxide-silica-platinum nano-complex and hydrogen peroxide.
10. bacteriostatic agent according to claim 9, which is characterized in that the ferroso-ferric oxide-silica-platinum nanometer is multiple
The mass ratio for closing object and the hydrogen peroxide is 1~10:0.3~1.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233840A (en) * | 2015-09-08 | 2016-01-13 | 中国科学院苏州生物医学工程技术研究所 | Nano particle, and preparation method and application thereof |
| CN106619712A (en) * | 2016-12-20 | 2017-05-10 | 国家纳米科学中心 | Application of copper oxide-platinum nanocomposite in antibiosis |
| WO2017147623A1 (en) * | 2016-02-24 | 2017-08-31 | Green Nanotech Labs, Llc | A Method to Manufacture Carbon Fibers through Graphene Composites and the Use Thereof |
-
2018
- 2018-10-18 CN CN201811217008.8A patent/CN109568342A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233840A (en) * | 2015-09-08 | 2016-01-13 | 中国科学院苏州生物医学工程技术研究所 | Nano particle, and preparation method and application thereof |
| WO2017147623A1 (en) * | 2016-02-24 | 2017-08-31 | Green Nanotech Labs, Llc | A Method to Manufacture Carbon Fibers through Graphene Composites and the Use Thereof |
| CN106619712A (en) * | 2016-12-20 | 2017-05-10 | 国家纳米科学中心 | Application of copper oxide-platinum nanocomposite in antibiosis |
Non-Patent Citations (3)
| Title |
|---|
| CHONGWEN WANG ET AL: "Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents", 《INTERNATIONAL JOURNAL OF NANOMEDICINE》 * |
| HUACHAO ZAI ET AL.: "A novel hierachically-nanostructured Pt/SiO2/Fe3O4 catalyst with high activity and recyclability towards hydrosilylation", 《RSC ADVANCES》 * |
| 丁明洁等: "纳米四氧化三铁及其复合材料的性能研究进展", 《广东化工》 * |
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Application publication date: 20190405 |