CN109567982A - A kind of overlay film frame - Google Patents
A kind of overlay film frame Download PDFInfo
- Publication number
- CN109567982A CN109567982A CN201710962943.6A CN201710962943A CN109567982A CN 109567982 A CN109567982 A CN 109567982A CN 201710962943 A CN201710962943 A CN 201710962943A CN 109567982 A CN109567982 A CN 109567982A
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- CN
- China
- Prior art keywords
- overlay film
- micro
- nano
- hole
- film frame
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of overlay film frames, belong to biomedical engineering field；Including rack body and the overlay film that is set on the rack body, which is characterized in that using laser processing technology on the overlay film on some or all of outer surface for processing micro-nano hole and the overlay film being made to be fitted in the rack body；The positive effect of the present invention is: processing micro-nano hole or micro-nano structure using laser processing technology is some or all of on the overlay film, the presence of these micro-nano holes increases the surface area of covering material, increases degradation speed under environment in vivo；The progress of laser processing technology can control diameter and the distributed areas of micro-nano hole, can accurately control the depth of micro-nano hole, can both process through-hole, can also be with processing blind hole.
Description
Technical field
The present invention relates to a kind of overlay film frames, belong to biomedical engineering field.
Background technique
Common vascular diseases include the diseases such as aneurysm, angiorrhoxis, vascular puncture and hemadostewnosis.Aneurysm be by
In arterial blood tube wall because disease occurs, damage or congenital sexual factor make vascular wall thinning, under blood flow impact, weak blood vessel by
It gradually protrudes outward rounded, and then becomes aneurysm, it can vascular compression surrounding tissue organ.And aneurysm constantly grows and has
It may cause aneurysm angiorrhoxis, acute bleeding occur, cause life danger.
The advantages such as intravascular Interventional Treatment has small wound, few intercurrent disease, highly-safe, patient suffering is small, are increasingly becoming
Treat aneurysmal main method.Among these, overlay film frame method is a kind of common method.Overlay film frame method will be mainly in
The overlay film frame of compressive state is sent to vascular lesion position, after accurate positionin, is discharged, and the overlay film frame after expansion can cover
Lesion vessels completely cut off vascular lesion position and form new blood vessel access, so that aneurysm be made to lose blood supply, reach treatment
Purpose.
Overlay film frame can not achieve by overlay film physical isolation aneurysm to aneurysmal active treatment, cover simultaneously
Film non-degradable, causes overlay film to be permanently present, line artery endothelialization, thus, there are thrombotic risk, need to carry out long-term anti-blood
Platelet treatment.And overlay film has also blocked branch vessel when blocking the aneurysm of lesion vessels, and branch vessel internal organs is caused to lack
Blood is easy to induce patient's paraplegia or death etc..
The overlay film frame used in interventional therapeutic technique is the artificial blood vessel being adapted with vessel size, it is by overlay film and branch
Support the bracket composition of overlay film, bracket generally uses Nitinol, and overlay film uses high molecular material, have PET (polytetrafluoroethylene (PTFE)),
EPTFE (pet resin), terylene etc..This tunic can be medicine carrying membrane, can effective extending bracket
The effective use time, but existing overlay film largely be all it is nondegradable, endothelial cell can not be covered by overlay film
Metallic support, bracket in blood exposed in this way cause Thrombosis in sten and in-stent restenosis, and patient needs to grow
Phase takes antiplatelet drug and anticoagulant, increases the financial burden and pain of patient.To overcome overlay film nondegradable
Drawback is increasingly becoming mainstream using degradable overlay film.
The endothelialization speed of Medical rack is to cause a key factor of thrombosis and restenosis in Medical rack slowly.
Accomplish that quick endothelialization needs preferred covering material and optimization overlay film surface micro-structure.A kind of tool of Chinese patent
There is the degradable amphoteric ion polymer (publication number CN103467728A, publication date on December 25th, 2013) of Bioconjugate,
One kind is disclosed to be copolymerized by annulenones acetal monomer, active ester monomer and zwitterionic monomer.This kind of polymer has ester
Base, can be degradable；With amphoteric ion, there is excellent anticoagulant property and biocompatibility；With active ester, impart
The Bioconjugate of the polymer；The polymer combines the characteristic of three kinds of monomers, and composition ratio is controllable, has multi-functional
Property, it can be used as bio-medical material use.Chinese patent medical internal marmem frame coated by high-molecular film for penetration therapy and its
Processing method (authorization publication number CN1194776C, authorized announcement date on March 30th, 2005), disclose overlay film frame overlay film plus
Work method, the film are divided into inner membrance, outer membrane and microporous barrier.The manufacturing process for the overlay film that the patent provides is more complicated, the manufacturing cycle
It is longer.
It is a problem that covering material, which is controlled, in the intracorporal degradation time of people.
Summary of the invention
The purpose of the present invention is controlling covering material by optimization overlay film surface micro-structure in the intracorporal degradation time of people,
So that endothelial cell is covered metallic support by overlay film, reaches quick endothelialization.
To achieve the above object, the present invention provides a kind of overlay film frame, including rack body and it is set in the bracket
Overlay film on ontology, which is characterized in that process micro-nano hole using laser processing technology is some or all of on the overlay film
Hole is simultaneously fitted in the overlay film on the outer surface of the rack body.
Preferably, the micro-nano hole is through-hole, or is blind hole；Or a part of the micro-nano hole is through-hole,
Another part is blind hole.
Preferably, the diameter of the micro-nano hole is between 1.0-0.1 microns.
Preferably, the diameter of the micro-nano hole is 0.01 micron.
Preferably, the diameter of the micro-nano hole is 0.05 micron.
Preferably, micro-nano structure is processed on the overlay film, there are many micro-nano structures, such as square column array junctions
Structure, parallel grating structure, mastoid process structure and multi-level complicated heterogeneous structure.
The positive effect of the present invention is:
(1) some or all of on the overlay film using laser processing technology to process micro-nano hole, these micro-nano holes
The presence in hole increases the surface area of covering material, increases degradation speed under environment in vivo.
(2) micro-nano structure is processed using laser processing technology is some or all of on the overlay film, these micro-nano knots
The presence of structure increases the surface area of covering material, increases degradation speed under environment in vivo.
(3) progress of laser processing technology can control diameter and the distributed areas of micro-nano hole.
(4) progress of laser processing technology can accurately control the depth of micro-nano hole, can both process through-hole, can also
With processing blind hole.
Detailed description of the invention
Fig. 1 is the bare metal stent of the prior art.
Fig. 2 is a kind of overlay film frame of the prior art (overlay film is relatively thin).
Fig. 3 is a kind of overlay film frame of the prior art (overlay film is thicker).
Fig. 4 is a kind of micro-structure diagram of the overlay film of overlay film frame of the invention.
Fig. 5 is a kind of surface micro-nano structure of the overlay film of overlay film frame of the invention.
Appended drawing reference indicates are as follows: 1- rack body；2- overlay film；21- micro-nano hole.
Specific embodiment
The specific embodiment that the invention will now be described in detail with reference to the accompanying drawings.
Embodiment 1:
A kind of overlay film frame, including rack body 1 and the overlay film 2 being set on the rack body 1, which is characterized in that
It processes micro-nano hole 21 using laser processing technology is some or all of on the overlay film 2 and is fitted in the overlay film 2
On the outer surface of the rack body 1.
The overlay film uses PLGA degradation material.
Build laser-processing system.Firstly, laser has good same tone, it can be focused into directly with optical system
The luminous point (less than one micron) of diameter very pettiness, this is equivalent to the microbit for drilling.Secondly, the brightness of laser is very high,
Laser energy density (energy on average every square metre of area) in the focus of focusing can be very high, and a common laser is defeated
The energy of laser out, generation can be up to 109 joules/square centimeter, it is sufficient to allow material to melt and gasify, stay on material
Next aperture is like the micropore that drill bit drills out.
Using the laser-processing system built, 0.1 micron of diameter of micro-nano hole is processed on the overlay film 2.
The overlay film 2 is fitted on the outer surface of the rack body 1.
PLGA degradation material degradation in vivo was needed by two stages: corrosion and absorption.First in water environment,
PLGA overlay film surface is under the enzyme effect that microorganism or cell discharge, and ester bond hydrolyzes, and macromolecular chain, which is gradually broken, to be become
Low polymer loses original mechanical strength.When molecular weight is small arrives water-soluble limit (Mn=5000 or so), material
Material overall structure will deform and weightlessness, gradually becomes small fragment (water-soluble small molecule) and enters body fluid；Then
It is primary to decompose the low molecular weight intermediate product generated and gradually fall off dissolution, it is transformed into the cream of the contained simultaneously energy metabolism of organism itself
Acid, hydroxyacetic acid, ultimately generate the products such as carbon dioxide and water.
After processing 0.1 micron of diameter of micro-nano hole on the overlay film 2, the surface area of the overlay film is increased, is increased
The active area with enzyme is added, has accelerated the degradation of the overlay film, has accelerated the endothelialization speed of Medical rack, avoid medical
The generation of thrombus in stents.
Diameter and distributed areas by controlling micro-nano hole can be with by accurately controlling the depth of micro-nano hole
Control the degradation time of the overlay film.The degradation time of a certain medical macromolecular materials in vivo needs experimental verification.
The overlay film can use other degradable medical high molecular materials.
Embodiment 2:
A kind of overlay film frame, including rack body 1 and the overlay film 2 being set on the rack body 1, which is characterized in that
It processes micro-nano structure using laser processing technology is some or all of on the overlay film 2 and the overlay film 2 is made to be fitted in institute
On the outer surface for stating rack body 1.
The overlay film uses PLGA degradation material.
Many in the process that the overlay film surface processes micro-nano structure, one of method is: using nanosecond arteries and veins
Laser or continuous wave laser are rushed, laser multiple-beam interference system is built and generates interfering beam, the number of the interfering beam of generation
Mesh is 2~8 beams, or the interference light of more multi beam can be used for the processing of large area (range) surface.It should be noted that described
There are many micro-nano structures that overlay film surface processes, such as rectangular pillar array structure, parallel grating structure, mastoid process structure and more
Level complexity isomery rack surface etc., as shown in a~i in Fig. 5.A kind of micro-nano knot can be processed on the overlay film surface
Structure, can also the different location according to actual needs on the same overlay film surface process different micro-nano structures.
After processing micro-nano structure on the overlay film 2, the overlay film 2 is fitted in the outer surface of the rack body 1
On.
PLGA degradation material degradation in vivo was needed by two stages: corrosion and absorption.First in water environment,
PLGA overlay film surface is under the enzyme effect that microorganism or cell discharge, and ester bond hydrolyzes, and macromolecular chain, which is gradually broken, to be become
Low polymer loses original mechanical strength.When molecular weight is small arrives water-soluble limit (Mn=5000 or so), material
Material overall structure will deform and weightlessness, gradually becomes small fragment (water-soluble small molecule) and enters body fluid；Then
It is primary to decompose the low molecular weight intermediate product generated and gradually fall off dissolution, it is transformed into the cream of the contained simultaneously energy metabolism of organism itself
Acid, hydroxyacetic acid, ultimately generate the products such as carbon dioxide and water.
After processing micro-nano structure on the overlay film 2, the surface area of the overlay film is increased, increases the effect with enzyme
Area accelerates the degradation of the overlay film, accelerates the endothelialization speed of Medical rack, avoids the life of thrombus in Medical rack
At.
By way of controlling micro-nano structure and distributed areas, the degradation time of the overlay film can be accurately controlled.
The positive effect of the present invention is:
(1) some or all of on the overlay film using laser processing technology to process micro-nano hole, these micro-nano holes
The presence in hole increases the surface area of covering material, increases degradation speed under environment in vivo.
(2) micro-nano structure is processed using laser processing technology is some or all of on the overlay film, these micro-nano knots
The presence of structure increases the surface area of covering material, increases degradation speed under environment in vivo.
(3) progress of laser processing technology can control diameter and the distributed areas of micro-nano hole.
(4) progress of laser processing technology can accurately control the depth of micro-nano hole, can both process through-hole, can also
With processing blind hole.
Claims (6)
1. a kind of overlay film frame, including rack body and the overlay film being set on the rack body, which is characterized in that using sharp
Light processing technology is some or all of on the overlay film to be processed micro-nano hole and the overlay film is made to be fitted in the bracket sheet
On the outer surface of body.
2. overlay film frame according to claim 1, which is characterized in that the micro-nano hole is through-hole, or is blind hole；Or
A part of micro-nano hole described in person is through-hole, and another part is blind hole.
3. overlay film frame according to claim 1 or 2, which is characterized in that the diameter of the micro-nano hole is between 1.0-0.1
Between micron.
4. overlay film frame according to claim 1, which is characterized in that the diameter of the micro-nano hole is 0.01 micron.
5. overlay film frame according to claim 1, which is characterized in that the diameter of the micro-nano hole is 0.05 micron.
6. overlay film frame according to claim 1, which is characterized in that micro-nano structure is processed on the overlay film, it is described
There are many micro-nano structures, such as rectangular pillar array structure, parallel grating structure, mastoid process structure and multi-level complicated isomery knot
Structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710962943.6A CN109567982A (en) | 2017-09-28 | 2017-09-28 | A kind of overlay film frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710962943.6A CN109567982A (en) | 2017-09-28 | 2017-09-28 | A kind of overlay film frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109567982A true CN109567982A (en) | 2019-04-05 |
Family
ID=65919529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710962943.6A Pending CN109567982A (en) | 2017-09-28 | 2017-09-28 | A kind of overlay film frame |
Country Status (1)
| Country | Link |
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| CN (1) | CN109567982A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966012A (en) * | 2019-05-07 | 2019-07-05 | 吉林省一汽总医院 | A kind of overlay film and its overlay film frame with zigzag bonded structure |
-
2017
- 2017-09-28 CN CN201710962943.6A patent/CN109567982A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966012A (en) * | 2019-05-07 | 2019-07-05 | 吉林省一汽总医院 | A kind of overlay film and its overlay film frame with zigzag bonded structure |
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| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190405 |