CN109567935A - A kind of laser therapeutic system of combination tumour cell detection - Google Patents
A kind of laser therapeutic system of combination tumour cell detection Download PDFInfo
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- CN109567935A CN109567935A CN201811500315.7A CN201811500315A CN109567935A CN 109567935 A CN109567935 A CN 109567935A CN 201811500315 A CN201811500315 A CN 201811500315A CN 109567935 A CN109567935 A CN 109567935A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
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Abstract
The present invention provides a kind of laser therapeutic system of combination tumour cell detection, in laser therapy, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, realize the accurate mark to tumour cell, auxiliary doctor distinguishes normal tissue and tumour cell during surgery, realize the accurate processing to tumour cell, and this system realizes that minimally invasive insertion type is directly administered using endoscope, realize the accurate administration to target site, greatly improve detection accuracy, and pharmaceutical use is effectively reduced, reduce bad and immunological rejection.The present invention can provide the precise information of therapentic part for user, help to improve treatment accuracy, reduce error, also greatly facilitate user, improve the operating characteristics of laser therapeutic apparantus.
Description
Technical field
The present invention relates to a kind of laser therapeutic systems, more particularly to a kind of laser therapy system of combination tumour cell detection
System.
Background technique
In recent years, with the continuous development of laser technology, laser is in disease treatment field using more and more extensive.Using
Laser action is in human body and treats disease, is primarily referred to as the fuel factor using laser to biological tissue, inhales in the tissue of exposure
Heat is generated after receiving luminous energy, increase the temperature of organization internal, tissue is solidified, burn, cut off or is vaporized.Laser therapy tool
Have the advantage that bleeding is few or not bleeding；Surgical field of view is clear, and surgical quality is high；Without Mechanical Contact in art, so as to avoid connecing
The sexy dye of touching；Pain is light in art, and after-operation response is small.But there is also some limitations for laser therapy, such as, it is difficult to it is accurate to control
Especially in surgical operation, the accidental injury that be easy to cause except diseased region；Therapeutic effect can not be determined after the treatment；It is special
It is not that effective inspection and means of tracking are more a lack of for subcutaneous tissue and bodily lumen.Existing laser therapeutic apparantus passes through
Endoscope obtains the image information for the treatment of object in human body, and the image information that user obtains according to endoscope is defeated to laser
Power is set out.And the high energy pulse laser that laser generates passes through optical fiber again and is transferred into human body, until therapentic part.
But the therapentic part image that is obtained by endoscope of user can only be general the information for knowing therapentic part, can not be comprehensive
Grasp therapentic part information, can only according to endoscopic images and by personal experience set laser output power, especially
For the tumor resection of some vital tissue organs, only with being visually difficult to distinguish tumour cell and normal tissue.In addition,
In surgical operation, surgical field of view has suffered from the interference of operation residue such as blood, water etc., seriously affects the judgement of doctor.
CN104789207A discloses a kind of rare earth ion doped nano fluorophor of hydrophily, and rare earth upconversion nano crystal is glimmering
Luminescent material utilizes two-photon absorption property of the rare earth ion Yb3+ at 980nm, in the laser that wavelength is 980nm as exciting light
Under source excitation, the relatively short fluorescence of wavelength can be launched.But for exciting the near infrared light of upconverting fluorescent material to people
The penetration capacity of body tissue is limited, and upconverting fluorescent material luminous efficiency is low, when upper conversion nano fluorescent particles are gathered in depth
When layer tissue or organ, external excitation light source cannot excite intracorporal nanoparticle and obtain fluorescence signal.
CN108815537A discloses a kind of tumour cell targeting specific fluorescence probe and the preparation method and application thereof,
The part that fluorescence probe contains polypeptide complex and fluorescent molecule is connected to form；The polypeptide complex by target polypeptide, wear
Film peptide, the peptide containing binding groups and nuclear location peptide are formed by connecting in any order；The polypeptide complex passes through the bonding
Group and the fluorescent molecule are covalently attached；The fluorescent molecule is aggregation-induced emission compound.The fluorescence probe has target
To being positioned at high express alphaⅤβ3And/or CD13The tumour cell of albumen, and taken polypeptide, fluorescent molecule orientation are transferred to cell
It is interior, have many advantages, such as fluorescence imaging in core, good biocompatibility, low toxicity, the target to pathogenic sites such as tumours may be implemented
To combination and fluorescence imaging, it can also be used to pharmaceutical carrier.
Summary of the invention
To solve the above problems, the present invention provides a kind of laser therapeutic system of combination tumour cell detection, controlled in laser
In treatment, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, is realized to the accurate of tumour cell
Mark, auxiliary doctor distinguish normal tissue and tumour cell during surgery, realize the accurate processing to tumour cell, and this system
It realizes that minimally invasive insertion type is directly administered using endoscope, realizes the accurate administration to target site, greatly improve detection
Accuracy, and pharmaceutical use is effectively reduced, reduce bad and immunological rejection.The present invention can provide for user
The precise information of therapentic part helps to improve treatment accuracy, reduces error, also greatly facilitates user, improve
The operating characteristics of laser therapeutic apparantus.
The invention provides the following technical scheme:
A kind of laser therapeutic system of combination tumour cell detection, the system comprises based endoscopic imaging part and laser therapies
Part, the based endoscopic imaging part include visual light imaging part and fluorescent imaging moiety, and the fluorescent imaging moiety includes will
Tumour cell targeting specific fluorescence probe is applied to the drug delivery device of destination organization.
Preferably, the fluorescence probe includes polypeptide complex and fluorescent molecule, and the polypeptide complex passes through the key
It closes group and the fluorescent molecule is covalently attached.
The fluorescent molecule includes the centre of luminescence and clad；The centre of luminescence is rare earth upconversion nano crystal phosphor
Material；The clad contains azido group.
Preferably, the binding groups are alkynyl.
The laser therapy part includes laser light source, laser transmission fiber and laser probe, and what laser light source generated controls
Laser is treated to be emitted through laser probe.
Preferably, the laser therapy part uses thulium doped optical fiber laser source, and thulium doped optical fiber laser source generates 2 μm of laser,
Thulium-doped fiber laser is close with the absorption peak of water, has fabulous due to can provide wavelength in 2 μm or so of long wave laser generation
To tissue cutting and coagulating effectiveness, can be transmitted with ordinary optic fibre, be ideal surgical laser light source.
The fluorescent imaging moiety further includes near-infrared light source, and near infrared light is transmitted through optical fiber, for irradiating destination organization,
Activate the tumour cell targeting specific fluorescence probe.
Treating can be transmitted with 2 μm of laser, visible light, the near infrared light by same or different optical fiber of losing, institute
It states and loses optical fiber and enter inside of human body through endoscope.
Preferably, the dosed portions include endoscope-use syringe, and the endoscope-use syringe will be for that will include institute
The medicament for stating tumour cell targeting specific fluorescence probe is injected into the blood vessel on destination organization periphery.
The system also includes image display devices, for showing visible light and fluorescent image, described image display device
Visible light and fluorescent image can be shown simultaneously, fluorescent image can also be added on visible images, directly in visible light
Fluorescent spots are indicated on image.
Compared with prior art, beneficial effects of the present invention:
1, in laser therapy, the detection to tumour cell is realized using tumour cell targeting specific fluorescence probe, it is real
Now to the accurate mark of tumour cell, doctor is helped to distinguish normal tissue and tumour cell during surgery, realized to tumour cell
Accurate processing.
2, this system realizes that minimally invasive insertion type is directly administered using endoscope, realizes the accurate administration to target site,
Detection accuracy is greatly improved, and effectively reduces pharmaceutical use, reduces bad and immunological rejection.
3, the present invention has selected ligand and image forming material carrier of the preferable polypeptide of bio-compatibility as target, has target
The characteristic of more accurate position, good biocompatibility, low toxicity is demarcated, the introducing of cell-penetrating peptide is so that the delivery of image forming material is safer
Efficiently；Relative market similar product, the present invention is low in cost, is metabolized faster in targeting body.
4, polypeptide and rare earth upconversion nano crystal fluorescent material are used in combination, and small toxicity, chemical stability are high, light is stablized
Property it is good, fluorescent emission is high-efficient, accurate targeting to pathogenic sites such as tumours may be implemented and combine and fluorescence imaging.
Detailed description of the invention
Fig. 1 is laser therapeutic system overall construction drawing of the present invention；
In figure, 1- laser therapeutic system, 2- laser therapy part, 3- based endoscopic imaging part, 4- visual light imaging part, 5-
Fluorescent imaging moiety, 6- drug delivery device, 7- near-infrared light source.
Specific embodiment
In order to be more clear goal of the invention of the invention, technical solution and advantageous effects, with reference to embodiments,
The present invention will be described in further detail.It should be understood that embodiment described in this specification is just for the sake of explanation
The present invention, be not intended to limit the present invention, embodiment design parameter setting etc. can adaptation to local conditions make a choice and simultaneously to result
Without substantial effect.
Embodiment
As shown in Figure 1, the present invention provides a kind of laser therapeutic system 1 of combination tumour cell detection, the system 1 includes
Laser therapy part 2 and based endoscopic imaging part 3, the based endoscopic imaging part 3 include visual light imaging part 4 and fluorescence imaging portion
Divide 5, the fluorescent imaging moiety 5 includes the drug delivery device that tumour cell targeting specific fluorescence probe is applied to destination organization
6。
The fluorescence probe includes polypeptide complex and fluorescent molecule, the polypeptide complex by the binding groups with
The fluorescent molecule is covalently attached, and the polypeptide complex is using more described in patent document (publication number CN108815537A)
Peptide complexes.
The fluorescent molecule includes the centre of luminescence and clad；The centre of luminescence is rare earth upconversion nano crystal phosphor
Material；The clad contains azido group.
The binding groups are alkynyl.
The laser therapy part 2 includes laser light source, laser transmission fiber and laser probe, and what laser light source generated controls
Laser is treated to be emitted through laser probe.
The laser therapy part 2 uses thulium doped optical fiber laser source, and thulium doped optical fiber laser source generates 2 μm of laser, mixes thulium light
Fibre laser is close with the absorption peak of water, has fabulous to people due to can provide wavelength in 2 μm or so of long wave laser generation
Body tissue cutting and coagulating effectiveness, can be transmitted with ordinary optic fibre, be ideal surgical laser light source.
The fluorescent imaging moiety 5 further includes near-infrared light source 7, and near infrared light is transmitted through optical fiber, for irradiating target group
It knits, activates the tumour cell targeting specific fluorescence probe.
Treating can be transmitted with 2 μm of laser, visible light, the near infrared light by same or different optical fiber of losing, institute
It states and loses optical fiber and enter inside of human body through endoscope.
The dosed portions 6 include endoscope-use syringe, and the endoscope-use syringe will be for that will include the tumour
The medicament of cell-targeting specificity fluorescence probe is injected into the blood vessel on destination organization periphery.
The system also includes image display devices, for showing visible light and fluorescent image, described image display device
Visible light and fluorescent image can be shown simultaneously, fluorescent image can also be added on visible images, directly in visible light
Fluorescent spots are indicated on image.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (9)
1. a kind of laser therapeutic system of combination tumour cell detection, which is characterized in that the system comprises based endoscopic imaging parts
And laser therapy part, the based endoscopic imaging part include visual light imaging part and fluorescent imaging moiety, the fluorescence imaging
Part includes the drug delivery device that tumour cell targeting specific fluorescence probe is applied to destination organization.
2. laser therapeutic system according to claim 1, which is characterized in that the fluorescence probe include polypeptide complex and
Fluorescent molecule, the polypeptide complex are covalently attached by the binding groups and the fluorescent molecule.
3. laser therapeutic system according to claim 2, which is characterized in that the binding groups are alkynyl.
4. laser therapeutic system according to claim 1, which is characterized in that the fluorescent molecule includes the centre of luminescence and packet
Coating；The centre of luminescence is rare earth upconversion nano crystal fluorescent material；The clad contains azido group.
5. laser therapeutic system according to claim 1, which is characterized in that the laser therapy part includes laser light
Source, laser transmission fiber and laser probe, the treatment laser that laser light source generates are emitted through laser probe.
6. laser therapeutic system according to claim 1, which is characterized in that the laser therapy part uses thulium doped fiber
Laser source.
7. laser therapeutic system according to claim 1, which is characterized in that the fluorescent imaging moiety further includes near-infrared
Light source.
8. laser therapeutic system according to claim 1, which is characterized in that the dosed portions include endoscope-use injection
Device.
9. laser therapeutic system according to claim 1, which is characterized in that the system also includes image display device,
For showing visible light and fluorescent image.
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| CN201811500315.7A CN109567935A (en) | 2018-12-07 | 2018-12-07 | A kind of laser therapeutic system of combination tumour cell detection |
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| CN201811500315.7A CN109567935A (en) | 2018-12-07 | 2018-12-07 | A kind of laser therapeutic system of combination tumour cell detection |
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Cited By (3)
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| CN110772318A (en) * | 2019-11-06 | 2020-02-11 | 刁冬梅 | Tumor surgical resection system |
| CN111557676A (en) * | 2020-05-13 | 2020-08-21 | 山东省肿瘤防治研究院（山东省肿瘤医院） | System and equipment for dynamically adjusting target area position according to change of tumor in radiotherapy process |
| CN113616330A (en) * | 2021-08-30 | 2021-11-09 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
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| CN111557676B (en) * | 2020-05-13 | 2023-12-19 | 山东省肿瘤防治研究院（山东省肿瘤医院） | System and equipment for dynamically adjusting target area position by tumor change in radiotherapy process |
| CN113616330A (en) * | 2021-08-30 | 2021-11-09 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
| CN113616330B (en) * | 2021-08-30 | 2023-03-14 | 河南大学第一附属医院 | Laser intervention operation system for cutting tumor tissue |
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