CN109554461B - The biomarker and its detection kit of one group of detection primary Hemophagocytic Lymphohistiocytosis - Google Patents

Abstract

The present invention provides the biomarkers and its detection kit of one group of detection primary HLH, are related to technical field of molecular biology.The biomarker for detecting primary HLH is mutated gene group, set including PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, CD27, MAGT1, RAB27A, LYST, AP3B1, BLOC1S6, TCN2, IL2RG mutated gene of totally 15 genes, exon region carry 411 mutational sites altogether.Detection primary HLH kit includes the primer for expanding mutated gene in the mutated gene group of primary HLH.The kit has many advantages, such as that detection efficiency height, mutated gene broad covered area, recall rate are high, and it is more accurate, authoritative to interpret report using medicine given by the detection kit.

Description

The biomarker of one group of detection primary Hemophagocytic Lymphohistiocytosis And its detection kit

Technical field

The present invention relates to technical field of molecular biology, and in particular to biomarker-mutation of one group of detection primary HLH Gene group and its detection kit.

Background technique

Hemophagocytic syndrome (hemophagocytic syndrome, HPS) is also known as Hemophagocytic lymphocyte Hyperplasia disease (hemophagocytic lymphohistiocytosis, HLH) is a kind of blood of rapid, high case fatality rate that is in progress System critical illness, is divided into primary and secondary two class, and different types of HLH therapeutic strategy and lapsing to has differences.It is clinical It is mainly shown as persistent fever, hepatosplenomegaly, laboratory checks that feature is whole blood trace elements, triglycerides (triglyceride, TG) and serum ferritin (serum ferritin, SF) increase, fibrinogen (fibrinogen, FIB it) reduces, can find phage-displayed peptide phenomenon at positions such as marrow, spleen, lymph nodes, serious patient can be fatal.According to disease Cause divides HLH for primary HLH (primary hemophagocytic lymphohistiocytosis, pHLH) and secondary Property HLH (secondary hemophagocytic lymphohistiocytosis, sHLH) two class.PHLH patient is due to coding The gene defect for participating in certain protein of above-mentioned immune response process, lead to the cytotoxicity defect of CTL and NK cell and Morbidity.SHLH can be caused by a variety of pathogenic factors, according to cause of disease difference can be divided into infection correlation HLH (including bacterium, fungi, The infection such as virus, protozoon), malignancy-associated HLH (including malignant lymphoma, leukaemia etc.) and autoimmunity disease correlation HLH (including juvenile idiopathic arthritis, Still disease) etc..

Current specific pHLH related gene include PRF1, UNC13D, STX11, STXBP2, LYST, RAB27A, AP3B1, SH2D1A, XIAP etc..Lian Hongyun etc. (2013) is in " children's Hemophagocytic Lymphohistiocytosis UNC13D base Because of Mutation Screening and clinical meaning " in disclose using direct Sequencing method in conjunction with round pcr, to 34 HLH infant UNC13D Gene extron code area carries out Mutation Screening, it was found that p.R256X, p.P374T, p.I410L and p.A397T mutation.Yuan Yuan (2013) mutation of UNC13D gene is disclosed in " UNC13D the and STX11 gene studies of hemophagocytic syndrome in children " Have: the mutation of p.R414L, p.I410L, p.R682G, p.K867E, p.R921H etc., STX11 gene have: p.R49Q etc..At present Disclosed pHLH related gene and mutational site are less, and detection covering surface when for gene diagnosis is small, and verification and measurement ratio is low.

The diagnosis of HLH is mainly lacked according to HLH diagnosis guide (2004), clinical manifestation and laboratory inspection item at present Weary specificity, therefore clinically more difficult identification pHLH and sHLH.Parent is consanguineous marriage or has specific family history to facilitate pHLH Diagnosis, 70%~80% pHLH falls ill within 1 years old, therefore age of onset has important prompt to anticipate the diagnosis of pHLH Justice.In addition, certain Special Clinical Manifestations of pHLH also contribute to antidiastole.Flow cytometry can detect pHLH patient NK cell And the GAP-associated protein GAP of CTL is horizontal, such as perforin, SAP, XIAP and CD107a etc. facilitate antidiastole.Gene mutation analysis is The goldstandard of pHLH diagnosis, can detect that 30%~70% pHLH patient at present.Therefore, gene mutation, which is not detected, to arrange Except pHLH, reason may be still have current unknown gene or current detection set meal range can not yet cover it is all known Mutation.

The method of detection pHLH relates generally to cellular morphology, flow cyctometry and molecular biology etc., wherein molecular biosciences Experimental method mainly has nest-type PRC, generation sequencing etc..PCR method cannot intuitively obtain specific mutant nucleotide sequence, and one The generation method of sequencing is influenced by sequencing throughput, can not disposably detect whole exon regions of multiple genes.And two generations The detection method as a kind of high throughput is sequenced, disposably can accurately measure the exon sequence of multiple genes, make precisely to control Treatment is possibly realized.Since pHLH associated gene mutation site is numerous, and existing known mutational site is less, in order to make pHLH gene What is diagnosed is more comprehensive, and covering surface is wider, and providing more mutational sites and its detection kit becomes inevitable trend.

Summary of the invention

The purpose of the present invention is to provide the mutated gene group of one group of detection primary HLH and its detection kits, overcome Problems of the prior art, improve the accuracy of the diagnosis to primary HLH.

One aspect of the present invention provides the biomarker of one group of detection primary HLH, and the biomarker is mutation base Because of group, the mutated gene group include PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, CD27, The set of MAGT1, RAB27A, LYST, AP3B1, BLOC1S6, TCN2, IL2RG mutated gene of totally 15 genes.

Specifically, the exon region of the mutated gene carries 411 mutational sites altogether；

411 mutational sites are as shown in table 1:

Table 1: primary HLH mutated gene group

Another aspect of the present invention provides reagent of the biomarker in preparation detection primary HLH of primary HLH a kind of Application in box.

The kit includes the reagent for detecting 411 mutational sites described in claim 1.

Another aspect of the present invention additionally provides a kind of kit for detecting primary HLH, and the kit includes: to be used for Detect the reagent in 411 above-mentioned mutational sites.

The detection reagent includes as shown in table 2 for expanding the PCR primer in 411 above-mentioned mutational sites:

Table 2: the 411 mutational site the primers of detection primary HLH

The detection kit further includes the reagent that genomic DNA is made to the library for sequencing, this kind of reagent is Reagent commonly used in the art, as long as can satisfy requirement of the PCR amplification to genomic DNA quality.The reagent preparation Method is this field customary preparation methods, preferably commercially available, such as: the fast run-up library kit (Ion of DNA was sequenced in two generations Torrent), two generations sequencing rapid DNA is built library kit (Illumina), and NGS builds library kit (Illumina) etc..

The kit further includes being expanded for the reagent that two generations were sequenced using amplimer provided by the invention The individual chip length arrived is 275bp or so, in conjunction with two generation sequencing technologies, is able to detect in mutated gene group of the present invention Whole exon regions.

Wherein the reagent for the sequencing of two generations is reagent commonly used in the art, as long as can satisfy to gained sequence Column carry out the requirement of two generations sequencing.The preparation method of reagent thereof be this field customary preparation methods, it is preferably commercially available can , such as: two generation sequencing library quantification kits, sequencing kit etc..

The kit further includes dNTP solution, and archaeal dna polymerase is positive right for the reagent of isolated or purified nucleic acid According to and/or negative control.

Reagent for isolated or purified nucleic acid can be Backman magnetic bead.

Preferably, the positive control is the positive control of this field routine, preferably comprising of the present invention prominent Become the genomic DNA stock solution of mutant gene sequence or the matter comprising mutant gene sequence in corresponding mutated gene group in gene group Grain is used as positive control.

Preferably, the negative control is the negative control of this field routine, preferably confirmed derived from Healthy People Wild type gene group DNA sequence dna storing liquid not comprising mutant gene sequence.

Sample used is the tissue of test object, as long as the genomic DNA of test object can be extracted from detection sample ?.

Preferably, detection sample used be one or more of peripheral blood, marrow, solid tissue sample, more preferably Ground, detection sample are peripheral blood.

A kind of application method of kit of the present invention comprising following steps:

(1) it using peripheral blood, marrow or the solid tissue sample of detection kit of the present invention extracting test object, mentions Take genomic DNA；

(2) with multiple PCR primer to the exon of 15 primary HLH related genes described in invention in genomic DNA Region is expanded；

(3) library for the sequencing of Ion Torrent microarray dataset is made in the resulting segment of amplification in step (2)；

(4) gained DNA library in step (3) is sequenced, obtains lower machine data；

(5) bioinformatic analysis is carried out to the lower machine data in (4), is then interpreted using medicine unscrambling data library Make diagnosis.

Reagent used in the present invention and raw material can be obtained through commercial channels, for example, it is commercially available purchase or be commercially synthesized.

Compared with prior art, positive and beneficial effect of the invention is:

The mutated gene group of one group of detection primary HLH provided by the invention and its detection kit can be used for screening original Hair property HLH mutated gene group, in conjunction with high throughput sequencing technologies, may be implemented molecular biology level to primary HLH into Row diagnosis, making anticipation especially for the subsequent orientation treatment of disease and effect has special advantage.It is provided by the invention Detection kit has many advantages, such as that detection efficiency height, mutated gene broad covered area, recall rate are high, is given using the detection kit It is more accurate, authoritative that medicine out interprets report.

Specific embodiment

Below by specific embodiments of the present invention will be described in detail.In order to avoid excessive unnecessary details, It will not be described in detail in following embodiment to belonging to well known structure or function.In addition to being defined, institute in following embodiment Technical and scientific term has the identical meanings being commonly understood by with those skilled in the art of the invention.

The screening of 1 Chinese population primary HLH mutated gene group of embodiment

Material and method:

In blood disease hospital, the Chinese Academy of Medical Sciences and magnificent medical diagnosis center in November, 2017 of coordinating to 2018 8 In the patient of moon diagnosis, according to following standard, we carry out continuity and enter group (41).

Inclusion criteria are as follows: be diagnosed as the patient of HLH through clinical symptoms and laboratory inspection, and screen and need to carry out To carry out the case that auxiliary is confirmed whether it is HLH, the diagnostic result of 41 patients is as shown in table 3 for genetic test.

3 patient's diagnostic result list of table:

Collection 3mL peripheral blood in patients extraction genomic DNA is to be measured, which passes through Chinese Academy of Medical Sciences's blood disease hospital Ethics Committee's approval.

1. sample process: genome (is purchased from Tiangeng biochemical technology Co., Ltd, goods using DNA extraction kit in sample Number: DP318-03) be stripped, concrete operation method referring to kit operation instructions.

2. the building in library: choose testing gene PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, The exons coding district of CD27, MAGT1, RAB27A, LYST, AP3B1, BLOC1S6, TCN2 and IL2RG gene and flank Part of intron region, using Ion amplicon sequencing library building kit 2.0-LV96 (be purchased from Thermo Fisher company, Article No.: 4475345) multiple PCR method is carried out to genomic DNA and builds library, the specific steps are as follows:

(1) target area of PCR amplification genomic DNA: pure water is 1. added into DNA sample according to concentration and is diluted to 5ng/ μ l, including pool1 and pool2, establish reaction system respectively: 5X Ion AmpliSeq^TM2 μ l, 2X Ion of HiFi Mix AmpliSeq^TM3 μ l of Primer Pool 5 μ l, genomic DNA 5ng/ μ l, adds ddH₂It is 10 μ l that O, which is supplemented to total volume,；2. plus 1400rpm brief centrifugation is covered, MixMate 2000r 5s is mixed, and 1400rpm brief centrifugation carries out PCR, and reaction condition is as follows: Kinase, 99 DEG C of maintenance 2min, 99 DEG C of denaturation 15s, 60 DEG C of annealing/extension 4min, 17 circulations, 10 DEG C maintain.

(2) digestion: pool1 reaction solution is transferred in pool2-PCR pipe, the FuPa of 1.9 μ l is added by centrifugation PCR pipe Reagent is mixed after sealing, and centrifugation, soft be vortexed are centrifuged again, and endonuclease reaction condition is as follows: 50 DEG C, 55 DEG C, and 60 DEG C of each reactions 20min；10 DEG C of reaction 1h.

(3) it expands effective library: 1. dissolving Switch Sloution, respective volume is added into each digestion products The Switch Solution and Barcode diluted, component are as follows: 22 μ l, Switch Solution of digestion products, 4 μ l, 2 μ l of Barcode, 28 μ l of total volume；2. the DNA ligase of 2 μ l is added in every hole, reaction condition is as follows after mixing: 22 DEG C of reactions 30min, 72 DEG C of reactions 10min, 10 DEG C of reaction 1h.

(4) purify the library not expanded: 1. 45 μ l AMPure Beads, vortex 5min are added in every hole in DNA library (1800rpm) is placed at room temperature for 5min, moves to experimental plate on magnetic frame after centrifugation, puts to clarifying and then discarding supernatant, is added The alcohol of 150 μ l fresh 70%, rotation Ep pipe two enclose or move left and right 96 orifice plates, discard alcohol；2. air-drying magnetic after coming again Pearl；EP pipe is removed, the Low TE that 100 μ l are added disperses magnetic bead, and soft be vortexed mixes；3. being placed at room temperature for 2min to move back to magnetic frame On, library is shifted after clarifying into clean EP pipe.

3. prepared by template: specific to walk with reference to the operation instructions of Ion Torrent sequenator corollary equipment One Touch It is rapid as follows:

(1) it dilutes library and quantifies: being 1. centrifuged the library gradient dilution built up after sufficient vortex to 200 times；2. standard 10 times of gradient dilutions of product are to 6.8pM, 0.68pM, 0.068pM, 7500 instrument of ABI, Ion AmpliSeq^TMDNA library reactant It is as follows: 2 × Master Mix 5 μ l, 20 × TaqMan 0.5 μ l, sample (standard items) 4.5 μ l, 10 μ of total volume；React item Part is as follows: 50 DEG C of maintenances 2min, 95 DEG C of 2min, 95 DEG C of denaturation 15s, 60 DEG C of annealing/extension 1min, 40 recycle.

(2) Water-In-Oil PCR amplification: 1. the library sufficient vortex for being diluted to 200 times is mixed, reaction system is as follows: 2000 μ l, Ion P1 of Master Mix^TM120 μ l, Ion P1 of Enzyme Mix^TMIon Sphere^TM Particles 100μ L, water (180-x) μ l of nuclease free, the library x* μ l after dilution, 2400 μ l of total volume.Library applied sample amount is fixed according to qRT-PCR Amount result is calculated, and is adjusted in the total applied sample amount of 700~750pmol.2. selecting Proton:Ion PI^TMHi-Q^TMOT2 200Kit program runs Water-In-Oil PCR reaction；3. removing the Recovery Tube after Water-In-Oil PCR reaction, upper layer is discarded Microballon is resuspended in Recovery solution, prepares Melt-off solution, and system is as follows: 280 μ l, 1M NaOH of Tween solution, 40 μ l, 320 μ l of total volume.

(3) it enrichment with magnetic bead: is vortexedMyOne^TM130 μ L-Ion are added in Streptavidin C1Beads PI^TMMyOne^TMBeads Capture Solution is enriched with.

(4) corresponding dedicated 8 connecting leg of agent transfer ES 1. One touch and ES: is subjected to ES reaction, 8 platoon holes number It is as follows that 1-8 corresponds to reagent sequence: the positive ISP template of 100 μ l, 130 μ l-MyOne^TMBeads eluent, 300 μ l Ion PI^TMES Wash Solution, 300 μ l Ion PI^TMES Wash Solution, 300 μ l Ion PI^TMES Wash Solution, empty, 300 μ l-Melt-off solution are empty.2. 15500g is centrifuged the ISP 5min after ES, abandons supernatant and only stay 10 μ l weight Outstanding magnetic bead；Cleaning, 15500g are centrifuged 5min, abandon supernatant and leave and take 10 μ l resuspension magnetic bead, moisturizing to 100 μ l, pressure-vaccum mixes 10 times.

4. sequencing reaction: referring to high-flux sequence instrument Ion Torrent operation instructions, the specific steps are as follows: (1) make Standby sequencing sample: 1. vortex Ion PI^TMControl Ion Sphere^TMParticles 5s is centrifuged 2s, after adding 4 μ l to ES Soft to be vortexed in re-suspension liquid, 15500g is centrifuged 3min；2. discarding supernatant, 10 μ l are stayed, 15 μ l-Ion PITM are then added Annealing Buffer adds 20 μ l Sequencing Primer, soft to be vortexed, and is centrifuged 2s；Sequencing primer annealing is anti- It answers: 95 DEG C, 2min；37 DEG C, 2min；25 DEG C of maintenances；3. be centrifuged PCR pipe, be added 10 μ l Loading Buffer, mix and from The heart, totally 55 μ l；(2) washing of Ion-Proton sequenator, chlorine are washed and are initialized；(3) Loading chip；(4) machine is sequenced on.

5. bioinformatic analysis: using Ion Report software (v4.6, Thermo Fisher, Carlsbad, CA, USA) filter low-quality sequencing fragment, and by qualified sequencing fragment compare to the mankind with reference to genome hg19 (http: // Hgdownload.cse.ucsc.edu/downloads.html), using Torrent Variant Caller (v4.6.0.7) Subprogram detects mutational site, and software parameter uses the setting of default.This software has been optimized for processing Ion The distinctive type of error of Torrent microarray dataset.To the mutation found out include SNP and Indel using ANNOVAR (http: // Annovar.openbioinformatics.org/en/latest/) software is annotated, and notes content includes mutation in gene Position in group, associated gene, gene extron number, nucleotide level variation, corresponding protein level variation, and should Mutation is in dbSNP database (http://www.ncbi.nlm.nih.gov/snp/), thousand human genome databases 1000Genomes (http://www.1000genomes.org/), exon group integrated database ExAC (http: // ) and human mutation database HGMD (http://www.hgmd.cf.ac.uk/ exac.broadinstitute.org/ Ac/index.php the annotation in), PolyPhen (http://genetics.bwh.harvard.edu/pph2/) and SIFT (http://sift.jcvi.org/) function prediction result etc..

Further use following principle screening pathogenic mutation site: (1) according to genomic locations and type mutation where, Filter out the mutation not having an impact to protein product sequence；(2) 1000Genomes, ExAC03 and ESP6500 crowd are utilized Database annotates ratio of each mutation in crowd, is not considered as polymorphic site if ratio is less than or equal to 1%；(3) Human mutation database is retrieved, inquires whether a mutation has in HGMD database, ClinVar database and document It records, whether appears in the related diseases such as primary HLH；(4) protein function forecasting software PolyPhen-2 is utilized, SIFT and MutationTaster predicts whether the mutation influences protein function.

Its result judgement is broadly divided into following two situation: (1) being predicted as causing a disease or doubtful pathogenic site mutation detects Result include: 1. HGMD database clearly report harmful site relevant to the disease and meet 1000Genomes, At least two data-base recording of ExAC03 and ESP6500 demographic data library is not record less than or equal to 1% or；②ClinVar Database clearly reports relevant to the disease harmful or harmful site and may meet 1000Genomes, ExAC03 and At least two data-base recording of ESP6500 demographic data library is not record less than or equal to 1% or；It is clearly recorded 3. having in document Site, and notice that the unknown site mutation detection of (refer to above-mentioned table 1) (2) clinical meaning related to disease to be detected is tied Fruit: to clinical diagnosis or suspect the relevant gene mutation of diagnosis and meet protein function forecasting software PolyPhen-2, SIFT and MutationTaster predict the mutation at least two influence protein function and/or 1000Genomes, ExAC03 and At least two data-base recording of ESP6500 demographic data library be do not record less than or equal to 1% or, but the mutation it is pathogenic simultaneously It is indefinite.

6. statistical analysis: counting the ratio that each gene carries pathogenic mutation, filter out the highest gene of mutation rate, use Software be Excel.

7. medicine is interpreted: making molecular disease to the genic mutation type that bioinformatic analysis obtains with medicine unscrambling data library Reason diagnosis.Medicine unscrambling data library used is as follows:

(1) PRF1 gene pure known to or compound heterozygous mutations and familial Hemophagocytic Lymphohistiocytosis 2 types (FHL-2) are related.Familial Hemophagocytic Lymphohistiocytosis (FHL) is infant or children's early stage The recessive hereditary disease of the immune disorder of morbidity, accidental teenager and adult patients.Clinical manifestation is mainly height The multiple organ damages such as heat, hepatosplenomegaly, enlargement of lymph nodes, whole blood trace elements, blood coagulation disorders and central nervous system involvement, group Knitting and learning feature is histocyte/macrophage hyperplasia and activation, and companion bites blood phenomenon.FHL-2 is by perforin gene PRF1 mutation, perforin protein expression are abnormal, and are the current most common pathogenesis.

(2) UNC13D gene pure known to or compound heterozygous mutations and familial Hemophagocytic lymphocyte hyperplasia 3 type of disease (FHL-3) is related.Familial Hemophagocytic Lymphohistiocytosis (FHL) be infant or children early stage i.e. The recessive hereditary disease for the immune disorder that can be fallen ill, accidental teenager and adult patients.Clinical manifestation is mainly The multiple organ damages such as high fever, hepatosplenomegaly, enlargement of lymph nodes, whole blood trace elements, blood coagulation disorders and central nervous system involvement, Histologic characteristics are histocyte/macrophage hyperplasia and activation, and companion bites blood phenomenon.FHL-3 is due to Munc23-4 Protein coding gene UNC13D mutation, Munc23-4 albumen play a decisive role during cell toxicant particle goes out born of the same parents.

(3) STX11 gene pure known to or compound heterozygous mutations and familial Hemophagocytic lymphocyte hyperplasia 4 type of disease (FHL-4) is related.Familial Hemophagocytic Lymphohistiocytosis (FHL) be infant or children early stage i.e. The recessive hereditary disease for the immune disorder that can be fallen ill, accidental teenager and adult patients.Clinical manifestation is mainly The multiple organ damages such as high fever, hepatosplenomegaly, enlargement of lymph nodes, whole blood trace elements, blood coagulation disorders and central nervous system involvement, Histologic characteristics are histocyte/macrophage hyperplasia and activation, and companion bites blood phenomenon.FHL-4 is due to STX11 gene Mutation, STX11 gene encode synaptotagmin, play an important role in function operation in the cell.

(4) STXBP2 gene pure known to or compound heterozygous mutations and familial Hemophagocytic lymphocyte hyperplasia 5 type of disease (FHL-5) is related.Familial Hemophagocytic Lymphohistiocytosis (FHL) be infant or children early stage i.e. The recessive hereditary disease for the immune disorder that can be fallen ill, accidental teenager and adult patients.Clinical manifestation is mainly The multiple organ damages such as high fever, hepatosplenomegaly, enlargement of lymph nodes, whole blood trace elements, blood coagulation disorders and central nervous system involvement, Histologic characteristics are histocyte/macrophage hyperplasia and activation, and companion bites blood phenomenon.FHL-5 is due to STXBP2 base Because mutating, STXBP2 gene encodes Muncl8-2 protein function, is adjusting the process lifting of vesicle transport to target cell membrane It acts on.

(5) SH2D1A gene mutation known to is related with 1 type (XLP-1) of X linksystem lymphoproliferative syndrome.XLP suffers from Person often falls ill because infecting EBV, and main clinical manifestation has lethal infectious mononucleosis (fatal infectious Mononucleosis, FIM), B cell lymphoma, dysgammaglobulinemia, wherein FIM accounts for 50%, and B cell lymphoma accounts for 20%, dysgammaglobulinemia accounts for 30%, and alpastic anemia, vasculitis, Pulmonary lymphomatoid granulomatosiss etc. are rare XLP clinical manifestation.XLP-1 by coding lymph signal anakmetomeres GAP-associated protein GAP (SLAM-associated protein, SAP caused by SH2D1A gene mutation).

(6) XIAP gene mutation known to is related with 2 type (XLP-2) of X linksystem lymphoproliferative syndrome.XLP patient It often falls ill because infecting EBV, main clinical manifestation has lethal infectious mononucleosis (fatal infectious Mononucleosis, FIM), B cell lymphoma, dysgammaglobulinemia, wherein FIM accounts for 50%, and B cell lymphoma accounts for 20%, dysgammaglobulinemia accounts for 30%, and alpastic anemia, vasculitis, Pulmonary lymphomatoid granulomatosiss etc. are rare XLP clinical manifestation.XLP-2 is caused by the chain XIAP gene mutation for inhibiting albumen of coding X, and inflammation can also occur in patient Disease property enteropathy.

(7) ITK gene pure known to or compound heterozygous mutations are related with Epstein-Barr virus associated lymphoid hyperplasia syndrome. Epstein-Barr virus associated lymphoid hyperplasia syndrome is normal caused by encoding the ITK gene mutation of IL2 induced T lymphocyte kinases Autosomal recessive primary immunodeficiency syndrome.It is mainly shown as that early stage children's Epstein-Barr virus related immune is lacked of proper care, shows as lymph Tumor, lymphomatoid granulomatosis, phage-displayed peptide lymphohistocysis disease and hypogammag lobulinemia.Patient may also send out Raw autoimmune disease, such as autoimmune hemolytic anemia or kidney trouble etc..

(8) CD27 gene pure known to or compound heterozygous mutations are related with Lymphocytosis II type.Lymphocyte increases Raw disease II type is the autosomal recessive immunologic deficiency disease as caused by CD27 gene mutation, is mainly shown as duration EBV virus Mass formed by blood stasis, hypogammag lobulinemia, phage-displayed peptide lymphohistocysis disease and lymthoma.

(9) MAGT1 gene mutation known to lacks with the chain immune deficiency of X with magnesium to be had with ebv infection and tumour It closes.The chain immune deficiency of X lacks companion's ebv infection with magnesium and tumour is the MAGT1 base due to encoding magnesium transport protein 1 Because of X-linkage recessive disease caused by mutating.It is mainly shown as light-duty combined immunodeficiency, Epstein-Barr virus Load increases, the relevant lymphadenia of Epstein-Barr virus, and is often accompanied by splenomegaly, dysgammaglobulinemia and CD4/ Cd8 cell ratio is inverted.

(10) RAB27A gene pure known to or compound heterozygous mutations are related with 2 type of Griscelli syndrome. 2 type of Griscelli syndrome is the autosomal recessive inheritance as caused by the RAB27A gene mutation of one Small GTPases of coding Property disease.It is mainly shown as the pyogenic infection of skin and internal organs repeatedly；Pigment slightly declines, and is mainly shown as hair Change in silver gray；Nervous system is most common to show as epilepsy and parmlysis of cranial nerve, other performance include physiological reflex it is hyperfunction, Muscle tensility is hyperfunction, intracranial hypertension, growth and development retroversion, nystagmus, incoordination etc..2 type of Griscelli syndrome develops For the median age of HLH about at 3.5 years old, the performance of part infant nervous system can be used as its primary performance that HLH occurs.

(11) LYST gene pure known to or compound heterozygous mutations are related with Chediak-Higashi syndrome. Chediak-Higashi syndrome (CHS) is a kind of due to the caused often dye of lysosome transport associated regulatory genes LYST mutation Colour solid recessive inheritance primary immunodeficiency disease.Typical diagnostic characteristic is that occur widened lysosome and cytoplasm into the cell Grain.It is mainly presented with caused by immune deficiency bacterium infection repeatedly, often involves respiratory tract, skin etc.；In hair, skin, eyes Equal positions can have different degrees of hypopigmentation；Nervous system lesion, which is then mainly seen in, grows up into children are more rare, predominantly all Enclose neuropathy；Part infant can have slight hemorrhagic tendency；About 85% infant can enter accelerated period, show as HLH.

(12) AP3B1 gene pure known to or compound heterozygous mutations are related with Hermansky-pudlak syndrome 2. Hermansky-pudlak syndrome (HPS) is one of Tietze syndrome, clinically with eye skin albinism symptom, go out Waxy lipid accumulation triad is main feature in blood tendency and tissue.HPS2 type is coded product combination albumen composition 3 AP3B1 gene mutation caused by recessive hereditary disease.It is mainly shown as congenital Neutrophilic granulocytopenia, instead Multiple infection, frequently results in pulmonary fibrosis；Eye pigment decline；Hematostaxis or prolonged bleeding time；In addition more rare can There is inflammatory bowel disease, slight facial deformity (extends, nostril is leaned forward) in people, developmental lag, slight amentia etc., at present There are some patientss that HLH can occur, is to be mainly shown as hepatosplenomegaly, whole blood trace elements, height due to caused by after virus infection Triglyceride mass formed by blood stasis etc. is different from other kinds of main feature.This disease is easily diagnosed as Chediak-Higashi at the beginning Syndrome, the latter by low pigment, cycles of infection and into the cell there is huge particle characterized by, but in HPS2 type Patient cells There is no huge particulate matters.

(13) BLOC1S6 gene pure known to or compound heterozygous mutations are related with Hermansky-pudlak syndrome 9. Hermansky-pudlak syndrome is one of Tietze syndrome, is clinically inclined with eye skin albinism symptom, bleeding To with lipid accumulation triad waxy in tissue be main feature.HPS9 type is the BLOC1S6 gene due to encoding pale albumen Recessive hereditary disease caused by being mutated, Case report is less at present, and main clinical manifestation has thrombopenia And leukopenia, eye, skin albinism, nystagmus and skin infection repeatedly.Laboratory, which checks, can find NK cell Activation is abnormal.

(14) TCN2 gene pure known to or compound heterozygous mutations and vitamin B12 deficiency disease/TC II deficiency disease/cobalt amine Plain transport protein II Defect is related.TC II deficiency disease (Transcobalamin II deficiency) is a kind of due to compiling Autosomal recessive disease caused by the TCN2 gene mutation of code transcobalamin II is characterized in that infant period is developed Bad, macrocytic anemia and pancytopenia.Other features include methylmalonic aciduria, recurrent infection, vomiting And diarrhea.In addition there is only a few TC II deficiency disease patient that HLH occurs.Vitamin B12 treatment can improve clinical symptoms.

(15) IL2RG gene mutation is related with Reconstruction in Sever Combined Immunodeciency/moderate known to.Severe combined immunodeficiency It (SCID) is one group of heterologous disease, feature is that T and B cell developmental disorder, lymphocyte number are extremely reduced and body fluid and thin Born of the same parents' immune deficiency.The mutation of the IL2RG gene of -2 receptor y subunit of encoding Interleukin can lead to autosomal recessive.Patient Serious combined immunodeficiency can occur for infant period, there are lymphopenia, be easy to happen virus and fungi and Bacterium infection, lacks delayed type hypersensitivity, DTH, atrophy of thymus gland, and HLH occurs for only a few SCID patient.Other part IL2RG gene The patient of mutation can behave as the immune deficiency of moderate.

It is as shown in table 1 to the selection result of Chinese population primary HLH mutated gene group, primary HLH mutated gene group Including PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, CD27, MAGT1, RAB27A, LYST, AP3B1, The set of BLOC1S6, TCN2 and IL2RG mutated gene of totally 15 genes, exon region carry 411 mutation positions altogether Point can be used for detecting primary HLH.

Primer needed for embodiment 2 synthesizes detection kit

Design of primers: being directed to mutational site of the present invention, multiple needed for being expanded using Primer6.0 software design PCR primer, primer sequence are as shown in table 2.

Primer synthesis: designed primer is sent to Synesis Company and is synthesized.

Embodiment 3 detects clinic HLH patient's sample using kit described in embodiment 2

(1) peripheral blood for collecting 3mL patient described in embodiment 1 (is purchased from Tiangeng biochemistry section using DNA extraction kit Skill Co., Ltd, article No.: DP318-03) genomic DNA is extracted, mutated gene sequence in mutated gene group of the present invention will be included The genomic DNA stock solution of column will be derived from the confirmed genome not comprising mutant gene sequence of Healthy People as positive control DNA sequence dna storing liquid is as negative control；

(2) multiple PCR primer in the kit described in embodiment 2 expands genomic DNA, PCR amplification it is anti- It answers system and response procedures is conventional method in that art；

(3) the resulting segment of amplification in step (2) is surveyed using two generations sequencing Ion amplicon with the method in embodiment 1 Sequence library construction Kit 2.0-LV96 (is purchased from Thermo Fisher company, article No.: 4475345) is made for Ion The library of Torrent microarray dataset sequencing.

(4) with the method in embodiment 1 to gained DNA library in step (3) after Water-In-Oil is handled in Ion High-flux sequence is carried out on Torrent platform, obtains lower machine data；

(5) bioinformatic analysis is carried out to the lower machine data in (4), is then interpreted using medicine unscrambling data library Make diagnosis.The positive rate of 15 genes detected by 41 patients is as shown in table 4 below.

4 primary HLH related gene positive rate of table:

After counting the result shows that: in 41 HLH patients, 19 patients are diagnosed as sHLH, and 22 patients are diagnosed as pHLH.Gene mutation is not detected in sHLH, there are 11 patients to detect gene mutation in pHLH, wherein PRF1 gene mutation There are 4, UNC13D and STXBP2 gene mutation each 2, STX11, XIAP and ITK gene mutation each 1.It can be seen that using The method that the detection kit was sequenced using two generations can carry out auxiliary diagnosis to pHLH patient, can effectively with the area sHLH Point, have the characteristics that diagnosis quickly, accurately, contained much information.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

SEQUENCE LISTING

<110>coordinate magnificent medical diagnostic techniqu Co., Ltd for Tianjin

The biomarker of<120>one groups of detection primary Hemophagocytic Lymphohistiocytosis and its detection examination Agent box

<130> 2019.07.29

<160> 1136

<170> PatentIn version 3.5

<210> 1

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1

acacacacac aaaagctgtt gaaag 25

<210> 2

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 2

gtttcaacca agctacaaac attacctaaa 30

<210> 3

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 3

ctttatcaat gtgttttgaa aagcaggact 30

<210> 4

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 4

aagagacaca tgaacacatt agtaccata 29

<210> 5

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 5

tgcctgaaag attacatttg ttcaaacat 29

<210> 6

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 6

atgtgtagga atggattttg aggttgt 27

<210> 7

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 7

tatgatcact gcttgtccat ttttcca 27

<210> 8

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 8

ctgcagttat ttaacattgc ccatgatatt 30

<210> 9

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 9

ctgcagttat ttaacattgc ccatgatatt 30

<210> 10

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 10

tgagaagaat tgagcatgga ttttggta 28

<210> 11

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 11

cctgctgaat attatggatt aggcctt 27

<210> 12

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 12

tttgccagaa ctctaaatct ctgaatga 28

<210> 13

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 13

ccaatctaat accacgaggc tcat 24

<210> 14

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 14

caacctgcac aacatggtga aattattaa 29

<210> 15

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 15

tatgctctgt atatctttca ggaaagacca 30

<210> 16

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 16

gccaggataa tatacacagg taggttc 27

<210> 17

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 17

atttacctat tggattaaaa acatgcattt tca 33

<210> 18

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 18

ctcacgtgct gcttcatcg 19

<210> 19

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 19

gtggaagact gttcaacact tacct 25

<210> 20

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 20

gcctgagtaa gacctttgat gtagg 25

<210> 21

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 21

agcatttctg cagagttggg tta 23

<210> 22

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 22

gggagaagga aaatgaaaaa tctaaaactt 30

<210> 23

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 23

gatgaatgag tagaaagcat gctgttc 27

<210> 24

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 24

ccgtacaaga tttattaggc agcttattgt 30

<210> 25

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 25

atgttcaagt tcaaaatgaa agctaagca 29

<210> 26

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 26

gagtcaggcc tagaaaacaa aagaac 26

<210> 27

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 27

tcaagtatgc caggaatata gacaaacatc 30

<210> 28

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 28

cttttacctg tggccatgtc aga 23

<210> 29

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 29

tgctctgaag caaaggcttt gta 23

<210> 30

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 30

atgcagattg ctcaaggtct aaagtaat 28

<210> 31

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 31

tgttcatgtg ataatgaagt gatatgctga 30

<210> 32

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 32

aagaaaacaa agcaagatag aactcctct 29

<210> 33

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 33

cttactagac tagaatgtca tctgtttgca 30

<210> 34

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 34

tgaagatgat ctggtaaaac tgcagatatt 30

<210> 35

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 35

gaacccagaa tatgcatatt tatgtgcatt 30

<210> 36

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 36

gccactattc agactatagg cagatg 26

<210> 37

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 37

taaaaggtct tagctaaatt gggcttgt 28

<210> 38

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 38

tttctccaag tttgatggct gatct 25

<210> 39

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 39

aatttcttag ttgtcagtct tgtcccaa 28

<210> 40

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 40

cttggcaaat gaagccaaca tatca 25

<210> 41

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 41

cctgcatagg gtctctatag cca 23

<210> 42

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 42

gaagcttctg ctgacttatc accat 25

<210> 43

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 43

cttgcagaga ctatgctttt gtatttgg 28

<210> 44

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 44

ggaaatcttc ttccctacag cagtaag 27

<210> 45

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 45

cgcaacccaa acctttctcc t 21

<210> 46

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 46

cgtacgagaa ctagttttgt tccgt 25

<210> 47

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 47

tgctctttgg ttagcaaagc aaaaa 25

<210> 48

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 48

tgagaaaact gtgattggct ctgtt 25

<210> 49

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 49

agtgtcttga tcatagttgg atcagttg 28

<210> 50

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 50

gtagtgctta ctcaaagatg tttcattgg 29

<210> 51

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 51

gttctttaaa aatagtcctg tgtgccatt 29

<210> 52

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 52

gtgagcatca tgtaaagcta gaattaaagg 30

<210> 53

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 53

gatgactgaa gaggaagttg acaagt 26

<210> 54

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 54

aactgccatg acttgataat aagttgact 29

<210> 55

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 55

tagcactgta cacaaacctg aaattct 27

<210> 56

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 56

cggctgacaa tgtgattttt aaaagtagaa 30

<210> 57

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 57

gctatcctag agtcttccac tgctt 25

<210> 58

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 58

ttgagctctg attatgattg ttctctgtt 29

<210> 59

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 59

acataaaaag tgtacggtcc catgaa 26

<210> 60

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 60

cggttaatta cgtagcttat ttgttgacct 30

<210> 61

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 61

catattcaag tcatcttcac ctccacat 28

<210> 62

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 62

ggccatgagc ttaaaattct gtaaatgtaa 30

<210> 63

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 63

cacgtgtcag tgacttccaa ga 22

<210> 64

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 64

ggagttttgg ttaactcaat aataccagtg 30

<210> 65

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 65

tcacagtgat actgtccagg agtt 24

<210> 66

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 66

tatgctttca catagtcttt taaggcttgt 30

<210> 67

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 67

tggtattact attactggga cctgattca 29

<210> 68

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 68

aaaaacttcc tataggcatg aaaatgc 27

<210> 69

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 69

aaagaaataa tgggcagcta gtcctt 26

<210> 70

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 70

ggcatttact tctttgtatc atttctgact 30

<210> 71

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 71

cttgcattta tattggttgc ctgctt 26

<210> 72

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 72

tatgctcgga cacagtttgt cag 23

<210> 73

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 73

gaactgtctt ctattgaact agattcgtca 30

<210> 74

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 74

acaggataga attgaatttg aatgggttct 30

<210> 75

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 75

tttggcatat ttacttaaag ctccactct 29

<210> 76

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 76

ggaacaacat ttgtttgaca taaccattca 30

<210> 77

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 77

gttacctttt tcctttggct tttgagt 27

<210> 78

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 78

ggtgtccgtg tgtctaatta aatgactata 30

<210> 79

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 79

tagacatctc tcaccttgct ctttct 26

<210> 80

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 80

gcataggctt tcattgcatt gatttaacta 30

<210> 81

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 81

ctatagctta cattccacac tgtacttcc 29

<210> 82

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 82

ccgtatacta tggatccaga tcatagactc 30

<210> 83

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 83

acctgtttgg agttggttaa atacaatttt g 31

<210> 84

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 84

agctgtaaaa cttttgtaat agttaaaacc ttt 33

<210> 85

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 85

tttttgtatt gcatgggctg catt 24

<210> 86

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 86

gcacctatta actgtgtctg aaagatatgt 30

<210> 87

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 87

ctgcataatg taacactcaa aatacttgct 30

<210> 88

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 88

agcttggtat gtgaaaatga gatcacat 28

<210> 89

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 89

ctgagaggcc atttagacta tctcttt 27

<210> 90

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 90

gaatgctagt gtgtatctat catgtatgca 30

<210> 91

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 91

accaagtggt ttccttttca ctaaagt 27

<210> 92

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 92

ggcctcttta gcagcgattt ga 22

<210> 93

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 93

gggttctctc caaaaggttc ca 22

<210> 94

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 94

ccgctcagct acctctaaag c 21

<210> 95

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 95

acaatcatcc agatctagaa gtgaaacatc 30

<210> 96

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 96

ccacagattt ttaaaacaga acgtgtgat 29

<210> 97

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 97

ctgagacagg acaggcttca gt 22

<210> 98

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 98

cctgcagcaa attatttcat ttgacaaaaa 30

<210> 99

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 99

tccttttaat ggaccggcac ttt 23

<210> 100

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 100

attgcttagc taagtcttag ctattgctaa 30

<210> 101

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 101

caggtttaag tgacacttct ccaga 25

<210> 102

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 102

ttttgatctc tgcagatctg gcaaata 27

<210> 103

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 103

cttattccgg tattactgtg tctccat 27

<210> 104

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 104

accagaaagg caagtcattt cataaaataa 30

<210> 105

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 105

ccctggaaaa gaggtaaacc ttttg 25

<210> 106

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 106

cccagtccac aaaccaaatt atttttaatg 30

<210> 107

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 107

actaaccata tactctttct gcttcttagc 30

<210> 108

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 108

cggcgtccca aagcgtt 17

<210> 109

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 109

agcgtgatac ctttagtgtt ttctagaatt 30

<210> 110

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 110

ttccatctta ccagaaatgt attgtggatt 30

<210> 111

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 111

gagggctaag aactggtttg tttaaag 27

<210> 112

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 112

cgctgtacta cctttgtcag atatcatatt 30

<210> 113

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 113

cgtttctgag tcatttggga ccaa 24

<210> 114

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 114

ccaggttata atgctatgca gccta 25

<210> 115

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 115

gatgtcacga gtcactagta tagactatct 30

<210> 116

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 116

tgtgccttgt catttgttca ataaatttga 30

<210> 117

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 117

tgtaaaccag aagtactgtt attttggtga 30

<210> 118

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 118

ttcagtggtg cgatcagaat tca 23

<210> 119

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 119

gacaacgctc ttccggtctt 20

<210> 120

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 120

gccggacaga agagattgtc g 21

<210> 121

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 121

tgtttcaggt tttgcaacat tttgga 26

<210> 122

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 122

gttttaggca cgtacagtca actg 24

<210> 123

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 123

ttttctgcaa aatagtgaat tggtacttgg 30

<210> 124

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 124

cagacgaatg tatgagggtg tataattgtt 30

<210> 125

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 125

gccattctga gtttatgtgt tgactc 26

<210> 126

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 126

gcaggaatag ggatgaagta atatcacc 28

<210> 127

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 127

aattacctca aagcagagca ctgt 24

<210> 128

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 128

cacaactttt cacatccttt tggct 25

<210> 129

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 129

ttctgacgag ccacacgttt 20

<210> 130

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 130

ccgccaaaaa ccgcttactc 20

<210> 131

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 131

gtgaagataa ggctgtaaaa attttgacca 30

<210> 132

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 132

aagaatgtga aagaattttc aactcacttt 30

<210> 133

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 133

cccaacctcc ttttattagc tgtgt 25

<210> 134

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 134

tgctttgtct tctatagtca agtcctcta 29

<210> 135

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 135

gtggagcaac tggcagaagg at 22

<210> 136

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 136

tcctctattc ccatctgcta tcaataaaga 30

<210> 137

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 137

gggccagacg acgatatcag 20

<210> 138

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 138

aaacgtgtgg ctcgtcagaa 20

<210> 139

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 139

ctggaaagtg gtttgattat tgtgagtc 28

<210> 140

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 140

accaaaaagc tatagagctt ctgatgaa 28

<210> 141

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 141

aaaaatttct tgaagtggaa tgatgtacac 30

<210> 142

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 142

acctcgtatt tccctcaaac aataaattct 30

<210> 143

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 143

acagagcctg tgaagatgta tgaatg 26

<210> 144

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 144

atcattcatt aaagaaggca aatgctcttt 30

<210> 145

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 145

cagacaatgt cacctaaatt gctgaat 27

<210> 146

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 146

tgtgcaggaa ccagcatttt aaac 24

<210> 147

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 147

ccacaggctt agtggtacgt tg 22

<210> 148

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 148

tgggtagctt ttaaagtatt tcatcgctta 30

<210> 149

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 149

gttagctaat tgaacttttg tgacctgt 28

<210> 150

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 150

ccatcacagt ctagtaaggt atgtttttgt 30

<210> 151

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 151

cgtatcttac tgactaaact ggaatggaa 29

<210> 152

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 152

cccaaaaact caatgaggac acaatctata 30

<210> 153

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 153

tgagtgagta gaactccgga gaa 23

<210> 154

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 154

ccactgccgt atgacaaata acca 24

<210> 155

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 155

ctcgcagaga cctaggcat 19

<210> 156

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 156

gaggacggtg gtcggttt 18

<210> 157

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 157

agaaggagtt tgaaagagaa aagcagtta 29

<210> 158

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 158

gcaacatgac gtctgctact tg 22

<210> 159

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 159

caaaaataag gaacttgttg ctacctttct 30

<210> 160

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 160

ctttgaaccc aaaagccaca gaagca 26

<210> 161

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 161

gctgtactta cccttcttgt gatgata 27

<210> 162

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 162

aaggagaaac aaaaagttta tgtaggccta 30

<210> 163

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 163

ccagatgtgt gagccaggta ag 22

<210> 164

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 164

cggtatgcaa ggatcacact ga 22

<210> 165

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 165

ccctagataa ggtcagcctg tttc 24

<210> 166

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 166

ccctcgtgta tgcattctct ct 22

<210> 167

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 167

gaagcaagtg gaccttgaag gt 22

<210> 168

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 168

cacagagagt tgcctggaac tt 22

<210> 169

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 169

ccctcctatt acagcccaaa gat 23

<210> 170

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 170

ggtgggtttc agtgagattc cag 23

<210> 171

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 171

ccaagactca tcggatctcc ttct 24

<210> 172

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 172

ggttttcggt aatcctcctg gat 23

<210> 173

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 173

ctaaggaagg ctcatgtgtt gga 23

<210> 174

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 174

ttctgtgccc agttgctgat 20

<210> 175

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 175

gtgacagagt gccttttcga ga 22

<210> 176

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 176

ccaggaaact ggattttggg act 23

<210> 177

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 177

gtgaaggact gtgaccagca ta 22

<210> 178

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 178

cttgaagaag gccaaagctt tgg 23

<210> 179

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 179

tcagcccacc cacttacctt at 22

<210> 180

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 180

cagaaacagg ctgaccttat ctagg 25

<210> 181

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 181

gccagacaga aagctcctag gat 23

<210> 182

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 182

tcacaaggat gcgaataaaa tcgga 25

<210> 183

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 183

cacgcctgga atctcactga aa 22

<210> 184

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 184

gctccacagg actttctcct ttg 23

<210> 185

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 185

gcagagcctt gtcattacag ct 22

<210> 186

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 186

tctgtcacgt gtacacagga aag 23

<210> 187

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 187

ccagcttgga ggtgctaact c 21

<210> 188

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 188

ctcttacctg gctcacacat ctg 23

<210> 189

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 189

tctctgatcc aacccacctc tt 22

<210> 190

<211> 48

<212> DNA

<213> Rabbit calicivirus

<400> 190

tctctgatcc aacccacctc ttcctccttc tgaccatcat ttctcttt 48

<210> 191

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 191

gggatgtgaa tggtaatgat ggct 24

<210> 192

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 192

ccctctgtaa agccctggtt tataa 25

<210> 193

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 193

cctaatacct cctcccttcc cat 23

<210> 194

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 194

aagaaatcac ttctggctgt cagtt 25

<210> 195

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 195

actctcagcc agtcccttag ac 22

<210> 196

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 196

tgcagacatc atgagtactc ctttg 25

<210> 197

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 197

cacgaaacgt gtagcgtttc tg 22

<210> 198

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 198

aggagtatgt tttaattctc ccttctctca 30

<210> 199

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 199

gtagatggaa agaggaaggg agggaaa 27

<210> 200

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 200

cccaatcctc tgacagaaga acc 23

<210> 201

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 201

ctctgctatt gtcagctacc gtt 23

<210> 202

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 202

caggagctgt tgtgaggatt aaaca 25

<210> 203

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 203

aaggaaagtt agtaccactt agggcta 27

<210> 204

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 204

ctgacctgga catatctgtc tttagg 26

<210> 205

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 205

caggcagttg gcagttgata ga 22

<210> 206

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 206

gacaactggg agaagggtga taaaaa 26

<210> 207

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 207

gtctggttga atcctttagc ccta 24

<210> 208

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 208

gcactacctt caggatcctg act 23

<210> 209

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 209

aaaaagtcag tttccagaac agtactct 28

<210> 210

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 210

ccttcctttt cgcaggattc ttc 23

<210> 211

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 211

cccttcccac tccacttttc aat 23

<210> 212

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 212

ctacacccag ggaatgaaga gcaag 25

<210> 213

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 213

aacaaatgtt tggtagaggt ggatct 26

<210> 214

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 214

caagagagag ggtagcaagt ctc 23

<210> 215

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 215

gtgacaggga agtggagcaa aag 23

<210> 216

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 216

tggattatag acataagttc tccttgccta 30

<210> 217

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 217

ataaaattgg tagcccttga tagactgac 29

<210> 218

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 218

tcaatgatta aaggccaaaa gcttttactt 30

<210> 219

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 219

aaaaagccaa tggatcttat ctagcagt 28

<210> 220

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 220

ccggctgtga ctgaagattt taac 24

<210> 221

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 221

gcactgcagt aaagcaaagg act 23

<210> 222

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 222

atccagaacg aacctgggaa ga 22

<210> 223

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 223

gctgtctgtg ggctttgtca tt 22

<210> 224

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 224

ggaggtcctc aaattgtata cgaca 25

<210> 225

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 225

aactttaaaa tgtcttatcg caaatgcca 29

<210> 226

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 226

tcctaactta aggaggattc cttaggac 28

<210> 227

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 227

cctccttctg tgggcaagaa ag 22

<210> 228

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 228

tcttgcactg tctaactttg ttgtctt 27

<210> 229

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 229

ctgcagatcc tgaatggagg aa 22

<210> 230

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 230

ccacatgtga caagaggcta ga 22

<210> 231

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 231

gaatctaaag tttatggttc cagggactt 29

<210> 232

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 232

agagaggtag cagcatactc tgt 23

<210> 233

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 233

ggtctcttct tttataccaa gctcatcttt 30

<210> 234

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 234

ggagtctcaa ccttaaaatt gctcaac 27

<210> 235

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 235

ctatatgcaa ggtgaatatg tactgagct 29

<210> 236

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 236

agctctagac tttctagttc catcact 27

<210> 237

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 237

aacggattgc agagggaata aatacaa 27

<210> 238

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 238

cttttaaagt tgctttgaag ctcgtctat 29

<210> 239

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 239

actggcttga gattcagatg ca 22

<210> 240

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 240

gcttgaaaaa ggtaatacca tgcaca 26

<210> 241

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 241

tagagaactc ccttatacag agttttggt 29

<210> 242

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 242

cctatgcacc atatttatta aaatgcagct 30

<210> 243

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 243

tcaagccatt agcaaaggct gt 22

<210> 244

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 244

catgatccag ttcttgaaag gtggt 25

<210> 245

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 245

aaccagcaga cttttgtgaa aatcac 26

<210> 246

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 246

tttcttcagg ttcccaaagt ggt 23

<210> 247

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 247

tcatttgttt aagtgagaac aatccctgt 29

<210> 248

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 248

aatctaatga cgctgatctg acagaag 27

<210> 249

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 249

attagacaaa atgaccattg gctattttgg 30

<210> 250

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 250

ctgggtgcgt agataatctg aca 23

<210> 251

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 251

tcattaatgc cactctcctt ctttcc 26

<210> 252

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 252

caatctcttg cacaaaagtg agct 24

<210> 253

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 253

ggcccttttt ctcagaaaaa ccc 23

<210> 254

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 254

agccagggtt tgaaaactat ggg 23

<210> 255

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 255

gctcagtagg tctgctgtca gt 22

<210> 256

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 256

cacactctat tctattgtgg aacccaa 27

<210> 257

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 257

aagcactggt agaaatagaa aatgaccat 29

<210> 258

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 258

ccagacatga gacagtgcac tta 23

<210> 259

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 259

gtgaagtctc aggaatggga ct 22

<210> 260

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 260

gtctgcattt gataaaggaa acagct 26

<210> 261

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 261

gcctggtgtt tgagttcatg ga 22

<210> 262

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 262

agtgagaact gtccctttac cct 23

<210> 263

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 263

ccagaataaa attagctttt gcgtctga 28

<210> 264

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 264

ggtaggctca tggccagttt at 22

<210> 265

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 265

caacatggaa gcacatacaa aaatcca 27

<210> 266

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 266

gcagcttcta atgctctatg gaatg 25

<210> 267

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 267

gagccagaac aggagtgatg tc 22

<210> 268

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 268

ccatatcctg ggatactgtg ttgttg 26

<210> 269

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 269

ccggatattc tgagaagcag ctt 23

<210> 270

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 270

agaagaggag gcatagtcac ct 22

<210> 271

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 271

ttggcgagca attgaaactt gtt 23

<210> 272

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 272

cagggtgaac agagattttg cag 23

<210> 273

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 273

tgtaactgag gctttaaaaa gccaaga 27

<210> 274

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 274

gctagtggtt ctatactgac ttctttactg 30

<210> 275

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 275

acaaccaacc agtcatgttg ct 22

<210> 276

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 276

cttgaggctc tccacttcac aataattata 30

<210> 277

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 277

aattgactga tctctgtggt ttggttta 28

<210> 278

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 278

tcaaaaggta caaaatgcaa aatctacgaa 30

<210> 279

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 279

gtctttgctt ggttttgttg tctct 25

<210> 280

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 280

caaatcatcc tggtatttta tttgttcgca 30

<210> 281

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 281

cagacacaac ctcagagtcc tttt 24

<210> 282

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 282

taggattgtc atttgtttcc ttgatgtga 29

<210> 283

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 283

tctcttccag ggaaatgggt gat 23

<210> 284

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 284

catttcaaga acactgaacc gatgttc 27

<210> 285

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 285

cctttggttg tgctaagagg tgat 24

<210> 286

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 286

agtccaaaca taaaatgcta tgcgaaaa 28

<210> 287

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 287

gtgtgttaag tggttggctt ttcat 25

<210> 288

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 288

acaaatatag agggcttttt agggagagt 29

<210> 289

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 289

ctgaatctga atcagaatca aacattcagg 30

<210> 290

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 290

tttggttcag tttaagacaa gacattagga 30

<210> 291

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 291

tctagttgtc tgtcaatcct agtacaagaa 30

<210> 292

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 292

agatgcagac atctagggag ctt 23

<210> 293

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 293

atgatgaggt tctaataaga tgctctgaac 30

<210> 294

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 294

ttcatagctt gcattttaaa cttgttgtca 30

<210> 295

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 295

atttaccttg gtgttatcaa atgccaac 28

<210> 296

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 296

ccatctgcca caaaaagatt ttctgtttta 30

<210> 297

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 297

cgtagtcagc aagtataaat gggaaca 27

<210> 298

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 298

tctttggaga aaagtgccaa taagactaaa 30

<210> 299

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 299

aaagtttatc caatttaatg gcatgctgt 29

<210> 300

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 300

atctagtctg ctttgcagaa atcttttact 30

<210> 301

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 301

taattagagc agcacagagg ccatt 25

<210> 302

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 302

atctcctcca gatttggaat tattgacaat 30

<210> 303

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 303

ccacacccag ccgagaatta atata 25

<210> 304

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 304

gatgatccaa gtgtgggctg at 22

<210> 305

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 305

gctgttgtat attcatgaaa gagtgaaggt 30

<210> 306

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 306

ggtaatagtg gcttcttgac tcaacatat 29

<210> 307

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 307

aagtgccaca aaaatttgat gttcatagt 29

<210> 308

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 308

gctgcatatt tttcagtaag tatgtgct 28

<210> 309

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 309

atgctatgtt tgatttggag accttct 27

<210> 310

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 310

accatttgag tcactttggt tgttttattt 30

<210> 311

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 311

gcaagctcac ctgaatcaca ca 22

<210> 312

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 312

tgccttatgt acaataggta catagactga 30

<210> 313

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 313

aaagtgttta cctggtactg ttgtgaa 27

<210> 314

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 314

cagtcgagca gtgacaatct gat 23

<210> 315

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 315

ggaacataga tggatatttt agccaggtt 29

<210> 316

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 316

tttgcagttg gctggaaaat gg 22

<210> 317

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 317

aagtacatat tacatgcctc tgctttactc 30

<210> 318

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 318

gtttctgttg aacttcctga ttaaccaatt 30

<210> 319

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 319

taaacacaga ggttaaattg agcctgt 27

<210> 320

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 320

tgcacaagag agaaagcaaa tttttgaaat 30

<210> 321

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 321

gataagtcag gacctaccac cacta 25

<210> 322

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 322

tgtttccctg tggtttaatg tggag 25

<210> 323

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 323

cttctcaata aacccatggc cttact 26

<210> 324

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 324

ctgatatgtg tgggtatgtt tgtattttca 30

<210> 325

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 325

tgtgctgggt gtctcttgtt ag 22

<210> 326

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 326

ctagatggca agatctttca ggagaaa 27

<210> 327

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 327

gctggatgat gcaaaaatat gacca 25

<210> 328

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 328

gttaaccacc catcaccagc ta 22

<210> 329

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 329

ccttgttcct tgctatatgt catcagaag 29

<210> 330

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 330

tctacactta ccacctttta aaaagcca 28

<210> 331

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 331

tcatctgaca cttataaaat gtgtgtgtgt 30

<210> 332

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 332

tcaacagaag atggaattgg agttacc 27

<210> 333

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 333

gctgaaactt cttccacatt tatggaag 28

<210> 334

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 334

ttcagaagtc acaaagagga gcaaggaaaa 30

<210> 335

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 335

ctgaactcaa catgtagatc caacga 26

<210> 336

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 336

cggaagactg ttaaccaaga tgttcata 28

<210> 337

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 337

tcaatatctg gaactgaggc atctttc 27

<210> 338

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 338

gtatatccca catgcaatag cgatatatta 30

<210> 339

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 339

gcatatttac tgtacaagga gatttctcca 30

<210> 340

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 340

cttttggtga aattgctcat ttattcctct 30

<210> 341

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 341

ctcctctttg gagcacagga ttaaata 27

<210> 342

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 342

atgctgaact ctcctcaagt ttatcc 26

<210> 343

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 343

caatatatgc tgctgaaaat ttttcagtgc 30

<210> 344

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 344

caaaaaccca tttgaagaga ctgca 25

<210> 345

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 345

tgacagtgct cattattttc atcacact 28

<210> 346

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 346

gtcatagagc ccttctttta cctgag 26

<210> 347

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 347

tttttcctaa gattttctgg catcatctct 30

<210> 348

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 348

ctcctttagc agccagtgta gtg 23

<210> 349

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 349

ccctgtcttg gaataatctc tctgga 26

<210> 350

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 350

agacgacagc gtaaaattac ccatc 25

<210> 351

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 351

cttcatgagt tgagtcattt tggaaagg 28

<210> 352

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 352

gaacagtctt ctgttttcaa tccatttcag 30

<210> 353

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 353

ccacttgtag gtattcacct gaggta 26

<210> 354

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 354

gtatgctgga attaaatttg ctttctgcta 30

<210> 355

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 355

taagtggcat aatgaagacg tttcca 26

<210> 356

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 356

gaagccacag cactattgca ag 22

<210> 357

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 357

tgatctgctt tgaccactgg aaat 24

<210> 358

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 358

gggttgtagt atcgacaggt tacaaaatat 30

<210> 359

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 359

aagagaccaa tatccacatc tttcttgg 28

<210> 360

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 360

gtggacccaa ccatacatct gtaa 24

<210> 361

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 361

ccttttgctt atacccaaac accaa 25

<210> 362

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 362

cagctatttt tgtgaactct taagacctg 29

<210> 363

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 363

ggagcacttt gggcaaggaa ta 22

<210> 364

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 364

tatcactatg gctcccacta ttccaata 28

<210> 365

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 365

tcatttcaag ttcatcatca atgatagcct 30

<210> 366

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 366

gcacagcaga actgcttatg aa 22

<210> 367

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 367

ctagcatcga acacattcaa agtgg 25

<210> 368

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 368

ctagccaagc aactgaaacg gaact 25

<210> 369

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 369

aaaaagacaa aagattccca attatagtgg a 31

<210> 370

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 370

gttgtatctt catcgaggaa ctcaagaatt 30

<210> 371

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 371

ctcccgcagc ttacctatca tg 22

<210> 372

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 372

tgttctgata aatacgttcc atgtatgctt 30

<210> 373

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 373

cttcactcca tgttcttaac cactca 26

<210> 374

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 374

gcagatagtg aaagcaatcc tgaaga 26

<210> 375

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 375

gttcagaggt acacagaaag gct 23

<210> 376

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 376

gcataatgct cttttacttc ttctccaaat 30

<210> 377

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 377

gagtttctaa gaagaaagag attgtgctca 30

<210> 378

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 378

cttgcttgtg atatacagca acttttca 28

<210> 379

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 379

aattaatgag agtataactc gcagtgctaa 30

<210> 380

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 380

agccttacat aggtagagta tgagcattaa 30

<210> 381

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 381

tactgtccat cccatcacat atcca 25

<210> 382

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 382

gattgaaaca caactagcaa agcctttatt 30

<210> 383

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 383

tgcttgtaaa tctgtttgtg taggct 26

<210> 384

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 384

cacgtttctg tttcaagaaa tgtttaccta 30

<210> 385

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 385

cagcgattac attgatagat actccct 27

<210> 386

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 386

caataaacaa atgagcttgc ccttca 26

<210> 387

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 387

tgcatagtgg agctaaagac agaac 25

<210> 388

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 388

tgcatgttgt agcaaacatt tctgtaaa 28

<210> 389

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 389

cactcttaac aagaccagtt attctgcata 30

<210> 390

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 390

ctattcacgt tgaagtgatt tgctttgt 28

<210> 391

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 391

catgtgtatg cagtttaagg ttaaagca 28

<210> 392

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 392

tttgaaaaca ctgtcagata agctcagta 29

<210> 393

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 393

acagacggct ccaagatgtt tag 23

<210> 394

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 394

gcatgggtat taagaacaca gcctaaata 29

<210> 395

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 395

aaacttcttg catactgaag gctt 24

<210> 396

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 396

ctttcttagc tcaaaggaga accagaat 28

<210> 397

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 397

cataaaatat ttggtacaga ggcacctact 30

<210> 398

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 398

tcccaccaag gtattccaaa gaaaatatt 29

<210> 399

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 399

agtgcatatt gacacaatct tccagat 27

<210> 400

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 400

aatgttctat tccttcctta gcagctatg 29

<210> 401

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 401

agtctgcccg taggttttta tcatg 25

<210> 402

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 402

gtgttgtttt tccctttggt attattgtca 30

<210> 403

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 403

ccaactgcca tgaggttgga ta 22

<210> 404

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 404

cagatcagtt gtgacttact tactcaatct 30

<210> 405

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 405

ccggttgaca tcggtcagaa at 22

<210> 406

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 406

gccaatcttc agttagaaac aaacaacaaa 30

<210> 407

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 407

tgagaaaagc actaaaagta aggagca 27

<210> 408

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 408

caccgcaaat catgactctg aaaa 24

<210> 409

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 409

acccggaacc ttctgcc 17

<210> 410

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 410

gggtggtgtt ctcggtttc 19

<210> 411

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 411

caacaacatg gatgaatttc agagacatg 29

<210> 412

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 412

acaaaacaaa atccaaatat ttacacctgt gt 32

<210> 413

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 413

tcgaactcca ggcctcaagt a 21

<210> 414

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 414

cgcccagctt attaatagac atttaatata aag 33

<210> 415

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 415

cagttggtgg gaaagggctt aa 22

<210> 416

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 416

gaacagtaga tgtgcctttg gagt 24

<210> 417

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 417

acaaagaaaa taccgtattt ggaatccaat 30

<210> 418

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 418

ctagtctgta gtgttagcca ttctaaaaga 30

<210> 419

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 419

ttcccaaaag aaaaattatt gctgctgt 28

<210> 420

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 420

gtggctttta gtgtagtcac aggta 25

<210> 421

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 421

gggatctata gatttggaga aaacatgtat gtt 33

<210> 422

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 422

acaccatgct ctgttcttcc c 21

<210> 423

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 423

ctgttaagca agctgggtct ctt 23

<210> 424

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 424

ttttggcctc tttcagtgtt tattcattc 29

<210> 425

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 425

agtaaaaacc tagaagtttc tgtattctgt tt 32

<210> 426

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 426

catatgggtc tctggacaga gg 22

<210> 427

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 427

aatcactcat ttaacaaatc acattcatga aaa 33

<210> 428

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 428

cgggactaca agtgtgcatc ac 22

<210> 429

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 429

gctggaatgc ctcaggtaca tg 22

<210> 430

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 430

gagtaagtat tcacatatcg tgtgccttaa 30

<210> 431

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 431

agctgtgtct ttcttgcatc tct 23

<210> 432

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 432

ggctgtcacc ttaaaattga gttttaaaac 30

<210> 433

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 433

agatactttg aatccttcta ccagatatgt a 31

<210> 434

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 434

attactattt ataatggcaa gatagcagtg at 32

<210> 435

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 435

tacaaaataa ccacaagccc tcagaa 26

<210> 436

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 436

ggcctcaaat agaattaggt ctttgtgt 28

<210> 437

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 437

cacctggcca gaagccatta tta 23

<210> 438

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 438

attatgacat tgcagttgtt tcatgctt 28

<210> 439

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 439

tccatagtta agcatacatg gaacgtattt 30

<210> 440

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 440

attagtttgt tgggctctgt gaca 24

<210> 441

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 441

gtttctttga ttgggtggca acat 24

<210> 442

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 442

caaaagagag gtggttccac ttaatagatt 30

<210> 443

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 443

gggatgcact tgtgaccaca ta 22

<210> 444

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 444

ggtgctttat ttaaatcaga tgcaaccaaa 30

<210> 445

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 445

aactcagacc aatctataca tagagtgaca 30

<210> 446

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 446

aggactccag agaccatgca tta 23

<210> 447

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 447

gtagtttcaa gccttcaaaa tcatgttga 29

<210> 448

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 448

gccactgatt atgtcacaac tttgttaaaa 30

<210> 449

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 449

aatttctgaa actcctgtgt ccttatgaat 30

<210> 450

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 450

tcatctgttc cgtggctttc tc 22

<210> 451

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 451

ttacataaga gttggactaa ggacaaggta 30

<210> 452

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 452

gagtgctgac agtttaggta aattagagtt 30

<210> 453

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 453

gtagtcattg actggcttgc cata 24

<210> 454

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 454

gaacaactga aagaatctgg ctacaaaaa 29

<210> 455

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 455

ctttcctttt tctgtagtac tctcagct 28

<210> 456

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 456

cggtgtttca tcacaaaagt atcctg 26

<210> 457

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 457

tcagtctatg tacctattgt acataaggca 30

<210> 458

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 458

cggaacctgc atcatatggg atttaa 26

<210> 459

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 459

tgacaatact aacttctgca taagctgag 29

<210> 460

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 460

gccagtgaaa cctcaggtga ta 22

<210> 461

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 461

tgcccttact ttaataacac cttgttgt 28

<210> 462

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 462

cacagttcct aaggtaatca tcaagtactt 30

<210> 463

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 463

gcctggcatc acaagagtct aa 22

<210> 464

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 464

gttgaagatc cagttcagag acga 24

<210> 465

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 465

cccttcaagt tcctcctctc att 23

<210> 466

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 466

cagagcaatc tgtggtttgt cac 23

<210> 467

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 467

ggttgagaaa ttctgtttaa atcctggttt 30

<210> 468

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 468

tatgcaccaa gcagcagaca tt 22

<210> 469

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 469

aaaaagccac acagaggaat aggtt 25

<210> 470

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 470

aagcatttga aactctgata atcagccta 29

<210> 471

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 471

agcgatatgt ctggttaatc caaattga 28

<210> 472

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 472

atgttcagaa gagctaaccc ttctttt 27

<210> 473

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 473

gcatccaatg aaaaagatct agacatgc 28

<210> 474

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 474

gaaaggcaat atagttgttc agtggaaatt 30

<210> 475

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 475

gggcaggatc ccttgaaatc tg 22

<210> 476

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 476

gggcaggatc ccttgaaatc tg 22

<210> 477

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 477

aacagcaccg ctcaggataa taa 23

<210> 478

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 478

gaggcctcag agcatttgaa ag 22

<210> 479

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 479

gaagacaaca gatcagaatc tgaagaact 29

<210> 480

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 480

cagtgttgca tcttctgtca gtagat 26

<210> 481

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 481

cccaaagcct gctaggaatt ca 22

<210> 482

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 482

cagactcctc cagatgctat gg 22

<210> 483

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 483

aaatacatgg gcaagcacat caag 24

<210> 484

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 484

catcctctga attactattt ttgccactag 30

<210> 485

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 485

cagatccgtt ctgtgaagga aaag 24

<210> 486

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 486

gtctctgtca gtgatgtccc aaag 24

<210> 487

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 487

gcctgaaaca aattttgaaa ggagatca 28

<210> 488

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 488

aaattttgcg atgtgaacaa atcagaga 28

<210> 489

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 489

aaaacctgaa aaatcttagg tgacagttt 29

<210> 490

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 490

tacgtgtcgc agaacatctg tc 22

<210> 491

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 491

gcatcctgac caggaagtga ag 22

<210> 492

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 492

catccagcac ttttctagcg ttg 23

<210> 493

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 493

tatagtcgag tgtagctttt tcgtgtg 27

<210> 494

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 494

ccaactctct caaagaccct tca 23

<210> 495

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 495

gaatttacct cactgtggag gtcaa 25

<210> 496

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 496

aatgctgtag aaatctttct aacaaatggc 30

<210> 497

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 497

tcacaattgt tgaaccaggg tgat 24

<210> 498

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 498

ggccgatcct tcaatgatct cat 23

<210> 499

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 499

taggagggtg aactgctaaa agga 24

<210> 500

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 500

tgatcagact agagtagtaa accaacagaa 30

<210> 501

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 501

ctgctaaaac agtgagcctc tgta 24

<210> 502

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 502

ccttgatcct tattaacact gggatttga 29

<210> 503

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 503

tatgtcgacc aaagaacatt tcgatga 27

<210> 504

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 504

gctttctgtg ttcttctgta catatgaact 30

<210> 505

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 505

ccctcattac ttttcttcct caagaa 26

<210> 506

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 506

gcagacattg gcaggaactt attc 24

<210> 507

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 507

ggtaagagag tggtggtttg aca 23

<210> 508

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 508

ctttttactt gcagagcagt atggtatg 28

<210> 509

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 509

agcacttcaa tgatatttta ccatcatcct 30

<210> 510

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 510

tgaaactgtc cttaacatga cttttgagt 29

<210> 511

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 511

ccagcaacat atctgctacc ttagaac 27

<210> 512

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 512

gcaagatgac ccatagttgc tatcatattt 30

<210> 513

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 513

cctgaggaac tgcaagcatg aat 23

<210> 514

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 514

ctggtcgaac aggaatttaa accatttaaa 30

<210> 515

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 515

ttggaagact ttgatgacga gatgag 26

<210> 516

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 516

gttgttgaac tcagtagctg tgaag 25

<210> 517

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 517

taattcccga gggcaactcg aa 22

<210> 518

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 518

agtcattttg ctttcatatc aactgcaaat 30

<210> 519

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 519

gtatatgtaa actaacaagg gccagaaca 29

<210> 520

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 520

aaagctgcaa gtgaatctat aaggtaactt 30

<210> 521

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 521

accctaaagc attttaagac ctaatgtagg 30

<210> 522

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 522

agctgtttac tggaagcaaa tgc 23

<210> 523

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 523

gagaacgtga agttcattcg cat 23

<210> 524

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 524

actaacctca gtatgatgac caatatgcta 30

<210> 525

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 525

actatgtaat ccaaaaccat gtagctacag 30

<210> 526

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 526

catgagcacc gacagtaact ca 22

<210> 527

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 527

tgaagaggca gtgtatataa aggtaacaga 30

<210> 528

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 528

ccctattaga atagggttgc tactcatctt 30

<210> 529

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 529

aaaaatgaaa gctagacaat agctgca 27

<210> 530

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 530

tgtcaagata gattcgagag aaagcac 27

<210> 531

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 531

cttaggcagg gatacatatt tttatccca 29

<210> 532

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 532

tgtattccac agcaaactta cataccataa 30

<210> 533

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 533

gggaagaaaa ttcttcctgc agattag 27

<210> 534

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 534

gctatttaca gagcattgaa tctgtaccaa 30

<210> 535

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 535

tccaagatac ctgtattctt gtttgtgg 28

<210> 536

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 536

ggacttgata attgctttct ttgagaagc 29

<210> 537

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 537

tctactggtc cttttggaat catagaaaaa 30

<210> 538

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 538

acatgatcct aagaggaaag ttctgttcta 30

<210> 539

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 539

actcaccgtt gaagagaagc aaa 23

<210> 540

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 540

tacttagtac tagacttcct aaagtcattg ctt 33

<210> 541

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 541

gctgaggata atcaataccg aaagataaga 30

<210> 542

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 542

actcagttgt tacgaaccat tttactga 28

<210> 543

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 543

ggctagagaa agagggagaa catt 24

<210> 544

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 544

agctgttaga ggaactattg cttgac 26

<210> 545

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 545

acagtctcgt agtatttcct gatgatttg 29

<210> 546

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 546

ggtattgctt aagcagtctg atcctaat 28

<210> 547

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 547

gtatgcctac atatttaccc aggacaa 27

<210> 548

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 548

agcatctaaa tgtagctttg gaatcatgta 30

<210> 549

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 549

tactcaggtg gctgagacat ga 22

<210> 550

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 550

ctcatgaata ggagcacttc ttgagtac 28

<210> 551

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 551

atgttgataa aggcctatgt tttaaatggc 30

<210> 552

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 552

ccaagtctat tggattccaa atacggtatt 30

<210> 553

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 553

ctcaacatca ttagttgtta gaggaatgtg 30

<210> 554

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 554

ctgaaataat tcatgtcata acagcagcaa 30

<210> 555

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 555

tggtatattt taaagaagac aaagcattga att 33

<210> 556

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 556

gcacccagcc aagtttatgt atttttat 28

<210> 557

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 557

caaaattaac tgtggtgaca gatgca 26

<210> 558

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 558

actaaagaag acccaaataa ttggagcatt 30

<210> 559

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 559

ctgggtggtg atgacacagg 20

<210> 560

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 560

tacttgaggc ctggagttcg a 21

<210> 561

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 561

acctttctcg gtggtactta aagc 24

<210> 562

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 562

gtcagctgaa cagaagccag gat 23

<210> 563

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 563

ccacagaaac ctcggaatac aact 24

<210> 564

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 564

aatcggactt gatttgccaa attcc 25

<210> 565

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 565

cgtctctact aaaagaatac aaaaagtcag ct 32

<210> 566

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 566

agtaaacaaa gtgagcctcc agtaaac 27

<210> 567

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 567

gagcagaagg tgactggagt g 21

<210> 568

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 568

caagaattta aaaatgtcta ctaccatcat ccc 33

<210> 569

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 569

tgtaactgag attgagatgc attttctcaa 30

<210> 570

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 570

tgaggtcaga attttcatgt tttcagc 27

<210> 571

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 571

agattgaaaa gtgaagacta aatccagct 29

<210> 572

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 572

ttcctgttat ctaatcaaga caagaacagt 30

<210> 573

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 573

agtacaggca gcactgttac attt 24

<210> 574

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 574

gtcatgccgt atagatacaa gattccttat 30

<210> 575

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 575

ctgcaaaagc ccatccagtt ttattaaa 28

<210> 576

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 576

ccgaaagtaa ccacaataat tttgattgct 30

<210> 577

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 577

tctgaaatac atcagagcct tcatcaaaat 30

<210> 578

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 578

ctgttttact gatgataaac gagattgctt 30

<210> 579

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 579

ccatgaaaac attcttcaca gaaatttggt 30

<210> 580

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 580

cgaaagctgt tctatgtttt gctgttattt 30

<210> 581

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 581

catacaagtc tcataagaac cacagcat 28

<210> 582

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 582

gccacctgcc atttaccttc ta 22

<210> 583

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 583

cactgaaacc tccatctcct gag 23

<210> 584

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 584

agaaaaatag gctcagttag aaaaggactc 30

<210> 585

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 585

ggccatgtat aagttacact gattttagca 30

<210> 586

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 586

ctgaggcacg agacttgctt a 21

<210> 587

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 587

ctggtgtggt agctcacaca 20

<210> 588

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 588

cggtctcgct gtgtcacac 19

<210> 589

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 589

gctagacgtg tgctctgaag aa 22

<210> 590

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 590

agctcaaaac tactttagtt aacttggtca 30

<210> 591

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 591

aaagttcact gggaagagaa ggttaa 26

<210> 592

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 592

agacactgga gtactggaaa ttgaaaa 27

<210> 593

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 593

atgttcgctc ctctcccttc ta 22

<210> 594

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 594

ccaatgaaaa cgctccagat tatcttttt 29

<210> 595

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 595

agcgtagttg gagttcatac ttgc 24

<210> 596

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 596

gcctcattaa aagaacttta aatgccaagt 30

<210> 597

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 597

tagtttggaa gcaaagcaaa aagaagg 27

<210> 598

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 598

aaaaagaaag tatagactgc catggtt 27

<210> 599

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 599

cccgcacctg taactcatat gtatc 25

<210> 600

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 600

cctcctcatc tttgtaaaat gcctaaattt 30

<210> 601

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 601

gtcaaaaagc aaacagccag acattt 26

<210> 602

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 602

ctccctttaa gagcacattc ttctgta 27

<210> 603

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 603

cccagccaaa tgctgtagag ag 22

<210> 604

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 604

agtatgtcac atggtttatc aggtgaatt 29

<210> 605

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 605

caagttgcat tcttcttttc aaacacac 28

<210> 606

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 606

tgtacgtacc aaaatgctct tttatctgtt 30

<210> 607

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 607

gatggctacc acaattattt atccatgc 28

<210> 608

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 608

ctgctctcca actgcataga ca 22

<210> 609

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 609

ccttgaagtt ctggccatcc tt 22

<210> 610

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 610

gtggacttgt gtatcttcga agaagtaata 30

<210> 611

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 611

ggttagctca agtttaactt ttagtttgct 30

<210> 612

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 612

cagtgcattc accaacagga tattttt 27

<210> 613

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 613

ccagaaatac ttaaagaaac tgtcccatca 30

<210> 614

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 614

tacagttcag aatgacacat tgtagtgg 28

<210> 615

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 615

ccttctacac attttagcca gaatgct 27

<210> 616

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 616

ccttacctgc tattcttgta cttgtctc 28

<210> 617

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 617

tccatctctt tctgcaaacc acat 24

<210> 618

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 618

gtcttttggt ttctgtcagt agaaataacc 30

<210> 619

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 619

actttgtttc tccacctaaa ggaagag 27

<210> 620

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 620

cttgaactca ggagatggag gtttc 25

<210> 621

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 621

agattacagg cgtaagtcac tgc 23

<210> 622

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 622

ttcttttaag gtgacccatc tgtgataaaa 30

<210> 623

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 623

ccgcctccca ggtattaagc 20

<210> 624

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 624

tctcccaaag tgcgaggatg 20

<210> 625

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 625

acttgggaag ctgtgacagg 20

<210> 626

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 626

atgtgtgtca tgtggtcttc tgaaa 25

<210> 627

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 627

cacctggtca ggacttactt tcc 23

<210> 628

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 628

tcctctgtca aaatctgagg tatttgaaaa 30

<210> 629

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 629

gtaattgaag ccaccaaagg cat 23

<210> 630

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 630

ctcagaccta gccggagcaa agt 23

<210> 631

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 631

aatgctactt atgaagtgac tgccaa 26

<210> 632

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 632

atcaactttc ctgcaaaagg gaaac 25

<210> 633

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 633

attagttttt cagtggtgga atgtttcatg 30

<210> 634

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 634

atggatattg gaaagcgaaa gagtaagt 28

<210> 635

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 635

gtcttgtctt ataggtcaca gcactt 26

<210> 636

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 636

gagagcacaa aggacctgtg a 21

<210> 637

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 637

tgggttgcca atgtagaagt ttatct 26

<210> 638

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 638

gtcttttagg acccttccct tga 23

<210> 639

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 639

cctgtccgtc aggtactgac t 21

<210> 640

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 640

cctccattaa cgacctgctg tt 22

<210> 641

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 641

tcactttctc tctacttgat gtctcact 28

<210> 642

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 642

cagtacagct tcagcactga ca 22

<210> 643

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 643

atccagccgc actgaccaga t 21

<210> 644

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 644

aggtgacctt catccaagca tg 22

<210> 645

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 645

ccttcagtcc aagcatactg gt 22

<210> 646

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 646

tgaggtgaga tgcaacctga atc 23

<210> 647

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 647

gaaggaggcc gtcatcttgt 20

<210> 648

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 648

ccgcctacct caggcttatc t 21

<210> 649

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 649

ggtgaatcgg gattagcgtg taa 23

<210> 650

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 650

tatcgttagt gctagtggat tttacatgtg 30

<210> 651

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 651

ggatgctacg agccgcat 18

<210> 652

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 652

ccacaagttc gtgcctggt 19

<210> 653

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 653

caaagaagag cttcacatag gcatc 25

<210> 654

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 654

ggccctgagt cagtacctga 20

<210> 655

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 655

gatgaagtgg gtgccgtagt t 21

<210> 656

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 656

agtcctgaag gagttatttg attgaatgg 29

<210> 657

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 657

ccagttaagg caatgaaggc tttg 24

<210> 658

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 658

ggagattcag actgtttttc aggga 25

<210> 659

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 659

cgcaggaacc tttgtgtgtc 20

<210> 660

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 660

agggagcagt catcctccat 20

<210> 661

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 661

acctggcatg atagcggaat tt 22

<210> 662

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 662

gcaccgtgtg ggacaataac aa 22

<210> 663

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 663

gagtttaccc aggctgagta ctg 23

<210> 664

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 664

caaggcctgt gaggagaaga ag 22

<210> 665

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 665

cccagctctc acctgtagaa g 21

<210> 666

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 666

gccaaagtca gctccactga ag 22

<210> 667

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 667

tgatgcgtat ccaatctttt ggct 24

<210> 668

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 668

ggctgtcttc gtattcccat tagac 25

<210> 669

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 669

aaacgatttg tcacagaagt agagca 26

<210> 670

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 670

gctgaaggca ttgcttgtag tt 22

<210> 671

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 671

tcatttttgt tataaatgca cattgggctt 30

<210> 672

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 672

gctgggcact ccataaacag tatc 24

<210> 673

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 673

gcaaatgcca agagtttgag aaaatg 26

<210> 674

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 674

gtgaaagagg aggaagccat agcact 26

<210> 675

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 675

ctgtcagcac agccttttca at 22

<210> 676

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 676

accagtgtac tttaccaata tacagatggt 30

<210> 677

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 677

acattgagct gatgtgcatg tatattctta 30

<210> 678

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 678

ggcccagagt cttacattta agatcttac 29

<210> 679

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 679

tctcctaact ctcaggctga atcttaa 27

<210> 680

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 680

cctctacgga tcagttaagt gaagaaaag 29

<210> 681

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 681

gccagcacat aggccaagta taa 23

<210> 682

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 682

gggcaggctg gcttaatgta at 22

<210> 683

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 683

acacacaaat ttgacagact agacca 26

<210> 684

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 684

ccactggcct taaacataca attaagtg 28

<210> 685

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 685

agtgtaacca tcacgcaaat atacttgtat 30

<210> 686

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 686

gtgtcttcat accaaattaa aggtggtttt 30

<210> 687

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 687

ctttggcaat gcagcggaat aa 22

<210> 688

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 688

ccagcaggct ctgtattgtt gatattt 27

<210> 689

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 689

ctggccaacc ctgctct 17

<210> 690

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 690

tccttccact actcccataa caaactta 28

<210> 691

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 691

tttttgggtc gttggcgg 18

<210> 692

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 692

gtgttgggac aaaggaggcg ag 22

<210> 693

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 693

gggtagagaa ccgcttgtta tga 23

<210> 694

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 694

gccatatgac aaacagctga gactaat 27

<210> 695

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 695

aacgaattgg ctggcttttt cc 22

<210> 696

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 696

cctttgggat ttgtactgaa caaaaagg 28

<210> 697

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 697

gcagctggcc tccaatttca ta 22

<210> 698

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 698

cttaggactt ggtggccaat tg 22

<210> 699

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 699

gggagacaga agtcccactt tg 22

<210> 700

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 700

gtgacattct aaaataccat taaagccact 30

<210> 701

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 701

gacttctcca caaaaatact cacccat 27

<210> 702

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 702

gcatgtattg ttcactgatc atacacttac 30

<210> 703

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 703

ggattgaaga ctgtggcggt tt 22

<210> 704

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 704

cggttctaaa attaatttgt tgcagctttg 30

<210> 705

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 705

acttgacttc tcaacagcca cat 23

<210> 706

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 706

ctctcctttc cctccacatg ttg 23

<210> 707

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 707

tcaatgccca ctgttgtgat aaatttg 27

<210> 708

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 708

cgtagacata caggttaaca ttaggtgtta 30

<210> 709

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 709

cagtgagcac ctaatggaac gt 22

<210> 710

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 710

gtgaaccatg tgccaattaa gctg 24

<210> 711

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 711

gtggcttttg tgtgtgcact a 21

<210> 712

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 712

aaaaagagca gggtcataat cacac 25

<210> 713

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 713

ggaatttaaa agaagccttc atttcaagga 30

<210> 714

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 714

agtatatttg cgtgatggtt acactagaag 30

<210> 715

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 715

agccattaag atctctggaa gttttga 27

<210> 716

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 716

gcatttactg tacttgctgg gtctt 25

<210> 717

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 717

aattatttca attccaccaa tggaaaagca 30

<210> 718

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 718

ggaactagat tttatggctt tagttcactg 30

<210> 719

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 719

ccactccgtg gtcactgaaa at 22

<210> 720

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 720

aagcattggt aactccagtc tctaac 26

<210> 721

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 721

cctagcacat tttgtaggtc tttttgt 27

<210> 722

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 722

gttgactcat aactctgagc ttcca 25

<210> 723

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 723

tggatggcag ctatttgctg ag 22

<210> 724

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 724

ggattgaggc gaaagtgtgt tc 22

<210> 725

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 725

caagctcgat cgaaccaagc ta 22

<210> 726

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 726

ctgctgattt tgccatgata cacag 25

<210> 727

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 727

tgtagataat acagttcggt gagctacaa 29

<210> 728

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 728

cgtttcaaag ctcctcacta tgtacaa 27

<210> 729

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 729

agtttttgtg aaaagctcca tttttagtga 30

<210> 730

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 730

tttagtgctt gttttagcac acagtatac 29

<210> 731

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 731

cgtatttgat gctacaggat ttgaaattgt 30

<210> 732

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 732

cgtgtaggtt tcaatcactt ggaattttt 29

<210> 733

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 733

gcgctgaggg catagaagta aaaa 24

<210> 734

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 734

tatggcccat ggaccagagt at 22

<210> 735

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 735

cgtgggagta caaaagtgga gt 22

<210> 736

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 736

ctcttggaag tgaacatgca aacataa 27

<210> 737

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 737

actatgcttt acttcctatg aatgcaatga 30

<210> 738

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 738

taaaaccagc ctaaatttca aatacctcct 30

<210> 739

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 739

gcatctagca tgtcgtcaaa gct 23

<210> 740

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 740

ccaccataca atcaagcaag acattttaaa 30

<210> 741

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 741

cctctatcat caactcctta tgggcta 27

<210> 742

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 742

ttctcacact tcagttaaaa cgagct 26

<210> 743

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 743

gcatctccct tgcacagttc tc 22

<210> 744

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 744

cacagcacac ataggcagta ca 22

<210> 745

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 745

tcattgtgag ttttatgcag ttggaaatt 29

<210> 746

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 746

cttccattac aggactacaa tggctt 26

<210> 747

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 747

ggtgtcatag gctcttttgg ga 22

<210> 748

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 748

ggcagaggta aatgaaaaga aaaactcatt 30

<210> 749

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 749

tacaaaacca ctggaaagtt tatggttgta 30

<210> 750

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 750

aacaagacag tgaactgaga gca 23

<210> 751

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 751

agatctggtc tttagaggca gatagatag 29

<210> 752

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 752

gaaatggtaa accacccata atgcatt 27

<210> 753

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 753

ctctataatg tgttcattct ggaataatcc t 31

<210> 754

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 754

gaatcactcc gataagataa tcatcaatcc ttt 33

<210> 755

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 755

tgggactgct gagtaaaatg tttaagt 27

<210> 756

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 756

cagctggttt tcatcctgaa tgtc 24

<210> 757

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 757

agtaaaagaa ttctgttttt caagcaagct 30

<210> 758

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 758

cgcccagagt cccaacttc 19

<210> 759

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 759

gcgaggtcat ccactgcaa 19

<210> 760

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 760

ctgctcgaac atgtcctcga t 21

<210> 761

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 761

ctggctcttg gtattggttt gc 22

<210> 762

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 762

cgccatatgt ctaccgccat aac 23

<210> 763

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 763

ccctttccgg aactcagtct ttag 24

<210> 764

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 764

tacagtcaga tacaacttca gttccttact 30

<210> 765

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 765

tttttatgtt tttagtaaag acggtgtttc a 31

<210> 766

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 766

ctcagctatt tgtaggctga ggtg 24

<210> 767

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 767

gtgggtgaaa tgctggcttt tt 22

<210> 768

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 768

gagtgtataa aatttgcaga attgccaca 29

<210> 769

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 769

cacagattat aggtggtaac aactcca 27

<210> 770

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 770

gcctgaacat atctgcatat gacatttaac 30

<210> 771

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 771

aaagttccta acttgacagg aaactactg 29

<210> 772

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 772

gcaatgattt tcaactccgc tatca 25

<210> 773

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 773

agctgtggtc gcttcctaag 20

<210> 774

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 774

ctcaggaaga gaaaaacaaa cctggact 28

<210> 775

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 775

actttagcaa aatcatgagg ctttagaga 29

<210> 776

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 776

ggatagattt tcctggtcat aagcaagtc 29

<210> 777

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 777

cacctttgac ttaatttgct ttctctaagg 30

<210> 778

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 778

cgaactctcc aatataaaac gtgaggaatt 30

<210> 779

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 779

tactgcacca aaagaatgag tgaact 26

<210> 780

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 780

aggtgctttt acatattcag tcatcactt 29

<210> 781

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 781

agtttttaag tacagaggaa aaataaagcc tat 33

<210> 782

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 782

gaaagaacac ctgccaagct g 21

<210> 783

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 783

tacacgagct cttcttgcag atg 23

<210> 784

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 784

ctacttgagg cagggacagc agaa 24

<210> 785

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 785

ttggccttgg gaaaaaccac gt 22

<210> 786

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 786

tatcagcgaa aaatacacaa aacatgactg 30

<210> 787

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 787

ccacatcctg gagtccctgt a 21

<210> 788

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 788

cctcgctcag ctccttcatg 20

<210> 789

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 789

cgtgcagtac gaggagaaga ac 22

<210> 790

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 790

gctggtttgc aattcttgaa cctg 24

<210> 791

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 791

gcactgaata tcgaacaagc actca 25

<210> 792

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 792

gggcaaactg gagtgaaaca aa 22

<210> 793

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 793

cagtttgggt caaacttcat gttaaaca 28

<210> 794

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 794

agtaaactaa atggtcaagc cagaaatgta 30

<210> 795

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 795

gcgcgtgcca caatgtc 17

<210> 796

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 796

ctgggagttt aaggctgcag taa 23

<210> 797

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 797

tgaaaggtga ctttggccaa ga 22

<210> 798

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 798

gcatactaga tgagcacctt tcctagt 27

<210> 799

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 799

cgcaacaggt ttccttctcc at 22

<210> 800

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 800

ccaaaatccc acctaaggca ca 22

<210> 801

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 801

ctcaaacttg tgagcttgag caatc 25

<210> 802

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 802

ggtaagggca ttaagaagtt tgcag 25

<210> 803

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 803

gagatcatgg gcaaggaagt ct 22

<210> 804

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 804

tacgttgagc tcgatgacgt tc 22

<210> 805

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 805

tagaaggagg agtatgtgaa ttctttgga 29

<210> 806

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 806

tgcagtggag ctatgtgaac attt 24

<210> 807

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 807

tgcttggaac cattataaaa gtaagtgagt 30

<210> 808

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 808

agcaggaaga agaagtgttc tttcc 25

<210> 809

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 809

aaacggagat aacagtactt acctcataga 30

<210> 810

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 810

gggtcttggt ttctttattc cattttatta ttt 33

<210> 811

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 811

ttccaccaaa aacacgtaag caggaa 26

<210> 812

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 812

ctcttggtgg cactagaaca ca 22

<210> 813

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 813

caccttgcac tcttaccgtc tt 22

<210> 814

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 814

catagcgtag accggatgaa gaatc 25

<210> 815

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 815

tgtcatatgc agatatgttc aggctcta 28

<210> 816

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 816

ctgcagttgg agatacttcg cata 24

<210> 817

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 817

caattgtaat cagagcaaca gttgact 27

<210> 818

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 818

tcgttttaaa gcatcctttg tagtctca 28

<210> 819

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 819

gacagagtga gatcctcctc tctt 24

<210> 820

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 820

ccataggcct gatgatgagc t 21

<210> 821

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 821

gctgagatga ggtaggaccc aaa 23

<210> 822

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 822

ccattccgaa ggaggatgta gag 23

<210> 823

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 823

ccctgactct caccttcaaa c 21

<210> 824

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 824

ctgggagcgg gttttctct 19

<210> 825

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 825

ggtgtggcca tgtcagagat g 21

<210> 826

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 826

cgctgccttc gtctttgaca 20

<210> 827

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 827

ggcgtatgat ctgctggaca ta 22

<210> 828

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 828

gacacatctg cgatatgcat gtg 23

<210> 829

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 829

taacctgcct ctcggcc 17

<210> 830

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 830

tgtgccagtg accgaagcg 19

<210> 831

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 831

cagactggcc tccaatttca c 21

<210> 832

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 832

gtctcagtcc aggctcgaaa t 21

<210> 833

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 833

ctccctttcc agagaaataa actcttcc 28

<210> 834

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 834

aggctaattc tccttctgag aggataatag 30

<210> 835

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 835

gggttgtcca gccagctta 19

<210> 836

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 836

gggcagtaga ggttgtaggt 20

<210> 837

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 837

catccatctg gacaggtgct tatc 24

<210> 838

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 838

gatcctacac tcaagggctg aa 22

<210> 839

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 839

agtctggagg ccatttattt gct 23

<210> 840

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 840

cgtatacaca tgcacacatg caatc 25

<210> 841

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 841

ggttcaggcc ctgatcaaag ac 22

<210> 842

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 842

ggaggaaggc aaggtgaatc tc 22

<210> 843

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 843

gagcccacct atcagctgt 19

<210> 844

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 844

ccctaagccc tgaggcttag 20

<210> 845

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 845

ccaggcgaac atcaaagacc ta 22

<210> 846

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 846

cgagcccttg aagtgcttca ta 22

<210> 847

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 847

cacagctctc cttgggtcat tt 22

<210> 848

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 848

tagtgtgagc aagagtggga aac 23

<210> 849

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 849

ctccagcgac ttcgtgc 17

<210> 850

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 850

ccggagaggc actcactt 18

<210> 851

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 851

tccagcatgc caatgtacag g 21

<210> 852

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 852

taagctggga ctgggagagg c 21

<210> 853

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 853

gggagcctgt caaagacgaa g 21

<210> 854

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 854

gactcccttg ataagaaggt gaggta 26

<210> 855

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 855

gtcactggca caagaacaag gct 23

<210> 856

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 856

cctggtgact taccaatgag ca 22

<210> 857

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 857

cccaggtgtt ctccctcgat 20

<210> 858

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 858

ggtgttgcac gcggttaag 19

<210> 859

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 859

gcaaaggtgg tgaagacgtt ga 22

<210> 860

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 860

cagtgtctgt ttctgaggga aca 23

<210> 861

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 861

ctcctgagga ccttctgtga ga 22

<210> 862

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 862

ctggtactgc ggcatctttt tc 22

<210> 863

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 863

cagtattcta cgcacctgca tcta 24

<210> 864

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 864

ctaggaccgt ttctccacaa gac 23

<210> 865

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 865

gggagaagat caaggactcc atga 24

<210> 866

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 866

cggtgagtgc aaatgaccca a 21

<210> 867

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 867

ccagaggcag ctcatcatca g 21

<210> 868

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 868

gaagacaaga tgcgcatgct t 21

<210> 869

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 869

gctcttagct ggtggtccct aa 22

<210> 870

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 870

ctcactcatg taggcacctt ct 22

<210> 871

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 871

ggacgaggac gatgacttgt g 21

<210> 872

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 872

atgagggcca aagacttggc a 21

<210> 873

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 873

ctgaacgcct tcaaggcaga ca 22

<210> 874

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 874

gttccaagtc tgcagacctg tat 23

<210> 875

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 875

gggaaagtga gtgcctctcc 20

<210> 876

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 876

ttctggcacc ggagagcag 19

<210> 877

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 877

ttctctctct cgctttcttg ctg 23

<210> 878

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 878

gccacccagt acctccatta c 21

<210> 879

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 879

atgtgggtgc gacactagtg 20

<210> 880

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 880

cactgtcggt gaagaagata tggg 24

<210> 881

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 881

cccaaggagt tatggaatta gattcgt 27

<210> 882

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 882

atacgaaggg ccacaggttc ct 22

<210> 883

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 883

cctccaggtt tcccactctt g 21

<210> 884

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 884

ctgctccagg ttacggatga g 21

<210> 885

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 885

gagcttggaa gggattttgc tg 22

<210> 886

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 886

gcctcttggc tgagtaagct tg 22

<210> 887

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 887

ctctatcacc agttcctcat gacttc 26

<210> 888

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 888

tcaatgtagg tcttgtggtt cagaac 26

<210> 889

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 889

ctggtctcac agctcaaatg gt 22

<210> 890

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 890

cccaaagttc tgattctcat tggagaatat 30

<210> 891

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 891

cctctcaggg catgatcaca ag 22

<210> 892

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 892

cctactcacc cacagaatgg tg 22

<210> 893

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 893

gacaaagtcc aggtgtcctt ga 22

<210> 894

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 894

ggagtctcac gtgaatcctc ctaa 24

<210> 895

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 895

cacaggagcc cttggagttt at 22

<210> 896

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 896

ctgaaggcag acctaggaca ag 22

<210> 897

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 897

caactgctct ttagagatac acgctt 26

<210> 898

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 898

cggtccatcc aaggtaagag gt 22

<210> 899

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 899

gcccttagct gatctgacca tg 22

<210> 900

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 900

tgttctgatg gccatggtga tc 22

<210> 901

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 901

tgactacaga cccaaggatg ga 22

<210> 902

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 902

cagaaagact tcccagggaa gatg 24

<210> 903

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 903

gcatctcaga ctccttggca aaaa 24

<210> 904

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 904

tccacaggcc atcaatgctt t 21

<210> 905

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 905

gcctcaagat gtctcacatg gt 22

<210> 906

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 906

gcaagaatcg ggaaagactc ct 22

<210> 907

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 907

gaggattaat cagtgacagg aagct 25

<210> 908

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 908

aagttccctc atcctatgcc cta 23

<210> 909

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 909

ggcagtttct cacaaaggca tt 22

<210> 910

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 910

gctcaccaat ggctctcttc tc 22

<210> 911

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 911

atgggtctcc tgcttcctct aa 22

<210> 912

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 912

aggccatact ggtagtagct agtg 24

<210> 913

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 913

aaacttctgt atgctgtgga acctt 25

<210> 914

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 914

gtccctaaag gacttgattc gga 23

<210> 915

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 915

accgtggaag atgtcctgaa ga 22

<210> 916

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 916

ctgagcaggt agaagcagaa gca 23

<210> 917

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 917

tccagaatgc tctcatgatt tccc 24

<210> 918

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 918

agcaaatcag gatgaagcaa cct 23

<210> 919

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 919

tggacagcca tctggtagag aa 22

<210> 920

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 920

cccatctctt agtatgtgga gcaaga 26

<210> 921

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 921

ctgaagcgct caaacttcaa cc 22

<210> 922

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 922

ctggtgatag agtgaggaag agaga 25

<210> 923

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 923

cccaggtgga ttcttacaga ctc 23

<210> 924

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 924

gctaaccagc ctcagctcaa tg 22

<210> 925

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 925

cctcctgtgc actttgagca at 22

<210> 926

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 926

agaacgagtg gtcttcacaa cac 23

<210> 927

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 927

agtgcctgcc tctgacaaaa tt 22

<210> 928

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 928

tgggtgctca gtcagtagtc aa 22

<210> 929

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 929

agagatgcag agcttcctga ac 22

<210> 930

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 930

ccaagtcgct gaaattccca tg 22

<210> 931

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 931

tgatgtagag ctggaacaga ctct 24

<210> 932

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 932

ctcaagatcc acctcttctc catg 24

<210> 933

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 933

cccaggctca gctttgtgag 20

<210> 934

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 934

gtggattcca gcctaatccc t 21

<210> 935

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 935

ggagccaggt aggctgaaga 20

<210> 936

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 936

gtgtggtggt gaatgacatg ga 22

<210> 937

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 937

gtgacctcgt gggacacaa 19

<210> 938

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 938

tccagttcca actcatccat aagc 24

<210> 939

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 939

agaggtttga gaaggaagca gaga 24

<210> 940

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 940

gaagtttggc agggataggc ta 22

<210> 941

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 941

ctgaagagcc aggagatgct tta 23

<210> 942

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 942

cagcatcgag taccagtgga t 21

<210> 943

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 943

tgctacagac ctgctgaagt tc 22

<210> 944

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 944

aaactgctct cacagaacgg tt 22

<210> 945

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 945

ccactgacat ctttgcccag aa 22

<210> 946

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 946

tcagggagct tgaggtaacc t 21

<210> 947

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 947

ggccttcatc ttgcacatct gta 23

<210> 948

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 948

tgcagtctct tctcaggtca gt 22

<210> 949

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 949

cagggaagct gttctccgac 20

<210> 950

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 950

cgtgctggac tacgacacg 19

<210> 951

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 951

cacatggttg ggctcaggat 20

<210> 952

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 952

catggcgaga ggtgttggt 19

<210> 953

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 953

ctgctcactt gtggaagatc ttgt 24

<210> 954

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 954

ctcactgcct ctttgtcgac a 21

<210> 955

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 955

cacatccagc tgcaaactct tg 22

<210> 956

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 956

caagaaggac cttcacccat tgt 23

<210> 957

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 957

gcagaagtac ttccggatga gttc 24

<210> 958

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 958

ggacatgtta cccttgacag tga 23

<210> 959

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 959

accgcatcag ccgaatct 18

<210> 960

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 960

tgccaccgtc ctctttctg 19

<210> 961

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 961

cccaccaggg ttatcattgc tg 22

<210> 962

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 962

ctttctcaag agcgtctttg cttc 24

<210> 963

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 963

gaagccacag gattatgcaa agag 24

<210> 964

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 964

gaggagggtc ctgtagggat 20

<210> 965

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 965

acaggaactg gtatgcctgg ta 22

<210> 966

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 966

gccacctaga aactttctta gcaaaaa 27

<210> 967

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 967

cctcagagcc agaaggttct tg 22

<210> 968

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 968

gcacagagtc tcctggaaaa gg 22

<210> 969

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 969

accacagcag cttttctgag ag 22

<210> 970

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 970

ctcagcagcg acatctctac tc 22

<210> 971

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 971

tacccgagac cacagtgctc 20

<210> 972

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 972

ttgcgccagg ccatcaagat 20

<210> 973

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 973

ccctcctggt aactggagga aa 22

<210> 974

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 974

caggcagaaa ccacctctga g 21

<210> 975

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 975

ggatatccag aggcagcgtt 20

<210> 976

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 976

ataatttcca ccgctggttc ca 22

<210> 977

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 977

caggatgaag gtctcgtccc 20

<210> 978

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 978

tgatgagggc ctctcccagg 20

<210> 979

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 979

cctcgttgta cgtcttctgc a 21

<210> 980

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 980

gagtctgttc cagctctaca tcag 24

<210> 981

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 981

ttggccacct gcaaaggaaa gg 22

<210> 982

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 982

aagatcttcc acaagtgagc agatag 26

<210> 983

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 983

ggtggtagtg tggctgttct ag 22

<210> 984

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 984

gctgctctat gaatgaagga agga 24

<210> 985

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 985

tatgtagccg accctggaca tag 23

<210> 986

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 986

tgaagattgc cctgcaggta ac 22

<210> 987

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 987

cagcatccag tgtgcatgtt g 21

<210> 988

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 988

ctagggatgg gaagggaagg gat 23

<210> 989

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 989

ggtggaagtc ggataggtcc tt 22

<210> 990

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 990

cctcattgca gagagccact t 21

<210> 991

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 991

tgcactcact cctccaacaa tt 22

<210> 992

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 992

ctaaagcatc tcctggctct tca 23

<210> 993

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 993

actgcatgcc tacctgttct g 21

<210> 994

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 994

gttttcagcc tgtactggtg gat 23

<210> 995

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 995

cggaagggtg agggtttcac 20

<210> 996

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 996

aggtcagctt ctctcagggt t 21

<210> 997

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 997

cggtctgggt aggtctcagt 20

<210> 998

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 998

gctctgtgtc ctcacaaagc tg 22

<210> 999

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 999

aaggcctcgc cttccaggt 19

<210> 1000

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 1000

aacccatgtg ccgaggctg 19

<210> 1001

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1001

cccagggaga gaacatgctt tg 22

<210> 1002

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1002

gtctaaactc aggccctaag gaac 24

<210> 1003

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1003

acccataagg gaggtcacca aa 22

<210> 1004

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1004

gagctttgct acatgaacac caac 24

<210> 1005

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1005

tgcttcaggt ggaaccattc ag 22

<210> 1006

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1006

tcgacacagc tctttccatc ttg 23

<210> 1007

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1007

cgggacccac tcacaattca aa 22

<210> 1008

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1008

gcatttcctc cagttaccag ga 22

<210> 1009

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1009

cggtaggagg ccttgactgt 20

<210> 1010

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1010

cctcagctgt atgtgttccc a 21

<210> 1011

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1011

gctacagggc ttcttggaag tg 22

<210> 1012

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1012

tgtctgaagg caacagtgaa aca 23

<210> 1013

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1013

aggcatattt taagaggaca atggatttgt 30

<210> 1014

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1014

agggtggtgg ccattactag a 21

<210> 1015

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1015

ctggagcctc atctttggca 20

<210> 1016

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1016

ggctgcaatg tctctaccac atc 23

<210> 1017

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1017

gggatcctgt agatctctga ctct 24

<210> 1018

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1018

cagccaccct ccctaaaact tc 22

<210> 1019

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 1019

gtgcagcgga gggagttga 19

<210> 1020

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1020

catacccttg gcctggatca 20

<210> 1021

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 1021

cgggcaactt gccgatca 18

<210> 1022

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1022

ctcttcaggc cagaaggacc aa 22

<210> 1023

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1023

tcttgttctg tcccatctga ccta 24

<210> 1024

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1024

caggtcatca cccagacact 20

<210> 1025

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1025

ccaggttacc tcaagctccc t 21

<210> 1026

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1026

cgcactctac actgtcttgc a 21

<210> 1027

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 1027

gaaagccctt gcaagtccc 19

<210> 1028

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1028

ccacacactc ttctctgcca c 21

<210> 1029

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1029

gtcttgtttt aagctgtgag attttcatgt 30

<210> 1030

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1030

cccactgcat gctatccaac tt 22

<210> 1031

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1031

aaacaatatt catttaactc attcacttga gg 32

<210> 1032

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1032

gctctcatct ttaaagccca tcatacattt att 33

<210> 1033

<211> 18

<212> DNA

<213> Rabbit calicivirus

<400> 1033

actctgcctc gcaagcag 18

<210> 1034

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1034

ccgcgaaacc agtcactact aaaaa 25

<210> 1035

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1035

ggttgcaagg gcctcatttt t 21

<210> 1036

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1036

gtcagggcct caaagagaca c 21

<210> 1037

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1037

cgaggaaccc tgccatgtat ag 22

<210> 1038

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1038

acagcatcag attcacttcg aatattaaga 30

<210> 1039

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1039

actagaagaa ttggtaaata tgcttgttaa ct 32

<210> 1040

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1040

ggccaatatg gtaaaactcc gtct 24

<210> 1041

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1041

tttcagatga taccatcttc caaaatcct 29

<210> 1042

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1042

gcataccttt ctgtaatgaa gtctgactt 29

<210> 1043

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1043

aattttccaa gtggtagtcc tgtttca 27

<210> 1044

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1044

aatttgtaga ctgcgtggca ctat 24

<210> 1045

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1045

aaggattcat ccttaatcct tgctagtt 28

<210> 1046

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1046

ctacaagcag tgtacaaaca tgcttc 26

<210> 1047

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1047

ctctacctac atttgttttc ttggctagta 30

<210> 1048

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1048

ccctggacgt tctatgaagc attttta 27

<210> 1049

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1049

tcctgacctc aagagatcca ctc 23

<210> 1050

<211> 19

<212> DNA

<213> Rabbit calicivirus

<400> 1050

gtggcagaca gtgcaaagg 19

<210> 1051

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1051

gttttccagg acacttcact tcca 24

<210> 1052

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1052

acttgttagc cacatcagcg tt 22

<210> 1053

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1053

gtttgaacta taaaaagcac cggatctt 28

<210> 1054

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1054

gacaatgctt ttgatcagca gactaaatta 30

<210> 1055

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1055

ccctttgatt acgggctaag gtag 24

<210> 1056

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1056

cccattcaac acctgtgtaa tca 23

<210> 1057

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1057

ggtagcagtt tattcatctg tgaaaggaaa 30

<210> 1058

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1058

atcttatcta tgagaaacac caaaaactat ga 32

<210> 1059

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1059

gtcaatacaa atgttagcca ggcg 24

<210> 1060

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1060

agaaagctca actaaatttg agaagaataa tct 33

<210> 1061

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1061

tcagtttgac tcatacagtt aacacaatgt 30

<210> 1062

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1062

ccagtcaggg ctctgctact aa 22

<210> 1063

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1063

catatatagc cagcccttca tatctgtg 28

<210> 1064

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1064

tgcaccaacc ttaatgctat gtaaatagtt 30

<210> 1065

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1065

attgtattag gtattaaagt catctggaca tg 32

<210> 1066

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1066

ttcatcacat actttattta ttctgagaca agg 33

<210> 1067

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1067

taagcgtcct caggtcctag gg 22

<210> 1068

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1068

agtcgctcta gtagctggga c 21

<210> 1069

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1069

aaatgctaca ttaatgtttg ggtggtc 27

<210> 1070

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1070

acaattagat cagtcagtca ggttaaaata taa 33

<210> 1071

<211> 17

<212> DNA

<213> Rabbit calicivirus

<400> 1071

ttggaccgag ccgatcg 17

<210> 1072

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1072

ctgaagtcac ccacccaccc a 21

<210> 1073

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1073

aaaaatgtac atggcagtgt tttagttg 28

<210> 1074

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1074

agtatgatgc ttcttattct tagtctatgg ttt 33

<210> 1075

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1075

ttcttttaaa gttataaaca cgtacttgtg cg 32

<210> 1076

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1076

cccgaagaga aaccacattt aaca 24

<210> 1077

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1077

gtattttgct gatttaaagg cttaggcat 29

<210> 1078

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1078

ttttcatcca caaagcagga aaaacat 27

<210> 1079

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1079

tttctgtgtg gaaaactaag aaaattgctt 30

<210> 1080

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1080

gttacattgc agtattttta agagggtgat 30

<210> 1081

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1081

gggctcaata aatgttttca atgaatttaa ac 32

<210> 1082

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1082

tttttgcttg aaagtaatga ctgtgtag 28

<210> 1083

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1083

attagataat cttatgactt ccttctagct cca 33

<210> 1084

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1084

ttggcagtta aattaaaagg atagttaaca agc 33

<210> 1085

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1085

cttcccaaag cagctttgct tt 22

<210> 1086

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1086

gtgatttata gttgctccca gatatctgaa 30

<210> 1087

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1087

tttaacctta aaatgacagt gggataggg 29

<210> 1088

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1088

ataaattata tgagacttac cagacactcc tca 33

<210> 1089

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1089

aacaaaagtc tgttgcttgt gtttca 26

<210> 1090

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1090

tatctccttc accagtataa agaaaccct 29

<210> 1091

<211> 31

<212> DNA

<213> Rabbit calicivirus

<400> 1091

tgcaagacct tgtctcagaa taaataaagt a 31

<210> 1092

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1092

taactgggca ccgtggagca t 21

<210> 1093

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1093

gggaaaaacc atccttaagg ctga 24

<210> 1094

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1094

ccgccatttt tcaacttacc acttg 25

<210> 1095

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1095

cgtggacaca cttcgggttt 20

<210> 1096

<211> 23

<212> DNA

<213> Rabbit calicivirus

<400> 1096

gggaaagcct acacaagctg tac 23

<210> 1097

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1097

ccaaattgca gatttatcaa cggctt 26

<210> 1098

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1098

tggccagttc tgaaaggact ttaatc 26

<210> 1099

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1099

gatctagtga atgctcagaa agacagtatg 30

<210> 1100

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1100

ctaacacaca gcattaaggt tacgtttaaa 30

<210> 1101

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1101

cgacactttc ctaattgctt ctttgtt 27

<210> 1102

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1102

cctggcatac ttgggaagct at 22

<210> 1103

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1103

gaaaatggga agcaatattt gacatagttc tt 32

<210> 1104

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1104

cttgagctct tgcaaccttg taag 24

<210> 1105

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1105

taaccttttt ggtgccaatg tgaaatg 27

<210> 1106

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1106

cttttagtaa agtgacttag gcaggctta 29

<210> 1107

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1107

actcagtatt ttaaacatct gtcagcttat gt 32

<210> 1108

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1108

gttttaagga tcttgagaga acatttattt cag 33

<210> 1109

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1109

aaaaacactt gaataagaat cagtagggta ta 32

<210> 1110

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1110

gtagtaatca acagaagtta ggagaacata aca 33

<210> 1111

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1111

gccctgtttc tgttttagta tgtaaatcc 29

<210> 1112

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1112

gtccttggct aacaactaga ttgaacta 28

<210> 1113

<211> 27

<212> DNA

<213> Rabbit calicivirus

<400> 1113

tttttcttcc tctccatgag ttgtgaa 27

<210> 1114

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1114

ctttgcaaat gatcaatttt tgcgga 26

<210> 1115

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1115

catgcaaaga ttcaagtagt tttgcaataa 30

<210> 1116

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1116

ggccaaatca cattatatac actcactaca 30

<210> 1117

<211> 20

<212> DNA

<213> Rabbit calicivirus

<400> 1117

ttgtggtgag cgaagatcgt 20

<210> 1118

<211> 21

<212> DNA

<213> Rabbit calicivirus

<400> 1118

cagagtagct gcgactatgg g 21

<210> 1119

<211> 30

<212> DNA

<213> Rabbit calicivirus

<400> 1119

cccatctcta aataaatagg tcaaaccctt 30

<210> 1120

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1120

cctgtcattc tataactctg ttatgctga 29

<210> 1121

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1121

actcaaaggt gatgtaattt gtgcaaag 28

<210> 1122

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1122

caattcctcc ttggttgaat ccatg 25

<210> 1123

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1123

agccaaaatt gtcatactgt tgttaagc 28

<210> 1124

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1124

cttttgtcca ggctggcatc atata 25

<210> 1125

<211> 24

<212> DNA

<213> Rabbit calicivirus

<400> 1125

caagtgattc atctcccaaa gtgc 24

<210> 1126

<211> 25

<212> DNA

<213> Rabbit calicivirus

<400> 1126

ccttagataa aatcacacaa ggccg 25

<210> 1127

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1127

ctgaaaccct gtctgtacaa aaatacaaa 29

<210> 1128

<211> 28

<212> DNA

<213> Rabbit calicivirus

<400> 1128

taggcatatc tgcaaacttc agattcaa 28

<210> 1129

<211> 22

<212> DNA

<213> Rabbit calicivirus

<400> 1129

tgtgctgaag cagttgacaa gt 22

<210> 1130

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1130

cagctaatac cctgaaaaat caagaaattc aaa 33

<210> 1131

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1131

ggagctttct gtatataaat gtggagatta gag 33

<210> 1132

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1132

tacgctttca aaaatggcaa atcacttta 29

<210> 1133

<211> 33

<212> DNA

<213> Rabbit calicivirus

<400> 1133

gcatagaaca aaagatttgg aaagatatac acc 33

<210> 1134

<211> 29

<212> DNA

<213> Rabbit calicivirus

<400> 1134

actaaagctg agtgataagt agttttgca 29

<210> 1135

<211> 26

<212> DNA

<213> Rabbit calicivirus

<400> 1135

tgcagttttg gtttgatgta acaagg 26

<210> 1136

<211> 32

<212> DNA

<213> Rabbit calicivirus

<400> 1136

agtactctgt ctcaaaacat ttcacatgat ta 32

Claims (6)

1. a kind of kit for detecting relevant 411 mutational sites of primary Hemophagocytic Lymphohistiocytosis, It is characterized by:

The kit includes the reagent for detecting 411 mutational sites；

411 mutational sites be located at PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, CD27, MAGT1, RAB27A, LYST, AP3B1, BLOC1S6, TCN2, IL2RG totally 15 genes；

411 mutational sites are as follows:

The reagent includes the multiple PCR primer for expanding 411 above-mentioned mutational sites:

2. kit according to claim 1, which is characterized in that the kit further includes that genomic DNA is made For the reagent in the library of sequencing.

3. kit according to claim 1, which is characterized in that the kit further includes the examination for the sequencing of two generations Agent.

4. kit according to claim 1, which is characterized in that the kit further include dNTP, archaeal dna polymerase, Reagent, positive control and/or negative control for isolated or purified nucleic acid.

5. kit according to claim 4, which is characterized in that detection sample used is peripheral blood, marrow or entity Tissue samples.

6. kit according to claim 4, which is characterized in that detection sample used is peripheral blood.