CN109550093A - Cell membrane artificial liver - Google Patents
Cell membrane artificial liver Download PDFInfo
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- CN109550093A CN109550093A CN201710916977.1A CN201710916977A CN109550093A CN 109550093 A CN109550093 A CN 109550093A CN 201710916977 A CN201710916977 A CN 201710916977A CN 109550093 A CN109550093 A CN 109550093A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
- A61M1/3689—Chemical treatment by biological cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/369—Temperature treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1071—Liver; Hepar
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of cell membrane artificial livers, including, closed shell, physiological saline is filled in closed housing body, immersed with liver function core in physiological saline, liver function core blood inlet is connected by the first opening on the second conduit and closed shell, and the first electronic valve is housed on the second conduit, the first opening arterial blood pump external with closed housing communicates, and arterial blood pump is communicated by the first conduit with the arteries of patient's body.Liver function core blood outlet is open by the third on third conduit and closed shell and is connected, and the second electronic valve is housed, third opening and the 4th external conduit of closed housing are logical, and the 4th conduit is communicated with the vein blood vessel of patient's body on third conduit.The second opening is provided on closed shell, the second opening hydraulic pump external with closed housing communicates.Temperature controller is housed outside closed shell upper casing wall.
Description
Technical field
The present invention is a kind of Medical Instruments, especially a kind of man-made organ.
Background technique
Temporarily without similar technique.
Summary of the invention
The present invention is combined using function liver cell with mechanical structure, the main Physiological Function of Lai Shixian liver, and is passed through
The circulation of blood plays physiological action instead of liver in vitro.
The technical scheme adopted by the invention is that: by the combination of function liver cell and mechanical structure, Lai Shixian liver
Physiological function.Including, closed shell, physiological saline is filled in closed housing body, immersed with liver function core, liver function in physiological saline
Energy core blood inlet is connected by the first opening on the second conduit and closed shell, equipped with the first electronic valve on the second conduit
Door, the first opening arterial blood pump external with closed housing communicate, and arterial blood pump passes through the arterial blood of the first conduit and patient's body
Pipe communicates.Liver function core blood outlet is open by the third on third conduit and closed shell and is connected, and is equipped on third conduit
Second electronic valve, third opening and the 4th external conduit of closed housing are logical, the vein blood vessel phase of the 4th conduit and patient's body
It is logical.The second opening is provided on closed shell, the second opening hydraulic pump external with closed housing communicates.Closed shell upper casing wall exterior
There is temperature controller.
Above-mentioned cell membrane artificial liver, its effect of first conduit is by the arterial blood of patient by patient's body water conservancy diversion
To arterial blood pump.First catheter opening is connected with the arteries of patient's body, and end is connected with arterial blood pump storage blood vessel
It is logical.
Above-mentioned cell membrane artificial liver, its effect of the arterial blood pump is first to cache arterial blood, then quantitative, level pressure
The feeding artery blood into liver function core.Quantitative, level pressure the purpose of feeding artery blood into liver function core is to allow liver
The arterial blood of equivalent equipressure is all obtained per a piece of liver function blade in function core, with the liver function blade that prevents because of blood
Amount, the unevenness of blood pressure and cannot get enough arterial bloods and the situation of necrosis.The structure of arterial blood pump is to store up blood vessel, piston, electricity
Motivation.Workflow is that arterial blood flows into arterial blood pump by the first conduit and stores up blood vessel, when artery blood volume reaches certain numerical value,
Motor start-up pushes piston, arterial blood is pushed into the second conduit, and enter liver function core by the second conduit.
Above-mentioned cell membrane artificial liver, its effect of second conduit are that the arterial blood for releasing arterial blood pump is guided to
Liver function core.One end of second conduit is open by closed shell first to be connected with the storage blood vessel of arterial blood pump, the other end
It is connected with the blood inlet of liver function core.
Above-mentioned cell membrane artificial liver, first electronic valve are mounted on the second conduit, and effect is control the
The conducting of two conduits and obstruction.When the first electronic valve is closed, the second conduit is blocked state, and arterial blood can not pass through second
Conduit.The arterial blood come out from patient's body water conservancy diversion can only flow into the storage blood vessel of arterial blood pump, without passing through the second conduit stream
Enter in liver function core.After arterial blood pump storage blood vessel stores up full arterial blood, the first electronic valve is opened, and the second conduit is conducting
State, the arterial blood that arterial blood pump is released, will be entered in liver function core by the second conduit.
Above-mentioned cell membrane artificial liver, its effect of the liver function core is to realize the physiological function of liver, to artery
Blood carries out biochemical treatment.Its structure is rectangular retaining frame, and the right hand external of fixed frame is fixed with the 5th conduit, the 5th
Tube at one end opening, other end closing.The left hand external of fixed frame is fixed with the 6th conduit, and the 6th tube at one end is open, separately
It is closed at one end.The open end and closed end of 5th conduit are contrary with the open end of the 6th conduit and closed end.5th conduit
Open end be connected with one end of the second conduit, the open end of the 6th conduit is connected with one end of third conduit.The 5th
On the conduit conduit side opposite with the 6th conduit, some osculums are respectively oppositely equidistantly opened.Rectangular retaining frame
The liver function blade of internal equidistant some quadrangles of fixation, four angles of these quadrangle liver function blades are fixed on fixation
On four sheths of frame, it is parallel to each other each other.Blood inlet and the 5th conduit side on the right side of each liver function blade
On an opening in communication, the blood outlet on the left of each liver function blade is connected with an opening on the 6th conduit side
It is logical.The workflow of liver function core is that the arterial blood come from the second conduit stream enters the 5th by the open end of the 5th conduit
Then conduit is flowed into per a piece of liver function blade by the opening on the 5th conduit side, arterial blood is in liver function blade
After processed, become venous blood, the blood outlet on the left of liver function blade is then flowed under extraneous pressure effect, then lead to
The opening crossed on the 6th conduit side flows into the 6th conduit, flows into third conduit from the open end of the 6th conduit.
Above-mentioned liver function core, its effect of the liver function blade is the most basic list for realizing liver physiology function
Member.Its structure is that the rectangular organic material film of two panels is affixed bonding, and accompanies one between the two panels organic material film of bonding
The function liver cell diaphragm of layer disc-shaped.(black region is bonding to the bonding mode of two panels organic material film in figure as shown in Figure 4
Region), unbonded place is formed respectively into blood channel, bleeding channel and the central blister for accommodating function liver cell diaphragm
Area.Arterial blood is flowed by the blood inlet of liver function blade into blood channel, and by flowing into central blister area into blood channel, arterial blood is filled
After full center blister area, just function liver cell diaphragm is wrapped in wherein, the function liver cell with function liver plasma membrane on piece
It comes into full contact with, and is handled by function liver cell.After being disposed by function liver cell, become the blood of venous blood in ambient pressure
Under the action of, bleeding channel is flowed by central blister area, then passes through the blood outlet of liver function blade, flows out liver function blade.
Above-mentioned liver function blade, its effect of the function liver cell diaphragm is the physiology function for functioning liver cell
Can, biochemical treatment directly is carried out to arterial blood.Its structure is that the organic material support plate of disc-shaped, support plate both ends are extended
Carry out two end handles.Using 3D cell printing technology, about 1 millimeter of a thickness of function liver cell is printed on the disk of support plate
(function liver cell is to be formed in advance with the epithelial cell Fiber differentiation of patient) forms one layer of function of being wrapped in support plate disk
Hepatocyte cell film.Then entire function liver cell diaphragm is adhesively fixed by the end handle at support plate both ends in liver function blade
Two panels organic material film on piece.It after function liver plasma membrane in support plate is wrapped up by arterial blood, is come into full contact with arterial blood, to dynamic
Arteries and veins blood carries out biochemical treatment, plays the physiological function of liver cell.Obtain nutrition from arterial blood simultaneously, and by waste discharge to moving
In arteries and veins blood, metabolism is realized, maintains the physiological activity of oneself.
Above-mentioned cell membrane artificial liver, its effect of the third conduit is the venous blood that liver function core is disposed
Import the 4th conduit.Third tube at one end is connected with the open end of the 6th conduit, and the other end is connected with the 4th conduit, third
Second electronic valve is installed on conduit.
Above-mentioned cell membrane artificial liver, its effect of second electronic valve is to control the conducting and resistance of third conduit
Plug.When the second electronic valve is closed, third conduit is blocked state, and blood can not be flowed out out of liver function core, when second
When electronic valve is opened, third conduit is not turned on, and blood can be flowed out from liver function core, is flowed into the 4th by third conduit and is led
Pipe, is finally flowed back in Venous Blood pipe.When the second electronic valve is closed, moving blood just can be under the effect of the pressure by liver function
The central blister area of energy blade is completely filled with, could be fully wrapped around by the function liver cell diaphragm in central blister area, and
Biochemical hair occurs with function liver cell diaphragm to answer, it, can not be with function liver cell without directly from the interior outflow of liver function blade
The sufficient haptoreaction of diaphragm.
Above-mentioned cell membrane artificial liver, its effect of the 4th conduit is the venous blood for finishing liver function core processing
It imports in Venous Blood pipe.4th tube at one end is connected with third conduit, and one end is connected with the vein blood vessel of patient's body
It is logical.
Above-mentioned cell membrane artificial liver, its effect of the hydraulic pump are by the promotion of piston and by physiological saline
Transmitting effect passes to pressure on liver function blade.It will be disposed in liver function blade blister area by function liver cell diaphragm
Venous blood squeeze out liver function blade, realize the circulation of workflow.Its mechanism is liquid storage pipe, piston, motor.Liquid storage pipe
It is connected by the second opening on closed shell with closed enclosure interior space.Pressure can pass through the life in hydraulic pump liquid storage pipe
Manage salt water
The intracorporal physiological saline of closed housing is passed to, liver function blade is ultimately transferred to.
Above-mentioned cell membrane artificial liver, its effect of the temperature controller are to maintain the intracorporal temperature of closed housing and human body
Normal body temperature is consistent, and cryogenic temperature condensation occurs in whole equipment to prevent Hemostatic Oral Liquid, and maintain the function on function liver plasma membrane
It can liver cell holding physiological activity.Temperature passes to the intracorporal physiological saline of closed housing by closed housing wall, then passes through life
Reason salt water reaches entire inner space.
Above-mentioned cell membrane artificial liver, the effect of the physiological saline are pressure, the temperature etc. for generating external equipment
Control factors pass to workpiece.
The workflow of whole equipment is that the first electronic valve first and the second electronic valve are closed, and arterial blood is by patient
Intracorporal arteries flows into the first conduit, and the storage for flowing into arterial blood pump from the first conduit is intravascular, intravascular full of dynamic when storing up
When arteries and veins blood, the first electronic valve is opened, then the motor start-up of arterial blood pump, arterial blood is pushed into the second conduit, through second
Conduit flows into liver function core.Arterial blood stops the of short duration time in liver function core, is disposed by liver function core
After becoming venous blood, the first electronic valve is closed, and the second electronic valve is opened, then hydraulic pump startup, and hydraulic pump pushes physiology
Pressure is passed to liver function core by salt water, and the venous blood being disposed in liver function core is squeezed into the 6th conduit, venous blood
Third conduit is flowed by the 6th conduit, then flows into the 4th conduit from third conduit, flows back to patient's body finally by the 4th conduit
Interior vein blood vessel.After venous blood all flows into patient's body, the second electronic valve is closed, and completes entire workflow.
The invention has the advantages that passing through the combination of function liver cell and mechanical structure, instead of Liver Tissue
Complicated structure, while by the expanding-contracting type blood way of propelling of simulation heart, realize blood following in present device
Circulation is dynamic.(mutual cooperation of arterial blood pump and hydraulic pump makes liver function core generate the blood flow mode of expanding-contracting type.) function
From nutrition is obtained in arterial blood and by waste discharge into blood while liver cell is to arterial blood progress biochemical treatment, maintain
The physiological activity of oneself.In summary factor, the present invention realize the physiological function of liver, and realize the effect of sustainable work
Fruit can replace human liver and carry out long-term treatment to patient in vitro.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is schematic diagram of the present invention；
Fig. 2 is liver function core structural schematic diagram；
Fig. 3 is liver function core fixed frame structural scheme of mechanism；
Fig. 4 is liver function blade construction schematic diagram；
Fig. 5 is function liver plasma membrane chip architecture schematic diagram；
Fig. 6 is liver function blade working flow diagram；
1. closed shell in figure, 2. physiological saline, 3. liver function cores, 4. liver function core blood inlets, 5. second conduits,
6. the first electronic valve, 7. closed housing walls first are open, 8. arterial blood pumps, and 9. arterial blood pumps store up blood vessel, and 10. arterial blood pumps are living
Plug, 11. arterial blood pump motor, 12. first conduits, 13, liver function core blood outlet, 14. third conduits, 15. second electronics
Valve, 16. closed housing walls second are open, 17. the 4th conduits, 18. closed housing wall third openings, 19. hydraulic pump pistons,
20. hydraulic pump, 21. hydraulic pump motors, 22. temperature controllers, 23. liver function blades, 24. liver function core fixed frames,
25. arterial blood, 26. the 5th conduits, 27. the 6th conduits, 28. hydraulic pump liquid storage pipes, 29. the 5th catheter lock ends, 30. the 5th lead
Tube opening end, 31. the 5th duct walls opening, 32. the 6th catheter lock ends, 33. the 6th catheter opening ends, 34. the 6th conduits
Sidewall opening, 35. liver function blade blood inlets, 36. liver function blade blood outlets, 37. liver function blades are into blood channel, 38. livers
Functional leaf bleeding channel, 39. function liver cell diaphragms, 40. function liver cell diaphragm fixing end handles, 41, in liver function blade
Entreat blister area, 42. organic material films, 43. function liver cell diaphragm support plates, 44.3D printing function liver plasma membrane, 45. liver functions
Can diaphragm work original state, 46. arterial bloods arterial blood pump pressure effect under enter liver function central vane blister area, 47.
Arterial blood is reacted with function liver plasma membrane, and the pressure that 48. venous blood are come by hydraulic pump transmitting squeezes out liver function blade, 49. liver functions
Energy blade restPoses, 50. venous blood.
Specific embodiment
[embodiment 1]
Cell membrane artificial liver includes closed shell 1, fills physiological saline 2 in closed shell 1, impregnates in physiological saline 2
There is liver function core 3, liver function core blood inlet 4 is connect by the second conduit 5 with the first opening 7 on closed shell, and second
First electronic valve 6 is housed, the first 7 arterial blood pumps 8 external with closed housing of opening communicate, and arterial blood pump stores up blood vessel 9 on conduit 5
It is communicated by the first conduit 12 with the arteries of patient's body.Liver function core blood outlet 13 by third conduit 14 with it is closed
Third opening 18 on shell 1 connects, and the second electronic valve 15, third opening 18 and closed shell 1 are housed on third conduit 14
The 4th outer conduit logical 17, the 4th conduit 17 is communicated with the vein blood vessel of patient's body.The second opening is provided on closed shell 1
16, the second opening hydraulic pump 20 external with closed housing communicates.Shell wall exterior has temperature controller 22 on closed shell 1.Liver function
Multi-disc liver function blade 23, liver function blade blood inlet 35 and 26 side of the 5th conduit can be fixed in parallel on core fixed frame 24
The opening 31 in face is connected, and liver function blade blood outlet 36 is connected with the opening 34 of 27 side of the 6th conduit.
When the invention works, the first electronic valve 6 first and the second electronic valve 15 are closed, and arterial blood 25 is by patient's body
Arteries flow into the first conduit 12, from the first conduit 12 flow into arterial blood pump 8 storage blood vessel 9 in, when storage blood vessel 9 in be full of
When arterial blood 25, the first electronic valve 6 is opened, and then the motor 11 of arterial blood pump 8 starts, and the push-in of arterial blood 25 second is led
Pipe 5 flows into the 5th conduit 26 through the second conduit 5, then flows into liver function blade blood inlet by the 5th conduit side opening 31
35, enter liver function central vane blister area 41 into blood channel 37 by liver function blade.Arterial blood is full of in liver function blade
After entreating blister area 41, wherein by the package of function liver cell diaphragm 39, the function liver cell on function liver cell diaphragm 39 is to dynamic
Arteries and veins blood carries out biochemical treatment.After blood is processed, the first electronic valve 6 is closed, and the second electronic valve 15 is opened, then liquid
Press pump 20 starts.Physiological saline 2 in liquid storage pipe 28 is passed through 8 push-in of the second opening on closed housing wall by hydraulic pump piston 19
In closed shell 1, pressure is passed in every a piece of 23. liver function blade 23 of liver function blade in liver function core 3 and is located
The venous blood finished is managed by the pressure extrusion of extraneous physiological saline 2, the 6th conduit 27 is flowed by liver function blade blood outlet 36
Then side opening 34 flows into third conduit 14 by the 6th conduit, then flows into the 4th by closed housing wall third opening 16
Conduit 17 flows back to the vein blood vessel of patient's body finally by the 4th conduit 17.After venous blood all flows into patient's body,
Second electronic valve 15 is closed, and entire workflow is completed.
Claims (3)
1. a kind of cell membrane artificial liver, it is characterised in that: fill physiological saline 2 in closed shell 1, impregnated in physiological saline 2
There is liver function core 3, liver function core blood inlet 4 is connect by the second conduit 5 with the first opening 7 on closed shell, and second
First electronic valve 6 is housed, the first 7 arterial blood pumps 8 external with closed housing of opening communicate, and arterial blood pump stores up blood vessel 9 on conduit 5
It is communicated by the first conduit 12 with the arteries of patient's body.Liver function core blood outlet 13 by third conduit 14 with it is closed
Third opening 18 on shell 1 connects, and the second electronic valve 15, third opening 18 and closed shell 1 are housed on third conduit 14
The 4th outer conduit logical 17, the 4th conduit 17 is communicated with the vein blood vessel of patient's body.The second opening is provided on closed shell 1
16, the second opening hydraulic pump 20 external with closed housing communicates.Shell wall exterior has temperature controller 22 on closed shell 1.Liver function
Multi-disc liver function blade 23, liver function blade blood inlet 35 and 26 side of the 5th conduit can be fixed in parallel on core fixed frame 24
The opening 31 in face is connected, and liver function blade blood outlet 36 is connected with the opening 34 of 27 side of the 6th conduit.
2. cell membrane artificial liver according to claim 1, which is characterized in that the function liver cell diaphragm 39, to utilize
3D cell printing technology prints a layer function liver plasma membrane in support plate 43.
3. cell membrane artificial liver according to claim 1, which is characterized in that described its structure of liver function blade 23 is two
The rectangular organic material film 42 of piece is affixed bonding, and the function of one layer of disc-shaped is accompanied between the two panels organic material film of bonding
It can liver cell diaphragm 39.The bonding mode of two panels organic material film as shown in Figure 4 (black region is adhesion area in figure), does not glue
The place of conjunction is formed respectively into blood channel 37, bleeding channel 38 and the central blister area 41 for accommodating function liver cell diaphragm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710916977.1A CN109550093A (en) | 2017-09-23 | 2017-09-23 | Cell membrane artificial liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710916977.1A CN109550093A (en) | 2017-09-23 | 2017-09-23 | Cell membrane artificial liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109550093A true CN109550093A (en) | 2019-04-02 |
Family
ID=65864212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710916977.1A Pending CN109550093A (en) | 2017-09-23 | 2017-09-23 | Cell membrane artificial liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109550093A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006467A1 (en) * | 1985-12-02 | 1988-09-07 | Viles Joseph M | Liver assist device employing transformed cell lines |
| US20020168758A1 (en) * | 2001-05-11 | 2002-11-14 | Martinez F. Jesus | Bioreactor with application as blood therapy device |
| JP2004166717A (en) * | 1999-08-25 | 2004-06-17 | Toyobo Co Ltd | Module for cell culture having vascular plexus-like structure |
| CN105861419A (en) * | 2016-04-22 | 2016-08-17 | 毛雷 | Bioartificial liver based on three-dimensional cell printing, and preparation method and application of bioartificial liver |
-
2017
- 2017-09-23 CN CN201710916977.1A patent/CN109550093A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006467A1 (en) * | 1985-12-02 | 1988-09-07 | Viles Joseph M | Liver assist device employing transformed cell lines |
| JP2004166717A (en) * | 1999-08-25 | 2004-06-17 | Toyobo Co Ltd | Module for cell culture having vascular plexus-like structure |
| US20020168758A1 (en) * | 2001-05-11 | 2002-11-14 | Martinez F. Jesus | Bioreactor with application as blood therapy device |
| CN105861419A (en) * | 2016-04-22 | 2016-08-17 | 毛雷 | Bioartificial liver based on three-dimensional cell printing, and preparation method and application of bioartificial liver |
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