CN109550059A - A kind of glucose reagent of screening for diabetes and preparation method thereof - Google Patents
A kind of glucose reagent of screening for diabetes and preparation method thereof Download PDFInfo
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- CN109550059A CN109550059A CN201811614895.2A CN201811614895A CN109550059A CN 109550059 A CN109550059 A CN 109550059A CN 201811614895 A CN201811614895 A CN 201811614895A CN 109550059 A CN109550059 A CN 109550059A
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- diabetes
- screening
- reagent
- vitamin
- methoxyphenoxy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Rheumatology (AREA)
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- Urology & Nephrology (AREA)
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Abstract
The present invention discloses a kind of glucose reagent and preparation method thereof of screening for diabetes, raw material including following parts by weight proportion: Dextrose Monohydrate 80.5-83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10-0.13 g, vitamin C 0.04-0.08g and folic acid 0.0002-0.0006g, the glucose reagent of the screening for diabetes are relatively easy to entrance.
Description
Technical field
The present invention relates to glucose reagents of a kind of screening for diabetes and preparation method thereof.
Background technique
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction." sugar sieve " is the abbreviation of screen method for gestational diabetes, and sugar sieve is high-risk
Generally doctor can suggest continuing to do the resistance to inspection of sugar, and to make a definite diagnosis, whether there is or not pregnancy associated with diabetess.Sugar sieve serious person can threaten mother and baby's
Life security.
Current glucose reagent causes to be difficult to entrance due to too sweet tea.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of examinations of the glucose of screening for diabetes for being relatively easy to entrance
Agent and preparation method thereof.
To solve the above problems, the present invention adopts the following technical scheme:
A kind of glucose reagent of screening for diabetes, the raw material including following parts by weight proportion: Dextrose Monohydrate 80.5-
83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10-0.13 g, vitamin C 0.04-0.08g and folic acid 0.0002-
0.0006g。
Further, the raw material including following parts by weight proportion: Dextrose Monohydrate 80.5g, 2- (4- methoxybenzene oxygen
Base)-sodium propionate 0.10g, vitamin C 0.04g and folic acid 0.0002g.
Further, the raw material including following parts by weight proportion: Dextrose Monohydrate 83.5g, 2- (4- methoxybenzene oxygen
Base)-sodium propionate 0.13g, vitamin C 0.08g and folic acid 0.0006g.
Further, the raw material including following parts by weight proportion: Dextrose Monohydrate 82.5g, 2- (4- methoxybenzene oxygen
Base)-sodium propionate 0.12g, vitamin C 0.06g and folic acid 0.0004g.
Another technical problem to be solved by the present invention is that providing a kind of preparation side of the glucose reagent of screening for diabetes
Method, comprising the following steps:
1) by Dextrose Monohydrate 80.5-83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10-0.13 g, vitamin C
0.04-0.08g and folic acid 0.0002-0.0006g are poured into three-dimensional mixer together；
2) the three-dimensional mixed dynamic mixing machine of starting is that 10-12r/min carries out mixed processing, incorporation time 10- with the speed of mainshaft
20min is to get reagent.
The beneficial effects of the present invention are: by the way that 2- (4- methoxyphenoxy)-sodium propionate is added as suppression edulcorant, Ke Yiyou
The improvement mouthfeel of effect, allows reagent to be easier entrance.
The characteristics of being the raw material of the glucose reagent of screening for diabetes below or effect:
Dextrose Monohydrate: can be used as nutrient solution and be made into oral solution or intravenous fluid in pharmaceutical industries, be white particle sprills,
It is sweet.
2- (4- methoxyphenoxy)-sodium propionate: being the colourless crystalline solid in evaporated milk oil colours, and the sweet taste of sweetener inhibits
Agent can effectively improve mouthfeel, prevented sweet tea and reagent is caused to be difficult to entrance.
Vitamin C: structure is a kind of polyol similar to glucose, and as nutritional supplement, tool is compounded with folic acid
There is concertedness effect, is conducive to the metabolism of folic acid.
Folic acid: being a kind ofIt is water-solubleVitamin, pregnant woman is 4 times higher than normal person to the demand of folic acid, as nutritional supplementation
Agent.
Specific embodiment
Technical solution of the present invention is described below, it is clear that described embodiment is only present invention a part
Embodiment, instead of all the embodiments, to those skilled in the art, in the premise not made the creative labor
Under, other embodiments can also be obtained according to these embodiments.
Embodiment 1:
A kind of glucose reagent of screening for diabetes, the raw material including following parts by weight proportion: Dextrose Monohydrate 80.5g,
2- (4- methoxyphenoxy)-sodium propionate 0.10g, vitamin C 0.04g and folic acid 0.0002g.
A kind of preparation method of the glucose reagent of screening for diabetes the following steps are included:
1) by Dextrose Monohydrate 80.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10g, vitamin C 0.04g and folic acid
0.0002g is poured into three-dimensional mixer together；
2) the three-dimensional mixed dynamic mixing machine of starting is that 10r/min carries out mixed processing with the speed of mainshaft, incorporation time be 10min to get
Reagent.
Embodiment 2:
A kind of glucose reagent of screening for diabetes, the raw material including following parts by weight proportion: Dextrose Monohydrate 83.5g,
2- (4- methoxyphenoxy)-sodium propionate 0.13g, vitamin C 0.08g and folic acid 0.0006g.
A kind of preparation method of the glucose reagent of screening for diabetes, comprising the following steps:
1) by Dextrose Monohydrate 83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.13g, vitamin C 0.08g and folic acid
0.0006g is poured into three-dimensional mixer together；
2) the three-dimensional mixed dynamic mixing machine of starting is that 12r/min carries out mixed processing with the speed of mainshaft, incorporation time be 20min to get
Reagent.
Embodiment 3:
A kind of glucose reagent of screening for diabetes, the raw material including following parts by weight proportion: Dextrose Monohydrate 82.5g,
2- (4- methoxyphenoxy)-sodium propionate 0.12g, vitamin C 0.06g and folic acid 0.0004g.
A kind of preparation method of the glucose reagent of screening for diabetes, comprising the following steps:
1) 82.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.12g, vitamin C 0.06g and folic acid 0.0004g are fallen together
Enter into three-dimensional mixer；
2) the three-dimensional mixed dynamic mixing machine of starting is that 11r/min carries out mixed processing with the speed of mainshaft, incorporation time be 15min to get
Reagent.
Embodiment 4:
A kind of glucose reagent of screening for diabetes, the raw material including following parts by weight proportion: Dextrose Monohydrate 82.5g,
2- (4- methoxyphenoxy)-sodium propionate 0.12g, vitamin C 0.06g and folic acid 0.0004g.
The raw material also matched in the present embodiment containing following parts by weight: fumaric acid 0.002g and chitin 0.01
g
A kind of preparation method of the glucose reagent of screening for diabetes, comprising the following steps:
1) by 82.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.12g, vitamin C 0.06g, folic acid 0.0004g and anti-fourth
Enedioic acid 0.002g and 0.01 g of chitin are poured into three-dimensional mixer together；
2) the three-dimensional mixed dynamic mixing machine of starting is that 11r/min carries out mixed processing with the speed of mainshaft, incorporation time be 15min to get
Reagent.
Experimental example:
Experimental subjects: 120 triers.
Test method: control group is carried out using sugared screening reagent on the market, experimental group using reagent made from embodiment 3
Flavor laboratory, 120 triers try out reagent respectively, and reagent is dissolved in respectively in the pure water of 300ml when use, trier
It gargles after having tried out the first reagent.
The comparing result of 2 groups of user is as follows, as a result see the table below:
Checked that most people think that experimental group is more in good taste than control group, it is easier to entrance by experiment.
Nutrition measuration is carried out to reagent made from embodiment 3:
The beneficial effects of the present invention are: it is used as suppression edulcorant by the way that 2- (4- methoxyphenoxy)-sodium propionate is added, it can be effective
Improve mouthfeel, reagent is allowed to be easier entrance.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the protection scope of the present invention.
Claims (5)
1. a kind of glucose reagent of screening for diabetes, which is characterized in that the raw material including following parts by weight proportion a: water
Glucose 80.5-83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10-0.13 g, vitamin C 0.04-0.08g and leaf
Sour 0.0002-0.0006g.
2. a kind of glucose reagent of screening for diabetes as described in claim 1, which is characterized in that including following parts by weight
The raw material of number proportion: Dextrose Monohydrate 80.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10g, vitamin C 0.04g and leaf
Sour 0.0002g.
3. a kind of glucose reagent of screening for diabetes as described in claim 1, which is characterized in that including following parts by weight
The raw material of number proportion: Dextrose Monohydrate 83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.13g, vitamin C 0.08g and leaf
Sour 0.0006g.
4. a kind of glucose reagent of screening for diabetes as described in claim 1, which is characterized in that including following parts by weight
The raw material of number proportion: Dextrose Monohydrate 82.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.12g, vitamin C 0.06g and leaf
Sour 0.0004g.
5. a kind of preparation method of the glucose reagent of screening for diabetes, which comprises the following steps:
1) by Dextrose Monohydrate 80.5-83.5g, 2- (4- methoxyphenoxy)-sodium propionate 0.10-0.13 g, vitamin C
0.04-0.08g and folic acid 0.0002-0.0006g are poured into three-dimensional mixer together；
2) the three-dimensional mixed dynamic mixing machine of starting is that 10-12r/min carries out mixed processing, incorporation time 10- with the speed of mainshaft
20min is to get reagent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811614895.2A CN109550059A (en) | 2018-12-27 | 2018-12-27 | A kind of glucose reagent of screening for diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811614895.2A CN109550059A (en) | 2018-12-27 | 2018-12-27 | A kind of glucose reagent of screening for diabetes and preparation method thereof |
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| CN109550059A true CN109550059A (en) | 2019-04-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811614895.2A Pending CN109550059A (en) | 2018-12-27 | 2018-12-27 | A kind of glucose reagent of screening for diabetes and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648024A (en) * | 2009-09-02 | 2010-02-17 | 吴光彦 | Medicinal liquid preparation of glucose for OGTT and preparation method thereof |
| CN107412789A (en) * | 2017-09-18 | 2017-12-01 | 杨越安 | A kind of sugar sieve agent and preparation method thereof |
| CN108289963A (en) * | 2015-11-06 | 2018-07-17 | 营养Dna控股有限公司 | For testing the method responded for oral glucose load and product |
-
2018
- 2018-12-27 CN CN201811614895.2A patent/CN109550059A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648024A (en) * | 2009-09-02 | 2010-02-17 | 吴光彦 | Medicinal liquid preparation of glucose for OGTT and preparation method thereof |
| CN108289963A (en) * | 2015-11-06 | 2018-07-17 | 营养Dna控股有限公司 | For testing the method responded for oral glucose load and product |
| CN107412789A (en) * | 2017-09-18 | 2017-12-01 | 杨越安 | A kind of sugar sieve agent and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 翟静 等主编: "《生物化学》", 31 July 2016, 中国医药科技出版社 * |
| 郑建仙 编著: "《功能性食品甜味剂》", 30 November 1997, 中国轻工业出版社 * |
| 郝利平 等主编: "《食品添加剂》", 31 August 2002, 中国农业大学出版社 * |
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