CN109529114A - A kind of new material for manufacture of intraocular crystal - Google Patents
A kind of new material for manufacture of intraocular crystal Download PDFInfo
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- CN109529114A CN109529114A CN201910035564.1A CN201910035564A CN109529114A CN 109529114 A CN109529114 A CN 109529114A CN 201910035564 A CN201910035564 A CN 201910035564A CN 109529114 A CN109529114 A CN 109529114A
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- intraocular
- new material
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Abstract
The present invention provides a kind of new materials for manufacture of intraocular crystal, the technical solution is with polymethyl methacrylate main material, and preferred other altered contents, pass through addition polyethylene terephthalate, fatty alcohol polyoxyethylene ether and Sodium Hyaluronate, crosslinked action can be played to methyl methacrylate monomer, to reduce material hardness, and maintain certain tensile strength；On this basis, the present invention is using the non-toxic components such as diphenyl carbonate, dimethyl fumarate, styrene methylacrylate and PMMA mixture, the fusing point of composition can be improved to a certain extent, experiments verify that showing, it is solid that this material, which is heated to 120 DEG C still, formalness has no change, while maintaining the mechanical property under room temperature substantially；Room temperature is down to after heating, light transmittance remains unchanged.The present invention has carried out large-scale ingredient improvement to the raw material for preparing of artificial lens, and scheme is reasonable, and effect is prominent, great promotion potential.
Description
Technical field
The present invention relates to intraocular lens' technical fields, and in particular to a kind of new material for manufacture of intraocular crystal.
Background technique
Artificial lens is also known as intraocular lens, is the precision that itself the muddy crystal extractd is replaced in underwent operative implantation eyes
Optical component.The main ingredient of mankind's crystal is protein and moisture content, it can occur being atomized because of aging or the situation of muddiness,
And the crystal being atomized then can hinder light and image to project on retina.Eyes are impaired, certain disease, even some drugs
Treatment is likely to the phenomenon that causing crystal to be atomized；According to statistics, it is also necessary derived from the mankind for having more than 90% cataract case
Ageing process, be that the crystal of eyes becomes muddy, then eyesight is affected, and mechanism is still not clear, and drug therapy is so far not
It makes a breakthrough.The unique really effective treatment method of cataract is exactly operative treatment, i.e., having become opaque crystalline substance
Shape body is taken away, and changes an artificial crystal, here it is artificial lens.Intraocular lens implantation is that treatment cataract is most effective
Means, thousands of cataract patient obtain good eyesight by this safe and effective operation method.
Artificial lens is the changeless lens of a kind of diopter synthesized by artificial material, the material of manufacture of intraocular crystal
Should have following characteristics: (1) optical property is good, and infractive index is high, it is seen that light transmission rate is high (light transmittance is greater than 90%)；(2)
Light weight, stretching resistance are strong；(3) intraocular physicochemical property is stablized, and durability is strong, object biodegradation；(4) nontoxic, no cause is scorching, causes
It is carcinous；(5) no antigen；(6) easy to process.In the prior art, intraocular lens generally use polymethyl methacrylate
It (PMMA) is main material, PMMA in industrial product, and was used by people to manufacture of intraocular crystal since 1933 at first,
Show PMMA material with light, non-breakable, performance is stable, performance is stable, infractive index is high through clinical verification in more than 50 years
The advantages that, however, directly contacting in operation with corneal endothelium can lead to endothelial cell damage since its hardness is higher, and this
Class material thermal resistance is poor, and at 100 DEG C hereinafter, PMMA is solid-state, the environment more than 100 DEG C, PMMA will be become gel-like, thus
Not resistant against high temperatures, autoclave sterilization；Easily by YAG damage from laser, and the monomer with bio-toxicity can be discharged after laser therapy.
Recently as the development of the super breast conserving surgery of small notch Sutureless, the demand to foldable (soft) artificial lens is produced, hardness
The application of material PMMA is gradually restricted.
Summary of the invention
The present invention is directed to be directed to the technological deficiency of the prior art, a kind of new material for manufacture of intraocular crystal is provided,
To solve the higher technical problem of intraocular lens' hardness prepared by routine PMMA material in the prior art.
Another technical problem to be solved by the present invention is that intraocular lens' heat resistance prepared by routine PMMA material is poor.
To realize the above technical purpose, the invention adopts the following technical scheme:
A kind of new material for manufacture of intraocular crystal, the material include the ingredient of following parts by weight: polymethyl
78~85 parts of sour methyl esters, 11~17 parts of polyethylene terephthalate, 6~10 parts of styrene methylacrylate, dipheryl carbonate
5~9 parts of ester, 5~7 parts of dimethyl fumarate, 3~5 parts of ethyl-para-hydroxybenzoate, 2~3 parts of sodium perborate, boric acid three
2~3 parts of isopropyl ester, 1.5~1.8 parts of p-methyl benzenesulfonic acid, 1~1.2 part of choline chloride.
Preferably, the material further includes the fatty alcohol polyoxyethylene ether of 1~2 parts by weight.
Preferably, the material further includes the Sodium Hyaluronate of 1~2 parts by weight.
Preferably, the material further includes the polysulfone resin of 1~2 parts by weight.
Preferably, the material further includes the hydroxyethyl cellulose of 1~2 parts by weight.
Preferably, the material is composed of the following components in parts by weight: 81 parts of polymethyl methacrylate, poly- terephthaldehyde
14 parts of sour glycol ester, 8 parts of styrene methylacrylate, 7 parts of diphenyl carbonate, 6 parts of dimethyl fumarate, para hydroxybenzene
4 parts of Ethyl formate, 2.5 parts of sodium perborate, 2.5 parts of triisopropyl borate ester, 1.7 parts of p-methyl benzenesulfonic acid, 1.1 parts of choline chloride.
Preferably, the material is composed of the following components in parts by weight: 81 parts of polymethyl methacrylate, poly- terephthaldehyde
14 parts of sour glycol ester, 8 parts of styrene methylacrylate, 7 parts of diphenyl carbonate, 6 parts of dimethyl fumarate, para hydroxybenzene
4 parts of Ethyl formate, 2.5 parts of sodium perborate, 2.5 parts of triisopropyl borate ester, 1.7 parts of p-methyl benzenesulfonic acid, 1.1 parts of choline chloride, rouge
1.5 parts of fat alcohol polyoxyethylene ether, 1.5 parts of Sodium Hyaluronate, 1.5 parts of polysulfone resin, 1.5 parts of hydroxyethyl cellulose.
The present invention provides a kind of new materials for manufacture of intraocular crystal, and the technical solution is with poly-methyl methacrylate
Ester main material, and other preferred altered contents pass through addition polyethylene terephthalate, fatty alcohol polyoxyethylene ether
And Sodium Hyaluronate, crosslinked action can be played to methyl methacrylate monomer, to reduce material hardness, and maintain one
Fixed tensile strength；On this basis, the present invention uses diphenyl carbonate, dimethyl fumarate, styrene acrylic first
The non-toxic components such as ester and PMMA mixture, can improve to a certain extent the fusing point of composition, experiments verify that showing this material
Being heated to 120 DEG C still is solid, and formalness has no change, while maintaining the mechanical property under room temperature substantially；It is dropped after heating
To room temperature, light transmittance is remained unchanged.The present invention has carried out large-scale ingredient improvement, scheme to the raw material for preparing of artificial lens
Rationally, effect is prominent, great promotion potential.
Specific embodiment
Below by specific embodiments of the present invention will be described in detail.In order to avoid excessive unnecessary details,
It will not be described in detail in following embodiment to belonging to well known structure or function.Approximation used in following embodiment
Language can be used for quantitative expression, show to allow quantity to have certain variation in the case where not changing basic function.It is fixed except having
Adopted outer, technical and scientific term used in following embodiment has the phase being commonly understood by with those skilled in the art of the invention
Same meaning.
Embodiment 1
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
81 parts of e pioic acid methyl ester, 14 parts of polyethylene terephthalate, 8 parts of styrene methylacrylate, 7 parts of diphenyl carbonate, anti-fourth
6 parts of enedioic acid dimethyl ester, 4 parts of ethyl-para-hydroxybenzoate, 2.5 parts of sodium perborate, 2.5 parts of triisopropyl borate ester, to toluene sulphur
1.7 parts, 1.1 parts of choline chloride of acid.
Embodiment 2
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
81 parts of e pioic acid methyl ester, 14 parts of polyethylene terephthalate, 8 parts of styrene methylacrylate, 7 parts of diphenyl carbonate, anti-fourth
6 parts of enedioic acid dimethyl ester, 4 parts of ethyl-para-hydroxybenzoate, 2.5 parts of sodium perborate, 2.5 parts of triisopropyl borate ester, to toluene sulphur
1.7 parts of acid, 1.1 parts of choline chloride, 1.5 parts of fatty alcohol polyoxyethylene ether, 1.5 parts of Sodium Hyaluronate, 1.5 parts of polysulfone resin, hydroxyl
1.5 parts of ethyl cellulose.
Embodiment 3
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
78 parts of e pioic acid methyl ester, 11 parts of polyethylene terephthalate, 6 parts of styrene methylacrylate, 5 parts of diphenyl carbonate, anti-fourth
5 parts of enedioic acid dimethyl ester, 3 parts of ethyl-para-hydroxybenzoate, 2 parts of sodium perborate, 2 parts of triisopropyl borate ester, p-methyl benzenesulfonic acid 1.5
Part, 1 part of choline chloride.
Embodiment 4
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
85 parts of e pioic acid methyl ester, 17 parts of polyethylene terephthalate, 10 parts of styrene methylacrylate, 9 parts of diphenyl carbonate, anti-fourth
7 parts of enedioic acid dimethyl ester, 5 parts of ethyl-para-hydroxybenzoate, 3 parts of sodium perborate, 3 parts of triisopropyl borate ester, p-methyl benzenesulfonic acid 1.8
Part, 1.2 parts of choline chloride.
Embodiment 5
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
81 parts of e pioic acid methyl ester, 14 parts of polyethylene terephthalate, 8 parts of styrene methylacrylate, 7 parts of diphenyl carbonate, anti-fourth
6 parts of enedioic acid dimethyl ester, 4 parts of ethyl-para-hydroxybenzoate, 2.5 parts of sodium perborate, 2.5 parts of triisopropyl borate ester, to toluene sulphur
1.7 parts, 1.1 parts of choline chloride, 1 part of fatty alcohol polyoxyethylene ether, 1 part of Sodium Hyaluronate, 1 part of polysulfone resin of acid.
Embodiment 6
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
79 parts of e pioic acid methyl ester, 12 parts of polyethylene terephthalate, 7 parts of styrene methylacrylate, 6 parts of diphenyl carbonate, anti-fourth
5.5 parts of enedioic acid dimethyl ester, 3.5 parts of ethyl-para-hydroxybenzoate, 2.2 parts of sodium perborate, 2.4 parts of triisopropyl borate ester, to first
1.6 parts of benzene sulfonic acid, 1 part of choline chloride, 1 part of hydroxyethyl cellulose.
Embodiment 7
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
83 parts of e pioic acid methyl ester, 16 parts of polyethylene terephthalate, 9 parts of styrene methylacrylate, 8 parts of diphenyl carbonate, anti-fourth
6.5 parts of enedioic acid dimethyl ester, 4.5 parts of ethyl-para-hydroxybenzoate, 2.9 parts of sodium perborate, 2.8 parts of triisopropyl borate ester, to first
1.7 parts of benzene sulfonic acid, 1.2 parts of choline chloride, 2 parts of fatty alcohol polyoxyethylene ether, 2 parts of Sodium Hyaluronate.
Embodiment 8
A kind of new material for manufacture of intraocular crystal, the material are composed of the following components in parts by weight: poly- methyl-prop
85 parts of e pioic acid methyl ester, 11 parts of polyethylene terephthalate, 10 parts of styrene methylacrylate, 5 parts of diphenyl carbonate, anti-fourth
7 parts of enedioic acid dimethyl ester, 3 parts of ethyl-para-hydroxybenzoate, 3 parts of sodium perborate, 2 parts of triisopropyl borate ester, p-methyl benzenesulfonic acid 1.8
Part, 1 part of choline chloride, 2 parts of polysulfone resin, 2 parts of hydroxyethyl cellulose.
The embodiments of the present invention have been described in detail above, but content is only the preferred embodiment of the present invention,
It is not intended to limit the invention.All any modifications, equivalent replacements, and improvements etc. done in application range of the invention, should all
It is included within protection scope of the present invention.
Claims (7)
1. a kind of new material for manufacture of intraocular crystal, it is characterised in that the material includes the ingredient of following parts by weight: poly-
78~85 parts of methyl methacrylate, 11~17 parts of polyethylene terephthalate, 6~10 parts of styrene methylacrylate,
5~9 parts of diphenyl carbonate, 5~7 parts of dimethyl fumarate, 3~5 parts of ethyl-para-hydroxybenzoate, sodium perborate 2~3
Part, 2~3 parts of triisopropyl borate ester, 1.5~1.8 parts of p-methyl benzenesulfonic acid, 1~1.2 part of choline chloride.
2. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material also wraps
Include the fatty alcohol polyoxyethylene ether of 1~2 parts by weight.
3. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material also wraps
Include the Sodium Hyaluronate of 1~2 parts by weight.
4. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material also wraps
Include the polysulfone resin of 1~2 parts by weight.
5. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material also wraps
Include the hydroxyethyl cellulose of 1~2 parts by weight.
6. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material by with
Lower parts by weight at being grouped as: 81 parts of polymethyl methacrylate, 14 parts of polyethylene terephthalate, styrene acrylic
8 parts of methyl esters, 7 parts of diphenyl carbonate, 6 parts of dimethyl fumarate, 4 parts of ethyl-para-hydroxybenzoate, 2.5 parts of sodium perborate,
2.5 parts of triisopropyl borate ester, 1.7 parts of p-methyl benzenesulfonic acid, 1.1 parts of choline chloride.
7. a kind of new material for manufacture of intraocular crystal according to claim 1, it is characterised in that the material by with
Lower parts by weight at being grouped as: 81 parts of polymethyl methacrylate, 14 parts of polyethylene terephthalate, styrene acrylic
8 parts of methyl esters, 7 parts of diphenyl carbonate, 6 parts of dimethyl fumarate, 4 parts of ethyl-para-hydroxybenzoate, 2.5 parts of sodium perborate,
2.5 parts of triisopropyl borate ester, 1.7 parts of p-methyl benzenesulfonic acid, 1.1 parts of choline chloride, 1.5 parts of fatty alcohol polyoxyethylene ether, hyalomitome
1.5 parts of sour sodium, 1.5 parts of polysulfone resin, 1.5 parts of hydroxyethyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910035564.1A CN109529114A (en) | 2019-01-15 | 2019-01-15 | A kind of new material for manufacture of intraocular crystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910035564.1A CN109529114A (en) | 2019-01-15 | 2019-01-15 | A kind of new material for manufacture of intraocular crystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109529114A true CN109529114A (en) | 2019-03-29 |
Family
ID=65835508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910035564.1A Pending CN109529114A (en) | 2019-01-15 | 2019-01-15 | A kind of new material for manufacture of intraocular crystal |
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| CN (1) | CN109529114A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743255A (en) * | 1986-10-20 | 1988-05-10 | Bardenstein David S | Radiopaque intra-ocular lens implant |
| CN1052256A (en) * | 1989-12-05 | 1991-06-19 | 苏联科学院化学物理研究所 | Artificial lenses and polymer composition for making thereof |
| CN1255079A (en) * | 1997-05-08 | 2000-05-31 | 博士伦外科公司 | Intraocular lens tumbling process using coated beads |
| CN1799522A (en) * | 2005-11-17 | 2006-07-12 | 陈晓勇 | Method for preparing filmy intraocular lens |
| CN106362215A (en) * | 2015-07-23 | 2017-02-01 | 爱博诺德（北京）医疗科技有限公司 | Intraocular lens for preventing and treating after cataract, and preparation method thereof |
| CN106362205A (en) * | 2016-08-29 | 2017-02-01 | 温州医科大学 | Zwitterionic surface-modified artificial lens and preparation method thereof |
-
2019
- 2019-01-15 CN CN201910035564.1A patent/CN109529114A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743255A (en) * | 1986-10-20 | 1988-05-10 | Bardenstein David S | Radiopaque intra-ocular lens implant |
| CN1052256A (en) * | 1989-12-05 | 1991-06-19 | 苏联科学院化学物理研究所 | Artificial lenses and polymer composition for making thereof |
| CN1255079A (en) * | 1997-05-08 | 2000-05-31 | 博士伦外科公司 | Intraocular lens tumbling process using coated beads |
| CN1799522A (en) * | 2005-11-17 | 2006-07-12 | 陈晓勇 | Method for preparing filmy intraocular lens |
| CN106362215A (en) * | 2015-07-23 | 2017-02-01 | 爱博诺德（北京）医疗科技有限公司 | Intraocular lens for preventing and treating after cataract, and preparation method thereof |
| CN106362205A (en) * | 2016-08-29 | 2017-02-01 | 温州医科大学 | Zwitterionic surface-modified artificial lens and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谢立信主编: "《人工晶体植入学 第2版》", 30 April 1994, 人民卫生出版社 * |
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Application publication date: 20190329 |