CN109529094A - A kind of efficient hemostatic material and preparation method thereof can promote wound healing - Google Patents
A kind of efficient hemostatic material and preparation method thereof can promote wound healing Download PDFInfo
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- CN109529094A CN109529094A CN201811309486.1A CN201811309486A CN109529094A CN 109529094 A CN109529094 A CN 109529094A CN 201811309486 A CN201811309486 A CN 201811309486A CN 109529094 A CN109529094 A CN 109529094A
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- preparation
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- chitosan
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- wound healing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a kind of efficient hemostatic materials and preparation method thereof that can promote wound healing.This method is by spherical porous CaCO3Compound rear freeze-drying is mixed in powder dispersion liquid and chitosan solution, and grind into powder can promote the efficient hemostatic material of wound healing to obtain the final product.The present invention is with porous C aCO3For substrate, by with chitosan it is compound after pulverize, realize excellent anthemorrhagic performance and the facilitation to wound healing.The material realizes higher blood coagulation efficiency, by reduced clotting time to 16s.Appropriate powder is uniformly sprinkling upon mouse by timing to be allowanced for bark on the wound of 1cm*1cm, wound can heal within 9 days, substantially reduce wound healing time.What the present invention was prepared can promote the efficient hemostatic material of wound healing with good biocompatibility, nontoxicity, and ideal low hemolytic energy.
Description
Technical field
The invention belongs to technical field of preparation for inorganic material, in particular to a kind of efficient hemostatic material that can promote wound healing
Material and preparation method thereof.The present invention is with porous C aCO3For substrate, by with chitosan it is compound after pulverize to obtain and can promote wound
The efficient hemostatic material of mouth healing.
Background technique
The main reason for uncontrollable big bleeding is war, traffic accident and other accident deaths.It develops in the short time
The emergency survival hemostatic material of hemostasis, can be effectively reduced death caused by bleeding.Therefore research and development haemostatic effect is good, secondary work
It is a problem in the urgent need to address with low hemostatic material.
Inorganic hemostatic materials have long-term physics and chemical stability, play the role of accelerating hemostasis and promote surface of a wound group
The effect of regeneration, reparation, healing is knitted, while also because it can be anti-to avoid the allergy as caused by animal derived or humanized's albumen
It answers, so the hemostat based on these inorganic raw materials has very high practicability.At present by all trades and professions extensive concern, curing
The application study of the numerous areas such as medicine, food, chemical industry, biochemistry and biomedical engineering achieves major progress.
Although existing inorganic hemostatic materials have been provided with as good anthemorrhagic performance, but do not have also enough efficiently
Hemostasis efficiency and biocompatible characteristic.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a kind of efficient hemostatic materials that can promote wound healing
Material and preparation method thereof.This method passes through synthesis porous C aCO3, then obtain to promote by freeze-drying after mechanical mixture with chitosan
Into the efficient hemostatic material of wound healing.
The efficient hemostatic material of the present invention that can promote wound healing the preparation method comprises the following steps: by spherical porous CaCO3
Compound rear freeze-drying is mixed in powder dispersion liquid and chitosan solution, and grind into powder can promote the height of wound healing to obtain the final product
Imitate hemostatic material.
The mass concentration of the chitosan solution is 1%-2%.
The spherical porous CaCO3The preparation method comprises the following steps: under conditions of room temperature is vigorously stirred, by 0.05-0.50M's
Na2CO3Solution is quickly poured into 0.05-0.50M CaCl2In solution, filtered after the precipitating of generation is washed with distilled water, in air
It is dry in room temperature.
The preparation method of the chitosan solution: weighing 3-8g chitosan in 1L flask, and 250-500mL distillation is added
The 1-2wt%CH now matched is at the uniform velocity added dropwise under conditions of magnetic agitation in water3COOH solution 5g, it is abundant to continue stirring until chitosan
Dissolution, solution are in clear.
By spherical porous CaCO3Compound concrete operations are mixed in powder dispersion liquid and chitosan solution are as follows: in magnetic force
Under the action of stirring, by the spherical porous CaCO of 6-15g3Powder is scattered in 200mL distilled water, is subsequently poured into 100-300mL shell
In glycan solution, continues stirring until powder and be well-dispersed in solution.
The CaCO3Selected from one or more of calcite, aragonite or vaterite.
By the spherical porous CaCO3Powder is substituted for dolomite, montmorillonite, kaolin, marmor serpentinatum, raddle or zeolite
At least one of powder.
The present invention passes through the different natural inorganic mineral hemostatic material of selection and the polysaccharide material with biocompatibility, with
Different combinations is lyophilized after carrying out mechanical mixture, to obtain can promote the efficient hemostatic material of wound healing.Chitosan can be with
The biocompatibility and degradability for increasing material, with CaCO3Mechanical mixture is carried out with certain proportion range, to neither influence
The acquired efficient hemostatic material with biocompatibility it is compound, and will not substantially change the size of material.
Compared with prior art, porous C aCO of the present invention3For substrate, by be lyophilized after chitosan mechanical mixture it is compound,
Realize the biocompatibility of inorganic mineral hemostatic material.This can promote the characteristics of efficient hemostatic material of wound healing be realize
Higher blood coagulation efficiency, by reduced clotting time to 16s.Appropriate powder is uniformly sprinkling upon mouse by timing and is allowanced for bark 1cm*
On the wound of 1cm, wound can heal within 9 days, substantially reduce wound healing time.Preparation method of the invention is easy,
General, the efficient hemostatic material that can promote wound healing being prepared has good water solubility, and non-toxic, hemostasis efficiency is high
And can promote the performance of wound healing, it can be applied to field of biological pharmacy.
Detailed description of the invention
Fig. 1 is the operation schematic diagram of the efficient hemostatic material that can promote wound healing of the invention.
Fig. 2 is the porous C aCO synthesized in embodiment 13The scanning electron microscope (SEM) photograph of material.
Fig. 3 is inorganic hemostatic materials and its XRD diagram with the composite material of chitosan in embodiment 1.
Fig. 4 is inorganic hemostatic materials and its infrared figure with the composite material of chitosan in embodiment 1.
Fig. 5 is the potential profile of hemostatic material compound with chitosan in embodiment 1.
Fig. 6 is the grain size distribution of hemostatic material compound with chitosan in embodiment 1.
Fig. 7 is inorganic hemostatic materials and its external blood coagulation figure with the composite material of chitosan in embodiment 1.
Fig. 8 is inorganic hemostatic materials and its hemolysis figure with the composite material of chitosan in embodiment 1.
Fig. 9 is inorganic hemostatic materials and its animal wound recovery figure with the composite material of chitosan in embodiment 1.
Figure 10 is the external blood coagulation erythrocyte aggregation scanning electron microscope (SEM) photograph of hemostatic material compound with chitosan in embodiment 1.
Figure 11 is inorganic hemostatic materials and its cytotoxicity figure with the composite material of chitosan in embodiment 1.
Specific embodiment
To make those skilled in the art more fully understand technical solution of the present invention, below with reference to embodiment to the present invention
A kind of efficient hemostatic material and preparation method thereof that can promote wound healing of offer is described in detail.
Experimental method used in following embodiments is conventional method unless otherwise specified；Institute in following embodiments
Reagent, material etc., are commercially available unless otherwise specified.
Embodiment 1:
(1) spherical porous CaCO3The preparation of powder: 16.6g CaCl is successively weighed2、15.6g Na2CO3, sufficiently molten respectively
Solution is in 300mL distilled water.Under conditions of room temperature is vigorously stirred, by Na2CO3Solution (0.1M) is quickly poured into CaCl2(0.1M)
In solution.It is filtered after the precipitating of generation is washed with distilled water 3 times, it is dry in air chamber middle benefit gas.
The dissolution of (2) 1% chitosans: weighing 5g chitosan in 1L flask, 500mL distilled water is added, in magnetic agitation
Under conditions of, the 1wt%CH now matched is at the uniform velocity added dropwise3COOH solution 5g.12h is persistently stirred, until chitosan sufficiently dissolves, solution is in
Clear.
(3)CaCO3It is compound with chitosan: under the action of magnetic agitation, CaCO prepared by 10g step (1)3Powder
It is scattered in 200mL distilled water, is subsequently poured into 200mL chitosan solution, continue stirring until powder and be well-dispersed in solution
After freeze.
(4) processing of composite material: freeze-drying is ground into fine powder.
(5) by fibroblast cytotoxicity assay obtain the material within the scope of institute's test concentrations to cell without
Toxicity.
Embodiment 2:
(1) spherical porous CaCO3Preparation: successively weigh 11.0g CaCl2、10.5g Na2CO3, it is completely dissolved in respectively
In 300mL distilled water.Under conditions of room temperature is vigorously stirred, by Na2CO3Solution (0.33M) is quickly poured into CaCl2(0.33M) is molten
In liquid.It is filtered after the precipitating of generation is washed with distilled water 3 times, it is dry in air chamber middle benefit gas.
The dissolution of (2) 1% chitosans: weighing 5g chitosan in 1L flask, 500mL distilled water is added, in magnetic agitation
Under conditions of, the 1%CH now matched is at the uniform velocity added dropwise3COOH solution 5g.12h is persistently stirred, until chitosan sufficiently dissolves, solution is in clear
It is clear bright.
(3)CaCO3It is compound with chitosan: under the action of magnetic agitation, by 10g CaCO3Powder de-agglomeration is steamed in 200mL
After in distilled water, pour into 200mL chitosan solution.Continue stirring until freezing after powder is well-dispersed in solution.
(4) processing of composite material: freeze-drying is ground into fine powder.
(5) by fibroblast cytotoxicity assay obtain the material within the scope of institute's test concentrations to cell without
Toxicity.
It is higher solidifying that the test for the efficient hemostatic material that can promote wound healing obtained by above-mentioned shows that the material realizes
Blood efficiency, by reduced clotting time to 16s.Appropriate powder is uniformly sprinkling upon the wound that mouse is allowanced for bark 1cm*1cm by timing
On, wound can heal within 9 days, substantially reduce wound healing time.What the present invention was prepared can promote wound healing
Efficient hemostatic material there is good biocompatibility, it is non-toxic, and ideal low hemolytic energy.
Example of the invention is explained in detail above in conjunction with embodiment, but the present invention is not limited to examples detailed above,
All any improvement and modification made for the present invention belong to the protection scope of the claims in the present invention.
Claims (7)
1. a kind of preparation method for the efficient hemostatic material that can promote wound healing, which is characterized in that this method is that spherical shape is more
Hole CaCO3Compound rear freeze-drying is mixed in powder dispersion liquid and chitosan solution, and grind into powder can promote wound to obtain the final product
The efficient hemostatic material of healing.
2. preparation method according to claim 1, which is characterized in that the mass concentration of the chitosan solution is 1%-
2%.
3. preparation method according to claim 1 or 2, which is characterized in that the spherical porous CaCO3The preparation method comprises the following steps:
Under conditions of room temperature is vigorously stirred, by the Na of 0.05-0.50M2CO3Solution is quickly poured into 0.05-0.50M CaCl2In solution,
It is filtered after the precipitating of generation is washed with distilled water, it is dry in air chamber middle benefit gas.
4. preparation method according to claim 3, which is characterized in that the preparation method of the chitosan solution: weigh 3-
8g chitosan is added 250-500mL distilled water and the 1- now matched is at the uniform velocity added dropwise under conditions of magnetic agitation in 1L flask
2wt%CH3COOH solution 5g, continues stirring until chitosan and sufficiently dissolves, and solution is in clear.
5. the preparation method according to claim 4, which is characterized in that by spherical porous CaCO3Powder dispersion liquid and chitosan
Compound concrete operations are mixed in solution are as follows: under the action of magnetic agitation, by the spherical porous CaCO of 6-15g3Powder dispersion
It in 200mL distilled water, is subsequently poured into 100-300mL chitosan solution, continues stirring until powder and be well-dispersed in solution.
6. preparation method according to claim 1 or 2, which is characterized in that the CaCO3Selected from calcite, aragonite or ball rosy clouds
One or more of stone.
7. preparation method according to claim 1 or 2, which is characterized in that by the spherical porous CaCO3Powder is substituted for
The powder of at least one of dolomite, montmorillonite, kaolin, marmor serpentinatum, raddle or zeolite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811309486.1A CN109529094A (en) | 2018-11-05 | 2018-11-05 | A kind of efficient hemostatic material and preparation method thereof can promote wound healing |
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| CN201811309486.1A CN109529094A (en) | 2018-11-05 | 2018-11-05 | A kind of efficient hemostatic material and preparation method thereof can promote wound healing |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113230447A (en) * | 2021-05-24 | 2021-08-10 | 河北工业大学 | Hemostatic repair material and preparation method thereof |
| CN114748676A (en) * | 2022-04-08 | 2022-07-15 | 四川大学 | Chitosan-based efficient hemostatic with Janus structure, and preparation method and application thereof |
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Cited By (4)
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Application publication date: 20190329 |