CN109528911A - A kind of Silica hydrogel scar plaster and preparation method - Google Patents

A kind of Silica hydrogel scar plaster and preparation method Download PDF

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Publication number
CN109528911A
CN109528911A CN201910030004.7A CN201910030004A CN109528911A CN 109528911 A CN109528911 A CN 109528911A CN 201910030004 A CN201910030004 A CN 201910030004A CN 109528911 A CN109528911 A CN 109528911A
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silica hydrogel
scar
parts
plaster
chinese medicine
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王斌
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

The invention belongs to medicine technology field, a kind of Silica hydrogel scar plaster and preparation method are disclosed；It is made of medical polyurethane and silica gel；Silica gel is coated with by medical polyurethane to be made；The present invention is widely used in the reparation of the postoperative hyperplastic scar of the surgical departments such as gynemetrics, Department of B urn, plastic surgery, department of general surgery, and the treatment for keloid.The Silica hydrogel of use not send out by adhesive hair, and comfortable tenderness is pasted in noresidue；It can paste repeatedly, it is capable of washing；Wound mucous membrane new life epithelium and surrounding skin, no pain are not damaged when removing；It is light, easy to use, quality is more soft, compliance is good, corporal parts can be suitble to；With good buffering effect and heat-proof quality, patient is made to feel more comfortable；It can treat healed hyperplastic scar and keloid；Hyperplastic scar and keloid are covered, can be made by burning, wound, scar area caused by operation is operated on reduces, and color is moved back shallowly；Pigment shoals, and mitigates itch pain.

Description

A kind of Silica hydrogel scar plaster and preparation method
Technical field
The invention belongs to medicine technology field more particularly to a kind of Silica hydrogel scar plaster and preparation methods.
Background technique
Currently, the prior art commonly used in the trade is such that
Even if since operation, traffic accident, incised wound and burn have been healed, but also can scar, hyperplastic scar and scar Trace pimple seriously affects image in naked leak, and the serious limb function that will lead to declines, and even results in canceration；Furthermore have A kind of crowd, belongs to scar constitution, slight scratch also can scar and desalination speed it is slow, brought seriously to this kind of crowd Puzzlement, therefore it is all kinds of given birth to except scar products application, including the scar frost, scar of dispelling cream of dispelling, spray, but scar of dispelling is ineffective, It cannot use at any time；Scar of dispelling patch, hair easy to stick, residual are unable to Reusability, wound mucous membrane new life epithelium are easy to damage when removing And surrounding skin, there is pain；In addition there are dispelling scar by beauty treatment, drug therapy and laser to improve scar, there is risk Property and costly, brings new psychological burden.
In conclusion problem of the existing technology is:
In the prior art, scar of dispelling product is generally dispel scar frost, scar of dispelling cream, spray, but scar of dispelling is ineffective, cannot be at any time It uses；Scar of dispelling patch, hair easy to stick, residual are unable to Reusability, wound mucous membrane new life epithelium and surrounding skin are easy to damage when removing Skin has pain；In addition there are dispelling scar by beauty treatment, drug therapy and laser to improve scar, there is risk and expense It is higher, bring new psychological burden.
Solve the difficulty and meaning of above-mentioned technical problem:
After scar is human skin tissue by extraneous various wounds, the skin fiber connective group in place of wound healing Hyperplasia filling is knitted, connection, supported, protected normal surrounding tissue and formed.If the cell of hyperplasia and the connective group of fibrosis It knits and is removed with a kind of safe method, then so that the surface of a wound is not re-formed connective tissue in agglutination by method appropriate and increase It is raw, prevent it that fibrosis occurs, then also just can not form scar.Therefore, present invention discover that the technology of general therapeutic scar point It dissipates, therapeutic effect table is shallow.Scar traditional Chinese medicine fine powder end now is controlled in the mixing of environmentally friendly grade Silica hydrogel to be cured in Elastic bandage (dressing), in this way Controlling scar Chinese medicinal ingredients will be precipitated from silica gel reticular structure together with silicone oil, and scar proliferation cell-wall breaking ratio is promoted to reach 90% More than；Effective component is also easy to extract, and is easy directly to be absorbed, and goes scar proliferation cell and fibrosis connective tissue safely Fall；It is pressurizeed simultaneously by Elastic bandage appropriate (dressing), the surface of a wound is made not re-form connective tissue proliferation in agglutination, hindered Only fibrosis occurs in it, then also just can not form scar.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of Silica hydrogel scar plaster and preparation method,
The invention is realized in this way a kind of Silica hydrogel scar plaster by medical polyurethane 30%, silica gel 30% and Chinese medicine at It is grouped as.
Further, traditional Chinese medicine ingredients are according to mass fraction by 10~50 parts of motherwort, 10~50 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 10~50 Part, 8~25 parts of Radix Angelicae Sinensis, 6~20 parts of safflower, 6~20 parts of aloe compositions.
Another object of the present invention is to provide a kind of preparation methods of Silica hydrogel scar plaster, specifically includes the following steps:
Step 1: take 10~50 parts of motherwort, 10~50 parts of Radix Salviae Miltiorrhizae, 10~50 parts of Rhizoma Chuanxiong, 8~25 parts of Radix Angelicae Sinensis, safflower 6~ 20 parts, 6~20 parts of aloe；Mixing is pulverized, and obtains medium particle diameter in 10~15 μm of Chinese medicine crushed materials below；
Step 2: according to the mass fraction, first by environmentally friendly 100~500 parts of grade Silica hydrogel component A, added with the environmental protection of curing agent 100~500 parts of B component of Silica hydrogel of grade is uniform in respective container for stirring respectively；Thereafter by environmentally friendly grade Silica hydrogel component A and B group Part mixes with 20~100 parts of Chinese medicine crushed material to stir evenly, and obtains the mixture of Silica hydrogel and Chinese medicine crushed material；
Step 3: being put into deaeration 5min in the vacuum tank of 0.08MPa for the mixture of Silica hydrogel and Chinese medicine crushed material, obtains The Silica hydrogel Chinese medicine matrix for treating scar；
Silica hydrogel Chinese medicine matrix: being coated in the cotton yarn surface layer of Elastic bandage by step 4 with coating machine, and coating silicon is solidifying The layer of glue Chinese medicine matrix is putting normal temperature laboratory solidification thereafter only, is obtaining Silica hydrogel Combined with Chinese Herbal prescription and control scar with a thickness of 2 millimeters Dressing.
Further, in step 1, polyurethane is medical polyurethane.
Further, in step 2, in the environmentally friendly grade Silica hydrogel B component added with curing agent, curing agent, environmentally friendly grade silicon The mass ratio of gel is 1:1.
Further, in step 4, the Elastic bandage is by elastic force non-woven fabrics, natural emulsion coating and cotton yarn surface layer structure At.
Another object of the present invention is to provide a kind of application method of Silica hydrogel scar plaster, specifically:
(1) scar plaster should use at least 12 hours daily, use within best 24 hours, persistently use 2~4 months；
(2) to avoid skin allergy, gradual plaster application method can be used, adapts to skin gradually；
(3) every can be Reusability 14~28 days, when scar plaster become difficult to clean or paste when, just need to change another New scar plaster.
Further, gradual plaster application method is initial two days application 4 hours daily, is applied 8 hours daily within two days later, Thereafter it is incremented by 2 hours daily, until can be applied with whole day 24 hours.
In conclusion advantages of the present invention and good effect are as follows:
Silica hydrogel scar plaster provided by the invention is widely used in the operation such as gynemetrics, Department of B urn, plastic surgery, department of general surgery The reparation of the postoperative hyperplastic scar of department, and the treatment for keloid.
The Silica hydrogel that the present invention uses not send out by adhesive hair, and comfortable tenderness is pasted in noresidue；It can paste repeatedly, it is capable of washing；It removes When do not damage wound mucous membrane new life epithelium and surrounding skin, no pain；The present invention is light, easy to use, quality is more soft, complies with Property is good, can be suitble to corporal parts；With good buffering effect and heat-proof quality, patient is made to feel more comfortable；It can treat Healed hyperplastic scar and keloid；Hyperplastic scar and keloid are covered, can be made by burning, wound, operation is operated on Caused scar area reduces, and color is moved back shallowly；It is only used for complete skin.Scar of dispelling effect is good, and devoid of risk, expense are low, alleviates and suffers from Person's pressure.Since the moisture-vapor transmission of scar plaster is not as good as the half of normal skin, the storage for making cuticula have water stayed, and skin absorbs After moisture, it is suppressed that the regeneration of capillary, to reduce the deposition of collagen；Meanwhile keratoderma water content increases Adding can be such that water soluble protein and product Penetration ration in cutin increases, and be spread rapidly, and scar is promoted to soften fading, and pigment becomes Shallowly, mitigate itch pain.
The silicone oil slowly released in pellosil can inhibit the increase of fibrocyte in cicatricial tissue, to inhibit to increase The formation of raw scar.
Effective ingredient in Silica hydrogel Combined with Chinese Herbal prescription of the present invention has to the softening of skin surface various scars, inhibits to increase It gives birth to, flatten, is antipruritic, decolourization；Primary efficacy is clearing and activating the channels and collaterals, activate blood circulation and disperse blood clots, resolving hard lump, antipruritic analgesic, saprophytic removing, The function of making extravasated blood dissipate can cure mainly the scar that various wounds are formed.
Scar Chinese medicine powder particle diameter is controlled at 10~15 μm hereinafter, scar cell-wall breaking ratio is made to reach 90% or more, effective component It is easy to extract and is also easy directly to be absorbed, promotes scar proliferation cell and fibrosis connective tissue to eliminate safely, reach radical cure Scar purpose.
It Elastic bandage (dressing), environmentally friendly Silica hydrogel and controls scar traditional Chinese medicine fine powder end three and merges one treatment scar.When silicon is solidifying Glue and Chinese prescription fine powder are mixed in silica gel, and treatment scar Chinese medicinal ingredients will be with silicone oil together from silica gel reticular structure It is precipitated, scar proliferation cell-wall breaking ratio is promoted to reach 90% or more；Effective component, which is easy to extract, to be also easy directly to be absorbed, and makes scar Trace proliferative cell and fibrosis connective tissue remove safely；It is pressurizeed simultaneously by Elastic bandage appropriate (dressing), the surface of a wound is made to exist Connective tissue proliferation is not re-formed in agglutination, prevent its occur fibrosis, inhibitions scar proliferation cell multi-faceted in this way with Fibrosis connective tissue, then also just can not form scar.
The Elastic bandage of Silica hydrogel Combined with Chinese Herbal prescription therapeutic scar can from outside to inside, promote scar cell and fibrosis knot Form tissue differentiation.And external application Silica hydrogel Chinese medicine controls scar dressing good biocompatibility, not will lead to patient and sticks position allergy, and it can To take off patch repeatedly, be conducive to local observation, safety and sanitation in this way, and beautiful and generous, be suitable for clinical and family and push away on a large scale Extensively.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of Silica hydrogel scar plaster provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Silica hydrogel scar plaster provided in an embodiment of the present invention is by by medical polyurethane 30%, silica gel 30% and traditional Chinese medicine ingredients group At.
Traditional Chinese medicine ingredients provided in an embodiment of the present invention according to mass fraction by 10~50 parts of motherwort, 10~50 parts of Radix Salviae Miltiorrhizae, 10~50 parts of Rhizoma Chuanxiong, 8~25 parts of Radix Angelicae Sinensis, 6~20 parts of safflower, 6~20 parts of aloe compositions.
Application principle of the invention is further elaborated with reference to the accompanying drawing；
As shown in Figure 1, the preparation method of Silica hydrogel scar plaster provided in an embodiment of the present invention, specifically includes the following steps:
S101: 10~50 parts of motherwort, 10~50 parts of Radix Salviae Miltiorrhizae, 10~50 parts of Rhizoma Chuanxiong, 8~25 parts of Radix Angelicae Sinensis, safflower 6~20 are taken Part, 6~20 parts of aloe；Mixing is pulverized, and obtains medium particle diameter in 10~15 μm of Chinese medicine crushed materials below；
S102: according to the mass fraction, first by environmentally friendly 100~500 parts of grade Silica hydrogel component A, added with the environmentally friendly grade of curing agent 100~500 parts of Silica hydrogel B component uniform in respective container for stirring respectively；Thereafter by environmentally friendly grade Silica hydrogel component A and B component It mixes and stirs evenly with 20~100 parts of Chinese medicine crushed material, obtain the mixture of Silica hydrogel and Chinese medicine crushed material；
S103: the mixture of Silica hydrogel and Chinese medicine crushed material is put into deaeration 5min in the vacuum tank of 0.08MPa, is controlled Treat the Silica hydrogel Chinese medicine matrix of scar；
Silica hydrogel Chinese medicine matrix: being coated in the cotton yarn surface layer of Elastic bandage by S104 with coating machine, is coated with Silica hydrogel The layer of Chinese medicine matrix with a thickness of 2 millimeters, thereafter only putting normal temperature laboratory solidification, obtain Silica hydrogel Combined with Chinese Herbal prescription control scar apply Material.
In step S101, polyurethane provided in an embodiment of the present invention is medical polyurethane.
In step S102, in the environmentally friendly grade Silica hydrogel B component added with curing agent provided in an embodiment of the present invention, Gu Agent, environmentally friendly grade Silica hydrogel mass ratio be 1:1.
In step S104, the Elastic bandage provided in an embodiment of the present invention is by elastic force non-woven fabrics, natural emulsion coating It is constituted with cotton yarn surface layer.
The application method of Silica hydrogel scar plaster provided in an embodiment of the present invention, specifically:
(1) scar plaster should use at least 12 hours daily, use within best 24 hours, persistently use 2~4 months；
(2) to avoid skin allergy, gradual plaster application method can be used, adapts to skin gradually；
(3) every can be Reusability 14~28 days, when scar plaster become difficult to clean or paste when, just need to change another New scar plaster.
Gradual plaster application method provided in an embodiment of the present invention is initial two days application 4 hours daily, and two days later every Its application 8 hours, is incremented by 2 hours thereafter daily, until can be applied with whole day 24 hours.
The application method of Silica hydrogel scar plaster provided in an embodiment of the present invention, specifically:
(1) scar plaster should use at least 12 hours daily, use within best 24 hours, persistently use 2~4 months；
(2) to avoid skin allergy, gradual plaster application method can be used, adapts to skin gradually；
(3) every can be Reusability 14~28 days, when scar plaster become difficult to clean or paste when, just need to change another New scar plaster.
Gradual plaster application method provided in an embodiment of the present invention is initial two days application 4 hours daily, and two days later every Its application 8 hours, is incremented by 2 hours thereafter daily, until can be applied with whole day 24 hours.
The working principle of stock gel scar plaster provided by the invention:
Since the moisture-vapor transmission of scar plaster is not as good as the half of normal skin, the storage for making cuticula have water stayed, and skin is inhaled After receiving moisture, it is suppressed that the regeneration of capillary, to reduce the deposition of collagen；Meanwhile keratoderma water content Increase can be such that water soluble protein and product Penetration ration in cutin increases, and spread rapidly, scar is promoted to soften fading, pigment It shoals, mitigates itch pain.It is demonstrated experimentally that the silicone oil slowly released in pellosil can inhibit fiber finer in cicatricial tissue The increase of born of the same parents, thus the formation of Inhibiting proliferation scar.
Application principle of the invention is further described combined with specific embodiments below.
Clinical application example 1；
1, there are within 1-3 months patient 60 of hyperplastic scar after selection burn wound healing, wherein male 46, women 14, the age 6-55 years old, the course of disease 1 month to 2 years, the chronic diseases person such as no cardiopulmonary, liver, kidney, and energy voluntary cooperation person, it carries out Tracking treatment observation is randomly divided into group on probation and each 30 comparisons of control group.
2, two groups of keliod patients use comparison: the Silica hydrogel Chinese medicine of group selection suitable size on probation controls scar Elastic bandage, pastes The hyperplastic scar surface cleaned or sterilized is invested, then Elastic bandage is uniformly tensed to pressurization, is resistant to patient, not shadow Far-end of limb blood fortune is rung for degree, and then the velcro fastener on Elastic bandage is fixed on zone face wool fabric, uses 4h；It unclamps 20h or more is recycled in 1h daily, treats 3 months.Control group is equally to cleaning or the hyperplastic scar surface sterilized, selection The pure silicon gel bonding die of suitable size, and wrapped up with Elastic bandage, it is same that 20h or more is recycled daily, it treats 3 months.
Criterion of therapeutical effect and result:
1, curative effect determinate standard: effectively: pruritis is substantially reduced at surface of a wound scar, and pain, scorching hot, girdle sensation disappear, Scar color gradually switchs to purple or brown to close to normally by red.Scar superficial capillary vessels die down, and scar softens, Thickness reduces, and does not continue to hyperplasia, affected joints function is obviously improved or returns to normal.It is invalid: scabies at surface of a wound scar Pain symptom, color, thickness itch without substantially changeing.
2, result: 60 hyperplastic scar patients, after group on probation controls the fixed pressurization of scar Elastic bandage using Silica hydrogel Chinese medicine, Patient feels comfortable, and most of scorching hot pain symptom of patient disappears, and surprise is itched substantially reduced, and scar hyperemia decline, color gradually approaches Normally, superficial capillary vessels disappear, and scar softens, thickness reduces, do not continue to hyperplasia, are within efficient 1 month 75%, and 3 months When be 98.5%.And control group is respectively 38.56% and 63.1%.Over the course for the treatment of, 60 patients try out group and control group Do not occur the side reactions such as erythema papule, difference has conspicuousness (p&lt；0.05).
Embodiment 2；
Silica hydrogel Chinese medicine treats the applied analysis of scar Elastic bandage:
Silica hydrogel Chinese medicine, which controls scar Elastic bandage, has conspicuousness (p&lt with the Silica hydrogel bonding die contrast difference that Chinese medicine is not added； 0.05).Silica hydrogel Chinese medicine controls scar Elastic bandage Contrast on effect and evaluation: the prevention and treatment of hyperplastic scar is a difficulty of medical domain Topic, there are many traditional control method, mainly have injection steroid hormones and external application silica gel in scar to control scar patch etc., these Although method effect also has, early stage sufferings remission is unobvious, is only applicable to the prevention and treatment of local small area scar, and secondary work With big, patient is not easily accepted by.And Silica hydrogel Chinese medicine of the invention controls scar Elastic bandage, it is solid using translucent environmentally friendly grade A, B mixing SiClx gel has good physiological inertia, non-stimulated to skin, nontoxic；It controls after scar traditional Chinese medicine fine powder end mixes with silicone oil Effective ingredient can slowly be precipitated, 90% is reached to scar cell-wall breaking ratio.Effective component, which is easy to extract, to be also easy directly to be absorbed, Remove scar proliferation cell and fibrosis connective tissue safely, reach radical cure scar purpose, and silica gel Chinese medicine controls scar elastic force After the fixed pressurization of bandage, patient feels comfortable, and most of scorching hot pain symptom of patient disappears, and surprise is itched substantially reduced, and scar is congested Decline, gradually close to normal, superficial capillary vessels disappearance, scar softens color, thickness reduces, does not continue to hyperplasia, 1 efficient The moon is 98.5% when being 75%, 3 months, and the present invention, which basically reaches, cures scar purpose.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (9)

1. a kind of Silica hydrogel scar plaster, which is characterized in that the Silica hydrogel scar plaster is by medical polyurethane 30%, silica gel 30% It is formed with traditional Chinese medicine ingredients.
2. Silica hydrogel scar plaster as described in claim 1, which is characterized in that the traditional Chinese medicine ingredients are according to mass fraction by beneficial female 10~50 parts of grass, 10~50 parts of Radix Salviae Miltiorrhizae, 10~50 parts of Rhizoma Chuanxiong, 8~25 parts of Radix Angelicae Sinensis, 6~20 parts of safflower, 6~20 parts of aloe compositions.
3. a kind of preparation method of Silica hydrogel scar plaster, which is characterized in that the preparation method of the Silica hydrogel scar plaster, specifically The following steps are included:
Step 1: 10~50 parts of motherwort, 10~50 parts of Radix Salviae Miltiorrhizae, 10~50 parts of Rhizoma Chuanxiong, 8~25 parts of Radix Angelicae Sinensis, safflower 6~20 are taken Part, 6~20 parts of aloe；Mixing is pulverized, and obtains medium particle diameter in 10~15 μm of Chinese medicine crushed materials below；
Step 2: according to the mass fraction, first by environmentally friendly 100~500 parts of grade Silica hydrogel component A, added with the environmentally friendly grade silicon of curing agent 100~500 parts of gel B component uniform in respective container for stirring respectively；Thereafter by environmentally friendly grade Silica hydrogel component A and B component with 20~100 parts of Chinese medicine crushed material mixing stirs evenly, and obtains the mixture of Silica hydrogel and Chinese medicine crushed material；
Step 3: the mixture of Silica hydrogel and Chinese medicine crushed material is put into deaeration 5min in the vacuum tank of 0.08MPa, is treated The Silica hydrogel Chinese medicine matrix of scar；
Silica hydrogel Chinese medicine matrix: being coated in the cotton yarn surface layer of Elastic bandage by step 4 with coating machine, is coated in Silica hydrogel The layer of medicine matrix with a thickness of 2 millimeters, thereafter only putting normal temperature laboratory solidification, obtain Silica hydrogel Combined with Chinese Herbal prescription control scar apply Material.
4. the preparation method of Silica hydrogel scar plaster as claimed in claim 3, which is characterized in that in the step 1, polyurethane For medical polyurethane.
5. the preparation method of Silica hydrogel scar plaster as claimed in claim 3, which is characterized in that described in the step 2 In environmentally friendly grade Silica hydrogel B component added with curing agent, curing agent, environmentally friendly grade Silica hydrogel mass ratio be 1:1.
6. the preparation method of Silica hydrogel scar plaster as claimed in claim 3, which is characterized in that described in the step 4 Elastic bandage is made of elastic force non-woven fabrics, natural emulsion coating and cotton yarn surface layer.
7. the preparation method of Silica hydrogel scar plaster as claimed in claim 3, which is characterized in that in the step 1, gather Urethane is medical polyurethane.
8. a kind of application method of Silica hydrogel scar plaster as described in claim 1, which is characterized in that the Silica hydrogel scar plaster Application method, specifically:
(1) scar plaster should use at least 12 hours daily, use within best 24 hours, persistently use 2~4 months；
(2) to avoid skin allergy, using gradual plaster application method, adapt to skin gradually；
(3) every can be Reusability 14~28 days, when scar plaster becomes difficult to clean or paste, just need to change another it is new Scar plaster.
9. the application method of Silica hydrogel scar plaster as claimed in claim 4, which is characterized in that the gradual plaster application method For initial two days, application 4 hours, two days later daily applications 8 hours were incremented by 2 hours thereafter, daily until can be with whole day daily It applies within 24 hours.
CN201910030004.7A 2019-01-14 2019-01-14 A kind of Silica hydrogel scar plaster and preparation method Withdrawn CN109528911A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114272227A (en) * 2022-01-17 2022-04-05 周建大 Aspirin-containing scar patch and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114272227A (en) * 2022-01-17 2022-04-05 周建大 Aspirin-containing scar patch and preparation method thereof

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Application publication date: 20190329