CN109523515A - The calculation method of blood flow reserve score - Google Patents
The calculation method of blood flow reserve score Download PDFInfo
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- CN109523515A CN109523515A CN201811216740.3A CN201811216740A CN109523515A CN 109523515 A CN109523515 A CN 109523515A CN 201811216740 A CN201811216740 A CN 201811216740A CN 109523515 A CN109523515 A CN 109523515A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10081—Computed x-ray tomography [CT]
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
- G06T2207/30104—Vascular flow; Blood flow; Perfusion
Abstract
The present invention proposes a kind of calculation method of blood flow reserve score, includes the following steps: Image Acquisition: passing through several blood-vessel images of CT Scanner continuous acquisition；It establishes the first model: establishing the first model based on several described blood-vessel images；It determines narrow section: narrow section is determined by first model；It establishes the second model: eliminating the narrow section of first model；It calculates FFR: blood flow reserve score being calculated using formula F FR=Pd/Pa, wherein Pd is the blood pressure of narrow section in the first model, and Pa is the blood pressure of blood vessel corresponding with the narrow section of the first model in the second model.The beneficial effects of the present invention are: it does not need that patient will not be caused using the drug of expansion blood vessel wound physiologically in the process, has the characteristics that safe and convenient, result are accurate.
Description
Technical field
The present invention relates to medical field more particularly to a kind of calculation methods of blood flow reserve score.
Background technique
Blood flow reserve score (Fractional Flow Reserve, FFR) is an evaluation coronary artery stenosis lesion pair
The index that vascular function influences.Refer to that coronary artery institute is theoretically normal for myocardial region there are in the case where stenotic lesion
In the case of can be obtained the ratio between maximum blood flow.Normal resistance very little of the epicardial coronary arteries to blood flow, the normal value of FFR
It is 1.0；Show that current epicardial coronary has the presence of stenotic lesion when the value of FFR is less than 1.0.
When FFR < 0.75, the narrow situation of representative almost will lead to myocardial ischemia；When FFR >=0.75, the narrow of representative is made
A possibility that at myocardial ischemia, is smaller.
Traditionally, obtained using Pressure wire it is narrow before and after blood pressure with have invasively measure FFR value.For hat
Shape artery FFR value inserts the catheter into femoral artery or radial artery using sheath and seal wire during coronary catheter insertion.Attachment
Sensor to tip is placed on interested stenosis, and by influence blood vessel geometry, compliance and repellence
And/or other features various medicaments promote the case where during, be recorded in the pressure at narrow both ends.This mode has certain wind
Danger, for example, for it is very narrow it is narrow for, Pressure wire may induce additional pressure drop.And it needs to take expansion when FFR measurement
Blood vessel drug eluting, some patients have adverse reaction.In addition, dose of radiation is big when FFR is measured and somewhat expensive.
In the prior art, it is pressed using insertion type mode by acquisition such as the patent document of Publication No. CN102905614A
Power and speed calculate FFR value with integral way；For another example in the patent document of Publication No. CN103829933A, by by two
Pressure sensor is intervened in human vas, measures the numerical value of two pressure sensors respectively, is surveyed according to the two pressure sensors
The pressure difference of numerical quantity to judge whether to occur between the two pressure sensors hemadostewnosis, and is arranged by threshold value, will be surveyed
Amount result reports and submits diagnosis.Aforesaid way obtains the value of FFR by insertion type, and usage range is limited, and brings to patient
Biggish pain.
In view of the above drawback, it is really necessary to provide a kind of calculation method of blood flow reserve score to overcome disadvantages described above.
Summary of the invention
The purpose of the present invention is to provide a kind of calculation methods of blood flow reserve score, to overcome in above-mentioned background technique
It is insufficient at least one.
To achieve the goals above, the present invention proposes a kind of calculation method of blood flow reserve score, includes the following steps:
Image Acquisition: pass through several blood-vessel images of CT Scanner continuous acquisition；
It establishes the first model: establishing the first model based on several described blood-vessel images；
It determines narrow section: narrow section is determined by first model；
It establishes the second model: eliminating the narrow section of first model；
It calculates FFR: blood flow reserve score being calculated using formula F FR=Pd/Pa, wherein Pd is narrow section in the first model
Blood pressure, Pa is the blood pressure of blood vessel corresponding with the narrow section of the first model in the second model.
In a preferred embodiment, in the step of described image acquires, the angiographic image has can
Determine that main coronary artery starts the resolution ratio at least third branch point.
In a preferred embodiment, it is established in the first model and described the step of establishing the second model described, institute
Stating the first model and second model is Three-Dimensional Dynamic model.
In a preferred embodiment, in described the step of establishing the first model, include the following steps:
Extract the Pixel Information of vessel profile；
Unitized processing is carried out to the Pixel Information of vessel profile, establishes blood vessel surface model；
It is carried out according to the reduction of the physical characteristic of vessel profile point and blood vessel structure to blood vessel dynamic simulation.
In a preferred embodiment, in the determining narrow section the step of, include the following steps:
It carries out curve fitting to the cross-sectional diameter of the blood vessel；
The low spot of the matched curve is extracted as suspected blood vessel narrow point；
Determine the left margin and right margin of the suspected blood vessel narrow section where suspected blood vessel narrow point.
In a preferred embodiment, the step of the cross-sectional diameter to the blood vessel carries out curve fitting
In, include the following steps:
Determine the direction that the blood vessel extends；
Obtain the diameter of each cross section of the blood vessel；
Using the position of the cross section of the blood vessel as X-coordinate, corresponding cross section diameter as Y-coordinate, be fitted to
Curve.
In a preferred embodiment, in the low spot for extracting the matched curve as suspected blood vessel narrow point
In step, include the following steps:
The first derivative and second dervative of every bit on digital simulation curve, by first derivative be 0 and second dervative is 0
Point is used as inflection point；
N number of point adjacent on the left of inflection point in the matched curve is selected, is selected adjacent on the right side of inflection point in the matched curve
N number of point；
Judge whether the Y-coordinate of inflection point is less than the Y-coordinate that each in the selected 2N point of previous step is put, if so,
Then using the inflection point as low spot.
In a preferred embodiment, in described the step of establishing the second model, based on adjacent non-narrow blood vessel
Property carries out normalization to the narrow section to eliminate the narrow section.
Compared with prior art, the beneficial effect of the calculation method of blood flow reserve score provided by the invention is: by
Blood vessel CT image establishes the first model and the second model of blood vessel, and the second model eliminates the narrow section of the first model, by obtaining
The blood pressure for taking blood vessel corresponding with the narrow section of the first model in the blood pressure and the second model of the first model narrow section, in conjunction with
FFR empirical equation calculates blood flow reserve score；It does not need to cause patient using the drug of expansion blood vessel in the process
Wound physiologically has the characteristics that safe and convenient, result are accurate.
Detailed description of the invention
Fig. 1 is the flow diagram of the calculation method of blood flow reserve score of the present invention；
Fig. 2 is the flow diagram of the calculation method of blood flow reserve score of the present invention；
Fig. 3 is the flow diagram of the calculation method of blood flow reserve score of the present invention；
Fig. 4 is the flow diagram of the calculation method of blood flow reserve score of the present invention；
Fig. 5 is the flow diagram of the calculation method of blood flow reserve score of the present invention.
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute is only used in the embodiment of the present invention
In explaining in relative positional relationship, the motion conditions etc. under a certain particular pose (as shown in the picture) between each component, if should
When particular pose changes, then directionality instruction also correspondingly changes correspondingly, and the connection, which can be, to be directly connected to,
It can be and be indirectly connected with.
In addition, the description for being related to " first " " second " etc. in the present invention is used for description purposes only, and should not be understood as referring to
Show or imply its relative importance or implicitly indicates the quantity of indicated technical characteristic." first " " is defined as a result,
Two " feature can explicitly or implicitly include at least one of the features.In addition, the technical solution between each embodiment can
It to be combined with each other, but must be based on can be realized by those of ordinary skill in the art, when the combination of technical solution occurs
Conflicting or cannot achieve when, will be understood that the combination of this technical solution is not present, also not the present invention claims protection model
Within enclosing.
Fig. 1 is please referred to, the present invention provides a kind of calculation method of blood flow reserve score, includes the following steps:
S01, Image Acquisition；
S02, the first model is established；
S03, narrow section is determined；
S04, the second model is established；
S05, FFR is calculated.
Such as the step S01, Image Acquisition passes through several blood-vessel images of CT Scanner continuous acquisition；The blood vessel refers to
Be arteries, including coronary artery；The blood-vessel image, which has, can determine that main coronary artery starts at least third point
The resolution ratio of fulcrum.Preferably, the blood-vessel image is CT angiographic image, has invasive small, handy and safe and image
Clear feature.
Such as the step S02, the first model is established, establishes the first model based on several described blood-vessel images, it will be static
Two dimensional image be converted into Three-Dimensional Dynamic model.
Such as the step S03, determines narrow section, narrow section is determined by first model, i.e., with first model
Based on, determine the narrow section in blood vessel.
Such as the step S04, the second model is established, eliminates the narrow section of first model, i.e., with first model
Based on, the narrow section in the blood vessel in first model is eliminated；Second model is Three-Dimensional Dynamic model.
Such as the step S05, FFR is calculated, using formula F FR=Pd/PaCalculate blood flow reserve score, wherein PdIt is first
The blood pressure of narrow section, P in modelaIt is the blood pressure of blood vessel corresponding with the narrow section of the first model in the second model.
Referring to figure 2., in the calculation method of the blood flow reserve score, described the step of establishing the first model, including
Step:
S21, the Pixel Information for extracting vessel profile；
S22, unitized processing is carried out to the Pixel Information of vessel profile, establishes blood vessel surface model；
S23, it is carried out according to the physical characteristic of vessel profile point and the reduction of blood vessel structure to blood vessel dynamic simulation.
Such as the step S21, the Pixel Information of vessel profile is extracted, by three-dimensional spatial area growth method from image sequence
The Pixel Information of vessel profile is extracted in information；The three-dimensional spatial area growth method includes: to be partitioned into image sequence information
One target area, is manually arranged a sub-pixel point, which is (x0, y0)；Centered on (x0, y0), consider (x0,
Y0 26 neighborhood territory pixels (x, y)) are pressed into storehouse if (x, y) meets baffle criterion, by point (x, y)；One is taken out from storehouse
Pixel is considered as (x0, y0), and repetitive operation then takes a sub-pixel point to repeat aforementioned behaviour again until when storehouse is empty
Make step；Finally until each point has ownership in image sequence.
Such as the step S22, unitized processing is carried out to the Pixel Information of vessel profile, establishes blood vessel surface model；Packet
It includes and the control vertex that the building processing of cumulative inborn curve obtains vessel profile is carried out according to the Pixel Information of vessel profile；According to blood
The control vertex of pipe profile carries out angular samples processing, obtains unitized rear new blood vessel tomography profile point；According to new blood vessel
Profile point re-starts cumulative inborn curve building processing, obtains new blood vessel tomography profile control point；It is disconnected to obtain new blood vessel
Layer profile control point carries out blood vessel modeling, obtains blood vessel surface model.
Such as the step S23, carried out according to the reduction of the physical characteristic of vessel profile point and blood vessel structure to blood vessel dynamic
Emulation.The emulation of reduction blood vessel structure and physical characteristic is carried out using DNURBS algorithm.In any fixed time, vessel profile is permanent
For nurbs curve, therefore all features with nurbs curve.Due to the introducing of time parameter, so that vessel profile curve has
There is dynamic physical feature, by the state of the profile point on current time and previous moment blood vessel, derives subsequent time blood vessel
The state of upper profile point, to obtain real-time dynamic simulation process.
Referring to figure 3., in the calculation method of the blood flow reserve score, the step of the determining narrow section, including step
It is rapid:
S31, it carries out curve fitting to the cross-sectional diameter of the blood vessel；
S32, extract the fitting curve low spot as suspected blood vessel narrow point；
S33, the left margin and right margin for determining suspected blood vessel narrow section where suspected blood vessel narrow point.
Referring to figure 4., it such as the step S31, carries out curve fitting to the cross-sectional diameter of the blood vessel, the curve of fitting
Information including the cross-sectional diameter of corresponding position on the blood vessel, includes the following steps:
S311, the direction that the blood vessel extends is determined；Using the position of the blood vessel initial cross sectional as coordinate origin, other
The position of cross section is the distance relative to initial cross sectional.
The diameter of each cross section of S312, the acquisition blood vessel；Calculate two of the vessel cross-sections and vascular wall
The distance of intersection point.
S313, using the position of the cross section of the blood vessel as X-coordinate, corresponding cross section diameter as Y-coordinate, intend
Resultant curve.
Referring to figure 5., such as the step S32, the low spot of the curve of the fitting is extracted as suspected blood vessel narrow point, packet
Include following steps:
First derivative is 0 and second dervative by the first derivative and second dervative of every bit on S321, digital simulation curve
For 0 point as inflection point；
N number of point adjacent on the left of inflection point, selects in the matched curve on the right side of inflection point on S322, the selection matched curve
Adjacent N number of point, wherein N is positive integer, it is preferable that N is the positive integer greater than 3 and less than 10；
S323, judge whether the Y-coordinate of inflection point is less than the Y-coordinate that each in the selected 2N point of previous step is put,
If so, using the inflection point as low spot.
Such as the step S33, the left margin and right margin of the suspected blood vessel narrow section where suspected blood vessel narrow point are determined,
The absolute value that the slope of curve is found on the left of the suspected blood vessel narrow point is less than or equal to the point of a preset value as the left side
Boundary；The absolute value that the slope of curve is found on the right side of the suspected blood vessel narrow point is less than or equal to the point of a preset value as right
Boundary；The preset value can be 0, be also possible to be approximately 0 value, such as 0.1.
Further, described to establish the second model in the calculation method of the blood flow reserve score, eliminate described first
The step of narrow section of model, the property based on adjacent non-narrow blood vessel carry out normalization to the narrow section to described in elimination
Narrow section, i.e., described second model are normal vascular pattern.It in other embodiments, can also be by changing first mould
The mode of the cross-sectional diameter of narrow section eliminates the narrow section and obtains second model in type.
A kind of calculation method of blood flow reserve score provided by the invention, passes through several blood vessels of CT Scanner continuous acquisition
Image establishes the first model according to several blood-vessel images, the blood vessel in the first model is determined by way of curve matching
Narrow section blood vessel normalization based on another first model, is established the second model, obtained narrow in the first model by narrow section
Narrow section of blood pressure PdAnd the second blood pressure P of vascular site that is handled through normalization in modela, according to FFR empirical equation: FFR
=Pd/PaCalculate blood flow reserve score.It does not need that patient will not be caused to give birth to using the drug of expansion blood vessel in whole process
Wound in reason has the characteristics that safe and convenient, result are accurate.
The above description is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, all utilizations
Equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content is applied directly or indirectly in other correlations
Technical field, be included within the scope of the present invention.
Claims (8)
1. a kind of calculation method of blood flow reserve score, which comprises the steps of:
Image Acquisition: pass through several blood-vessel images of CT Scanner continuous acquisition；
It establishes the first model: establishing the first model based on several described blood-vessel images；
It determines narrow section: narrow section is determined by first model；
It establishes the second model: eliminating the narrow section of first model；
It calculates FFR: blood flow reserve score being calculated using formula F FR=Pd/Pa, wherein Pd is the blood of narrow section in the first model
Pressure, Pa is the blood pressure of blood vessel corresponding with the narrow section of the first model in the second model.
2. the calculation method of blood flow reserve score as described in claim 1, which is characterized in that in the step of described image acquires
In, the angiographic image, which has, can determine that main coronary artery starts the resolution ratio at least third branch point.
3. the calculation method of blood vessel as described in claim 1 deposit score, which is characterized in that it is described establish the first model and
In described the step of establishing the second model, first model and second model are Three-Dimensional Dynamic model.
4. the calculation method of blood flow reserve score as claimed in claim 3, which is characterized in that in first model of establishing
In step, include the following steps:
Extract the Pixel Information of vessel profile；
Unitized processing is carried out to the Pixel Information of vessel profile, establishes blood vessel surface model；
It is carried out according to the reduction of the physical characteristic of vessel profile point and blood vessel structure to blood vessel dynamic simulation.
5. the calculation method of blood vessel deposit score as described in claim 1, which is characterized in that in the step of the determining narrow section
In rapid, include the following steps:
It carries out curve fitting to the cross-sectional diameter of the blood vessel；
The low spot of the matched curve is extracted as suspected blood vessel narrow point；
Determine the left margin and right margin of the suspected blood vessel narrow section where suspected blood vessel narrow point.
6. the calculation method of blood vessel deposit score as claimed in claim 5, which is characterized in that in the cross to the blood vessel
In the step of diameter of section carries out curve fitting, include the following steps:
Determine the direction that the blood vessel extends；
Obtain the diameter of each cross section of the blood vessel；
Using the position of the cross section of the blood vessel as X-coordinate, corresponding cross section diameter as Y-coordinate, be fitted to curve.
7. the calculation method of blood vessel deposit score as claimed in claim 6, which is characterized in that extract the fitting song described
In the step of low spot of line is as suspected blood vessel narrow point, include the following steps:
The first derivative and second dervative of every bit on digital simulation curve make the point that first derivative is 0 and second dervative is 0
For inflection point；
N number of point adjacent on the left of inflection point in the matched curve is selected, is selected in the matched curve adjacent N number of on the right side of inflection point
Point；
Judge whether the Y-coordinate of inflection point is less than the Y-coordinate that each in the selected 2N point of previous step is put, if so, will
The inflection point is as low spot.
8. the calculation method of blood vessel as described in claim 1 deposit score, which is characterized in that in second model of establishing
In step, the property based on adjacent non-narrow blood vessel carries out normalization to the narrow section to eliminate the narrow section.
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| CN110477877A (en) * | 2019-07-03 | 2019-11-22 | 北京工业大学 | A method of it is established based on FFR principle and quickly judges hemadostewnosis resistance and microcirculation drag size model |
| WO2021042477A1 (en) * | 2018-09-19 | 2021-03-11 | 苏州润迈德医疗科技有限公司 | Simplified method, apparatus and system for measuring coronary artery vessel evaluation parameters |
| CN113143305A (en) * | 2020-01-22 | 2021-07-23 | 西门子医疗有限公司 | Providing a set of blood flow parameters for vascular malformations |
| CN113744246A (en) * | 2021-09-03 | 2021-12-03 | 乐普（北京）医疗器械股份有限公司 | Method and device for predicting fractional flow reserve from vascular tomography images |
| CN114897904A (en) * | 2022-07-14 | 2022-08-12 | 青岛美迪康数字工程有限公司 | Method and device for determining fractional flow reserve based on MRA sequence image |
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| CN113744246A (en) * | 2021-09-03 | 2021-12-03 | 乐普（北京）医疗器械股份有限公司 | Method and device for predicting fractional flow reserve from vascular tomography images |
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| CN114897904A (en) * | 2022-07-14 | 2022-08-12 | 青岛美迪康数字工程有限公司 | Method and device for determining fractional flow reserve based on MRA sequence image |
| CN114897904B (en) * | 2022-07-14 | 2022-10-28 | 青岛美迪康数字工程有限公司 | Method and device for determining fractional flow reserve based on MRA sequence image |
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