CN109512858A - Combination glutamine capsule and preparation method thereof - Google Patents
Combination glutamine capsule and preparation method thereof Download PDFInfo
- Publication number
- CN109512858A CN109512858A CN201811625120.5A CN201811625120A CN109512858A CN 109512858 A CN109512858 A CN 109512858A CN 201811625120 A CN201811625120 A CN 201811625120A CN 109512858 A CN109512858 A CN 109512858A
- Authority
- CN
- China
- Prior art keywords
- parts
- ginseng
- preparation
- glutamine
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 title claims abstract description 15
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 25
- 241000208340 Araliaceae Species 0.000 claims abstract description 20
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 20
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 20
- 235000008434 ginseng Nutrition 0.000 claims abstract description 20
- 244000197580 Poria cocos Species 0.000 claims abstract description 18
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 16
- 239000006071 cream Substances 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 13
- 229940107131 ginseng root Drugs 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 239000000047 product Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930182816 L-glutamine Natural products 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 9
- 229920002261 Corn starch Polymers 0.000 claims abstract description 8
- 239000008120 corn starch Substances 0.000 claims abstract description 8
- 229940099112 cornstarch Drugs 0.000 claims abstract description 8
- 238000005469 granulation Methods 0.000 claims abstract description 8
- 230000003179 granulation Effects 0.000 claims abstract description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 8
- 239000000945 filler Substances 0.000 claims abstract description 6
- 239000002245 particle Substances 0.000 claims abstract description 6
- 239000000314 lubricant Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000011812 mixed powder Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000003814 drug Substances 0.000 description 15
- 238000010438 heat treatment Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 238000011049 filling Methods 0.000 description 6
- 229920001684 low density polyethylene Polymers 0.000 description 6
- 239000004702 low-density polyethylene Substances 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 238000003801 milling Methods 0.000 description 4
- 238000005498 polishing Methods 0.000 description 4
- 241000132012 Atractylodes Species 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 231100000987 absorbed dose Toxicity 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The problem of the invention discloses Combination glutamine capsules and preparation method thereof, solve complex process in the prior art, and supplementary product consumption is big, high production cost.Combination glutamine capsule of the invention includes the following parts by weight: 120 parts of L-Glutamine, 50 parts of ginseng, 50 parts of radix glycyrrhizae preparata, 50 parts of Poria cocos, 50 parts of Rhizoma Atractylodis Macrocephalae, 3-4 parts of filler, 1-2 parts of lubricant.It is of the invention the preparation method comprises the following steps: ginseng is ground into Ginseng Root Powder；By radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos, extracting in water is filtered, and filtrate is condensed into clear cream；By Ginseng Root Powder and the clear cream mixing granulation, drying, particle is obtained；The L-Glutamine of recipe quantity, cornstarch, magnesium stearate and particle are pre-mixed, crushed, then it is mixed after uniformly after, be filled into hollow capsulae enterosolubilis, examine, pack to get finished product.Design science of the present invention, method is simple, and supplementary product consumption is few, effectively reduces production cost.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to Combination glutamine capsule and preparation method thereof.
Background technique
Combination glutamine capsule records and rises national standard the 9th in chemicals provincial standard, standard No.
For WS-10001- (HD-0836) -2002, it is made of L-Glutamine, ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata.Indication be for
Acute and chronic intestines problem caused by a variety of causes and function of intestinal canal disorder, such as irritable bowel syndrome, noninfectious diarrhea, tumour
Function of intestinal canal disorder caused by treating and radiotherapy enteritis；Also it can promote the recovery of wound or postoperative function of intestinal canal.
In the prior art, there are complex process for the preparation of Combination glutamine capsule, and supplementary product consumption is big, production cost
High problem.Therefore it provides a kind of Combination glutamine capsule and preparation method thereof, simple process, supplementary product consumption is few, at
For those skilled in the art's urgent problem to be solved.
Summary of the invention
Technical problem solved by the present invention is providing Combination glutamine capsule and preparation method thereof, solve existing
The problem of complex process in technology, supplementary product consumption is big, high production cost.
The technical solution adopted by the invention is as follows:
Combination glutamine capsule of the present invention, includes the following parts by weight: L-Glutamine 120
Part, 50 parts of ginseng, 50 parts of radix glycyrrhizae preparata, 50 parts of Poria cocos, 50 parts of Rhizoma Atractylodis Macrocephalae, 3-4 parts of filler, 1-2 parts of lubricant.
Preferably, the filler is cornstarch.
Preferably, the lubricant is magnesium stearate.
The preparation method of Combination glutamine capsule of the present invention, comprising the following steps:
Step 1. crushes: ginseng is ground into Ginseng Root Powder, it is spare；
Step 2. weighs radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos by recipe quantity, and extracting in water filters, and filtrate is condensed into clear cream；
Step 3. weighs Ginseng Root Powder by recipe quantity, with the clear cream mixing granulation, drying, obtains particle；
Particle made from the L-Glutamine of recipe quantity, cornstarch, magnesium stearate and step 3 is pre-mixed by step 4.,
It crushes, then smashed powder is mixed rear uniform, obtains mixed-powder；
The resulting mixed-powder of step 4 is filled into hollow capsulae enterosolubilis by step 5., is examined, is packed to get finished product.
Further, the partial size of the Ginseng Root Powder is 60-80 mesh.
Further, the ginseng pulverate uses after being irradiated sterilizing.
Further, three times, each amount of water is 3-6 times of medicinal material weight for the radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos extracting in water
Amount, relative density is 1.15-1.20g/cm when filtrate is concentrated into 80 DEG C3Clear cream.
Further, in the step 3, using marumerization by Ginseng Root Powder and clear cream mixing granulation, drying.
Further, it in the step 2, after radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos are soaked in water 30min, reheats and extracts.
Heretofore described radix glycyrrhizae preparata is the Preparation process product of Radix Glycyrrhizae, i.e. Chinese Pharmacopoeia (version in 2015, one) records
Radix glycyrrhizae preparata.
Heretofore described Rhizoma Atractylodis Macrocephalae is the dry of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz.
The Rhizoma Atractylodis Macrocephalae that dry rhizome, i.e. Chinese Pharmacopoeia (version in 2015, one) record.
Heretofore described Poria cocos is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf,
That is the Poria cocos that records of Chinese Pharmacopoeia (version in 2015, one).
Compared with prior art, the invention has the following advantages:
Design science of the present invention, method is simple, and supplementary product consumption is few, effectively reduces production cost.
The present invention is used as medicine after ginseng is beaten powder, that is, remains the effective component of ginseng, while powder is used as medicine and can effectively subtract
Few supplementary product consumption, reduces production difficulty and production cost.The present invention uses after ginseng sterilizes, and is effectively guaranteed medication peace
Entirely.
The present invention is mixed with clout again after people is participated in clear cream granulation, is crushed, is remixed, be effectively guaranteed the equal of drug
One property.
Detailed description of the invention
Attached drawing 1 is process flow chart of the invention.
Specific embodiment
Below with reference to embodiment and attached drawing, invention is further explained, and mode of the invention includes but are not limited to
Following embodiment.
Embodiment 1
Preparation of the invention is present embodiments provided, prescription is as shown in table 1:
Table 1
| Name of material | 1000 dosages |
| L-Glutamine | 120g |
| Ginseng Root Powder | 50g |
| Radix glycyrrhizae preparata medicine materical crude slice | 50g |
| Poria cocos medicine materical crude slice | 50g |
| Atractylodes slice | 50g |
| Cornstarch | 3.4g |
| Magnesium stearate | 1.6g |
The preparation method is as follows:
Step 1. crushes: ginseng medicine materical crude slice being set dry in heated-air circulation oven.Drying temperature: 60 ± 5 DEG C；Drying time:
Ginseng medicine materical crude slice moisture < 9.5%, it is 8 hours dry；Ginseng medicine materical crude slice moisture >=9.5%, it is 10 hours dry.It is dry to complete, it is cooling.It will
Ginseng medicine materical crude slice after drying is first crushed with 22.5mm bore diameter stainless steel stamped sieve, and is contained with clean container, then use 0.5mm
(80 mesh) stainless steel stamped sieve progress in aperture is fine crushing, sets in the double-deck medicinal low density polyethylene (LDPE) bag, prepares irradiation.
Ginseng pulverate uses60COIrradiation sterilization:60COIrradiation sterilization irradiation devices parameter: 2'40 " × 6~4'40 " × 6；It is conventional
The distributing position and quantity of dosimeter are set to 5 points of distributions；Minimal absorption dosage: 6.10kGy~7.9kGy；Maximum absorbed dose:
6.95kGy~9.02kGy；Ensemble average dosage: 6.49kGy~8.45kGy；X-ray unsymmetry: 1.073~1.221, it is maximum
Population mean irradiation dose must not exceed 10kGy.
Step 2. weighs radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos by recipe quantity, and 5 times of water of medicinal material weight are added, after impregnating 30 minutes,
Open steam valve heating, Steam pressure control when heating :≤0.2MPa.After temperature reaches 80 DEG C, circulation is opened, circulation is about
3min.When being heated to 95 DEG C, start timing, temperature is controlled at 95 ± 5 DEG C, decocted 2 hours.After decoction, decocting liquid is passed through
100 mesh net filtrations, are pumped into storage tank.
Second of decoction: add 1.35m3(5 times of medicinal material weight) drinking water opens steam valve heating, steam when heating
Pressure control :≤0.2MPa.After temperature reaches 80 DEG C, circulation is opened, recycles about 3min.When being heated to 95 DEG C, start timing,
Temperature is controlled at 95 ± 5 DEG C, is decocted 1.5 hours.After decoction, by decocting liquid by 100 mesh net filtrations, it is pumped into storage tank,
Filtrate is decocted with first time to merge.
Third time decocts: adding 0.81m3(3 times of medicinal material weight) drinking water opens steam valve heating, steam when heating
Pressure control :≤0.2MPa.After temperature reaches 80 DEG C, circulation is opened, recycles about 3min.When being heated to 95 DEG C, start timing,
Temperature is controlled at 95 ± 5 DEG C, is decocted 0.5 hour.After decoction, by decocting liquid by 100 mesh net filtrations, it is pumped into storage tank,
Merge with the preceding filtrate of decoction twice.
Concentration:
Be concentrated under reduced pressure: opening dual-effect concentrator vacuum, vacuum degree: >=0.05MPa will decoct filtrate from storage tank and be pumped into economic benefits and social benefits
In inspissator, when decoction filtrate liquid level reaches manhole 1/2 position of mirror, stops decocting filtrate suction, open steam, be concentrated.When
When extracting solution liquid level is concentrated into lower section 1/3 position of visor in one effect inspissator/bis- effect inspissators, continue to be pumped into decoction filtrate to people
1/2 position of aperture mirror, continues to be concentrated.It is pumped into repeatedly and decocts filtrate concentration, until complete by filtrate is decocted in storage tank and two effect inspissators
Portion is transferred in an effect inspissator.Concentration about 3.5 hours, sample detection concentrate relative density, when relative density reaches 1.05
~1.15g/cm3When (medicinal extract temperature 80 DEG C ± 2 DEG C detection), close vacuum.State modulator is concentrated under reduced pressure: steam pressure is maintained at
Between≤0.2MPa；One effect temperature: 70~90 DEG C, vacuum degree: 0.03~0.06MPa；Two effect temperature: 50~70 DEG C, vacuum degree:
0.05~0.08MPa.
Normal pressure concentration: keep the temperature 1 hour at 90 DEG C or more or more, when relative density reaches 1.15~1.20g/cm3When (medicinal extract
Temperature is measured at 80 DEG C ± 2 DEG C), start to receive cream.
Receive cream: after medicinal extract is sieved by 100 mesh stainless steels, with can closed stainless steel barrel contain, weigh, identify, cover it is close
It closes, is transferred to intermediate station and stores for future use.
Step 3.Ginseng pulverate is put into FLB-150C Fluidbedgranulatingdrier pot, Fluidbedgranulatingdrier, air inlet are opened
Temperature setting: 90 DEG C, control inlet air temperature: 80~100 DEG C, blower frequency: 20Hz, tremble a bag parameter setting: 120S is trembled bag 6 times,
Ginseng pulverate is preheated to 50 DEG C of temperature of charge or more, in the case where keeping fluidized state, medicinal extract is sprayed into peristaltic pump, it is dry to carry out granulation
It is dry.Granulation, drying parameter: control inlet air temperature: 60~100 DEG C, keep temperature of charge: 50~80 DEG C, according to temperature of charge and
Goods fluid status adjustment blower frequency: 20~45Hz, hydrojet frequency: 120~220rpm, pressure of shooting: 0.2~0.3Mpa,
Atomizing pressure: 0.2~0.3Mpa.
After medicinal extract has sprayed, blower frequency is adjusted to 35~45Hz, control inlet air temperature: 80~100 DEG C, after dry,
Sample tap sampling detects material moisture, moisture≤4.0% with fast tester for water content.Fast tester for water content parameter setting: add
Hot temperature: 105 DEG C；End mode: automatic 30s；Heating method: standard.3~5g of sample size.
After moisture reaches requirement, heating is closed, temperature of charge is down to 37 DEG C hereinafter, rewinding.With the double-deck medicinal low-density
Polythene Bag installs, and tightens interior external bag opening respectively, sticks mark, is transferred to intermediate station storage.
Step 4. premix: according to L-Glutamine, the precedence of cornstarch, magnesium stearate, extract powder, it is pumped into FZH-
The type side 1000L bores in mixing machine, mixing machine revolving speed: 12 revs/min, setting hybrid parameter: total run time: 5 minutes；When rotating forward
Between: 150 seconds；Reversing time: 150 seconds；Star triangle conversion time: 10 seconds.Open equipment, mixing.After mixing, material is put
Enter in clean container, covers mark, be transferred between crushing.
Milling: the material after will be just mixed is pumped into 30BVI type dust suction shredder hopper, is opened and is crushed unit, with the hole 1.5mm
Diameter stainless steel stamped sieve milling.Feeding parameter setting: the material time: 9s, discharging time: 3s is taken out.After milling, contained with stainless steel barrel
Dress is transferred to mixed room after covering mark.
Total mix: the mixed powder after milling is pumped into the type side FZH-1000L cone mixing machine, mixing machine revolving speed: 12 revs/min,
Set hybrid parameter: total run time: 20 minutes；The rotating forward time: 600 seconds；Reversing time: 600 seconds；Star triangle conversion time:
10 seconds.Open equipment, mixing.After having mixed, material is released, is contained with 2 layers of medicinal low density polyethylene (LDPE) bag, is tightened respectively inside and outside
Bag sack, weighs, sticks mark, be transported between gas lock, and barrelling mark is transferred to pharmaceutical workshop.
Step 5. equipment debugging: after full-automatic hard capsule filling machine idle running is normal, the hollow glue of 2# enteric gelatin is put into
Capsule, mixed powder, adjust 6 groups of filling bar depth, spot-check the simple grain anther sac weight of 1 group of filling bar capsule, after qualified, continue filling at least
The simple grain anther sac weight of one circle metering disk quantity capsule, and check capsule appearance, could formally it be filled after qualification.
Automatic hard capsule filler state modulator: filling machine revolving speed: 1000~2800/minute；Compressed air pressure:
0.5~0.7Mpa；Branch sac vacuum degree: 0.02~0.05Mpa.
Polishing lamp inspection: the capsule after filling carries out polishing and inspection rejects (empty pocket and half-capsules) with polishing machine, then manually
It is checked on lamp inspection desk, picks out the underproof capsule of the appearances such as split, flat capsule, empty pocket, long capsule.Qualified glue after selecting
Capsule is packed into the clean container for being lined with the double-deck medicinal low density polyethylene (LDPE) bag, tighten sack, weigh, enclose mark, is transported to
Between station by batch leaving concentratedly.After the assay was approved to get finished product.
Embodiment 2
Preparation of the invention is present embodiments provided, prescription is as shown in table 2:
Table 2
| Name of material | 1000 dosages |
| L-Glutamine | 120g |
| Ginseng Root Powder | 50g |
| Radix glycyrrhizae preparata medicine materical crude slice | 50g |
| Poria cocos medicine materical crude slice | 50g |
| Atractylodes slice | 50g |
| Cornstarch | 3g |
| Magnesium stearate | 2g |
The preparation method is the same as that of Example 1.
Embodiment 3
Preparation of the invention is present embodiments provided, prescription is as shown in table 3:
Table 3
| Name of material | 1000 dosages |
| L-Glutamine | 120g |
| Ginseng Root Powder | 50g |
| Radix glycyrrhizae preparata medicine materical crude slice | 50g |
| Poria cocos medicine materical crude slice | 50g |
| Atractylodes slice | 50g |
| Cornstarch | 4g |
| Magnesium stearate | 1g |
The preparation method is the same as that of Example 1.
Above-described embodiment is only one of the preferred embodiment of the present invention, should not be taken to limit protection model of the invention
It encloses, as long as that in body design thought of the invention and mentally makes has no the change of essential meaning or polishing, is solved
The technical issues of it is still consistent with the present invention, should all be included within protection scope of the present invention.
Claims (9)
1. Combination glutamine capsule, which is characterized in that include the following parts by weight: 120 parts of L-Glutamine, people
50 parts, 50 parts of radix glycyrrhizae preparata, 50 parts of Poria cocos, 50 parts of Rhizoma Atractylodis Macrocephalae, 3-4 parts of filler, 1-2 parts of lubricant of ginseng.
2. Combination glutamine capsule according to claim 1, which is characterized in that the filler is corn shallow lake
Powder.
3. Combination glutamine capsule according to claim 1 or 2, which is characterized in that the lubricant is tristearin
Sour magnesium.
4. the preparation method of Combination glutamine capsule according to claim 1 to 3, which is characterized in that
The following steps are included:
Step 1. crushes: ginseng is ground into Ginseng Root Powder, it is spare；
Step 2. weighs radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos by recipe quantity, and extracting in water filters, and filtrate is condensed into clear cream；
Step 3. weighs Ginseng Root Powder by recipe quantity, with the clear cream mixing granulation, drying, obtains particle；
Particle made from the L-Glutamine of recipe quantity, cornstarch, magnesium stearate and step 3 is pre-mixed by step 4., is crushed,
It is again that smashed powder is mixed rear uniform, obtain mixed-powder；
The resulting mixed-powder of step 4 is filled into hollow capsulae enterosolubilis by step 5., is examined, is packed to get finished product.
5. the preparation method according to claim 4, which is characterized in that the partial size of the Ginseng Root Powder is 60-80 mesh.
6. the preparation method according to claim 4, which is characterized in that the ginseng pulverate uses after being irradiated sterilizing.
7. the preparation method according to claim 4, which is characterized in that the radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos extracting in water three
Secondary, each amount of water is that 3-6 times of medicinal material weight is measured, and relative density is 1.15-1.20g/cm when filtrate is concentrated into 80 DEG C3It is clear
Cream.
8. the preparation method according to claim 4, which is characterized in that in the step 3, using marumerization by ginseng
Powder and clear cream mixing granulation, drying.
9. the preparation method according to claim 4, which is characterized in that in the step 2, radix glycyrrhizae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos are added
After water impregnates 30min, reheats and extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625120.5A CN109512858A (en) | 2018-12-28 | 2018-12-28 | Combination glutamine capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625120.5A CN109512858A (en) | 2018-12-28 | 2018-12-28 | Combination glutamine capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109512858A true CN109512858A (en) | 2019-03-26 |
Family
ID=65798404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811625120.5A Pending CN109512858A (en) | 2018-12-28 | 2018-12-28 | Combination glutamine capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109512858A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007048A (en) * | 2006-01-23 | 2007-08-01 | 地奥集团成都药业股份有限公司 | Preparation method of a compound glutamine medicine composition |
| CN102697845A (en) * | 2010-10-15 | 2012-10-03 | 佳木斯大学 | Compound polysaccharide traditional Chinese medicine microecological regulator |
-
2018
- 2018-12-28 CN CN201811625120.5A patent/CN109512858A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007048A (en) * | 2006-01-23 | 2007-08-01 | 地奥集团成都药业股份有限公司 | Preparation method of a compound glutamine medicine composition |
| CN102697845A (en) * | 2010-10-15 | 2012-10-03 | 佳木斯大学 | Compound polysaccharide traditional Chinese medicine microecological regulator |
Non-Patent Citations (1)
| Title |
|---|
| 王娴: "复方谷氨酰胺预防和治疗小儿肺炎继发腹泻的临床疗效", 《中国医学创新》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106580889B (en) | Angelica sinensis formula granular preparation and preparation method thereof | |
| CN102526660A (en) | Chinese medicine health wine and preparation method thereof | |
| CN109223882A (en) | The drug and its preparation process for treating menalgia | |
| CN109512858A (en) | Combination glutamine capsule and preparation method thereof | |
| CN114344418B (en) | Industrial process method of stable radix astragali hypoglycemic composition | |
| CN109091517A (en) | The preparation method of Gucining eapsule | |
| CN105497161B (en) | Bezoar soft capsule for detoxifying | |
| CN105031010B (en) | Ganoderma lucidum leech capsule and its preparation method and application | |
| CN112914009A (en) | Health-care solid beverage for yang-deficiency constitution and preparation method thereof | |
| CN108452051A (en) | A kind of menstruation-regulating face-beautifying pharmaceutical capsules and preparation method | |
| CN109010701A (en) | A kind of preparation process and Chinese medicinal capsule of Chinese medicinal capsule | |
| CN106106945A (en) | A kind of Ganoderma bagged infusion of American ginseng tea of enhancing immunity and preparation method thereof | |
| CN109010558A (en) | A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue | |
| CN1370464A (en) | Vital energy and blood balancing health beverage | |
| CN101274015A (en) | Compound formulation of capsules for curing asthma and preparing technique | |
| CN106729160A (en) | A kind of health food granule of strengthen immunity and preparation method thereof | |
| CN102949529A (en) | Preparation method of liver-benefiting and detoxifying tea | |
| CN108186968B (en) | Wenweishu capsule | |
| CN104367858A (en) | Preparation process of Xuhanting capsule (medicine for treating abnormal sweating) | |
| CN1370465A (en) | Vigor-giving health beverage | |
| CN113546049A (en) | Flexible pill medicine adhesive and flexible pill prepared by using same | |
| CN1397217A (en) | Health-care beverage containing components of fleece flower root and chuan-xiong rhizome | |
| CN1397223A (en) | Health-care beverage containing components of tuckahoe and hedgehog hydnum | |
| CN1394494A (en) | Chinese medicine composite health-care tea and its preparation method | |
| CN1253810A (en) | Medicine for curing chronic bronchitis and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190326 |
|
| WD01 | Invention patent application deemed withdrawn after publication |