CN109509511A - A kind of cardiovascular and cerebrovascular relevant parameter analysis method - Google Patents
A kind of cardiovascular and cerebrovascular relevant parameter analysis method Download PDFInfo
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Abstract
The present invention provides a kind of cardiovascular and cerebrovascular relevant parameter analysis methods, comprising the following steps: S1, the Relational database for establishing cardiovascular and cerebrovascular state tumor susceptibility gene；S2, foundation life style questionnaire survey database relevant to cardiovascular and cerebrovascular state；S3, individual cardiovascular and cerebrovascular state analysis platform is established according to the Relational database of cardiovascular and cerebrovascular state tumor susceptibility gene in S1 and S2 and cardiovascular and cerebrovascular state lifestyle data library；S4, the cardiovascular and cerebrovascular state analysis platform established according to step S3 analyze the cardiovascular and cerebrovascular relevant parameter of individual；The cardiovascular and cerebrovascular state analysis result of S5, output individual.The detection method has many advantages, such as system, comprehensive, effective.
Description
Technical field
The invention belongs to biomedicine technical fields, and in particular to a kind of cardiovascular and cerebrovascular relevant parameter analysis method.
Background technique
Cardiovascular and cerebrovascular disease is exactly that cardiovascular and cerebrovascular disease are referred to as, also referred to as " rich people's disease " " three is high
Disease ".Hyperglycemia or hyperlipidemia are also suffered from while 40%~45% suffers from hypertension in 60 years old or more the elderlys, according to the Ministry of Public Health
Statistics are shown within 2007, and 50% or so diabetes patient is associated with a variety of infirmitiess of age such as hypertension, hyperlipidemia.Heart and brain
Vascular diseases have the spy of " disease incidence is high, disability rate is high, the death rate is high, high recurrence rate, and complication is more " i.e. " more than four high one "
Point, currently, China's Patients with Cardiovascular/Cerebrovascular Diseases alreadys exceed 2.7 hundred million people, China dies of cardiovascular and cerebrovascular disease nearly 3,000,000 every year
People, account for China every year total Death causes 51%.
With the arrival of social senilization and the improvement of living standard, the disease incidence of cardiovascular and cerebrovascular disease is higher and higher,
As one of the most important reason for threatening human health.Cardiovascular and cerebrovascular disease is total to by Other Risk Factors such as nature-nurtures
With influence, the generation of cardiovascular and cerebrovascular disease and event can be reduced to a certain extent by controlling and adjust risk factor.Many years grind
Study carefully and has shown that the risk factor of affirmative includes: the risk factor that age, sex, race, family history etc. can not change, high blood
Pressure, hyperlipidemia, diabetes, heart disease, TIA, weight and bad life-form structure such as smoke, drink, lack physical sport can
The risk factor etc. of change.Risk factor 90% be it is preventable, so cardiovascular and cerebrovascular disease is preventable disease, be
It can prevent the disease that can be controlled.
In recent years, with deep and molecular biology the hair of atherosclerosis and metabolic disorder syndrome research
Exhibition, the mankind from gene, molecular level understanding risk factor and are look for regulation method.The parameters analysis method passes through base
Because detecting the risk of genetic analysis predictive disease Susceptible population, poor environment danger is determined by life style questionnaire survey
Factor is simultaneously assessed, and disease relevant organism physiological and biochemical index is acquired, and is carried out to cardiovascular and cerebrovascular disease risk comprehensive and accurate
Assessment.
The development of modern medicine promotes cardio-cerebrovascular diseases and mutually ties from routine physical examination to routine physical examination with genetic test
The transformation of conjunction.It can accurately predict that in some following period a certain or certain diseases may occur for individual by genetic test
The risk of disease can determine an instantly locating precarious position of individual by routine physical examination, in conjunction with life style usually
It is final to carry out effective prevention intervention with eating habit comprehensive analysis, reduce and evade the pathogenetic risk of disease.
At home, commercialization genetic test at present is mainly chip technology, high throughput sequencing technologies and analytical technique of mass spectrum,
It is detected including diseases predisposing gene, personalized medicine guidance detection and some speciality genetic tests, but is seldom related to human body
Genome sequencing.With the continuous development of medicine and big health industry, genetic test can slowly standardize, and severization is some
Grasping core technology includes integrator gene detection platform, genetic analysis technology and disease risks gene early warning technology, gene targeting
The professional institution (company) of lower health control technical aspect will be fast-developing.
Currently, the analysis assessment of single disease is concentrated mainly on about cardiovascular and cerebrovascular disease risk assessment and Health intervention,
The report of few complex disease polygenes multidigit point neurological susceptibility comprehensive analysis methods.Meanwhile cardiovascular and cerebrovascular disease neurological susceptibility is comprehensive
It is few to close genetic analysis further investigation, and most of lacks accuracy, systematicness and comprehensive.Therefore, it is badly in need of wanting one now
Kind of system, comprehensive, effective cardiovascular and cerebrovascular disease analysis method.
Summary of the invention
The present invention is concentrated mainly on the analysis assessment of single disease for the assessment of cardiovascular and cerebrovascular relevant risk and Health intervention,
The defect of few complex disease polygenes multidigit point neurological susceptibility comprehensive analysis methods, a kind of cardiovascular and cerebrovascular relevant parameter analysis side
Method, the analysis method have many advantages, such as system, comprehensive, effective.
In order to solve the above-mentioned technical problem, a kind of one of the technical solution that the present invention takes are as follows: cardiovascular and cerebrovascular relevant parameter
Analysis method, comprising the following steps:
S1 establishes the Relational database of cardiovascular and cerebrovascular state tumor susceptibility gene；
S2 establishes life style questionnaire survey database relevant to cardiovascular and cerebrovascular state；
S3 is according to the Relational database of cardiovascular and cerebrovascular state tumor susceptibility gene in S1 and S2 and cardiovascular and cerebrovascular state life style number
Individual cardiovascular and cerebrovascular state analysis platform is established according to library；
The cardiovascular and cerebrovascular state analysis platform that S4 is established according to step S3 divides the cardiovascular and cerebrovascular relevant parameter of individual
Analysis；
The cardiovascular and cerebrovascular state analysis result of S5 output individual.
Preferably, above-mentioned S1 step further include:
The preliminary search on the website GWAS of S 101 tumor susceptibility gene title relevant to cardiovascular and cerebrovascular state；
S102 NCBI pubmed lane database, screening go out tumor susceptibility gene relevant to Chinese's cardiovascular and cerebrovascular state；
S103 searches association analysis relevant to Chinese population as a result, determining susceptible in tumor susceptibility gene acquired in S102
Gene loci；
S104 identified susceptibility loci in the snp database verifying S 103 of NCBI；
S105 writes tumor susceptibility gene collected works, the tumor susceptibility gene collected works include gene location information, functional information, information of causing a disease,
Prompt information, research achievement.
More preferably, cardiovascular and cerebrovascular state tumor susceptibility gene described in above-mentioned S1 step include: NOS3, AGT, NR3C2, PTGIS,
MTHFR、APLNR、EPHX2、IL6、LGALS2、ACE、RP1、APOC3、FABP2、UCP1、USF1、CYBA、SELE、KCNE4、
CYP11B2、KCNE1、4q25、ABCA1、GJA5、CETP、TNF、HSPBT、MYH11、PON1、CHD5、KL、APOE、APOB、
One or more of C19orf29, TBXA2R, ADRB1, APOA5, FGB, FBN1,.
Preferably, the cardiovascular and cerebrovascular state susceptibility loci has 47, as shown in table 1 in above-mentioned S103 step.
1 cardiovascular and cerebrovascular correlation tumor susceptibility gene of table and corresponding site table
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get the preferred embodiments of the invention.
The reagents and materials used in the present invention are commercially available.
The positive effect of the present invention is that: analysis method through the invention can accurately predict individual in future
The risk of a certain or certain diseases may occur for some period, in conjunction with life style questionnaire survey and routine physical examination,
It can determine an instantly locating precarious position of individual, the final effective prevention of progress is intervened, and disease is reduced and evade
Risk.
Specific embodiment
Embodiment below is used to be provided on how to implement for those skilled in the art and using the present invention
Full disclosure and description, and these examples are not intended to the invention scope thought to inventor and limit, also non-meaning
Refer to that experiment hereafter is all experimentss being carried out and is only enforceable experiment.The reality of actual conditions is not specified in experimental example
Proved recipe method, usually according to normal condition or according to condition proposed by manufacturer, chemical reagent used is that analysis is pure in embodiment
Reagent is bought from Chinese medicines group.
Embodiment 1 analyzes cardiovascular and cerebrovascular relevant parameter
The invention discloses a kind of cardiovascular and cerebrovascular relevant parameter analysis methods, comprising the following steps:
S1 establishes the Relational database of cardiovascular and cerebrovascular correlation tumor susceptibility gene；
S2 establishes life style questionnaire survey database relevant to cardiovascular and cerebrovascular；
S3 is according to the Relational database and cardiovascular and cerebrovascular related lifestyle number of S1 tumor susceptibility gene related to cardiovascular and cerebrovascular in S2
Individual cardiovascular and cerebrovascular correlation analysis platform is established according to library；
The cardiovascular and cerebrovascular correlation analysis platform that S4 is established according to step S3 divides the cardiovascular and cerebrovascular relevant parameter of individual
Analysis；
The cardiovascular and cerebrovascular correlation analysis result of S5 output individual.
Wherein, specifically, the method and step of the S1 includes:
The preliminary search on the website GWAS of S 101 tumor susceptibility gene title relevant to cardiovascular and cerebrovascular；
S102 NCBI pubmed lane database, screening go out tumor susceptibility gene relevant to Chinese's cardiovascular and cerebrovascular；
S 103 searches association analysis relevant to Chinese population as a result, determining susceptibility loci acquired in S102；
The identified susceptibility loci in the snp database verifying S 103 of NCBI of S 104；
S 105 writes tumor susceptibility gene collected works, and the tumor susceptibility gene collected works include gene location information, functional information, cause a disease letter
Breath, prompt information, research achievement.
Association analysis related to Chinese population need to meet the following conditions in above-mentioned S103: sample is large sample, sample people
Group includes at least 200 people, and OR value is greater than 1, and 95% confidence interval does not include 1 and has significant statistical significance.
Further, the cardiovascular and cerebrovascular correlation tumor susceptibility gene include: NOS3, AGT, NR3C2, PTGIS, MTHFR,
APLNR、EPHX2、IL6、LGALS2、ACE、RP1、APOC3、FABP2、UCP1、USF1、CYBA、SELE、KCNE4、CYP11B2、
KCNE1、4q25、ABCA1、GJA5、CETP、TNF、HSPBT、MYH11、PON1、CHD5、KL、APOE、APOB、C19orf29、
TBXA2R,ADRB1,APOA5,FGB,FBN1.The cardiovascular and cerebrovascular correlation phase susceptibility loci has 47.
Relational database in above-mentioned S3 according to S1 tumor susceptibility gene related to cardiovascular and cerebrovascular in S2 is related to cardiovascular and cerebrovascular raw
Mode Database individual cardiovascular and cerebrovascular correlation analysis platform living, analysis method specific implementation is as follows on the platform:
Find that specific gravity accounting about 30% of the gene in disease generating process, life style accounting is about according to newest medical statistics
70%。
There are 38 according to the cardiovascular and cerebrovascular correlation tumor susceptibility gene counted in step S101-S104, number of sites 47, such as table 1
Shown in, whole Mutation risks amount to 94；
Influencing cardiovascular and cerebrovascular risk life style has 18 as shown in table 2, tumor susceptibility gene risk assessment and life style risks
The ratio of assessment is (30%/94): (70%/18)=1:12.
If tumor susceptibility gene risk score is denoted as X, life style risk score is denoted as Y, considers cardiovascular and cerebrovascular relevant risk
Increase with the growth at age, and (this scheme is only applicable to 30 weeks in 38 years old watershed as cardiovascular and cerebrovascular disease risk
Year old or more crowd), the actual age (one full year of life) of tested people is denoted as Z, then overall risk scoring=X+(12Y) X(Z/38).
Marking explanation: tumor susceptibility gene detection is given a mark according to institute's location point and genotype, wherein there is a state of risk to comment 1
Point, 2 state of risk comment 2 points, and no state of risk comments 0 point, and one site best result of a gene comments 2 points.Life style questionnaire tune
Looked into wherein 1 comment 1 point, and so on amount to 18 points.
Overall risk grading rule is as follows:
Overall score 0-59 minute mark is compared with low-risk, and disease risks are lower than normal population.
60-119 minute mark is ordinary risk, and disease risks are identical as normal population.
120-199 minute mark is high risk, and disease risks are higher than normal population, should pay attention to.
200 points or more are denoted as high risk, and disease risks are higher than normal population, should cause to be vigilant.
It evaluates the value-at-risk come to compare with biochemical indicator (as shown in table 3), further determines tester's
Health status and the concrete reason for analyzing morbidity provide the instruction of science for diagnosis, the conditioning of cardiovascular and cerebrovascular disease.
Table 2 influences cardiovascular and cerebrovascular risk life style table
Table 3 needs the biochemical indicator table detected
| Detection project | Detected value | Term of reference |
| Apolipoprotein A1 (APOA-1) | --- | |
| Apolipoprotein B (APOB) | --- | |
| High-density lipoprotein HDL-C | --- | |
| Low-density lipoprotein LDL-C | --- | |
| HDL-C/LDL-C | --- | |
| Lipoprotein (a) (LP (a)) | --- | |
| Total cholesterol (TCHOL) | --- | |
| Total triglycerides (TRIg) | --- | |
| Hs-CRP (hsCRP) | --- | |
| Creatine kinase (CK) | ||
| Asparatate based transferase (AST) | ||
| Creatine kinase isozyme activity (CK-MB) | ||
| Lactic dehydrogenase (LDH) | ||
| Alpha hydroxyl butyric dehydrogenase (HBDH) |
The Relational database of tumor susceptibility gene, to establish life style questionnaire survey database, Parameter analysis flat by establishing by the present invention
The modes such as platform and output parameter analysis result construct a kind of analysis method of cardiovascular and cerebrovascular disease parameter.For cardiovascular and cerebrovascular disease
The Relational database of sick tumor susceptibility gene incorporates 9 kinds of cardiovascular and cerebrovascular related diseases such as hypertension, coronary heart disease, atherosclerosis
38 tumor susceptibility genes, 47 polymorphic sites, can system, comprehensively, the onset risk of effective analysis cardiovascular and cerebrovascular disease,
To take the measure of effectively preventing to provide reliable judgment basis in time.
It should be understood that those skilled in the art can make the present invention various after having read above content of the invention
Change or modification, these equivalent forms also fall within the scope of the appended claims of the present application.
Claims (4)
1. a kind of cardiovascular and cerebrovascular relevant parameter analysis method, which comprises the following steps:
S1 establishes the Relational database of cardiovascular and cerebrovascular state tumor susceptibility gene；
S2 establishes life style questionnaire survey database relevant to cardiovascular and cerebrovascular state；
S3 is according to the Relational database of cardiovascular and cerebrovascular state tumor susceptibility gene in S1 and S2 and cardiovascular and cerebrovascular state life style number
Individual cardiovascular and cerebrovascular state analysis platform is established according to library；
The cardiovascular and cerebrovascular state analysis platform that S4 is established according to step S3 divides the cardiovascular and cerebrovascular relevant parameter of individual
Analysis；
The cardiovascular and cerebrovascular state analysis result of S5 output individual.
2. cardiovascular and cerebrovascular relevant parameter analysis method according to claim 1, which is characterized in that the method and step of the S1
Include:
S101 preliminary search on the website GWAS tumor susceptibility gene title relevant to cardiovascular and cerebrovascular state；
S102 NCBI pubmed lane database, screening go out tumor susceptibility gene relevant to Chinese's cardiovascular and cerebrovascular state；
S103 searches association analysis relevant to Chinese population as a result, determining the susceptible base in tumor susceptibility gene acquired in S102
Because of site；
S104 identified susceptibility loci in the snp database verifying S 103 of NCBI；
S105 writes tumor susceptibility gene collected works, the tumor susceptibility gene collected works include gene location information, functional information, information of causing a disease,
Prompt information, research achievement.
3. cardiovascular and cerebrovascular relevant parameter analysis method according to claim 1, which is characterized in that the cardiovascular and cerebrovascular shape
State tumor susceptibility gene include: NOS3, AGT, NR3C2, PTGIS, MTHFR, APLNR, EPHX2, IL6, LGALS2, ACE, RP1,
APOC3、FABP2、UCP1、USF1、CYBA、SELE、KCNE4、CYP11B2、KCNE1、4q25、ABCA1、GJA5、CETP、TNF、
HSPBT, MYH11, PON1, CHD5, KL, APOE, APOB, C19orf29, TBXA2R, ADRB1, APOA5, FGB, FBN1, in
It is one or more.
4. cardiovascular and cerebrovascular relevant parameter analysis method according to claim 2, which is characterized in that cardiovascular and cerebrovascular described in S103
State susceptibility loci has 47, as shown in table 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110301899A (en) * | 2019-07-01 | 2019-10-08 | 湘南学院附属医院 | A kind of cardiovascular and cerebrovascular disease information detecting system and method |
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| CN101093560A (en) * | 2006-06-19 | 2007-12-26 | 上海主健生物工程有限公司 | Service system and method by using technique of gene detection to provide active health service |
| CN102758010A (en) * | 2012-06-07 | 2012-10-31 | 中国医学科学院阜外心血管病医院 | Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination |
| CN103226667A (en) * | 2013-05-17 | 2013-07-31 | 西安时代基因健康科技有限公司 | Method for acquiring characterization parameters of hypertension and complication |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101093560A (en) * | 2006-06-19 | 2007-12-26 | 上海主健生物工程有限公司 | Service system and method by using technique of gene detection to provide active health service |
| CN102758010A (en) * | 2012-06-07 | 2012-10-31 | 中国医学科学院阜外心血管病医院 | Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination |
| CN103226667A (en) * | 2013-05-17 | 2013-07-31 | 西安时代基因健康科技有限公司 | Method for acquiring characterization parameters of hypertension and complication |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301899A (en) * | 2019-07-01 | 2019-10-08 | 湘南学院附属医院 | A kind of cardiovascular and cerebrovascular disease information detecting system and method |
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