CN109496148A - Skin whitening cosmetic composition containing glycerol monolaurate - Google Patents
Skin whitening cosmetic composition containing glycerol monolaurate Download PDFInfo
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- CN109496148A CN109496148A CN201780045569.1A CN201780045569A CN109496148A CN 109496148 A CN109496148 A CN 109496148A CN 201780045569 A CN201780045569 A CN 201780045569A CN 109496148 A CN109496148 A CN 109496148A
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- skin
- cosmetic composition
- skin whitening
- whitening cosmetic
- glycerol monolaurate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The present invention relates to the skin whitening cosmetic compositions for containing glycerol monolaurate (glyceryl laurate), it confirmed that the skin whitening cosmetic composition containing the glycerol monolaurate increases skin brightness and improves the colour of skin, so that it can be expected that glycerol monolaurate of the invention is applied flexibly the exploitation in cosmetic for skin whitening.
Description
Technical field
The present invention relates to the skin whitening cosmetic compositions for containing glycerol monolaurate (glyceryl laurate).
Background technique
Cosmetic industry has the value for meeting serious hope of the consumer to human body beauty treatment and body, and it is new to be absorbed in exploitation
Product is to meet consumer demand.In South Korea's cosmetics law Article 2, functional cosmetics are defined as " facilitating skin
The product of whitening ", " helping to improve the product of wrinkle of skin " " facilitate uniformly tanned or protect the skin from ultraviolet light wound
Harmful product ".
Recently, big to the expectation of the fair skin such as white jade as consumer is more and more interested in appearance and skin
Big to increase, cosmetic industry, which is being fallen over each other according to consumer demand (need), releases the whitening production that can improve the colour of skin
Product.
Whitening has the meaning for making skin bright bleach, and can be classified as " whitening (whitening) " for making whiteness of skin
With " the brightening (brightening) " for making skin bright.
In brief, whitening (whitening) is directed to improve the fairness of skin, substantially except through inhibition
The generation of melanin prevents skin from becoming obscure, on the other hand, eliminates the melanin generated, skin is allowed to become to clean.?
South Korea needs for the notification raw material that Korean foods drug administration is approved to be suitable for use " whitening " word in the product
Product or the new whitening raw materials of exploitation and will it is suitable for products, and can just be marked by the certification of food officina as whitening function
It can property cosmetics.Have niacinamide (niacinamide) in the whitening composition that South Korea is identified, arbutin (arbutin), mulberry tree mentions
Take object, (the Kwon H.J.et such as soluble licorice and 3- ethylascorbyl (3-ethosyascorbic acid)
Al, 2015).
This word of whitening itself, which is meant that, bleaches face, but it is understood that become change skin color pole
The end meaning, it is therefore, more real than it and consumer is allowed to think that the expression of friendly word " brightening " is increasing.
Brightening (brightening) is to instigate dark and obscure skin bright, when the whitening effect with Titanium Dioxide
It is used when fruit, can be defined as whitening effect, bright color (tone-up), improves the colour of skin.
In being identified as the ingredient for being whitening composition, ascorbic acid is difficult to stablize due to its good oxidation,
Although arbutin has splendid whitening effect, expensive and can cause skin allergy.In addition, consumer is more next to whitening
It is interested, therefore, for developing a kind of research of whitening composition excellent without skin irritatin and whitening effect day
Benefit increases.
Glycerol monolaurate (glyceryl laurate) be vegetalitas supplement emulsifier, adhesive, skin softener and
Surfactant-emulsifier, and it is known with weak sterilizing ability.It is mainly used for supplying oiliness to bath product.
Therefore, the present inventor is during studying the cosmetic composition containing glycerol monolaurate, it was demonstrated that
The composition of glycerol monolaurate of the present invention shows skin whitening effects, to be accomplished the present invention.
As the prior art, Japanese Laid-Open Patent the 2015-3888th disclose it is a kind of containing polyglyceryl fatty acid ester
Preparation for external application to skin, but for increase alkyl-resorcin Transdermal absorption polyglyceryl fatty acid ester and for of the invention
A kind of effect of the glycerol monolaurate (polyglyceryl fatty acid ester) of skin-whitening is different.In KR published patent
In No. 2011-0036683, glycerol monolaurate is disclosed as antimicrobial, is absolutely not referred to or is recorded and is of the invention
Skin whitening effects.
Summary of the invention
(solving the problems, such as)
The purpose of the present invention is to provide the skin-whitening makeups containing glycerol monolaurate (glyceryl laurate)
Product composition.
(means solved the problems, such as)
The present invention relates to contain the cosmetic material of glycerol monolaurate (glyceryl laurate) as effective component
Composition.
Based on skin whitening cosmetic composition total weight, the content of the glycerol monolaurate is 0.0005-5 weight
Measure %.
The skin whitening cosmetic composition also may include cationic phospholipid surfactant.
Based on skin whitening cosmetic composition total weight, the content of the cationic phospholipid surfactant is 0.01~
1 weight %.
The cationic phospholipid surfactant can be to increase the antibacterial activity of skin whitening cosmetic composition
And it is increased.
The cationic phospholipid surfactant can be from by cocounut oil aliphatic radical PG-Dimonium Chloride Phosphate
(Sodium Coco PG-Dimonium Chloride Phosphate), sub- oleamide propyl pg dimonium chloride phosphoric acid
Ester (Linoleamidopropyl PG-Dimonium Chloride Phosphate), cocamidopropyl propyl amide PG- dimethyl chloride
Change ammonium sodium phosphate (Cocamidopropyl PG-Dimonium Chloride Phosphate), myristamide propyl PG-
The group of alkyl dimethyl ammonium chloride phosphate (Myristamidopropyl PG-Dimonium Chloride Phosphate) composition
At least one selected in group.
The skin whitening cosmetic composition also may include from by glycerol (glycerin), hexene diol (hexylene
Glycol), butanediol (butylene glycol), propylene glycol (propylene glycol), hexylene glycol (hexanediol),
At least one selected in the group of ethohexadiol (octanediol) composition.
The skin whitening cosmetic composition can be by from cream, skin soft agent, toner, astringent, nourishing cream, eye
Frost, foundation emulsion, dry powder, essence, oil liquid, gel, toner, beautifying liquid, facial mask, facial mask skin base solution, soap, washing cream, face cleaning
At least one dosage form is selected to constitute in the group of foam and clean body agent composition.
Hereinafter, the present invention will be described in detail.
The present invention relates to contain skin whitening cosmetic composition of the glycerol monolaurate as effective component.
The whitening refers to skin whitening, including by the whitening (whitening) of whiteness of skin and by the increasing of skin bright
White (brightening).
The whitening refers to the formation for inhibiting melanin, to prevent spot from occurring, while eliminating the melanin generated,
To make clean skin.
Described brighten refer to and highlight obscure skin, bright color (tone-up) can also be defined as, improve colour of skin etc..
The glycerol monolaurate is especially to improve the effective component of skin brightness for skin whitening.
The glycerol monolaurate is the monoesters formed by glycerol (glycerin) and lauric acid (lauric acid)
(mono-ester) compound of form has C15H30O4Structural formula.
The glycerol monolaurate can according to usual way from synthesis or plant oil extract.
In the present invention, in the glycerol monolaurate, by the glycerol monolaurate of monoester form 90% or more
Purer form is named as glyceryl monolaurate (glyceryl monolaurate).
Based on skin whitening cosmetic composition total weight, the content of the glycerol monolaurate is 0.0005~5 weight
Measure %.Preferably 0.001~0.5 weight %.If the glycerol monolaurate content is less than 0.0005 weight % or exceeds 5 weights
Measure %, then skin whitening effect difference or almost without.
The skin whitening cosmetic composition also may include cationic phospholipid surfactant, to increase antibacterial activity,
The cationic phospholipid surfactant can be from by cocounut oil aliphatic radical PG-Dimonium Chloride Phosphate, sub- oleamide third
Base pg dimonium chloride phosphate, cocamidopropyl propyl amide PG-Dimonium Chloride Phosphate, myristamide propyl PG-
At least one selected in the group of alkyl dimethyl ammonium chloride phosphate composition.It preferably, is cocounut oil aliphatic radical pg dimonium chloride
Sodium phosphate, and it is without being limited thereto.
Based on skin whitening cosmetic composition total weight, the content of the cationic phospholipid surfactant is 0.01~
1 weight %.If the cationic phospholipid surface-active contents less than 0.01 weight %, skin whitening cosmetic composition
Sterilizing power is not up to standard, even if preferably exceeding 1 weight %, without too many differences and be noneconomic in terms of antibacterial activity.
The skin whitening cosmetic composition can also increase from by glycerol, hexene diol, butanediol, propylene glycol, oneself two
At least one selected in the group that alcohol, ethohexadiol form.
The glycerol, hexene diol, butanediol, propylene glycol, hexylene glycol, ethohexadiol can be used for improving glycerol monolaurate
Solubility.
If not dissolving normally in the glycerol monolaurate, the whitening effect and antibacterial of glycerol monolaurate can be reduced
Activity, therefore it is extremely important to improve solubility.
The skin whitening cosmetic composition can be fabricated to concentrate.
In the concentrate manufacturing process, the glycerol monolaurate of refractory components, which is difficult to be cleaned water, to be completely dissolved,
Therefore in order to be completely dissolved glycerol monolaurate, can increase from by glycerol, hexene diol, butanediol, propylene glycol, hexylene glycol, pungent
At least one selected in the group that glycol is constituted.
When manufacturing the concentrate, constituted from by glycerol, hexene diol, butanediol, propylene glycol, hexylene glycol, ethohexadiol
Group in at least one that selects can be used as solvent to replace purified water, can also be used in mixed way with purified water.
The glycerol, hexene diol, butanediol, propylene glycol, hexylene glycol, ethohexadiol are used as solvent to replace purified water system
The skin whitening cosmetic composition made does not stimulate skin.
The concentrate can be diluted in purified water use when in use.
The dilution is that 1 times to 1000 times can be diluted on the basis of dilution total amount, this depends on the judgement of technical staff.
The skin whitening cosmetic composition further includes that additive is fabricated.
The additive can be moisturizer (moisturizer), functional raw material, thickener (thickener), softness
Agent, emulsifier (emulsifier), surfactant and pH adjusting agent etc..
The moisturizer can be glycerol, propylene glycol, butanediol, pentanediol, propylene glycol, dipropylene glycol, hyaluronic acid
(hyaluronic acid) and ceramide (ceramide) ingredient etc., but not limited to this.
The thickener can be polymer, xanthan gum, guar gum, but not limited to this.
The softening agent can be mineral oil, shea butter (shea butter), paraffin, but not limited to this.
The emulsifier can be dimethyl silicone polymer, beeswax etc.
The skin whitening cosmetic composition can be used in mixed way with whitening raw materials.
The whitening raw materials can be mulberry extract, arbutin (arbutin), ethylascorbyl ether (ethyl
Ascorbyl ether), oil soluble licorice extract, L-Ascorbic acid glucoside (ascorbyl glucoside), niacin acyl
Amine (niacinamide), α-bisabolol (α-bisabolol) and Ascorbyl Tetraisopalmitate (ascorbyl
Tetraisopalmitate), but not limited to this.
The cosmetic composition can be by cream, skin soft agent, toner, astringent, nourishing cream, eye cream, foundation emulsion, dry
Powder, essence, oil liquid, gel, toner, beautifying liquid, facial mask, facial mask skin base solution, soap, washing cream, face cleaning foam and body are clear
Clean dose of composition, but not limited to this.
The facial mask can be patch facial mask, the sheet material of the patch for the facial mask can be used from by cotton, artificial silk,
Cellulose, viscose rayon yarn, nylon, polypropylene, terylene, tencel, acrylic resin, vinylon, casein (casein) glass
At least one fiber selected in the group that fiber, paper pulp, hydrogel and cellulose are constituted.
When manufacturing the patch type facial mask, the saturation capacity for the composition being immersed in the sheet material can be 20g extremely
40g。
(The effect of invention)
The present invention relates to the cosmetic material compositions for containing glycerol monolaurate (glyceryl laurate), using containing
Having the skin brightness at the position of the facial mask of the skin whitening cosmetic composition comprising glycerol monolaurate to increase improves the colour of skin, into
And confirm skin whitening effects.
By this, it can be expected that using glycerol monolaurate of the invention, the outstanding skin-whitening makeup of exploitation whitening effect
Product composition.
Detailed description of the invention
Fig. 1 is the confirmation result for showing the skin brightness increase effect of skin whitening cosmetic composition of the invention.
Fig. 2 is the knot for showing skin whitening cosmetic composition of the invention and confirming skin brightness variation as time goes by
Fruit.
Specific embodiment
Hereinafter, will be explained in the preferred embodiment of the present invention.But the present invention is not limited to embodiment described herein,
It can be realized by other forms.On the contrary, the purpose is to sufficiently convey the principle of the invention to those skilled in the art, and make to be situated between herein
The content to continue is more thoroughly and complete.
(embodiment 1 manufactures skin whitening cosmetic composition)
The purified water that the substance of the ingredient for belonging to the following table 1 and content is placed through ion exchange resin is mixed,
To manufacture skin whitening cosmetic composition.
(table 1)
In addition, the case where glycerol monolaurate of the invention, according to material safety data, it is a kind of not soluble in water
Refractory components.Therefore, in order to improve the solubility of glycerol monolaurate, glycol (glycol) class is added, manufactures the skin of the following table 2
Skin whitening cosmetic compound.
(table 2)
(comparative example 1 manufactures the skin whitening cosmetic composition of comparison other)
By the substance of the ingredient for belonging to the following table 3 and table 4 and content be placed through the purified water of ion exchange resin into
Row mixing, has manufactured the skin whitening cosmetic composition of comparison other.
(table 3)
(table 4)
(experimental example 1 confirms the solubility of skin whitening cosmetic composition)
When manufacturing cosmetic composition, the constituent of cosmetics is not completely dissolved, therefore in the case where precipitation, is made
When for skin, skin absorptance is reduced.Therefore, it is difficult to expect the sufficient active effect by each constituent, and smear
In the case where skin, rejection feeling can be felt.Therefore, when manufacturing cosmetic composition, the solubility of each ingredient is non-
It is often important.
It detects by an unaided eye, confirms after manufacturing the skin whitening cosmetic composition of the embodiment 1 and comparative example 1
Whether the transparency of composition is precipitated with sediment, to confirm the solubility of composition, and will be as the result is shown in table 5.
(table 5)
As shown in the table 5, the case where the skin whitening cosmetic composition of this hair embodiment 1, in addition to embodiment 1-45
Remaining embodiment 1 skin whitening cosmetic composition after being made, each ingredient is all dissolved and bleach are not given birth to
At precipitate.
The case where skin whitening cosmetic composition of comparison other, observes comparative example 1-3,1-9,1-10,1-12,1-
14,2-1 and 2-2 is not completely dissolved glycerol monolaurate or glyceryl monolaurate, therefore becomes opaque, later with
There is precipitate precipitating in the process of time.
In more detail, cosmetics of the content of glycerol monolaurate or glyceryl monolaurate more than 1 weight %
In composition, using purified water as the embodiment 1-45 of solvent, comparative example 1-3,1-9,1-10,1-12,1-14,2-1 and
The case where 2-2, glycerol monolaurate or glyceryl monolaurate are not completely dissolved, become opaque, later with the time
By there is precipitate precipitating.On the contrary, the content comprising glycerol monolaurate or glyceryl monolaurate is more than 1 weight %
Cosmetic composition in using glycols (glycol) as the cosmetic combinations of the embodiment 2-1 of solvent to embodiment 2-16
The case where object, confirms glycerol monolaurate or glyceryl monolaurate and is not precipitated by solvent all and bleach.
At this point, not mixing glycols and purified water, but using glycols itself as solvent the glycols the case where
Situation, also observed the dissolution of glycerol monolaurate or glyceryl monolaurate, and confirmed not stimulate skin.
Therefore, it is known that include the cosmetic combinations of glycerol monolaurate or glyceryl monolaurate of the invention in manufacture
When object, skin is not stimulated, and can be used for improving the solubility of glycerol monolaurate or glyceryl monolaurate.
(experimental example 2 confirms the whitening effect of skin whitening cosmetic composition)
Experimental example 2-1 manufactures facial mask
The skin whitening cosmetic composition of the embodiment 1 and comparative example 1 is impregnated in, facial mask is constituted by artificial silk
Sheet material manufactures facial mask.
Experimental example 2-1 confirms the whitening effect of skin whitening cosmetic composition
In order to confirm the embodiment 1 and comparative example 1 skin whitening cosmetic composition whitening effect, it is thus identified that
Skin brightening degree, i.e. skin brightness improve degree.
It is to be measured using Konica Minolta (Konica miolita) in above-mentioned experimental example 2-1 that skin brightness, which improves degree,
The skin brightness forward and backward using facial mask of manufacture, and the forward and backward skin brightness of using face facial mask is calculated using following mathematical expression 1
Increment rate.
(mathematical expression 1)
Skin brightness increment rate=((facial mask uses preceding skin brightness using rear skin brightness/facial mask) × 100) -100
The brightness of the arm skin of measurement experiment personnel before the facial mask using dipping skin whitening cosmetic composition,
Then remove after pasting 15 minutes facial masks.After removing facial mask immediately, 5 minutes, 10 minutes, 15 minutes, measure after 20 minutes
Arm skin brightness relatively and evaluates brightness improvement, and will be as the result is shown in Fig. 1 and Fig. 2.In addition, removing facial mask
Table 6 is shown in by the skin brightness increment rate after 10 minutes later.At this point, be used in market sale have whitening function
Facial mask (ingredient: niacinamide (the niacinamide)) product of energy will use the facial mask of dipping purified water to make as positive controls
For negative control group, if skin brightness increment rate is higher than positive controls, judgement has whitening effect.
(table 6)
As shown in Figure 1, skin whitening cosmetic composition (embodiment 1-1, embodiment 1-9, embodiment 2- of the invention
10) compared to negative control group, positive controls and comparative example 1-19, it is thus identified that skin brightness significantly increases.
In addition, as shown in Fig. 2, confirming skin with time going by after removing the facial mask during pasting the predetermined time
Brightness measures at once after as a result removing facial mask, it is found that the skin brightness of positive controls increases at most, but as time goes by
The skin brightness increment rate of positive controls gradually decreases, but impregnates cosmetic for skin whitening combination of the invention in contrast
The case where facial mask of object (embodiment 1-2, embodiment 1-5, embodiment 1-9), skin brightness increment rate is gradually increased, and is removing face
Highest increment rate is embodied when 10 minutes after film, increment rate reduces later.But in the skin-whitening of dipping comparison other
The case where facial mask of cosmetic compositions (comparative example 1-4, comparative example 1-16) and purified water (negative control group), confirm skin
The reduction or similar with the skin brightness before veneer film of brightness increment rate.
In addition, as shown in table 6, be applicable in the facial mask of dipping skin whitening cosmetic composition of the invention as a result, can be with
Know compared to the present just in the whitening function facial mask of commercial type of positive controls is used as, improves skin brightness and increase
Rate, and maximum increases to 4 times.On the contrary, as the glycerol of effective component in the skin whitening cosmetic composition of comparison other
Laurate content exceeds skin whitening cosmetic composition of the invention, and by the cosmetic for skin whitening of the comparison other
In the case that composition is impregnated in facial mask, distinguishes less, but be below with skin brightness increment rate later before using facial mask
Positive controls.Accordingly, in the case of low for glycerol monolaurate content, prediction is because can embody skin brightness increases effect
The content of fruit is insufficient,, also not up to can in the case where glycerol monolaurate is precipitated even if glycerol monolaurate content is high
The content of skin whitening effects is embodied, therefore does not have skin whitening effects.In this regard, the embodiment 1-45 of the table 6 can be passed through
It is known that with embodiment 2-14.Two kinds of skin whitening cosmetic compositions of embodiment 1-45 and embodiment 2-14 all include 1
The glycerol monolaurate of weight %, but the solvent in dissolution glycerol monolaurate is different, it can therefore be appreciated that in skin brightness
Compared to embodiment 1-45 in terms of increment rate, the skin brightness increment rate of embodiment 2-14 is higher.This is because glycerol lauric acid
The case where solubility of ester is reduced and is precipitated (reference, the table 5 whether precipitation) under, prediction is not up to skin whitening effects
Content, therefore effect reduce.
Moreover embodiment 2-1 to embodiment 2-16 and is compared in skin whitening cosmetic composition of the invention
Example 2-1 to comparative example 2-25 is diluting 100 times by the purified water of ion exchange resin, impregnates facial mask later and has manufactured facial mask,
Then compare and evaluate the skin brightness improvement of these facial masks, and will be as the result is shown in table 7.
(table 7)
Shown in table 7 as shown, in skin whitening cosmetic composition of the invention, embodiment 2-1 to embodiment 2-16
100 times are being diluted by the purified water of ion exchange resin, using embodiment 2-1 to embodiment 2-16,
It confirms and more improves skin brightness than positive controls.In addition, the case where comparative example 2-25, confirm if using stoste
Skin brightness increment rate is lower than positive controls, but higher if diluting the skin brightness increment rate if.In this regard, prediction be because
For include by dilute have significant skin whitening effects proper range in glycerol monolaurate content.
Accordingly, it is known that the cosmetic for skin whitening comprising glycerol monolaurate as effective component of the invention combines
The skin brightness improvement of object is very outstanding, and these effects are by the content of glycerol monolaurate and the shadow of solubility
It rings.
(experimental example 3 confirms the antibacterial effect of skin whitening cosmetic composition)
The skin improvement effects of cosmetics are not only in cosmetic product, antibacterial activity degree also functions to very important work
With, therefore the case where cosmetic product, it also include antibacterial agent.Accordingly, confirm the skin of the embodiment 1 and comparative example 1
The antibacterial activity of whitening cosmetic compound.
The antibacterial activity test is executed according to the benchmark of U.S.'s cosmetics Industry Association (CTFA).Specifically, being
The reduction and the death rate of confirmation bacterium, are tested by plating method, and bacterium is divided into bacterium and fungi confirmation antibacterial is living
Property.Bacterium utilizes by yellow staphylococcus pyogenes (Staphylococcus aureus), Escherichia coli (Escherichia
Coli), the bacterium that pseudomonas aeruginosa (Pseudomonas aerugin osa) mixes, fungi utilize by Brazil's aspergillus
The bacterium that (Aspergillus brasiliensis), candida albicans (Candida albicans) mix.
The skin whitening cosmetic composition is inoculated with bacterium (bacterium 106CFU/ml；Fungi 105CFU/ml) pass through 72 hours
Later, it is coated on plating medium, is cultivated 72 hours at 30~35 DEG C.At this point, embodiment 1-1 to embodiment 1-46 and ratio
Cosmetic composition itself, embodiment 2-1 to embodiment 2-16 and comparative example 2- are directly used compared with example 1-1 to comparative example 1-25
1 to comparative example 2-25 cosmetic composition uses after diluting 100 times by ion exchange resin purified water, and control group makes
With the bacterium mixed liquor of untreated skin whitening cosmetic composition.After cultivating each bacterium, count raw in plating medium
At bacterium bacterium colony (colony) quantity, the death rate of bacterium is calculated using following mathematical expression 2 later, and will be as the result is shown in table 8.
(mathematical expression 2)
The death rate of bacterium=(the inoculation bacterium number of (inoculation bacterium number amount-composition residual bacterium number amount of control group)/control group
Amount) X100
The death rate benchmark of bacterium for cosmetic composition is 99.9% or more, therefore, the case where less than 99.9% not
Suitable for cosmetic composition.
(table 8)
As shown in Table 8 above, such as embodiment 1-1, embodiment 1- in skin whitening cosmetic composition of the invention
2, embodiment 1-4 and embodiment 1-5 is separately including the glycerol monolaurate of 0.001 weight % or 0.02 weight %
Situation is not up to the death rate standard for being used as the bacterium of cosmetic composition to the antibacterial activity of fungi and bacterium, but such as
The case where embodiment 1-3 and embodiment 1-6 includes the glycerol monolaurate of 0.5 weight %, confirms antibacterial activity and exists
99.99% or more.
On the contrary, the skin whitening cosmetic composition of the embodiment 1-45 of the glycerol monolaurate comprising 1 weight %
Situation confirms the standard for being not up to the antibacterial activity of bacterium and fungi and being used as the bacterium death rate of cosmetic composition, right
This prediction is that the glycerol monolaurate of 1 weight % is not well dissolved in purified water, therefore influences antibacterial activity.
It further says, the cosmetic composition of such as embodiment 1-1 to embodiment 1-6, is only including glycerol lauric acid
The cosmetic composition of ester or glyceryl monolaurate increases the embodiment 1-7 of cationic phospholipid surfactant to embodiment
The case where skin whitening cosmetic composition of 1-44 and embodiment 1-46, confirms antibacterial activity 99.9% or more.But
It is, if antibacterial activity is not up to 99.9%, i.e., in the case where cationic phospholipid surfactant of the addition less than 0.01 weight %
Make also to confirm antibacterial activity also without too big difference more than 1%.
Accordingly, the case where the skin whitening cosmetic composition of the invention containing glycerol monolaurate, not only there is beauty
White effect also while having an antibacterial activity, it can therefore be appreciated that can not only flexible utilization in skin-lightening cosmetic product, additionally it is possible to
Reduce the usage amount of the antimicrobial added to save cosmetic product.
Claims (8)
1. a kind of skin whitening cosmetic composition, which is characterized in that comprising glycerol monolaurate as effective component.
2. skin whitening cosmetic composition according to claim 1, which is characterized in that
Based on composition total weight, the content of the glycerol monolaurate is 0.0005-5 weight %.
3. skin whitening cosmetic composition according to claim 1 or 2, which is characterized in that
The composition also includes cationic phospholipid surfactant.
4. skin whitening cosmetic composition according to claim 3, which is characterized in that
Based on composition total weight, the cationic phospholipid surface-active content is 0.01~1 weight %.
5. skin whitening cosmetic composition according to claim 3, which is characterized in that
The cationic phospholipid surfactant is increased in order to increase antibacterial activity.
6. skin whitening cosmetic composition according to claim 3, which is characterized in that
The cationic phospholipid surfactant includes from by cocounut oil aliphatic radical PG-Dimonium Chloride Phosphate, sub- oleamide
Propyl pg dimonium chloride phosphate, cocamidopropyl propyl amide PG-Dimonium Chloride Phosphate, myristamide propyl
At least one selected in the group of pg dimonium chloride phosphate composition.
7. skin whitening cosmetic composition according to claim 1 or 2, which is characterized in that
The composition also includes from the group being made of glycerol, hexene diol, butanediol, propylene glycol, hexylene glycol, ethohexadiol
At least one of selection.
8. skin whitening cosmetic composition according to claim 1 or 2, which is characterized in that
The cosmetic composition by from cream, skin soft agent, toner, astringent, nourishing cream, eye cream, foundation emulsion, dry powder,
Essence, oil liquid, gel, toner, beautifying liquid, facial mask, facial mask skin base solution, soap, washing cream, face cleaning foam and clean body agent
At least one dosage form is selected to constitute in the group of composition.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160159144 | 2016-11-28 | ||
| KR10-2016-0159144 | 2016-11-28 | ||
| KR10-2017-0058638 | 2017-05-11 | ||
| KR1020170058638A KR101824424B1 (en) | 2016-11-28 | 2017-05-11 | Cosmetic composition comprising glyceryl laurate for skin whitening |
| PCT/KR2017/013703 WO2018097698A1 (en) | 2016-11-28 | 2017-11-28 | Skin-whitening cosmetic composition comprising glyceryl laurate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109496148A true CN109496148A (en) | 2019-03-19 |
| CN109496148B CN109496148B (en) | 2021-09-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780045569.1A Active CN109496148B (en) | 2016-11-28 | 2017-11-28 | Skin whitening cosmetic composition containing glyceryl laurate |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2019525959A (en) |
| KR (1) | KR101824424B1 (en) |
| CN (1) | CN109496148B (en) |
| WO (1) | WO2018097698A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102026364B1 (en) | 2018-05-11 | 2019-11-04 | 주식회사 네이처인랩 | Flower bud extraction composition and method for preparing the same |
| CN110623853B (en) * | 2019-07-29 | 2022-09-09 | 德亚生物科技有限公司 | Cleaning and nursing composition and preparation method thereof |
Citations (8)
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|---|---|---|---|---|
| JP2004026657A (en) * | 2002-06-21 | 2004-01-29 | Pola Chem Ind Inc | Cosmetic for bleaching |
| JP2004331592A (en) * | 2003-05-08 | 2004-11-25 | National Institute Of Advanced Industrial & Technology | Skin care preparation for external use, soap, bathing agent, fiber-treating agent, and fiber each, containing bleaching agent compounded therewith |
| JP2007056009A (en) * | 2005-07-27 | 2007-03-08 | Showa Denko Kk | Emulsified external preparation for skin and method for stabilizing the external preparation for skin |
| JP2007063140A (en) * | 2005-08-29 | 2007-03-15 | Nikko Chemical Co Ltd | Bleaching agent and bleaching cosmetic containing the same |
| WO2007091694A1 (en) * | 2006-02-06 | 2007-08-16 | Showa Denko K.K. | Whitening dermatological preparations |
| CN103705391A (en) * | 2013-12-16 | 2014-04-09 | 浙江赞宇科技股份有限公司 | Gentle face wash capable of naturally removing acne marks and blackheads and whitening and rejuvenating skins and preparation method thereof |
| CN104940118A (en) * | 2015-06-20 | 2015-09-30 | 青岛克立克信息技术有限公司 | Anti-freckle night cream |
| JP2016150900A (en) * | 2015-02-16 | 2016-08-22 | アサヒフードアンドヘルスケア株式会社 | Skin external preparation for inhibiting melanogenesis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6180816B2 (en) | 2013-06-24 | 2017-08-16 | ポーラ化成工業株式会社 | Topical skin preparation |
-
2017
- 2017-05-11 KR KR1020170058638A patent/KR101824424B1/en active IP Right Grant
- 2017-11-28 JP JP2019524107A patent/JP2019525959A/en active Pending
- 2017-11-28 CN CN201780045569.1A patent/CN109496148B/en active Active
- 2017-11-28 WO PCT/KR2017/013703 patent/WO2018097698A1/en active Application Filing
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| JP2004026657A (en) * | 2002-06-21 | 2004-01-29 | Pola Chem Ind Inc | Cosmetic for bleaching |
| JP2004331592A (en) * | 2003-05-08 | 2004-11-25 | National Institute Of Advanced Industrial & Technology | Skin care preparation for external use, soap, bathing agent, fiber-treating agent, and fiber each, containing bleaching agent compounded therewith |
| JP2007056009A (en) * | 2005-07-27 | 2007-03-08 | Showa Denko Kk | Emulsified external preparation for skin and method for stabilizing the external preparation for skin |
| JP2007063140A (en) * | 2005-08-29 | 2007-03-15 | Nikko Chemical Co Ltd | Bleaching agent and bleaching cosmetic containing the same |
| WO2007091694A1 (en) * | 2006-02-06 | 2007-08-16 | Showa Denko K.K. | Whitening dermatological preparations |
| CN103705391A (en) * | 2013-12-16 | 2014-04-09 | 浙江赞宇科技股份有限公司 | Gentle face wash capable of naturally removing acne marks and blackheads and whitening and rejuvenating skins and preparation method thereof |
| JP2016150900A (en) * | 2015-02-16 | 2016-08-22 | アサヒフードアンドヘルスケア株式会社 | Skin external preparation for inhibiting melanogenesis |
| CN104940118A (en) * | 2015-06-20 | 2015-09-30 | 青岛克立克信息技术有限公司 | Anti-freckle night cream |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN109496148B (en) | 2021-09-17 |
| KR101824424B1 (en) | 2018-02-01 |
| WO2018097698A1 (en) | 2018-05-31 |
| JP2019525959A (en) | 2019-09-12 |
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