CN109493942A - A kind of drug abortion method for canine - Google Patents
A kind of drug abortion method for canine Download PDFInfo
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Abstract
The invention discloses a kind of drug abortion methods for canine, including drug screening, the determination of the optimal termination of pregnancy drug of canine, the optimal termination of pregnancy drug effect efficiency of canine and pregnant time relationship assessment, the optimal termination of pregnancy drug safe dose assessment of canine and five steps of public place clinical test, this method covers the screening of canine gestation drug, the canine drug abortion implementation steps of the complete sets such as drug safety assessment and public place dispensing, under the premise of ensure that canine life and health, propose the putting mode of drug, and this method is easy to operate, it is low in cost, convenient in public place application implementation, new way is provided for the regulating and controlling of quantities of wandering dog only.
Description
Technical field
The present invention relates to medical sanitary technology fields, and in particular to a kind of drug abortion method for canine.
Background technique
As the improvement of people's living standards, more and more families raise pet dog.On the one hand since people are not responsible
Canine abandonment and the unordered breeding of wandering dog caused by the raising behavior appointed, so that the dog of city wandering in recent years constantly increases
It is more, become a quite serious social concern.Since the living environment of wandering dog is severe, cannot periodically be immunized, expelling parasite,
Disinfection carries virus, bacterium and the probability of helminth and is significantly larger than domestic dog.Wandering dog also often attacks other animals even people
Class, there are sizable security risk, excreta also will affect urban health, if do not dealt carefully with, corpse after death
Can rot smelly pollution environment, the transmission thus caused, maltreat slaughter, public safety etc. the problem of it is just increasingly tight
Weight.
How to carry out Effective Regulation to the reproductive behavior of wandering dog is that one quite intractable but that is not taken seriously asks
Topic, each place domestic at present are exactly to do sterilization operation to dog, but current status is the exhausted of wandering dog by the way of more
Educating operation can not be widely popularized.On the one hand its reason is that the capture difficulty of wandering dog is larger, another aspect canine sterilization
Cost of performing the operation is also higher, and there are certain risks, danger are especially easy to happen in sterilization operation anaesthesia process, after surgery
It is easy infection, or even jeopardizes the life of canine.
Summary of the invention
It is an object of the present invention to overcome defect existing in the prior art, a kind of drug abortion for canine is provided
Method covers the canine medicine of the complete sets such as the screening, drug safety assessment and public place dispensing of canine gestation drug
Logistics produces implementation steps, under the premise of ensure that canine life and health, proposes the putting mode of drug, and this method operates
Simply, low in cost, convenient for providing new way for the regulating and controlling of quantities of wandering dog only in public place application implementation.
To achieve the above object, the technical scheme is to design a kind of drug abortion methods for canine, including
Following steps:
S1: drug screening filters out the common animal pregnancy of N kind and terminates drug as canine laboratory clinical termination of pregnancy
Trial drug；
S2: the determination of the optimal termination of pregnancy drug of canine, by the test all the same of certain amount aspectual character, pregnant time
Dog is divided into the N+1 group that every group of quantity is equal, wherein one group is control group, other N groups are experimental group, by the N kind in step S1
Drug allows the test dog correspondence of N group experimental group to be taken respectively, and the drug dose and the body of the test dog that every test dog takes
The ratio between weight is equal, and the embryo for recording experimental group and control group test dog respectively originates total amount, normal fetus quantity and miscarriage quantity,
And every group of abortion ratio is calculated, obtain the optimal termination of pregnancy drug suitable for canine；
S3: the optimal termination of pregnancy drug effect efficiency of canine and pregnant time relationship assessment, by certain amount aspectual character
Identical test dog is successively divided into the several groups that every group of quantity is equal according to pregnant time, and every test dog is allowed to take one respectively
Determine the optimal termination of pregnancy drug suitable for canine that dose step S2 is obtained, and every is tested the drug dose and be somebody's turn to do that dog takes
The ratio between weight of test dog is equal, and the embryo for recording every group of test dog respectively originates total amount, normal fetus quantity and miscarriage quantity,
And every group of abortion ratio is calculated, obtain the relationship between the optimal termination of pregnancy drug effect efficiency of canine and pregnant time；
S4: the optimal termination of pregnancy drug safe dose assessment of canine, certain amount aspectual character, pregnant time is all the same
Test dog be divided into the several groups that every group of quantity is equal, allow the test dog of each experimental group to take drugs dosage and weight respectively
The ratio between the optimal termination of pregnancy drug suitable for canine that obtains of different step S2, and the test dog in same experimental group takes
Drug dose it is equal with the ratio between the weight of the test dog, record the test of physical signs abnormal parameters in each experimental group respectively
Dog quantity obtains the effective dosage and maximum safe dose of optimal termination of pregnancy drug；
S5: public place clinical test, according to the maximum safe dose of the step S4 optimal termination of pregnancy drug obtained and
The average daily feed intake of every dog, the optimal termination of pregnancy drug that step S2 is obtained mix according to a certain percentage with dog grain
Uniformly, and bait is made, bait is subjected to feeding, monitoring wandering dog gestation farrowing situation in public place for wandering dog.
This method drug screening is carried out on the basis of currently used animal pregnancy terminates drug, that is, be ensure that and faced
Drug safety used is tested in bed termination of pregnancy；This method give the determination method of the optimal termination of pregnancy drug of canine, comment
Estimated relationship between the optimal termination of pregnancy drug effect efficiency of canine and pregnant time, optimal termination of pregnancy drug effectively to
Pharmaceutical quantities and maximum safener method for determination of amount and public place is given under the premise of guaranteeing canine life and health face
Bed test method, that is, ensure that the feasibility that this method is implemented from clinical trial to the public, mention for the regulating and controlling of quantities of wandering dog only
New way is supplied.
In order to guarantee the efficiency of the practice of this method, preferred technical solution is the canine reality filtered out in the step S1
Testing room clinical pregnancy termination test drug is mifepristone, stilbestrol, long-acting 15-methyl-prostaglandin F2a methylate and Aglepristone.
In order to study the action effective of the optimal termination of pregnancy drug of canine, preferred technical solution is the step S2
The pregnant time of the test dog of middle selection is 20~25 days, and step S2 further includes taking clinical pregnancy from test dog to terminate drug
It rises, each experimental group and the control group test average blood plasma progesterone content of dog, normal fetus quantity and different was detected every 3~7 days
Normal embryo's quantity.
In order to guarantee the practical of the inventive method, guarantee effective efficiency of the practice of the method for the present invention, further preferably
Technical solution in addition, the optimal termination of pregnancy drug suitable for canine obtained in the step S2 be Aglepristone, it is described
Step S4 obtain Aglepristone effective dosage be per kilogram of body weight >=10mg, maximum safe dose be per kilogram of body weight≤
100mg。
It is further excellent in order to which the clear research optimal termination of pregnancy drug of canine is to the functioning efficiency of different gestational age embryos
The technical solution of choosing is in addition, further include from test dog takes clinical pregnancy termination drug, every 3~7 days in the step S3
Detect the normal fetus quantity and abnormal embryo's quantity of every group of test dog.
The optimal termination of pregnancy drug of canine in order to study various dose is to the influence situation of canine parent health, for the medicine
Object public place launch when ensure canine parent health provide data support, further preferred technical solution in addition,
In the step S4 physical signs parameter include body temperature, breathing situation, heart rate, blood pressure, electrocardiogram, blood routine, vim and vigour, liver function,
Kidney function and reproductive system are impaired.
In order under the premise of guaranteeing that canine parent is healthy, by the optimal termination of pregnancy drug of the canine in the suitable of public place
Benefit is implemented, further preferred technical solution in addition, the step S5 concrete operation step be by Aglepristone and dog grain according to
The ratio of 1:4000 is uniformly mixed, and bait is made, and monitors the amount of activity of public place wandering dog, estimates the totality of wandering dog
Weight launches bait with the ratio of per kilogram of body weight 40g, and launches a bait daily, and wandering dog is allowed to be freely eaten, and by bait
Continuous to launch one week, being then spaced two weeks, persistently dispensing bait one week, circulation are launched bait half a year again, monitoring wandering dog hair
Feelings breeding and gestation farrowing situation, and random catching certain amount wandering dog checks pregnant state.
The advantages and beneficial effects of the present invention are:
1, this method drug screening is carried out on the basis of currently used animal pregnancy terminates drug, that is, ensure that
Drug safety used in clinical pregnancy termination test；This method give the determination method of the optimal termination of pregnancy drug of canine,
Have evaluated relationship between the optimal termination of pregnancy drug effect efficiency of canine and pregnant time, optimal termination of pregnancy drug it is effective
Dosage and maximum safener method for determination of amount and public place is given under the premise of guaranteeing canine life and health
Clinical testing procedure ensure that the feasibility that this method is implemented from clinical trial to the public, be the regulating and controlling of quantities of wandering dog only
Provide new way.
2, the canine laboratory clinical termination of pregnancy trial drug filtered out in step S1 be mifepristone, stilbestrol,
Long-acting 15-methyl-prostaglandin F2a methylate and Aglepristone ensure that the efficiency of the practice of this method.
3, the pregnant time for the test dog selected in step S2 is 20~25 days, and step S2 further includes taking to face from test dog
Bed termination of pregnancy drug rises, and the average blood plasma progesterone content, just of each experimental group and control group test dog was detected every 3~7 days
Normal embryo's quantity and abnormal embryo's quantity, have studied the action effective of the optimal termination of pregnancy drug of canine.
4, the optimal termination of pregnancy drug suitable for canine obtained in step S2 is Aglepristone, and the step S4 is obtained
Effective dosage of Aglepristone is per kilogram of body weight >=10mg, and maximum safe dose is per kilogram of body weight≤100mg, is guaranteed
Effective efficiency of the practice of practical and the method for the present invention of the inventive method.
It 5, further include that every group of test was detected every 3~7 days from test dog takes clinical pregnancy termination drug in step S3
The normal fetus quantity of dog and abnormal embryo's quantity, clearly have studied the optimal termination of pregnancy drug of canine to different gestational age embryos
The functioning efficiency of tire.
6, in step S4 physical signs parameter include body temperature, breathing situation, heart rate, blood pressure, electrocardiogram, blood routine, vim and vigour,
Liver function, kidney function and reproductive system are impaired, have studied the optimal termination of pregnancy drug of canine of various dose to canine parent health
Situation is influenced, ensures that canine parent health provides data and supports when public place is launched for the drug.
Specific embodiment
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more
Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
The present invention is a kind of drug abortion method for canine, is included the following steps:
S1: drug screening filters out the common animal pregnancy of N kind and terminates drug as canine laboratory clinical termination of pregnancy
Trial drug；
S2: the determination of the optimal termination of pregnancy drug of canine, by the test all the same of certain amount aspectual character, pregnant time
Dog is divided into the N+1 group that every group of quantity is equal, wherein one group is control group, other N groups are experimental group, by the N kind in step S1
Drug allows the test dog correspondence of N group experimental group to be taken respectively, and the drug dose and the body of the test dog that every test dog takes
The ratio between weight is equal, and the embryo for recording experimental group and control group test dog respectively originates total amount, normal fetus quantity and miscarriage quantity,
And every group of abortion ratio is calculated, obtain the optimal termination of pregnancy drug suitable for canine；
S3: the optimal termination of pregnancy drug effect efficiency of canine and pregnant time relationship assessment, by certain amount aspectual character
Identical test dog is successively divided into the several groups that every group of quantity is equal according to pregnant time, and every test dog is allowed to take one respectively
Determine the optimal termination of pregnancy drug suitable for canine that dose step S2 is obtained, and every is tested the drug dose and be somebody's turn to do that dog takes
The ratio between weight of test dog is equal, and the embryo for recording every group of test dog respectively originates total amount, normal fetus quantity and miscarriage quantity,
And every group of abortion ratio is calculated, obtain the relationship between the optimal termination of pregnancy drug effect efficiency of canine and pregnant time；
S4: the optimal termination of pregnancy drug safe dose assessment of canine, certain amount aspectual character, pregnant time is all the same
Test dog be divided into the several groups that every group of quantity is equal, allow the test dog of each experimental group to take drugs dosage and weight respectively
The ratio between the optimal termination of pregnancy drug suitable for canine that obtains of different step S2, and the test dog in same experimental group takes
Drug dose it is equal with the ratio between the weight of the test dog, record the test of physical signs abnormal parameters in each experimental group respectively
Dog quantity obtains the effective dosage and maximum safe dose of optimal termination of pregnancy drug；
S5: public place clinical test, according to the maximum safe dose of the step S4 optimal termination of pregnancy drug obtained and
The average daily feed intake of every dog, the optimal termination of pregnancy drug that step S2 is obtained mix according to a certain percentage with dog grain
Uniformly, and bait is made, bait is subjected to feeding, monitoring wandering dog gestation farrowing situation in public place for wandering dog.
In order to guarantee the efficiency of the practice of this method, preferred technical solution is the canine reality filtered out in the step S1
Testing room clinical pregnancy termination test drug is mifepristone, stilbestrol, long-acting 15-methyl-prostaglandin F2a methylate and Aglepristone.
In order to study the action effective of the optimal termination of pregnancy drug of canine, preferred technical solution is the step S2
The pregnant time of the test dog of middle selection is 20~25 days, and step S2 further includes taking clinical pregnancy from test dog to terminate drug
It rises, each experimental group and the control group test average blood plasma progesterone content of dog, normal fetus quantity and different was detected every 3~7 days
Normal embryo's quantity.
In order to guarantee the practical of the inventive method, guarantee effective efficiency of the practice of the method for the present invention, further preferably
Technical solution in addition, the optimal termination of pregnancy drug suitable for canine obtained in the step S2 be Aglepristone, it is described
Step S4 obtain Aglepristone effective dosage be per kilogram of body weight >=10mg, maximum safe dose be per kilogram of body weight≤
100mg。
It is further excellent in order to which the clear research optimal termination of pregnancy drug of canine is to the functioning efficiency of different gestational age embryos
The technical solution of choosing is in addition, further include from test dog takes clinical pregnancy termination drug, every 3~7 days in the step S3
Detect the normal fetus quantity and abnormal embryo's quantity of every group of test dog.
The optimal termination of pregnancy drug of canine in order to study various dose is to the influence situation of canine parent health, for the medicine
Object public place launch when ensure canine parent health provide data support, further preferred technical solution in addition,
In the step S4 physical signs parameter include body temperature, breathing situation, heart rate, blood pressure, electrocardiogram, blood routine, vim and vigour, liver function,
Kidney function and reproductive system are impaired.
In order under the premise of guaranteeing that canine parent is healthy, by the optimal termination of pregnancy drug of the canine in the suitable of public place
Benefit is implemented, further preferred technical solution in addition, the step S5 concrete operation step be by Aglepristone and dog grain according to
The ratio of 1:4000 is uniformly mixed, and bait is made, and monitors the amount of activity of public place wandering dog, estimates the totality of wandering dog
Weight launches bait with the ratio of per kilogram of body weight 40g, and launches a bait daily, and wandering dog is allowed to be freely eaten, and by bait
Continuous to launch one week, being then spaced two weeks, persistently dispensing bait one week, circulation are launched bait half a year again, monitoring wandering dog hair
Feelings breeding and gestation farrowing situation, and random catching certain amount wandering dog checks pregnant state.
Embodiment 1
S1: drug screening, using mifepristone, stilbestrol, four kinds of drugs of long-acting 15- first PGF2a and Aglepristone as
Canine laboratory clinical termination of pregnancy trial drug；
S2: the determination of the optimal termination of pregnancy drug of canine,
25 one-year-old left and right, the beasle dog that pregnant time is 25 days are only divided into 5 groups with every group 5, wherein 1 group is control
Group, other 4 groups are experimental group, and the test dog of 4 groups of experimental groups is respectively corresponded and takes mifepristone, stilbestrol, long-acting 15- first
The dose of four kinds of drugs of PGF2a and Aglepristone, every test dog is per kilogram of body weight 10mg, records every group of embryo respectively
It originates total amount and average plasma progesterone content, and detected for time interval every group of average blood plasma progesterone content, just respectively with 5 days
Normal embryo's quantity and abnormal embryo's quantity.
The average blood plasma progesterone content nmol/L of 1 every group of test dog of table
Analysis of experimental results: as shown in Table 1, Aglepristone group tests average blood plasma progesterone content of the dog after medication 5 days
Drop-out value (about 30nmol/L) is more obvious compared to the average blood plasma progesterone content drop-out value of other 3 experimental groups, and Ah
To take charge of ketone group test dog average blood plasma progesterone content (8.2nmol/L) and average blood plasma progesterone at medication 5 days at medication 25 days
Content (12.4nmol/L) is not much different (only 4nmol/L), illustrates that Aglepristone is used as the effect of canine termination of pregnancy drug
Efficiency is best.
The embryonic development situation of the test dog of table 2
Analysis of experimental results: as shown in Table 2, the abortion ratio that Aglepristone group tests dog is 100%, and other 3 experiments
The abortion ratio of group test dog is not up to 100%, illustrates that function and effect of the Aglepristone as canine termination of pregnancy drug are best.
Embodiment 2
S3: the optimal termination of pregnancy drug effect efficiency of canine and pregnant time relationship assessment,
7 experimental groups, every group of beasle dog for 5 one-year-old left and right, the pregnant time difference of 7 experimental group beasle dogs are set
For 30 days, 35 days, 40 days, 45 days, 50 days, 55 days, 60 days, by the test dog of 7 experimental groups respectively according to per kilogram of body weight
The amount of 10mg takes Aglepristone, records every group of embryo respectively and originates total amount and take the normal fetus after Aglepristone 25 days
Quantity and abnormal embryo's quantity.
Table 3 tests dog embryonic development situation
Analysis of experimental results: as shown in Table 3, effective termination of pregnancy range of Aglepristone is very long, from Early placental phase to end
Phase is effective.After the test dog within gestation 45 days takes Aglepristone, most embryos can be absorbed, necrosis or only
There are trace, average abortion ratio 90.5%.After gestation 45 days or more test dogs are using Aglepristone, there are a certain number of embryos
Tire normal development, partial embryonic is absorbed, downright bad or only there are trace, average abortions ratio 50.8%.
Embodiment 3
S4: the optimal termination of pregnancy drug safe dose assessment of canine,
14 experimental groups are set, every group be 5 one-year-old left and right, the beasle dog that pregnant time is 30 days, by 14 experimental groups
Test dog respectively according to per kilogram of body weight 7mg, 8mg, 9mg, 10mg, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg,
The amount of 80mg, 90mg, 100mg, 110mg take Aglepristone, physiology occur after recording every group of test dog medication respectively 1 hour and refer to
Mark the test dog quantity of abnormal parameters；For the experimental group for physical signs abnormal parameters do not occur, every group of embryo is recorded respectively
Tire starting total amount and normal fetus quantity and abnormal embryo's quantity after taking Aglepristone 25 days, and calculate abortion ratio.
Table 4 tests dog termination of pregnancy drug Aglepristone maximum safe dose test result
Table 5 tests the effective dosage test result of dog termination of pregnancy drug Aglepristone
The results showed that as shown in Table 4, the maximum safe dose of canine highest feeding Aglepristone is per kilogram of body weight
100mg；As shown in Table 5, effective dosage of Aglepristone is canine per kilogram of body weight 10mg.Experiment shows to test dog most
Ten multiple doses of height feeding effective dose, will not cause damages to the healthy and safe of dog, i.e., Aglepristone is as canine gestation
It is higher to terminate Drug safety.
Embodiment 4
S5: public place clinical test,
Aglepristone and dedicated dog grain are uniformly mixed according to the ratio of 1:4000, suitable quantity of water can be added, bait is made.It is public
Many place clinical tests are selected in some residential quarters of Yanqing, an Entertainment Plaza and an amusement park and carry out fixed point dispensing,
The amount of activity of each public place wandering dog is monitored, estimates the total weight of wandering dog, is launched with the ratio of per kilogram of body weight 40g
Bait, and a bait is launched daily, it allows wandering dog to be freely eaten, and bait is continuously launched one week, is then spaced two weeks
It persistently launches bait one week again, circulation launches bait half a year.To prevent accident, need to be arranged in each bait release position
Watchful marks such as " wandering dog bait release positions ".During test, observation wandering dog rutting and gestation farrowing situation, and it is random
It captures certain amount wandering dog and checks pregnant state.
6 public place canine termination of pregnancy clinical test results of table
The results showed that as shown in Table 6, the termination of pregnancy effect of the bait is fairly obvious, public place clinical test
Most wandering dogs in region do not farrow there is a phenomenon where unexpected pregnancy, and termination of pregnancy effective percentage reaches 85% or more, says
Drug abortion method of the bright invention for canine is practicable.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of drug abortion method for canine, which comprises the steps of:
S1: drug screening filters out the common animal pregnancy of N kind and terminates drug as canine laboratory clinical termination of pregnancy test
Drug；
S2: the determination of the optimal termination of pregnancy drug of canine, by certain amount aspectual character, pregnant time test dog all the same point
For the N+1 group that every group of quantity is equal, wherein one group is control group, other N groups are experimental group, by the N kind drug in step S1
Allow the test dog correspondence of N group experimental group to be taken respectively, and the weight of every drug dose for taking of test dog and the test dog it
Than equal, the embryo for recording experimental group and control group test dog respectively originates total amount, normal fetus quantity and miscarriage quantity, and counts
Every group of abortion ratio is calculated, obtains the optimal termination of pregnancy drug suitable for canine；
S3: the optimal termination of pregnancy drug effect efficiency of canine and pregnant time relationship assessment are identical by certain amount aspectual character
Test dog be successively divided into the several groups that every group of quantity is equal according to pregnant time, allow every test dog to take certain agent respectively
The optimal termination of pregnancy drug suitable for canine that amount step S2 is obtained, and every is tested the drug dose and the test that dog takes
The ratio between weight of dog is equal, and the embryo for recording every group of test dog respectively originates total amount, normal fetus quantity and miscarriage quantity, and counts
Every group of abortion ratio is calculated, obtains the relationship between the optimal termination of pregnancy drug effect efficiency of canine and pregnant time；
S4: the optimal termination of pregnancy drug safe dose assessment of canine, by the examination all the same of certain amount aspectual character, pregnant time
It tests dog and is divided into the several groups that every group of quantity is equal, the test dog of each experimental group is allowed to take drugs the ratio between dosage and weight respectively
The optimal termination of pregnancy drug suitable for canine that different step S2 is obtained, and the medicine that the test dog in same experimental group takes
Agent amount is equal with the ratio between the weight of the test dog, records the test dog number of physical signs abnormal parameters in each experimental group respectively
Amount obtains the effective dosage and maximum safe dose of optimal termination of pregnancy drug；
S5: public place clinical test, according to the maximum safe dose of the step S4 optimal termination of pregnancy drug obtained and every
The average daily feed intake of dog, the optimal termination of pregnancy drug that step S2 is obtained mix according to a certain percentage with dog grain
It is even, and bait is made, bait is subjected to feeding, monitoring wandering dog gestation farrowing situation in public place for wandering dog.
2. being used for the drug abortion method of canine as described in claim 1, which is characterized in that filtered out in the step S1
Canine laboratory clinical termination of pregnancy trial drug is mifepristone, stilbestrol, long-acting 15-methyl-prostaglandin F2a methylate and A Lai
Take charge of ketone.
3. being used for the drug abortion method of canine as claimed in claim 2, which is characterized in that the examination selected in the step S2
The pregnant time for testing dog is 20~25 days, and step S2 further includes from test dog takes clinical pregnancy termination drug, every 3~7
It detects the average blood plasma progesterone content of each experimental group and control group test dog, normal fetus quantity and abnormal embryo's quantity.
4. being used for the drug abortion method of canine as claimed in claim 3, which is characterized in that is obtained in the step S2 is suitable
Optimal termination of pregnancy drug for canine is Aglepristone, and the step S4 show that effective dosage of Aglepristone is every
Kg body weight >=10mg, maximum safe dose are per kilogram of body weight≤100mg.
5. being used for the drug abortion method of canine as claimed in claim 4, which is characterized in that further include certainly in the step S3
Test dog takes clinical pregnancy and terminates drug, and normal fetus quantity and the exception embryo of every group of test dog were detected every 3~7 days
Quantity.
6. being used for the drug abortion method of canine as claimed in claim 5, which is characterized in that physiology refers in the step S4
Mark parameter includes that body temperature, breathing situation, heart rate, blood pressure, electrocardiogram, blood routine, vim and vigour, liver function, kidney function and reproductive system are impaired.
7. the drug abortion method for canine stated such as claim 6, which is characterized in that the step S5 concrete operation step
For Aglepristone and dog grain to be uniformly mixed according to the ratio of 1:4000, and bait is made, monitors the work of public place wandering dog
Dynamic quantity, estimates the total weight of wandering dog, launches bait with the ratio of per kilogram of body weight 40g, and launch a bait daily, allows
Wandering dog is freely eaten, and bait is continuously launched one week, and being then spaced two weeks, persistently dispensing bait one week, circulation are thrown again
It puts bait half a year, monitoring wandering dog rutting and gestation farrowing situation, and random catching certain amount wandering dog checks gestation
State.
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| CN117649909A (en) * | 2024-01-29 | 2024-03-05 | 吉林省乾宇升科技有限公司 | Optimized matching method for biomedical clinical test |
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| CN104383195A (en) * | 2014-11-25 | 2015-03-04 | 烟台海研制药有限公司 | Traditional Chinese medicine composition for treating dog abortion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117649909A (en) * | 2024-01-29 | 2024-03-05 | 吉林省乾宇升科技有限公司 | Optimized matching method for biomedical clinical test |
| CN117649909B (en) * | 2024-01-29 | 2024-04-19 | 吉林省乾宇升科技有限公司 | Optimized matching method for biomedical clinical test |
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Application publication date: 20190319 |