CN109487269A - A kind of preparation method of antibiotic property composite coating - Google Patents
A kind of preparation method of antibiotic property composite coating Download PDFInfo
- Publication number
- CN109487269A CN109487269A CN201811405652.8A CN201811405652A CN109487269A CN 109487269 A CN109487269 A CN 109487269A CN 201811405652 A CN201811405652 A CN 201811405652A CN 109487269 A CN109487269 A CN 109487269A
- Authority
- CN
- China
- Prior art keywords
- coating
- preparation
- antibiotic property
- composite coating
- substrate surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C26/00—Coating not provided for in groups C23C2/00 - C23C24/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C24/00—Coating starting from inorganic powder
- C23C24/08—Coating starting from inorganic powder by application of heat or pressure and heat
- C23C24/10—Coating starting from inorganic powder by application of heat or pressure and heat with intermediate formation of a liquid phase in the layer
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
- C23C28/02—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings only including layers of metallic material
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Other Surface Treatments For Metallic Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of preparation methods with antibiotic property composite coating, laser burn processing first is carried out to matrix surface, then silver nitrate solution is coated on substrate surface, it is irradiated again with ultraviolet lamp, nano-Ag particles are made to be attached to porous surface, and form silver coating, HA and silver powder are mixed again, and the HA/Ag solution that compound concentration is 1-100mg/mL is stirred, then the sample with HA/Ag coating is obtained in substrate surface with dip-coating method, air drying, Laser Cladding Treatment finally is carried out to the sample of acquisition, so that the HA/Ag coating on substrate surface is combined closely with substrate.
Description
Technical field
The present invention relates to a kind of antibiotic property carboxy apatite composite coatings, belong to medical bio field of ceramic coatings.
Background technique
Hydroxyapatite has the chemical composition and crystal structure similar with main mine substance in human body bone and tooth, is
The main inorganic composition of body bone tissue is typical bioactive materials.But hydroxylapatite ceramic mechanical property is poor,
Bending strength and fracture toughness index are below human body dense bone, it is difficult to use at human body carrying position.It (is closed in metals such as titaniums
Gold) deposition hydroxylapatite ceramic coating can overcome the brittleness of hydroxyapatite body material on matrix, give full play to metal alloy
High intensity and high tenacity, improve the bearing capacity of implant.Meanwhile the good biological activated energy of hydroxyapatite makes implant
With the good combination of bone tissue.Using plasma spraying method, the hydroxyapatite coating layer prepared on the matrixes such as titanium alloy
It is clinically one of most widely used artificial bone substitution material, is widely used in hip prosthesis and tooth root planting body etc..
For bone substitution material during implant surgery, infection caused by bacterium accounts for considerable proportion.Normal use is various anti-
Raw element solves the problems, such as bacterium infection when operation, but increases bacterial antibiotic in the biomembrane that implant surface is formed
Drug resistance causes antibiotic drug effect to reduce.In order to more efficiently prevent from infection, on bone implant material surface, load antibacterial agent is one
Kind more effective method.Silver is a kind of most common inorganic antiseptic, has many advantages, such as efficient, safety, broad-spectrum antiseptic, wide
It is general to be applied in antibacterial product.
However, it is attached in substrate in the adhesive force of hydroxyapatite and raising carboxy apatite composite coating to improve silver
Put forth effort, still falls within a big technical problem.
Summary of the invention
The present invention provides a kind of preparation method with antibiotic property composite coating, comprising the following steps:
S1. laser burn processing is carried out to matrix surface, forms nanometer porous structure on surface；
S2. silver nitrate solution is coated on S1 treated substrate surface, then is irradiated with ultraviolet lamp, make nano silver
Grain is attached to porous surface, and forms silver coating；
S3. HA and silver powder are mixed, and the HA/Ag solution that compound concentration is 1-100mg/mL is stirred, and is then used
Dip-coating method obtains the sample with HA/Ag coating, air drying in substrate surface.
S4, Laser Cladding Treatment is carried out to the sample that step S3 is obtained, so that HA/Ag coating and substrate on substrate surface
It combines closely.
Preferably, the processing of laser burn described in S1 is utilized in the mode of line laser punching.
Preferably, the concentration of silver nitrate solution described in S2 is 1-100mM.
Preferably, the mass ratio of HA and silver powder described in S3 are 1-20:1.
Preferably, the silver powder partial size is 20-100 μm, and the partial size of the HA powder is 10-100 μm.
Preferably, the substrate is titanium or its alloy.
The beneficial effects of the present invention are:
First, first coarse porous nanometer structure is formed, is conducive to subsequent by the way of laser burn in substrate surface
Nano-Ag particles adhere to thereon；
Second, middle layer silver coating is increased as transition zone, is conducive to HA/Ag coating and is firmly adhered to thereon, further
Improve the adhesive force of coating；
Third, HA/Ag coating are handled using laser melting coating, can be realized HA/Ag coating and the base on substrate surface
Bottom is combined closely, and does not influence the anti-microbial property of coating.
Specific embodiment
Embodiment 1
A kind of preparation method with antibiotic property composite coating, comprising the following steps:
S1. laser burn processing is carried out to titanium alloy surface, forms nanometer porous structure on surface；
S2. 1mM silver nitrate solution is coated on S1 treated substrate surface, then the purple with wavelength 400nm, power 50W
Outer lamp is irradiated, and so that nano-Ag particles is attached to porous surface, and form silver coating；
S3. HA and silver powder are mixed, and the HA/Ag solution that compound concentration is 1mg/mL is stirred, then with dipping
Czochralski method obtains the sample with HA/Ag coating, air drying in substrate surface, and the silver powder partial size is 20 μm, the HA powder
The partial size at end is 10 μm, and the mass ratio of the HA and silver powder is 1:1；
S4, Laser Cladding Treatment is carried out to the sample that step S3 is obtained, so that HA/Ag coating and substrate on substrate surface
It combines closely.
Test shows that the HA/Ag coating anti-microbial property of titanium alloy surface is excellent, and adhesive force is high.
Embodiment 2
A kind of preparation method with antibiotic property composite coating, comprising the following steps:
S1. laser burn processing is carried out to titanium alloy surface, forms nanometer porous structure on surface；
S2. 50mM silver nitrate solution is coated on S1 treated substrate surface, then with wavelength 300nm, power 100W
Ultraviolet lamp is irradiated, and so that nano-Ag particles is attached to porous surface, and form silver coating；
S3. HA and silver powder are mixed, and the HA/Ag solution that compound concentration is 50mg/mL is stirred, then with dipping
Czochralski method obtains the sample with HA/Ag coating, air drying in substrate surface, and the silver powder partial size is 50 μm, the HA powder
The partial size at end is 50 μm, and the mass ratio of the HA and silver powder is 10:1；
S4, Laser Cladding Treatment is carried out to the sample that step S3 is obtained, so that HA/Ag coating and substrate on substrate surface
It combines closely.
Test shows that the HA/Ag coating anti-microbial property of titanium alloy surface is excellent, and adhesive force is high.
Embodiment 3
A kind of preparation method with antibiotic property composite coating, comprising the following steps:
S1. laser burn processing is carried out to titanium alloy surface, forms nanometer porous structure on surface；
S2. 100mM silver nitrate solution is coated on S1 treated substrate surface, then with wavelength 400nm, power 100W
Ultraviolet lamp is irradiated, and so that nano-Ag particles is attached to porous surface, and form silver coating；
S3. HA and silver powder are mixed, and the HA/Ag solution that compound concentration is 100mg/mL is stirred, then with leaching
Stain czochralski method obtains the sample with HA/Ag coating, air drying in substrate surface, and the silver powder partial size is 100 μm, the HA
The partial size of powder is 100 μm, and the mass ratio of the HA and silver powder is 20:1；
S4, Laser Cladding Treatment is carried out to the sample that step S3 is obtained, so that HA/Ag coating and substrate on substrate surface
It combines closely.
Test shows that the HA/Ag coating anti-microbial property of titanium alloy surface is excellent, and adhesive force is high.
Claims (6)
1. a kind of preparation method of antibiotic property composite coating, which comprises the following steps:
S1. laser burn processing is carried out to matrix surface, forms nanometer porous structure on surface；
S2. silver nitrate solution is coated on S1 treated substrate surface, then is irradiated with ultraviolet lamp, keep nano-Ag particles attached
In porous surface；
S3. HA and silver powder are mixed, and the HA/Ag solution that compound concentration is 1-100mg/mL is stirred, then with dipping
Czochralski method obtains the sample with HA/Ag coating, air drying in substrate surface.
S4, Laser Cladding Treatment is carried out to the sample that step S3 is obtained, so that the HA/Ag coating and substrate on substrate surface are close
In conjunction with.
2. a kind of preparation method of composite coating with antibiotic property according to claim 1, which is characterized in that described in S1
Laser burn processing is utilized in the mode of line laser punching.
3. a kind of preparation method of composite coating with antibiotic property according to claim 1, which is characterized in that described in S2
The concentration of silver nitrate solution is 1-100mM.
4. a kind of preparation method of composite coating with antibiotic property according to claim 1, which is characterized in that described in S3
HA and the mass ratio of silver powder are 1-20:1.
5. a kind of preparation method of composite coating with antibiotic property according to claim 1, which is characterized in that the silver
Powder diameter is 20-100 μm, and the partial size of the HA powder is 10-100 μm.
6. a kind of preparation method of composite coating with antibiotic property according to claim 1, which is characterized in that the base
Bottom is titanium or its alloy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811405652.8A CN109487269A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibiotic property composite coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811405652.8A CN109487269A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibiotic property composite coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109487269A true CN109487269A (en) | 2019-03-19 |
Family
ID=65697640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811405652.8A Pending CN109487269A (en) | 2018-11-23 | 2018-11-23 | A kind of preparation method of antibiotic property composite coating |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109487269A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111334746A (en) * | 2020-04-26 | 2020-06-26 | 广州珈鹏科技有限公司 | Biological ceramic coating with antibacterial activity and preparation method thereof |
| CN113088958A (en) * | 2021-03-09 | 2021-07-09 | 中南大学 | Gradient composite bioactive ceramic coating material and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127911A (en) * | 2014-07-21 | 2014-11-05 | 华中科技大学 | Preparation method of biological composite material using titanium alloy as implant |
-
2018
- 2018-11-23 CN CN201811405652.8A patent/CN109487269A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127911A (en) * | 2014-07-21 | 2014-11-05 | 华中科技大学 | Preparation method of biological composite material using titanium alloy as implant |
Non-Patent Citations (2)
| Title |
|---|
| XIANGMEI LIU 等: ""Laser fabrication of Ag-HA nanocomposites on Ti6Al4V implant for enhancing bioactivity and antibacterial capability"", 《MATERIALS SCIENCE AND ENGINEERING C》 * |
| 刘榕芳等: "两步法电沉积制备HA/ Ag复合涂层", 《应用化学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111334746A (en) * | 2020-04-26 | 2020-06-26 | 广州珈鹏科技有限公司 | Biological ceramic coating with antibacterial activity and preparation method thereof |
| CN113088958A (en) * | 2021-03-09 | 2021-07-09 | 中南大学 | Gradient composite bioactive ceramic coating material and preparation method thereof |
| CN113088958B (en) * | 2021-03-09 | 2021-12-28 | 中南大学 | Gradient composite bioactive ceramic coating material and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lin et al. | A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection | |
| Ullah et al. | Mechanical, biological, and antibacterial characteristics of plasma-sprayed (Sr, Zn) substituted hydroxyapatite coating | |
| Xue et al. | Surface modification techniques of titanium and its alloys to functionally optimize their biomedical properties: thematic review | |
| Liu et al. | Nano-modified titanium implant materials: a way toward improved antibacterial properties | |
| Lu et al. | Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemical deposition | |
| Erakovic et al. | Corrosion stability and bioactivity in simulated body fluid of silver/hydroxyapatite and silver/hydroxyapatite/lignin coatings on titanium obtained by electrophoretic deposition | |
| Sarraf et al. | Silver oxide nanoparticles-decorated tantala nanotubes for enhanced antibacterial activity and osseointegration of Ti6Al4V | |
| US6984392B2 (en) | Antimicrobial material for implanting in bones | |
| Sarraf et al. | Highly-ordered TiO2 nanotubes decorated with Ag2O nanoparticles for improved biofunctionality of Ti6Al4V | |
| Kaliaraj et al. | Surface functionalized bioceramics coated on metallic implants for biomedical and anticorrosion performance–a review | |
| Zhao et al. | Influence of silver-hydroxyapatite nanocomposite coating on biofilm formation of joint prosthesis and its mechanism | |
| Shimabukuro et al. | Investigation of realizing both antibacterial property and osteogenic cell compatibility on titanium surface by simple electrochemical treatment | |
| Guo et al. | Poly-l-lysine/sodium alginate coating loading nanosilver for improving the antibacterial effect and inducing mineralization of dental implants | |
| Saleem et al. | Fabrication and characterization of Ag–Sr-substituted hydroxyapatite/chitosan coatings deposited via electrophoretic deposition: a design of experiment study | |
| Zhang et al. | Antimicrobial peptide-loaded pectolite nanorods for enhancing wound-healing and biocidal activity of titanium | |
| Nouri et al. | Surface modification of additively manufactured metallic biomaterials with active antipathogenic properties | |
| Narayan et al. | Laser processing of advanced bioceramics | |
| Priyadarshini et al. | Structural, morphological and biological evaluations of cerium incorporated hydroxyapatite sol–gel coatings on Ti–6Al–4V for orthopaedic applications | |
| Shtansky et al. | Recent progress in the field of multicomponent bioactive nanostructured films | |
| Li et al. | Porous titanium scaffold surfaces modified with silver loaded gelatin microspheres and their antibacterial behavior | |
| CN109487269A (en) | A kind of preparation method of antibiotic property composite coating | |
| Petrochenko et al. | Nanosilver-PMMA composite coating optimized to provide robust antibacterial efficacy while minimizing human bone marrow stromal cell toxicity | |
| Rahnejat et al. | Promoting osteoblast proliferation and differentiation on functionalized and laser treated titanium substrate using hydroxyapatite/β-tricalcium phosphate/silver nanoparticles | |
| Zhao et al. | Promotion of bone formation and antibacterial properties of titanium coated with porous Si/Ag-doped titanium dioxide | |
| Wang et al. | Cytotoxicity and antibacterial efficacy of silver nanoparticles deposited onto dopamine-functionalised titanium |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190319 |
|
| RJ01 | Rejection of invention patent application after publication |