CN109481728A - A kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation - Google Patents
A kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation Download PDFInfo
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- CN109481728A CN109481728A CN201811314021.5A CN201811314021A CN109481728A CN 109481728 A CN109481728 A CN 109481728A CN 201811314021 A CN201811314021 A CN 201811314021A CN 109481728 A CN109481728 A CN 109481728A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The present invention provides a kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation, is related to medical production technical field.The pectin aerogel dressing is made of raw material from the following weight: pectin: 35-45 parts, chitosan: 5-15 parts, vitamin E: 4-6 parts, reparation Essence: 4-6 parts, collagen: 2-4 parts, amino acid: 2-4 parts, hyaluronic acid: 1-2 parts, sulphur: 2-4 parts, B3:2-4 parts of vitamin, crosslinking agent: 1-2 parts.The present invention overcomes the deficiencies in the prior art, can effectively improve the healing speed and curative effect of aerogel dressing, additionally it is possible to which quick anti-inflammatory subtracts swollen, adjusting wound ulcer and promotes recovery from illness, accelerate the growth of newborn epithelium and granulation tissue, repairing effect is good, at the same can effective antibacterial, be suitable for promote.
Description
Technical field
The present invention relates to medical production technical fields, and in particular to a kind of pectin hydrogel for wound ulcer reparation is deposited
Material and preparation method thereof.
Background technique
Aerogel dressing is the novel wound dressing of one kind developed in recent years.Compared with traditional dressing, water-setting
The pain that glue can promote wound healing, mitigate patient, it can improve the microenvironment of the surface of a wound, inhibit the growth of bacterium.Hydrogel is special
Body surface wound that Shi Yongyu be uncommon, such as scratch, scratch, the various skin injuries of bedsore.
Pectin is a kind of natural polymer, has good gelatine and stable emulsifying effect, is widely used in
Food, medicine, daily use chemicals and textile industry.In medical field, pectin has the effect of protection skin, accelerating wound healing.
Current aerogel dressing is prepared usually based on sodium alginate, supplemented by polyvinyl alcohol, the formula and preparation
Method is all more traditional, can only carry out rapid healing to lighter skin injury.When needing to cure, ulcer equivalent damage is more serious
When wound, the effect of current aerogel dressing is difficult to reach rapid healing and repairs, curative effect is slower, medicinal efficacy compared with
Difference.The aerogel dressing for being accordingly used in wound ulcer reparation is the emphasis of researchers' research.
Summary of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of pectin aerogel dressing and its system for wound ulcer reparation
Preparation Method and preparation method thereof, the present invention overcomes the deficiencies in the prior art, can effectively improve the healing speed of aerogel dressing
And curative effect, additionally it is possible to which quick anti-inflammatory subtracts swollen, adjusting wound ulcer and promotes recovery from illness, accelerates newborn epithelium and granulation group
The growth knitted, repairing effect is good, at the same can effective antibacterial, be suitable for promote.
In order to achieve the above object, technical solution of the present invention is achieved by the following technical programs:
A kind of pectin aerogel dressing for wound ulcer reparation, the pectin aerogel dressing is by following parts by weight
Raw material is made: pectin: 35-45 parts, chitosan: 5-15 parts, vitamin E: 4-6 parts, reparation Essence: 4-6 parts, collagen:
2-4 parts, amino acid: 2-4 parts, hyaluronic acid: 1-2 parts, sulphur: 2-4 parts, B3:2-4 parts of vitamin, crosslinking agent: 1-2 parts.
Preferably, the pectin aerogel dressing is made of raw material from the following weight: pectin: 40 parts, chitosan: 10
Part, vitamin E: 5 parts, reparation Essence: 5 parts, collagen: 3 parts, amino acid: 3 parts, hyaluronic acid: 1.5 parts, sulphur: 3
Part, B3:3 parts of vitamin, crosslinking agent: 1.5 parts.
Preferably, the Essence of repairing is one in aloe essence, mulberry leaf essence, rose essence and pot marigold essence
Kind is a variety of.
Preferably, the crosslinking agent is N hydroxymethyl acrylamide, tetramethyl -1,2- ethylene diamine, hexa-methylene four
One of amine, Dihydroxyaluminium Aminoacetate and calcium chloride are a variety of.
Preferably, the pectin aerogel dressing preparation method the following steps are included:
(1) deionized water of 2-4 times of volume is added after mixing pectin and chitosan in ultrasonic vibration instrument, surpasses after heating
A period of time is swung in acoustic shock, and it is spare to obtain pectin hydrogel base fluid；
(2) the pectin hydrogel base fluid in above-mentioned steps (1) is poured into blender, adds crosslinking agent, while stirring
It is spare that heating heating a period of time obtains pectin water-setting collagen solution；
(3) high speed disperser is added after mixing vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid
In, the deionized water of 4-6 times of volume is added, it is spare that high speed dispersion must repair auxiliary material afterwards for a period of time；
(4) sulphur is ground to after granularity is 0.3-0.7mm and is mixed with vitamin B3, then be mixed object and above-mentioned steps
(3) the reparation auxiliary material mixing in, feeds the mixture into the blender in above-mentioned steps (2) after mixing, continues to be stirred one
It filters and evaporates after the section time, then stand de-bubble to obtain pectin gel aqueous fluid spare；
(5) the pectin gel aqueous fluid in above-mentioned steps (4) is poured into mold, using sterilizing after electron beam radiation curable,
Obtain product.
Preferably, 45-55 DEG C is warming up in step (1), the frequency of ultrasonic vibration instrument is 25-30kHz, and the ultrasonic sound intensity is 2-
3W/cm2, ultrasonic time 5-10min.
Preferably, adjustment revolving speed is to 300-400r/min in step (2), and heating temperature is 55-65 DEG C, mixing time 1-
2h。
Preferably, mixing time is 2-3h in step (4), and evaporating temperature is 80-90 DEG C, evaporation time 2-4h, is stood
Time is 1-2h.
The present invention provides a kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation, with the prior art
It is compared to advantage:
(1) present invention uses major ingredient of the pectin as aerogel dressing, and the spy of skin, accelerating wound healing is protected using it
Property, the healing speed and curative effect of aerogel dressing are effectively increased, even in the case where wound ulcer, can still provide for very
Good healing, by with chitosan ultrasonic vibration, mix afterwards with crosslinking agent so that pectin be easier to the mutual cooperation of other auxiliary materials, from
And the whole stability for improving pectin aerogel dressing, medicinal effects are good；
(2) present invention is using auxiliary as repairing using vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid
Material, can quickly anti-inflammatory subtract it is swollen, adjust wound ulcer and promote recovery from illness, repairing effect is good, wherein vitamin E and repair Essence
It cooperates, the repair function of dressing can be effectively improved, and collagen and amino acid cooperate, and accelerate the upper of new life
The growth of skin and granulation tissue, repair function are good；
(3) present invention adds sulphur and vitamin B3 into dressing raw material, can effectively antibacterial, remove it is micro- in wound surface
Biology prevents bacterium infection, accelerates wound healing, is suitable for promoting.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below with reference to the embodiment of the present invention pair
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is a part of the invention
Embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making wound
Every other embodiment obtained under the premise of the property made labour, shall fall within the protection scope of the present invention.
Embodiment 1:
A kind of pectin aerogel dressing for wound ulcer reparation, the pectin aerogel dressing is by following parts by weight
Raw material is made: pectin: 35 parts, chitosan: 5 parts, vitamin E: 4 parts, reparation Essence: 4 parts, collagen: 2 parts, amino acid:
2 parts, hyaluronic acid: 1 part, sulphur: 2 parts, B3:2 parts of vitamin, crosslinking agent: 1 part.
The preparation method of the pectin aerogel dressing the following steps are included:
(1) deionized water of 2-4 times of volume is added after mixing pectin and chitosan in ultrasonic vibration instrument, surpasses after heating
A period of time is swung in acoustic shock, and it is spare to obtain pectin hydrogel base fluid；
(2) the pectin hydrogel base fluid in above-mentioned steps (1) is poured into blender, adds crosslinking agent, while stirring
It is spare that heating heating a period of time obtains pectin water-setting collagen solution；
(3) high speed disperser is added after mixing vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid
In, the deionized water of 4-6 times of volume is added, it is spare that high speed dispersion must repair auxiliary material afterwards for a period of time；
(4) sulphur is ground to after granularity is 0.3-0.7mm and is mixed with vitamin B3, then be mixed object and above-mentioned steps
(3) the reparation auxiliary material mixing in, feeds the mixture into the blender in above-mentioned steps (2) after mixing, continues to be stirred one
It filters and evaporates after the section time, then stand de-bubble to obtain pectin gel aqueous fluid spare；
(5) the pectin gel aqueous fluid in above-mentioned steps (4) is poured into mold, using sterilizing after electron beam radiation curable,
Obtain product.
Wherein, the reparation Essence is one of aloe essence, mulberry leaf essence, rose essence and pot marigold essence
Or it is a variety of；The crosslinking agent is N hydroxymethyl acrylamide, tetramethyl -1,2- ethylene diamine, hexa, Dihydroxyaluminium Aminoacetate
With one of calcium chloride or a variety of；45-55 DEG C is warming up in step (1), the frequency of ultrasonic vibration instrument is 25-30kHz, ultrasound
The sound intensity is 2-3W/cm2, ultrasonic time 5-10min；To 300-400r/min, heating temperature is adjustment revolving speed in step (2)
55-65 DEG C, mixing time 1-2h；Mixing time is 2-3h in step (4), and evaporating temperature is 80-90 DEG C, evaporation time 2-
4h, time of repose 1-2h.
Embodiment 2:
A kind of pectin aerogel dressing for wound ulcer reparation, the pectin aerogel dressing is by following parts by weight
Raw material is made: pectin: 40 parts, chitosan: 10 parts, vitamin E: 5 parts, reparation Essence: 5 parts, collagen: 3 parts, amino
Acid: 3 parts, hyaluronic acid: 1.5 parts, sulphur: 3 parts, B3:3 parts of vitamin, crosslinking agent: 1.5 parts.
The preparation method of the pectin aerogel dressing the following steps are included:
(1) deionized water of 2-4 times of volume is added after mixing pectin and chitosan in ultrasonic vibration instrument, surpasses after heating
A period of time is swung in acoustic shock, and it is spare to obtain pectin hydrogel base fluid；
(2) the pectin hydrogel base fluid in above-mentioned steps (1) is poured into blender, adds crosslinking agent, while stirring
It is spare that heating heating a period of time obtains pectin water-setting collagen solution；
(3) high speed disperser is added after mixing vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid
In, the deionized water of 4-6 times of volume is added, it is spare that high speed dispersion must repair auxiliary material afterwards for a period of time；
(4) sulphur is ground to after granularity is 0.3-0.7mm and is mixed with vitamin B3, then be mixed object and above-mentioned steps
(3) the reparation auxiliary material mixing in, feeds the mixture into the blender in above-mentioned steps (2) after mixing, continues to be stirred one
It filters and evaporates after the section time, then stand de-bubble to obtain pectin gel aqueous fluid spare；
(5) the pectin gel aqueous fluid in above-mentioned steps (4) is poured into mold, using sterilizing after electron beam radiation curable,
Obtain product.
Wherein, the reparation Essence is one of aloe essence, mulberry leaf essence, rose essence and pot marigold essence
Or it is a variety of；The crosslinking agent is N hydroxymethyl acrylamide, tetramethyl -1,2- ethylene diamine, hexa, Dihydroxyaluminium Aminoacetate
With one of calcium chloride or a variety of；45-55 DEG C is warming up in step (1), the frequency of ultrasonic vibration instrument is 25-30kHz, ultrasound
The sound intensity is 2-3W/cm2, ultrasonic time 5-10min；To 300-400r/min, heating temperature is adjustment revolving speed in step (2)
55-65 DEG C, mixing time 1-2h；Mixing time is 2-3h in step (4), and evaporating temperature is 80-90 DEG C, evaporation time 2-
4h, time of repose 1-2h.
Embodiment 3:
A kind of pectin aerogel dressing for wound ulcer reparation, the pectin aerogel dressing is by following parts by weight
Raw material is made: pectin: 45 parts, chitosan: 15 parts, vitamin E: 6 parts, reparation Essence: 6 parts, collagen: 4 parts, amino
Acid: 4 parts, hyaluronic acid: 2 parts, sulphur: 4 parts, B3:4 parts of vitamin, crosslinking agent: 2 parts.
The preparation method of the pectin aerogel dressing the following steps are included:
(1) deionized water of 2-4 times of volume is added after mixing pectin and chitosan in ultrasonic vibration instrument, surpasses after heating
A period of time is swung in acoustic shock, and it is spare to obtain pectin hydrogel base fluid；
(2) the pectin hydrogel base fluid in above-mentioned steps (1) is poured into blender, adds crosslinking agent, while stirring
It is spare that heating heating a period of time obtains pectin water-setting collagen solution；
(3) high speed disperser is added after mixing vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid
In, the deionized water of 4-6 times of volume is added, it is spare that high speed dispersion must repair auxiliary material afterwards for a period of time；
(4) sulphur is ground to after granularity is 0.3-0.7mm and is mixed with vitamin B3, then be mixed object and above-mentioned steps
(3) the reparation auxiliary material mixing in, feeds the mixture into the blender in above-mentioned steps (2) after mixing, continues to be stirred one
It filters and evaporates after the section time, then stand de-bubble to obtain pectin gel aqueous fluid spare；
(5) the pectin gel aqueous fluid in above-mentioned steps (4) is poured into mold, using sterilizing after electron beam radiation curable,
Obtain product.
Wherein, the reparation Essence is one of aloe essence, mulberry leaf essence, rose essence and pot marigold essence
Or it is a variety of；The crosslinking agent is N hydroxymethyl acrylamide, tetramethyl -1,2- ethylene diamine, hexa, Dihydroxyaluminium Aminoacetate
With one of calcium chloride or a variety of；45-55 DEG C is warming up in step (1), the frequency of ultrasonic vibration instrument is 25-30kHz, ultrasound
The sound intensity is 2-3W/cm2, ultrasonic time 5-10min；To 300-400r/min, heating temperature is adjustment revolving speed in step (2)
55-65 DEG C, mixing time 1-2h；Mixing time is 2-3h in step (4), and evaporating temperature is 80-90 DEG C, evaporation time 2-
4h, time of repose 1-2h.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (8)
1. a kind of pectin aerogel dressing for wound ulcer reparation, which is characterized in that the pectin aerogel dressing by with
The raw material of lower parts by weight is made: pectin: 35-45 parts, chitosan: 5-15 parts, vitamin E: 4-6 parts, reparation Essence: 4-6 parts,
Collagen: 2-4 parts, amino acid: 2-4 parts, hyaluronic acid: 1-2 parts, sulphur: 2-4 parts, B3:2-4 parts of vitamin, crosslinking agent:
1-2 parts.
2. a kind of pectin aerogel dressing for wound ulcer reparation according to claim 1, which is characterized in that described
Pectin aerogel dressing is made of raw material from the following weight: pectin: 40 parts, chitosan: 10 parts, vitamin E: 5 parts, reparation essence
Magnificent liquid: 5 parts, collagen: 3 parts, amino acid: 3 parts, hyaluronic acid: 1.5 parts, sulphur: 3 parts, B3:3 parts of vitamin, crosslinking agent:
1.5 part.
3. a kind of pectin aerogel dressing for wound ulcer reparation according to claim 1 to 2, which is characterized in that institute
Stating and repairing Essence is one of aloe essence, mulberry leaf essence, rose essence and pot marigold essence or a variety of.
4. a kind of pectin aerogel dressing for wound ulcer reparation according to claim 1 to 2, which is characterized in that institute
Stating crosslinking agent is N hydroxymethyl acrylamide, tetramethyl -1,2- ethylene diamine, hexa, Dihydroxyaluminium Aminoacetate and calcium chloride
One of or it is a variety of.
5. a kind of preparation method of the pectin aerogel dressing for wound ulcer reparation, which is characterized in that the pectin water-setting
The preparation method of glue dressing the following steps are included:
(1) deionized water of 2-4 times of volume is added after mixing pectin and chitosan in ultrasonic vibration instrument, ultrasound shake after heating
A period of time is swung, it is spare to obtain pectin hydrogel base fluid；
(2) the pectin hydrogel base fluid in above-mentioned steps (1) is poured into blender, adds crosslinking agent, warming while stirring
It is spare that heating a period of time obtains pectin water-setting collagen solution；
(3) it is added in high speed disperser after mixing vitamin E, reparation Essence, collagen, amino acid and hyaluronic acid,
The deionized water of 4-6 times of volume is added, it is spare that high speed dispersion must repair auxiliary material afterwards for a period of time；
(4) sulphur is ground to after granularity is 0.3-0.7mm and is mixed with vitamin B3, then be mixed object and above-mentioned steps (3)
In reparation auxiliary material mixing, fed the mixture into after mixing in the blender in above-mentioned steps (2), when continuing to be stirred one section
Between after filter and evaporate, then stand de-bubble to obtain pectin gel aqueous fluid spare；
(5) the pectin gel aqueous fluid in above-mentioned steps (4) is poured into mold, using sterilizing after electron beam radiation curable, is obtained
Product.
6. a kind of preparation method of pectin aerogel dressing for wound ulcer reparation according to claim 5, special
Sign is: 45-55 DEG C is warming up in step (1), the frequency of ultrasonic vibration instrument is 25-30kHz, and the ultrasonic sound intensity is 2-3W/cm2,
Ultrasonic time is 5-10min.
7. a kind of preparation method of pectin aerogel dressing for wound ulcer reparation according to claim 5, special
Sign is: adjustment revolving speed is to 300-400r/min in step (2), and heating temperature is 55-65 DEG C, mixing time 1-2h.
8. a kind of preparation method of pectin aerogel dressing for wound ulcer reparation according to claim 5, special
Sign is: mixing time is 2-3h in step (4), and evaporating temperature is 80-90 DEG C, evaporation time 2-4h, time of repose 1-
2h。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811314021.5A CN109481728A (en) | 2018-11-06 | 2018-11-06 | A kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811314021.5A CN109481728A (en) | 2018-11-06 | 2018-11-06 | A kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation |
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| CN109481728A true CN109481728A (en) | 2019-03-19 |
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| CN201811314021.5A Pending CN109481728A (en) | 2018-11-06 | 2018-11-06 | A kind of pectin aerogel dressing and preparation method thereof for wound ulcer reparation |
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| CN (1) | CN109481728A (en) |
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| CN110917390A (en) * | 2019-11-25 | 2020-03-27 | 江苏普罗诺生物科技有限公司 | Technological formula of cold compress gel for wound repair |
| CN111110831A (en) * | 2020-02-20 | 2020-05-08 | 柳州市工人医院 | Ulcer paste and preparation method thereof |
| CN114712553A (en) * | 2022-04-11 | 2022-07-08 | 浙江理工大学 | Preparation method of wound dressing based on shaddock peel pectin-oxidized chitosan composite hydrogel |
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| US20090068246A1 (en) * | 2007-08-01 | 2009-03-12 | Kinney William A | Collagen-related peptides and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917390A (en) * | 2019-11-25 | 2020-03-27 | 江苏普罗诺生物科技有限公司 | Technological formula of cold compress gel for wound repair |
| CN111110831A (en) * | 2020-02-20 | 2020-05-08 | 柳州市工人医院 | Ulcer paste and preparation method thereof |
| CN111110831B (en) * | 2020-02-20 | 2023-08-08 | 柳州市工人医院 | Ulcer paste and preparation method thereof |
| CN114712553A (en) * | 2022-04-11 | 2022-07-08 | 浙江理工大学 | Preparation method of wound dressing based on shaddock peel pectin-oxidized chitosan composite hydrogel |
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Application publication date: 20190319 |