CN109481070B - Implantable internal carotid artery constant-speed injection device and operation method thereof - Google Patents
Implantable internal carotid artery constant-speed injection device and operation method thereof Download PDFInfo
- Publication number
- CN109481070B CN109481070B CN201910021986.3A CN201910021986A CN109481070B CN 109481070 B CN109481070 B CN 109481070B CN 201910021986 A CN201910021986 A CN 201910021986A CN 109481070 B CN109481070 B CN 109481070B
- Authority
- CN
- China
- Prior art keywords
- carotid artery
- injection
- catheter
- constant
- common carotid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
Abstract
The invention discloses an implantable internal carotid artery constant-speed injection device and an operation method thereof. The invention adopts a sealing cover and a sealing plug which are respectively arranged at the top end and the rear end of a carotid artery implantation catheter, namely the sealing cover and the sealing plug can be penetrated by a needle, an injection opening covered by a unidirectional flow gate is arranged at the front end of the carotid artery implantation catheter, the flow speed and the time are controlled by a controller, a constant-speed injection micropump is driven to push an injector, and cancer cells or injection medicines flow into a carotid artery vessel through the injection opening of the carotid artery implantation catheter; the invention can simplify the operation method, simplify the operation steps and shorten the operation time; meanwhile, the operation mode of the animal model injected into the internal carotid artery of the mouse is completely changed, the external carotid artery of the mouse is not required to be sutured, the vagus nerve and the blood vessel are not damaged, and the success rate of the operation is greatly improved.
Description
Technical Field
The invention relates to a mouse animal model technology, in particular to an implantable internal carotid artery constant-speed injection device and an operation method thereof.
Background
When preparing a mouse animal model for brain metastasis of various cancer cells, the proximal end of the common carotid artery and the external carotid artery of the mouse are usually required to be ligated, then the cancer cells cultured in vitro are injected into the internal carotid artery from the distal end of the common carotid artery by using an injector to reach the blood brain barrier, and spontaneously metastasize into the brain, so as to prepare the mouse animal model most similar to the brain metastasis of human cancer. From the local anatomy it is known that: the common carotid artery is divided forward into the external carotid artery and the internal carotid artery, with only the blood in the internal carotid artery flowing intracranially. Thus, only ligating the external carotid artery will allow blood flow in the common carotid artery to flow all the way forward into the internal carotid artery. Since the operation of the mouse needs to be carried out under a microscope, the operation must be very fine, the most critical step in the operation process is to ligate the external carotid artery of the mouse, then the cancer cells can be completely injected into the internal carotid artery to transfer to the brain by using a syringe, and the attendant vagus nerve and vein blood vessels must be protected from damage when the external carotid artery is sutured, otherwise, cardiac arrest and blood loss of the mouse are caused, which is an important cause of death of the mouse after the operation failure. In addition, after ligating the external carotid artery, the needle of the injector filled with cancer cells needs to be penetrated into the distal end of the common carotid artery (above the proximal ligature), and then the external cultured cancer cells are injected into the internal carotid artery, and the injection process needs to strictly control the injection speed, namely under the condition that the concentration of the cancer cells is fixed, the faster the injection speed is, the more the number of the cancer cells reaching the blood brain barrier in unit time is, the cancer plugs can be artificially caused to block blood vessels, which is equivalent to causing the death of mice due to the large-area thrombotic diseases, and is another important cause of death of mice with failed operations.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides an implantable carotid artery constant-speed injection device and an operation method thereof, so as to improve the success rate of manufacturing a mouse animal model and reduce the death rate of the mouse.
It is an object of the present invention to provide an implantable internal carotid artery constant-velocity injection device.
The implantable internal carotid artery constant-speed injection device of the invention comprises: the common carotid artery implantation catheter, the sealing cover, the sealing plug, the injection opening, the unidirectional flow gate, the marker, the needle, the injector, the propeller, the constant-speed injection micro pump and the controller; wherein, the common carotid artery implantation catheter is a cylindrical hollow catheter with hollow inside; the top end of the carotid artery implanted catheter is provided with a sealing cover, and the rear end is provided with a sealing plug; an injection opening is arranged on the side wall of the front end of the carotid artery implantation catheter; a unidirectional flow gate is arranged at the injection opening and positioned outside the carotid artery implantation catheter and covers the injection opening, the front end of the unidirectional flow gate is connected to the side wall of the front end of the carotid artery implantation catheter, and the unidirectional flow gate can be opened and closed outside the carotid artery implantation catheter around the connection position; a marker is arranged at the front end of the common carotid artery implantation catheter; the common carotid artery implantation catheter, the sealing cover, the sealing plug, the injection opening, the unidirectional flow gate and the marker form a common carotid artery implantation device; the front end of the injector is connected with a needle head, and the shape of the needle head is a folded line type with an obtuse angle; the needle penetrates the sealing plug and goes deep into the carotid artery implantation catheter; the piston handle at the bottom end of the injector is connected to the propeller; the propeller is connected to a constant-speed injection micro pump; the constant-speed injection micropump is connected to the controller; the empty cylinder of the injector is filled with the injection, the injection rate is set by the controller, the constant-speed injection micro pump is controlled to drive the propeller, the piston handle of the injector is pushed, the injection is injected into the carotid artery implantation catheter through the needle, and the injection flows out through the injection opening and the one-way flow gate; after the injection is finished, the unidirectional flow gate is closed because the pressure of the blood reflux is stronger than the pressure in the carotid artery implantation catheter, namely the carotid artery implantation catheter is negative pressure.
Before the operation, the carotid artery implantation catheter is inserted into the carotid artery blood vessel, and after the operation is finished, the carotid artery implantation catheter is taken out.
The common carotid artery implantation catheter is made of polyvinyl chloride PVC, polyethylene PE or polystyrene PS. The internal diameter of the common carotid artery implantation catheter is 0.5-0.75 mm; the outer diameter is 1-1.25 mm.
The sealing cover and the sealing plug are made of one of rubber, latex and silica gel.
The diameter of the injection opening is 1-2 mm, and the distance between the injection opening and the top end of the carotid artery implantation catheter is 3-4 mm. The invention adopts the sealing cover to seal the top end of the common carotid artery implantation catheter, and the side wall of the common carotid artery implantation catheter is provided with the injection opening, so that the injection is completely injected into the internal carotid artery, the external carotid artery of a mouse is not required to be sutured, and the vagus nerve and the blood vessel are not damaged.
The one-way flow gate is arranged outside the injection opening, in the injection process, the injection can flow out by flushing the one-way flow gate, and after the injection is finished, the one-way flow gate is closed to cover the injection opening due to negative pressure in the carotid implanted catheter, so that blood in the carotid artery is prevented from flowing back into the carotid implanted catheter.
The marker adopts an indication strip, and the surface of the indication strip is coated with a fluorescent agent; the indicator strip is tightly adhered to the inner surface of the sealing cover.
The obtuse angle of the needle head is 120-145 degrees, so that the puncture operation of the common carotid artery blood vessel is facilitated, the common carotid artery implantation catheter is more convenient to implant, and the common carotid artery blood vessel of a mouse cannot be damaged when the injection operation is performed.
The injector comprises a hollow cylinder, a piston and a piston handle; the top of the hollow cylinder is provided with a communicated needle head, the bottom of the piston is provided with a piston handle, and the front end of the piston penetrates into the hollow cylinder from the bottom of the hollow cylinder.
The propeller comprises a push head and a screw rod; the front end of the push head is connected with a piston handle of the injector, the rear end of the push head is connected with a screw rod, and the screw rod is connected to the constant-speed injection micro pump. The constant-speed injection micro pump is controlled by the controller, a control signal of the controller drives the constant-speed injection micro pump to drive the screw rod to rotate, the screw rod drives the front end push head to advance, and the push head can convert the rotary motion of the screw rod pair into linear motion, so that the piston of the injector at the front end of the push head is pushed to inject cancer cells or medicines.
The controller comprises a power supply, an input device, an output device and a control circuit board; wherein, the power supply is respectively connected to the input device, the output device and the control circuit board; the control circuit board is respectively connected to the input device and the output device; the infusion speed, the injection time and the total injection amount are set through an input device, a display screen is adopted as an output device, and the display screen is a Liquid Crystal Display (LCD). The advancing speed of the piston of the injector is controlled by setting the infusion speed and the injection time of the constant-speed injection micro pump so as to control the rotating speed of the screw.
The dosage of the injection is 500-200 mu l; the constant injection rate is 0.50-1.0 mu l/s, and the injection time is 100-200 s.
Further, the invention also comprises a protective sleeve which is sleeved outside the common carotid artery implantation device.
The injectate is various cancer cells transferred to brain or various injection medicines for treatment.
It is another object of the present invention to provide a method of operating an implantable internal carotid artery constant velocity injection device.
The operation method of the implantable internal carotid artery constant-speed injection device comprises the following steps:
1) Filling the syringe with the injectate;
2) Connecting a piston handle at the bottom end of the injector to the propeller;
3) Connecting the propeller to a constant speed injection micro pump;
4) Connecting a constant-speed injection micropump to a controller;
5) Penetrating the sealing plug with the needle having the obtuse angle into the carotid artery implantation catheter; penetrating the sealing cover to expose the needle tip;
6) The needle tip is retreated back to the common carotid artery to be implanted in the catheter;
7) Setting the injection rate through a controller, controlling a constant-speed injection micro pump to drive a propeller, pushing a piston handle of the syringe, injecting an injection into the common carotid artery implantation catheter through a needle, and flushing a one-way flow gate through an injection opening to flow out;
8) After the injection is finished, the unidirectional flow gate is closed because the internal of the carotid artery implanted catheter is negative pressure.
The invention has the advantages that:
the invention adopts a sealing cover and a sealing plug which are respectively arranged at the top end and the rear end of a carotid artery implantation catheter, namely the sealing cover and the sealing plug can be penetrated by a needle, an injection opening covered by a unidirectional flow gate is arranged at the front end of the carotid artery implantation catheter, the flow speed and the time are controlled by a controller, a constant-speed injection micropump is driven to push an injector, and cancer cells or injection medicines flow into a carotid artery vessel through the injection opening of the carotid artery implantation catheter; the invention can simplify the operation method, simplify the operation steps and shorten the operation time; meanwhile, the operation mode of the animal model injected into the internal carotid artery of the mouse is completely changed, the external carotid artery of the mouse is not required to be sutured, the vagus nerve and the blood vessel are not damaged, and the success rate of the operation is greatly improved.
Drawings
FIG. 1 is a schematic view of one embodiment of a common carotid artery implant device of the present invention;
FIG. 2 is a schematic view of one embodiment of an implantable internal carotid constant velocity injection device of the invention prior to use;
figure 3 is a schematic view of the connection of one embodiment of the implantable internal carotid constant velocity injection device of the invention in use.
Detailed Description
The invention will be further elucidated by means of specific embodiments in conjunction with the accompanying drawings.
As shown in fig. 1 and 2, the implantable internal carotid artery constant-speed injection device of the present embodiment includes: the common carotid artery implantation catheter 1, the sealing cover 2, the sealing plug 3, the injection opening, the unidirectional flow gate 4, the marker, the needle 5, the injector 6, the protective sleeve 7, the propeller, the constant-speed injection micro pump and the controller; wherein, the common carotid artery implantation catheter 1 is a cylindrical hollow catheter with hollow inside; the top end of the carotid artery implanted catheter 1 is provided with a sealing cover 2, and the rear end is provided with a sealing plug 3; an injection opening is arranged on the side wall of the front end of the carotid artery implantation catheter 1; a unidirectional flow gate is arranged at the injection opening and positioned outside the carotid artery implantation catheter 1, the injection opening is covered, the front end of the unidirectional flow gate is connected to the side wall of the front end of the carotid artery implantation catheter 1, and the unidirectional flow gate can be opened and closed outside the carotid artery implantation catheter 1 around the connection position; a marker is arranged at the front end of the carotid artery implantation catheter 1; the common carotid artery implantation catheter 1, the sealing cover 2, the sealing plug 3, the injection opening, the unidirectional flow gate 4 and the marker form a common carotid artery implantation device; the protective sleeve 7 is sleeved outside the common carotid artery implantation device; the front end of the injector 6 is connected with a needle head 5, and the needle head 5 is shaped as a folded line with an obtuse angle; the needle 5 penetrates the sealing plug 3 and penetrates into the carotid artery implantation catheter 1; the piston handle at the bottom end of the injector 6 is connected to the propeller; the propeller is connected to a constant-speed injection micro pump; the constant-speed injection micropump is connected to the controller; the empty cylinder of the injector 6 is filled with injection, the injection rate is set by the controller, the constant-speed injection micro pump is controlled to drive the propeller, the piston handle of the injector 6 is pushed, the injection is injected into the common carotid artery implantation catheter 1 through the needle 5, and the injection flows out through the injection opening and the single-direction flow gate; after the injection is finished, the unidirectional flow gate is closed because the pressure of the blood reflux is stronger than the pressure in the carotid artery implanted catheter 1, namely, the carotid artery implanted catheter 1 is negative pressure. The syringe 6 comprises a hollow barrel 61, a piston 62 and a piston stem 63.
In the embodiment, the common carotid artery implantation catheter 1 adopts polyvinyl chloride PVC; rubber is adopted as the material of the sealing cover 2 and the sealing plug 3; the diameter of the injection opening was 1mm and the distance from the top of the carotid artery implanted catheter 1 was 3mm. The marker adopts an indication strip, and the surface of the indication strip is coated with fluorescent agent and is tightly adhered to the inner surface of the sealing cover 2; the obtuse angle of the needle 5 is 135 degrees; the dose of the implant was 100 μl; the constant injection rate was 0.50. Mu.l/s and the injection time was between 100 and 200s.
The implantable carotid artery constant-speed injection device of the embodiment is used in the operation of injecting carotid artery of a mouse, and as shown in fig. 3, the operation method comprises the following steps:
1) Filling the syringe 6 with cancer cells or a drug;
2) Connecting a piston handle at the bottom end of the injector 6 to the propeller;
3) Connecting the propeller to a constant speed injection micro pump;
4) Connecting a constant-speed injection micropump to a controller;
5) Tearing off the protective sleeve 7, embedding the carotid artery implantation device into the wall of the carotid artery vessel, and penetrating the needle 5 with the obtuse angle of 135 degrees through the sealing plug 3 and deep into the carotid artery implantation catheter 1; then the needle tip is exposed by penetrating the sealing cover 2;
6) Puncturing the wall of the carotid artery blood vessel by using the needle point, and immediately retracting the needle point back into the carotid artery for implantation in the catheter 1;
7) The injection speed is set through a controller, a constant-speed injection micro pump is controlled to drive a propeller, a piston handle of the injector 6 is pushed, an injection is injected into the common carotid artery implantation catheter 1 through a needle 5, and a unidirectional flow gate is flushed through an injection opening to flow out;
8) After the injection is finished, the common carotid artery implanted catheter 1 is under negative pressure, and the unidirectional flow gate is closed;
9) After the operation is finished, the common carotid artery implantation device is taken out.
Finally, it should be noted that the examples are disclosed for the purpose of aiding in the further understanding of the present invention, but those skilled in the art will appreciate that: various alternatives and modifications are possible without departing from the spirit and scope of the invention and the appended claims. Therefore, the invention should not be limited to the disclosed embodiments, but rather the scope of the invention is defined by the appended claims.
Claims (6)
1. An implantable internal carotid artery constant-speed injection device, comprising: the common carotid artery implantation catheter, the sealing cover, the sealing plug, the injection opening, the unidirectional flow gate, the marker, the needle, the injector, the propeller, the constant-speed injection micro pump and the controller; wherein, the common carotid artery implantation catheter is a cylindrical hollow catheter with hollow inside; the top end of the carotid artery implanted catheter is provided with a sealing cover, and the rear end is provided with a sealing plug; an injection opening is arranged on the side wall of the front end of the carotid artery implantation catheter; a unidirectional flow gate is arranged at the injection opening and positioned outside the carotid artery implantation catheter and covers the injection opening, the front end of the unidirectional flow gate is connected to the side wall of the front end of the carotid artery implantation catheter, and the unidirectional flow gate can be opened and closed outside the carotid artery implantation catheter around the connection position; a marker is arranged at the front end of the common carotid artery implantation catheter; the common carotid artery implantation catheter, the sealing cover, the sealing plug, the injection opening, the unidirectional flow gate and the marker form a common carotid artery implantation device; the front end of the injector is connected with a needle head, the shape of the needle head is a folded line type with an obtuse angle, and the obtuse angle of the needle head is 120-145 degrees; the needle penetrates the sealing plug and goes deep into the carotid artery implantation catheter; the piston handle at the bottom end of the injector is connected to the propeller; the propeller is connected to a constant-speed injection micro pump; the constant-speed injection micropump is connected to the controller; embedding the common carotid artery implant device into the wall of the common carotid artery vessel, penetrating the needle head through the sealing plug and deep into the common carotid artery implant catheter, and penetrating the sealing cover to expose the needle point; puncturing the wall of the carotid artery vessel by using the needle point, and immediately returning the needle point to the carotid artery for implantation in the catheter; setting the injection rate through a controller, controlling a constant-speed injection micro pump to drive a propeller, pushing a piston handle of the injector, and injecting the injection into the common carotid artery implantation catheter through a needle; the empty cylinder of the injector is filled with the injection, the injection rate is set by the controller, the constant-speed injection micro pump is controlled to drive the propeller, the piston handle of the injector is pushed, the injection is injected into the carotid artery implantation catheter through the needle, and the injection flows out through the injection opening and the one-way flow gate; after the injection is finished, the pressure of the blood reflux is higher than the pressure in the carotid artery implanted catheter, namely the carotid artery implanted catheter is negative pressure, and the unidirectional flow gate is closed; the device also comprises a protective sleeve which is sleeved outside the common carotid artery implantation device.
2. The constant velocity injection device of claim 1, wherein the common carotid artery implant catheter is polyvinyl chloride PVC, polyethylene PE or polystyrene PS; the internal diameter of the common carotid artery implantation catheter is 0.5-0.75 mm; the outer diameter is 1-1.25 mm.
3. The constant velocity injection device of claim 1, wherein the sealing cap and sealing plug are made of one of rubber, latex and silicone.
4. The constant velocity injection device of claim 1, wherein the injection opening has a diameter of 1 to 2mm and a distance of 3 to 4mm from the tip of the common carotid artery implantation catheter.
5. The constant velocity injection device of claim 1, wherein the marker employs an indicator strip, the indicator strip surface being coated with a fluorescent agent; the indicator strip is tightly adhered to the inner surface of the sealing cover.
6. The constant velocity injection device of claim 1, wherein the controller comprises a power source, an input device, an output device, and a control circuit board; wherein, the power supply is respectively connected to the input device, the output device and the control circuit board; the control circuit board is respectively connected to the input device and the output device; the infusion rate and injection time are set by the input device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910021986.3A CN109481070B (en) | 2019-01-10 | 2019-01-10 | Implantable internal carotid artery constant-speed injection device and operation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910021986.3A CN109481070B (en) | 2019-01-10 | 2019-01-10 | Implantable internal carotid artery constant-speed injection device and operation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109481070A CN109481070A (en) | 2019-03-19 |
| CN109481070B true CN109481070B (en) | 2023-04-25 |
Family
ID=65714364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910021986.3A Active CN109481070B (en) | 2019-01-10 | 2019-01-10 | Implantable internal carotid artery constant-speed injection device and operation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109481070B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112121253A (en) * | 2020-10-10 | 2020-12-25 | 南通伊诺精密塑胶导管有限公司 | Radiography catheter |
| CN113521489A (en) * | 2020-11-20 | 2021-10-22 | 首都医科大学 | Small animal drainage and administration device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2325829A1 (en) * | 1995-02-17 | 1996-08-22 | Alan K. Plyley | Implantable access device |
| CN2258773Y (en) * | 1996-07-19 | 1997-08-06 | 李景荣 | One-way valve for anticounterflow of blood for full imbedding type medicine imput pump |
| US6053901A (en) * | 1994-01-18 | 2000-04-25 | Vasca, Inc. | Subcutaneously implanted cannula and method for arterial access |
| US6120492A (en) * | 1997-07-18 | 2000-09-19 | Vasca, Inc. | Method and apparatus for percutaneously accessing an implanted port |
| US6471689B1 (en) * | 1999-08-16 | 2002-10-29 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
| CN104684600A (en) * | 2012-07-26 | 2015-06-03 | 新加坡科技研究局 | Vascular access device and guiding portion |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015364276B2 (en) * | 2014-12-18 | 2020-04-30 | Versago Vascular Access, Inc. | Devices, systems and methods for removal and replacement of a catheter for an implanted access port |
-
2019
- 2019-01-10 CN CN201910021986.3A patent/CN109481070B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6053901A (en) * | 1994-01-18 | 2000-04-25 | Vasca, Inc. | Subcutaneously implanted cannula and method for arterial access |
| CA2325829A1 (en) * | 1995-02-17 | 1996-08-22 | Alan K. Plyley | Implantable access device |
| CN2258773Y (en) * | 1996-07-19 | 1997-08-06 | 李景荣 | One-way valve for anticounterflow of blood for full imbedding type medicine imput pump |
| US6120492A (en) * | 1997-07-18 | 2000-09-19 | Vasca, Inc. | Method and apparatus for percutaneously accessing an implanted port |
| US6471689B1 (en) * | 1999-08-16 | 2002-10-29 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
| CN104684600A (en) * | 2012-07-26 | 2015-06-03 | 新加坡科技研究局 | Vascular access device and guiding portion |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109481070A (en) | 2019-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7534233B2 (en) | Flush syringe having anti-reflux features | |
| CN109481070B (en) | Implantable internal carotid artery constant-speed injection device and operation method thereof | |
| NO338123B1 (en) | Flush syringe with anti-flashback straps | |
| NO334969B1 (en) | Rinse syringe with anti-flashback insert | |
| CN212788638U (en) | Nerve stimulation needle beneficial to ultrasonic guidance | |
| CN109316352B (en) | Automatic liquid medicine adding injection bottle device and production device and assembly production method thereof | |
| CN211356032U (en) | Common carotid artery implantation device and implantable internal carotid artery constant-speed injection device | |
| CN103691033A (en) | Puncture needle for brachial plexus block | |
| CN207734452U (en) | A kind of implantable drug delivery system | |
| CN213252065U (en) | Disposable special syringe for chemotherapy medicine | |
| CN103691037B (en) | Improved remote injection device | |
| CN111529196A (en) | Injection flow adjustable double-chamber injector for eye | |
| CN209203489U (en) | Bone cement directional injector | |
| CN208822920U (en) | It is a kind of through vena jugularis externa row deep venouspuncture | |
| CN208229118U (en) | A kind of quick medicine-feeding device of psychiatric department | |
| CN206261903U (en) | A kind of syringe | |
| CN209004903U (en) | A kind of dedicated pre-encapsulated injector of subcutaneous injection | |
| CN209360974U (en) | A kind of fixation device for experimental mouse heart perfusion | |
| CN212281872U (en) | Injection flow adjustable double-chamber injector for eye | |
| CN202143734U (en) | Disposable remaining needle tube sealing device with tube sealing solution | |
| CN220046179U (en) | Injection device | |
| CN208145042U (en) | Microinjection apparatus with piston | |
| CN203059875U (en) | Bone expansion device | |
| CN220572482U (en) | Injector for mixing particles and liquid | |
| CN209679151U (en) | A kind of enteroclysm device with intubation auxiliary device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |