CN109480803A - Integrate the bio-compatible micro device of sensor and drug holding theca - Google Patents
Integrate the bio-compatible micro device of sensor and drug holding theca Download PDFInfo
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- CN109480803A CN109480803A CN201910002432.9A CN201910002432A CN109480803A CN 109480803 A CN109480803 A CN 109480803A CN 201910002432 A CN201910002432 A CN 201910002432A CN 109480803 A CN109480803 A CN 109480803A
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- drug holding
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- holding theca
- sensor
- pressure sensor
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- 239000003814 drug Substances 0.000 title claims abstract description 81
- 229940079593 drug Drugs 0.000 title claims abstract description 67
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960002897 heparin Drugs 0.000 claims abstract description 12
- 229920000669 heparin Polymers 0.000 claims abstract description 12
- 238000013268 sustained release Methods 0.000 claims abstract description 11
- 239000012730 sustained-release form Substances 0.000 claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims abstract description 9
- 241000252492 Astyanax Species 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 210000002615 epidermis Anatomy 0.000 claims description 3
- 210000005036 nerve Anatomy 0.000 claims description 2
- 208000007536 Thrombosis Diseases 0.000 abstract description 42
- 210000004369 blood Anatomy 0.000 abstract description 23
- 239000008280 blood Substances 0.000 abstract description 23
- 238000012544 monitoring process Methods 0.000 abstract description 12
- 230000008901 benefit Effects 0.000 abstract description 5
- 238000001514 detection method Methods 0.000 abstract description 4
- 238000002513 implantation Methods 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 description 20
- 210000004204 blood vessel Anatomy 0.000 description 16
- 230000000694 effects Effects 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000012530 fluid Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000002775 capsule Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 239000003146 anticoagulant agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 230000002459 sustained effect Effects 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 230000002537 thrombolytic effect Effects 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 238000003911 water pollution Methods 0.000 description 4
- 229940127219 anticoagulant drug Drugs 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003527 fibrinolytic agent Substances 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- 208000000575 Arteriosclerosis Obliterans Diseases 0.000 description 2
- 206010014513 Embolism arterial Diseases 0.000 description 2
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005067 remediation Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 206010003178 Arterial thrombosis Diseases 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010050902 Postoperative thrombosis Diseases 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6876—Blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Physiology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a kind of bio-compatible micro devices for integrating sensor and drug holding theca, which is characterized in that the bio-compatible micro device includes pressure sensor；The pressure sensor forms an oval drug holding theca by the polymer wrapped with bio-compatibility；Two sides are equipped with sensor flexibility feeler lever to the drug holding theca leading portion up and down；Two sides are equipped with tube wall stay hook up and down in the middle part of the drug holding theca；Two sides are equipped with heparin sustained release channel to the drug holding theca back segment up and down；The sensor flexibility feeler lever is connected with pressure sensor body；The heparin sustained release channel is communicated with drug holding theca.Its advantage is shown: facilitating implantation target blood section, by in art, the real-time monitoring of rear blood stream pressure, according to the variation of blood stream pressure, real-time early warning is implemented to thrombosis, by easily formed thrombus dispose into system, easily form the phase in thrombus, pass through the detection to blood stream pressure, the slow release for realizing medicine for treating thrombus object, reaches anti-bolt purpose.
Description
Technical field
The present invention relates to drug loaded device technical fields, specifically, being a kind of life for integrating sensor and drug holding theca
Object is compatible with micro device.
Background technique
With the raising of aging of population and living standards of the people, arteriosclerosis obliterans (arteriosclerosis
Obliterans, ASO) disease incidence no matter be all in raised state year by year in western countries or in China.According to the literature,
The amputation rate of ASO is 15.3%, and the death rate 3.6% causes strong influence to the quality of life of patient.Currently, counterweight
The treatment method of disease ASO includes traditional operation and Endovascular Therapy, however, either traditional operation or Endovascular is controlled
It treats, postoperative high concurrent disease rate, which becomes to restrict, treats successful principal element.Foreign literature report, after ASO surgical intervention, lumen of vessels
The incidence of interior Arterial thrombosis and arterial embolism is respectively 7% and 5%, is postoperative most important complication.Thus, it can
The key factor for determining treatment success or failure will be become by solving the postoperative thrombosis of ASO and arterial embolism.It is main at present for postoperative anti-bolt
The mode to be used is the use of whole body anticoagulant or the local administration by way of intervention.Intravascular regional flow's pressure becomes
The reason of change is to judge thrombosis important evidence, thrombosis includes blood change, vascular injury and stasis of blood stream.And blood flow
Slow and be retarded by silt even more thrombosis important mechanisms.When the reasons such as post-surgical vascular form cause blood flow disorder to cause whirlpool
When stream, so that haemocyte residence time in being vortexed is long, thrombosis will be promoted.Hemodynamic effects are divided according to thrombus
Analysis and computational fluid dynamics simulation show that thrombus can cause serious shadow to the hemodynamic parameter of targeting blood circulation system
It rings, blood stream is reduced through pressure when thrombus section, flow velocity and boundary shear stress increase, and the resistance of blood flow increases, and blood flow can go out
Existing: speed slows down, barometric gradient reduces, the distribution of boundary shear stress is more uniform, to will lead to targeting blood circulation system
The blood supply ability of system declines, and increases around thrombus with a possibility that corresponding intravascular formation new thrombus.In recent years, at easy bolt
The superiority of the positioning anti-bolt of sustained drug has been known together, the thrombotic disease in the 9th edition ACCP clinical practice guideline
Antithrombotic treatments recommend low molecular weight heparin to treat and prevent thrombus (recommendation rank: 1B grades), and suggest the use of anticoagulant
Total course for the treatment of is at least 3 months, better than shorter treatment time (recommendation rank: 2C grades).Meanwhile lot of documents shows local thrombolysis
Curative effect be better than whole body thrombolysis.It is obvious for positioning the superiority of the anti-bolt of sustained drug at easy bolt.
The sustained release of drug is after (or compound, packing), to throw in conjunction with macromolecule carrier and be applied to biology pharmaceutical activity molecule
It is released again with concentration appropriate and duration in active body by control modes, pharmaceutical activity molecules such as diffusion, infiltrations,
To achieve the purpose that give full play to curative effect of medication.Different by its biodegradability can be divided into Biodegradable and Fei Sheng again
Two class of object degradation-type.Diffusion of the drug in polymer support can pass through two Basic Ways: (1) directly non-by polymer
Crystalline region；(2) it is diffused by the hole of polymeric inner.Formulations for systemic administration or predominantly drug agent the shortcomings that insertion administration at present
Amount is big, is easy to appear the side effects such as blood.Can not real-time detection artery local pressure, drug launch not in time.
In recent years micro- based on MEMS (Micro-Electronic-Mechanic-System microelectromechanical systems) technology
Type pressure sensor is gradually applied in clinical medicine.MEMS pressure sensor be using single crystal silicon material piezoresistive effect and
Sensor made of integrated circuit technique.Circular silicon membrane piece surrounding is fixed with circle silicon ring, one section of diaphragm and tested pressure system phase
Even, the other side is set as vacuum or an atmosphere as reference.After the effect being under pressure, integrated circuit technology method is utilized
The resistivity for spreading the equal p-type resistance of four resistance values changes, and can just obtain being proportional to pressure by bridge measuring circuit
The electric signal output of power variation.
Chinese patent literature: CN201720410999.6, applying date 2017.04.19, patent name are as follows: one kind is for controlling
Manage the micro device of deep water pollution.It discloses a kind of for administering the micro device of deep water pollution, including elliposoidal
Shell, shell is made of upper and lower casing, be equipped at shell both ends into and out of water hole, in addition, inside housings, upper-lower casing group
The mutual split of part goes out left and right partition, water inlet pipe and outlet pipe, and shell chamber is divided into reaction driving pond by left and right partition, bacterium carries medicine
Pond and magnetic force are oriented to three, pond workspace.It has following advantage: 1, device can be free to move to deep contaminant water in water body
Domain, and static in the region and degrade to pollutant, efficiently solve water remediation agent be difficult to purify deep water body it is dirty
The problem of dye.2, B. subtilis strain, combination drive agent and Organic-soluble resin, device after being tamed by application have intelligence
The excellent properties such as energy targeting, efficient degradation and economic and environment-friendly property.3, according to magnetic force guiding principle, device directional movable is extremely
Polluted water region effectively increases the job stability of utility model.
A kind of Chinese patent literature: CN201720436217.6, applying date 2017.04.24, patent name are as follows: load medicine glue
Capsule prepares spray head and medicine-carrying capsule preparation facilities, and it includes: the interior needle for flowing out for internal layer medical fluid which, which prepares spray head,；
Outer needle for going out for outer layer covers liquid stream, outer needle are coated at interior needle；Shell is prepared with tap and air inlet；The needle of interior needle
The pin hole of hole and outer needle, which is respectively positioned on, to be prepared in shell, air inlet be used to lead to air-flow at the pin hole of interior needle and at the pin hole of outer needle with
Internal layer medical fluid and outer layer covers liquid is set to form the jet stream that can be broken for drop, tap is located at bottom end and the use of interior needle and outer needle
In for being projected by jet stream.Medicine-carrying capsule disclosed in the utility model prepares spray head, utilizes the outer layer covers liquid packet flowed out from outer needle
Wrap up in the internal layer medical fluid flowed out from interior needle；The outer layer covers liquid of outflow and internal layer medical fluid is set to form jet stream, jet surface using air-flow
Upper disturbance constantly increases, and eventually leading to jet crushing is drop, which effectively reduces medicine-carrying capsule
Volume facilitates patients.
One of above patent document CN201720410999.6 is used to administer the micro device of deep water pollution, can
It is free to move to deep polluted water region in water body, and static in the region and degrade to pollutant, efficiently solves
Water remediation agent is difficult to the problem of purifying deep water pollution；And one of patent document CN201720436217.6 carries medicine glue
Capsule prepares spray head and medicine-carrying capsule preparation facilities utilizes the outer layer covers liquid flowed out from outer needle to wrap up the internal layer medicine flowed out from interior needle
Liquid；The outer layer covers liquid of outflow and internal layer medical fluid is set to form jet stream using air-flow, disturbance constantly increases on jet surface, finally leads
Cause jet crushing is drop, which effectively reduces the volume of medicine-carrying capsule, facilitate patients.But
Be about it is a kind of facilitate implantation target blood section, by art, the real-time monitoring of rear blood stream pressure, according to the change of blood stream pressure
Change, to thrombosis implement real-time early warning, by easily formed thrombus dispose into system, the phase is easily formed in thrombus, by right
The slow release of medicine for treating thrombus object is realized in the detection of blood stream pressure, and a kind of collection sensor and drug holding theca for reaching anti-bolt purpose are one
The bio-compatible micro device of body is at present then without relevant report.
In conclusion need it is a kind of facilitate implantation target blood section, by art, the real-time monitoring of rear blood stream pressure, root
According to the variation of blood stream pressure, real-time early warning is implemented to thrombosis, by easily formed thrombus dispose into system, it is easy in thrombus
The formation phase realizes the slow release of medicine for treating thrombus object, reaches a kind of collection sensor of anti-bolt purpose by the detection to blood stream pressure
The bio-compatible micro device being integrated with drug holding theca.
Summary of the invention
The purpose of the present invention is aiming at the shortcomings in the prior art, providing a kind of facilitate to be implanted into target blood section, pass through art
In, the real-time monitoring of rear blood stream pressure real-time early warning implemented to thrombosis, by easy shape according to the variation of blood stream pressure
At thrombus dispose into system, easily form the phase in thrombus, by the detection to blood stream pressure, realize slowly releasing for medicine for treating thrombus object
It puts, reaches a kind of bio-compatible micro device for integrating sensor and drug holding theca of anti-bolt purpose.
To achieve the above object, the technical solution adopted by the present invention is that:
A kind of bio-compatible micro device integrating sensor and drug holding theca, which is characterized in that the biology is simultaneous
Holding micro device includes pressure sensor；The pressure sensor forms one by the polymer wrapped with bio-compatibility
The drug holding theca of ellipse；Two sides are equipped with sensor flexibility feeler lever to the drug holding theca leading portion up and down；On in the middle part of the drug holding theca
Lower two sides are equipped with tube wall stay hook；Two sides are equipped with heparin sustained release channel to the drug holding theca back segment up and down；The drug holding theca head
End is additionally provided with lead, and tail end is connected with circuit lead；The sensor flexibility feeler lever is connected with pressure sensor body；It is described
Heparin sustained release channel communicated with drug holding theca.
As a kind of perferred technical scheme, the pressure sensor be piezoresistive pressure sensor, cross section be 0~
500 microns.
As a kind of perferred technical scheme, the circuit lead length is greater than 40cm.
As a kind of perferred technical scheme, the pressure sensor and the bionical Mexico's Astyanax epidermis mind of drug holding theca
Through sense of touch principle.
As a kind of perferred technical scheme, the external pressure display equipment of the circuit lead and alarm.
The invention has the advantages that:
It 1, is piezoresistive pressure sensor using pressure sensor, it is small in size, be conducive to the method by performing the operation or intervening
It is put into blood vessel real-time monitoring blood stream pressure, to judge whether thrombus forms according to intravascular regional flow's pressure change.
2, pressure sensor outer surface is wrapped up using the polymer of bio-compatibility, can be placed in this micro device
In period in blood vessel, blood flow is not influenced.
3, the sensor flexibility feeler lever being equipped with using two sides above and below drug holding theca leading portion is eliminated rigid feeler lever and made in a fluid
At generation " vortex street effect " ensure simultaneously to can accurately measure endovascular minute-pressure and micrometeor using pressure sensor
Sensor does not have an impact intravascular blood flow.
4, the tube wall stay hook of two sides is used in device merging blood vessel behind corresponding position up and down in the middle part of drug holding theca, benefit
It is fixed with tube wall stay hook with vascular wall, thus the stabilization of holding meanss, so that it is guaranteed that pressure sensor pressure monitoring is accurate
Property.
5, different by the extruding degree of blood flow in the blood vessels by drug holding theca, that is, pressure sensor, thus by after drug holding theca
The medicine for treating thrombus object of the section heparin sustained release channel release various concentration that two sides are equipped with up and down.
6, thrombus, clinician switch to thrombolysis catheter at the first time and treat once being formed, and can be extensive according to blood flow
Multiple situation accurately controls dosage, as far as possible damage of the reduction Thrombolytic Drugs to other organs.
Detailed description of the invention
Attached drawing 1 is a kind of schematic diagram for the bio-compatible micro device for integrating sensor and drug holding theca of the present invention.
Attached drawing 2 is the structural schematic diagram of bionic intelligence sensor.
Attached drawing 3 is the schematic diagram of another bio-compatible micro device for integrating sensor and drug holding theca of the invention
Specific embodiment
It elaborates with reference to the accompanying drawing to specific embodiment provided by the invention.
Appended drawing reference involved in attached drawing and component part are as follows:
1. 11. sensor flexibility feeler lever of pressure sensor
2. 21. tube wall stay hook of drug holding theca
22. heparin is sustained 23. lead of channel
24. 25. through-hole of circuit lead
Embodiment 1
Attached drawing 1 is please referred to, Fig. 1 is a kind of bio-compatible micro device for integrating sensor and drug holding theca of the present invention
Schematic diagram.A kind of bio-compatible micro device integrating sensor and drug holding theca, the bio-compatible micro device packet
Include pressure sensor 1；The pressure sensor 1 forms an oval load by the polymer wrapped with bio-compatibility
Anther sac 2；Two sides are equipped with sensor flexibility feeler lever 11 to 2 leading portion of drug holding theca up and down；Two sides above and below 2 middle part of drug holding theca
Equipped with tube wall stay hook 21；Two sides are equipped with heparin sustained release channel 22 to 2 back segment of drug holding theca up and down；The drug holding theca 2
End is additionally provided with lead 23, and tail end is connected with circuit lead 24；The sensor flexibility feeler lever 11 and 1 ontology phase of pressure sensor
Even；The heparin sustained release channel 22 is communicated with drug holding theca 2.
It should be understood that the pressure sensor 1 is piezoresistive pressure sensor, and it is small in size, it can accomplish transversal
Face is no more than 500 microns, is conducive to be put into blood vessel real-time monitoring blood stream pressure by the method performed the operation or intervened, thus root
Judge whether thrombus forms according to intravascular regional flow's pressure change；1 outer surface of pressure sensor utilizes bio-compatible
Property polymer wrapped up, can be placed in period in the blood vessel (2 weeks or so) in this micro device, not influence blood flow；Institute
The pressure sensor 1 and the bionical Mexico's Astyanax epidermis nerve sense of touch principle of drug holding theca 2 stated, on the one hand, using before drug holding theca 2
Generation " vortex street effect " caused by the section sensor flexibility feeler lever 11 that two sides are equipped with up and down eliminates rigid feeler lever in a fluid, from
And endovascular minute-pressure and micrometeor can be accurately measured using pressure sensor 1, while ensuring sensor not to intravascular blood flow
It has an impact；On the other hand, set on 2 middle part of drug holding theca, the tube wall stay hook 21 of two sides is used to be placed in phase in blood vessel in device up and down
After answering position, fixed using tube wall stay hook 21 with vascular wall, thus the stabilization of holding meanss, so that it is guaranteed that pressure sensor 1
The accuracy of pressure monitoring；It finally, is that pressure sensor 1 is different by the extruding degree of blood flow in the blood vessels by drug holding theca 2, from
And the medicine for treating thrombus object that channel 22 discharges various concentration is sustained by 2 back segment of the drug holding theca heparin that two sides are equipped with up and down；It is described
Device be placed in blood vessel in time in, can monitoring objective blood vessel inner membrance reparation and thrombosis situation, pass through local targeting
It is anticoagulant, to reduce the use of anticoagulation；The lead 23 set on 2 front end of drug holding theca plays the role of guidance；Described
Circuit lead 24 set on 2 tail end of drug holding theca is connected with 1 ontology of pressure sensor, and at least 40cm of the circuit lead 24, and
Diameter is thinner, can be through in external seal wire, thus when in device merging blood vessel, by the way that circuit lead 24 is passed through seal wire, benefit
With seal wire seal wire will be withdrawn from after device is placed in blood vessel designated position, and external circuit lead 24 then external corresponding pressure
Power shows equipment and alarm etc., can set the threshold that pressure sensor monitors blood stream pressure using pressure display equipment
Value, and is connected to alarm simultaneously and alarms, so that during monitoring, the pressure that is measured by pressure sensor 1
Changing (in given threshold), control drug holding theca 2 releases the medicine for treating thrombus object of various concentration, to achieve the purpose that the anti-bolt in part,
The pressure value measured such as pressure sensor 1 is more than the threshold value that some sets, then illustrates that device set-down location has thrombosis, and same
When set out alarm, at this point, clinician switchs to thrombolysis catheter at the first time carries out treatment to thrombus, and can be extensive according to blood flow
Multiple situation, accurately controls dosage, and damage of the reduction Thrombolytic Drugs to other organs as far as possible is asked to fundamentally solve thrombus
Topic.
Embodiment 2
Please refer to attached drawing 3, Fig. 3, which is that the present invention is a kind of, integrates sensor and the bio-compatible micro device of drug holding theca is another
A kind of structural schematic diagram.The present embodiment is substantially the same manner as Example 1, the difference is that, the apparatus surface in the present embodiment
I.e. 2 surface of drug holding theca is equipped with multiple through-holes 25；The utilization is equipped with multiple through-holes 25 on 2 surface of drug holding theca, then can be in device
After the pressure for receiving blood flow, so that the range that the medicine for treating thrombus in drug holding theca 2 discharges is wider, so that the treatment of thrombus be effectively ensured
Effect.
A kind of bio-compatible micro device integrating sensor and drug holding theca of the invention is using pressure sensor
Piezoresistive pressure sensor, it is small in size, be conducive to be put into blood vessel real-time monitoring blood flow pressure by the method performed the operation or intervened
Power, to judge whether thrombus forms according to intravascular regional flow's pressure change；Pressure sensor outer surface is simultaneous using biology
The polymer of capacitive is wrapped up, and can not influence blood flow within the period that this micro device places in the blood vessel；Utilize drug holding theca
Generation " vortex street effect " caused by the leading portion sensor flexibility feeler lever that two sides are equipped with up and down eliminates rigid feeler lever in a fluid, from
And endovascular minute-pressure and micrometeor can be accurately measured using pressure sensor, while ensuring that sensor does not produce intravascular blood flow
It is raw to influence；The tube wall stay hook of two sides is used in device merging blood vessel behind corresponding position up and down in the middle part of drug holding theca, is utilized
Tube wall stay hook is fixed with vascular wall, thus the stabilization of holding meanss, so that it is guaranteed that the accuracy of pressure sensor pressure monitoring；
It is different by the extruding degree of blood flow in the blood vessels by drug holding theca, that is, pressure sensor, to pass through two sides above and below drug holding theca back segment
The medicine for treating thrombus object for the heparin sustained release channel release various concentration being equipped with；Thrombus once being formed, clinician switch to molten at the first time
Bolt conduit is treated, and can accurately control dosage according to restoration of blood flow situation, and reduction Thrombolytic Drugs as far as possible are to other devices
The damage of official.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, under the premise of not departing from the method for the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (5)
1. a kind of bio-compatible micro device for integrating sensor and drug holding theca, which is characterized in that the bio-compatible
Micro device includes pressure sensor；The pressure sensor is ellipse by the polymer wrapped formation one with bio-compatibility
Circular drug holding theca；Two sides are equipped with sensor flexibility feeler lever to the drug holding theca leading portion up and down；In the middle part of the drug holding theca up and down
Two sides are equipped with tube wall stay hook；Two sides are equipped with heparin sustained release channel to the drug holding theca back segment up and down；The drug holding theca head end
It is additionally provided with lead, tail end is connected with circuit lead；The sensor flexibility feeler lever is connected with pressure sensor body；Described
Heparin sustained release channel is communicated with drug holding theca.
2. bio-compatible micro device according to claim 1, which is characterized in that the pressure sensor is pressure resistance type
Pressure sensor, cross section are 0~500 micron.
3. bio-compatible micro device according to claim 1, which is characterized in that the circuit lead length is greater than
40cm。
4. bio-compatible micro device according to claim 1, which is characterized in that the pressure sensor and drug holding theca
Bionical Mexico's Astyanax epidermis nerve sense of touch principle.
5. bio-compatible micro device according to claim 1, which is characterized in that the external pressure of the circuit lead is aobvious
Show equipment and alarm.
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| CN201910002432.9A CN109480803A (en) | 2019-01-02 | 2019-01-02 | Integrate the bio-compatible micro device of sensor and drug holding theca |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910002432.9A CN109480803A (en) | 2019-01-02 | 2019-01-02 | Integrate the bio-compatible micro device of sensor and drug holding theca |
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Cited By (1)
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| WO2022199198A1 (en) * | 2021-03-23 | 2022-09-29 | 谈斯聪 | Intravascular nano robot apparatus, optimized control system, and method |
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