CN109456381A - A kind of preparation method of Delmadinone - Google Patents
A kind of preparation method of Delmadinone Download PDFInfo
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- CN109456381A CN109456381A CN201811550148.7A CN201811550148A CN109456381A CN 109456381 A CN109456381 A CN 109456381A CN 201811550148 A CN201811550148 A CN 201811550148A CN 109456381 A CN109456381 A CN 109456381A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
Abstract
The present invention provides a kind of preparation method of Delmadinone, the method includes using 1,4- androsadiendione, that is, IDD is raw material, 17 in IDD molecule ketone are made to react under base catalysis in the first organic solvent with acetone cyanohydrin first, in 17 introducing beta-hydroxies and alpha-cyano, hydroxyl cyanogen object is obtained；Then by hydroxyl cyanogen object in the presence of methyl-magnesium-halide, the second organic solvent and acid, the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- are prepared；6 epoxy materials are synthesized again, are synthesized 6 chlorides thereafter and are obtained the Delmadinone.The plurality of advantages such as prior synthesizing method of the method for the present invention relative to Delmadinone and delmadinone acetate has technological operation easy, and production economy is environmentally friendly, and synthesis total recovery is high, good product quality, and production cost is low.
Description
Technical field
The invention belongs to the preparation processes of steroid hormone drug, and in particular to arrive a kind of progestational hormone medicine Delmadinone acetic acid
The preparation method of ester and its intermediate Delmadinone.
Background technique
Delmadinone acetate, chemical name are as follows: the pregnant steroid-Isosorbide-5-Nitrae of the chloro- 17a- acetoxyl group-of 6-, 6-, triolefin -3,20- diketone,
It is a kind of efficient progestational hormone medicine, there is stronger decorporation cream effect, be clinically mainly used for the unsmooth fertility women of milk ejection and exist
Promote milk ejection during lactation.It is in ox, sheep cultivation for promoting milk cow, milch goat milk ejection that it, which is applied at most, since effect is good,
Side effect is low, and market application prospect is wide.The conventional production methods of delmadinone acetate are with 17a hydroxyl progesterone for original
Material, through acetic anhydride diacetyl, bleaching powder chlorination, triethyl orthoformate etherificate, the four-step reactions such as DDQ (or tetrachloroquinone) dehydrogenation
Serine progesterone acetate is first made, then on this basis with DDQ in 1 dehydrogenation, delmadinone acetate, synthetic route is made
See attached drawing 1.The method is when preparing serine progesterone acetate, anti-with chlorination using diacetyl using 17a- hydroxyl progesterone as raw material
It should treat different things alike, it is easy to operate, but impurity is more, purity difference.Etherificate and dehydrogenation reaction, it is molten that Shanghai Hua Lian pharmaceutical purpose benzene does etherification reaction
Agent makees dehydrogenation reaction reagent with DDQ, toxic, and environmental protection is difficult to handle.Using low-temperature dehydrogenation technique, in addition intermediate purity difference,
Cause that product purity is low, there are many impurity, and column chromatography is needed could to purify, and synthesize weight total recovery and there was only 27%, cost is very high.Lake
Northern institute of Pharmaceutical Industry makees solvent using technique etherificate and the dehydrogenation for the treatment of different things alike with chloroform, monoethyl quinone does dehydrogenating agent, avoids
Toxic benzene and DDQ are used, synthesis weight total recovery has been increased to 48%, but to use a large amount of chloroforms, and reaction impurities are more,
Want column chromatography that could purify.When finally preparing delmadinone acetate, using DDQ by serine progesterone acetate 1 in dioxane
Position dehydrogenation is made delmadinone acetate, and environmental protection is also difficult to handle, and it is more to have suffered in technique that there are side reactions, and impurity is more, product
Purity is low, and environmental protection treatment is difficult, the problems such as production cost height.
Therefore, this field needs a kind of new method for preparing delmadinone acetate and its intermediate Delmadinone.
Summary of the invention
Therefore, the present invention provides a kind of preparation method of Delmadinone, and the method includes using Isosorbide-5-Nitrae-androsadiendione
That is IDD is raw material, occurs that 17 ketone in IDD molecule under base catalysis in the first organic solvent with acetone cyanohydrin instead
It answers, in 17 introducing beta-hydroxies and alpha-cyano, obtains hydroxyl cyanogen object；Then by hydroxyl cyanogen object in methyl-magnesium-halide, the second organic solvent
In the presence of acid, the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- are prepared；6 epoxy materials are synthesized again, synthesize 6 chlorinations thereafter
Object obtains the Delmadinone.
In a kind of specific embodiment, first organic solvent is acetone cyanohydrin, methylene chloride, DME, acetic acid second
One or more of ester, THF and C4 or less low-carbon alcohols, preferably described first organic solvent are methanol.
In a kind of specific embodiment, the alkali is organic base or inorganic base, preferably pyridine, triethylamine, carbonic acid
One of sodium and sodium hydroxide are a variety of, more preferable sodium carbonate.
In a kind of specific embodiment, second organic solvent is in methylene chloride, toluene, ether and THF
One or more, preferably described second organic solvent are THF.
In a kind of specific embodiment, it is described acid be organic acid or inorganic acid, preferably acetic acid, p-methyl benzenesulfonic acid,
One of hydrochloric acid and sulfuric acid are a variety of, more preferable hydrochloric acid.
In a kind of specific embodiment, it is 10~100 DEG C that IDD, which reacts reaction temperature in the step of generating hydroxyl cyanogen object,
Reaction temperature is 30~100 DEG C in the step of reaction of hydroxyl cyanogen object generates 1,6- bis- dehydrogenation -17a- hydroxyl progesterones, and reaction process
In include first adding methyl-magnesium-halide into the second organic solvent and hydroxyl cyanogen object grignard addition reaction occurs, then add acid for grignard
The hydrolysis of grignard object that addition reaction obtains, be then recovered under reduced pressure organic solvent and plus water obtain after elutriation that 1, the 6- is bis- to be taken off
Hydrogen -17a- hydroxyl progesterone.
In a kind of specific embodiment, in the step of synthesizing 6 epoxy materials, including by the bis- dehydrogenation -17a- of 1,6-
Hydroxyl progesterone dissolves in third organic solvent, adds peroxy acid reaction that the epoxy material is prepared；Chlorine is being synthesized by epoxy material
In the step of compound, that is, Delmadinone, including epoxy material dissolved in the 4th organic solvent, hydrogen chloride gas reaction is added to be prepared into
To the Delmadinone.
In a kind of specific embodiment, the third organic solvent is selected from methanol, ethyl alcohol, DME, tetrahydrofuran, chlorine
One or both of imitative, ethyl acetate, the peroxy acid are Peracetic acid, in benzoyl hydroperoxide, adjacent benzoyl hydroperoxide acid anhydride
It is a kind of；4th organic solvent be selected from glacial acetic acid, C4 or less low-carbon alcohols, ether, DMF, DME, ethyl acetate, tetrahydrofuran,
One of dioxane.
In a kind of specific embodiment, the method also includes first using nutrient medium and one or more micro- lifes
Object strain makes phytosterol that Isosorbide-5-Nitrae-androsadiendione i.e. IDD be prepared after microbial fermentation.
It include glucose, corn pulp, inorganic salts, yeast in the nutrient medium in a kind of specific embodiment
One of cream, beef extract and peptone are a variety of, the microorganism fungus kind be include Mycobacterium, Fusarium reconciliation starch
One of bacillus is a variety of.
Present invention aim to address existing delmadinone acetate production present in side reaction it is more, impurity is more, product
Purity is low, and synthesis total recovery is low, and environmental protection treatment is difficult, many defects such as production cost height, provides a kind of new Delmadinone acetic acid
The preparation method of ester.
The object of the present invention is to provide a kind of preparation methods of delmadinone acetate, including first use IDD for raw material, warp
17 hydroxyl cyanidings, the two-step reactions such as 17 cyano grignard additions and sour water solution, synthesize the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6-,
Synthetic route is shown in Fig. 2.Obviously, which has many advantages such as that raw material sources are wide, technological operation is easy, production economy is environmentally friendly, gram
It is many not expensive synthesis material in above-mentioned traditional processing technology, complex operation, environmental protection treatment hardly possible, production cost height etc. have been taken
Foot.
In the present invention, the preparation method of 1,6- bis- dehydrogenation -17a- hydroxyl progesterones: (referred to as with Isosorbide-5-Nitrae-androsadiendione
IDD it is) starting material, issues 17 in IDD molecule ketone with acetone cyanohydrin in base catalysis in the first organic solvent
Raw addition reaction obtains hydroxyl cyanogen object in 17 introducing b hydroxyls and a cyano；Then by 17 a cyano in hydroxyl cyanogen object molecule,
Grignard addition reaction occurs with methyl-magnesium-halide Grignard Reagent in second organic solvent, introduces 21 methyl and 20 enamines, 17
Position hydroxyl changes into a by b, which does not need to be separated, and directly hydrolyzes 20 enamines in molecule under acid catalysis, just turns
20 ketone are turned to, so that 1 is obtained, the bis- dehydrogenation -17a- hydroxyl progesterones of 6-.
Further, the concrete operations synthesized are as follows:
A: the preparation of hydroxyl cyanogen object
Starting material IDD is dissolved in the first organic solvent, is stirred, acetone cyanohydrin is added to 10~100 DEG C in temperature control,
2% aqueous alkali is slowly added dropwise, drips off within about 2-2.5 hours, then keeps the temperature and is reacted 2~3 hours in 10~100 DEG C, TLC confirmation is anti-
Terminal is answered, after having reacted, divides water, is washed, recycling organic solvent, tap water elutriation, then with alcohol water is concentrated under reduced pressure in organic layer
Solution crystallization, obtains hydroxyl cyanogen object, 98.0% or more HPLC content, weight yield 95~100%.
The preparation of the bis- dehydrogenation -17a- hydroxyl progesterones of B:1,6-
Magnesium powder, organic solvent are added into reactor, stirred, temperature control is slowly passed through methyl halogenated alkane to 20~80 DEG C,
It is spare to obtain Grignard Reagent until magnesium powder completely disappears for reaction 4-6 hours；
Hydroxyl cyanogen object is dissolved in the second organic solvent, is stirred, above-mentioned get ready is slowly added dropwise to 30~100 DEG C in temperature control
Grignard Reagent, about 1-1.5 hour drip off, then keep the temperature and react 2~3 hours in 30~100 DEG C, and TLC confirms reaction end, have reacted
Afterwards, then slowly acid is added dropwise, in 30~100 DEG C heat preservation hydrolysis 2-3 hours, TLC confirmation reaction end is organic after having hydrolyzed
Recycling organic solvent is concentrated under reduced pressure in layer, and system residue cools to 10~30 DEG C, and tap water elutriation, filtering, filtrate is added
Environmental protection treatment pond is sent to handle after pretreatment；Filter cake washing, drying obtain the bis- dehydrogenation -17a- hydroxyl progesterone crude products of 1,6-, HPLC
97.0% or more content, weight yield 100~105%.Bis- dehydrogenation -17a- hydroxyl progesterone the crude products of above-mentioned 1,6- have been dissolved in
In solvent, active carbon is added, reflux decoloration 1-1.5 hours is filtered while hot, washes charcoal with suitable solvent, filter cake send producer to return
It receives, filtrate and washing lotion merge, and solvent is concentrated under reduced pressure to there is crystal precipitation, is subsequently cooled to -5~0 degree of crystallization 3-4 hours, filters,
Washing, drying, obtains the bis- dehydrogenation -17a- hydroxyl progesterone products of 1,6-, and 228~232 DEG C of fusing point, HPLC content 99.0-99.5%,
Disposing mother liquor is applied, this step weight total recovery 90-95%, synthesizes total recovery 86-90%.
The actual conditions of the bis- dehydrogenation -17a- hydroxyl progesterones of above-mentioned synthesis 1,6- are further described below again:
Above-mentioned synthesis A: the first organic solvent described in the preparation of hydroxyl cyanogen object, can be acetone cyanohydrin, methylene chloride, DME,
One or more of ethyl acetate, THF, C4 or less low-carbon alcohols etc.；Used in the aqueous alkali of synthesis catalyst 2% used
Alkali can be organic base such as pyridine, triethylamine etc., also optional inorganic base such as sodium carbonate, sodium hydroxide etc.；Synthesis reaction temperature 10
~100 DEG C；Depending on different reaction systems；Weight proportion between reactant is: IDD: acetone cyanohydrin: 2% buck=1g:
0.5~1.0g:1.5.0~3.0g；Proportion between reactant and solvent is: IDD: organic solvent=1g:2~12ml.
Second has described in Grignard Reagent synthesis in the preparation of the above-mentioned bis- dehydrogenation -17a- hydroxyl progesterones of synthesis B:1,6-
Solvent can be one or more of methylene chloride, toluene, ether, THF etc.；Methyl halogenated alkane can used in synthesis
To be chloromethanes, bromomethane or iodomethane；20~50 DEG C of above-mentioned Grignard reagent synthesis reaction temperature；Weight proportion between reactant
It is: magnesium: alkyl halide=1g:2.5~4.0g；Proportion between reactant and solvent is: magnesium: organic solvent=1g:2~12ml.
The organic solvent of the grignard reaction in the preparation of the bis- dehydrogenation -17a- hydroxyl progesterones of above-mentioned synthesis B:1,6-,
It can be one or more of toluene, benzene, chloroform, tetrahydrofuran, dioxane etc.；Hydrolysis acid used can be organic acid
Such as acetic acid, p-methyl benzenesulfonic acid, also optional inorganic acid such as hydrochloric acid, sulfuric acid etc.；The reaction temperature of grignard reaction and hydrolysis is
30~100 DEG C；Weight proportion between reactant is: IDD: grignard reagent solution=1g:5~15ml；Between reactant and solvent
Proportion is: IDD: reaction organic solvent=1g:2~10ml.
It is organic molten used in the product purification in the preparation of the above-mentioned bis- dehydrogenation -17a- hydroxyl progesterones of synthesis B:1,6-
Agent can be one or more of toluene, acetone, C4 or less low-carbon alcohols such as methanol, ethyl alcohol, isopropanol, the tert-butyl alcohol etc.；Purification
40~100 DEG C of temperature of control；The weight proportion of each storeroom is: crude product: active carbon=1g:0.03~0.10g；Crude product and solvent
Between proportion be crude product: organic solvent=1g:3-10ml.
Technical solution of the present invention further include: with the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- for raw material, first synthesize 6 rings
Oxygen object, secondary synthesizing chlorinated object, last 17-position ester three-step reaction synthesize delmadinone acetate, it may be assumed that
C, synthesizing epoxy object is to dissolve in 1,6- bis- dehydrogenation -17a- hydroxyl progesterones in third organic solvent, in molecule
6,7 double bonds reacted with peroxy acid, obtain epoxy material: 6 (7) a- epoxy -17a- hydroxyl -1- dehydrogenations-progesterone；
D, synthesizing chlorinated object is to dissolve in above-mentioned epoxy material in the 4th organic solvent, is then passed directly into hydrogen chloride gas,
In 6 introducing chlorine of epoxy material molecule, 7 introducing hydroxyls, in strong acid environment, dehydration then occurs for 7 hydroxyls, obtains chlorine
Compound: Delmadinone；
E, delmadinone acetate is synthesized, is to dissolve in above-mentioned gained Delmadinone in the 5th organic solvent, is urged in strong acid
Change lower and acetic anhydride and 17 acylation reactions occur, obtains delmadinone acetate.
Further, synthesis specific steps are as follows:
C, the synthesis of 6 epoxy materials
Bis- dehydrogenation -17a- the hydroxyl progesterones of 1,6- are dissolved in third organic solvent, peroxy acid is slowly added dropwise in 10-50 DEG C
The solution being made into organic solvent, about 1-1.5 hour add, then keep the temperature again continue to be stirred to react 12-16 in 10-50 DEG C it is small
When, TLC confirms reaction end, and after having reacted, suitable reducing agent is added to destroy remaining peroxy acid, is filtered to remove reaction life
At acid, then organic layer is washed 2 times with 10% sodium carbonate liquor again, further work-up obtains epoxy material: epoxy-
17a- hydroxyl -1- dehydrogenation-progesterone, HPLC content 98.0~99.0%, weight yield 90~95%；
D, the synthesis of chloride
Above-mentioned epoxy material is dissolved in organic solvent, temperature control is slowly passed through dry hydrogen chloride gas at 0-50 DEG C
In above-mentioned epoxy material solution, after 2-3 hours about logical, in 0~50 DEG C heat preservation confined reaction 8~16 hours, therebetween every 4 hours
Lead to 10 minutes hydrogen chloride gas, until TLC confirms fully reacting, after having reacted, it is molten that highly basic is slowly added dropwise in 1.0-1.5 hours
Liquid is neutralized to system pH6-7, then recycling organic solvent about 90-95% is concentrated under reduced pressure, and tap water, stirring and crystallizing 2-3 is then added
Hour, it filters, washes, it is dry, obtain chloride: Delmadinone, HPLC content 98-99.0%, this step reaction weight yield 100~
105%；
E, the synthesis of delmadinone acetate
Above-mentioned chloride object is dissolved in the 5th organic solvent, acetic anhydride is added, is added with stirring p-methyl benzenesulfonic acid class
Strong acid catalyst, then temperature control reacts 8~12 hours at 10~120 DEG C, and TLC confirms reaction end, after having reacted, is added suitable
Liquid adjusting PH with base 6.8-7.2 is measured, organic solvent is then recycled, cool down elutriation, obtains delmadinone acetate crude product, HPLC content
97.0-99.0%, weight yield 110-115%；Crude product is recrystallized with C4 or less low-carbon alcohols, obtains Delmadinone product, fusing point 206
~214 DEG C, HPLC content 99.0-99.5%, this step yield 90-95%；C~E three-step reaction synthesizes total recovery 85-90%.
Further, the reaction condition of above-mentioned synthesis delmadinone acetate is described as follows:
Organic solvent described in above-mentioned 6 epoxy materials synthesis is selected from methanol, ethyl alcohol, DME, tetrahydrofuran, chloroform, acetic acid second
One or both of ester；Peracetic acid, first benzoyl hydroperoxide, adjacent benzoyl hydroperoxide can be selected in peroxy acid used in epoxy reaction
One of acid anhydride etc.；Epoxy reactive reaction temperature is 10~50 DEG C；Weight proportion between reactant is 1,6- bis- dehydrogenations-
17a- hydroxyl-progesterone: peroxy acid=1g:0.4~0.6g；Proportion between reactant and solvent is 1,6- bis- dehydrogenation -17a- hydroxyls
Base-progesterone: organic solvent=1g:10~15ml；
Organic solvent described in above-mentioned chloride synthesis is selected from glacial acetic acid, C4 or less low-carbon alcohols, ether, DMF, DME, second
One of acetoacetic ester, tetrahydrofuran, dioxane etc.；Reaction temperature is 10~80 DEG C；Weight proportion between reactant is ring
Oxygen object: hydrogen chloride=1g:0.25~0.55g；Proportion between reactant and solvent is epoxy material: organic solvent=1g:10~
20ml；
Organic solvent described in the synthesis of above-mentioned delmadinone acetate be selected from toluene, chloroform, glacial acetic acid, dioxane,
One of DME, ethyl acetate etc.；10~80 DEG C of reaction temperature；Strong acid catalyst is selected from inorganic acids or the trifluoros such as hydrochloric acid, sulfuric acid
One of organic acids such as acetic acid, p-methyl benzenesulfonic acid；Weight proportion between reactant is chloride: acetic anhydride=1g:0.2~
0.6g；Proportion between reactant and solvent is chloride: organic solvent=1g:8-15ml.
The optimal conditions of above-mentioned synthesis delmadinone acetate are as follows:
Organic solvent ethyl acetate described in above-mentioned epoxy material synthesis；First mistake between oxidant used in epoxy reaction is preferred
Oxybenzoic acid；Epoxy reactive reaction temperature is preferably 20~25 DEG C；Weight proportion between reactant is preferred, the bis- dehydrogenations-of 1.6-
17a- hydroxyl-progesterone: peroxy acid=1g:0.45g；Proportion between reactant and solvent is preferred: the bis- dehydrogenation -17a- hydroxyls of 1,6-
Base-progesterone: organic solvent=1g:12ml；
The preferred glacial acetic acid of organic solvent described in above-mentioned chloride synthesis；Reaction temperature is preferably 30~35 DEG C；Reactant
Between weight proportion it is preferred: epoxy material: hydrogen chloride=1g:0.40g；Proportion between reactant and solvent is preferred: epoxy material: organic
Solvent=1g:15ml；
The preferred glacial acetic acid of organic solvent described in above-mentioned delmadinone acetate synthesis；Reaction temperature is preferably 40-45 DEG C；
The preferred p-methyl benzenesulfonic acid of acid catalyst, the weight proportion between reactant are preferred: chloride: acetic anhydride: acid catalyst=1g:
0.5g:0.02g；Proportion between reactant and solvent is preferred: chloride: organic solvent=1g:10ml.
The beneficial effects of the present invention are: first the bis- dehydrogenation -17a- hydroxyls Huangs of 1,6- are prepared by two steps with IDD in the present invention
Body ketone, then with the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- for raw material, it is anti-through three steps such as epoxidation, 6 chlorinations, 17 acetylations
Delmadinone acetate should be synthesized, relative to the prior synthesizing method of delmadinone acetate, has technological operation easy, produces
Economic and environment-friendly, the plurality of advantages such as synthesis total recovery is high, good product quality, and production cost is low avoid in conventional method using DDQ
Or environmental protection treatment is difficult and chlorination, etherificate, side reaction is more in dehydrogenation three-step reaction in tetrachloroquinone dehydrogenating technology, impurity is more, difficult pure
The shortcomings such as change；Delmadinone acetate is produced in the process of the present invention, and synthetic route is short, and technological operation is easy, synthesis yield
Height, good product quality, production cost reduce 40-45% than conventional production methods；Circulating sleeve can be recycled in solvent used in technique
With, it is not only economical, but also environmental protection, it is very beneficial to industrialized production.
Detailed description of the invention
Fig. 1 is traditional mode of production delmadinone acetate synthetic route chart.
Fig. 2 is the synthetic route chart that the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- are first prepared in the present invention with IDD.
Fig. 3 is that delmadinone acetate synthesis is prepared with the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6- again in the present invention
Route map.
Specific embodiment
In order to which main points and spirit of the invention are described in more detail, name several embodiments and be explained.
In the following example, the method may each comprise first using the deodorization distillate warp in soybean oil production process
The step of including Crystallization Separation, obtains phytosterol, specifically for example with prior art CN200680047150.1,
Method described in CN200710014171.X or CN101074258B is prepared from the deodorization distillate in soybean oil production process
Obtain phytosterol.Then using the method microbial fermentation in the prior art as described in CN1250709C phytosterol is turned
Turn to Isosorbide-5-Nitrae-androsadiendione i.e. IDD.It and then further include following steps.
Embodiment 1
A: the preparation of hydroxyl cyanogen object
In a 1000ml there-necked flask, starting material IDD100g, acetone cyanohydrin 250ml, temperature control to 40~45 is added
DEG C, stirring is completely dissolved IDD, and then 2% sodium carbonate aqueous alkali, about 2-2.5 is slowly added dropwise at 20~25 DEG C in temperature control
Hour drips off, then keeps the temperature and react 2~3 hours in 25~30 DEG C, and TLC confirms reaction end, and after having reacted, recycling is concentrated under reduced pressure
The solvent acetone cyanalcohol of 90-95% is applied, and residue is cooled to 20~25 DEG C, adds 500ml tap water elutriation, is filtered, filter
The processing of Ye Song waste water processing station, filter cake are crystallized with the alcohol water blend of 500ml 40%, obtain hydroxyl cyanogen object 98.6g, HPLC content
98.2%, weight yield 98.6%.
The preparation of the bis- dehydrogenation -17a- hydroxyl progesterones of B:1,6-
In a 1000ml there-necked flask, 35g magnesium powder, 800ml tetrahydrofuran, stirring is added, heat preservation is passed through in 30-35 DEG C
98g chloromethanes after having led to, continues to be stirred to react 4~6 hours, until magnesium powder disappears substantially, it is spare to obtain Grignard Reagent；
In another 1000ml there-necked flask, hydroxyl cyanogen object prepared by the above-mentioned A of 100g, 500mlTHF, stirring heating is added
To 50~55 DEG C, the above-mentioned about 800ml grignard reagent solution got ready is slowly added dropwise, drips off within about 1-1.5 hours, is further continued for heat preservation and stirs
Mix reaction 2~3 hours, TLC detects reaction end, and after having reacted, about 500ml 6N hydrochloric acid is slowly added dropwise to PH2-3, after dripping off
In 50~55 DEG C continuation hydrolysis 2-3 hours, TLC detection hydrolysis completely, after having reacted, about 90-95% is concentrated under reduced pressure out
The THF processing of THF, recycling are applied.600ml tap water is added in above-mentioned residual night again, and system is cooled to 5~10 DEG C, stirs
It mixes crystallization 2~3 hours, filters, filtrate send waste water processing station to handle, filter cake originally water washing to neutrality, 70 DEG C or less drying,
Obtain grignard object: 1,6- bis- dehydrogenation -17a- hydroxyl progesterone crude product 103.6g, HPLC contents 98.2%, weight yield 103.6%.
It takes the bis- dehydrogenation -17a- hydroxyl progesterone crude product 100g of above-mentioned 1,6- to be added into a 1000ml there-necked flask, adds 500ml wine
Essence is stirred at 30-35 DEG C and is made it completely dissolved, and 5g active carbon is then added, and is heated reflux 1.5-2 hours, is then dropped
Temperature filters, filter cake about 100ml alcohol foam washing, filter cake send producer to recycle, and filtrate is normal after merging with washing lotion while hot to 55-60 degree
Pressure is concentrated into recycling about 88-90% alcohol, then system is cooled to -5~0 DEG C, and stirring and crystallizing 3~4 hours, filtering, filtrate was returned
It receives solvent to apply with mother liquor material, filter cake is washed with a small amount of 50% ethanol water, and 70 DEG C or less drying obtain the bis- dehydrogenations-of 1,6-
17a- hydroxyl progesterone product 92.5g, 228.5~230.0 DEG C of fusing point, HPLC content 99.6%, weight yield 92.5%.
C, the preparation of 6 epoxy materials
In a 2000ml there-necked flask, the bis- dehydrogenation -17a- hydroxyl-progesterone 100g of 1,6-, ethyl acetate is added
700ml, stirring make it completely dissolved, and 20~25 DEG C of temperature control, benzoyl hydroperoxide is matched with 500ml ethyl acetate between 40g slowly is added dropwise
At solution, add within 0.5-1.0 hours, be further continued for after dripping off insulated and stirred react 12~16 hours, TLC detect reaction end,
After having reacted, 30g sodium hydrosulfite is first added, is stirred to react 0,5-1.0 hours, to destroy extra peroxy acid, then slowly filters, remove
Then 500ml tap water is added in the meta-toluic acid that dereaction generates, the ethyl acetate of filtrate decompression concentration and recovery 90-95%,
It stirring and crystallizing 2-3 hours, filters, washes, it is dry, obtain epoxy material crude product；The epoxy material crude product is added to 600ml alcohol again
In, heating makes it dissolve, and 5g active carbon is added, and reflux decoloration 1~1.5 hour is filtered while hot, and filter cake is steeped with about 80ml alcohol
It washes, merging filtrate and washing lotion, normal pressure is concentrated into about 85% alcohol of recycling, then system is cooled to 0~-5 DEG C, stirring and crystallizing 2~3
Hour, filtering, filter cake is washed with the ethanol solution of 50ml 50%, and 70 DEG C or less drying obtain epoxy material 93.8g, HPLC content
98.8%, weight yield 93.8%, filtrate and washing lotion merge, and recovered alcohol and epoxy material mother liquor material are covered respectively for lower batch of purification
In technique.
D, the preparation of chloride
In a 1000ml there-necked flask, the above-mentioned epoxy material of 100g, 1500ml glacial acetic acid is added, stirring is warming up to 40~45
DEG C, it makes it completely dissolved, then be slowly cooled to 20-25 DEG C, then starts slowly to be passed through dry hydrogen chloride gas, about logical 2-3
Hour, 30-35 DEG C of heat preservation confined reaction is continued at later 8-10 hours, led to 10 minutes hydrogen chloride gas every 4 hours therebetween, directly
Fully reacting is confirmed to TLC, and after having reacted, the soda bath 20g that 50% is slowly added dropwise in 1.0-1.5 hours is neutralized to system
PH5-6, then recycling about 90-95% glacial acetic acid is concentrated under reduced pressure, tap water is then added, stirring and crystallizing 2-3 hours, filters, washing,
Dry, obtain chloride: Delmadinone 103.9g, HPLC content 98.6%, this step react weight yield 103.9%；
E, the preparation of delmadinone acetate
In a 2000ml there-necked flask, the above-mentioned self-control chloride of 100g, 1000ml glacial acetic acid is added, is added with stirring
50g acetic anhydride, 2g p-methyl benzenesulfonic acid, then 40~45 DEG C are slowly ramped to, insulated and stirred is reacted 8~12 hours, TLC confirmation reaction
Terminal, after having reacted, be added 2ml 50% liquid alkaline in and strong acid, be then concentrated under reduced pressure, recycle the glacial acetic acid of 90-85%, most
600ml tap water is added afterwards, is cooled to 10~15 DEG C, stirring and crystallizing 2-3 hour, filters, is washed to neutrality, 70 DEG C of filter cake or less
Drying, obtains delmadinone acetate crude product 114.2g, HPLC content 97.8%；Filtrate and washing lotion merge, after recycling residual solvent
It is discharged into purification tank for liquid waste；Crude product is recrystallized by well-established law with alcohol and active carbon decoloring, obtains delmadinone acetate 95.8g, fusing point
228~232 DEG C, HPLC contains 99.5%, yield 95.8%.
Embodiment 2
A: the preparation of hydroxyl cyanogen object
In a 1000ml there-necked flask, starting material IDD100g, acetone cyanohydrin 50ml, methanol 500ml, temperature control is added
To 40~45 DEG C, stirring is completely dissolved IDD, and then temperature control is at 20~25 DEG C, and slowly the sodium hydroxide alkali of dropwise addition 2% is water-soluble
Liquid, about 2-2.5 hour drip off, then keep the temperature and react 2~3 hours in 25~30 DEG C, and TLC confirms reaction end, after having reacted, decompression
The methanol of concentration and recovery 90-95% and the mixing solvent of acetone cyanohydrin are applied, and residue is cooled to 20~25 DEG C, adds
500ml tap water elutriation, filtering, filtrate send waste water processing station to handle, and filter cake is crystallized with the alcohol water blend of 500ml 40%, obtain
Hydroxyl cyanogen object 97.8g, HPLC content 98.5%, weight yield 97.8%.
The preparation of the bis- dehydrogenation -17a- hydroxyl progesterones of B:1,6-
In a 1000ml there-necked flask, 35g magnesium powder, 800ml tetrahydrofuran, stirring is added, heat preservation is passed through in 30-35 DEG C
148g bromomethane after having led to, continues to be stirred to react 4~6 hours, until magnesium powder disappears substantially, it is spare to obtain Grignard Reagent；
In another 1000ml there-necked flask, hydroxyl cyanogen object prepared by the above-mentioned A of 100g, 500ml toluene, stirring heating is added
To 50~55 DEG C, the above-mentioned about 800ml grignard reagent solution got ready is slowly added dropwise, drips off within about 1-1.5 hours, is further continued for heat preservation and stirs
Mix reaction 2~3 hours, TLC detects reaction end, and after having reacted, about 500ml 6N sulfuric acid is slowly added dropwise to PH2-3, after dripping off
In 50~55 DEG C continuation hydrolysis 2-3 hours, TLC detection hydrolysis completely, after having reacted, about 90-95%THF is concentrated under reduced pressure out
With the mixing solvent of toluene (THF and toluene of recycling mix solvent and handle rear enclosure use).600ml is added in above-mentioned residual night again certainly
Water, and system is cooled to 5~10 DEG C, stirring and crystallizing 2~3 hours, filtering, filtrate sent waste water processing station to handle, and filter cake is used
Originally water washing to neutrality, 70 DEG C or less drying obtains grignard object: 1,6- bis- dehydrogenation -17a- hydroxyl progesterone crude product 102.4g,
HPLC content 97.8%, weight yield 102.4%.Take the bis- dehydrogenation -17a- hydroxyl progesterone crude product 100g of above-mentioned 1,6- by above-mentioned
The refining methd of the bis- dehydrogenation -17a- hydroxyl progesterone crude products of 1,6- described in one B of embodiment is recrystallized, and it is bis- de- to obtain 1,6-
Hydrogen -17a- hydroxyl progesterone product 91.2g, 229~231 DEG C of fusing point, HPLC content 99.5%, weight yield 91.2%.
C, the preparation of 6 epoxy materials
In a 2000ml there-necked flask, the bis- dehydrogenation -17a- hydroxyl-progesterone 100g of 1,6- are added, chloroform 700ml is stirred
It mixes and makes it completely dissolved, 20~25 DEG C of temperature control, slowly dropwise addition 40g neighbour's peroxide phthalic acid is made into molten with 500ml ethyl acetate
Liquid adds for 0.5-1.0 hours, and insulated and stirred is further continued for after dripping off and is reacted 12~16 hours, and TLC detects reaction end, has reacted
Afterwards, 30g sodium hydrosulfite is first added, is stirred to react 0,5-1.0 hours, to destroy extra peroxy acid, then slowly filters, removes dereaction
Then 500ml tap water, stirring analysis is added in the meta-toluic acid of generation, the ethyl acetate of filtrate decompression concentration and recovery 90-95%
It is 2-3 hours brilliant, it filters, washes, it is dry, obtain epoxy material crude product；The epoxy material crude product is added in 600ml alcohol again, is heated
It makes it dissolve, 5g active carbon is added, reflux decoloration 1~1.5 hour filters, filter cake about 80ml alcohol foam washing while hot, merges filter
Liquid and washing lotion, normal pressure is concentrated into about 85% alcohol of recycling, then system is cooled to 0~-5 DEG C, and stirring and crystallizing 2~3 hours, mistake
Filter, filter cake are washed with the ethanol solution of 50ml 50%, and 70 DEG C or less drying obtain epoxy material 91.6g, HPLC content 98.2%, weight
Yield 91.6% is measured, filtrate and washing lotion merge, and recovered alcohol and epoxy material mother liquor material are covered respectively in lower batch of process for refining.
D, the preparation of chloride
In a 1000ml there-necked flask, it being added the above-mentioned epoxy material of 100g, 1200ml dehydrated alcohol, stirring is warming up to 40~
It 45 DEG C, makes it completely dissolved, then is slowly cooled to 20-25 DEG C, then start slowly to be passed through dry hydrogen chloride gas, about logical 2-
3 hours, 30-35 DEG C of heat preservation confined reaction is continued at later 8-10 hours, led to 10 minutes hydrogen chloride gas every 4 hours therebetween,
Until TLC confirms fully reacting, after having reacted, the soda bath 20g that 50% is slowly added dropwise in 1.0-1.5 hours is neutralized to body
It is pH5-6, then recycling about 90-95% etoh solvent is concentrated under reduced pressure, tap water is then added, stirring and crystallizing 2-3 hours, filters,
Washing, dry, obtain chloride: Delmadinone 102.8g, HPLC content 98.2%, this step react weight yield 102.8%；
E, the preparation of delmadinone acetate
In a 2000ml there-necked flask, the above-mentioned self-control chloride of 100g, 1000ml toluene is added, is added with stirring 50g
Acetic anhydride, the 2g concentrated sulfuric acid, then 40~45 DEG C are slowly ramped to, insulated and stirred is reacted 8~12 hours, and TLC confirms reaction end, instead
After having answered, be added 2ml 50% liquid alkaline in and strong acid, be then concentrated under reduced pressure, recycle the solvent toluene of 90-85%, be eventually adding
600ml tap water is cooled to 10~15 DEG C, and stirring and crystallizing 2-3 hours, filtering was washed to neutrality, and 70 DEG C of filter cake or less dry,
Obtain delmadinone acetate crude product 110.6g, HPLC content 97.5%；Filtrate and washing lotion merge, and are discharged into after recycling residual solvent useless
Water treating pond；Crude product is recrystallized by well-established law with alcohol and active carbon decoloring, obtains serine progesterone acetate 92.6g, fusing point 228~232
DEG C, HPLC contains 99.7%, yield 92.6%.
Embodiment 3
A: the preparation of hydroxyl cyanogen object
In a 1000ml there-necked flask, starting material IDD100g is added, acetone cyanohydrin 50ml, DME500ml, temperature control is extremely
40~45 DEG C, stirring is completely dissolved IDD, and then 2% triethylamine aqueous alkali is slowly added dropwise at 20~25 DEG C in temperature control,
It drips off within about 2-2.5 hours, then keeps the temperature and reacted 2~3 hours in 25~30 DEG C, TLC confirms reaction end, after having reacted, depressurizes dense
The mixing solvent for retracting the DME and acetone cyanohydrin that receive 90-95% is applied, and residue is cooled to 20~25 DEG C, adds 500ml certainly
Water elutriation, filtering, filtrate send waste water processing station to handle, and filter cake is crystallized with the alcohol water blend of 500ml 40%, obtain hydroxyl cyanogen object
96.2g, HPLC content 98.2%, weight yield 96.2%.
The preparation of the bis- dehydrogenation -17a- hydroxyl progesterones of B:1,6-
In a 1000ml there-necked flask, 35g magnesium powder, 800ml ether is added, stirring is kept the temperature in 35-40 DEG C of dropwise addition 186g
Iodomethane after dripping off, continues to be stirred to react 4~6 hours, until magnesium powder disappears substantially, it is spare to obtain Grignard Reagent；
In another 1000ml there-necked flask, hydroxyl cyanogen object prepared by the above-mentioned A of 100g, 500mlTHF, stirring heating is added
To 50~55 DEG C, the above-mentioned about 800ml grignard reagent solution got ready is slowly added dropwise, drips off within about 1-1.5 hours, is further continued for heat preservation and stirs
Mix reaction 2~3 hours, TLC detects reaction end, and after having reacted, about 500ml 6N sulfuric acid is slowly added dropwise to PH2-3, after dripping off
In 50~55 DEG C continuation hydrolysis 2-3 hours, TLC detection hydrolysis completely, after having reacted, about 90-95%THF is concentrated under reduced pressure out
With the mixing solvent of ether (THF and ether of recycling mix solvent and handle rear enclosure use).600ml is added in above-mentioned residual night again certainly
Water, and system is cooled to 5~10 DEG C, stirring and crystallizing 2~3 hours, filtering, filtrate sent waste water processing station to handle, and filter cake is used
Originally water washing to neutrality, 70 DEG C or less drying obtains grignard object: 1,6- bis- dehydrogenation -17a- hydroxyl progesterone crude product 103.2g,
HPLC content 97.6%, weight yield 103.2%.Take the bis- dehydrogenation -17a- hydroxyl progesterone crude product 100g of above-mentioned 1,6- by above-mentioned
The refining methd of the bis- dehydrogenation -17a- hydroxyl progesterone crude products of 1,6- described in one B of embodiment is recrystallized, and it is bis- de- to obtain 1,6-
Hydrogen -17a- hydroxyl progesterone product 92.7g, 229~230 DEG C of fusing point, HPLC content 99.6%, weight yield 92.7%.
C, the preparation of 6 epoxy materials
In a 2000ml there-necked flask, the bis- dehydrogenation -17a- hydroxyl-progesterone 100g of 1,6-, tetrahydrofuran is added
700ml, stirring make it completely dissolved, and 20~25 DEG C of temperature control, are slowly added dropwise what 40g Peracetic acid was made into 500ml tetrahydrofuran
Solution adds for 0.5-1.0 hours, and insulated and stirred is further continued for after dripping off and is reacted 12~16 hours, and TLC detects reaction end, reaction
After complete, 30g sodium hydrosulfite is first added, is stirred to react 0,5-1.0 hours, to destroy extra peroxy acid, adds the burning of 50g50%
Then the ethyl acetate of recycling 90-95% is concentrated under reduced pressure except the acetic acid that dereaction generates in aqueous slkali, then system is down to room temperature,
500ml tap water is added, stirring and crystallizing 2-3 hours, filters, washes, it is dry, obtain epoxy material crude product；It is finally that the epoxy material is thick
Product are added in 600ml alcohol, and heating makes it dissolve, and 5g active carbon is added, and reflux decoloration 1~1.5 hour is filtered while hot, filtered
Cake about 80ml alcohol foam washing, merging filtrate and washing lotion, normal pressure are concentrated into about 85% alcohol of recycling, then system is cooled to 0~-
5 DEG C, stirring and crystallizing 2~3 hours, filtering, filter cake was washed with the ethanol solution of 50ml 50%, and 70 DEG C or less drying obtain epoxy material
90.4g, HPLC content 98.4%, weight yield 90.4%, filtrate and washing lotion merge, recovered alcohol and epoxy material mother liquor material difference
Set is in lower batch of process for refining.
D, the preparation of chloride
In a 1000ml there-necked flask, the above-mentioned epoxy material of 100g, 1500ml isopropanol is added, stirring is warming up to 40~45
DEG C, it makes it completely dissolved, then be slowly cooled to 20-25 DEG C, then starts slowly to be passed through dry hydrogen chloride gas, about logical 2-3
Hour, 30-35 DEG C of heat preservation confined reaction is continued at later 8-10 hours, led to 10 minutes hydrogen chloride gas every 4 hours therebetween, directly
Fully reacting is confirmed to TLC, and after having reacted, the soda bath 20g that 50% is slowly added dropwise in 1.0-1.5 hours is neutralized to system
PH5-6, then recycling about 90-95% isopropanol is concentrated under reduced pressure, tap water is then added, stirring and crystallizing 2-3 hours, filters, washing,
Dry, obtain chloride: Delmadinone 102.6g, HPLC content 98.0%, this step react weight yield 102.6%；
E, the preparation of delmadinone acetate
In a 2000ml there-necked flask, the above-mentioned self-control chloride of 100g, 1000ml chloroform is added, is added with stirring 50g
Acetic anhydride, 2g p-methyl benzenesulfonic acid, then 40~45 DEG C are slowly ramped to, insulated and stirred is reacted 8~12 hours, and TLC confirmation reaction is eventually
Point, after having reacted, be added 2ml 50% liquid alkaline in and strong acid, be then concentrated under reduced pressure, recycle the chloroform of 90-85%, finally plus
Enter 600ml tap water, is cooled to 10~15 DEG C, stirring and crystallizing 2-3 hours, filtering was washed to neutrality, 70 DEG C of filter cake or less bakings
It is dry, obtain delmadinone acetate crude product 113.5g, HPLC content 97.2%；Filtrate and washing lotion merge, and recycle residual solvent heel row
Enter purification tank for liquid waste；Crude product is recrystallized by well-established law with alcohol and active carbon decoloring, obtains delmadinone acetate 92.7g, fusing point 228
~232 DEG C, HPLC contains 99.3%, yield 92.7%.
The above content is combine specific preferred embodiment to the further description of the invention made, and it cannot be said that originally
The specific implementation of invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, not
Under the premise of being detached from present inventive concept, several simple deductions and replacement can also be made, all shall be regarded as belonging to guarantor of the invention
Protect range.
Claims (10)
1. a kind of preparation method of Delmadinone makes first the method includes using Isosorbide-5-Nitrae-androsadiendione i.e. IDD for raw material
17 ketone in IDD molecule react under base catalysis in the first organic solvent with acetone cyanohydrin, in 17 introducing β-hydroxyls
Base and alpha-cyano obtain hydroxyl cyanogen object；Then hydroxyl cyanogen object is prepared into the presence of methyl-magnesium-halide, the second organic solvent and acid
To the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6-；6 epoxy materials are synthesized again, and it is pregnant to obtain described ground horse for 6 chlorides of synthesis thereafter
Ketone.
2. the method according to claim 1, wherein first organic solvent be acetone cyanohydrin, methylene chloride,
One or more of DME, ethyl acetate, THF and C4 or less low-carbon alcohols, preferably described first organic solvent are methanol.
3. the method according to claim 1, wherein the alkali is organic base or inorganic base, preferably pyridine, three
One of ethamine, sodium carbonate and sodium hydroxide are a variety of, more preferable sodium carbonate.
4. the method according to claim 1, wherein second organic solvent is methylene chloride, toluene, ether
One or more of with THF, preferably described second organic solvent is THF.
5. the method according to claim 1, wherein the acid is organic acid or inorganic acid, preferably acetic acid, right
One of toluenesulfonic acid, hydrochloric acid and sulfuric acid are a variety of, more preferable hydrochloric acid.
6. the method according to claim 1, wherein reaction temperature is in the step of IDD reaction generates hydroxyl cyanogen object
10~100 DEG C, reaction temperature is 30~100 DEG C in the step of reaction of hydroxyl cyanogen object generates 1,6- bis- dehydrogenation -17a- hydroxyl progesterones,
It and include first adding methyl-magnesium-halide into the second organic solvent and hydroxyl cyanogen object grignard addition reaction occurs, then add in reaction process
The grignard object that acid adding obtains grignard addition reaction hydrolyzes, and organic solvent is then recovered under reduced pressure and obtains institute after adding water to carry out elutriation
State the bis- dehydrogenation -17a- hydroxyl progesterones of 1,6-.
7. the method according to claim 1, wherein in the step of synthesizing 6 epoxy materials, including 1,6- is bis-
Dehydrogenation -17a- hydroxyl progesterone dissolves in third organic solvent, adds peroxy acid reaction that the epoxy material is prepared；By epoxy
In the step of object synthesizing chlorinated object, that is, Delmadinone, including epoxy material dissolved in the 4th organic solvent, adds hydrogen chloride gas anti-
The Delmadinone should be prepared.
8. the method according to the description of claim 7 is characterized in that the third organic solvent is selected from methanol, ethyl alcohol, DME, four
One or both of hydrogen furans, chloroform, ethyl acetate, the peroxy acid are Peracetic acid, benzoyl hydroperoxide, adjacent peroxide benzene first
One of acid anhydrides；4th organic solvent is selected from glacial acetic acid, C4 or less low-carbon alcohols, ether, DMF, DME, ethyl acetate, four
One of hydrogen furans, dioxane.
9. the method according to claim 1, wherein the method also includes first using nutrient medium and one kind
Or multiple-microorganism strain makes phytosterol that Isosorbide-5-Nitrae-androsadiendione i.e. IDD be prepared after microbial fermentation.
10. according to the method described in claim 9, it is characterized in that, in the nutrient medium comprising glucose, corn pulp,
One of inorganic salts, yeast extract, beef extract and peptone are a variety of, the microorganism fungus kind be include Mycobacterium, sickle
One of spore category and bacillus amyloliquefaciens are a variety of.
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