CN109453545A - The liquid dispensing device of Column eluate - Google Patents
The liquid dispensing device of Column eluate Download PDFInfo
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- CN109453545A CN109453545A CN201811561735.6A CN201811561735A CN109453545A CN 109453545 A CN109453545 A CN 109453545A CN 201811561735 A CN201811561735 A CN 201811561735A CN 109453545 A CN109453545 A CN 109453545A
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Abstract
The invention belongs to chemical fields, specifically disclose a kind of liquid dispensing device of Column eluate.The liquid dispensing device of above-mentioned Column eluate include: main line, rear end access main line bye-pass, be set on main line static mixer, be set to static mixer downstream eluent detector, and respectively with bye-pass, eluent detector communicate to connect electric control module.Electric control module is configured to the supply that the target component received from eluent detector adjusts solution.Eluent is flow in chromatographic column by the rear end of main line.The present invention, which can be realized, to be reduced occupied area, improves elution efficiency, replacement concentration time resource-saving, and reduces the purpose of cleaning difficulty.
Description
Technical field
The present invention relates to chemical fields, and in particular to a kind of liquid dispensing device of Column eluate.
Background technique
Ion exchange column is widely used in chemical industry, biology, pharmaceutical field, the purifying for target compound.It is existing
Some Column eluate liquid dispensing devices are stirred by pouring into a certain amount of hydrochloric acid and sodium chloride solution in dissolving tank,
And after mixing evenly, the mode that mixed solution is passed through chromatographic column (into column step) is eluted.
Since existing Column eluate liquid dispensing device is mixed by mechanical stirring, incorporation time is longer, blending tank
It is bulky, a large amount of construction areas can be not only occupied, also will affect the accuracy of eluate concentration；And it can be dense in replacement eluent
When spending, a large amount of eluents of waste are led to the problem of；When cleaning dissolving tank, a large amount of water of consumption are led to the problem of, and clean hardly possible
It spends bigger.
Further, since existing Column eluate liquid dispensing device cannot change eluate concentration in time, washed in daily
During de-, often to stop causing existing Column eluate to be matched into column step because preparing the eluent of various concentration
The elution efficiency of liquid device is very low, is not suitable for automatic continuous production.
Therefore, this field needs that a kind of occupied area is small, elution efficiency is high, replacement concentration time resource-saving, and clean it is difficult
Lesser Column eluate liquid dispensing device is spent, to overcome above-mentioned technical problem of the existing technology.
Summary of the invention
A brief summary of one or more aspects is given below to provide to the basic comprehension in terms of these.This general introduction is not
The extensive overview of all aspects contemplated, and be both not intended to identify critical or decisive element in all aspects also non-
Attempt to define the range in terms of any or all.Its unique purpose is to provide the one of one or more aspects in simplified form
A little concepts are with the sequence for more detailed description given later.
In order to solve the above problem of the prior art, the present invention provides a kind of liquid dispensing device of Column eluate, with
It realizes and reduces occupied area, improves elution efficiency, replacement concentration time resource-saving, and reduce the purpose of cleaning difficulty.
The liquid dispensing device of above-mentioned Column eluate provided by the invention, comprising:
Main line, water flow to rear end from the front end of above-mentioned main line；
Bye-pass, solution flow to rear end from the front end of above-mentioned bye-pass, and above-mentioned main line is accessed in the rear end of above-mentioned bye-pass
Above-mentioned solution to be delivered in above-mentioned main line；
Static mixer, above-mentioned static mixer are set on above-mentioned main line, the water in above-mentioned main line with it is above-mentioned molten
After liquid converges, it flow to above-mentioned static mixer and is mixed to form eluent, above-mentioned eluent is flowed by the rear end of above-mentioned main line
To chromatographic column；
Eluent detector, above-mentioned eluent detector are set to the downstream of above-mentioned static mixer on above-mentioned main line,
With the target component for monitoring above-mentioned eluent；And
Electric control module, above-mentioned electric control module respectively with above-mentioned bye-pass and above-mentioned eluent detector communication link
It connects, above-mentioned electric control module is configured to adjust above-mentioned solution from the target component that above-mentioned eluent detector receives
Supply.
Preferably, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned bye-pass may include:
First bye-pass and the second bye-pass, above-mentioned solution include that conductivity adjusts solution and ph adjusting solution；
Above-mentioned conductivity adjusts solution and flows to rear end, the rear end of above-mentioned first bye-pass from the front end of above-mentioned first bye-pass
Above-mentioned main line is accessed so that above-mentioned conductivity adjusting solution to be delivered in above-mentioned main line；
Above-mentioned ph adjusts solution and flows to rear end from the front end of above-mentioned second bye-pass；The rear end of above-mentioned second bye-pass is accessed
Above-mentioned main line is above-mentioned ph adjusting solution to be delivered in above-mentioned main line；
On above-mentioned main line, the rear end on-position of above-mentioned second bye-pass is accessed in the rear end of above-mentioned first bye-pass
The downstream of position；
Above-mentioned static mixer may include: the first static mixer and the second static mixer, and above-mentioned second is static mixed
Clutch is located at the downstream of above-mentioned first static mixer, and above-mentioned eluent includes the first eluent and the second eluent；
After water and above-mentioned conductivity adjusting solution in above-mentioned main line converge, it flow to above-mentioned first static mixer mixing
Above-mentioned second static mixer is flow to form the first eluent after above-mentioned first eluent and above-mentioned ph adjusting solution converge
It is mixed to form the second eluent, above-mentioned second eluent is flow in chromatographic column by the rear end of above-mentioned main line；
Above-mentioned eluent detector may include: electric conductivity detector and ph detector；
Above-mentioned electric conductivity detector is set to the downstream of above-mentioned first static mixer on above-mentioned main line, for monitoring
The conductivity of above-mentioned eluent, above-mentioned ph detector are set to the downstream of above-mentioned second static mixer on above-mentioned main line, with
For monitoring the ph value of above-mentioned eluent；
Above-mentioned electric control module is configured to the conductivity received from above-mentioned electric conductivity detector and adjusts above-mentioned electricity
Conductance adjusts the supply of solution, and above-mentioned electric control module is configured to the ph value received from above-mentioned ph detector adjusting
Above-mentioned ph adjusts the supply of solution.
Preferably, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
It include: water supply module；
Above-mentioned water supply module may include: water pump, inlet valve and flowing water Valve；
The water inlet of above-mentioned water pump accesses water source of supply by above-mentioned inlet valve, and the water outlet of above-mentioned water pump passes through above-mentioned
Flowing water Valve accesses to the front end of above-mentioned main line；
Above-mentioned water pump is used to the water in above-mentioned water source of supply being supplied to above-mentioned main line, and above-mentioned inlet valve is for controlling
The opening and closing of the inlet pipeline formed between above-mentioned water source of supply and the water inlet of above-mentioned water pump, above-mentioned flowing water Valve is for controlling
State the opening and closing of the outlet pipeline formed between the water outlet of water pump and the front end of above-mentioned main line；
Above-mentioned electric control module is also communicated to connect with above-mentioned water supply module, and above-mentioned electric control module is additionally configured to lead to
Cross the supply that above-mentioned water supply module adjusts above-mentioned water.
Preferably, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned water supply module may be used also
To include: return line and water pump return valve；
The both ends of above-mentioned return line are respectively connected on above-mentioned inlet pipeline and above-mentioned outlet pipeline, above-mentioned water pump reflux
Valve is set on above-mentioned return line, and the supply for adjusting above-mentioned water.
Optionally, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
It include: that conductivity adjusts solution supply module；
It may include: the first storage tank, the first metering pump, first outlet pulse that above-mentioned conductivity, which adjusts solution supply module,
Damper, first outlet pressure gauge and first outlet back pressure valve；
The entrance of above-mentioned first metering pump accesses to above-mentioned first storage tank, and the outlet of above-mentioned first metering pump passes sequentially through
Above-mentioned first outlet pulse damper, above-mentioned first outlet pressure gauge and above-mentioned first outlet back pressure valve access to above-mentioned first
The front end of bye-pass；
Above-mentioned first metering pump, which is used to the conductivity in above-mentioned first storage tank adjusting solution, passes through above-mentioned first outlet
Pulse damper and above-mentioned first outlet back pressure valve are supplied in above-mentioned first bye-pass；
It further includes the first safety line and the first safety-valve that above-mentioned conductivity, which adjusts solution supply module,；
The both ends of above-mentioned first safety line are respectively connected to the outlet of above-mentioned first storage tank and above-mentioned first metering pump,
Above-mentioned first safety-valve is set in above-mentioned first safety line.
Preferably, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
It include: third static mixer and the first surge tank；
Above-mentioned third static mixer and above-mentioned first surge tank are respectively arranged on above-mentioned main line, quiet from above-mentioned first
Above-mentioned first eluent of state mixer outflow flow to above-mentioned third static mixer, flows out from above-mentioned third static mixer
Above-mentioned first eluent flow to above-mentioned first surge tank；
Above-mentioned liquid dispensing device can also include the first sample cock；
Above-mentioned first sample cock is set on above-mentioned main line, and is flowed out from above-mentioned first surge tank for sampling
Above-mentioned first eluent.
Optionally, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
It include: that ph adjusts solution supply module；
It may include: that the second storage tank, the second metering pump, second outlet are pulse damped that above-mentioned ph, which adjusts solution supply module,
Device, second outlet pressure gauge and second outlet back pressure valve；
The entrance of above-mentioned second metering pump accesses to above-mentioned second storage tank, and the outlet of above-mentioned second metering pump passes sequentially through
Above-mentioned second outlet pulse damper, above-mentioned second outlet pressure gauge and above-mentioned second outlet back pressure valve access to above-mentioned second
The front end of bye-pass；
Above-mentioned second metering pump, which is used to the ph in above-mentioned second storage tank adjusting solution, passes through above-mentioned second outlet pulse
Damper and above-mentioned second outlet back pressure valve are supplied in above-mentioned second bye-pass；
It further includes the second safety line and the second safety-valve that above-mentioned ph, which adjusts solution supply module,；
The both ends of above-mentioned second safety line are respectively connected to the outlet of above-mentioned second storage tank and above-mentioned second metering pump,
Above-mentioned second safety-valve is set in above-mentioned second safety line.
Preferably, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
Including the 4th static mixer and the second surge tank；
Above-mentioned 4th static mixer and above-mentioned second surge tank are respectively arranged on above-mentioned main line, quiet from above-mentioned second
Above-mentioned second eluent of state mixer outflow flow to above-mentioned 4th static mixer, flows out from above-mentioned 4th static mixer
Above-mentioned second eluent flow to above-mentioned second surge tank；
Above-mentioned liquid dispensing device can also include: the second sample cock；
Above-mentioned second sample cock is set on above-mentioned main line, and is flowed out from above-mentioned second surge tank for sampling
Above-mentioned second eluent.
Optionally, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned liquid dispensing device can be with
It include: outlet electromagnetic flowmeter and outlet pressure transmitter；
Above-mentioned outlet electromagnetic flowmeter and above-mentioned outlet pressure transmitter are respectively arranged on the rear end of above-mentioned main line, and
And it is communicated to connect respectively with above-mentioned electric control module；
Above-mentioned outlet electromagnetic flowmeter is used to monitor the flow value of the rear end of above-mentioned main line；
Above-mentioned outlet pressure transmitter is used to monitor the pressure value of the rear end of above-mentioned main line；
Above-mentioned liquid dispensing device further includes into column tube road, into column valve door, discharging of waste liquid pipeline and discharging of waste liquid valve；
It is above-mentioned into column valve door include into column manually-operated gate and into column electromagnetic valve；
Above-mentioned discharging of waste liquid valve includes discharging of waste liquid manually-operated gate and discharging of waste liquid electromagnetic valve；
When open it is above-mentioned into column valve door and close above-mentioned discharging of waste liquid valve when, the rear end of above-mentioned main line accesses to above-mentioned
Into the front end on column tube road, the above-mentioned rear end into column tube road is accessed in above-mentioned chromatographic column, and above-mentioned second eluent is conveyed
In to above-mentioned chromatographic column；
When close it is above-mentioned into column valve door and open above-mentioned discharging of waste liquid valve when, the rear end of above-mentioned main line accesses to above-mentioned
Discharging of waste liquid piping connection, above-mentioned discharging of waste liquid pipeline are used to discharge above-mentioned second eluent of above-mentioned main line conveying.
Optionally, in the liquid dispensing device of above-mentioned Column eluate provided by the invention, above-mentioned water may include: from
Sub- water；And/or
It may include: sodium chloride solution that above-mentioned conductivity, which adjusts solution,；And/or
It may include: hydrochloric acid solution that above-mentioned ph, which adjusts solution,；And/or
Above-mentioned electric control module may include: PLC.
Detailed description of the invention
After the detailed description for reading embodiment of the disclosure in conjunction with the following drawings, it better understood when of the invention
The feature and advantage.In the accompanying drawings, each component is not necessarily drawn to scale, and has similar correlation properties or feature
Component may have same or similar appended drawing reference.
Fig. 1 is the structural schematic diagram of the liquid dispensing device for the Column eluate that one embodiment of the present of invention provides.
Fig. 2 be another embodiment of the present invention provides Column eluate liquid dispensing device structural schematic diagram.
Fig. 3 be another embodiment of the present invention provides Column eluate liquid dispensing device structural schematic diagram.
Description of symbols:
1 water pump return valve；
2 water pumps；
3 first metering pumps；
4 first safety-valves；
5 first outlet pulse dampers；
6 first outlet pressure gauges；
7 first outlet back pressure valves；
8 second metering pumps；
9 second safety-valves
10 second outlet pulse dampers；
11 second outlet pressure gauges；
12 second outlet back pressure valves；
13 first static mixers；
14 second static mixers；
15 first surge tanks；
16 electric conductivity detectors；
17 first sample cocks；
18 third static mixers；
19 the 4th static mixers；
20 second surge tanks；
21 ph detectors；
22 outlet electromagnetic flowmeters；
23 outlet pressure transmitters；
24 into column manually-operated gate；
25 into column electromagnetic valve；
26 discharging of waste liquid manually-operated gates；
27 discharging of waste liquid electromagnetic valves；
28 second sample cocks；
29 first storage tanks；
30 second storage tanks.
Specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in detail.Note that below in conjunction with attached drawing and specifically real
The aspects for applying example description is merely exemplary, and is understood not to carry out any restrictions to protection scope of the present invention.
It provides and is described below so that those skilled in the art can implement and using the present invention and be incorporated into specific
In application background.Various modifications and various uses in different application will be readily apparent for those skilled in the art
, and general principle defined herein is applicable to the embodiment of wider range.The present invention is not limited to herein as a result,
The embodiment provided, but the broadest range consistent with principle disclosed herein and novel features should be awarded.
In the following detailed description, many specific details are elaborated to provide to more thorough understanding of the invention.However, right
In it should be apparent to those skilled in the art that practice of the invention can need not be confined to these details.In other words, known
Structure and device be shown in block diagram form without display the details of, to avoid the fuzzy present invention.
Note that use in the case where, it is mark left, right, front and rear, top, bottom, positive and negative, clockwise and anticlockwise only
It is used for convenience, and does not imply that any specific fixed-direction.In fact, they are used for reflection pair
Relative position and/or direction between the various pieces of elephant.
In order to solve the above problem of the prior art, the present invention provides a kind of realities of the liquid dispensing device of Column eluate
Example is applied, reduces occupied area, raising elution efficiency, replacement concentration time resource-saving to realize, and reduce the purpose of cleaning difficulty.
As shown in Figure 1, may include: front end in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment
The main line of water supply module is connected, water flows to rear end from the front end of above-mentioned main line.
Above-mentioned water supply module may include: water pump 2, inlet valve, flowing water Valve, return line and water pump reflux
Valve 1.
The water inlet of above-mentioned water pump 2 passes through above-mentioned inlet valve access water source of supply (not being painted), the water outlet of above-mentioned water pump 2
Mouth accesses to the front end of above-mentioned main line by above-mentioned flowing water Valve.Above-mentioned water pump 2 is used to supply in the water in above-mentioned water source of supply
It should be to above-mentioned main line.
Above-mentioned inlet valve, for controlling the water inlet pipe formed between above-mentioned water source of supply and the water inlet of above-mentioned water pump 2
The opening and closing on road.
Above-mentioned flowing water Valve, for control formed between the water outlet of above-mentioned water pump 2 and the front end of above-mentioned main line go out
The opening and closing of water lines.
The both ends of above-mentioned return line are separately connected above-mentioned inlet pipeline and above-mentioned outlet pipeline.
Above-mentioned water pump return valve 1 is set to above-mentioned return line, for adjusting the supply of above-mentioned water.
The PLC electric control module (not being painted) of Column eluate liquid dispensing device, can be logical with above-mentioned water supply module
Letter connection.Above-mentioned PLC electric control module is configurable to according to the flow and pressure monitored in real time, the above-mentioned water of frequency control
The water pump 2 of supply module, with the supply of the above-mentioned water of on-line control.
When increasing due to the flow of above-mentioned water pump 2, the pressure in above-mentioned main line also be will increase, when above-mentioned pressure reaches
When stating maximum pressure (the limiting pressure value) that chromatographic column can bear, above-mentioned PLC electric control module can be above-mentioned by reducing
The mode of the flow of water pump 2 reduces pressure.
It will be understood to those skilled in the art that the specific structure of above-mentioned water supply module, only provided in this embodiment
A kind of preferred embodiment is mainly used for the water in above-mentioned water source of supply supplied to above-mentioned main line, and passes through above-mentioned PLC electric-controlled
Molding block adjusts the supply of above-mentioned water.In other embodiments, those skilled in the art can also be using other structures
Water supply module, to realize the purpose that the water in above-mentioned water source of supply is supplied to above-mentioned main line；Or using other electrical
Control module, to obtain the effect for the supply for adjusting above-mentioned water.
It will also be understood by those skilled in the art that the water used in the present embodiment can be deionized water, thus more preferably
Ground controls the conductivity of the first eluent.In other embodiments, those skilled in the art can also using tap water or its
He has the water of a small amount of ion, to prepare relatively low first eluent of conductivity precision.
As shown in Figure 1, in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment, before can also including:
End connection conductivity adjusts the first bye-pass of solution supply module, the first static mixer 13, third static mixer 14, the
One surge tank 15, electric conductivity detector 16 and the first sample cock 17.
Above-mentioned main line is accessed in the rear end of above-mentioned first bye-pass, will be used to adjust the sodium chloride solution conveying of conductivity
In to above-mentioned main line, above-mentioned sodium chloride solution flows to rear end from the front end of above-mentioned first bye-pass.
It may include: the first storage tank 29, the first metering pump 3, first outlet that above-mentioned conductivity, which adjusts solution supply module,
Pulse damper 5, first outlet pressure gauge 6 and first outlet back pressure valve 7.
The entrance of above-mentioned first metering pump 3 accesses to above-mentioned first storage tank 29, and the outlet of above-mentioned first metering pump 3 is successively
By above-mentioned first outlet pulse damper 5, above-mentioned first outlet pressure gauge 6 and above-mentioned first outlet back pressure valve 7, with
Access to the front end of above-mentioned first bye-pass.
Above-mentioned first metering pump 3 is used for the high concentration sodium chloride solution in above-mentioned first storage tank 29, passes through above-mentioned the
One outlet pulses damper 5 and above-mentioned first outlet back pressure valve 7 are supplied in above-mentioned first bye-pass.
Above-mentioned first outlet pulse damper 5 is used to provide above-mentioned high concentration sodium chloride solution in the form of a pulse, thus
Adjust the concentration of sodium chloride in above-mentioned first eluent.
Above-mentioned first outlet back pressure valve 7, for adjusting the above-mentioned chlorination in above-mentioned conductivity adjusting solution supply module
The pressure of sodium solution.
It can also include: the first safety line and the first safety-valve 4 that above-mentioned conductivity, which adjusts solution supply module,.
The both ends of above-mentioned first safety line are respectively connected to the outlet of above-mentioned first storage tank 29 and above-mentioned first metering pump 3.On
The first safety-valve 4 is stated to be set in above-mentioned first safety line.
Above-mentioned first static mixer 13 is set on above-mentioned main line, and the water in above-mentioned main line and above-mentioned sodium chloride are molten
After liquid converges, it flow to above-mentioned first static mixer 13 and is mixed to form the first eluent.
Above-mentioned third static mixer 14 and above-mentioned first surge tank 15, above-mentioned be respectively arranged on above-mentioned main line
The downstream of one static mixer 13.It is quiet that above-mentioned first eluent flowed out from above-mentioned first static mixer 13 flow to above-mentioned third
State mixer 14, above-mentioned first eluent flowed out from above-mentioned third static mixer 14 flow to above-mentioned first surge tank 15, from
And the pulsed sodium chloride solution that the above-mentioned first outlet pulse damper 5 of homogeneous is supplied.Above-mentioned first eluent passes through above-mentioned master
The rear end of pipeline is flow in chromatographic column.
Above-mentioned electric conductivity detector 16 can be set in the downstream of above-mentioned first surge tank 15 on above-mentioned main line, with
In the conductivity for monitoring above-mentioned first eluent, to obtain the conductivity of accurate first eluent.
Above-mentioned first sample cock 17 can be set in the downstream of above-mentioned first surge tank 15 on above-mentioned main line, be used for
Sample above-mentioned first eluent flowed out from above-mentioned first surge tank 15.
Above-mentioned PLC electric control module (not being painted) can be examined with above-mentioned first bye-pass and above-mentioned conductivity respectively
Instrument 16 is surveyed to communicate to connect.Above-mentioned PLC electric control module is configurable to what basis was received from above-mentioned electric conductivity detector 16
The real-time conductivity of first eluent, the supply of the above-mentioned sodium chloride solution of on-line control, to introduce closed-loop control.
It will be understood to those skilled in the art that above-mentioned conductivity adjusts the specific structure of solution supply module, only originally
A kind of preferred embodiment that embodiment provides is mainly used for the sodium chloride solution in above-mentioned first storage tank 29 being supplied to above-mentioned master
Pipeline, and the supply of above-mentioned sodium chloride solution is adjusted by above-mentioned PLC electric control module, to adjust above-mentioned first eluent
Conductivity.In other embodiments, those skilled in the art can also adjust solution using the conductivity of other structures and supply
Module is answered, to realize the purpose that the sodium chloride solution in above-mentioned first storage tank 29 is supplied to above-mentioned main line；Or use it
His electric control module, to obtain the effect for the supply for adjusting above-mentioned sodium chloride solution.
It will also be understood by those skilled in the art that adjusting solution, only this reality as conductivity using sodium chloride solution
A kind of concrete scheme of example offer is provided.In other embodiments, those skilled in the art can also use other ph values close to 7
Solution, to realize the purpose for the conductivity for adjusting above-mentioned first eluent.
As shown in Figure 1, can also include: out in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment
Mouthful electromagnetic flowmeter 22, outlet pressure transmitter 23, into column tube road, into column valve door, discharging of waste liquid pipeline and discharging of waste liquid valve
Door.
After above-mentioned outlet electromagnetic flowmeter 22 and above-mentioned outlet pressure transmitter 23 are respectively arranged at above-mentioned main line
On end, and communicated to connect respectively with above-mentioned PLC electric control module.Above-mentioned outlet electromagnetic flowmeter 22 is for monitoring above-mentioned master
The flow value of the rear end of pipeline.Above-mentioned outlet pressure transmitter 23 is used to monitor the pressure value of the rear end of above-mentioned main line.
It is above-mentioned into column valve door may include: into column manually-operated gate 23, and into column electromagnetic valve 25.
Above-mentioned discharging of waste liquid valve may include: discharging of waste liquid manually-operated gate 26 and discharging of waste liquid electromagnetic valve 27.
When open it is above-mentioned into column valve door and close above-mentioned discharging of waste liquid valve when, the rear end of above-mentioned main line accesses to above-mentioned
Into the front end on column tube road, the above-mentioned rear end into column tube road is accessed in above-mentioned chromatographic column, and above-mentioned first eluent is conveyed
In to above-mentioned chromatographic column.
When close it is above-mentioned into column valve door and open above-mentioned discharging of waste liquid valve when, the rear end of above-mentioned main line accesses to above-mentioned
Discharging of waste liquid piping connection, above-mentioned discharging of waste liquid pipeline are used to discharge above-mentioned first eluent of above-mentioned main line conveying.
It will be understood to those skilled in the art that using above-mentioned outlet electromagnetic flowmeter 22 and above-mentioned outlet pressure transmitter
23 scheme, only a kind of preferred embodiment provided in this embodiment, is mainly used for monitoring the flow value of the rear end of above-mentioned main line
And pressure value.In other embodiments, even if those skilled in the art does not use above-mentioned outlet electromagnetic flowmeter 22 and above-mentioned
Outlet pressure transmitter 23 also may be implemented to flow to above-mentioned first eluent in chromatographic column by the rear end of above-mentioned main line
Purpose.
It will also be understood by those skilled in the art that using it is above-mentioned into column tube road, it is above-mentioned into column valve door, above-mentioned discharging of waste liquid
The scheme of pipeline and above-mentioned discharging of waste liquid valve, only a kind of preferred embodiment provided in this embodiment, is mainly used for according to upper
The conductivity for above-mentioned first eluent that electric conductivity detector 16 monitors is stated, is selected the first eluent of conductivity qualification is defeated
It send to above-mentioned chromatographic column；Or underproof first eluent of conductivity is discharged.In other embodiments, the skill of this field
Even if art personnel do not use it is above-mentioned into column tube road, it is above-mentioned into column valve door, above-mentioned discharging of waste liquid pipeline and above-mentioned discharging of waste liquid valve
Door, also may be implemented that above-mentioned first eluent is made to flow to the purpose in chromatographic column by the rear end of above-mentioned main line.
Due in the practical application of the liquid dispensing device of Column eluate, it is not necessary to adjust the conductance of eluent
Rate, there may also be the demands for the ph value for adjusting eluent.The liquid dispensing device of another Column eluate is also provided herein
Embodiment.
In the liquid dispensing device of above-mentioned Column eluate provided in this embodiment, the conductivity that is provided in previous embodiment
Solution supply module is adjusted, ph is could alternatively be and adjusts solution supply module.
As shown in Fig. 2, may include: front end in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment
Connect the second bye-pass, the second static mixer 18, the 4th static mixer 19, second buffering that ph adjusts solution supply module
Tank 20, ph detector 21 and the second sample cock 28.Above-mentioned main line is accessed in the rear end of above-mentioned second bye-pass, will use
It is delivered in above-mentioned main line in the hydrochloric acid solution for adjusting ph value, above-mentioned hydrochloric acid solution is flowed to from the front end of above-mentioned second bye-pass
Rear end.
It may include: the second storage tank 30, the second metering pump 8, second outlet pulse that above-mentioned ph, which adjusts solution supply module,
Damper 10, second outlet pressure gauge 11 and second outlet back pressure valve 12.
The entrance of above-mentioned second metering pump 8 accesses to above-mentioned second storage tank 20, and the outlet of above-mentioned second metering pump 8 is successively
By above-mentioned second outlet pulse damper 10, above-mentioned second outlet pressure gauge 11 and above-mentioned second outlet back pressure valve 12,
To access to the front end of above-mentioned second bye-pass.
Above-mentioned second metering pump 8 is used to the high salt concentration acid solution in above-mentioned second storage tank 30 passing through above-mentioned second
Outlet pulses damper 10 and above-mentioned second outlet back pressure valve 12 are supplied in above-mentioned second bye-pass.
Above-mentioned second outlet pulse damper 10 for providing above-mentioned high salt concentration acid solution in the form of a pulse, to adjust
Save the concentration of hydrochloric acid in the second eluent.
Above-mentioned second outlet back pressure valve 12, for adjusting the above-mentioned hydrochloric acid solution in above-mentioned ph adjusting solution supply module
Pressure.
It can also include: the second safety line and the second safety-valve 9 that above-mentioned ph, which adjusts solution supply module,.It is above-mentioned
The both ends of second safety line are respectively connected to the outlet of above-mentioned second storage tank 30 and above-mentioned second metering pump 8.Above-mentioned
Two safety-valves 9 are set in above-mentioned second safety line.
Above-mentioned second static mixer 18 is set on above-mentioned main line, the water in above-mentioned main line and above-mentioned hydrochloric acid solution
After converging, it flow to above-mentioned second static mixer 18 and is mixed to form the second eluent.
Above-mentioned 4th static mixer 19 and above-mentioned second surge tank 20, above-mentioned be respectively arranged on above-mentioned main line
The downstream of two static mixers 18.It is quiet that above-mentioned second eluent flowed out from above-mentioned second static mixer 18 flow to the above-mentioned 4th
State mixer 19, above-mentioned second eluent flowed out from above-mentioned 4th static mixer 19 flow to above-mentioned second surge tank 20, from
And the pulsed hydrochloric acid solution that the above-mentioned second outlet pulse damper 10 of homogeneous is supplied.Above-mentioned second eluent passes through above-mentioned supervisor
The rear end on road is flow in chromatographic column.
Above-mentioned ph detector 21 can be set in the downstream of above-mentioned second surge tank 20 on above-mentioned main line, for supervising
The ph value of above-mentioned second eluent is surveyed, to obtain the ph value of accurate second eluent.
Above-mentioned second sample cock 21 can be set in the downstream of above-mentioned second surge tank 20 on above-mentioned main line, be used for
Sample above-mentioned second eluent flowed out from above-mentioned second surge tank 20.
Above-mentioned PLC electric control module (not being painted) is logical with above-mentioned second bye-pass and above-mentioned ph detector 21 respectively
Letter connection.Above-mentioned PLC electric control module is configurable to according to the second eluent received from above-mentioned ph detector 21
Real-time ph value, the supply of the above-mentioned hydrochloric acid solution of on-line control, to introduce closed-loop control.
It will be understood to those skilled in the art that above-mentioned ph adjusts the specific structure of solution supply module, only this implementation
A kind of preferred embodiment that example provides is mainly used for the hydrochloric acid solution in above-mentioned second storage tank 20 being supplied to above-mentioned main line,
And the supply of above-mentioned hydrochloric acid solution is adjusted by above-mentioned PLC electric control module, to adjust the ph value of above-mentioned second eluent.
In other embodiments, those skilled in the art can also adjust solution supply module using the ph of other structures, to realize
Hydrochloric acid solution in above-mentioned second storage tank 20 is supplied to the purpose of above-mentioned main line；Or using other electric-controlled moldings
Block, to obtain the effect for the supply for adjusting above-mentioned hydrochloric acid solution.
It will also be understood by those skilled in the art that adjusting solution as ph using hydrochloric acid solution, only the present embodiment is mentioned
A kind of concrete scheme supplied.In other embodiments, those skilled in the art can also be using other acid (ph < 7) or alkali
Property (ph > 7) solution, to realize the purpose for the ph value for adjusting above-mentioned second eluent.
The conductance of eluent is adjusted due to may be simultaneously present in the practical application of the liquid dispensing device of Column eluate
Rate, and adjust the demand of the ph value of eluent.The implementation of the liquid dispensing device of another Column eluate is also provided herein
Example.
It can simultaneously include the first two embodiment in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment
The conductivity of middle offer adjusts solution supply module and ph adjusts solution supply module.
As shown in figure 3, may include: first in the liquid dispensing device of above-mentioned Column eluate provided in this embodiment
Bye-pass and the second bye-pass.The front end connection conductivity of above-mentioned first bye-pass adjusts solution supply module.Above-mentioned second
The front end connection ph of pipeline adjusts solution supply module.
For adjusting the sodium chloride solution of conductivity, rear end is flowed to from the front end of above-mentioned first bye-pass, above-mentioned first
Above-mentioned main line is accessed so that above-mentioned sodium chloride solution to be delivered in above-mentioned main line in the rear end of pipeline.
For adjusting the hydrochloric acid solution of ph value, rear end, above-mentioned second bye-pass are flowed to from the front end of above-mentioned second bye-pass
Rear end access above-mentioned main line so that above-mentioned hydrochloric acid solution to be delivered in above-mentioned main line.
On above-mentioned main line, the on-position of above-mentioned second bye-pass rear end is in above-mentioned first bye-pass rear end access digit
The downstream set, the second static mixer 18 are located at the downstream of the first static mixer 13.
The conductivity that will lead to eluent since hydrochloric acid being added into sodium chloride solution increases, and sodium chloride solution is added
The ph value of eluent will not be then interfered into hydrochloric acid, it is this to first pass through above-mentioned conductivity adjusting solution supply module, using upper
The structure that ph adjusts solution supply module is stated, can accurately be realized molten to the amount and addition hydrochloric acid that need to be added sodium chloride solution
The control of the amount of liquid.
According to the real-time conductivity and real-time ph value of the eluent that feedback obtains, above-mentioned first metering pump 3 and above-mentioned is controlled
The flow of second metering pump 8 exports, and the conductivity of above-mentioned eluent and ph value can be made accurately stable in its target value.It is above-mentioned
The control precision of conductivity can achieve within ± 3%, and the control precision of above-mentioned ph value can achieve within ± 0.1.
After water in above-mentioned main line and above-mentioned sodium chloride solution converge, flow to the above-mentioned mixing of first static mixer 13 with
The first eluent is formed, after above-mentioned first eluent and above-mentioned hydrochloric acid solution converge, it is mixed to flow to above-mentioned second static mixer 18
It closes to form the second eluent, above-mentioned second eluent is flow in chromatographic column by the rear end of above-mentioned main line.
Electric conductivity detector 16 is set to the downstream of above-mentioned first static mixer 13 on above-mentioned main line, for supervising
Survey the conductivity of above-mentioned first eluent.Above-mentioned ph detector 21 is set to above-mentioned second static mixer on above-mentioned main line
18 downstream, with the ph value for monitoring above-mentioned second eluent.
Above-mentioned PLC electric control module is configurable to according to the real-time conductance received from above-mentioned electric conductivity detector 16
Rate and the target conductivity of operator's setting, the supply of the above-mentioned sodium chloride solution of on-line control, to introduce closed loop control
System.Above-mentioned PLC electric control module is also configured as according to the real-time ph value received from above-mentioned ph detector 21, Yi Jicao
Make the target ph of personnel setting, the supply of the above-mentioned hydrochloric acid solution of on-line control, to introduce closed-loop control.
It will be understood to those skilled in the art that adjusting solution supply module and above-mentioned using above-mentioned conductivity simultaneously
Ph adjusts the scheme of solution supply module, only a kind of preferred embodiment provided in this embodiment, for adjusting above-mentioned chromatography simultaneously
The conductivity and ph value of column eluent.In other embodiments, those skilled in the art can also further use and adjust it
The adjusting solution supply module of his target component, further to realize other targets for adjusting above-mentioned Column eluate simultaneously
The purpose of parameter；Or only with the adjusting solution supply module for adjusting other target components, above-mentioned chromatography is adjusted to be implemented separately
The purpose of other target components of column eluent.
Although for simplify explain the method is illustrated to and is described as a series of actions, it should be understood that and understand,
The order that these methods are not acted is limited, because according to one or more embodiments, some movements can occur in different order
And/or with from it is depicted and described herein or herein it is not shown and describe but it will be appreciated by those skilled in the art that other
Movement concomitantly occurs.
Offer is to make any person skilled in the art all and can make or use this public affairs to the previous description of the disclosure
It opens.The various modifications of the disclosure all will be apparent for a person skilled in the art, and as defined herein general
Suitable principle can be applied to other variants without departing from the spirit or scope of the disclosure.The disclosure is not intended to be limited as a result,
Due to example described herein and design, but should be awarded and principle disclosed herein and novel features phase one
The widest scope of cause.
Claims (10)
1. a kind of liquid dispensing device of Column eluate characterized by comprising
Main line, water flow to rear end from the front end of the main line；
Bye-pass, solution flow to rear end from the front end of the bye-pass, and the main line is accessed to incite somebody to action in the rear end of the bye-pass
The solution is delivered in the main line；
Static mixer, the static mixer are set on the main line, and the water in the main line and the solution converge
After conjunction, it flow to the static mixer and is mixed to form eluent, the eluent flow to layer by the rear end of the main line
It analyses in column；
Eluent detector, the eluent detector are set to the downstream of the static mixer on the main line, with
In the target component for monitoring the eluent；And
Electric control module, the electric control module are communicated to connect with the bye-pass and the eluent detector respectively,
The electric control module is configured to adjust the confession of the solution from the target component that the eluent detector receives
Ying Liang.
2. liquid dispensing device as described in claim 1, which is characterized in that the bye-pass includes the first bye-pass and the second branch pipe
Road, the solution include that conductivity adjusts solution and ph adjusting solution；
The conductivity adjusts solution and flows to rear end, the rear end access of first bye-pass from the front end of first bye-pass
The main line is conductivity adjusting solution to be delivered in the main line；
The ph adjusts solution and flows to rear end from the front end of second bye-pass；Described in the rear end access of second bye-pass
Main line is ph adjusting solution to be delivered in the main line；
On the main line, the rear end on-position of second bye-pass is in the rear end on-position of first bye-pass
Downstream；
The static mixer includes the first static mixer and the second static mixer, and second static mixer is located at institute
The downstream of the first static mixer is stated, the eluent includes the first eluent and the second eluent；
After water and conductivity adjusting solution in the main line converge, the first static mixer mixing is flow to shape
At the first eluent, after first eluent converges with ph adjusting solution, it flow to the second static mixer mixing
To form the second eluent, second eluent is flow in chromatographic column by the rear end of the main line；
The eluent detector includes electric conductivity detector and ph detector；
The electric conductivity detector is set to the downstream of first static mixer on the main line, with described for monitoring
The conductivity of eluent, the ph detector is set to the downstream of second static mixer on the main line, to be used for
Monitor the ph value of the eluent；
The electric control module is configured to the conductivity received from the electric conductivity detector and adjusts the conductivity
The supply of solution is adjusted, the electric control module is configured to described in the ph value received from the ph detector adjusting
The supply of ph adjusting solution.
3. liquid dispensing device as claimed in claim 2, which is characterized in that the liquid dispensing device further includes water supply module；
The water supply module includes water pump, inlet valve and flowing water Valve；
The water inlet of the water pump accesses water source of supply by the inlet valve, and the water outlet of the water pump passes through the water outlet
Valve accesses to the front end of the main line；
The water pump is used to for the water in the water source of supply being supplied to the main line, and the inlet valve is described for controlling
The opening and closing of the inlet pipeline formed between water source of supply and the water inlet of the water pump, the flowing water Valve is for controlling the water
The opening and closing of the outlet pipeline formed between the water outlet of pump and the front end of the main line；
The electric control module is also communicated to connect with the water supply module, and the electric control module is additionally configured to pass through institute
State the supply that water supply module adjusts the water.
4. liquid dispensing device as claimed in claim 3, which is characterized in that the water supply module further includes return line and water pump
Return valve；
The both ends of the return line are respectively connected on the inlet pipeline and the outlet pipeline, the water pump return valve
It is set on the return line, and the supply for adjusting the water.
5. liquid dispensing device as claimed in claim 2, which is characterized in that the liquid dispensing device further includes that conductivity adjusts solution confession
Answer module；
It includes the first storage tank, the first metering pump, first outlet pulse damper, that the conductivity, which adjusts solution supply module,
One delivery gauge and first outlet back pressure valve；
The entrance of first metering pump accesses to first storage tank, and the outlet of first metering pump passes sequentially through described
First outlet pulse damper, the first outlet pressure gauge and the first outlet back pressure valve access to first branch pipe
The front end on road；
First metering pump, which is used to the conductivity in first storage tank adjusting solution, passes through the first outlet pulse
Damper and the first outlet back pressure valve are supplied in first bye-pass；
It further includes the first safety line and the first safety-valve that the conductivity, which adjusts solution supply module,；
The both ends of first safety line are respectively connected to the outlet of first storage tank and first metering pump, described
First safety-valve is set in first safety line.
6. liquid dispensing device as claimed in claim 5, which is characterized in that the liquid dispensing device further include third static mixer and
First surge tank；
The third static mixer and first surge tank are respectively arranged on the main line, static mixed from described first
First eluent of clutch outflow flow to the third static mixer, described in third static mixer outflow
First eluent flow to first surge tank；
The liquid dispensing device further includes the first sample cock；
First sample cock is set on the main line, and for sampling the institute flowed out from first surge tank
State the first eluent.
7. liquid dispensing device as claimed in claim 2, which is characterized in that the liquid dispensing device further includes that ph adjusts solution supply mould
Block；
The ph adjusts solution supply module and goes out including the second storage tank, the second metering pump, second outlet pulse damper, second
Mouth pressure gauge and second outlet back pressure valve；
The entrance of second metering pump accesses to second storage tank, and the outlet of second metering pump passes sequentially through described
Second outlet pulse damper, the second outlet pressure gauge and the second outlet back pressure valve access to second branch pipe
The front end on road；
Second metering pump is used to the ph in second storage tank adjusting solution pulse damped by the second outlet
Device and the second outlet back pressure valve are supplied in second bye-pass；
It further includes the second safety line and the second safety-valve that the ph, which adjusts solution supply module,；
The both ends of second safety line are respectively connected to the outlet of second storage tank and second metering pump, described
Second safety-valve is set in second safety line.
8. liquid dispensing device as claimed in claim 7, which is characterized in that the liquid dispensing device further include the 4th static mixer and
Second surge tank；
4th static mixer and second surge tank are respectively arranged on the main line, static mixed from described second
Second eluent of clutch outflow flow to the 4th static mixer, described in the 4th static mixer outflow
Second eluent flow to second surge tank；
The liquid dispensing device further includes the second sample cock；
Second sample cock is set on the main line, and for sampling the institute flowed out from second surge tank
State the second eluent.
9. liquid dispensing device as claimed in claim 2, which is characterized in that the liquid dispensing device further include outlet electromagnetic flowmeter and
Outlet pressure transmitter；
The outlet electromagnetic flowmeter and the outlet pressure transmitter are respectively arranged on the rear end of the main line, and point
It is not communicated to connect with the electric control module；
The outlet electromagnetic flowmeter is used to monitor the flow value of the rear end of the main line；
The outlet pressure transmitter is used to monitor the pressure value of the rear end of the main line；
The liquid dispensing device further includes into column tube road, into column valve door, discharging of waste liquid pipeline and discharging of waste liquid valve；
It is described into column valve door include into column manually-operated gate and into column electromagnetic valve；
The discharging of waste liquid valve includes discharging of waste liquid manually-operated gate and discharging of waste liquid electromagnetic valve；
Described into column valve door and when closing the discharging of waste liquid valve when opening, the rear end of the main line accesses to described into column
The front end of pipeline, the rear end into column tube road access in the chromatographic column, and second eluent is delivered to institute
It states in chromatographic column；
Described into column valve door and when opening the discharging of waste liquid valve when closing, the rear end of the main line accesses to the waste liquid
Discharge pipe connection, the discharging of waste liquid pipeline are used to discharge second eluent of the main line conveying.
10. the liquid dispensing device as described in any one of claim 2~9, which is characterized in that the water includes deionized water；
And/or
It includes sodium chloride solution that the conductivity, which adjusts solution,；And/or
It includes hydrochloric acid solution that the ph, which adjusts solution,；And/or
The electric control module includes PLC.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811561735.6A CN109453545A (en) | 2018-12-20 | 2018-12-20 | The liquid dispensing device of Column eluate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811561735.6A CN109453545A (en) | 2018-12-20 | 2018-12-20 | The liquid dispensing device of Column eluate |
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| Publication Number | Publication Date |
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| CN109453545A true CN109453545A (en) | 2019-03-12 |
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ID=65614134
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811561735.6A Pending CN109453545A (en) | 2018-12-20 | 2018-12-20 | The liquid dispensing device of Column eluate |
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| CN (1) | CN109453545A (en) |
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| CN109917035A (en) * | 2019-03-22 | 2019-06-21 | 肖传绪 | Washing device and application thereof with drop measurement function |
| CN113018906A (en) * | 2020-12-08 | 2021-06-25 | 南京赛思昂智控科技有限公司 | Intelligent column chromatography system |
| CN115282865A (en) * | 2022-08-03 | 2022-11-04 | 安徽灿实生物工程有限公司 | Online liquid machine of joining in marriage of buffer solution |
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