CN109453278A - A kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof - Google Patents
A kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof Download PDFInfo
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- CN109453278A CN109453278A CN201811589795.9A CN201811589795A CN109453278A CN 109453278 A CN109453278 A CN 109453278A CN 201811589795 A CN201811589795 A CN 201811589795A CN 109453278 A CN109453278 A CN 109453278A
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- 239000002245 particle Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000002671 adjuvant Substances 0.000 claims abstract description 21
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims abstract description 18
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims abstract description 18
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 18
- 239000009136 dragon's blood Substances 0.000 claims abstract description 18
- 241000255791 Bombyx Species 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 16
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940116229 borneol Drugs 0.000 claims abstract description 16
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 16
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000004006 olive oil Substances 0.000 claims abstract description 16
- 235000008390 olive oil Nutrition 0.000 claims abstract description 16
- 229920002261 Corn starch Polymers 0.000 claims abstract description 15
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 15
- 239000008120 corn starch Substances 0.000 claims abstract description 15
- 229940099112 cornstarch Drugs 0.000 claims abstract description 15
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 206010046914 Vaginal infection Diseases 0.000 claims abstract description 7
- 201000008100 Vaginitis Diseases 0.000 claims abstract description 7
- 239000011347 resin Substances 0.000 claims description 19
- 229920005989 resin Polymers 0.000 claims description 19
- VCCRNZQBSJXYJD-UHFFFAOYSA-N galangin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=CC=C1 VCCRNZQBSJXYJD-UHFFFAOYSA-N 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 8
- CIPSYTVGZURWPT-UHFFFAOYSA-N galangin Natural products OC1=C(Oc2cc(O)c(O)cc2C1=O)c3ccccc3 CIPSYTVGZURWPT-UHFFFAOYSA-N 0.000 claims description 8
- SUYJZKRQHBQNCA-UHFFFAOYSA-N pinobanksin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=CC=C1 SUYJZKRQHBQNCA-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 238000010828 elution Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 241000255789 Bombyx mori Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- 244000296102 Selinum monnieri Species 0.000 claims 1
- 235000019084 Selinum monnieri Nutrition 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 239000003814 drug Substances 0.000 abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 4
- 206010067484 Adverse reaction Diseases 0.000 abstract description 3
- 230000006838 adverse reaction Effects 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000008506 pathogenesis Effects 0.000 abstract description 2
- 230000035699 permeability Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 8
- 239000001963 growth medium Substances 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013882 gravy Nutrition 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 241000191992 Peptostreptococcus Species 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- LPNITZFOZWXKMB-UHFFFAOYSA-N acetic acid;molecular chlorine Chemical compound ClCl.CC(O)=O LPNITZFOZWXKMB-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229940071110 amino-cerv Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 206010008323 cervicitis Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 210000004999 sex organ Anatomy 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61P31/04—Antibacterial agents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention discloses a kind of external application bacteriostatic Chinese medicinal particles and preparation method thereof, including following raw material: kuh-seng, Cortex Phellodendri, wild chrysanthemum, dragon's blood, bombyx batryticatus, frutus cnidii, borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant, existing gynecologic medicine is solved to have a single function, material base is unclear, there are adverse reactions, there are side effects, the problems such as effect is unobvious, according to vaginitis at Anttdisease Mechanism, targetedly medication, under the guidance of traditional Chinese medical theory, diagnosis and treatment based on an overall analysis of the illness and the patient's condition, proportion prescription is carried out in conjunction with the pathogenesis and disease symptom of vaginitis, improve the permeability of blood vessel, it promotes blood circulation, enhance bacteriostasis；Unused preparation method is used according to the characteristic of different pharmaceutical, effective component therein can sufficiently be extracted；It can fundamentally be reconciled, be had no toxic side effect from human body, it is efficient high, it is practical；Have effects that simultaneously antibacterial and two kinds of health care.
Description
Technical field
The invention belongs to Amino-Cerv technical fields, and in particular to a kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof.
Background technique
Currently, female vagina, cervicitis, adnexitis etc. are the common and multiple diseases of middle aged and aged women, are directly affected
The body and mind Jiankang of women and love life also will affect U.S. face, lead to premature aging occur.Due to the spy of female sex organ
Different property, gynaecological imflammation have become common, the frequently-occurring disease of adult female, and clinical manifestation is varied, and the cause of disease is complicated and is often accompanied by
A variety of Complicated with Severe diseases, have a significant impact to the life and work of women.
Antibacterial medicines currently used for gynaecology are many kinds of, but most of antibacterial medicines are with acidic disinfectant by one
Determine the product that concentration requires production, such drug, which is used for a long time, to be caused to damage to vagina skin and mucous membrane, or even causes tissue
Hyperplasia.Simultaneously it is indefinite to there is big inconvenient for use, dosage, complicated component, active component more in compound medicine, and now very much
Drug only has restraining and sterilizing bacteria effect, and a subsequent health care can not be played to vagina and restitution, effect are single；It is risen in compound
The problems such as material base of curative effect is unclear, and there are certain adverse reactions；Therefore develop it is a kind of for vaginitis, effectively
Clear, curative for effect, Small side effects the bacteriostasis and health-care drug of substance is the task of top priority.
Summary of the invention
The present invention provides a kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof, solves existing gynecological drug in background technique
Object has a single function, and material base is unclear, there are adverse reaction, there are side effect, and the problems such as effect is unobvious.
Specific technical solution is as follows:
A kind of external application bacteriostatic Chinese medicinal particle, the raw material including following parts by weight: 15-35 parts of kuh-seng, 10-20 parts of Cortex Phellodendri,
15-20 parts of wild chrysanthemum, 15-20 parts of dragon's blood, 10-20 parts of bombyx batryticatus, 10-20 parts of frutus cnidii, 5-12 parts of borneol, cornstarch 25-40
Part, 7-16 parts of chlorhexidine acetate, 40-55 parts of water, 3-8 parts of olive oil, 5-8 parts of adjuvant.
Preferably, the raw material including following parts by weight: 25 parts of kuh-seng, 15 parts of Cortex Phellodendri, 15 parts of wild chrysanthemum, 17 parts of dragon's blood,
15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch, 7 parts of chlorhexidine acetate, 45 parts of water, 5 parts of olive oil, auxiliary
7 parts of agent.
Preferably, the adjuvant are as follows: the mixture of 2-acetylamino-2-deoxy-D-glucose and Galangin, wherein N- acetyl-
2-7 parts of D- Glucosamine, 3-10 parts of Galangin.
A kind of preparation method of external application bacteriostatic Chinese medicinal particle, comprising the following steps: kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned and dried
It is dry, it crushes, the 4-5 times of water measured mixing is added, extracts 3-4 times, obtains extracting solution, be concentrated and dried, obtain dried object A；It takes
Wild chrysanthemum, the dragon's blood, bombyx batryticatus of corresponding number, add water to cook 4-6h, are centrifuged 20min；Supernatant is taken to carry out using adsorption resin column
Purification process first with the water washing of 1~10 times of resin column volume, then with 1~10 times of resin column volume, concentration is 50~90%
Ethanol elution, concentration, it is dry, obtain dried object B；By dried object A and dried object B and borneol, cornstarch, acetic acid chlorine oneself
Fixed, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care particle is made.
Preferably, after kuh-seng, Cortex Phellodendri, frutus cnidii being cleaned dries pulverizing, 300-500 mesh is crossed.
Preferably, when extracting to dried object A, Extracting temperature is 95-100 DEG C.
Preferably, used revolving speed is 3000-5000r/min when being centrifuged to wild chrysanthemum, dragon's blood, bombyx batryticatus.
Preferably, if the described in any item external application bacteriostasis and health-care particles of claim 1-7 are in terms of preventing and treating gynaecological imflammation
Using；The gynaecological imflammation is vaginitis.
The utility model has the advantages that
For the present invention according to vaginitis at Anttdisease Mechanism, targetedly medication is dialectical to apply under the guidance of traditional Chinese medical theory
It controls, carries out proportion prescription in conjunction with the pathogenesis and disease symptom of vaginitis, improve the permeability of blood vessel, promote blood circulation,
Enhance bacteriostasis；In the preparation, kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned into drying, crushed, the 4-5 times of water measured mixing is added,
It extracts 3-4 times, obtains extracting solution, be concentrated and dried, obtain dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number, add
Water decocts centrifugation；Supernatant is taken to carry out purification process using adsorption resin column, elution, concentration are dry, obtain dried object B；It will do
Dry object A is uniformly mixed with dried object B and borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant, is crushed, is made
Finished product bacteriostasis and health-care particle uses unused preparation method according to the characteristic of different pharmaceutical, can be by effective component therein
Sufficiently extract；It can fundamentally be reconciled, be had no toxic side effect from human body, it is efficient high, it is practical；Simultaneously have it is antibacterial and
Two kinds of effects of health care.
Specific embodiment
Embodiment 1:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 15 parts of kuh-seng, 10 parts of Cortex Phellodendri,
20 parts of wild chrysanthemum, 16 parts of dragon's blood, 17 parts of bombyx batryticatus, 13 parts of frutus cnidii, 8 parts of borneol, 40 parts of cornstarch, 9 parts of chlorhexidine acetate, water
41 parts, 8 parts of olive oil, 6 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 2 parts of 2-acetylamino-2-deoxy-D-glucose, 10 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 300 meshes, and the water mixing of 5 times of amounts is added, extracts 3 times, and Extracting temperature is 96 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4h, are centrifuged 20min, revolving speed
For 3500r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 1 times of resin column volume, then uses
8 times of resin column volumes, the ethanol elution that concentration is 50%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 2:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 25 parts of kuh-seng, 15 parts of Cortex Phellodendri,
15 parts of wild chrysanthemum, 17 parts of dragon's blood, 15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch, 7 parts of chlorhexidine acetate, water
45 parts, 5 parts of olive oil, 7 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 5 parts of 2-acetylamino-2-deoxy-D-glucose, 7 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 400 meshes, and the water mixing of 4 times of amounts is added, extracts 3 times, and Extracting temperature is 95 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4h, are centrifuged 20min, revolving speed
For 5000r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 4 times of resin column volumes, then uses
6 times of resin column volumes, the ethanol elution that concentration is 90%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 3:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 30 parts of kuh-seng, 20 parts of Cortex Phellodendri,
17 parts of wild chrysanthemum, 20 parts of dragon's blood, 16 parts of bombyx batryticatus, 15 parts of frutus cnidii, 12 parts of borneol, 25 parts of cornstarch, 16 parts of chlorhexidine acetate,
50 parts of water, 3 parts of olive oil, 5 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 6 parts of 2-acetylamino-2-deoxy-D-glucose, 4 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 500 meshes, and the water mixing of 4 times of amounts is added, extracts 4 times, and Extracting temperature is 97 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 5h, are centrifuged 20min, revolving speed
For 4000r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 7 times of resin column volumes, then uses
5 times of resin column volumes, the ethanol elution that concentration is 60%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 4:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 35 parts of kuh-seng, 17 parts of Cortex Phellodendri,
16 parts of wild chrysanthemum, 15 parts of dragon's blood, 20 parts of bombyx batryticatus, 20 parts of frutus cnidii, 5 parts of borneol, 27 parts of cornstarch, 10 parts of chlorhexidine acetate,
40 parts of water, 7 parts of olive oil, 8 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 5 parts of 2-acetylamino-2-deoxy-D-glucose, 5 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 350 meshes, and the water mixing of 5 times of amounts is added, extracts 4 times, and Extracting temperature is 100 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 6h, are centrifuged 20min, revolving speed
For 3000r/min；Supernatant is taken to carry out purification process using adsorption resin column, first with the water washing of 10 times of resin column volumes, then
It is dry with 1 times of resin column volume, the ethanol elution that concentration is 80%, concentration, obtain dried object B；By dried object A and dried object B
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Bacteriostatic test
Test material: embodiment 1, embodiment 2, embodiment 3, embodiment 4 and comparative example 1 are (commercially available commonly to have antibacterial work
The antibacterial particle of gynaecology).For trying bacterial species: peptostreptococcus number, vagina Gartner bacterium, staphylococcus aureus.Bacterium
Culture medium: bacteria culture media is Tryptose soy broth bouillon；Preparation method are as follows: Tryptose soy gravy powder 30g, basic fine jade
The rouge 15g plus raw water 1L that reduces phlegm and internal heat that sterilizes.Inoculum: inoculum is 3% Tryptose soy meat soup 200mL.Preparation method
Are as follows: Tryptose soy gravy powder 6g adds sterilizing to reduce phlegm and internal heat raw water 200mL.Test method: using diffusion method, and every kind of antibacterial particle is with going out
The dissolution of bacterium pyrogen removal water, obtained solution.Inoculum uniform crossover is applied on the culture medium of culture dish, culture dish is placed in
In 37 DEG C of constant temperature incubator for 24 hours, each 10, culture dish for cultivating every kind of bacterium, it is respectively that 5 kinds of each 50mg of experimental solutions are uniform
Be coated on roundlet filter paper, in addition, respectively the 10 μ L capillary burette equivalent of raw water of reducing phlegm and internal heat of experimental solutions and sterilizing drip in
On roundlet filter paper.It by 3 roundlet filter papers for being stained with experimental solutions of the same race and is stained with sterilizing again and reduces phlegm and internal heat 3 roundlets of raw water
Filter paper symmetrically is attached at the middle section on culture medium, is detected on every kind of bacteria culture media.It finally will training
Feeding ware, which is placed in 37 DEG C of constant temperature incubator, to be cultivated for 24 hours, is measured antibacterial circle diameter (bacteriostatic diameter mm meter), and test is repeated 5 times, with
5 average values are antibacterial circle diameter.
As can be seen from the above table, the bacteriostasis and health-care particle being prepared by the present invention has good bacteriostasis efficacy, suppression
Bacterium loop diameter is significantly greater than comparative example, this shows the unused preparation method that the present invention is used according to the characteristic of different pharmaceutical,
Effective component therein can sufficiently be extracted, fundamentally be reconciled, had no toxic side effect from human body, efficient high, practicability
By force.
Obviously present invention specific implementation is not subject to the restrictions described above, as long as using method concept and skill of the invention
The improvement for the various unsubstantialities that art scheme carries out, or not improved the conception and technical scheme of the invention are directly applied to it
Its occasion, within that scope of the present invention.
Claims (8)
1. a kind of external application bacteriostatic Chinese medicinal particle, which is characterized in that the raw material including following parts by weight: 15-35 parts of kuh-seng, Cortex Phellodendri
10-20 parts, 15-20 parts of wild chrysanthemum, 15-20 parts of dragon's blood, 10-20 parts of bombyx batryticatus, 10-20 parts of frutus cnidii, 5-12 parts of borneol, corn shallow lake
25-40 parts of powder, 7-16 parts of chlorhexidine acetate, 40-55 parts of water, 3-8 parts of olive oil, 5-8 parts of adjuvant.
2. external application bacteriostasis and health-care particle as described in claim 1, which is characterized in that the raw material including following parts by weight: bitter
Ginseng 25 parts, 15 parts of Cortex Phellodendri, 15 parts of wild chrysanthemum, 17 parts of dragon's blood, 15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch,
7 parts of chlorhexidine acetate, 45 parts of water, 5 parts of olive oil, 7 parts of adjuvant.
3. external application bacteriostasis and health-care particle as described in claim 1, which is characterized in that the adjuvant are as follows: N- acetyl-D-amino
The mixture of glucose and Galangin, wherein 2-acetylamino-2-deoxy-D-glucose 2-7 parts, 3-10 parts of Galangin.
4. a kind of preparation method of external application bacteriostatic Chinese medicinal particle, which comprises the following steps:
Kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned into drying, crushed, the 4-5 times of water measured mixing is added, extracts 3-4 times, obtains extracting solution,
It is concentrated and dried, obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4-6h, are centrifuged 20min；
Supernatant is taken to carry out purification process using adsorption resin column, first with the water washing of 1~10 times of resin column volume, then with 1~10 times
Resin column volume, the ethanol elution that concentration is 50~90%, concentration, it is dry, obtain dried object B；By dried object A and dried object B
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
5. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that by kuh-seng, Cortex Phellodendri, cnidium monnieri
After the clean dries pulverizing of son, 300-500 mesh is crossed.
6. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that mentioned to dried object A
When taking, Extracting temperature is 95-100 DEG C.
7. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that wild chrysanthemum, dragon's blood, deadlock
Used revolving speed is 3000-5000r/min when silkworm is centrifuged.
8. such as the described in any item external application bacteriostasis and health-care particles of claim 1-7, which is characterized in that in terms of preventing and treating gynaecological imflammation
Application；The gynaecological imflammation is vaginitis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559427A (en) * | 2019-10-28 | 2019-12-13 | 田兰 | Traditional Chinese medicine biological preparation for promoting female reproductive system to expel toxin and preparation method thereof |
| CN111000927A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Antibacterial lotion for female vulva and preparation method thereof |
| CN111617166A (en) * | 2020-06-29 | 2020-09-04 | 藏寿堂健康管理(武汉)有限公司 | Plant-extracted anorectal bacteriostatic product and preparation process thereof |
| CN111888406A (en) * | 2019-05-06 | 2020-11-06 | 河北环兴保健食品有限公司 | Chinese medicine preparation widely used for epidermic inflammation and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991519A (en) * | 2010-11-01 | 2011-03-30 | 江西中兴汉方药业有限公司 | Bacteriostatic lotion and preparation method thereof |
| AU2016270753A1 (en) * | 2015-06-01 | 2017-11-16 | Durga Enterprises, LLC | Compositions for treatment of atrophic vaginitis, peri-and post-menopausal dyspareunia, and/or oophorectomized females and treatment methods therewith |
| CN108567870A (en) * | 2018-07-25 | 2018-09-25 | 博凯健康产业有限公司 | Clean maintenance particle of woman and preparation method thereof, application method and application |
-
2018
- 2018-12-25 CN CN201811589795.9A patent/CN109453278A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991519A (en) * | 2010-11-01 | 2011-03-30 | 江西中兴汉方药业有限公司 | Bacteriostatic lotion and preparation method thereof |
| AU2016270753A1 (en) * | 2015-06-01 | 2017-11-16 | Durga Enterprises, LLC | Compositions for treatment of atrophic vaginitis, peri-and post-menopausal dyspareunia, and/or oophorectomized females and treatment methods therewith |
| CN108567870A (en) * | 2018-07-25 | 2018-09-25 | 博凯健康产业有限公司 | Clean maintenance particle of woman and preparation method thereof, application method and application |
Non-Patent Citations (2)
| Title |
|---|
| 中康健购: "你知道吗？女性子宫最怕这6件事！呵护子宫先看白带！", 《百度》 * |
| 何昌善 等: "《临症用药纲目》", 31 August 2017, 中国医药科技出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888406A (en) * | 2019-05-06 | 2020-11-06 | 河北环兴保健食品有限公司 | Chinese medicine preparation widely used for epidermic inflammation and preparation method thereof |
| CN110559427A (en) * | 2019-10-28 | 2019-12-13 | 田兰 | Traditional Chinese medicine biological preparation for promoting female reproductive system to expel toxin and preparation method thereof |
| CN111000927A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Antibacterial lotion for female vulva and preparation method thereof |
| CN111617166A (en) * | 2020-06-29 | 2020-09-04 | 藏寿堂健康管理(武汉)有限公司 | Plant-extracted anorectal bacteriostatic product and preparation process thereof |
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