CN109441754A - A kind of microfluidic system and its micro-fluidic fluid drive apparatus - Google Patents
A kind of microfluidic system and its micro-fluidic fluid drive apparatus Download PDFInfo
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- CN109441754A CN109441754A CN201811331709.4A CN201811331709A CN109441754A CN 109441754 A CN109441754 A CN 109441754A CN 201811331709 A CN201811331709 A CN 201811331709A CN 109441754 A CN109441754 A CN 109441754A
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- China
- Prior art keywords
- caisson
- micro
- drive apparatus
- regulator valve
- pressure regulator
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
- F04B9/08—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid
- F04B9/12—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
- F04B49/22—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00 by means of valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Micromachines (AREA)
Abstract
The invention discloses a kind of microfluidic system and its micro-fluidic fluid drive apparatus, which includes caisson and pressure regulator valve, wherein caisson is for storing high pressure gas；The first end of pressure regulator valve and the gas outlet seal of caisson are cooperatively connected, and second end is provided with for the outlet nozzle with pipeline connection；In application, whole system provides high pressure gas by caisson, and the size of the control fluid drive apparatus outlet pressures of the pressure regulator valve by being connected with caisson, due to having certain gas reserves in caisson, after pressure regulator valve controls, stable high pressure gas output can be provided within a certain period of time, and then the flowing for being fluid in microchip provides the power of long-time stable, due to not needing to be connected to more complicated external equipment when caisson work, whole system is desirably integrated into small volume space, possibility is provided for the portability of whole equipment.
Description
Technical field
The present invention relates to microfluidic art, in particular to a kind of microfluidic system and its micro-fluidic fluid driving dress
It sets.
Background technique
Currently, many technologies relevant to PCR amplification, which require power device (pump), provides the power of fluid motion, such as
Drop formation device in digital pcr equipment, main working process pushes oil mutually using power device or water phase is in microchannel
The interior digital drop for forming small (nanoliter~picoliters rank)；For another example real-time fluorescence quantitative PCR amplification is realized inside microchannel
Technology, require pump and carry out Fluid Motion Driven By Moving, and then realize that complicated temperature cycles realize the amplification of nucleic acid molecules.
Generally speaking, liquid can be realized in microchannel internal flow by needing to apply fluid power, these power are logical
Often from based on pump made of various principles.Currently used pump can be divided into two major classes: one kind is driven by extra power
Dynamic pump, such as syringe pump, rotary pump, electromagnetic pump etc.；Another kind of is the pump not against extra power driving, such as utilizes gravity, table
Face tension, gas pressure etc. drive the pump of liquid flowing.The pump driven using extra power, can not get rid of to external equipment according to
Rely, therefore the volume of system is often very big.And many pumps for not using extra power to drive, there are flow control is uneven, stream
The dynamic time is short, the small problem of flow.
Summary of the invention
In view of this, one of core of the present invention is to provide a kind of micro-fluidic fluid drive apparatus, to reach miniature portable,
It realizes to fluid for a long time, the purpose of the stability contorting of big flow.
Another core of the invention is to provide a kind of microfluidic system based on above-mentioned micro-fluidic fluid drive apparatus.
To achieve the above object, the invention provides the following technical scheme:
A kind of micro-fluidic fluid drive apparatus, comprising:
For storing the caisson of high pressure gas；
The gas outlet seal of pressure regulator valve, the first end of the pressure regulator valve and the caisson is cooperatively connected, the pressure regulation
The second end of valve is provided with for the outlet nozzle with pipeline connection.
Preferably, the caisson includes inflatable structure.
Preferably, the caisson includes cylinder, preceding sealing cover and rear sealing cover, the preceding sealing cover and described
Sealing cover is set in the cylinder and surrounds the gas storage cavity for storing high pressure gas, the pressure regulator valve with the cylinder afterwards
First end and the cylinder be engaged by clamping, and the air inlet of the pressure regulator valve be formed in the outlet of the preceding sealing cover
Mouth docks, and the inflating port for inflation is formed on the rear sealing cover and/or the cylinder.
Preferably, the caisson includes replaceable gas cylinder, and the replaceable gas cylinder and the pressure regulator valve are removable
Unload connection.
Preferably, the caisson further include:
One end is provided with the pressure regulation valve housing, and tank, described tank one end and the tune are formed in the shell
The air inlet of pressure valve is connected to, and the other end is formed with for the opening for the replaceable gas cylinder disengaging；
The end cap being spirally connected with the other end of the shell holds out against the replaceable gas cylinder.
A kind of microfluidic system, comprising:
Micro-fluidic fluid drive apparatus described in any one as above；
Oil storage bottle, the oil storage bottle are connected by the gas outlet of tracheae and the pressure regulator valve of the micro-fluidic fluid drive apparatus
It is logical；
The chip being connected to by delivery pipe with the oil storage bottle, the micro-fluidic fluid drive apparatus is by tracheae to described
Oil storage bottle inputs high pressure gas to drive the oil in the oil storage bottle to flow into the chip through the delivery pipe.
Preferably, the delivery pipe is detachably connected with the oil storage bottle, and the delivery pipe is fixedly connected with the chip.
Preferably, the delivery pipe includes sample cell, and the sample cell includes main paragraph and sample segments, the main paragraph
Both ends connect respectively with the oil storage bottle and the chip, the sample segments are detachably connected with the main paragraph.
Preferably, the delivery pipe further includes petroleum pipeline, the outlet of the outlet end of the petroleum pipeline and the sample cell
End is connected in parallel on the arrival end of the chip.
Preferably, the outlet end of the chip is provided with the capillary being adjusted for the flow velocity to liquid in the chip
Quartz ampoule.
It can be seen from the above technical scheme that micro-fluidic fluid drive apparatus provided by the invention, including caisson
And pressure regulator valve, wherein caisson is for storing high pressure gas；The first end of pressure regulator valve and the gas outlet seal of caisson
It is cooperatively connected, second end is provided with for the outlet nozzle with pipeline connection；In use, whole system provides height by caisson
It calms the anger body, and the size of the control fluid drive apparatus outlet pressures of the pressure regulator valve by being connected with caisson, due to gas storage
Have certain gas reserves in device, after pressure regulator valve controls, stable high pressure gas can be provided within a certain period of time
Output, and then the flowing for be fluid in microchip provides the power of long-time stable, due to not needed when caisson works
It is connected to more complicated external equipment, whole system is desirably integrated into small volume space, is the portability of whole equipment
There is provided may.
The present invention also provides a kind of microfluidic systems based on above-mentioned micro-fluidic fluid drive apparatus, due to micro-fluidic system
System uses above-mentioned micro-fluidic fluid drive apparatus, and micro-fluidic fluid drive apparatus has above-mentioned technique effect, therefore, should
Microfluidic system should also have corresponding technical effect, and details are not described herein.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the structural schematic diagram for the micro-fluidic fluid drive apparatus that an embodiment of the present invention provides；
Fig. 2 is the structural schematic diagram for the micro-fluidic fluid drive apparatus that another embodiment of the present invention provides；
Fig. 3 is the structural schematic diagram of microfluidic system provided in an embodiment of the present invention.
In figure:
1 is caisson；111 be preceding sealing cover；112 be cylinder；113 be rear sealing cover；121 be shell；122 be appearance
Slot；123 be replaceable gas cylinder；124 be end cap；2 be pressure regulator valve；3 be tracheae；4 be oil storage bottle；5 be sample cell；Based on 501
Body section；502 be sample segments；6 be petroleum pipeline；7 be chip；8 be capillary quartz ampoule.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Micro-fluidic fluid drive apparatus provided in an embodiment of the present invention, including caisson 1 and pressure regulator valve 2.
Wherein, caisson 1 is for storing high pressure gas；The first end of pressure regulator valve 2 and the gas outlet seal of caisson 1
It is cooperatively connected, second end is provided with for the outlet nozzle with pipeline connection；In use, whole system is provided by caisson 1
High pressure gas, and the size of the control fluid drive apparatus outlet pressures of the pressure regulator valve 2 by being connected with caisson 1.
It can be seen from the above technical scheme that compared with prior art, micro-fluidic fluid provided in an embodiment of the present invention
Driving device, can be within a certain period of time after the control of pressure regulator valve 2 due to having certain gas reserves in caisson 1
Stable high pressure gas output is provided, and then the flowing for be fluid in microchip 7 provides the power of long-time stable, due to storing up
Device of air 1 does not need to be connected to more complicated external equipment when working, and whole system is desirably integrated into small volume space,
Possibility is provided for the portability of whole equipment.
Caisson 1 can use various structures, for example the inflatable structure that can inflate reuse repeatedly can be used, or
Person is using the structure of disposable replaceable gas cylinder, and as shown in FIG. 1, FIG. 1 is the micro-fluidic fluids that an embodiment of the present invention provides
The structural schematic diagram of driving device, in this embodiment, caisson 1 is using inflatable structure.
Specifically, caisson 1 includes cylinder 112, preceding sealing cover 111 and rear sealing cover 113, preceding sealing cover 111 with
And rear sealing cover 113 is set in cylinder 112 and surrounds the gas storage cavity for storing high pressure gas, pressure regulator valve 2 with cylinder 112
First end and cylinder 112 be engaged by clamping, and the air inlet of pressure regulator valve 2 is docked with the gas outlet for being formed in preceding sealing cover 111, after
The inflating port for inflation is formed on sealing cover 113 and/or cylinder 112.
Further, as shown in Figure 1, in the above-described embodiments, inflating port is set to rear sealing cover 113, and at inflating port
It is provided with Aerating needle and spring, the first end of Aerating needle passes through rear sealing cover 113 and protrudes into gas storage cavity, and in the work of spring
Under, the conical surface of the first end of Aerating needle and the conical surface close fitting seal on rear sealing cover 113, when the second end to Aerating needle
When applying external force, Aerating needle overcomes the elastic force of spring to move into gas storage cavity, the conical surface of the first end of Aerating needle and rear sealing
Conical surface separation on lid 113, forms gap between Aerating needle and rear sealing cover 113, in order to deflate or inflate.
Certainly, caisson 1 can also be using other structures, referring to Fig. 2, Fig. 2 is another embodiment of the present invention
The structural schematic diagram of the micro-fluidic fluid drive apparatus provided, caisson 1 include replaceable gas cylinder 123, replaceable gas
Bottle 123 is detachably connected with pressure regulator valve 2, can be replaceable with others after the high pressure gas in replaceable gas cylinder 123 releases
Formula gas cylinder 123 is replaced, and the replaceable gas cylinder 123 displaced can continue inflation and reuse or directly abandon.
Above-mentioned technical proposal is advanced optimized, for the fixation convenient for replaceable gas cylinder 123, in the above-described embodiments, storage
Device of air 1 further includes shell 121 and end cap 124, wherein 121 one end of shell is provided with pressure regulator valve 2, is formed in shell 121
For accommodating the tank 122 of replaceable gas cylinder 123,122 one end of tank is connected to the air inlet of pressure regulator valve 2, and the other end is formed
Have for the opening for the disengaging of replaceable gas cylinder 123；End cap 124 and the other end of shell 121 are spirally connected, by replaceable gas
Bottle 123 is held out against, and when in use, replaceable gas cylinder 123 is inserted into tank 122 first, is then gradually screwed end cap 124 with solid
Fixed replaceable gas cylinder 123.
Based on above-mentioned micro-fluidic fluid drive apparatus, the embodiment of the invention also provides a kind of microfluidic systems, such as Fig. 3 institute
Show, which includes oil storage bottle 4, chip 7 and micro-fluidic fluid drive apparatus described in any one as above；Oil storage
Bottle 4 is connected to by tracheae 3 with the gas outlet of the pressure regulator valve 2 of micro-fluidic fluid drive apparatus；Chip 7 passes through delivery pipe and oil storage bottle
4 connections, micro-fluidic fluid drive apparatus input high pressure gas to oil storage bottle 4 to drive the oil in oil storage bottle 4 through defeated by tracheae 3
Pipe is sent to flow into chip 7.Since the microfluidic system uses above-mentioned micro-fluidic fluid drive apparatus, then microfluidic system has
Beneficial effect please refers to above-described embodiment.As shown in figure 3, in this embodiment, oil storage bottle 4 is centrifuge tube.Certain oil storage bottle 4 can also
To use other structures.
For convenient for oil liquid is perfused into oil storage bottle 4, in embodiments of the present invention, delivery pipe is detachably connected with oil storage bottle 4,
Delivery pipe is fixedly connected with chip 7.
Preferably, as shown in figure 3, delivery pipe includes sample cell 5, sample cell 5 includes main paragraph 501 and sample segments
502, the both ends of main paragraph 501 are connect with oil storage bottle 4 and chip 7 respectively, and sample segments 502 are detachably connected with main paragraph 501.
Further, as shown in figure 3, delivery pipe further includes petroleum pipeline 6, the outlet end of petroleum pipeline 6 and going out for sample cell 5
Mouth end is connected in parallel on the arrival end of chip 7.
In use, firstly, take 4ml centrifuge tube as oil storage bottle 4,3 2mm circular holes of drill with ferrule on centrifuge tube lid, to
The oily phase of HFE 7500 of the inner filling 2/3 of oil storage bottle 4, then the Teflon pipe of 3 root canal diameter 1mm × 2mm is inserted into oil storage bottle 4,
In one, for connecting the gas outlet of pressure regulator valve 2, in addition two are inserted into pasta bottom more than pasta, for as conveying
Pipe.In the process, it is good by the clearance seal between 4 lid of oil storage bottle and pipe with glue to need.
Two Teflon pipes are connected to the oil of chip 7 mutually and water phase inlet, blend compounds are sealed entrance, and with injecting
Device is into 7 pipeline of chip full of oily phase.
Secondly, taking the silicone tube of two root canal diameter 2mm × 4mm as sample cell 5 and petroleum pipeline 6, extracted with syringe interval
It is oily mutually to inject sample cell 5 with different sample reagents, and oily phase is injected into petroleum pipeline 6 with syringe.
Finally, the other end of three root canals of oil storage bottle 4 is connected respectively to the gas outlet of pressure regulator valve 2, sample cell 5 and oil transportation
The other end of sample cell 5 and petroleum pipeline 6 is connected respectively to the Teflon that is connected with 7 oil phase of chip and water phase pipeline by one end of pipe 6
One end of pipe, whole system are just completed.
When work, adjusting pressure regulator valve 2 makes high pressure gas enter oil storage bottle 4, and liquid is pushed to flow in pipeline, steady to system
Stabilization flow velocity of the fluid in chip 7 can be obtained after fixed, pressure size is adjusted by pressure regulator valve 2, can control liquid in pipe
Flowing velocity inside road.
Above-mentioned technical proposal is advanced optimized, in embodiments of the present invention, the outlet end of chip 7 is provided with for chip
The capillary quartz ampoule 8 that the flow velocity of liquid is adjusted in 7 can change 7 arrival end of chip by pressure regulator valve 2 in practical operation
The size of pressure or the length and internal diameter for changing capillary quartz ampoule 8, are adjusted the flow velocity of liquid in chip 7.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (10)
1. a kind of micro-fluidic fluid drive apparatus characterized by comprising
For storing the caisson of high pressure gas；
The gas outlet seal of pressure regulator valve, the first end of the pressure regulator valve and the caisson is cooperatively connected, the pressure regulator valve
Second end is provided with for the outlet nozzle with pipeline connection.
2. micro-fluidic fluid drive apparatus according to claim 1, which is characterized in that the caisson includes inflatable
Structure.
3. micro-fluidic fluid drive apparatus according to claim 2, which is characterized in that the caisson include cylinder,
Preceding sealing cover and rear sealing cover, the preceding sealing cover and it is described after sealing cover be set in the cylinder and with the cylinder
The gas storage cavity for storing high pressure gas is surrounded, the first end of the pressure regulator valve and the cylinder are engaged by clamping, and the tune
The air inlet of pressure valve is docked with the gas outlet for being formed in the preceding sealing cover, on the rear sealing cover and/or the cylinder
It is formed with the inflating port for inflation.
4. micro-fluidic fluid drive apparatus according to claim 1, which is characterized in that the caisson includes replaceable
Formula gas cylinder, the replaceable gas cylinder are detachably connected with the pressure regulator valve.
5. micro-fluidic fluid drive apparatus according to claim 4, which is characterized in that the caisson further include:
One end is provided with the pressure regulation valve housing, and tank, described tank one end and the pressure regulator valve are formed in the shell
Air inlet connection, the other end is formed with for the opening for the replaceable gas cylinder disengaging；
The end cap being spirally connected with the other end of the shell holds out against the replaceable gas cylinder.
6. a kind of microfluidic system characterized by comprising
Micro-fluidic fluid drive apparatus as described in claim 1-5 any one；
Oil storage bottle, the oil storage bottle are connected to by tracheae with the gas outlet of the pressure regulator valve of the micro-fluidic fluid drive apparatus；
The chip being connected to by delivery pipe with the oil storage bottle, the micro-fluidic fluid drive apparatus pass through tracheae to the oil storage
Bottle input high pressure gas is to drive the oil in the oil storage bottle to flow into the chip through the delivery pipe.
7. microfluidic system according to claim 6, which is characterized in that the delivery pipe detachably connects with the oil storage bottle
It connects, the delivery pipe is fixedly connected with the chip.
8. microfluidic system according to claim 6 or 7, which is characterized in that the delivery pipe includes sample cell, the sample
Quality control includes main paragraph and sample segments, and the both ends of the main paragraph are connect with the oil storage bottle and the chip respectively, institute
Sample segments are stated to be detachably connected with the main paragraph.
9. microfluidic system according to claim 8, which is characterized in that the delivery pipe further includes petroleum pipeline, described defeated
The outlet end of oil pipe and the outlet end of the sample cell are connected in parallel on the arrival end of the chip.
10. according to microfluidic system described in claim 6,7 and 9 any one, which is characterized in that the outlet end of the chip
It is provided with the capillary quartz ampoule being adjusted for the flow velocity to liquid in the chip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811331709.4A CN109441754A (en) | 2018-11-09 | 2018-11-09 | A kind of microfluidic system and its micro-fluidic fluid drive apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811331709.4A CN109441754A (en) | 2018-11-09 | 2018-11-09 | A kind of microfluidic system and its micro-fluidic fluid drive apparatus |
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| Publication Number | Publication Date |
|---|---|
| CN109441754A true CN109441754A (en) | 2019-03-08 |
Family
ID=65551203
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811331709.4A Pending CN109441754A (en) | 2018-11-09 | 2018-11-09 | A kind of microfluidic system and its micro-fluidic fluid drive apparatus |
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Application publication date: 20190308 |