CN109430796A - A kind of preparation method of peppermint Nano capsule - Google Patents
A kind of preparation method of peppermint Nano capsule Download PDFInfo
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- CN109430796A CN109430796A CN201811520467.3A CN201811520467A CN109430796A CN 109430796 A CN109430796 A CN 109430796A CN 201811520467 A CN201811520467 A CN 201811520467A CN 109430796 A CN109430796 A CN 109430796A
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- peppermint
- nano
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- nano capsule
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- 235000016257 Mentha pulegium Nutrition 0.000 title claims abstract description 20
- 244000246386 Mentha pulegium Species 0.000 title claims abstract description 20
- 235000004357 Mentha x piperita Nutrition 0.000 title claims abstract description 20
- 235000001050 hortel pimenta Nutrition 0.000 title claims abstract description 20
- 239000002088 nanocapsule Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 23
- 239000000661 sodium alginate Substances 0.000 claims abstract description 23
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 23
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 15
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 15
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 15
- 239000007908 nanoemulsion Substances 0.000 claims abstract description 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 238000005516 engineering process Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 5
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 4
- 238000000465 moulding Methods 0.000 claims abstract description 3
- 235000019441 ethanol Nutrition 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 7
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 241001474374 Blennius Species 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 239000003595 mist Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 abstract description 4
- 238000001694 spray drying Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 12
- 235000013305 food Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012498 ultrapure water Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910021642 ultra pure water Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001057 ionotropic effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/10—General methods of cooking foods, e.g. by roasting or frying
- A23L5/17—General methods of cooking foods, e.g. by roasting or frying in a gaseous atmosphere with forced air or gas circulation, in vacuum or under pressure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
A kind of preparation method of peppermint Nano capsule, is related to essence Nano capsule.Solution is prepared, prepares sodium alginate soln with water, it is spare；CaCl is prepared with water2Solution, it is spare；Emulsifier is prepared with ethyl alcohol and Tween 80, it is spare；Pre- homogeneous obtains even liquid after Mint Essence and emulsifier homogeneous is added in the sodium alginate soln of preparation；Emulsifying handles obtained even liquid using super-voltage micro jet technology, and CaCl is added2It is reacted, Mint Essence nano-emulsion is made；Obtained Mint Essence nano-emulsion is spray-dried by spray drying, and collection has embedded molding peppermint Nano capsule product and has been sealed.Essence capsule of nano is prepared using super-voltage micro jet technology, obtains that stability is good, good hydrophilic property, the small nano essence microcapsules of partial size.
Description
Technical field
The present invention relates to essence Nano capsules, more particularly, to a kind of peppermint nanometre glue using super-voltage micro jet technology
The preparation method of capsule.
Background technique
Edible essence can assign improvement and optimize the flavor of food as important food additives, but due to essence
Complicated component (alcohol-containing, rouge, ketone etc.), is insoluble in water, and low boiling point is volatile, environmentally sensitive, so that fragrant in food processing process
Essence loss is big or essence is unfavorable for bringing inconvenience to food processing for food processing.It is asked to solve this
Topic, it has been proposed that essence is carried out microencapsulation.
Compared with traditional microcapsules, Nano capsule is advantageous in that: (1) being convenient for the further surface modification of material, mentions
High encapsulation rate changes distribution and targeting；(2) capsule of nano finished product stability is good, easy to process and sterilizing；(3) it receives
Rice glue capsule good biocompatibility, energy degradation in vivo, toxic side effect are small；(4) slow-releasing granules be can be made into, curative effect of medication is extended；(5)
It can prevent the destruction of the other components of food and increase curative effect, and by the attention of people.
Super-voltage micro jet technology is used to prepare ultramicro oil water emulsion, it is different from ultrasonic wave, colloid mill, high shear stirring etc.
The feature of conventional processing method and more super Zhuo Youyi.Process fluid is betted in microfluidizer in super-pressure, and fluid is through micro-
Type channel and enter impact zone in, formed a powerful and uniform reacting field, all fluids all pass through reacting field, and thus produce
Raw cavitation, incident shearing and impact force reduce partial size.
Sodium alginate is the common capsule material of microcapsules technology, and sodium alginate has the advantages that (1) property is steady as capsule material
It is fixed；(2) there is suitable sustained release rate；(3) nontoxic, nonirritant；(4) pharmacological action and the assay of drug are not influenced；(5)
Have certain intensity and plasticity, can be coated with completely core material or drug and additives can compared with fully enter ball skeleton in；
(6) there are the characteristics such as satisfactory viscosity, permeability, hydrophily, dissolubility.When sodium alginate encounters Ca2+Etc. divalent sun from
Son, the Ca under ionotropic change2+By Na+It displaces, forms existing mechanical strength flexible calcium alginate gel again.Seaweed
Not only material is easy to get sour calcium gel, but also has the characteristics that cheap, nonhazardous, mechanical strength are higher.
Summary of the invention
The object of the present invention is to provide a kind of preparation methods of peppermint Nano capsule using super-voltage micro jet technology.
The present invention the following steps are included:
1) solution is prepared, prepares sodium alginate (SA) solution with water, it is spare；CaCl is prepared with water2Solution, it is spare；Use second
Pure and mild Tween 80 prepares emulsifier, spare；
In step 1), it is described when preparing sodium alginate soln with water can small fire interruption heating promote dissolution, then water-bath is cold
But；The mass concentration of the sodium alginate can be 0.6mg/ml, the CaCl2Mass concentration can be 0.67mg/ml；The second
The volume ratio of alcohol and Tween 80 can be 1 ︰ 3.
2) pre- homogeneous, be added in the sodium alginate soln that step 1) is prepared after Mint Essence and emulsifier homogeneous obtain it is even
Liquid；
In step 2), the pre- homogeneous can be used high speed shear homogenizer, and homogeneous revolving speed is 2000r/min, when homogeneous
Between be 5min；The additional amount of the Mint Essence can be the 0.2% of sodium alginate soln by percent by volume；The emulsifier
Additional amount can be the 0.04% of sodium alginate soln by percent by volume.
3) emulsifying, the even liquid that step 2) is obtained are handled using super-voltage micro jet technology, and CaCl is added2Into
Row reaction, is made Mint Essence nano-emulsion；
In step 3), the pressure of the super-voltage micro jet can be 15000Psi, and number of processes is 3 times, the 3rd processing
Even liquid and CaCl afterwards2It reacts and Mint Essence nano-emulsion is made, treatment process meeting heat release uses cooling bath to reduce essence loss
Solution is cooled down.
4) it is spray-dried, the Mint Essence nano-emulsion that step 3) is obtained is spray-dried, and collection has embedded molding peppermint
Nano capsule product is simultaneously sealed.
In step 4), the technological parameter of the spray drying is preferably that inlet air temperature is 160 DEG C, and air inlet flow is
0.5m3/ min, feed rate 400ml/h, atomisation pressure 200kPa.
Compared with prior art, the present invention prepares essence capsule of nano using super-voltage micro jet technology, obtains steady
Qualitative good, good hydrophilic property, the small nano essence microcapsules of partial size.
Detailed description of the invention
Fig. 1 is the scanning electron microscope (SEM) photograph of the embodiment of the present invention.
Specific embodiment
Following embodiment will the present invention is further illustrated in conjunction with attached drawing.
The embodiment of the present invention the specific process steps are as follows:
1) wall material solution is prepared
0.6mg/ml sodium alginate (SA) solution is prepared with ultrapure water；0.06g sodium alginate is weighed in 100ml ultrapure water
In, it is dissolved to sodium alginate.
2) CaCl is prepared2
Weigh 0.335g CaCl2In 50ml ultrapure water dissolve be made stock solution, liquid-transfering gun pipette 2ml stock solution in
0.67mg/ml CaCl is made in 18ml ultrapure water2Use liquid.
3) compound emulsifying agent is prepared to be added in SA solution
0.2ml Mint Essence and ethyl alcohol-Tween 80 composite emulsifier of 1 ︰ 3 of 0.04ml volume ratio are added into SA solution.
4) emulsifying
By obtained solution in high speed shear homogenizer 2000r/min homogeneous 5min.
5) super-voltage micro jet
With super-voltage micro jet processing solution 3 times, and in the 3rd processing solution to 0.67mg/ml CaCl2In solution, shake
Even obtained Mint Essence nano-emulsion.
6) it is spray-dried
Mint Essence nanoemulsions are spray-dried, the peppermint Nano capsule product for having embedded forming is collected and are sealed
Cryo-conservation.
Fig. 1 provides the scanning electron microscope (SEM) photograph of the embodiment of the present invention.
Claims (10)
1. a kind of preparation method of peppermint Nano capsule, it is characterised in that the following steps are included:
1) solution is prepared, prepares sodium alginate soln with water, it is spare；CaCl is prepared with water2Solution, it is spare；With ethyl alcohol and Tween 80
Emulsifier is prepared, it is spare；
2) pre- homogeneous obtains even liquid after Mint Essence and emulsifier homogeneous is added in the sodium alginate soln that step 1) is prepared；
3) emulsifying, the even liquid that step 2) is obtained are handled using super-voltage micro jet technology, and CaCl is added2It carries out anti-
It answers, Mint Essence nano-emulsion is made；
4) it is spray-dried, the Mint Essence nano-emulsion that step 3) is obtained is spray-dried, and collection has embedded molding peppermint nanometer
Capsule product is simultaneously sealed.
2. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that described to use water in step 1)
The heating of small fire interruption promotes dissolution, then water-bath cooling when preparing sodium alginate soln.
3. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 1), the seaweed
The mass concentration of sour sodium is 0.6mg/ml.
4. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 1), the CaCl2
Mass concentration be 0.67mg/ml.
5. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 1), the ethyl alcohol
Volume ratio with Tween 80 is 1 ︰ 3.
6. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that described pre- equal in step 2)
Matter uses high speed shear homogenizer, and homogeneous revolving speed is 2000r/min, homogenizing time 5min.
7. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 2), the peppermint
The additional amount of essence is by 0.2% that percent by volume is sodium alginate soln.
8. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 2), the emulsification
The additional amount of agent is by 0.04% that percent by volume is sodium alginate soln.
9. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 3), the superelevation
The pressure for pressing microjet is 15000Psi, and number of processes is 3 times, even liquid and CaCl after the 3rd processing2It reacts and Mint Essence is made
Nano-emulsion, treatment process meeting heat release, cools down solution using cooling bath.
10. a kind of preparation method of peppermint Nano capsule as described in claim 1, it is characterised in that in step 4), the spray
It is 160 DEG C that the dry technological parameter of mist, which is inlet air temperature, and air inlet flow is 0.5m3/ min, feed rate 400ml/h, it is spraying
Pressure is 200kPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811520467.3A CN109430796A (en) | 2018-12-12 | 2018-12-12 | A kind of preparation method of peppermint Nano capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811520467.3A CN109430796A (en) | 2018-12-12 | 2018-12-12 | A kind of preparation method of peppermint Nano capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109430796A true CN109430796A (en) | 2019-03-08 |
Family
ID=65557513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811520467.3A Pending CN109430796A (en) | 2018-12-12 | 2018-12-12 | A kind of preparation method of peppermint Nano capsule |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102653704A (en) * | 2011-03-04 | 2012-09-05 | 上海爱普植物科技有限公司 | Preparation method of small peppermint essence soft capsule taking calcium alginate as wall material |
| CN103320223A (en) * | 2013-06-03 | 2013-09-25 | 吴江市利达上光制品有限公司 | Preparation method for nano mint essence |
| CN104207076A (en) * | 2014-09-17 | 2014-12-17 | 天津春发生物科技集团有限公司 | Method for preparing essential oil microcapsules |
| CN104263513A (en) * | 2014-09-17 | 2015-01-07 | 天津春发生物科技集团有限公司 | Essence micro-capsule wall material and essence micro-capsule |
-
2018
- 2018-12-12 CN CN201811520467.3A patent/CN109430796A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102653704A (en) * | 2011-03-04 | 2012-09-05 | 上海爱普植物科技有限公司 | Preparation method of small peppermint essence soft capsule taking calcium alginate as wall material |
| CN103320223A (en) * | 2013-06-03 | 2013-09-25 | 吴江市利达上光制品有限公司 | Preparation method for nano mint essence |
| CN104207076A (en) * | 2014-09-17 | 2014-12-17 | 天津春发生物科技集团有限公司 | Method for preparing essential oil microcapsules |
| CN104263513A (en) * | 2014-09-17 | 2015-01-07 | 天津春发生物科技集团有限公司 | Essence micro-capsule wall material and essence micro-capsule |
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Application publication date: 20190308 |
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