CN109425737A - Biosample check device - Google Patents
Biosample check device Download PDFInfo
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- CN109425737A CN109425737A CN201810969888.8A CN201810969888A CN109425737A CN 109425737 A CN109425737 A CN 109425737A CN 201810969888 A CN201810969888 A CN 201810969888A CN 109425737 A CN109425737 A CN 109425737A
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- box
- cassette loading
- loading section
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- biosample
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- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims description 10
- 238000012360 testing method Methods 0.000 abstract description 41
- 230000001900 immune effect Effects 0.000 abstract description 36
- 239000012491 analyte Substances 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 238000003825 pressing Methods 0.000 description 8
- 206010022000 influenza Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000007689 inspection Methods 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000007373 indentation Methods 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 241000486679 Antitype Species 0.000 description 3
- 206010070834 Sensitisation Diseases 0.000 description 3
- 230000002730 additional effect Effects 0.000 description 3
- 230000002238 attenuated effect Effects 0.000 description 3
- 238000005213 imbibition Methods 0.000 description 3
- 230000008313 sensitization Effects 0.000 description 3
- 230000001235 sensitizing effect Effects 0.000 description 3
- 241000712461 unidentified influenza virus Species 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 238000010009 beating Methods 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A kind of load the issue of the present invention is to provide vibration for being applied to box in carrying case or in carrying case is less and can be improved the Biosample check device of the positioning accuracy of box.Immunologic test device (10) of the invention has cassette loading section (18), detachably loads the box with the carrier for reacting subject with reagent.Cassette loading section (18) allows movement and keeping box (15) in the prescribed limit of the horizontal direction of the box (15) in cassette loading section (18).Moreover, having positioning region (48B, 49B), cassette loading section (18) is not interfered in the accommodated position of cassette loading section (18) and is directly engaged with box (15) to position to box (15).
Description
Technical field
The present invention relates to a kind of Biosample check devices.
Background technique
In recent years, immunologic test device is widely used at medical scene.Immunologic test device is to check from human or animal
Deng one kind of the Biosample check device of Biosample acquired in biology.Immunologic test device can it is easy and promptly into
Row checks the positive and qualitative reaction inspection of feminine gender of the infectious disease of influenza etc etc..In immunologic test device, holding is used
There is the carrier of the reagent to develop the color in conjunction with analyte.In the case where the qualitative reaction inspection for infectious disease, analyte
For antigen, reagent is antibody.Carrier is for example made of nitrocellulose membrane, in general, in the form of the box for being contained in private casing
It is supplied to the users such as medical worker.There is for determining whether the subject there are analyte point sticky on carrier, such as pharynx is wiped
Liquid, nose wipe the body fluid such as liquid and are mixed in liquid obtained by defined solution.
When carrying out immunologic test, firstly, to the carrier point sticky subject in box.Carrying case is equipped in immunologic test device
Load port, point is stained with the box of subject and is loaded into apparatus main body by load port.After box is loaded, opened if instruction checks
Begin, then immunologic test device on carrier with the part reacted with reagent of image-forming component shooting subject, and according to thus obtaining
Image pickup signal measurement reagent color status (concentration, coloration).Also, determine to whether there is in subject according to measurement result
Analyte, and determined that result is prompted to user.
In the immunologic test device documented by patent document 1, it is equipped with the load port of box in apparatus main body, is set in load port
There is the cassette loading section of carrying case.Cassette loading section has the bearing member of the mounting surface with mounting box.Cassette loading section is in accommodated position
It is moved freely in the horizontal direction between pull-out location.Accommodated position be be mounted with the state of box be pressed into from load port and with
Box is contained in the position of the inside of apparatus main body together.Pull-out location is that can load and unload box relative to cassette loading section and pass through loading
Opening's edge horizontal direction is pulled it to the position of the outside of apparatus main body.
Patent document 1: No. 5606285 bulletins of Japan Patent
As described above, the reagent for the carrier that immunologic test device optical detecting is held in advance in box is sticked at time point is checked
Reactiveness between the subject of carrier, therefore box is located in defined reading position inside apparatus main body.This be because
If can not be suitably measured not to be properly located in reading position.
Thus, for example be equipped with the fitting that abuts with box loading body interior, box be pressed into together with cassette loading section in
The inboard of load port.If box is pressed into until abutting with fitting, position becomes defined reading position, thus box
It is located in reading position.
However, in the side so positioned by the fitting for pressing on cassette loading section inside apparatus main body to box
In method, there are the following problems.That is, cassette loading section is pressed on fitting come in the method that positions, user needs to box
Loading part applies strength, therefore load when carrying case is larger.If load when carrying case is larger, be easy to box be applied to compared with
Big vibration.
In the case where subject is the liquid as body fluid, if vibration is larger, at the time of before inspection starts just
It is mobile in the inside of carrier to will lead to subject, therefore it is also possible to influences measurement result.
Also, in the case where being applied with impact to immunologic test device, only by the way that cassette loading section is pressed on fitting
To be positioned, it is also possible to can make cassette loading section mobile because of the impact and generate deviation, so that positioning accuracy reduces.
Summary of the invention
The purpose of the present invention is to provide one kind in carrying case, is applied to vibrating less and can be improved determining for box for box
The Biosample check device of position precision.
In order to solve the above problems, immunologic test device of the invention has: cassette loading section, and detachably loading has
The box for the carrier for reacting subject with reagent, and allow box in cassette loading section horizontal direction prescribed limit in movement
And keeping box；Mobile mechanism, cassette loading section be pressed into and be contained in the accommodated position of the inside of apparatus main body with can be opposite
Make box between the pull-out location that cassette loading section loads and unloads the outside that box and cassette loading section are drawn out to apparatus main body in the horizontal direction
Loading part is mobile；And positioning region, cassette loading section is not interfered in accommodated position and is directly engaged with box to position to box.
It is preferred that cassette loading section has the bearing member of mounting box and is set to bearing member and abuts with the box on bearing member, and limit
The limiting unit of the movement beyond prescribed limit in the horizontal direction of box on bearing member processed, and by between limiting unit and box
The movement in the prescribed limit of the horizontal direction of the box in cassette loading section is allowed in the gap ensured.
Preferred orientation portion has respectively and two sides orthogonal with the moving direction of cassette loading section, the width direction of box
A pair of of holding section of engaging.
It is preferred that holding section is convex, and the quilt of the spill engaged with holding section is equipped in two sides of the width direction of box
Holding section.
It is preferably provided with lid, which is to be equipped with the closed position of the load port of cassette loading section in covering and open beating for load port
The cover being opened and closed between open position, and it is mobile to closed position from open position when abutted with cassette loading section and from pull-out position
It sets towards accommodated position and is pressed into cassette loading section.
It is preferably provided with the force section to exert a force to cassette loading section towards pull-out location.
It is preferably provided with the damper of the active force of decaying force section.
Invention effect
According to the present invention, in carrying case, it is applied to the vibration positioning accuracy that is less and can be improved box of box.
Detailed description of the invention
Fig. 1 is the perspective view for indicating the appearance of immunologic test device.
Fig. 2 is the perspective view for indicating to cover the appearance of immunologic test device in the open state.
Fig. 3 is the cross-sectional view for indicating a part of inside of immunologic test device.
Fig. 4 is the top view for indicating the internal structure of box.
Fig. 5 is the perspective view for indicating the structure of loader mechanism of box.
Fig. 6 is the perspective view for indicating to cover the structure of the loader mechanism of box in the open state.
Fig. 7 is the top view for indicating the modular construction of loader mechanism of box.
Fig. 8 is the top view of the state of unloaded box and the loader mechanism positioned at the box of the state of pull-out location.
Fig. 9 is the explanatory diagram in the gap of cassette loading section.
Figure 10 is the top view of the loader mechanism of the box for the state for being mounted with the state of box and being located at pull-out location.
Figure 11 is the top view of the loader mechanism of the box for the state for being mounted with the state of box and being located at accommodated position.
Figure 12 is the explanatory diagram of the engaged part of box.
Figure 13 is the explanatory diagram for indicating the state to the mobile cassette loading section on the way of accommodated position.
Figure 14 is the explanatory diagram for indicating the state of the cassette loading section in front of accommodated position.
Figure 15 is the explanatory diagram for indicating the state of the cassette loading section on accommodated position.
Specific embodiment
In fig. 1 and fig. 2, the medical treatment organ such as being set to hospital of immunologic test device 10.Immunologic test device 10 has
There is apparatus main body 10A.In immunologic test device 10, the special box that point sticky there are the subjects such as body fluid is accommodated in apparatus main body 10A
15, and immunologic test is carried out to subject.Box 15 is the box with the carrier 30 as one kind (with reference to Fig. 3) for making reagent and tested precursor reactant.
Subject be, for example, will wipe liquid from the pharynx acquired in patient, nose wipe the body fluid such as liquid be mixed in as defined in extracting solution obtained by it is molten
Liquid.
The lid 17 that can be opened and closed and loading of opening 16, covering opening 16 are equipped in the front surface lower part of apparatus main body 10A
The cassette loading section 18 of the hypocrateriform of box 15.Opening 16 plays work as the load port for box 15 to be loaded into cassette loading section 18
With.
The box 15 with the carrier for reacting subject with reagent is detachably loaded in cassette loading section 18.Cassette loading section
18 have the bearing member 18A of the mounting surface with carrying case 15, and as be described hereinafter, the level side of box 15 are allowed on bearing member 18A
To prescribed limit in movement and keeping box 15.
Also, cassette loading section 18 the accommodated position that is pressed into and is contained in the inside of apparatus main body 10A with as shown in Fig. 2,
Box 15 can be loaded and unloaded relative to cassette loading section 18 and cassette loading section 18 is drawn out in the horizontal direction (being X-direction in Fig. 1 and Fig. 2)
It is moved between the pull-out location of the outside of apparatus main body 10A.The sliding and the opening and closing of lid 17 link, if lid 17 is opened,
It is moved to pull-out location from accommodated position, when lid 17 is closed, lid 17 is abutted with cassette loading section 18, and cassette loading section 18 is pressed into
Accommodated position in the inside of apparatus main body 10A.
The front surface top of apparatus main body 10A is inclined surface, is equipped with touch panel 19 in the inclined surface.Touch panel 19
Middle operation instruction of the input from users such as medical workers, and show information related with immunologic test.There is inspection in operation instruction
Look into start instruction, terminate instruction, there are the printout of the measurement result of analyte etc instructions etc. in subject.With exempt from
Epidemic disease checks patient ID (the identification data for having the patient for acquiring subject for identification in related information
(Identification Data)), self-check start pass through time, measurement result etc..
Box 15 has the shell 15A of inner containment carrier 30 as one kind (referring to Fig. 3) etc..Point sticky is equipped in the upper surface of shell 15A
The point sticky mouth 20 of the inverted cone-shaped of subject.Also, the label for recording patient ID etc. is pasted in the upper surface of shell 15A
21。
As shown in Figures 3 and 4, band-like carrier 30 as one kind is accommodated along its length in the shell 15A of box 15.Carrier 30 as one kind example
It is such as made of nitrocellulose membrane, and there is the test zone 31 being made of two p-wires A, B and control line C.On p-wire A
It is fixed with the 1st reagent to develop the color in conjunction with the 1st analyte.It is fixed in conjunction with the 2nd analyte and develops the color on p-wire B
The 2nd reagent.Control line C be determine whether the subject for being appropriate for the amount of measurement flows normally through the line of carrier 30 as one kind, and
It is appropriate for colour developing when the subject of amount of measurement flows normally through carrier 30 as one kind.
For example, the 1st analyte is influenza A, the 2nd analyte is Type B influenza virus.Also, the 1st reagent by
Anti-influenza type A virus antibody, anti-influenza type A virus antibody combination gold colloid, anti-influenza type A virus antibody combine coloring latex etc.
It constitutes.Also, the 2nd reagent is by anti-Type B Antibody of Influenza, anti-Type B Antibody of Influenza combination gold colloid, anti-Type B influenza disease
Malicious antibody combines coloring latex etc. to constitute.In this way, the 1st reagent, the 2nd reagent include the antibody of influenza virus.
The observation of the color status for observing these p-wires A, B and control line C is formed in the lower surface of shell 15A
Window 32.In cassette loading section 18 and maintaining part 45, opening is also respectively formed in position corresponding with the observation window 32 of shell 15A
33 and opening 34.
In shell 15A, other than carrier 30 as one kind, infusion pad 35, imbibition pad 36, reduction flow container 37 and sensitization are also accommodated
Flow container 38.They are the structure for carrying out sensitized treatment.Sensitized treatment be the developing concentration of the 1st reagent or the 2nd reagent compared with
In the case where low, so that reducing solution and sensitizing solution is flowed through p-wire to improve the processing of developing concentration, and without sensitized treatment and
According to being measured as a result, progress as needed.Restoring flow container 37 and sensitization flow container 38 is to store this reducing solution and sensitizing solution
Storage unit.
The medical fluid extension with crushing reduction flow container 37 and the press section for being sensitized flow container 38 is equipped in apparatus main body 10A
(not shown).If reduction flow container 37 is pressed mechanism crushing, reducing solution is transported to test zone 31 by pad 35 of being infused, and
It is absorbed by imbibition pad 36.If sensitization flow container 38 is crushed, sensitizing solution is transported to test zone 31.
In Fig. 2, maintaining part 45 and determination part 43 are equipped in apparatus main body 10A.Maintaining part 45 is in pull-out location and holds
It receives and movably keeps cassette loading section 18 between position.
In the case where box 15 is located at accommodated position, determination part 43 is configured at and the observation window 32 of shell 15A and box-packed load
The opposed position of the opening 33 in portion 18.Determination part 43 is from passing through observation window 32 and opening 33 to by p-wire A, B and control line C structure
At 31 irradiation light of test zone a pair of of light source 50 and shoot test zone 31 image-forming component 51 constitute.
Light source 50 is, for example, the module for being built-in with LED (light emitting diode (Light Emitting Diode)), and is issued
White light.In addition, as long as the coloration before and after sensitized treatment can be distinguished, or being issued monochromatic about light source 50
Light source.Also, light source 50 can also be by monochromatic multiple module compositions of sending different wave length.Image-forming component 51 is, for example, more
A photodiode exports and photodiode with the line sensor of the linear alignment or with the area sensor of rectangular arrangement
The corresponding image pickup signal of reception light quantity.
Also, medical fluid extension (not shown) is by pressing reduction flow container 37 and is sensitized the press section of flow container 38 and this is driven to press
Motor of splenium etc. is constituted.
In Fig. 5 into Fig. 7, the loader mechanism for being set to box 15 in apparatus main body 10A is shown.Loader mechanism includes protecting
Hold the positioning mechanism of the holding mechanism of cassette loading section 18, mobile mechanism and box 15.Loader mechanism has base portion 55, maintaining part
45, cassette loading section 18, guide shaft 46, helical spring 47 and a pair of of side cover 48,49.Hereinafter, for convenience of explanation, indicating device master
When the direction of body 10A, X-direction is known as front-rear direction, in X-direction, the side for being equipped with lid 17 is known as front, it will be opposite
Side is known as rear.Also, the Y-direction orthogonal with X-direction is known as width direction.
Base portion 55 is configured at the inboard of opening 16, and is set to apparatus main body 10A.Maintaining part is installed in base portion 55
45.Also, movably keep box-packed between the accommodated position shown in Fig. 5 of maintaining part 45 and pull-out location shown in fig. 6
Load portion 18.
As shown in fig. 7, being formed with a pair of guide rails 45A in the two sides of opening 34 in maintaining part 45.Guide rail 45A be formed in
The engaging (not shown) of the protrusion of the lower surface of maintaining part 45 and the moving direction for guiding maintaining part 45.Also, it is set in maintaining part 45
There is the bearing portion 45B for movably keeping guide shaft 46.Guide shaft 46 is, for example, that section is circular cylindrical shape.Bearing portion 45B
In be formed with being inserted through hole 45C with guide shaft 46 internal diameter that roughly same outer diameter.
For guide shaft 46 being inserted through in the state of being inserted through hole 45C, cassette loading section 18 is fixed in one end.In the other end of guide shaft 46
Anti-delinking part 46A equipped with flange shape.Anti-delinking part 46A engages with bearing portion 45B, and guide shaft 46 is prevented to be detached from from bearing portion 45B.
Also, helical spring 47 is installed in the periphery of guide shaft 46.One end of helical spring 47 is abutted with cassette loading section 18,
The other end is abutted with bearing portion 45B.Helical spring 47 is to generate relative to maintaining part 45 to cassette loading section 18 towards pull-out location
The force section of the active force of force.By helical spring 47, cassette loading section 18 is towards pull-out location stress, and the anticreep of guide shaft 46
Portion 46A then prevents cassette loading section 18 to be detached from from maintaining part 45.
Also, in maintaining part 45, in the length parallel with moving direction (X-direction) of cassette loading section 18 installed
The two sides of the orthogonal width direction in direction (Y-direction) are equipped with mounting portion 45D, 45E for installing side cover 48,49.
As can be seen from figures 8 and 9, cassette loading section 18 has the bearing member 18A of mounting box 15, is set to the outer of bearing member 18A
The framework 18B in week, the horizontal direction for being abutted with the lateral surface of the box 15 on bearing member 18A and limiting the box 15 on bearing member 18A
On the movement beyond prescribed limit limiting unit 18C.Bearing member 18A has with the flat of a circle bigger than the planar dimension of box 15
Face size and load box 15, parallel with X-Y plane mounting surface.Opening is formed in the center of the mounting surface of bearing member 18A
33。
Framework 18B is formed in the periphery of bearing member 18A, and forms the wall erected from bearing member 18A to Z-direction, and surround
The lateral surface of box 15 on bearing member 18A.By framework 18B, box 15 is prevented to be detached from from bearing member 18A.Also, pass through setting
Framework 18B can show the " loaded " position of box 15 to user.
Limiting unit 18C is the front end and rear end for being located at box 15 with the lateral surface of box 15, flat with width direction (Y-direction)
Capable each side 15B and positioned at box 15 width direction (Y-direction) two sides, each side 15C of (X-direction) along its length
Opposed position is respectively equipped with each two respectively, adds up to 8.Limiting unit 18C and the lateral surface of the box 15 in cassette loading section 18 support
Connect the movement beyond prescribed limit in simultaneously limit levels direction (X-Y plane).On the other hand, as shown in figure 9, in limiting unit 18C
Ensure to have clearance G between each side 15B, 15C of box 15.Cassette loading section 18 passes through the clearance G so ensured, allows box-packed load
Movement in the prescribed limit of the horizontal direction of box 15 in portion 18.
Also, in cassette loading section 18, the sleeve 18D of one end of fixed guide shaft 46 is equipped in the rear end of bearing member 18A.Sleeve
One end of helical spring 47 is installed, one end of helical spring 47 is abutted with the rear end of bearing member 18A in 18D.
Also, in cassette loading section 18, rack gear 18E is equipped in the left side configured with side cover 48.Rack gear 18E and pinion gear 53
Engaging.Pinion gear 53 is rotatably freely installed on side cover 48.Rotation relative to pinion gear 53 is installed in pinion gear 53, is generated
The load mechanism 54 of load as becoming resistance.
If cassette loading section 18 is mobile, rack gear 18E engages with pinion gear 53, so that pinion gear 53 rotates.Load mechanism 54
Relative to the rotation of pinion gear 53, the load for becoming resistance is generated.Therefore, the effect that helical spring 47 applies cassette loading section 18
Power is attenuated.That is, rack gear 18E, pinion gear 53 and load mechanism 54 as decaying helical spring 47 active force damper and
It plays a role.By the effect of this damper, prevent cassette loading section 18 from moving suddenly by the active force of helical spring 47,
Also, inhibit the vibration of helical spring 47, therefore cassette loading section 18 can be moved steadily.
Also, as shown in fig. 6, being equipped with the roller portion 17B with the inner surface for being set to lid 17 in the front end of cassette loading section 18
It abuts to bear the pressed portion 18F of the pressing from roller portion 17B.Lid 17 is equipped with hinge 17A in lower end side, and via hinge
17A is rotatably set to apparatus main body 10A.
If rotating lid 17 from open position shown in fig. 6 towards closed position shown in fig. 5, roller portion 17B presses quilt
Press section 18F, so that cassette loading section 18 is pressed into towards accommodated position.Cassette loading section 18 passes through helical spring 47 towards pull-out position
Stress is set, therefore when making lid 17 turn to closed position, the force of helical spring 47 is resisted on one side, on one side towards closed position
Rotation.
Be equipped in apparatus main body 10A be located at closed position lid 17 is engaging, locking mechanism (not shown).If 17 turns of lid
It moves to closed position, then locking mechanism engages with lid 17 and limit the rotation to open position, so that lid 17 is held in closing
Position.Cassette loading section 18 passes through helical spring 47 towards pull-out location stress.Therefore, during lid 17 is located at closed position, lid
In 17, roller portion 17B still bears to press from the pressed portion 18F of cassette loading section 18.But by the effect of locking mechanism,
Lid 17 will not be opened because of the active force of helical spring 47.Also, during lid 17 is held in closed position, cassette loading section 18
It is held in accommodated position.
On the other hand, for example, if slightly positioned at the lid 17 of closed position, locking mechanism is released from for indentation.If the machine of locking
Structure is released from, then lid 17 bears the pressing from cassette loading section 18 by the active force of helical spring 47 on one side, on one side to beating
Open position rotation.When lid 17 is rotated to open position, above-mentioned damper plays a role and lid 17 is slowly opened.
As shown in fig. 7, side cover 48,49 is respectively arranged in mounting portion 45D, 45E of maintaining part 45, and such as Fig. 5, Figure 10 and figure
Shown in 11, it is configured at the two sides of the width direction (Y-direction) of the cassette loading section 18 positioned at accommodated position.As shown in fig. 7, each
In side cover 48,49, it is equipped in the top for being located at the box 15 of accommodated position prominent from the two sides of the width direction of box 15 towards center
And cover cover portion 48A, 49A of a part of the upper surface of box 15.
Also, positioning region 48B, the 49B rearward extended in X direction is equipped in side cover 48,49.Positioning region 48B, 49B
It closes, and carries out including the x-direction and y-direction of box 15 with each side cal15 of the width direction of box 15 (Y-direction) respectively
The positioning of horizontal direction.In positioning region, the rear end of 48B, 49B are equipped with holding section 48C, 49C.As shown in Figures 10 and 11, each engaging
Portion 48C, 49C are each side 15C convex outstanding towards box 15, and the cross sectional shape in X-Y plane is in substantially semi-circular.
Box 15 width direction (Y-direction) each side 15C be equipped with engage respectively with each holding section 48C, 49C by card
Conjunction portion 15D.It other than Figure 10 and Figure 11, as shown in figure 12, is bounded on each side in the 15C of face, engaged part 15D is towards width direction
Concavity spill, each holding section 48C, 49C of convex are embedded in the engaged part 15D of the spill.Each holding section 48C,
49C be equivalent to respectively and orthogonal with moving direction (X-direction) of cassette loading section 18, box 15 width direction (Y-direction) two
A pair of of holding section that a side cal15 closes.
As shown in figure 5, the position of the Z-direction of positioning region 48B, 49B is configured at position more higher than the upper end of cassette loading section 18
It sets, therefore will not be abutted completely with to the mobile cassette loading section 18 of X-direction.Therefore, each holding section 48C, 49C do not interfere box-packed load
Portion 18 and directly engage with the engaged part 15D of each side 15C of box 15 to carry out the horizontal direction of box 15 (in X-Y plane)
Positioning.
Hereinafter, also referring to Figure 13 to Figure 15 to be illustrated to the effect based on above structure.Firstly, using immunologic test
Device 10 carries out the users such as the medical worker of immunologic test and the subject point of subject is sticked at load by the point sticky mouth 20 of box 15
Body 30.The box 15 that point sticky terminates is loaded into immunologic test device 10 by user.
In carrying case 15, as shown in Figures 2 and 6, user is first turned on the lid 17 of immunologic test device 10.Cassette loading section
18 pass through helical spring 47 to pull-out location stress.In the state that lid 17 is located at closed position, pass through 47 direction of helical spring
The cassette loading section 18 of pull-out location stress is held in accommodated position.If lid 17 is opened, the opening to open position with lid 17
It is mobile towards pull-out location by the cassette loading section 18 of 47 stress of helical spring in linkage.
Also, pass through relative to the active force of the helical spring of the cassette loading section 18 47 by rack gear 18E, pinion gear 53 and negative
The damper that lotus mechanism 54 is constituted is attenuated.Therefore, cassette loading section 18 will not fly out towards pull-out location suddenly.
As shown in Figures 2 and 6, in the state that lid 17 is opened and cassette loading section 18 is located at pull-out location, user is by box 15
It is placed on the bearing member 18A of cassette loading section 18.Each side 15B, 15C of box 15 are abutted with limiting unit 18C, thus cassette loading section
The movement beyond prescribed limit in horizontal direction in 18 is limited.Moreover, the surrounding of box 15 is surrounded by framework 18B, because
This can prevent the disengaging from cassette loading section 18.
Also, as shown in figure 9, in cassette loading section 18, between limiting unit 18C and box 15 respective lateral surface 15B, 15C
Ensure there is clearance G.Therefore, in cassette loading section 18, allow the movement of the horizontal direction in the prescribed limit of box 15.Also, by
In there are clearance Gs, therefore the case where compared to gapless G, load when box 15 to be placed in bearing member 18A is few.This is because
If gapless G, resistance can be generated due to the frictional force of limiting unit 18C and the side of box 15, but clearance G if it exists, then will not
Generate this resistance.
It is mounted in after cassette loading section 18 in box 15, lid 17 is closed.As shown in Figures 5 and 6, if lid 17 is towards closed position
Rotation, then the roller portion 17B of lid 17 presses the pressed portion 18F of cassette loading section 18.Box by the pressing, positioned at pull-out location
Loading part 18 is pressed into towards accommodated position.
As shown in figure 13, cassette loading section 18 is guided by guide shaft 46 with the engaging of bearing portion 45B, and court in X direction
It is pressed into accommodated position.In the indentation, helical spring 47 compresses.Also, pass through side cover 48,49, the width direction of box 15
Two sides are capped, therefore are reliably prevented box 15 and are detached to the width direction of cassette loading section 18.If cassette loading section 18 is towards receiving
Position is pressed into, then each holding section 48C, the 49C of box 15 close to positioning region 48B, 49B.
As shown in figure 14, if lid 17 is further rotated towards closed position, cassette loading section 18 is further pressed into, thus
Each holding section 48C, 49C of positioning region 48B, 49B are abutted with the rear end of box 15.The side of positioning region 48B, 49B to extend outward
Formula flexible deformation and each holding section 48C, 49C climb onto each side 15C of box 15.
As shown in figure 15, further, if lid 17 reaches closed position, cassette loading section 18 is pressed into accommodated position, lid 17
By locking mechanism (not shown), resists the force of helical spring 47 and be held in closed position.Lid 17 is held in closed position,
Thus cassette loading section 18 is also held in accommodated position.
In the accommodated position, each holding section 48C, 49C engage with each engaged part 15D of box 15.In cassette loading section 18,
Ensure there is clearance G between box 15 and limiting unit 18C.By clearance G, in cassette loading section 18, the horizontal direction of box 15 is allowed
Prescribed limit in movement.Also, positioning region 48B, 49B and cassette loading section 18 do not interfere, and positioning region 48B, 49B and box 15
Directly engage.
Cassette loading section 18 is held in accommodated position by lid 17.Therefore, engaged by box 15 with each of positioning region 48B, 49B
The engaging of portion 48C, 49C, in cassette loading section 18, box 15 moves within the specified scope and the position of the horizontal direction of box 15 is determined
Position.
In this way, cassette loading section 18 allows the shifting in the prescribed limit of the horizontal direction of box 15 in immunologic test device 10
Dynamic and keeping box 15.Also, in the accommodated position of cassette loading section 18, positioning region 48B, 49B do not interfere cassette loading section 18 and and box
15 directly engagings are to position box 15.As a result, in carrying case 15, the vibration for being applied to box 15 is less and can be improved box
Positioning accuracy.
That is, in this example, be located through positioning region 48B, 49B of box 15 directly engage with box 15 to carry out, there is no need to
Cassette loading section 18 is pressed on into fitting as in the past.Therefore, the impact for being applied to cassette loading section 18 is less, and is applied to box
15 vibration is also less.Also, even if vibration is applied to cassette loading section 18 when mobile to the accommodated position of cassette loading section 18, by
Movement in the prescribed limit for allowing box 15 in cassette loading section 18, therefore the vibration for being transmitted to box 15 can also be inhibited.
Also, the movement in the prescribed limit due to allowing box 15 in cassette loading section 18, positioning region 48B, 49B with
Impact when box 15 abuts can also be mitigated.The vibration for being applied to box 15 as a result, can also be inhibited.
In this way, being applied to the vibration of box 15 is inhibited, therefore even if subject is as body fluid the case where liquid
Under, carrying out mobile situation also in the inside subject of carrier can be inhibited, so that a possibility that influencing measurement result also drops
It is low.In this way, the present invention is particularly effective when subject is liquid.
Also, among existing immunologic test device, also have without using cassette loading section 18 and by box 15 be directly loaded up in
The device of load port.In this device, the inboard slot for the load port for being configured at box is correspondingly formed with the size of box,
Thus the positioning of the width direction of box is carried out.In this case, in order to be accurately proceed the positioning of box, the width of slot can only be made
Degree narrows, so that load when resistance when being pressed into box is larger and carrying case is larger.If load when carrying case is larger, not only
It is difficult to be inserted into box, but also excessive power can be applied to box, therefore is easy to be applied to biggish vibration to box.
Different from this prior art, the immunologic test device 10 of this example is not necessarily to and box 15 for the positioning of width direction
Size correspondingly narrowly formed carrying case 15 slot.Therefore, load when carrying case 15 is also less, therefore can press down
System is applied to the vibration of box 15.
Also, positioning region 48B, 49B are used as in this example, thus box 15 is suitably accurately positioned.Positioning region
48B, 49B engage with box 15, therefore compared to the method that cassette loading section 18 or box 15 are only pressed on fitting etc, even if right
A possibility that apparatus main body 10A applies impact, and box 15 moves and generates deviation is also less.
About box 15, by the reactiveness of the subject on 43 optical detecting carrier 30 as one kind of determination part, therefore can high-precision
A possibility that ground is positioned and generates deviation reduction, thus measurement accuracy is improved.As described above, according to the present invention,
When carrying case 15, it is applied to the vibration positioning accuracy that is less and can be improved box 15 of box 15.
Also, as in this example, if without box 15 to the pressing of fitting or carrying case 15 when load it is less, even if
More immunologic test devices 10 not interval and in the case where be arranged, can also expect swimmingly carry out box 15
Loading additional effect.The additional effect is as follows.
That is, load when if desired box 15 is to the pressing of fitting or carrying case 15 is larger, then need tightly to be grabbed with hand-tight
The firmly two sides of the width direction of box 15, and by the indentation of box 15 in the inboard operation of apparatus main body 10A.If box to be firmly grasped by
15, then compared to slight the case where clamping, catch the hand of box 15 that can expand along the width direction of apparatus main body 10A.If device master
The narrower width of body 10A then catches the hand of box 15 can be prominent from the width of apparatus main body 10A, and hand can touch adjacent match sometimes
Other devices for setting and can not accurately be pressed into box 15.
At medical scene, in order to the multiple inspections of parallel processing simultaneously, more immunologic test devices of transversely arranged configuration
10 go forward side by side enforcement with the case where it is also more.Moreover, can only ensure installation space of the relatively narrow space as immunologic test device 10
The case where it is also more, in this case, more immunologic test devices 10 not interval and the case where being arranged it is also more.?
In this case, a possibility that catching the hand of box 15 to interfere adjacent other devices is higher, therefore can not swimmingly carrying case 15.
In contrast, as long as the immunologic test device 10 of this example resists the force of helical spring 47 and by box 15 and box-packed load
Portion 18 is pressed into accommodated position and is just able to carry out loading.Box 15 is located through positioning region 48B, 49B to carry out, therefore in indentation box
When 15, without being firmly grasped by box 15 with hand and the operation being pressed into that takes efforts, helical spring 47 can be resisted by only applying
Force degree power.Therefore, though more immunologic test devices 10 not interval and the case where be arranged
Under, it can also expect the additional effect that can swimmingly carry out the loading of box 15.
Also, load when such carrying case 15 is smaller, therefore as in this example, additionally it is possible to make cassette loading section 18 to receiving
The indentation of position and the opening and closing of lid 17 link.
Also, each holding section 48C, 49C of positioning region 48B, 49B are to close with each side cal15 of the width direction of box 15
A pair of of holding section, therefore for example compared to pressing box 15 rear end face fitting, impact it is less.
Moreover, a pair of holding section 48C, 49C and two sides for being respectively formed in the moving direction (X-direction) along box 15
The engaged part 15D of 15B engages, to carry out the positioning of moving direction (X-direction).Also, a pair of holding section 48C, 49C is from two
Side clamps two side 15B of box 15, thus carries out the positioning of the width direction (Y-direction) of box 15.In this way, a pair of of holding section
48C, 49C are able to carry out the moving direction (X-direction) and the width direction orthogonal with moving direction (X-direction) (Y-direction) of box 15
The positioning in the two directions, therefore compared to being positioned by width direction and moving direction of the different components to box 15
Situation can simplify structure.
Also, the opening and closing of lid 17 and the pull-out location of cassette loading section 18 and the mobile linkage of accommodated position, therefore operability
Well.
Also, has the damper being made of rack gear 18E, pinion gear 53 and load mechanism 54, therefore to cassette loading section 18
The active force of the helical spring 47 to exert a force to pull-out location is attenuated.Therefore, when opening lid 17, cassette loading section 18 will not be suddenly
It flies out.
In this example, the opening and closing of lid 17 and the movement of cassette loading section 18 are linked, but without centainly linking.
In the case where not linking with lid 17, need for locking mechanism to be set to maintaining part 45 etc. to replace being set to lid 17, the locking
Mechanism is used to resist the force of helical spring 47 and cassette loading section 18 is held in accommodated position.
Also, as an example of the structure of the damper of above-mentioned example, or other structures.For example, in above-mentioned example, protecting
The component for being provided in portion 45 and constituting damper is held, but damper can also be set in lid 17 to replace setting in maintaining part 45
Set the component for constituting damper.
Also, in above-mentioned example, for the positioning of the short transverse (Z-direction) orthogonal with the horizontal direction of box 15, according to
The height of the mounting surface of mounting box 15, cassette loading section 18 bearing member 18A is provided.In cassette loading section 18, box 15
It is only supported in the state that its lower surface is placed on bearing member 18A, as long as there is the component for above pushing away box 15 from below, it will be able to
It is moved upward box 15.That is, the keeping box 15 in the state of also allowing for the movement of short transverse (Z-direction) of cassette loading section 18.
Accordingly, with respect to the positioning of the short transverse of box 15, can also by use boxed other components other than load portion 18 from
Box 15 is lifted on bearing member 18A to carry out and instead of carrying out by bearing member 18A.Positioning as short transverse at this time is used
Other components, such as can be used maintaining part 45.
In maintaining part 45, such as when cassette loading section 18 is located at accommodated position, enter the bearing member of cassette loading section 18
Altitude location portion is set in the opening 33 of 18A.Thus the lower surface of altitude location portion supporting box 15 carries out the height of box 15
Positioning.When cassette loading section 18 is moved to accommodated position from pull-out location, the altitude location portion of maintaining part 45 enters bearing member
The box 15 being placed on bearing member 18A in the opening 33 of 18A climbs onto the altitude location portion of maintaining part 45, thus carries out box
The positioning of 15 short transverse.
In this way, being positioned by other components other than cassette loading section 18 to the height of box 15, thus it is being loaded
When the positioning of short transverse when box 15, also can be obtained can further mitigate the vibration that box 15 is transferred to from cassette loading section 18
Effect.
The present invention being capable of appropriately combined above-mentioned various embodiments or various modifications example.And, however it is not limited to above-mentioned each reality
Mode is applied, without departing from spirit of the invention, then various structures can be used, this is natural.For example, analyte is simultaneously
It is not limited to influenza virus.Or adenovirus, rotavirus, hepatitis virus, pneumococcus etc..Also, immunologic test is not yet
It is limited to qualitative reaction inspection.It moreover, being illustrated by taking immune check device as an example, but may be in addition to immunologic test device
Biosample check device in addition.
Symbol description
10- immunologic test device, 10A- apparatus main body, 15- box, 15A- shell, the side 15B, 15C-, 15D- are engaged
Portion, 16- opening, 17- lid, 17A- hinge, 17B- roller portion, 18- cassette loading section, 18A- bearing member, 18B- framework, 18C- limitation
Portion, 18D- sleeve, 18E- rack gear, 18F- pressed portion, 19- touch panel, 20- point sticky mouth, 21- label, 30- carrier, 31- are surveyed
Region is tried, 32- observation window, 33,34- opening, 35-, which is infused, to be padded, 36- imbibition pad, and 37- restores flow container, and 38- is sensitized flow container, and 43- is surveyed
Determine portion, 45- maintaining part, 45A- guide rail, 45B- bearing portion, 45C- is inserted through hole, 45D, 45E- mounting portion, 46- guide shaft, 46A- anticreep
Portion, 47- helical spring, 48,49- side cover, 48A, 49A- cover portion, the positioning region 48B, 49B-, the holding section 48C, 49C-, 50- light source,
51- image-forming component, 53- pinion gear, 54- load mechanism, 55- base portion, A, B- p-wire, C- control line, the gap G-.
Claims (8)
1. a kind of Biosample check device, wherein have:
Cassette loading section detachably loads the box with the carrier for reacting subject with reagent, and allows the box-packed load
Movement and the holding box in the prescribed limit of the horizontal direction of the box in portion；
Mobile mechanism, the cassette loading section be pressed into and be contained in the accommodated position of the inside of apparatus main body with can be relative to
The cassette loading section loads and unloads the box and the cassette loading section be drawn out in the horizontal direction described device main body outside drawing
Make the cassette loading section mobile between out position；And
Positioning region is not interfered the cassette loading section in the accommodated position and is directly engaged with the box to determine the box
Position.
2. Biosample check device according to claim 1, wherein
The cassette loading section there is the bearing member for loading the box and be set to the bearing member and with the institute on the bearing member
The limiting unit that box abuts and limits the movement beyond prescribed limit in the horizontal direction of the box on the bearing member is stated,
By the gap ensured between the limiting unit and the box, the level side of the box in the cassette loading section is allowed
To prescribed limit in movement.
3. Biosample check device according to claim 1, wherein
The positioning region has respectively and two of the width direction of box orthogonal with the moving direction of the cassette loading section, described
A pair of of holding section of side engaging.
4. Biosample check device according to claim 3, wherein
The holding section is convex, and the spill engaged with the holding section is equipped in two sides of the width direction of the box
Engaged part.
5. Biosample check device according to any one of claim 1 to 4, wherein have lid, which is to cover
The lid being opened and closed between the closed position of load port equipped with the cassette loading section and the open position for opening the load port
Portion, and when cover is mobile to the closed position from the open position, abuts with the cassette loading section and from the pull-out position
It sets towards the accommodated position and is pressed into the cassette loading section.
6. Biosample check device according to any one of claim 1 to 4, wherein have force section, to the box
Loading part exerts a force towards the pull-out location.
7. Biosample check device according to claim 6, wherein have damper, the work for the force section of decaying
Firmly.
8. Biosample check device according to any one of claim 1 to 4, wherein
The subject is liquid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017-163034 | 2017-08-28 | ||
| JP2017163034A JP6768610B2 (en) | 2017-08-28 | 2017-08-28 | Biological sample inspection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109425737A true CN109425737A (en) | 2019-03-05 |
Family
ID=65514705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810969888.8A Pending CN109425737A (en) | 2017-08-28 | 2018-08-23 | Biosample check device |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6768610B2 (en) |
| CN (1) | CN109425737A (en) |
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| CN205049485U (en) * | 2015-09-29 | 2016-02-24 | 宁波大学 | On -board sea / on -vehicle land biochip detecting system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4216434B2 (en) * | 2000-02-02 | 2009-01-28 | 大塚製薬株式会社 | Test strip measuring device |
| JP4205532B2 (en) * | 2003-08-26 | 2009-01-07 | 株式会社鷺宮製作所 | Component measurement / analysis device and sample plate for component measurement / analysis device |
| GB0715171D0 (en) * | 2007-08-03 | 2007-09-12 | Enigma Diagnostics Ltd | Sample processor |
| KR20160056196A (en) * | 2014-11-11 | 2016-05-19 | 삼성전자주식회사 | Test apparatus and control method thereof |
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| JPH09509047A (en) * | 1993-12-17 | 1997-09-16 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Automatic culture and imaging device for disposable microbial incubator |
| JPH08124257A (en) * | 1994-10-20 | 1996-05-17 | Mitsubishi Electric Corp | Cassette-loading apparatus |
| JPH08304412A (en) * | 1995-05-09 | 1996-11-22 | Toa Medical Electronics Co Ltd | Slide glass housing apparatus |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2019039853A (en) | 2019-03-14 |
| JP6768610B2 (en) | 2020-10-14 |
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