CN109394728A - A kind of humidity stimulating responsive intelligent polymer microcapsule and preparation method thereof - Google Patents
A kind of humidity stimulating responsive intelligent polymer microcapsule and preparation method thereof Download PDFInfo
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- CN109394728A CN109394728A CN201811636014.7A CN201811636014A CN109394728A CN 109394728 A CN109394728 A CN 109394728A CN 201811636014 A CN201811636014 A CN 201811636014A CN 109394728 A CN109394728 A CN 109394728A
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- humidity
- polymer microcapsule
- intelligent polymer
- stimulating responsive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Abstract
The invention belongs to polymer microcapsule technical fields, especially the invention discloses a kind of humidity stimulating responsive intelligent polymer microcapsules and preparation method thereof, raw material including following parts by weight: 0.3-0.8 parts of initiator, 0.25-0.50 parts of crosslinking agent, 120-150 parts of dehydrated alcohol, 1-3 parts of aldehyde monomers, 1-3 parts of surfactant, 10-15 parts of polyvinyl alcohol, 15-20 parts of soluble alginate, 5-8 parts of rare earth compounding, 5-8 parts of polyethylene glycol, 90-110 parts of polyacrylic resin, by above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, it is put into ultrasonator oscillation 1-1.5h after mixing evenly and reaches uniform mixing.The present invention is ingenious in design, and reasonable composition, method is reasonable, is suitble to promote the use of.
Description
Technical field
The present invention relates to polymer microcapsule technical field more particularly to a kind of humidity stimulating responsive intelligent polymer microcapsules
And preparation method thereof.
Background technique
Load and delivery systme for drug, researchers both domestic and external always all find one kind can be straight by drug
Intelligent's internal lesions position is picked, the delivery system (Drug without other positions of human body are generated with toxic side effect
Delivery System, DDS).It is smaller from the size of Tanaka in 1978 et al. discovery hydrogel, reach swelling or shrinks flat
After the time of weighing apparatus is shorter, the environmental factors such as temperature, pH value can be made with stimuli responsive and partial size scale in the micron-scale or nanometer
The intelligent microgel of grade just becomes very powerful and exceedingly arrogant research favorite, and such as in 1986, Canadian Pelton just takes the lead in reporting
The development of intelligent microgel opens the research boom of intelligent microgel.Most studied in intelligent microgel is exactly temperature
Stimulating responsive microgel, such as Chinese patent No.1212342C and No.1275999C and United States Patent (USP)
The report of No.2004156906.But they have inevitably used sapn (Span) and tween (Tween) etc. to emulsify
Agent, and make solvent with toxic organic compounds such as toluene, using for these nuisances include multiple water in preparation process
Wash separation and etc., higher cost.And part researcher effectively improves using after surfactant- free emulsion polymerization and prepares environment,
But obtained microgel shrinks smaller, partial size is larger, and stability it is poor (such as document: Polymer Intemational,
2005,54:83, Materials Letters, 2004,58:3400).In addition to temperature stimuli-responsive microgel, pH, light or
The research of the stimulating responsives microgels such as specific ion identification also obtains greater advance.Since human physiological environment is extremely complex,
It is micro- can be generated the intelligence responded by larger limitation to multiple stimulation simultaneously for the application of this single stimulating responsive microgel
The research of gel is paid high attention in recent years, wherein most studied is that temperature and pH value stimuli-responsive are micro- solidifying
Glue, this is because temperature and pH value are most common also most labile environmental conditions in human body environment.
Existing intelligent polymer microcapsule does not have humidity stimulating responsive, for this purpose, the present invention proposes a kind of humidity stimulation
Responsive intelligent polymer microcapsule and preparation method thereof.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of humidity stimulating responsive proposed
Intelligent polymer microcapsule and preparation method thereof.
To achieve the goals above, present invention employs following technical solutions:
A kind of humidity stimulating responsive intelligent polymer microcapsule, the raw material including following parts by weight: 0.3-0.8 parts of initiator is handed over
Join agent 0.25-0.50 parts, 120-150 parts of dehydrated alcohol, 1-3 parts of aldehyde monomers, 1-3 parts of surfactant, polyvinyl alcohol 10-15
Part, 15-20 parts of soluble alginate, 5-8 parts of rare earth compounding, 5-8 parts of polyethylene glycol, 90-110 parts of polyacrylic resin.
Preferably, the crosslinking agent is N, N- methylene-bisacrylamide.
Preferably, the rare earth compounding includes EuCl 6HO, TmCl 6HO, ErCl 6HO, SmCl 6HO, GdCl 6HO
One or more of.
Preferably, the soluble alginate includes one of sodium alginate, potassium alginate and ammonium alginate or several
Kind.
Preferably, the initiator is benzoyl peroxide formaldehyde, azodiisobutyronitrile, ammonium persulfate-tetramethylethylenediamine, mistake
One of potassium sulfate-sodium sulfite.
Preferably, the raw material including following parts by weight: 0.5 part of initiator, 0.35 part of crosslinking agent, 135 parts of dehydrated alcohol, aldehyde
2 parts of class monomer, 2 parts of surfactant, 12.5 parts of polyvinyl alcohol, 17.5 parts of soluble alginate, 6.5 parts of rare earth compounding,
6.5 parts of polyethylene glycol, 100 parts of polyacrylic resin.
A kind of preparation method of humidity stimulating responsive intelligent polymer microcapsule, includes the following steps,
Above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, are put into after mixing evenly by S1
Ultrasonator oscillation 1-1.5h reaches uniform mixing；
S2, at room temperature, add initiator, crosslinking agent, surfactant, polyvinyl alcohol, soluble alginate and
Polyethylene glycol, then carry out arrest reaction 45-50min；
Intelligent polymer microcapsule is made after washing, drying in S3.
Compared with prior art, the beneficial effects of the present invention are: preparation method is simple and convenient to operate；Has good biological
The features such as compatibility, biological degradability and nontoxicity；Partial size is small, has humidity stimulating responsive, and hygrometric state resistivity is 10000 Ω
Cm, resistivity when dry state are that 100 Ω cm have dropped 100 times, contraction/stretching, extension of this and conductive network during change of moisture content
The on/off of circuit is caused to have substantial connection, the present invention is ingenious in design, and reasonable composition, method is reasonable, is suitble to promote the use of.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment one
A kind of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, the raw material including following parts by weight: initiator
0.3 part, it is 0.25 part of crosslinking agent, 120 parts of dehydrated alcohol, 1 part of aldehyde monomers, 1 part of surfactant, 10 parts of polyvinyl alcohol, solvable
Property 15 parts of alginate, 5 parts of rare earth compounding, 5 parts of polyethylene glycol, 90 parts of polyacrylic resin.
A kind of preparation method of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, includes the following steps,
Above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, are put into after mixing evenly by S1
Ultrasonator oscillation 1h reaches uniform mixing；
S2, at room temperature, add initiator, crosslinking agent, surfactant, polyvinyl alcohol, soluble alginate and
Polyethylene glycol, then carry out arrest reaction 45min；
Intelligent polymer microcapsule is made after washing, drying in S3.
Embodiment two
A kind of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, the raw material including following parts by weight: initiator
0.5 part, 0.35 part of crosslinking agent, 135 parts of dehydrated alcohol, 2 parts of aldehyde monomers, 2 parts of surfactant, 12.5 parts of polyvinyl alcohol, can
17.5 parts of solubility alga hydrochlorate, 6.5 parts of rare earth compounding, 6.5 parts of polyethylene glycol, 100 parts of polyacrylic resin.
A kind of preparation method of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, includes the following steps,
Above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, are put into after mixing evenly by S1
Ultrasonator oscillation 1.5h reaches uniform mixing；
S2, at room temperature, add initiator, crosslinking agent, surfactant, polyvinyl alcohol, soluble alginate and
Polyethylene glycol, then carry out arrest reaction 50min；
Intelligent polymer microcapsule is made after washing, drying in S3.
Embodiment three
A kind of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, the raw material including following parts by weight: initiator
0.8 part, it is 0.50 part of crosslinking agent, 150 parts of dehydrated alcohol, 3 parts of aldehyde monomers, 3 parts of surfactant, 15 parts of polyvinyl alcohol, solvable
Property 20 parts of alginate, 8 parts of rare earth compounding, 8 parts of polyethylene glycol, 110 parts of polyacrylic resin.
A kind of preparation method of humidity stimulating responsive intelligent polymer microcapsule proposed by the present invention, includes the following steps,
Above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, are put into after mixing evenly by S1
Ultrasonator oscillation 1.5h reaches uniform mixing；
S2, at room temperature, add initiator, crosslinking agent, surfactant, polyvinyl alcohol, soluble alginate and
Polyethylene glycol, then carry out arrest reaction 50min；
Intelligent polymer microcapsule is made after washing, drying in S3.
Compared with prior art, the beneficial effects of the present invention are: preparation method is simple and convenient to operate；Has good biological
The features such as compatibility, biological degradability and nontoxicity；Partial size is small, has humidity stimulating responsive, and hygrometric state resistivity is 10000 Ω
Cm, resistivity when dry state are that 100 Ω cm have dropped 100 times, contraction/stretching, extension of this and conductive network during change of moisture content
The on/off of circuit is caused to have substantial connection, the present invention is ingenious in design, and reasonable composition, method is reasonable, is suitble to promote the use of.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. a kind of humidity stimulating responsive intelligent polymer microcapsule, which is characterized in that the raw material including following parts by weight: initiator
0.3-0.8 parts, 0.25-0.50 parts of crosslinking agent, 120-150 parts of dehydrated alcohol, 1-3 parts of aldehyde monomers, 1-3 parts of surfactant,
10-15 parts of polyvinyl alcohol, 15-20 parts of soluble alginate, 5-8 parts of rare earth compounding, 5-8 parts of polyethylene glycol, polyacrylic acid
90-110 parts of resin.
2. a kind of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, which is characterized in that the crosslinking
Agent is N, N- methylene-bisacrylamide.
3. a kind of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, which is characterized in that the rare earth
Complex includes one or more of EuCl6HO, TmCl6HO, ErCl6HO, SmCl6HO, GdCl6HO.
4. a kind of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, which is characterized in that described solvable
Property alginate includes one or more of sodium alginate, potassium alginate and ammonium alginate.
5. a kind of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, which is characterized in that the initiation
Agent is benzoyl peroxide formaldehyde, azodiisobutyronitrile, ammonium persulfate-tetramethylethylenediamine, one in potassium peroxydisulfate-sodium sulfite
Kind.
6. a kind of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, which is characterized in that including following
The raw material of parts by weight: 0.5 part of initiator, 0.35 part of crosslinking agent, 135 parts of dehydrated alcohol, 2 parts of aldehyde monomers, surfactant 2
Part, 12.5 parts of polyvinyl alcohol, 17.5 parts of soluble alginate, 6.5 parts of rare earth compounding, 6.5 parts of polyethylene glycol, polyacrylic acid
100 parts of resin.
7. a kind of preparation method of humidity stimulating responsive intelligent polymer microcapsule according to claim 1, feature exist
In, include the following steps,
Above-mentioned polyacrylic resin, rare earth compounding, aldehyde monomers are put into dehydrated alcohol, are put into after mixing evenly by S1
Ultrasonator oscillation 1-1.5h reaches uniform mixing；
S2, at room temperature, add initiator, crosslinking agent, surfactant, polyvinyl alcohol, soluble alginate and
Polyethylene glycol, then carry out arrest reaction 45-50min；
Intelligent polymer microcapsule is made after washing, drying in S3.
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| CN201811636014.7A CN109394728A (en) | 2018-12-29 | 2018-12-29 | A kind of humidity stimulating responsive intelligent polymer microcapsule and preparation method thereof |
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| CN201811636014.7A CN109394728A (en) | 2018-12-29 | 2018-12-29 | A kind of humidity stimulating responsive intelligent polymer microcapsule and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101382484A (en) * | 2008-06-24 | 2009-03-11 | 沈阳建筑大学 | Conductivity hydrogels composite material sensitized to humidity variation |
| CN101838375A (en) * | 2010-04-23 | 2010-09-22 | 东华大学 | Temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof |
-
2018
- 2018-12-29 CN CN201811636014.7A patent/CN109394728A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101382484A (en) * | 2008-06-24 | 2009-03-11 | 沈阳建筑大学 | Conductivity hydrogels composite material sensitized to humidity variation |
| CN101838375A (en) * | 2010-04-23 | 2010-09-22 | 东华大学 | Temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof |
Non-Patent Citations (2)
| Title |
|---|
| 南静娅，等: "聚N-异丙基丙烯酰胺-聚丙烯酸微胶囊的制备", 《第四届全国生物质材料科学与技术学术研讨会论文集》 * |
| 方亮: "《全国高等医药院校药学类第四轮规划教材 药剂学 第3版》", 31 March 2016, 北京：中国医药科技出版社 * |
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