CN109394288A - Closing in inside-out cladding process - Google Patents

Closing in inside-out cladding process Download PDF

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Publication number
CN109394288A
CN109394288A CN201811419301.2A CN201811419301A CN109394288A CN 109394288 A CN109394288 A CN 109394288A CN 201811419301 A CN201811419301 A CN 201811419301A CN 109394288 A CN109394288 A CN 109394288A
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CN
China
Prior art keywords
cylinder
reticulate body
thin
thin cylinder
body cylinder
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201811419301.2A
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Chinese (zh)
Other versions
CN109394288B (en
Inventor
董何彦
蒋义
胡义平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liaoning Yinyi Biotechnology Co Ltd
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Liaoning Yinyi Biotechnology Co Ltd
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Priority to CN201811419301.2A priority Critical patent/CN109394288B/en
Publication of CN109394288A publication Critical patent/CN109394288A/en
Application granted granted Critical
Publication of CN109394288B publication Critical patent/CN109394288B/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12177Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses a kind of closing in inside-out cladding process, and in particular to a kind of method that small reticulate body cylinder is covered by thin drum surface.Thin cylinder is carefully thin, and reticulate body cylinder is inserted directly into conventional method with the nozzle of opening and does not accomplish ideal installation.Present invention employs closing in inside-out cladding process, i.e. two put in opposite directions on the same axis, reticulate body cylinder covers outside thin cylinder, after circumference posts, reticulate body cylinder is mobile to thin cylinder bore, under the premise of tight mouth is not loose, coaxially touch, it observes thin cylinder to be covered on reticulate body cylinder, reticulate body cylinder is gradually all pushed into thin cylinder.Only the original port of thin cylinder has had changed into tail mouth, and inner surface, which has turned over, to be come out, and becomes outer surface, and the smooth patch in original outer surface covers the outer surface in reticulate body cylinder.Method automatic outside two tight mouths to unclamp, completing the not damaged covering of thin cylinder to small reticulate body cylinder.

Description

Closing in inside-out cladding process
Technical field
The present invention relates to medical instruments field, especially a kind of closing in inside-out cladding process.
Background technique
Currently, netted bodily form bracket is the main method for treating hemadostewnosis or blockage pathology.But the treatment method is deposited In defect --- it can not effectively treat aneurysm or angiorrhoxis.The reticulate body of thin cylinder covering is to make up above-mentioned drawback, effectively It treats hemadostewnosis or blockage pathology, aneurysm or angiorrhoxis provides new solution.Existing thin cylinder on the market Covering reticulate body is divided into following two major classes:
1, the thin cylinder that thin drum type brake is pressed from both sides among two layers of reticulate body covers reticulate body: can make to produce since two layers of netted weight is folded The flexibility of product is poor, outer diameter is also bigger, is difficult through diseased region, can not be expected to use;After reticulate body expansion, because of overlapping The three-point bending of reticulate body is larger, and reticulate body is poor to the followability of blood vessel, be easy to cause reticulate body adherent bad, there are safety Hidden danger.
2, thin cylinder be seamed to reticulate body surface thin cylinder covering reticulate body: suture thin cylinder covering reticulate body also compared with Firmly, and thin cylinder is generally partially thick, not good enough to the followability of blood vessel, be easy to cause reticulate body adherent bad, there are security risks; Also, suture often occurs leaking blood phenomenon, and suture stimulates body to generate inflammation and thrombus, is unable to reach expected treatment effect Fruit.
Summary of the invention
In view of this, thin cylinder covering obtained is netted the object of the present invention is to provide a kind of closing in inside-out cladding process Body cylinder flexibility is good, and outer diameter is small, good to the followability of blood vessel, does not leak blood, not will cause that bracket is adherent bad or inflammatory reaction, benefit In the treatment for diseases of patient.
To achieve the goals above, the invention provides the following technical scheme:
A kind of closing in inside-out cladding process, comprising the following steps:
A) thin cylinder is separated
The insertion end of liner is penetrated from one end of thin cylinder, makes thin cylinder uniform expansion, it, will be interior after all penetrating Lining and thin cylindrical portions are dismissed;
B) thin cylinder covering
Reticulate body cylinder and thin cylinder are put in opposite directions on the same axis, and reticulate body cylinder covers outside thin cylinder, and circumference posts Afterwards, reticulate body cylinder is mobile to thin cylinder bore, it under the premise of tight mouth is not loose, coaxially touches, observes thin cylinder and be covered in net On shape body cylinder, reticulate body cylinder is gradually all pushed into thin cylinder.It is automatic outside two tight mouths to unclamp.
Preferably, the thin cylinder with a thickness of 10 μm~500 μm.
Preferably, the material of the thin cylinder is polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, polypropylene, gathers One of ester, polyvinyl chloride, polyurethane, polyphenyl alkene, nylon, nylon elastomer, polyurethane, carbon fiber are more Kind.
Preferably, the thin cylinder is the tubulose that seamless tubular shaped, seamed tubulose or thin slice are rolled into.
Preferably, the material of the reticulate body cylinder is one of metal, carbon fiber, polymer, resin or a variety of.
Preferably, the shape of the reticulate body cylinder is isometrical, variable diameter or waney tubular.
Preferably, the reticulate body cylinder outer diameter is 1mm~80mm.
Preferably, the length of the reticulate body cylinder is 4mm~100mm.
Preferably, reticulate body cylinder surface is covered with coating or does not cover coating;When reticulate body cylinder surface is covered with coating, The coating be active medicine, inert pharmaceutical, ceramics, carry medicine matrix, polymer one or more or reticulate body cylinder surface without Coating.
Preferably, the insertion end is to be cut into diamond shape, triangle, trapezoidal, shuttle shape, ellipse, olive shape, spindle or wave The insertion end of shape wave.
The present invention provides a kind of closing in inside-out cladding process, liner can not damaged as the mandrel for separating thin cylinder Hurt and uniformly separates thin cylinder under conditions of thin cylinder.Reticulate body cylinder covers outside thin cylinder, after circumference posts, by reticulate body cylinder It is mobile to thin cylinder bore, it under the premise of tight mouth is not loose, coaxially touches, observes thin cylinder and be covered on reticulate body cylinder, net Shape body cylinder is gradually all pushed into thin cylinder.Only the original port of thin cylinder has had changed into tail mouth, and inner surface turns over Out, become outer surface, and the smooth patch in original outer surface covers the outer surface in reticulate body cylinder.Automatic pine outside two tight mouths It opens, the method for completing the not damaged covering of thin cylinder to small reticulate body cylinder.The thin cylinder covering reticulate body cylinder of support is like wound Can paste it is general it is quick, accurately and efficiently block the vascular injury sites such as angiorrhoxis or hemangioma, save artery in time The life of the vascular diseases such as tumor or angiorrhoxis.The combination of thin cylinder and reticulate body cylinder is strong in thin cylinder covering reticulate body cylinder Degree is high, and the inter-molecular attraction of thin cylinder and coating is strong, good to the followability of blood vessel, conducive to the treatment for diseases of patient.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of liner
Fig. 2 is the structural schematic diagram that thin cylinder covers reticulate body cylinder made from announcement method of the present invention.
In figure:
1, liner;2, thin cylinder;3, coating;4, reticulate body cylinder.
Specific embodiment
A kind of closing in inside-out cladding process provided by the invention, comprising the following steps:
A) thin cylinder 2 is separated
The insertion end of liner 1 is penetrated from one end of thin cylinder 2, makes thin 2 uniform expansion of cylinder, after all penetrating, Liner 1 and 2 part of thin cylinder are dismissed;
B) thin cylinder 2 covers
Reticulate body cylinder 4 and thin cylinder 2 are opposite on the same axis and put, 4 sets of reticulate body cylinder outside thin cylinder 2, circumference patch It is after getting togather, reticulate body cylinder 4 is mobile to thin 2 inner cavity of cylinder, it under the premise of tight mouth is not loose, coaxially touches, until thin 2 quilt of cylinder It covers on reticulate body cylinder 4, reticulate body cylinder 4 is gradually all pushed into thin cylinder 2;It is automatic outside two tight mouths to unclamp.
In above-mentioned technical proposal, liner 1, can be under conditions of not damaging thin cylinder 2 as the mandrel for separating thin cylinder 2 By the thin uniformly separation of cylinder 2.4 sets of reticulate body cylinder outside thin cylinder 2, after circumference posts, by reticulate body cylinder 4 into thin cylinder 2 Chamber is mobile, under the premise of tight mouth is not loose, coaxially touches, until thin cylinder 2 is covered on reticulate body cylinder 4, reticulate body cylinder 4 by Gradually all it is pushed into thin cylinder 2.Only the original port of thin cylinder 2 has had changed into tail mouth, and inner surface, which has turned over, to be come out, and becomes At outer surface, and the smooth patch in original outer surface covers the outer surface in reticulate body cylinder 4.It is automatic outside two tight mouths to unclamp, it is complete At the method for the not damaged covering of thin cylinder 2 to small reticulate body cylinder 4.The thin cylinder 2 of support covers reticulate body cylinder 4 like wound can Patch is generally quick, accurately and efficiently blocks the vascular injury sites such as angiorrhoxis or hemangioma, saves vascular aneurysms in time Or the life of the vascular diseases such as angiorrhoxis.Thin cylinder 2 covers the combination of thin cylinder 2 and reticulate body cylinder 4 in reticulate body cylinder 4 Intensity is high, and the inter-molecular attraction of thin cylinder 2 and coating 3 is strong, good to the followability of blood vessel, conducive to the treatment for diseases of patient.
Fig. 2 shows the method for closing in inside-out covering of the present invention, and it includes reticulate body which, which covers reticulate body cylinder 4, 4, coating 3 and thin cylinder 2.
In the present invention, liner 1 is made: 1 one end of liner is cut into certain shapes to get the insertion end of liner 1;In addition, In the embodiment of the present invention, the shape of insertion end is diamond shape, triangle, trapezoidal, shuttle shape, ellipse, olive shape, spindle, wave One of shape wave.
In the present invention, it separates thin cylinder 2: liner 1 is penetrated from one end of thin cylinder 2, play thin 2 uniform expansion of cylinder Come, after all penetrating, liner 1 and 2 part of thin cylinder are dismissed.In addition, in an embodiment of the present invention, the wall thickness of thin cylinder 2 It is 10 μm~500 μm.The material of thin cylinder 2 is polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, polypropylene, polyester, gathers One of vinyl chloride, polyurethane, polyphenyl alkene, nylon, nylon elastomer, polyurethane, carbon fiber are a variety of.
It cuts thin cylinder 2: thin 2 part of cylinder obtained above being cut, the thin cylinder 2 handled well;In addition, in this hair In bright embodiment, thin cylinder 2 is the tubulose that seamless tubular shaped, seamed tubulose or thin slice are rolled into.
Thin cylinder 2 covers: 4 sets of reticulate body cylinder outside thin cylinder 2, after circumference posts, by reticulate body cylinder 4 to thin cylinder 2 Inner cavity is mobile, under the premise of tight mouth is not loose, coaxially touches, until thin cylinder 2 is covered on reticulate body cylinder 4, reticulate body cylinder 4 Gradually all it is pushed into thin cylinder 2, it is automatic outside two tight mouths to unclamp.In addition, in an embodiment of the present invention, reticulate body The material of cylinder 4 is one of metal, carbon fiber, polymer, resin or a variety of.The shape of reticulate body cylinder 4 be isometrical, variable diameter or Waney tubular.The minimum outer diameter of reticulate body cylinder 4 is 1mm~80mm.The minimum length of reticulate body cylinder 4 is 4mm~100mm.
Coating 3: in an embodiment of the present invention, 4 surface of reticulate body cylinder can not also cover coating 3 with applying coating 3; Be covered with coating 3, coating 3 be active medicine, inert pharmaceutical, ceramics, carry medicine matrix, polymer it is one or more.
In order to further illustrate the present invention, below with reference to embodiment to a kind of closing in inside-out cladding process provided by the invention It is described in detail, but they cannot be interpreted as limiting the scope of the present invention.
A) thin cylinder 2 is separated
The liner 1 that one end is cut into certain shapes is penetrated from one end of thin cylinder 2, makes thin 2 uniform expansion of cylinder, entirely After portion penetrates, liner 1 and 2 part of thin cylinder are dismissed;
B) thin cylinder 2 covers
Reticulate body cylinder 4 and thin cylinder 2 are put in opposite directions on the same axis, and mouth mouth is affixed, and 4 sets of reticulate body cylinder in thin cylinder 2 Outside, after circumference posts, reticulate body cylinder 4 is mobile to thin 2 inner cavity of cylinder, under the premise of tight mouth is not loose, coaxially touch, until Thin cylinder 2 is covered on reticulate body cylinder 4, and reticulate body cylinder 4 is gradually all pushed into thin cylinder 2;Outside two tight mouths certainly It is dynamic to unclamp.
The prepared thin cylinder 2 of the present embodiment covers the bond strength of thin cylinder 2 and reticulate body cylinder 4 in reticulate body cylinder 4 Height, 3 substance of coating, such as active medicine, inert pharmaceutical, ceramics, the intermolecular Van der Waals for carrying medicine matrix, polymer substance Power is relatively strong, it and thin cylinder 2, as polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, polypropylene, polyester, polyvinyl chloride, There are biggish electrically absorption between the substances such as polyurethane, polyphenyl alkene, nylon, nylon elastomer, polyurethane, carbon fiber Power, the movement of electronics generates instantaneous dipole moment in 3 molecule of coating, it makes 2 molecule of thin cylinder closed on instantaneously polarize, and the latter is again anti- Come over to enhance the instantaneous dipole moment of original molecule;This intercouple generates net sucking action, and Van der Waals for has Have additive property, belong to secondary key, along between coating 3 and thin cylinder 2 hydrophobic forces and sedimentation, make reticulate body cylinder 4 It is firmly combined with thin cylinder 2, it is good to the followability of blood vessel, conducive to the treatment for diseases of patient.
Above description can be realized professional and technical personnel in the field or using this to stating in the disclosed embodiments It is bright, it enables those skilled in the art to implement or use the present invention.Various modifications to these embodiments are to this field It will be apparent for professional technician, the general principles defined herein can not depart from spirit of the invention Or in the case where range, realize in other embodiments.Therefore, the present invention is not intended to be limited to these implementations shown in this article Example, and it is to fit to the widest scope consistent with principles disclosed herein and novel features.

Claims (10)

1. a kind of closing in inside-out cladding process, which comprises the following steps:
A) thin cylinder is separated
The insertion end of liner is penetrated from one end of thin cylinder, makes thin cylinder uniform expansion, after all penetrating, by liner Thin cylinder corresponding to insertion end and insertion end is dismissed;
B) thin cylinder covering
Reticulate body cylinder and thin cylinder are put in opposite directions on the same axis, and reticulate body cylinder covers outside thin cylinder, will after circumference posts Reticulate body cylinder is mobile to thin cylinder bore, under the premise of tight mouth is not loose, coaxially touches, until thin cylinder is covered in reticulate body cylinder On, reticulate body cylinder is gradually all pushed into thin cylinder;It is automatic outside two tight mouths to unclamp.
2. closing in inside-out cladding process as described in claim 1, which is characterized in that the thin cylinder with a thickness of 10 μm~ 500μm。
3. closing in inside-out cladding process as described in claim 1, which is characterized in that the material of the thin cylinder is polytetrafluoroethyl-ne Alkene, expanded PTFE, polyethylene, polypropylene, polyester, polyvinyl chloride, polyurethane, polyphenyl alkene, nylon, nylon elastomer, One of polyurethane, carbon fiber are a variety of.
4. closing in inside-out cladding process as described in claim 1, which is characterized in that the thin cylinder is seamless tubular shaped, seamed The tubulose that tubulose or thin slice are rolled into.
5. closing in inside-out cladding process as described in claim 1, which is characterized in that the material of the reticulate body cylinder be metal, One of carbon fiber, polymer, resin are a variety of.
6. closing in inside-out cladding process as claimed in claim 5, which is characterized in that the shape of the reticulate body cylinder be it is isometrical, Variable diameter or waney tubular.
7. closing in inside-out cladding process as claimed in claim 5, which is characterized in that the reticulate body cylinder outer diameter be 1mm~ 80mm。
8. closing in inside-out cladding process as claimed in claim 5, which is characterized in that the length of the reticulate body cylinder be 4mm~ 100mm。
9. the method as described in claim 1, which is characterized in that reticulate body cylinder surface is covered with coating or does not cover coating;Institute When stating reticulate body cylinder surface and being covered with coating, the coating be active medicine, inert pharmaceutical, ceramics, carry medicine matrix, polymer one Kind or a variety of or reticulate body cylinder surface are uncoated.
10. closing in inside-out cladding process as described in claim 1, which is characterized in that the insertion end is to be cut into diamond shape, triangle Shape, trapezoidal, shuttle shape, ellipse, olive shape, spindle or wavy insertion end.
CN201811419301.2A 2018-11-26 2018-11-26 Binding-up, inward turning and outer covering method Active CN109394288B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN109394288B CN109394288B (en) 2021-12-03

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203616A1 (en) * 1996-12-31 2005-09-15 Alain Cribier Valve prosthesis for implantation in body channels
CN103857416A (en) * 2011-10-07 2014-06-11 W.L.戈尔及同仁股份有限公司 Puncturable and resealable graft
US20160235525A1 (en) * 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
CN108697519A (en) * 2016-02-09 2018-10-23 宾利-英诺美特有限公司 Release system for self expandable built-in prothesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203616A1 (en) * 1996-12-31 2005-09-15 Alain Cribier Valve prosthesis for implantation in body channels
CN103857416A (en) * 2011-10-07 2014-06-11 W.L.戈尔及同仁股份有限公司 Puncturable and resealable graft
US20160235525A1 (en) * 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
CN108697519A (en) * 2016-02-09 2018-10-23 宾利-英诺美特有限公司 Release system for self expandable built-in prothesis

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