CN109382051B - A kind of production system of nanometer biomedical material and its production process - Google Patents

Abstract

The invention discloses a production system and a production process of a nano biomedical material, belonging to the technical field of medical material production. The production system and the production process of the nano biomedical material not only can produce the nano biomedical material safely and reliably, but also can effectively meet the requirement that the corresponding nano biomedical material cannot be produced at home at present.

Description

A kind of production system of nanometer biomedical material and its production process

technical field

The invention relates to the technical field of medical material production, in particular to a production system and a production process of nanometer biomedical material.

Background technique

At present, nano-biomedical materials have a very significant effect in assisting biological detection and diagnosis. However, based on nano-biomedical materials, there is currently no relevant industrialized production system and production process on the market. Therefore, there is an urgent need for a production system and production process that can produce nano-biomedical materials.

In view of the above-mentioned defects, the creator of the present invention finally obtained the present invention after a long period of research and practice.

SUMMARY OF THE INVENTION

In view of this, the present invention aims to propose a production system and production process of nano-biomedical materials, which can solve the problem that there is no production system and production process for producing nano-biomedical materials on the market.

In order to achieve the above object, the technical scheme of the present invention is achieved in this way:

A production system for nano-biomedical materials, comprising a reactor, an electromagnetic separator, a tubular centrifuge, a first membrane separator, a second membrane separator, and a vacuum distillation column;

The reaction kettle is used for preparing magnetic particles, fine-processing the magnetic particles, and organically coating the magnetic particles after the fine-processing;

The electromagnetic separator is used to separate the magnetic particles prepared in the reaction kettle from the reaction liquid;

The tubular centrifuge: used to remove magnetic particles that do not meet the particle size requirements after fine treatment;

The first membrane separator: used to remove magnetic particles that do not meet the molecular weight requirements after refining;

The second membrane separator: used to remove magnetic particles that do not meet the molecular weight requirements after organic coating;

The vacuum distillation column: used to concentrate the magnetic particles that meet the particle size requirements and the molecular weight requirements after organic encapsulation.

Further, the first liquid outlet of the reaction kettle is respectively connected with the liquid inlet of the electromagnetic separator, the liquid inlet of the tubular centrifuge, and the liquid inlet of the second membrane separator; the electromagnetic separator The liquid outlet is connected to the second liquid inlet of the reactor;

The liquid outlet of the tubular centrifuge is connected to the liquid inlet of the first membrane separator, and the liquid outlet of the first membrane separator is connected to any liquid inlet of the reactor; the second The liquid outlet of the membrane separator is connected with the liquid inlet of the vacuum distillation column.

Further, the top of the electromagnetic separator is also provided with a spray device for washing the magnetic particles.

Further, the electromagnetic separator also includes an adjustable electromagnetic intensity device.

Utilize the production process of the production system of any of the above-mentioned nano biomedical materials, comprising the following steps:

S1, the raw materials that need to be configured are added to the reaction kettle according to a certain proportion, and the reaction solution containing nano-scale magnetic particles is prepared by the reaction of the reaction kettle;

S2, the reaction kettle will prepare the reaction liquid containing nano-scale magnetic particles and send it to the electromagnetic separator, carry out the magnetic separation of the liquid and the nano-scale magnetic particles, and discharge the separated liquid; the electromagnetic separator continues to wash liquid to wash all nano-scale magnetic particles;

S3. After the electromagnetic separator discharges the washed washing liquid, the electricity is stopped and the backflushing liquid is passed into it to elute the nano-scale magnetic particles from the wall of the electromagnetic separator. The magnetic particle reaction liquid is returned to the reaction kettle for fine processing;

S4. The refined reaction solution containing magnetic nanoparticles is sent to a tubular centrifuge, and the magnetic nanoparticles that do not meet the particle size specifications are removed by centrifugation;

S5, the tubular centrifuge sends the remaining magnetic nanoparticle reaction liquid meeting the particle size requirements to the first membrane separator to remove the magnetic nanoparticles that do not meet the molecular weight requirements;

S6, the first membrane separator returns the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to the reaction kettle, and is covered with a polymer material;

S7, the reaction kettle sends the coated magnetic nanoparticle reaction solution to the second membrane separator to remove the magnetic nanoparticles that do not meet the molecular weight requirements;

S8. The second membrane separator sends the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to a vacuum distillation tower for concentration, and after reaching a specified concentration, the production is completed.

Further, the stirring speed of the reaction kettle in the steps S1 and S3 is: 500-2000 rpm, the stirring time is: 30-360 min, and the temperature range is: room temperature to 80°C.

Further, the intensity range of the magnetic field in the electromagnetic separator in the step S2 is: 2000-10000 Gauss.

Further, the rotational speed range of the tubular centrifuge in the step S4 is 4000-6000 rpm.

Further, the stirring speed of the reaction kettle in the step S6 is: 200-1000 rpm, the stirring time is 30-360 min, and the temperature range is: room temperature to 80°C.

Further, the temperature range of the vacuum distillation column in the step S8 is: 60-70°C.

Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The production system for obtaining nano-biomedical materials according to the present invention and the production process thereof not only produce safe and reliable nano-biomedical materials, but also can effectively solve the problems that cannot be achieved in China. The demand for the production of corresponding nano-medical biomaterials. 2. The production system of the nano-biomedical material of the present invention is simple and easy to control; it can effectively reduce the cost of enterprises or users. 3. The nano biomedical material production system and its production process according to the present invention can not only achieve precise and refined processing, but also can effectively improve the quality qualification rate of the produced materials.

Description of drawings

In order to illustrate the technical solutions in the various embodiments of the present invention more clearly, the following briefly introduces the accompanying drawings used in the description of the embodiments.

Fig. 1 is the production system schematic diagram of the embodiment of the present invention;

The numbers in the figure represent:

1. Reactor 2. Electromagnetic Separator 3. Tube Centrifuge 4. First Membrane Separator 5. Second Membrane Separator 6. Vacuum Distillation Column

Detailed ways

The above and other technical features and advantages of the present invention will be described in more detail below with reference to the accompanying drawings.

Example 1

As shown in Figure 1, a production system of nano-biomedical materials includes a reactor 1, an electromagnetic separator 2, a tubular centrifuge 3, a first membrane separator 4, a second membrane separator 5, and a vacuum distillation column 6.

Reactor 1, used for preparing magnetic particles (magnetic particles), refining the magnetic particles and organically coating the refined magnetic particles;

Electromagnetic separator 2: used to separate the magnetic particles prepared in the reactor 1 from the reaction solution;

Tubular centrifuge 3: It is used to remove magnetic particles that do not meet the particle size requirements after refining treatment; it is mainly used to remove magnetic nanoparticles larger than 12 nm.

The first membrane separator 4: used to remove magnetic particles that do not meet the molecular weight requirements after refining treatment; mainly to remove magnetic nanoparticles with a molecular weight of less than 3500.

Second membrane separator 5: used to remove magnetic particles that do not meet the molecular weight requirements after organic coating; mainly remove magnetic nanoparticles with molecular weight greater than 10,000.

Vacuum distillation column 6: used to concentrate the magnetic particles that meet the particle size requirements and the molecular weight requirements after organic encapsulation.

The liquid outlet of the reactor 1 is respectively connected with the liquid inlet of the electromagnetic separator 2, the liquid inlet of the tubular centrifuge 3, and the liquid inlet of the second membrane separator 5, but the liquid inlets of the three are not at the same time. Liquid inlet; when the liquid inlet of the electromagnetic separator 2 or the liquid inlet of the tubular centrifuge 3 or the liquid inlet of the second membrane separator 5 is opened, the other two liquid inlets are closed.

The liquid outlet of the electromagnetic separator 2 is connected to the second liquid inlet of the reactor 1; the positions of the liquid inlet and the liquid outlet of the electromagnetic separator 2 can be set according to actual needs; In and out.

The liquid outlet of the tubular centrifuge 3 is connected to the liquid inlet of the first membrane separator 4 , and the liquid outlet of the first membrane separator 4 is connected to any liquid inlet of the reactor 1 .

The liquid outlet of the second membrane separator 5 is connected to the liquid inlet of the vacuum distillation column 6 .

The above-mentioned reaction kettle 1, electromagnetic separator 2, tubular centrifuge 3, first membrane separator 4, second membrane separator 5, and vacuum distillation tower 6 are all provided with a drain outlet, and the location of the drain outlet is based on the actual situation. You may need to adjust it yourself.

The nano-biomaterials produced by the production system for obtaining nano-biomedical materials of the present invention are not only safe and reliable, but also can effectively meet the current domestic demand that cannot produce corresponding nano-medical biomaterials.

Example 2

The top of the electromagnetic separator 2 is also provided with a spray device for washing the magnetic particles; the spray device can accurately and comprehensively wash all the magnetic particles, and can also save the washing liquid used in washing, effectively Reduce costs for businesses or users.

Example 3

The electromagnetic separator 2 also includes an adjustable electromagnetic strength device. Users can adjust the electromagnetic intensity according to actual needs. The adjustable electromagnetic intensity effectively meets the needs of users to set the electromagnetic intensity by themselves, making the whole system convenient and fast to use.

Example 4

Utilize the technology of a kind of nano biomedical material production system in the above-mentioned embodiment, comprises the following steps:

S1, adding the raw materials to be configured to the reaction kettle 1 according to a certain proportion, and reacting in the reaction kettle 1 to prepare a reaction solution containing nano-scale magnetic particles;

Specifically, after adding the raw materials, the reaction vessel 1 is stirred under normal pressure.

Preferably, the stirring speed of the reaction kettle 1 is: 500-2000 rpm (revolution/min), the stirring time is: 30-360 min, and the temperature range is: room temperature to 80°C.

S2, the reaction kettle 1 sends the prepared reaction solution containing the nano-scale magnetic particles to the feed port of the electromagnetic separator 2, carries out the magnetic separation of the liquid and the nano-scale magnetic particles, and discharges the separated liquid from the liquid outlet; Electromagnetic separator 2 continues to wash all nano-scale magnetic particles by washing liquid;

Specifically, after the reaction liquid containing nano-scale magnetic particles prepared in the reaction kettle 1 enters the electromagnetic separator 2, the electromagnetic separator 2 is energized, and the reaction liquid containing the nano-scale magnetic particles is separated by the electromagnetic separator 2, so that the nano-magnetic particles are separated. Adsorbed on the inner wall of the electromagnetic separator 2 , the remaining reaction liquid is discharged from the liquid discharge port of the electromagnetic separator 2 . Preferably, the magnetic field strength of the electromagnetic separator 2 is set to: 2000 Gauss to 10000 Gauss.

All the reaction liquid passes through the electromagnetic separator 2. After all the magnetic particles are adsorbed, the spray device on the top of the electromagnetic separator is turned on to wash the magnetic particles until the pH value of the discharged liquid reaches 7.

S3. After the washing liquid in the electromagnetic separator 2 is completely drained, the electromagnetic separator 2 is turned off and the backflush is passed into it, so that the nano-scale magnetic particles are eluted from the wall of the electromagnetic separator 2, and the eluted The reaction solution containing the magnetic particles is returned to the second feed port of the reactor 1 for refining treatment.

Preferably, the backflush is: a backflush mixed with nitrogen.

Specifically, a catalyst is added to the reaction kettle 1 for stirring, and the reaction solution containing the magnetic nanoparticles is refined; the catalyst added in the reaction kettle 1 undergoes a redox reaction with the reaction solution containing the magnetic nanoparticles. Preferably, under normal pressure conditions, the stirring speed of the reaction kettle 1 is: 500-2000 rpm, the stirring time is: 30-360 min, and the temperature range is: room temperature to 80 °C.

S4. The refined reaction solution containing magnetic nanoparticles is sent to the tubular centrifuge 3, and the magnetic nanoparticles that do not meet the specifications are removed by centrifugation, and discharged from the liquid outlet of the tubular centrifuge.

Specifically, the size of the removed magnetic nanoparticles can be adjusted according to the actual needs of the user; preferably, the magnetic nanoparticles larger than 12 nm are removed; the rotating speed of the centrifuge is 4000-6000 rpm, and the magnetic nanoparticles larger than 12 nm are removed.

S5, the tubular centrifuge 3 sends the remaining magnetic nanoparticle reaction liquid that meets the particle size requirements to the first membrane separator 4, and removes the small-molecule magnetic nanoparticles that do not meet the specifications; Drain port for discharge.

Specifically, the size of the removed molecular weight can be adapted according to the user's settings. Preferably, the reaction solution containing magnetic nanoparticles with a size of less than 12 nm is passed into the first membrane separator 4 to remove magnetic nanoparticles with a molecular weight of less than 3500.

S6. The first membrane separator 4 returns the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to the reaction kettle 1 for coating with polymer materials.

Specifically, the remaining reaction solution containing magnetic nanoparticles with a molecular weight greater than 3500 (particle size is 1 nm-12 nm) is returned to the reactor 1, and a polymer material is added to the reactor 1 to coat the magnetic nanoparticles with the polymer material.

Preferably, under normal pressure conditions, the stirring speed of the reactor 1 is 200-1000 rpm, the stirring time is 30min to 360min, and the temperature range is from room temperature to 80°C; the polymer material added in the reactor 1 is a hydrophilic polymer. Excipients, stabilizers.

The purpose of encapsulating the magnetic nanoparticles is to increase the hydrophilicity and stability, reduce their non-specific adsorption in the human body, and reduce the toxicity of nano-biological materials.

Therefore, the magnetic nanoparticles encapsulated by the organic polymer material can reduce the repulsion and damage to the human body during use.

S7, the reaction kettle 1 sends the coated magnetic nanoparticle reaction solution to the second membrane separator 5 to remove the magnetic nanoparticles that do not meet the molecular weight requirements, and discharges from the liquid outlet of the second membrane separator 5.

Specifically, magnetic nanoparticles with a molecular weight greater than 10,000 are removed; impurities with a molecular weight greater than 10,000 are removed; and since the molecular weight of the nano-biological material becomes larger after the polymer is wrapped, the purpose is also to remove the unwrapped and molecular weight greater than 10,000. biomaterials.

S8. The second membrane separator 5 sends the remaining magnetic nanoparticle reaction solution that meets the molecular weight requirements to the vacuum distillation column 6 for concentration. After reaching the specified concentration, the production is completed, and the nanobiomedical material is finally obtained.

Preferably, the temperature range of the vacuum distillation column 6 is 60-70°C.

The production process of the nano biomedical material of the present invention can not only achieve precise and refined treatment, so that the produced nano biomedical material is non-toxic and improves the safety of users; the present invention can also effectively improve the The quality pass rate of the produced materials.

The above descriptions are only preferred embodiments of the present invention, which are merely illustrative rather than limiting for the present invention. Those skilled in the art understand that many changes, modifications and even equivalents can be made within the spirit and scope defined by the claims of the present invention, but all fall within the protection scope of the present invention.

Claims (9)

1. A production system of nano biomedical materials is characterized by comprising a reaction kettle (1), an electromagnetic separator (2), a tubular centrifuge (3), a first membrane separator (4), a second membrane separator (5) and a reduced pressure distillation tower (6);

the reaction kettle (1) is used for preparing magnetic particles, finely processing the magnetic particles and organically coating the finely processed magnetic particles;

the electromagnetic separator (2): used for separating the magnetic particles prepared in the reaction kettle (1) from the reaction liquid;

the tube centrifuge (3): the magnetic particle removing device is used for removing magnetic particles which do not meet the requirement of particle size after fine processing;

the first membrane separator (4): the magnetic particle removing device is used for removing magnetic particles which do not meet the requirement of molecular weight after fine processing;

the second membrane separator (5): used for removing the magnetic particles which do not meet the molecular weight requirement after organic coating;

the reduced pressure distillation column (6): the magnetic particle concentrator is used for concentrating magnetic particles meeting the particle size requirement and the molecular weight requirement after organic coating;

a liquid outlet of the reaction kettle (1) is respectively connected with a liquid inlet of the electromagnetic separator (2), a liquid inlet of the tubular centrifuge (3) and a liquid inlet of the second membrane separator (5); a liquid outlet of the electromagnetic separator (2) is connected with a second liquid inlet of the reaction kettle (1);

a liquid outlet of the tubular centrifuge (3) is connected with a liquid inlet of the first membrane separator (4), and a liquid outlet of the first membrane separator (4) is connected with any liquid inlet of the reaction kettle (1); the liquid outlet of the second membrane separator (5) is connected with the liquid inlet of the reduced pressure distillation tower (6).

2. The system for producing nano biomedical materials according to claim 1, wherein said system is characterized in that

The top of the electromagnetic separator (2) is also provided with a spraying device for washing the magnetic particles.

3. The system for producing nano biomedical materials according to claim 2, wherein the electromagnetic separator (2) further comprises means for adjusting the electromagnetic intensity.

4. The process for producing a nano biomedical material production system according to any one of claims 1 to 3, comprising the steps of:

s1, adding raw materials to be prepared into a reaction kettle (1) according to a certain proportion, and reacting in the reaction kettle (1) to prepare a reaction solution containing nano-scale magnetic particles;

s2, the reaction kettle (1) sends the prepared reaction liquid containing the nano-scale magnetic particles to an electromagnetic separator (2), the magnetic separation of the liquid and the nano-scale magnetic particles is carried out, and the separated liquid is discharged; the electromagnetic separator (2) continuously washes all the nanometer magnetic particles by washing liquid;

s3, after the washed washing liquid is discharged completely by the electromagnetic separator (2), stopping electrifying and introducing a backflushing liquid, eluting the nanoscale magnetic particles from the wall of the electromagnetic separator (2), returning the reaction liquid containing the magnetic particles after elution to the reaction kettle (1), and performing refinement treatment;

s4, sending the reaction liquid containing the magnetic nanoparticles after the fine treatment to a tubular centrifuge (3), and centrifuging to remove the magnetic nanoparticles which do not meet the size specification of the particle size;

s5, the tubular centrifuge (3) sends the residual magnetic nanoparticle reaction liquid meeting the particle size requirement to a first membrane separator (4) to remove the magnetic nanoparticles not meeting the molecular weight requirement;

s6, returning the residual magnetic nanoparticle reaction solution meeting the molecular weight requirement to the reaction kettle (1) by the first membrane separator (4) for coating with a high polymer material;

s7, the reaction kettle (1) sends the coated magnetic nano-particle reaction liquid to a second membrane separator (5) to remove the magnetic nano-particles which do not meet the molecular weight requirement;

s8, the second membrane separator (5) sends the residual magnetic nanoparticle reaction liquid meeting the molecular weight requirement to a reduced pressure distillation tower (6) for concentration, and the production is finished after the concentration reaches the designated concentration.

5. The production process as claimed in claim 4, wherein the stirring speed of the reaction vessel (1) in the steps S1 and S3 is: 500-: 30-360min, and the temperature range is as follows: from room temperature to 80 ℃.

6. The production process as claimed in claim 4, wherein the magnetic field strength in the electromagnetic separator (2) in the step S2 is in the range of: 2000 + 10000 gauss.

7. The production process as claimed in claim 4, wherein the rotation speed range of the tube centrifuge (3) in the step S4 is: 4000-6000 rpm.

8. The production process as claimed in claim 4, wherein the stirring speed of the reaction tank (1) in the step S6 is: 200-1000 rpm, stirring time 30-360min, temperature range: from room temperature to 80 ℃.

9. The production process as claimed in claim 4, wherein the temperature range of the vacuum distillation column (6) in the step S8 is: 60-70 ℃.

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