CN109382051B - A kind of production system of nanometer biomedical material and its production process - Google Patents

A kind of production system of nanometer biomedical material and its production process Download PDF

Info

Publication number
CN109382051B
CN109382051B CN201811365459.6A CN201811365459A CN109382051B CN 109382051 B CN109382051 B CN 109382051B CN 201811365459 A CN201811365459 A CN 201811365459A CN 109382051 B CN109382051 B CN 109382051B
Authority
CN
China
Prior art keywords
liquid
magnetic
magnetic particles
separator
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201811365459.6A
Other languages
Chinese (zh)
Other versions
CN109382051A (en
Inventor
王爱芳
李全
谷新春
王宇光
张志�
郭仁君
吴卓娅
林建英
吴爱国
陈天翔
马雪华
任文智
李升大
孟启贵
卫维剑
李子英
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEDIN NINGBO ENGINEERING CO LTD
Ningbo Institute of Material Technology and Engineering of CAS
Original Assignee
SEDIN NINGBO ENGINEERING CO LTD
Ningbo Institute of Material Technology and Engineering of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEDIN NINGBO ENGINEERING CO LTD, Ningbo Institute of Material Technology and Engineering of CAS filed Critical SEDIN NINGBO ENGINEERING CO LTD
Publication of CN109382051A publication Critical patent/CN109382051A/en
Application granted granted Critical
Publication of CN109382051B publication Critical patent/CN109382051B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053Details of the reactor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10Vacuum distillation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58Multistep processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention discloses a production system and a production process of a nano biomedical material, belonging to the technical field of medical material production. The production system and the production process of the nano biomedical material not only can produce the nano biomedical material safely and reliably, but also can effectively meet the requirement that the corresponding nano biomedical material cannot be produced at home at present.

Description

一种纳米生物医用材料的生产系统及其生产工艺A kind of production system of nanometer biomedical material and its production process

技术领域technical field

本发明涉及医用材料生产技术领域,具体涉及一种纳米生物医用材料的生产系统及其生产工艺。The invention relates to the technical field of medical material production, in particular to a production system and a production process of nanometer biomedical material.

背景技术Background technique

目前,纳米生物医用材料在辅助生物检测诊断上有着非常显著的效果。但基于纳米生物医用材料目前市场上没有相关的工业化的生产系统和其生产工艺,因此,市场上急需一种能够生产出纳米生物医用材料的生产系统及其生产工艺。At present, nano-biomedical materials have a very significant effect in assisting biological detection and diagnosis. However, based on nano-biomedical materials, there is currently no relevant industrialized production system and production process on the market. Therefore, there is an urgent need for a production system and production process that can produce nano-biomedical materials.

鉴于上述缺陷,本发明创作者经过长时间的研究和实践终于获得了本发明。In view of the above-mentioned defects, the creator of the present invention finally obtained the present invention after a long period of research and practice.

发明内容SUMMARY OF THE INVENTION

有鉴于此,本发明旨在提出一种纳米生物医用材料的生产系统及其生产工艺,能够解决市场上没有一种生产出纳米生物医用材料的生产系统及其生产工艺的问题。In view of this, the present invention aims to propose a production system and production process of nano-biomedical materials, which can solve the problem that there is no production system and production process for producing nano-biomedical materials on the market.

为达到上述目的,本发明的技术方案是这样实现的:In order to achieve the above object, the technical scheme of the present invention is achieved in this way:

一种纳米生物医用材料的生产系统,包括反应釜、电磁分离器、管式离心机、第一膜分离器、第二膜分离器、减压蒸馏塔;A production system for nano-biomedical materials, comprising a reactor, an electromagnetic separator, a tubular centrifuge, a first membrane separator, a second membrane separator, and a vacuum distillation column;

所述反应釜,用于制备磁性颗粒以及对磁性颗粒进行精细化处理和对精细化处理后的磁性颗粒进行有机包覆;The reaction kettle is used for preparing magnetic particles, fine-processing the magnetic particles, and organically coating the magnetic particles after the fine-processing;

所述电磁分离器用于将反应釜中制备出的磁性颗粒从反应液中分离;The electromagnetic separator is used to separate the magnetic particles prepared in the reaction kettle from the reaction liquid;

所述管式离心机:用于去除精细化处理后不符合粒径要求的磁性颗粒;The tubular centrifuge: used to remove magnetic particles that do not meet the particle size requirements after fine treatment;

所述第一膜分离器:用于去除精细化处理后不符合分子量要求的磁性颗粒;The first membrane separator: used to remove magnetic particles that do not meet the molecular weight requirements after refining;

所述第二膜分离器:用于去除有机包覆后不符合分子量要求的磁性颗粒;The second membrane separator: used to remove magnetic particles that do not meet the molecular weight requirements after organic coating;

所述减压蒸馏塔:用于将符合粒径要求和有机包裹后分子量要求的磁性粒子进行浓缩。The vacuum distillation column: used to concentrate the magnetic particles that meet the particle size requirements and the molecular weight requirements after organic encapsulation.

进一步的,所述反应釜的第一出液口分别与所述电磁分离器的进液口、管式离心机的进液口、第二膜分离器的进液口连接;所述电磁分离器的出液口连接所述反应釜的第二进液口连接;Further, the first liquid outlet of the reaction kettle is respectively connected with the liquid inlet of the electromagnetic separator, the liquid inlet of the tubular centrifuge, and the liquid inlet of the second membrane separator; the electromagnetic separator The liquid outlet is connected to the second liquid inlet of the reactor;

所述管式离心机的出液口连接所述第一膜分离器的进液口,所述第一膜分离器的出液口连接所述反应釜的任一进液口;所述第二膜分离器的出液口与所述减压蒸馏塔的进液口相连接。The liquid outlet of the tubular centrifuge is connected to the liquid inlet of the first membrane separator, and the liquid outlet of the first membrane separator is connected to any liquid inlet of the reactor; the second The liquid outlet of the membrane separator is connected with the liquid inlet of the vacuum distillation column.

进一步的,所述电磁分离器的顶部还设有一喷淋装置,用于对磁性颗粒进行洗涤。Further, the top of the electromagnetic separator is also provided with a spray device for washing the magnetic particles.

进一步的,所述电磁分离器还包括可调节电磁强度装置。Further, the electromagnetic separator also includes an adjustable electromagnetic intensity device.

利用上述任一所述的纳米生物医用材料的生产系统的生产工艺,包括以下步骤:Utilize the production process of the production system of any of the above-mentioned nano biomedical materials, comprising the following steps:

S1、把需要配置的原料按照一定的比例添加到反应釜,通过所述反应釜反应,制备得到含有纳米级磁性颗粒的反应液;S1, the raw materials that need to be configured are added to the reaction kettle according to a certain proportion, and the reaction solution containing nano-scale magnetic particles is prepared by the reaction of the reaction kettle;

S2、所述反应釜将制备得到含有纳米级磁性颗粒的反应液送至电磁分离器,进行液体与纳米级磁性颗粒的磁性分离,将分离后的液体排出后;所述电磁分离器继续通过洗涤液对所有纳米级磁性颗粒进行洗涤;S2, the reaction kettle will prepare the reaction liquid containing nano-scale magnetic particles and send it to the electromagnetic separator, carry out the magnetic separation of the liquid and the nano-scale magnetic particles, and discharge the separated liquid; the electromagnetic separator continues to wash liquid to wash all nano-scale magnetic particles;

S3、所述电磁分离器将洗涤后的洗涤液排放干净后,停止通电并通入反冲液,将纳米级磁性颗粒从所述电磁分离器的器壁上洗脱下来,将洗脱后含有磁性颗粒反应液返回至所述反应釜,精细化处理;S3. After the electromagnetic separator discharges the washed washing liquid, the electricity is stopped and the backflushing liquid is passed into it to elute the nano-scale magnetic particles from the wall of the electromagnetic separator. The magnetic particle reaction liquid is returned to the reaction kettle for fine processing;

S4、将精细化处理后的含有磁性纳米颗粒的反应液送至管式离心机,离心去除不符合粒径规格大小的磁性纳米颗粒;S4. The refined reaction solution containing magnetic nanoparticles is sent to a tubular centrifuge, and the magnetic nanoparticles that do not meet the particle size specifications are removed by centrifugation;

S5、所述管式离心机将剩余符合粒径要求的磁性纳米颗粒反应液送至第一膜分离器,脱除不符合分子量要求的磁性纳米颗粒;S5, the tubular centrifuge sends the remaining magnetic nanoparticle reaction liquid meeting the particle size requirements to the first membrane separator to remove the magnetic nanoparticles that do not meet the molecular weight requirements;

S6、所述第一膜分离器将剩余的符合分子量要求的磁性纳米颗粒反应液返回至所述反应釜中,高分子材料包覆;S6, the first membrane separator returns the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to the reaction kettle, and is covered with a polymer material;

S7、所述反应釜把包覆后的磁性纳米颗粒反应液送至第二膜分离器,脱除不符合分子量要求的磁性纳米颗粒;S7, the reaction kettle sends the coated magnetic nanoparticle reaction solution to the second membrane separator to remove the magnetic nanoparticles that do not meet the molecular weight requirements;

S8、所述第二膜分离器将剩余的符合分子量要求的磁性纳米颗粒反应液送至减压蒸馏塔,进行浓缩,达到指定浓度后,完成生产。S8. The second membrane separator sends the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to a vacuum distillation tower for concentration, and after reaching a specified concentration, the production is completed.

进一步的,所述步骤S1、S3中的反应釜的搅拌速度为:500-2000 rpm,搅拌时间为:30-360min,温度范围为:室温到80℃。Further, the stirring speed of the reaction kettle in the steps S1 and S3 is: 500-2000 rpm, the stirring time is: 30-360 min, and the temperature range is: room temperature to 80°C.

进一步的,所述步骤S2中的电磁分离器中的磁场强度范围为:2000-10000高斯。Further, the intensity range of the magnetic field in the electromagnetic separator in the step S2 is: 2000-10000 Gauss.

进一步的,所述步骤S4中的管式离心机的转速范围为:4000-6000rpm。Further, the rotational speed range of the tubular centrifuge in the step S4 is 4000-6000 rpm.

进一步的,所述步骤S6中的反应釜的搅拌速度为:200-1000 rpm,搅拌时间30-360min,温度范围为:室温到80℃。Further, the stirring speed of the reaction kettle in the step S6 is: 200-1000 rpm, the stirring time is 30-360 min, and the temperature range is: room temperature to 80°C.

进一步的,所述步骤S8中所述减压蒸馏塔的温度范围为:60-70℃。Further, the temperature range of the vacuum distillation column in the step S8 is: 60-70°C.

与现有技术比较本发明的有益效果在于:1,本发明所述得纳米生物医用材料的生产系统及其生产工艺不仅生产出的纳米生物医用材料安全、可靠,还能够有效的解决现在国内无法生产相应的纳米医用生物材料的需求。2,本发明所述的纳米生物医用材料的生产系统简单,易操控;能够有效的降低企业或用户的成本。3,本发明所述的纳米生物医用材料的生产系统及其生产工艺不仅能够准确的做到精细化的处理,还能够有效的提高了生产出材料的质量合格率。Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The production system for obtaining nano-biomedical materials according to the present invention and the production process thereof not only produce safe and reliable nano-biomedical materials, but also can effectively solve the problems that cannot be achieved in China. The demand for the production of corresponding nano-medical biomaterials. 2. The production system of the nano-biomedical material of the present invention is simple and easy to control; it can effectively reduce the cost of enterprises or users. 3. The nano biomedical material production system and its production process according to the present invention can not only achieve precise and refined processing, but also can effectively improve the quality qualification rate of the produced materials.

附图说明Description of drawings

为了更清楚地说明本发明各实施例中的技术方案,下面将对实施例描述中所需要使用的附图作简单地介绍。In order to illustrate the technical solutions in the various embodiments of the present invention more clearly, the following briefly introduces the accompanying drawings used in the description of the embodiments.

图1是本发明实施例的生产系统示意图;Fig. 1 is the production system schematic diagram of the embodiment of the present invention;

图中数字表示:The numbers in the figure represent:

1.反应釜 2.电磁分离器 3.管式离心机 4.第一膜分离器 5.第二膜分离器 6.减压蒸馏塔1. Reactor 2. Electromagnetic Separator 3. Tube Centrifuge 4. First Membrane Separator 5. Second Membrane Separator 6. Vacuum Distillation Column

具体实施方式Detailed ways

以下结合附图,对本发明上述的和另外的技术特征和优点作更详细的说明。The above and other technical features and advantages of the present invention will be described in more detail below with reference to the accompanying drawings.

实施例1Example 1

如图1所示,一种纳米生物医用材料的生产系统,包括反应釜1、电磁分离器2、管式离心机3、第一膜分离器4、第二膜分离器5、减压蒸馏塔6。As shown in Figure 1, a production system of nano-biomedical materials includes a reactor 1, an electromagnetic separator 2, a tubular centrifuge 3, a first membrane separator 4, a second membrane separator 5, and a vacuum distillation column 6.

反应釜1,用于制备磁性颗粒(磁性粒子)以及对磁性颗粒进行精细化处理和对精细化处理后的磁性颗粒进行有机包覆;Reactor 1, used for preparing magnetic particles (magnetic particles), refining the magnetic particles and organically coating the refined magnetic particles;

电磁分离器2:用于将反应釜1中制备出的磁性颗粒从反应液中分离;Electromagnetic separator 2: used to separate the magnetic particles prepared in the reactor 1 from the reaction solution;

管式离心机3:用于去除精细化处理后不符合粒径要求的磁性颗粒;主要用于去除大于12nm的磁性纳米颗粒物。Tubular centrifuge 3: It is used to remove magnetic particles that do not meet the particle size requirements after refining treatment; it is mainly used to remove magnetic nanoparticles larger than 12 nm.

第一膜分离器4:用于去除精细化处理后不符合分子量要求的磁性颗粒;主要进行脱除分子量小于3500的磁性纳米颗粒。The first membrane separator 4: used to remove magnetic particles that do not meet the molecular weight requirements after refining treatment; mainly to remove magnetic nanoparticles with a molecular weight of less than 3500.

第二膜分离器5:用于去除有机包覆后不符合分子量要求的磁性颗粒;主要进行脱除分子量大于10000的磁性纳米颗粒。Second membrane separator 5: used to remove magnetic particles that do not meet the molecular weight requirements after organic coating; mainly remove magnetic nanoparticles with molecular weight greater than 10,000.

减压蒸馏塔6:用于将符合粒径要求和有机包裹后分子量要求的磁性粒子进行浓缩。Vacuum distillation column 6: used to concentrate the magnetic particles that meet the particle size requirements and the molecular weight requirements after organic encapsulation.

反应釜1的出液口分别与电磁分离器2的进液口、管式离心机3的进液口、第二膜分离器5的进液口连接,但三者的进液口并不同时进液;当电磁分离器2的进液口或管式离心机3的进液口或第二膜分离器5的进液口打开时,其余两个进液口处于关闭状态。The liquid outlet of the reactor 1 is respectively connected with the liquid inlet of the electromagnetic separator 2, the liquid inlet of the tubular centrifuge 3, and the liquid inlet of the second membrane separator 5, but the liquid inlets of the three are not at the same time. Liquid inlet; when the liquid inlet of the electromagnetic separator 2 or the liquid inlet of the tubular centrifuge 3 or the liquid inlet of the second membrane separator 5 is opened, the other two liquid inlets are closed.

电磁分离器2的出液口连接反应釜1的第二进液口连接;电磁分离器2 的进液口和出液口的位置可根据实际需要进行自设置;可上进下出,也可下进上出。The liquid outlet of the electromagnetic separator 2 is connected to the second liquid inlet of the reactor 1; the positions of the liquid inlet and the liquid outlet of the electromagnetic separator 2 can be set according to actual needs; In and out.

管式离心机3的出液口连接第一膜分离器4的进液口,第一膜分离器4的出液口连接反应釜1的任一进液口。The liquid outlet of the tubular centrifuge 3 is connected to the liquid inlet of the first membrane separator 4 , and the liquid outlet of the first membrane separator 4 is connected to any liquid inlet of the reactor 1 .

第二膜分离器5的出液口与减压蒸馏塔6的进液口相连接。The liquid outlet of the second membrane separator 5 is connected to the liquid inlet of the vacuum distillation column 6 .

上述的反应釜1、电磁分离器2、管式离心机3、第一膜分离器4、第二膜分离器5、减压蒸馏塔6均设有排液口,排液口的位置根据实际需要进行自行调整均可。The above-mentioned reaction kettle 1, electromagnetic separator 2, tubular centrifuge 3, first membrane separator 4, second membrane separator 5, and vacuum distillation tower 6 are all provided with a drain outlet, and the location of the drain outlet is based on the actual situation. You may need to adjust it yourself.

本发明所述得纳米生物医用材料的生产系统生产出的纳米生物材料不仅安全、可靠,还能够有效的解决现在国内无法生产相应的纳米医用生物材料的需求。The nano-biomaterials produced by the production system for obtaining nano-biomedical materials of the present invention are not only safe and reliable, but also can effectively meet the current domestic demand that cannot produce corresponding nano-medical biomaterials.

实施例2Example 2

电磁分离器2的顶部还设有一喷淋装置,用于对磁性颗粒进行洗涤;所述喷淋装置能够准确的将所有磁性颗粒全面的进行洗涤,还能够节省洗涤时所用的洗涤液,有效的降低企业或用户的成本。The top of the electromagnetic separator 2 is also provided with a spray device for washing the magnetic particles; the spray device can accurately and comprehensively wash all the magnetic particles, and can also save the washing liquid used in washing, effectively Reduce costs for businesses or users.

实施例3Example 3

电磁分离器2还包括一可调节电磁强度装置。用户按照实际需要对电磁强度进行自行调节。可调节的电磁强度有效的满足了用户对于自行设置电磁强度的需要,使整个系统使用起来方便,快捷。The electromagnetic separator 2 also includes an adjustable electromagnetic strength device. Users can adjust the electromagnetic intensity according to actual needs. The adjustable electromagnetic intensity effectively meets the needs of users to set the electromagnetic intensity by themselves, making the whole system convenient and fast to use.

实施例4Example 4

利用上述实施例中的一种纳米生物医用材料的生产系统的工艺,包括以下步骤:Utilize the technology of a kind of nano biomedical material production system in the above-mentioned embodiment, comprises the following steps:

S1、把需要配置的原料按照一定的比例添加到反应釜1,通过反应釜1反应,制备得到含有纳米级磁性颗粒的反应液;S1, adding the raw materials to be configured to the reaction kettle 1 according to a certain proportion, and reacting in the reaction kettle 1 to prepare a reaction solution containing nano-scale magnetic particles;

具体的,添加原料后,在常压的状态下,反应釜1进行搅拌。Specifically, after adding the raw materials, the reaction vessel 1 is stirred under normal pressure.

较佳的,反应釜1的搅拌速度为:500-2000 rpm(转/分钟),搅拌时间为:30-360min,温度范围为:室温到80℃。Preferably, the stirring speed of the reaction kettle 1 is: 500-2000 rpm (revolution/min), the stirring time is: 30-360 min, and the temperature range is: room temperature to 80°C.

S2、反应釜1将制备得到含有纳米级磁性颗粒的反应液送至电磁分离器2的进料口,进行液体与纳米级磁性颗粒的磁性分离,将分离后的液体自排液口排出后;电磁分离器2继续对所有纳米级磁性颗粒通过洗涤液进行洗涤;S2, the reaction kettle 1 sends the prepared reaction solution containing the nano-scale magnetic particles to the feed port of the electromagnetic separator 2, carries out the magnetic separation of the liquid and the nano-scale magnetic particles, and discharges the separated liquid from the liquid outlet; Electromagnetic separator 2 continues to wash all nano-scale magnetic particles by washing liquid;

具体的,反应釜1制备得到含有纳米级磁性颗粒的反应液进入电磁分离器2后,对电磁分离器2进行通电,含有纳米级磁性颗粒的反应液经电磁分离器2分离,使纳米磁性颗粒吸附在电磁分离器2的内壁上,剩余反应液从电磁分离器2的排液口排出。较佳的,电磁分离器2设置磁场强度为:2000高斯到10000高斯。Specifically, after the reaction liquid containing nano-scale magnetic particles prepared in the reaction kettle 1 enters the electromagnetic separator 2, the electromagnetic separator 2 is energized, and the reaction liquid containing the nano-scale magnetic particles is separated by the electromagnetic separator 2, so that the nano-magnetic particles are separated. Adsorbed on the inner wall of the electromagnetic separator 2 , the remaining reaction liquid is discharged from the liquid discharge port of the electromagnetic separator 2 . Preferably, the magnetic field strength of the electromagnetic separator 2 is set to: 2000 Gauss to 10000 Gauss.

反应液全部通过电磁分离器2,磁性颗粒被全部吸附后,开通电磁分离器顶部的喷淋装置,对磁性颗粒进行洗涤,直至排出液PH值达到7为止。All the reaction liquid passes through the electromagnetic separator 2. After all the magnetic particles are adsorbed, the spray device on the top of the electromagnetic separator is turned on to wash the magnetic particles until the pH value of the discharged liquid reaches 7.

S3、将电磁分离器2内的洗涤液排放干净后,电磁分离器2停止通电并通入反冲液,将纳米级磁性颗粒从电磁分离器2的器壁上洗脱下来,将洗脱后含有磁性颗粒反应液返回至反应釜1的第二进料口,进行精细化处理。S3. After the washing liquid in the electromagnetic separator 2 is completely drained, the electromagnetic separator 2 is turned off and the backflush is passed into it, so that the nano-scale magnetic particles are eluted from the wall of the electromagnetic separator 2, and the eluted The reaction solution containing the magnetic particles is returned to the second feed port of the reactor 1 for refining treatment.

较佳的,反冲液为:混有氮气的反冲液。Preferably, the backflush is: a backflush mixed with nitrogen.

具体的,在反应釜1中再加入催化剂进行搅拌,对含有磁性纳米颗粒的反应液进行精细化处理;在反应釜1中添加的催化剂,与含有磁性纳米颗粒的反应液进行氧化还原反应。较佳的,常压条件下,反应釜1搅拌速度为:500-2000 rpm,搅拌时间为:30-360min,温度范围为:室温到80℃。Specifically, a catalyst is added to the reaction kettle 1 for stirring, and the reaction solution containing the magnetic nanoparticles is refined; the catalyst added in the reaction kettle 1 undergoes a redox reaction with the reaction solution containing the magnetic nanoparticles. Preferably, under normal pressure conditions, the stirring speed of the reaction kettle 1 is: 500-2000 rpm, the stirring time is: 30-360 min, and the temperature range is: room temperature to 80 °C.

S4、将精细化处理后的含有磁性纳米颗粒的反应液送至管式离心机3,离心去除不符合规格大小的磁性纳米颗粒,并自管式离心机排液口排出。S4. The refined reaction solution containing magnetic nanoparticles is sent to the tubular centrifuge 3, and the magnetic nanoparticles that do not meet the specifications are removed by centrifugation, and discharged from the liquid outlet of the tubular centrifuge.

具体的,去除磁性纳米颗粒的大小,可根据用户的实际需要进行自行调整;较佳的,将大于12nm的磁性纳米颗粒去除;离心机的转速在4000-6000rpm,去除大于12nm的磁性纳米颗粒物。Specifically, the size of the removed magnetic nanoparticles can be adjusted according to the actual needs of the user; preferably, the magnetic nanoparticles larger than 12 nm are removed; the rotating speed of the centrifuge is 4000-6000 rpm, and the magnetic nanoparticles larger than 12 nm are removed.

S5、管式离心机3将剩余符合粒径要求的磁性纳米颗粒反应液送至第一膜分离器4,进行脱除不符合规格的小分子磁性纳米颗粒;并自第一膜分离器4的排液口进行排出。S5, the tubular centrifuge 3 sends the remaining magnetic nanoparticle reaction liquid that meets the particle size requirements to the first membrane separator 4, and removes the small-molecule magnetic nanoparticles that do not meet the specifications; Drain port for discharge.

具体的,对于脱除分子量的大小,可根据用户的设置进行适应的改变。较佳的,将含有小于12nm的磁性纳米颗粒物反应液通入第一膜分离器4,进行脱除分子量小于3500的磁性纳米颗粒。Specifically, the size of the removed molecular weight can be adapted according to the user's settings. Preferably, the reaction solution containing magnetic nanoparticles with a size of less than 12 nm is passed into the first membrane separator 4 to remove magnetic nanoparticles with a molecular weight of less than 3500.

S6、第一膜分离器4将剩余的符合分子量要求的磁性纳米颗粒反应液返回至反应釜1中,进行高分子材料包覆。S6. The first membrane separator 4 returns the remaining magnetic nanoparticle reaction liquid that meets the molecular weight requirements to the reaction kettle 1 for coating with polymer materials.

具体的,剩余含有分子量大于3500的磁性纳米颗粒反应液(粒径为1nm-12nm)返回反应釜1,在反应釜1中加入高分子材料对磁性纳米颗粒进行高分子材料包覆。Specifically, the remaining reaction solution containing magnetic nanoparticles with a molecular weight greater than 3500 (particle size is 1 nm-12 nm) is returned to the reactor 1, and a polymer material is added to the reactor 1 to coat the magnetic nanoparticles with the polymer material.

较佳的,常压条件下,反应釜1的搅拌速度为200-1000 rpm,搅拌时间30min到360min,温度范围为室温到80℃;反应釜1中加入的高分子材料为亲水性高分子辅料、稳定剂。Preferably, under normal pressure conditions, the stirring speed of the reactor 1 is 200-1000 rpm, the stirring time is 30min to 360min, and the temperature range is from room temperature to 80°C; the polymer material added in the reactor 1 is a hydrophilic polymer. Excipients, stabilizers.

对磁性纳米颗粒进行包裹高分子材料目的在于增加亲水性、稳定性,降低其在人体内应用时的非特异性吸附,以及降低纳米生物材料毒性。The purpose of encapsulating the magnetic nanoparticles is to increase the hydrophilicity and stability, reduce their non-specific adsorption in the human body, and reduce the toxicity of nano-biological materials.

故,包裹有机高分子材料后的磁性纳米颗粒,使用时能够减少对人体的排斥和伤害。Therefore, the magnetic nanoparticles encapsulated by the organic polymer material can reduce the repulsion and damage to the human body during use.

S7、反应釜1把包覆后的磁性纳米颗粒反应液送至第二膜分离器5,进行脱除不符合分子量要求的磁性纳米颗粒,并自第二膜分离器5的排液口排出。S7, the reaction kettle 1 sends the coated magnetic nanoparticle reaction solution to the second membrane separator 5 to remove the magnetic nanoparticles that do not meet the molecular weight requirements, and discharges from the liquid outlet of the second membrane separator 5.

具体的,进行脱除分子量大于10000的磁性纳米颗粒;去除的是大于10000分子量的杂质;而且由于高分子包裹后,纳米生物材料分子量变大,目的也在于去除未包裹且分子量大于10000高分子的生物材料。Specifically, magnetic nanoparticles with a molecular weight greater than 10,000 are removed; impurities with a molecular weight greater than 10,000 are removed; and since the molecular weight of the nano-biological material becomes larger after the polymer is wrapped, the purpose is also to remove the unwrapped and molecular weight greater than 10,000. biomaterials.

S8、第二膜分离器5将剩余的符合分子量要求的磁性纳米颗粒反应液送至减压蒸馏塔6,进行浓缩,达到指定浓度后,完成生产,最终得到纳米生物医用材料。S8. The second membrane separator 5 sends the remaining magnetic nanoparticle reaction solution that meets the molecular weight requirements to the vacuum distillation column 6 for concentration. After reaching the specified concentration, the production is completed, and the nanobiomedical material is finally obtained.

较佳的,减压蒸馏塔6的温度范围为:60-70℃。Preferably, the temperature range of the vacuum distillation column 6 is 60-70°C.

本发明所述的纳米生物医用材料的生产工艺不仅能够准确的做到精细化的处理,使其生产出的纳米生物医用材料无毒,提高使用者的安全性;本发明还能够有效的提高了生产出材料的质量合格率。The production process of the nano biomedical material of the present invention can not only achieve precise and refined treatment, so that the produced nano biomedical material is non-toxic and improves the safety of users; the present invention can also effectively improve the The quality pass rate of the produced materials.

以上所述仅为本发明的较佳实施例,对本发明而言仅仅是说明性的,而非限制性的。本专业技术人员理解,在本发明权利要求所限定的精神和范围内可对其进行许多改变,修改,甚至等效,但都将落入本发明的保护范围内。The above descriptions are only preferred embodiments of the present invention, which are merely illustrative rather than limiting for the present invention. Those skilled in the art understand that many changes, modifications and even equivalents can be made within the spirit and scope defined by the claims of the present invention, but all fall within the protection scope of the present invention.

Claims (9)

1. A production system of nano biomedical materials is characterized by comprising a reaction kettle (1), an electromagnetic separator (2), a tubular centrifuge (3), a first membrane separator (4), a second membrane separator (5) and a reduced pressure distillation tower (6);
the reaction kettle (1) is used for preparing magnetic particles, finely processing the magnetic particles and organically coating the finely processed magnetic particles;
the electromagnetic separator (2): used for separating the magnetic particles prepared in the reaction kettle (1) from the reaction liquid;
the tube centrifuge (3): the magnetic particle removing device is used for removing magnetic particles which do not meet the requirement of particle size after fine processing;
the first membrane separator (4): the magnetic particle removing device is used for removing magnetic particles which do not meet the requirement of molecular weight after fine processing;
the second membrane separator (5): used for removing the magnetic particles which do not meet the molecular weight requirement after organic coating;
the reduced pressure distillation column (6): the magnetic particle concentrator is used for concentrating magnetic particles meeting the particle size requirement and the molecular weight requirement after organic coating;
a liquid outlet of the reaction kettle (1) is respectively connected with a liquid inlet of the electromagnetic separator (2), a liquid inlet of the tubular centrifuge (3) and a liquid inlet of the second membrane separator (5); a liquid outlet of the electromagnetic separator (2) is connected with a second liquid inlet of the reaction kettle (1);
a liquid outlet of the tubular centrifuge (3) is connected with a liquid inlet of the first membrane separator (4), and a liquid outlet of the first membrane separator (4) is connected with any liquid inlet of the reaction kettle (1); the liquid outlet of the second membrane separator (5) is connected with the liquid inlet of the reduced pressure distillation tower (6).
2. The system for producing nano biomedical materials according to claim 1, wherein said system is characterized in that
The top of the electromagnetic separator (2) is also provided with a spraying device for washing the magnetic particles.
3. The system for producing nano biomedical materials according to claim 2, wherein the electromagnetic separator (2) further comprises means for adjusting the electromagnetic intensity.
4. The process for producing a nano biomedical material production system according to any one of claims 1 to 3, comprising the steps of:
s1, adding raw materials to be prepared into a reaction kettle (1) according to a certain proportion, and reacting in the reaction kettle (1) to prepare a reaction solution containing nano-scale magnetic particles;
s2, the reaction kettle (1) sends the prepared reaction liquid containing the nano-scale magnetic particles to an electromagnetic separator (2), the magnetic separation of the liquid and the nano-scale magnetic particles is carried out, and the separated liquid is discharged; the electromagnetic separator (2) continuously washes all the nanometer magnetic particles by washing liquid;
s3, after the washed washing liquid is discharged completely by the electromagnetic separator (2), stopping electrifying and introducing a backflushing liquid, eluting the nanoscale magnetic particles from the wall of the electromagnetic separator (2), returning the reaction liquid containing the magnetic particles after elution to the reaction kettle (1), and performing refinement treatment;
s4, sending the reaction liquid containing the magnetic nanoparticles after the fine treatment to a tubular centrifuge (3), and centrifuging to remove the magnetic nanoparticles which do not meet the size specification of the particle size;
s5, the tubular centrifuge (3) sends the residual magnetic nanoparticle reaction liquid meeting the particle size requirement to a first membrane separator (4) to remove the magnetic nanoparticles not meeting the molecular weight requirement;
s6, returning the residual magnetic nanoparticle reaction solution meeting the molecular weight requirement to the reaction kettle (1) by the first membrane separator (4) for coating with a high polymer material;
s7, the reaction kettle (1) sends the coated magnetic nano-particle reaction liquid to a second membrane separator (5) to remove the magnetic nano-particles which do not meet the molecular weight requirement;
s8, the second membrane separator (5) sends the residual magnetic nanoparticle reaction liquid meeting the molecular weight requirement to a reduced pressure distillation tower (6) for concentration, and the production is finished after the concentration reaches the designated concentration.
5. The production process as claimed in claim 4, wherein the stirring speed of the reaction vessel (1) in the steps S1 and S3 is: 500-: 30-360min, and the temperature range is as follows: from room temperature to 80 ℃.
6. The production process as claimed in claim 4, wherein the magnetic field strength in the electromagnetic separator (2) in the step S2 is in the range of: 2000 + 10000 gauss.
7. The production process as claimed in claim 4, wherein the rotation speed range of the tube centrifuge (3) in the step S4 is: 4000-6000 rpm.
8. The production process as claimed in claim 4, wherein the stirring speed of the reaction tank (1) in the step S6 is: 200-1000 rpm, stirring time 30-360min, temperature range: from room temperature to 80 ℃.
9. The production process as claimed in claim 4, wherein the temperature range of the vacuum distillation column (6) in the step S8 is: 60-70 ℃.
CN201811365459.6A 2018-11-13 2018-11-16 A kind of production system of nanometer biomedical material and its production process Active CN109382051B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811347786 2018-11-13
CN2018113477869 2018-11-13

Publications (2)

Publication Number Publication Date
CN109382051A CN109382051A (en) 2019-02-26
CN109382051B true CN109382051B (en) 2020-12-18

Family

ID=65429593

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811365459.6A Active CN109382051B (en) 2018-11-13 2018-11-16 A kind of production system of nanometer biomedical material and its production process

Country Status (1)

Country Link
CN (1) CN109382051B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355319A (en) * 2001-12-07 2002-06-26 清华大学 Process for separating nucleic acid from biological particles by solid-phase carrier
CN101445277A (en) * 2008-11-14 2009-06-03 东北大学 Nano-crystalline Fe*O* particles with high absorption capacity and preparation method thereof
CN101612541A (en) * 2009-07-17 2009-12-30 江南大学 Preparation and application of polyacrylic acid-coated ferroferric oxide magnetic nanoparticles
JP2013146717A (en) * 2012-01-23 2013-08-01 Toshiba Corp Water treatment method and water treatment apparatus
US9121083B2 (en) * 2011-03-15 2015-09-01 Kabushiki Kaisha Toshiba Copper recovery apparatus and copper recovery method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4805201B2 (en) * 2007-03-22 2011-11-02 月島環境エンジニアリング株式会社 Method and apparatus for separation of target substance using membrane separation
IL184941A0 (en) * 2007-07-31 2008-12-29 Slavin Vladimir Method and device for producing biomass of photosynthesizing microorganisms mainly halobacteria halobacterium as well as biomass of the said microorganisms pigments bacteriorhodopsin in particular
CN101875508B (en) * 2010-05-31 2013-07-31 沈阳药科大学 A kind of preparation method and application of Fe3O4 nanometer magnetic powder lymphatic tracer
CN103495376A (en) * 2013-10-08 2014-01-08 江南大学 Preparation and phosphoeptide enrichment methods of titanium dioxide/ferroferric oxide nanoparticles
CN107973479A (en) * 2017-12-15 2018-05-01 河海大学 A kind of Magneto separate-distillation device and its application for being used to purify sewage and useful constituent recycling
CN207987068U (en) * 2017-12-29 2018-10-19 烟台安诺其精细化工有限公司 The purification devices of 4-ADPA crude product

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355319A (en) * 2001-12-07 2002-06-26 清华大学 Process for separating nucleic acid from biological particles by solid-phase carrier
CN101445277A (en) * 2008-11-14 2009-06-03 东北大学 Nano-crystalline Fe*O* particles with high absorption capacity and preparation method thereof
CN101612541A (en) * 2009-07-17 2009-12-30 江南大学 Preparation and application of polyacrylic acid-coated ferroferric oxide magnetic nanoparticles
US9121083B2 (en) * 2011-03-15 2015-09-01 Kabushiki Kaisha Toshiba Copper recovery apparatus and copper recovery method
JP2013146717A (en) * 2012-01-23 2013-08-01 Toshiba Corp Water treatment method and water treatment apparatus

Also Published As

Publication number Publication date
CN109382051A (en) 2019-02-26

Similar Documents

Publication Publication Date Title
CN103785857B (en) A kind of Nano Silver for antiseptic dressing and preparation method
CN106362148B (en) A method for coating and modifying Prussian blue nano-mesogenic cell membranes
CN109135220B (en) Polylactic acid/ZIF-8 @ C600 composite material and preparation method and application thereof
CN102093484B (en) Method for preparing nano crystal cellulose by dissociating ZnCl2
CN104785214A (en) Chitosan-coated magnetic mesoporous silica core-shell structured nanoparticle and preparation method and application thereof
CN108636367A (en) A kind of the chitosan magnetic composite material and preparation method of absorption PPCPs
CN109364889A (en) A kind of preparation method of thermosensitive hydrogel and use thereof
CN113181846B (en) Preparation method of pure lignin microcapsule based on Pickering emulsion solvent volatilization
Su et al. Polymer grafted mesoporous SBA-15 material synthesized via metal-free ATRP as pH-sensitive drug carrier for quercetin
CN107213875A (en) A kind of modified ramie porous microsphere sorbent of Adsorption of Heavy Metals ion and preparation method and application
CN102974326A (en) Preparation of silica-cyclodextrin nano-adsorbent and its application in the adsorption of heavy metal ions Cu2+ in sewage
CN109382051B (en) A kind of production system of nanometer biomedical material and its production process
WO2021027006A1 (en) Novel degradable hemostatic material and preparation method therefor
CN102093748A (en) Method for preparing radish red pigment homopolymer and radish proanthocyanidin from red-core radishes
CN106745878A (en) The recovery method of sericin in filature industrial wastewater
CN106861646B (en) Preparation method of adsorbent material for selectively adsorbing silver ions
CN103464222B (en) The preparation method of the special anion exchange resin of a kind of adsorbing liquaemin
CN107552810A (en) A kind of preparation method of Nano Silver isometric particle
CN107296802B (en) A kind of hydrophobic porous silicon curcumin microgel with antioxidant activity and preparation method thereof
CN107260560B (en) Preparation method of titanium dioxide special for cosmetics
CN103571221A (en) Extracting and purifying method of red-brown pigment of chestnut shells
CN105963274A (en) Preparation method of methylene blue containing silicon dioxide/tannin-iron particles promoting methylene blue monomer release
CN103240120B (en) Temperature switch type catalyst based on magnetic artificial cells
CN109865496A (en) Magnetic silica filler, magnetic affine filler and preparation method and purposes
CN109650602B (en) Method for removing antimony ions in water body by using magnetic adsorption material

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant