CN109381169A - A kind of quantization continuous blood pressure signal and the interactive method of physiological signal - Google Patents

A kind of quantization continuous blood pressure signal and the interactive method of physiological signal Download PDF

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CN109381169A
CN109381169A CN201811468196.1A CN201811468196A CN109381169A CN 109381169 A CN109381169 A CN 109381169A CN 201811468196 A CN201811468196 A CN 201811468196A CN 109381169 A CN109381169 A CN 109381169A
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signal
pulse wave
blood pressure
value
continuous
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宋嵘
陈华山
田娜
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Sun Yat Sen University
National Sun Yat Sen University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4809—Sleep detection, i.e. determining whether a subject is asleep or not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4812—Detecting sleep stages or cycles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4815—Sleep quality
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4818—Sleep apnoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors

Abstract

The invention belongs to medical monitoring arts, it discloses a kind of quantization continuous blood pressure signal and the interactive method of physiological signal, include the following steps: the linear relation model for correcting pulse wave translation time and blood pressure；Sleep physiology signal and pulse wave signal under synchronous and continuous acquisition sleep state；Eupnea section is respectively obtained according to the linear relation model of pulse wave translation time and blood pressure after correction and including continuous pressure value in respiration pause segment；According to transfer entropy calculation formula calculate separately eupnea section and sleep physiology signal including respiration pause segment to blood pressure transfer entropy, transfer entropy is used to quantify the reciprocation of continuous blood pressure signal Yu sleep physiology signal, to achieve the purpose that accurate quantification continuous blood pressure signal and sleep physiology signal interaction act on.

Description

A kind of quantization continuous blood pressure signal and the interactive method of physiological signal
Technical field
The present invention relates to medical monitoring arts, especially a kind of quantization continuous blood pressure signal and physiological signal are interactive Method.
Background technique
The sleep disturbance disease of apnea when sleep apnea low pass syndrome (SAHS) is a kind of sleep.Most often The reason of seeing is that the upper respiratory tract collapses or blocks, clinical manifestation predominantly sleep snoring, suppress doze off awake, daytime, fatigue etc., should Disease easily causes function of human body anoxic and hypercapnia occurs, and with the exacerbation of the course of disease, concurrently causes hypertension, glycosuria Disease and cardio-cerebrovascular diseases.It is shown according to epidemiologic data, SAHS is related to hypertension, foreign countries' report 45%~48% SAHS patient suffers from hypertension.The investigation of Chinese medical respirology branch sleep breathing disorders group in 2006 shows, China The Prevalence of Hypertension of SAHS crowd is 56.2%；Hypertension occurs in Ye You studies in China mechanism studies have shown that SAHS patient Rate is 49.3%, is far more than the 23.5% of normal population.Therefore, medical field thinks at present: SAHS be independently of the age, obesity, Smoking etc. causes one of the risk factor of hypertension.The hypertensive patient as caused by SAHS is easy to fail to pinpoint a disease in diagnosis since the state of an illness is more covert It is treated with affecting adversely, often finds that hypertension is just gone to a doctor, miss the best opportunity, give treatment addition many difficulty.
Current diagnosis SAHS generally acknowledges that most authoritative method is Polysomnography (PSG), the technology is highly developed, Generally, it can monitoring record subject include continuously sleep position, mouth and nose air-flow, electrocardio, blood oxygen saturation, brain in sleep A variety of sleep physiology parameters including electricity, for clinician's analyzing and diagnosing, but are unable to continuous blood pressure measuring value.It is most at present to do Method be before sleep monitor and subject wake up after respectively carry out a blood pressure measurement, can only play the role of comparison, referring to, it is even more impossible to from The relationship between sleep apnea low pass syndrome and blood pressure consecutive variations is inquired into the quantitative target that sleep monitor goes out.It can also To be monitored by synchronous 24 h ABPs of Polysomnography, but arterial pressure passes through cuff inflation and measure repeatedly, must So will affect subject ortho rule, and cuff inflation measurement be also based on certain time interval on the basis of (such as: Half an hour), rather than continuous continual monitoring.Due to monitoring means, the odjective causes such as individual difference, sleep physiology parameter It is still barely satisfactory with the result of study of blood pressure relationship.
Summary of the invention
The present invention is intended to provide a kind of quantization continuous blood pressure signal and the interactive method of physiological signal, it being capable of correct amount Change the relationship between sleep physiology parameter and blood pressure consecutive variations.
It is the specific scheme is that a kind of quantization continuous blood pressure signal and the interactive method of physiological signal, including walks as follows It is rapid:
Step 1: the linear relation model of pulse wave translation time and blood pressure are as follows: BP=a+b × PTT, wherein BP indicates blood Pressure value；PTT indicates pulse wave translation time；A and b be characterize blood pressure and pulse wave conduction time relationship individuation parameter, a and The calibration formula of b are as follows:
Wherein, BP1Indicate position chanP Before the pressure value measured, PTT1Pulse wave translation time before indicating position chanP, PTT2Pulse wave after indicating position chanP Conduction time；ρ indicates density of blood, ρ=1.035 × 103kg/m3；G indicates acceleration of gravity；Δ h indicates under different positions, into The height change value of position of human body at this of row blood pressure measurement；
The linear relation model of the pulse wave translation time and blood pressure is corrected according to the calibration formula of a and b；
Step 2: sleep physiology signal and pulse wave signal under synchronous and continuous acquisition sleep state；
Step 3: randomly selecting an eupnea section and one according to sleep physiology signal collected includes once exhaling Pause segment is inhaled, extracts the eupnea section respectively and described including collected complete, continuous in respiration pause segment Sleep physiology signal and pulse wave signal, pulse wave translation time is obtained according to extracted pulse wave signal, according to being obtained The pulse wave translation time taken respectively obtains described according to the linear relation model of pulse wave translation time and blood pressure after correction Eupnea section and it is described include respiration pause segment in continuous pressure value；
Step 4: respectively to the eupnea section and it is described include in respiration pause segment continuous pressure value extract Interval series, respectively to the eupnea section and it is described include in respiration pause segment continuous sleep physiology signal carry out Extract interval series by shooting, according to transfer entropy calculation formula calculate separately the eupnea section and it is described include respiration it is temporary Stop the sleep physiology signal of section to the transfer entropy of blood pressure, the transfer entropy is used to quantify continuous blood pressure signal and sleep physiology signal Reciprocation, the transfer entropy calculation formula are as follows:
Wherein TEx→yFor the transfer entropy of sleep physiology signal to blood pressure, τ is delay time, and x and y are sleep physiology letter respectively Number interval series and pressure value interval series.
The beneficial effects of the present invention are:
The present invention devises a kind of individuation parameter based on hydrostatic principle by change Body Position Change pressure value Standardization corrects the linear relation model of pulse wave translation time and blood pressure, can neither influence the sleep rule of subject, It again can be to avoid duplicate measurements blood pressure, the continuous blood pressure value obtained under sleep state easy to operate and high accuracy rate, Jin Erfen The transfer entropy of an eupnea section and the sleep physiology signal including respiration pause segment to blood pressure, accurate quantification are not obtained Relationship between sleep physiology parameter and blood pressure consecutive variations, know continuous blood pressure signal and sleep physiology signal interacts work With.
Detailed description of the invention
Fig. 1 is a kind of process for quantifying continuous blood pressure signal and physiological signal action method in the embodiment of the present invention Figure；
Fig. 2 is the linear relation model and AAMI blood pressure of pulse wave translation time and blood pressure after correcting in the embodiment of the present invention The blood pressure error comparison diagram of measurement standard.
Specific embodiment
With reference to embodiment, technical solution of the present invention is described in further detail.
As shown in Figure 1, quantization continuous blood pressure signal and the interactive method of physiological signal the following steps are included:
Step S1: the linear relation model of correction pulse wave translation time and blood pressure；
Linear relation model BP=a+b × PTT of existing pulse wave translation time and blood pressure, wherein BP indicates blood pressure Value；PTT indicates pulse wave translation time；A and b is the individuation parameter for characterizing blood pressure and pulse wave conduction time relationship, is only needed Obtain continuous pulse wave translation time, so that it may obtain according to the linear relation model of above-mentioned pulse wave translation time and blood pressure Continuous pressure value.
The prior art is to be completed by the measurement different BP value of multiple groups and corresponding PTT value to individuation parameter a and b value Calibration.But the scaling method has a two big disadvantages: first, it needs to carry out duplicate blood pressure survey using conventional cuff type sphygmomanometer Amount, continous way inflation/deflation will necessarily cause to squeeze to blood vessel, cause blood pressure measurement less than normal, and error increases.Second, for measurement Different pressure value out needs to make blood pressure that significant change occur in a short time by way of movement, complex for operation step.
Therefore, the present invention devises another based on hydrostatic principle by changing a of Body Position Change pressure value Body parameter calibration method can avoid duplicate measurements blood pressure, and easy to operate, derivation process is as follows:
According to hydrostatics, stationary fluid cannot bear shear stress, thus fluid matasomatism must in the power on the face element of boundary It must be vertical with these face elements.Consider a small size member of internal fluid, above and below product is dA, a height of dz, then under volume element The active force in face is pdA, and active force above isAccording to equilibrium condition, can be obtained: dp=- γ dz =-ρ gdz；
Wherein g is acceleration of gravity；Dp is the variable quantity of pressure；Dz is the variable quantity of fluid level；γ is the ratio of fluid Weight；ρ is fluid density, ρ=1.035 × 103kg/m3；
Relationship between the pressure change and height change of internal fluid certain point can be obtained by formula dp=- γ dz=- ρ gdz. According to the theory, blood flow in blood vessel is considered into several small sizes members, it is believed that certain blood flow in the volume element in a flash Be it is static, then can be obtained when change a certain section of blood vessel of body height when, pressure of the intravascular certain point for vascular wall The variation of power Δ p and the relationship of blood vessel height change h are Δ p=- ρ g Δ h, then the average change of this section of intravascular blood pressure Change
The scaling method of a and b can be designed according to formula above: measuring one group of corresponding pressure value BP first1And arteries and veins Fight wave conduction time PTT1, change position then to change blood vessel height change h, such as blood pressure measurement is using upper arm Formula electronic sphygmomanometer, the change of that position, which can be, raises Δ h for measurement arm, measures pulse wave translation time again, is denoted as PTT2, according to Δ BP=b Δ PTT, it may be determined that the calibration formula of parameter b are as follows:
Then the calibration formula of parameter a can be obtained are as follows:
The advantages of demarcating individuation parameter using this method is to can be avoided duplicate measurements blood pressure, it is only necessary to by changing Variant position can obtain the variation of blood pressure to change measurement blood vessel height change (such as: changing the height of measurement arm), thus Calibrate individuation parameter a and b.
Then, the linear relationship mould of the pulse wave translation time and blood pressure is corrected according to the calibration formula of a and b Type.
In the present embodiment, the linear of the pulse wave translation time and blood pressure is corrected according to the calibration formula of a and b Relational model concrete operations are as follows:
(1) allow subject using seat, left hand arm is placed on desk, and desk is consistent with cardiac height.It is eaten in left hand Refer to connection blood oxygen saturation probe, to detect pulse wave signal；
(2) the upper Arm-cuff device that testing calibration is crossed is connected in left hand simultaneously, measures blood pressure；
(3) subject's tranquillization 5 minutes are allowed, then starts to sample, it, should in 1 minutes of continuous acquisition after signal stabilization The pulse wave signal of subject, every acquisition measure blood pressure immediately afterward through upper Arm-cuff device in one minute, pass through pulse The pulse in one group of pressure value BP and 1 minutes can be obtained in the available pulse wave translation time value PTT of wave signal as a result, Wave conduction time value PTT, the average value for calculating this group of pressure value obtain BP1, calculate being averaged for this group of pulse wave translation time value Value obtains PTT1；
(4) same acquisition method is used, the measurement arm of subject is allowed to raise 20cm, then 1 minutes of continuous acquisition Interior pulse wave signal obtains the pulse wave translation time value PTT in one group of 1 minutes, calculates this group of arteries and veins under the state The average value for wave conduction time value of fighting obtains PTT2。
(5) according to the calibration formula of a and b, it can be deduced that 1 group of this subject of individuation parameter a, b value.
(6) in order to improve precision, subject is allowed to repeat above (1)~(5) step twice, in this way, the subject can divide 2 groups of individuation parameter a, b value is not obtained again.A, b value being averaged are the individuation parameter of the final subject.
In the following, to the linear relation model of pulse wave translation time and blood pressure using individuation parameter calibration formula correction It is verified, concrete operations are as follows:
Subject is respectively at seat, arm raises position, after clinostatism and movement under four kinds of states, under four kinds of states point Not Cai Ji pulse wave signal, when the pulse transit obtained using individuation parameter calibration formula correction according to step (1) to (6) Between with continuous blood pressure linear relation model, pressure value can be calculated, the pressure value calculated and actual measured value are compared, obtained Error amount out.
Referring to fig. 2, the results showed that using the pulse wave translation time and blood pressure of the individuation parameter calibration formula correction Linear relation model, calculate systolic pressure value when error be 2.675 ± 3.26mmHg, lower than AAMI blood pressure measurement standard 5 ± 8mmHg can be used for continuous measuring and calculating of the sleep period to systolic pressure value, can neither influence the sleep rule of subject, and can keep away Exempt from duplicate measurements blood pressure, the continuous blood pressure value under measuring and calculating sleep state easy to operate and high accuracy rate.
Step S2: sleep physiology signal and pulse wave signal under synchronous and continuous acquisition sleep state；
There are many kinds of sleep physiology signals, such as electrocardiosignal, oxygen saturation signal, respiratory air flow signal etc., these Signal can continuously be monitored by Polysomnography and be obtained.
In the present embodiment, sleep physiology signal is specially respiratory air flow signal, and pulse wave signal is held by connecting in finger Product pulse wave probe is to acquire；Respiratory air flow signal is acquired by connection heat-sensitive sensor and pressure sensor.
Step S3: eupnea is respectively obtained according to the linear relation model of pulse wave translation time and blood pressure after correction Section and including continuous pressure value in respiration pause segment；
The prior art can be according to sleep physiology signal to determine whether apnea under the sleep state, is pressed Randomly selecting an eupnea section and one according to step S2 respiratory air flow signal collected includes respiration pause segment, point Indescribably take the eupnea section and described including complete, the continuous breathing collected of step S2 in respiration pause segment Airflow signal and pulse wave signal obtain pulse wave translation time according to extracted pulse wave signal, according to acquired arteries and veins Wave conduction time of fighting respectively obtains described according to the linear relation model of pulse wave translation time and blood pressure after step S1 correction Eupnea section and it is described include respiration pause segment in continuous pressure value.
Step S4: eupnea section and sleep including respiration pause segment are calculated separately according to transfer entropy calculation formula Transfer entropy of the physiological signal to blood pressure.
Respectively to the eupnea section and it is described include in respiration pause segment continuous pressure value extract interphase sequence Arrange { BPi, i=1,2,3..., respectively to the eupnea section and it is described include respiration pause segment in continuously breathe Airflow signal carries out extracting interval series { RA by shootingi, i=1,2,3..., it is calculated separately according to transfer entropy calculation formula described The transfer entropy of eupnea section and the respiratory air flow signal including respiration pause segment to blood pressure, the transfer entropy calculating Formula are as follows:
Wherein TEx→yFor the transfer entropy of respiratory air flow signal to blood pressure, τ is delay time, and x and y are respiratory air flow letter respectively Number interval series RA and pressure value interval series BP.
Transfer entropy is used to quantify the reciprocation of continuous blood pressure signal Yu sleep physiology signal.
In the present embodiment, it is as follows to obtain result by step S1 to step S4 for a certain subject: eupnea Under state: TERA→BP=0.01163；Under breathing from suspending state: TERA→BP=0.00482.It was found that the transfer entropy of the two: passing Pass entropyEupnea> transfer entropyApnea, this result also provable generation apnea when, cardiovascular and pulmonary system coupling is to reduce , cardio-pulmonary function weakens, and realizes the interactive purpose of quantization continuous blood pressure signal and respiratory air flow signal.
The embodiment of the invention provides a kind of quantization continuous blood pressure signals and the interactive method of physiological signal, according to a Body parameter calibration method corrects the linear relation model of pulse wave translation time and blood pressure, randomly selects an eupnea section With including respiration pause segment, an eupnea section is obtained and including the continuous blood pressure value of respiration pause segment and breathing Airflow signal calculates the respiratory air flow signal under eupnea and breathing from suspending state to the transfer entropy of blood pressure, and makes comparisons, from And quantify the reciprocation of subject's angiocarpy and pulmonary system.This method is easy to operate, can quantitative, accurately and real-time get Required data provide theoretical direction for related diseases such as clinical prevention, diagnosis and treatment Sleep Apnea-hypopnea Syndromes.
Above-described is only presently preferred embodiments of the present invention, all made within the scope of the spirit and principles in the present invention What modifications, equivalent substitutions and improvements etc., should all be included in the protection scope of the present invention.

Claims (5)

1. a kind of quantization continuous blood pressure signal and the interactive method of physiological signal, which comprises the steps of:
Step 1: the linear relation model of pulse wave translation time and blood pressure are as follows: BP=a+b × PTT, wherein BP indicates blood pressure Value；PTT indicates pulse wave translation time；A and b is the individuation parameter for characterizing blood pressure and pulse wave conduction time relationship, a and b Calibration formula are as follows:
Wherein, BP1It is surveyed before indicating position chanP The pressure value measured, PTT1Pulse wave translation time before indicating position chanP, PTT2Pulse transit after indicating position chanP Time；ρ indicates density of blood, ρ=1.035 × 103kg/m3；G indicates acceleration of gravity；Δ h is indicated under different positions, is carried out blood Press the height change value of position of human body at this of measurement；
The linear relation model of the pulse wave translation time and blood pressure is corrected according to the calibration formula of a and b；
Step 2: sleep physiology signal and pulse wave signal under synchronous and continuous acquisition sleep state；
Step 3: randomly selecting an eupnea section and one according to sleep physiology signal collected includes that respiration is temporary Stop section, extract respectively the eupnea section and it is described include in respiration pause segment it is collected it is complete, continuously sleep Dormancy physiological signal and pulse wave signal obtain pulse wave translation time according to extracted pulse wave signal, according to acquired Pulse wave translation time respectively obtains described normal according to the linear relation model of pulse wave translation time and blood pressure after correction Breathe section and described including continuous pressure value in respiration pause segment；
Step 4: respectively to the eupnea section and it is described include in respiration pause segment continuous pressure value extract interphase Sequence, respectively to the eupnea section and it is described include in respiration pause segment continuous sleep physiology signal carry out by shooting Interval series are extracted, calculate separately the eupnea section according to transfer entropy calculation formula and described including respiration pause segment Sleep physiology signal to the transfer entropy of blood pressure, the transfer entropy is used to quantify the friendship of continuous blood pressure signal Yu sleep physiology signal Interaction, the transfer entropy calculation formula are as follows:
Wherein TEx→yFor the transfer entropy of sleep physiology signal to blood pressure, τ is delay time, and x and y are sleep physiology signal respectively The interval series of interval series and pressure value.
2. a kind of quantization continuous blood pressure signal according to claim 1 and the interactive method of physiological signal, feature It is,
BP1The pressure value measured before represented position chanP, the one group of pressure value specifically measured before position chanP are put down Mean value；
PTT1Pulse wave translation time before represented position chanP, the one group of pulse wave specifically measured before position chanP The average value of conduction time；
PTT2Pulse wave translation time after represented position chanP, the one group of pulse wave specifically measured after position chanP The average value of conduction time.
3. a kind of quantization continuous blood pressure signal according to claim 2 and the interactive method of physiological signal, feature It is, BP1、PTT1、PTT2Obtaining step are as follows:
Pulse wave signal in the continuous acquisition set time, every acquired once are surveyed immediately afterward through upper Arm-cuff device It takes blood pressure, by the available pulse wave translation time value of pulse wave signal, one group of pressure value and set time can be obtained as a result, Interior pulse wave translation time value, the average value for calculating this group of pressure value obtain BP1, calculate this group of pulse wave translation time value Average value obtains PTT1；
Change the pulse wave signal in position, then continuous acquisition same set time, then obtains in one group of same set time Pulse wave translation time value, the average value for calculating this group of pulse wave translation time value under the state obtain PTT2。
4. a kind of quantization continuous blood pressure signal according to claim 3 and the interactive method of physiological signal, feature It is,
The linear relation model of the pulse wave translation time and blood pressure is corrected according to the calibration formula of a and b, specifically:
Multiple groups individuation parameter a, b value is obtained according to the calibration formula of a and b, a, b value being averaged are final individuation Parameter, according to the linear relation model of pulse wave translation time and blood pressure described in the final individuation parameter correction.
5. a kind of quantization continuous blood pressure signal according to any one of claim 1 to 4 and physiological signal are interactive Method, which is characterized in that
The sleep physiology signal is respiratory air flow signal, the step 2 specifically: under synchronous and continuous acquisition sleep state Sleep physiology signal and pulse wave signal, wherein the pulse wave signal by finger connect volume pulsation wave probe adopt Collection, the respiratory air flow signal are acquired by connection heat-sensitive sensor and pressure sensor.
CN201811468196.1A 2018-10-16 2018-12-03 A kind of quantization continuous blood pressure signal and the interactive method of physiological signal Pending CN109381169A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111904404A (en) * 2020-08-06 2020-11-10 苏州国科医工科技发展(集团)有限公司 Blood pressure regulation and control equipment containing closed-loop monitoring and based on ear vagus nerve stimulation
CN113812936A (en) * 2021-10-14 2021-12-21 上海交通大学 Dynamic blood pressure monitoring system and calibration method of noninvasive continuous blood pressure measuring device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111904404A (en) * 2020-08-06 2020-11-10 苏州国科医工科技发展(集团)有限公司 Blood pressure regulation and control equipment containing closed-loop monitoring and based on ear vagus nerve stimulation
CN113812936A (en) * 2021-10-14 2021-12-21 上海交通大学 Dynamic blood pressure monitoring system and calibration method of noninvasive continuous blood pressure measuring device

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