CN109364294A - A kind of adsorbable artificial endocranium and preparation method thereof - Google Patents
A kind of adsorbable artificial endocranium and preparation method thereof Download PDFInfo
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- CN109364294A CN109364294A CN201811425216.7A CN201811425216A CN109364294A CN 109364294 A CN109364294 A CN 109364294A CN 201811425216 A CN201811425216 A CN 201811425216A CN 109364294 A CN109364294 A CN 109364294A
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- lactide
- poly
- caprolactone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
Abstract
The present invention provides a kind of adsorbable artificial endocranium and preparation method thereof, the one side that the artificial dura mater contacts with brain tissue is the porous structure surface formed by hydrophily biodegradated polymer materal, and the one side contacted with skull is the compact texture surface formed by hydrophobic biological degraded macromolecular material.Preparation method are as follows: compact texture film first is made in hydrophobic biological degraded macromolecular material；In one of face upper hydrophily biodegradated polymer materal solution of the compact texture film, it is freeze-dried, obtains porous structure face.The porous structure face obtained by freeze-drying, the size or pattern in hole can be regulated and controled according to freeze-drying condition, more conducively the docile of brain tissue cell, sprawl and grow, repairing effect can be improved；Preparation artificial dura mater is poured and is freeze-dried by the solution in dense film, and the combination on different structure surface is closer, is more advantageous to the leakage for preventing cerebrospinal fluid.
Description
Technical field
The present invention relates to a kind of adsorbable artificial endocranium and preparation method thereof, belong to technical field of biological material.
Background technique
Endocranium is one layer of connective tissue under skull, and for protecting brain tissue, operation of opening cranium will lead to dural damage
Wound and missing, dural defect will lead to the leakage of cerebrospinal fluid, easily lead to the infection of wound.Therefore, artificial dura mater for
Postoperative dural reparation is extremely important.One face contact brain tissue of endocranium, a face contact skull contact brain during reparation
Tissue is required to be conducive to the adherency of cell on one side, sprawls and grow to form new connective tissue, and contacts with skull
Require on one side its densification, to prevent the leakage of cerebrospinal fluid.Soft artificial dura mater is conducive to itself and wound edge endocranium
Suture.
Current adsorbable artificial endocranium is mostly multi-layer compound structure.The middle promulgated by the State Council of 105999419 A of Publication No. CN
Bright patent application discloses a kind of biomimetic prosthetic endocranium of double-layer structure, is lubricant layer with brain tissue contact side, in
Contain the natural polymer with lubricating action in portion；Promote endocranium regeneration zone away from side with brain tissue, internal is to pass through
The nanofiber that electrostatic spinning obtains is in height-oriented arrangement.The Chinese invention patent application of 106310367 A of Publication No. CN
It discloses and the dural method of single layered porous adsorbable artificial is prepared by electrostatic spinning.106215243 A's of Publication No. CN
Chinese invention patent application discloses a kind of novel hydrophilic antiseep absorbable medical film and preparation method thereof, this medical films tool
While the three-deckers such as standby hydrophilic layer, absorbed layer, anti-leakage layer, absorbed layer can be good at absorptive tissue sepage and guarantee group
Surrounding tissue will not be leaked by knitting sepage.The Chinese invention patent application of Publication No. CN103418031 A discloses a kind of multiple
Absorbable dural patch is closed, the mesh-type patches of braiding are combined on antiseepage tunic by hot pressing, then again by bioactivity
Substance is added in mesh sheet, promotes dural reparation.
But the aperture of the artificial dura mater material surface of the method for above-mentioned patent disclosure preparation is smaller, only several microns,
And cell is generally 20~30 μm, cell cannot be introduced into the pore structure of artificial dura mater material surface, can only be on the surface of the material
Growth, to keep the time to form connective tissue long, influences postoperative recovery effects.
Summary of the invention
Goal of the invention: it is smaller for existing artificial dura mater aperture, be unfavorable for brain tissue growth, repairing effect difference ask
Topic, the present invention provide a kind of adsorbable artificial endocranium with a face porous structure one side compact texture, and provide a kind of be somebody's turn to do
The preparation method of artificial dura mater.
Technical solution: a kind of adsorbable artificial endocranium of the present invention, what which contacted with brain tissue
On one side for the porous structure surface formed by hydrophily biodegradated polymer materal, the one side contacted with skull is by hydrophobicity
The compact texture surface that biodegradated polymer materal is formed.
The thickness of above-mentioned artificial dura mater is less than 1 millimeter.
Wherein, hydrophily biodegradated polymer materal is preferably polylactide-polyethylene glycol-polylactide, gathers in
Ester-polyethylene glycol caprolactone, poly- (lactide coglycolide)-polyethylene glycol (lactide coglycolide), poly- (lactide-
Glycolide-caprolactone)-polyethylene glycol (lactide coglycolide-caprolactone), poly- (lactide-caprolactone)-polyethylene glycol-
At least one of poly- (lactide-caprolactone) copolymer.Preferably poly- (the lactide-of hydrophobic biological degraded macromolecular material
Glycolide), poly- (lactide coglycolide-caprolactone), at least one of poly- (lactide-caprolactone).
The dural preparation method of adsorbable artificial of the present invention, includes the following steps:
(1) compact texture film is made in hydrophobic biological degraded macromolecular material；
(2) in one of face upper hydrophily biodegradated polymer materal solution of the compact texture film, freezing
Drying obtains porous structure face, and the material of the face porous structure one side compact texture is adsorbable artificial endocranium.
Preferably, in step (1), hydrophobic biological degraded macromolecular material passes through the side of curtain coating, extrusion or Blown Film
Compact texture film is prepared in formula.
In above-mentioned steps (2), the solvent of hydrophily biodegradated polymer materal solution is preferably dioxane.
The utility model has the advantages that compared with existing artificial dura mater, artificial dura mater of the invention have it is fine and close, while it is more
The different structure in hole, the porous structure face contacted with brain tissue can promote brain tissue growth, and the compact surfaces contacted with skull can
It prevents cerebrospinal fluid from leaking, there is preferable repairing effect；Moreover, preparing artificial dura mater using method of the invention, on the one hand,
The porous structure face obtained by freeze-drying, the size or pattern in hole can be regulated and controled according to freeze-drying condition, can get
The pore structure that pore diameter range is 20~100 microns, moreover, these pore structures are through hole, brain tissue cell can be grown into hole,
More conducively the docile of brain tissue cell, sprawl and grow, repairing effect can be improved；On the other hand, by molten in dense film
Liquid pours and is freeze-dried the adsorbable artificial endocranium of the two-sided different structure of preparation, and the combination on different structure surface is tighter
It is close, it is more advantageous to the leakage for preventing cerebrospinal fluid.
Detailed description of the invention
Fig. 1 is the SEM photograph in the dural porous structure face of adsorbable artificial made from embodiment 1；
Fig. 2 is the SEM photograph in the dural compact texture face of adsorbable artificial made from embodiment 1；
Fig. 3 is adsorbable artificial endocranium made from embodiment 1 after porous surface inoculating cell, under different focal planes
Laser confocal microscope tomoscan photo, wherein grey parts are cell.
Specific embodiment
Technical solution of the present invention is described further below with reference to embodiment.
Adsorbable artificial endocranium of the invention, thickness are less than 1mm, and one side is porous structure face, and material therefor is parent
Aqueous biological degraded macromolecular material, another side are compact texture face, and material therefor is hydrophobic biological degraded macromolecular material；
Wherein, what is contacted with brain tissue is porous structure one side, and what is contacted with skull is compact texture face.
By in the compound another Biodegradable high molecular solution of fine and close degradable macromolecule film surface, and it is dry by freezing
Dry method, can be prepared it is of the invention have it is fine and close, while porous different structure adsorbable artificial endocranium.
Embodiment 1
Raw material: poly- (lactide coglycolide)-polyethylene glycol (lactide-second of hydrophily biodegradated polymer materal
Lactide) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide-caprolactone).
The preparation method comprises the following steps: poly- (lactide-caprolactone) material prepares dense face by Blown Film, by poly- (lactide-second
Lactide)-polyethylene glycol (lactide coglycolide) copolymer material dioxane solution be cast in it is poly- (lactide-in
Ester) on material membrane, by freeze-drying, porous surface is obtained, this two-sided film with different surfaces structure is to can absorb
Artificial dura mater.
The SEM photograph of its porous surface and compact surfaces is respectively such as Fig. 1~2, it can be seen that porous surface has apparent
Pore structure, and aperture is 20~100 μm.The dural porous surface inoculating cell of the adsorbable artificial made from the present embodiment
Afterwards, tomoscan photo such as Fig. 3, B1-B4 of laser confocal microscope are different focal planes, wherein grey parts are thin
Born of the same parents, it can be seen that cell has grown into the inside of porous layer, it is seen then that it is thin that artificial dura mater produced by the present invention is conducive to brain tissue
The docile of born of the same parents is sprawled and is grown, and can promote the reparation of brain tissue.
Embodiment 2
Raw material: hydrophily biodegradated polymer materal polylactide-polyethylene glycol-polylactide copolymer, hydrophobicity
Biodegradated polymer materal is poly- (lactide coglycolide).
Preparation method: poly- (lactide coglycolide) material prepares dense face by casting film-forming, by the poly- second of polylactide-
Glycol-polylactide co polymer material dioxane solution is cast on poly- (lactide coglycolide) film, dry by freezing
It is dry, porous surface is obtained, this two-sided film with different surfaces structure is adsorbable artificial endocranium.Its porous surface and
The morphological structure of compact surfaces is close with embodiment 1.
Embodiment 3
Raw material: hydrophily biodegradated polymer materal pla-pcl-polyethylene glycol caprolactone copolymers, hydrophobicity
Biodegradated polymer materal is poly- (lactide coglycolide-caprolactone).
The preparation method comprises the following steps: poly- (lactide coglycolide-caprolactone) material prepares dense face by film extrusion, will gather
Lactone-polyethylene glycol caprolactone copolymers material dioxane solution is cast in poly- (lactide coglycolide-caprolactone)
On material membrane, by freeze-drying, porous surface, this two-sided hard brain of film adsorbable artificial with different surfaces structure are obtained
Film.The morphological structure of its porous surface and compact surfaces is close with embodiment 1.
Embodiment 4
Raw material: poly- (lactide coglycolide-the caprolactone)-polyethylene glycol (third of hydrophily biodegradated polymer materal
Lactide-co-glycolides-caprolactone) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide coglycolide).
The preparation method comprises the following steps: poly- (lactide coglycolide) material prepares dense face by casting film-forming, by poly- (lactide-second
Lactide-caprolactone) dioxane solution of-polyethylene glycol (lactide coglycolide-caprolactone) copolymer material is cast in
On poly- (lactide coglycolide) material membrane, by freeze-drying, porous surface is obtained, it is this two-sided with different surfaces structure
Film be adsorbable artificial endocranium.The morphological structure of its porous surface and compact surfaces is close with embodiment 1.
Embodiment 5
Raw material: (lactide-is for poly- (the lactide-caprolactone)-polyethylene glycol of hydrophily biodegradated polymer materal
Lactone) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide coglycolide-caprolactone).
The preparation method comprises the following steps: poly- (lactide coglycolide-caprolactone) material prepares dense face by Blown Film, by poly- (third
Lactide-caprolactone)-polyethylene glycol (lactide-caprolactone) copolymer material dioxane solution be cast in it is poly- (third hand over
Ester-glycolide-caprolactone) on material membrane, by freeze-drying, obtain porous surface, this two-sided have different surfaces structure
Film be adsorbable artificial endocranium.The morphological structure of its porous surface and compact surfaces is close with embodiment 1.
Embodiment 6
Raw material: poly- (lactide coglycolide)-polyethylene glycol (lactide-second of hydrophily biodegradated polymer materal
Lactide) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide coglycolide).
The preparation method comprises the following steps: poly- (lactide coglycolide) material prepares dense face by Blown Film, by poly- (lactide-second
Lactide) dioxane solution of-polyethylene glycol (lactide coglycolide) copolymer material is cast in that poly- (lactide-second is handed over
Ester) on material membrane, by freeze-drying, porous surface is obtained, this two-sided film with different surfaces structure is to can absorb
Artificial dura mater.The morphological structure of its porous surface and compact surfaces is close with embodiment 1.
Embodiment 7
Raw material: poly- (lactide coglycolide-the caprolactone)-polyethylene glycol (third of hydrophily biodegradated polymer materal
Lactide-co-glycolides-caprolactone) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide coglycolide-caprolactone).
The preparation method comprises the following steps: poly- (lactide coglycolide-caprolactone) material prepares dense face by casting film-forming, by poly- (third
Lactide-co-glycolides-caprolactone)-polyethylene glycol (lactide coglycolide-caprolactone) copolymer material dioxane solution
It is cast on poly- (lactide coglycolide-caprolactone) material membrane, by freeze-drying, obtains porous surface, this two-sided have
The film of different surfaces structure is adsorbable artificial endocranium.The morphological structure and implementation of its porous surface and compact surfaces
It is close in example 1.
Embodiment 8
Raw material: (lactide-is for poly- (the lactide-caprolactone)-polyethylene glycol of hydrophily biodegradated polymer materal
Lactone) copolymer, hydrophobic biological degraded macromolecular material is poly- (lactide-caprolactone).
The preparation method comprises the following steps: poly- (lactide-caprolactone) material prepares dense face by film extrusion, by it is poly- (lactide-oneself
Lactone)-polyethylene glycol (lactide-caprolactone) copolymer material dioxane solution be cast in it is poly- (lactide-in
Ester) on material membrane, by freeze-drying, porous surface is obtained, this two-sided film with different surfaces structure is to can absorb
Artificial dura mater.The morphological structure of its porous surface and compact surfaces is close with embodiment 1.
Embodiment 9
Raw material: hydrophily biodegradated polymer materal polylactide-polyethylene glycol-polylactide copolymer, hydrophobicity
Biodegradated polymer materal is poly- (lactide-caprolactone).
The preparation method comprises the following steps: poly- (lactide-caprolactone) material prepares dense face by casting film-forming, polylactide-is poly-
Ethylene glycol-polylactide co polymer material dioxane solution is cast on poly- (lactide-caprolactone) material membrane, by cold
Be lyophilized it is dry, obtain porous surface, this two-sided film with different surfaces structure is adsorbable artificial endocranium.Its porous table
The morphological structure of face and compact surfaces is close with embodiment 1.
Claims (7)
1. a kind of adsorbable artificial endocranium, which is characterized in that the one side that the artificial dura mater contacts with brain tissue is by hydrophilic
Property the porous structure surface that is formed of biodegradated polymer materal, one side contact with skull is degrades high score by hydrophobic biological
The compact texture surface that sub- material is formed.
2. adsorbable artificial endocranium according to claim 1, which is characterized in that the hydrophily Biodegradable high molecular
Material is polylactide-polyethylene glycol-polylactide, pla-pcl-polyethylene glycol caprolactone, poly- (lactide-second is handed over
Ester)-polyethylene glycol (lactide coglycolide), poly- (lactide coglycolide-caprolactone)-polyethylene glycol (lactide-second
Lactide-caprolactone), at least one of poly- (lactide-caprolactone)-polyethylene glycol (lactide-caprolactone) copolymer.
3. adsorbable artificial endocranium according to claim 1, which is characterized in that the hydrophobic biological degraded macromolecular
Material is poly- (lactide coglycolide), poly- (lactide coglycolide-caprolactone), at least one in poly- (lactide-caprolactone)
Kind.
4. adsorbable artificial endocranium according to claim 1, which is characterized in that the thickness of the artificial dura mater is less than
1 millimeter.
5. a kind of dural preparation method of adsorbable artificial described in claim 1, which is characterized in that include the following steps:
(1) compact texture film is made in the hydrophobic biological degraded macromolecular material；
(2) in one of face upper hydrophily biodegradated polymer materal solution of the compact texture film, be freeze-dried,
Porous structure face is obtained, the material of the face porous structure one side compact texture is adsorbable artificial endocranium.
6. the dural preparation method of adsorbable artificial according to claim 5, which is characterized in that described in step (1)
Compact texture film is prepared in hydrophobic biological degraded macromolecular material by way of curtain coating, extrusion or Blown Film.
7. the dural preparation method of adsorbable artificial according to claim 5, which is characterized in that described in step (2)
The solvent of hydrophily biodegradated polymer materal solution is dioxane.
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| CN111330079A (en) * | 2020-03-31 | 2020-06-26 | 江苏白衣缘生物工程有限公司 | Artificial dura mater composite patch |
| CN111420123A (en) * | 2020-03-16 | 2020-07-17 | 江西光至金辉医疗制品有限公司 | Degradable anti-adhesion double-layer dura mater patch and preparation method thereof |
| CN112107736A (en) * | 2020-09-23 | 2020-12-22 | 成都美益达医疗科技有限公司 | Absorbable endocranium and preparation method thereof |
| CN114259324A (en) * | 2021-12-24 | 2022-04-01 | 天新福（北京）医疗器材股份有限公司 | Preparation method of multilayer artificial dura mater |
| CN114887119A (en) * | 2022-05-09 | 2022-08-12 | 浙江大学医学院附属第一医院 | High-molecular artificial dura mater with anti-infection capacity and preparation method thereof |
| CN115154658A (en) * | 2022-04-21 | 2022-10-11 | 中山大学附属第八医院（深圳福田） | Preparation method and application of water-absorbing self-adhesive dura mater patch |
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| CN109364294B (en) | 2019-12-17 |
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