CN109364204A - A kind of Herbal compound capsule and preparation method thereof reducing uric acid - Google Patents

A kind of Herbal compound capsule and preparation method thereof reducing uric acid Download PDF

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CN109364204A
CN109364204A CN201811317460.1A CN201811317460A CN109364204A CN 109364204 A CN109364204 A CN 109364204A CN 201811317460 A CN201811317460 A CN 201811317460A CN 109364204 A CN109364204 A CN 109364204A
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parts
extract
uric acid
preparation
vitex negundo
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魏道智
李恒
宁书菊
吴童
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Fujian Vocational College Of Bioengineering
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Fujian Vocational College Of Bioengineering
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Abstract

The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Herbal compound capsule and preparation method thereof for reducing uric acid.Its raw material includes: by weight; 11-15 parts of Rhizoma Smilacis Glabrae extract; 11-15 parts of phellinus linteus extract, 7-12 parts of Rhizoma Chuanxiong extract, 7-11 parts of Vitex negundo var cannabifolia extract; 7-11 parts of Rhizoma Atractylodis Macrocephalae extract; 7-11 parts of Polygala fallax Hemsl, 7-11 parts of eucommia ulmoides extracts, 7-12 parts of Retinervus Luffae Fructus extract; 7-11 parts of dandelion extract, 7-11 parts of Vitex negundo var cannabifolia ash alkali extract.The present invention is served as theme with wind-expelling pain-stopping, on the basis of help is strong dirty, sensible qi and blood channels and collaterals, heat-clearing and damp-drying drug Li Shui, improve patient cellular immunity simultaneously, adjust uric acid metabolism, the effect of acid suppression, molten acid and acid, acid discharge, traditional medicine and modern medicine match well, play deacidification eliminating impediment altogether.

Description

A kind of Herbal compound capsule and preparation method thereof reducing uric acid
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to it is a kind of reduce uric acid Herbal compound capsule and its preparation side Method.
Background technique
Gout is a kind of crystal correlation arthropathy that monosodium urate salt (MSU) deposition is caused, is produced with purine metabolic disturbance Raw uric acid and (or) hyperuricemia caused by underexcretion is directly related, belong to metabolic rheumatic disorder scope.It is urinated in blood When acid concentration is excessively high, uric acid can be precipitated in the form of small sodium salt crystal, be accumulated in joint, cartilage and kidney, and inflammation is caused, Gout can concurrent renal lesions, serious person may occur in which destruction of joint, kidney function damage, and prognostic is poor.
Western medical treatment gout promotes the excretion of uric acid in blood first is that reducing kidney to the re-absorption of uric acid；Second is that reducing Uric acid synthesis, and then reduce uric acid concentration in blood.The former disadvantage is that urate crystals can be caused in the deposition of urinary tract, is caused Renal colic and kidney function damage.The latter will appear fash, gastrointestinal reaction and oligoleukocythemia, the damage of hepatic and renal function.Moral State angstrom erlang root university research points out that the neutrophil cell of human immune system may participate in inflammatory reaction caused by gout, catches Uric acid crystal is obtained, wraps up and dissolves, therefore with Chinese medicine by improving autoimmunity antigout, biochemical basis with uniformity.
Chinese medicine thinks that gout belongs to rheumatism scope, first is that damp-heat arthralgia hinders, damp and hot aggregation limbs joint causes redness scorching hot, Swelling pain needs removing damp-heat, promoting blood circulation and removing obstruction in channels；Second is that blood stasis phlegm hinders, it is believed that bi Zheng with the passing of time, the unfavorable and stasis of blood of meridian qi and blood operation Resistance, stays in joint, answers activating microcirculation and removing stasis medicinal, eleminating phlegm and freeing channels；Third is that caused by liver and kidney deficiency.Think with the passing of time bi Zheng is not cured, injure liver kidney, causes sun Unsaturated vapor, table are defended not solid, and shape tremble with fear limb cold, and to cold sensitivity, arthralgia aggravates, must tonify the liver and kidney, eliminating dampness and dredging channels.Chinese medicine is only said The prognosis of result and degeneration variation after gout occurs out.Clearing and activating the channels and collaterals and strong strengthening yang, can reinforce local generation really It thanks to the reduction with local uric acid, increases the excretion of kidney, but compatibility of drugs is bad, compares and is difficult to reach remission effect.
Summary of the invention
The purpose of the present invention is to provide a kind of Herbal compound capsules and preparation method thereof for reducing uric acid.We are with native Fu Based on Siberian cocklebur and Phellinus, acid discharge, acid suppression；With Rhizoma Chuanxiong, Vitex negundo var cannabifolia blood-activating and qi-promoting, stagnation resolvation, qi-regulating is promoted blood circulation, wind-expelling pain-stopping；With Rhizoma Atractylodis Macrocephalae invigorating the spleen QI invigorating, eliminate dampness and have diuretic effect improve cellular immune function；With false-yellowflower milkwort root or herb tonifying Qi and blood, invigorating spleen to remove dampness is promoting blood circulation and removing obstruction in channels；It is posted with mulberry Life, Phellinus, Cortex Eucommiae tonify the liver and kidney, and strengthen muscles and bones, coordinating Chong and Conception Vessels；It is clearing heat and detoxicating with luffa, dandelion, diuresis dissipating bind, detumescence, It passes through eliminating impediment, with Vitex negundo var cannabifolia ash alkali neutralization uric acid, full side is with tonifying Qi and blood, and invigorating the spleen is tonified the liver and kidney, the promoting flow of qi and blood circulation, stagnation resolvation, heat-clearing solution Poison, eliminate dampness and have diuretic effect, wind-expelling pain-stopping are served as theme, and on the basis of help is strong dirty, sensible qi and blood channels and collaterals, heat-clearing and damp-drying drug Li Shui is being mentioned The cellular immunity of high patient simultaneously, adjusts uric acid metabolism, and acid suppression, molten acid and acid, acid discharge, traditional medicine and modern medicine match well, The effect of playing deacidification eliminating impediment altogether.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of Herbal compound capsule reducing uric acid, raw material includes: 11-15 parts of Rhizoma Smilacis Glabrae extract by weight, mulberry Yellow extract 11-15 parts, 7-12 parts of Rhizoma Chuanxiong extract, 7-11 parts of Vitex negundo var cannabifolia extract, 7-11 parts of Rhizoma Atractylodis Macrocephalae extract, chrysanthemum falls 7-11 parts of water lotus extract, 7-11 parts of eucommia ulmoides extracts, 7-12 parts of Retinervus Luffae Fructus extract, dandelion extract 7-11 Part, 7-11 parts of Vitex negundo var cannabifolia ash alkali extract.
A kind of preparation method for the Herbal compound capsule reducing uric acid, comprising the following steps:
(1) drug extracts: smilax, Phellinus, Rhizoma Chuanxiong, Rhizoma Atractylodis Macrocephalae, false-yellowflower milkwort root or herb, Cortex Eucommiae, luffa, dandelion being taken to carry out respectively Extract preparation, specific extracting method are as follows: raw material is crushed to 0.5-1.5cm, with 90vol% alcohol, solid-liquid ratio 1/10~15 (w/w), 70~80 DEG C, 0.06~0.09 Mba of pressure, vacuum rotating 2.5~3.0 h of reflux flow back 3 times, combined extract, Concentration, rotary evaporation in vacuo are concentrated into medicinal extract (20~30% w/w of crude drug), admix soluble starch (1/1~2 w/w)；
(2) Vitex negundo var cannabifolia ash alkali extract: taking Vitex negundo var cannabifolia branches and leaves in 3~April, cremates as ash, and distilled water dissolves (1/2~3 v/v), filtering, It steams to the 1/5~1/6 of original volume, admixes soluble starch (1/1~2 w/w).
(3) preparation: according to drug composition ratio, each extract is mixed, is packed into capsule.
Remarkable advantage of the invention is: being combined using traditional medicine and modern medicine, with Chinese medicine invigorating the spleen, help liver Kidney, the promoting flow of qi and blood circulation, activating microcirculation and removing stasis medicinal, eliminate dampness and have diuretic effect, wind-expelling pain-stopping, while improving body immunity, adjust the synthesis of uric acid and dividing Solution reaches acid suppression, deacidification, the comprehensive therapeutic purposes of molten acid and acid, acid discharge, uric acid is made to revert to normal range (NR).
Specific embodiment
Further to disclose rather than the present invention is limited, the present invention is described in further detail below in conjunction with example.
Embodiment 1
A kind of Herbal compound capsule reducing uric acid, raw material includes: 11 parts of Rhizoma Smilacis Glabrae extract by weight, Phellinus 11 parts of extract, 7 parts of Rhizoma Chuanxiong extract, 7 parts of Vitex negundo var cannabifolia extract, 7 parts of Rhizoma Atractylodis Macrocephalae extract, Polygala fallax Hemsl 7 Part, 7 parts of eucommia ulmoides extracts, 7 parts of Retinervus Luffae Fructus extract, 7 parts of dandelion extract, 7 parts of Vitex negundo var cannabifolia ash alkali extract.
A kind of preparation method for the Herbal compound capsule reducing uric acid, comprising the following steps:
(1) drug extracts: smilax, Phellinus, Rhizoma Chuanxiong, Rhizoma Atractylodis Macrocephalae, false-yellowflower milkwort root or herb, Cortex Eucommiae, luffa, dandelion being taken to carry out respectively Extract preparation, specific extracting method are as follows: raw material is crushed to 0.5cm, with 90vol% alcohol, solid-liquid ratio 1/10(w/w), 80 DEG C, 0.09 Mba of pressure, vacuum rotating 3.0 h of reflux flow back 3 times, combined extract, concentration, rotary evaporation in vacuo are concentrated into Medicinal extract (30% w/w of crude drug), admixes soluble starch (1/1 w/w)；
(2) Vitex negundo var cannabifolia ash alkali extract: taking Vitex negundo var cannabifolia branches and leaves in 3~April, cremates as ash, and distilled water dissolves (1/2 v/v), filtering, steams extremely Soluble starch (1/1 w/w) is admixed in the 1/5 of original volume.
(3) preparation: according to drug composition ratio, each extract is mixed, is packed into capsule.
Embodiment 2
A kind of Herbal compound capsule reducing uric acid, raw material includes: 13 parts of Rhizoma Smilacis Glabrae extract by weight, Phellinus 13 parts of extract, 10 parts of Rhizoma Chuanxiong extract, 9 parts of Vitex negundo var cannabifolia extract, 9 parts of Rhizoma Atractylodis Macrocephalae extract, false-yellowflower milkwort root or herb extracts 9 parts of object, 9 parts of eucommia ulmoides extracts, 10 parts of Retinervus Luffae Fructus extract, 9 parts of dandelion extract, Vitex negundo var cannabifolia ash alkali extract 9 Part.
A kind of preparation method for the Herbal compound capsule reducing uric acid, comprising the following steps:
(1) drug extracts: smilax, Phellinus, Rhizoma Chuanxiong, Rhizoma Atractylodis Macrocephalae, false-yellowflower milkwort root or herb, Cortex Eucommiae, luffa, dandelion being taken to carry out respectively Extract preparation, specific extracting method are as follows: raw material is crushed to 0.5cm, with 90vol% alcohol, solid-liquid ratio 1/10(w/w), 80 DEG C, 0.09 Mba of pressure, vacuum rotating 3.0 h of reflux flow back 3 times, combined extract, concentration, rotary evaporation in vacuo are concentrated into Medicinal extract (30% w/w of crude drug), admixes soluble starch (1/2 w/w)；
(2) Vitex negundo var cannabifolia ash alkali extract: taking Vitex negundo var cannabifolia branches and leaves in 3~April, cremates as ash, and distilled water dissolves (1/2 v/v), filtering, steams extremely Soluble starch (1/1 w/w) is admixed in the 1/5 of original volume.
(3) preparation: according to drug composition ratio, each extract is mixed, is packed into capsule.
Embodiment 3
A kind of Herbal compound capsule reducing uric acid, raw material includes: 15 parts of Rhizoma Smilacis Glabrae extract by weight, Phellinus 15 parts of extract, 12 parts of Rhizoma Chuanxiong extract, 11 parts of Vitex negundo var cannabifolia extract, 11 parts of Rhizoma Atractylodis Macrocephalae extract, Polygala fallax Hemsl 11 parts, 11 parts of eucommia ulmoides extracts, 12 parts of Retinervus Luffae Fructus extract, 11 parts of dandelion extract, Vitex negundo var cannabifolia ash alkali extract 11 Part.
A kind of preparation method for the Herbal compound capsule reducing uric acid, comprising the following steps:
(1) drug extracts: smilax, Phellinus, Rhizoma Chuanxiong, Rhizoma Atractylodis Macrocephalae, false-yellowflower milkwort root or herb, Cortex Eucommiae, luffa, dandelion being taken to carry out respectively Extract preparation, specific extracting method are as follows: raw material is crushed to 0.5cm, with 90vol% alcohol, solid-liquid ratio 1/10(w/w), 80 DEG C, 0.09 Mba of pressure, vacuum rotating 3.0 h of reflux flow back 3 times, combined extract, concentration, rotary evaporation in vacuo are concentrated into Medicinal extract (30% w/w of crude drug), admixes soluble starch (1/2 w/w)；
(2) Vitex negundo var cannabifolia ash alkali extract: taking Vitex negundo var cannabifolia branches and leaves in 3~April, cremates as ash, and distilled water dissolves (1/2 v/v), filtering, steams extremely Soluble starch (1/1 w/w) is admixed in the 1/5 of original volume.
(3) preparation: according to drug composition ratio, each extract is mixed, is packed into capsule.
Modeling and administration: healthy weight about 200g adult male SD rats are randomly assigned, every group 10, are divided into control group, Positive controls and medication group.Positive controls and medication group give rats gavaged adenine with the dosage of 100mg/kg weight, often It is gavaged 1 time, can be measured serum uric acid level within 20th in administration and be increased, modeling success.Medication group is according to 2.5g/kg weight Dosage to the preparation of the above-mentioned filling capsule of rats gavaged, control group and positive controls take same dosage soluble starch, 2 weeks After measure biochemical indicator.
The biochemical indicator test that one each group of table
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with repair Decorations, are all covered by the present invention.

Claims (6)

1. a kind of Herbal compound capsule for reducing uric acid, it is characterised in that: its raw material includes: that by weight, smilax extracts 11-15 parts of object, 11-15 parts of phellinus linteus extract, 7-12 parts of Rhizoma Chuanxiong extract, 7-11 parts of Vitex negundo var cannabifolia extract, Rhizoma Atractylodis Macrocephalae extract 7-11 parts, 7-11 parts of Polygala fallax Hemsl, 7-11 parts of eucommia ulmoides extracts, 7-12 parts of Retinervus Luffae Fructus extract, Pu Gong 7-11 parts of English extract, 7-11 parts of Vitex negundo var cannabifolia ash alkali extract.
2. a kind of Herbal compound capsule for reducing uric acid according to claim 1, it is characterised in that: its raw material includes: soil 13 parts of tuckahoe extracts, 13 parts of phellinus linteus extract, 10 parts of Rhizoma Chuanxiong extract, 9 parts of Vitex negundo var cannabifolia extract, Rhizoma Atractylodis Macrocephalae extracts 9 parts of object, 9 parts of Polygala fallax Hemsl, 9 parts of eucommia ulmoides extracts, 10 parts of Retinervus Luffae Fructus extract, dandelion extract 9 parts, 9 parts of Vitex negundo var cannabifolia ash alkali extract.
3. a kind of method for preparing the as described in claim 1 Herbal compound capsule for reducing uric acid, it is characterised in that: including with Lower step:
(1) smilax, Phellinus, Rhizoma Chuanxiong, Rhizoma Atractylodis Macrocephalae, false-yellowflower milkwort root or herb, Cortex Eucommiae, luffa, dandelion the preparation of drug extract: are taken Object preparation, specific extracting method are extracted respectively are as follows: raw material is crushed to 0.5-1.5cm, with 90vol% alcohol, 70~80 DEG C, 0.06~0.09 Mba of pressure, vacuum rotating 2.5~3.0 h of reflux flow back 3 times, combined extract, concentration, vacuum rotating It is concentrated by evaporation to medicinal extract, admixes soluble starch；
(2) Vitex negundo var cannabifolia ash alkali extract: taking Vitex negundo var cannabifolia branches and leaves in 3~April, cremates as ash, with distilled water dissolution, the filtering of 2 ~ 3 times of volumes, It steams to the 1/5~1/6 of original volume, obtains Vitex negundo var cannabifolia ash alkali extract, admix soluble starch；
(3) preparation: according to drug composition ratio, each extract is mixed, is packed into capsule.
4. the preparation method of the Herbal compound capsule according to claim 1 for reducing uric acid, it is characterised in that: including following Step: the solid-liquid ratio of drug and alcohol is 1/10~15(w/w in step (1)).
5. the preparation method of the Herbal compound capsule according to claim 1 for reducing uric acid, it is characterised in that:
Step (1) medicinal extract is 20~30% w/w of crude drug；The mass ratio of the additional amount of soluble starch and medicinal extract is 1 ~ 2:1。
6. the preparation method of the Herbal compound capsule according to claim 1 for reducing uric acid, it is characterised in that: step (2) The mass ratio of middle soluble starch additional amount and Vitex negundo var cannabifolia ash alkali extract is 1 ~ 2:1.
CN201811317460.1A 2018-11-07 2018-11-07 A kind of Herbal compound capsule and preparation method thereof reducing uric acid Pending CN109364204A (en)

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Application publication date: 20190222