CN109350351B

CN109350351B - Simple device for abdominal local thermal chemotherapy

Info

Publication number: CN109350351B
Application number: CN201811292651.7A
Authority: CN
Inventors: 陈新华; 林周盛; 余江; 李国新; 李团结; 陈粤泓; 李涛
Original assignee: Southern Medical University
Current assignee: Southern Medical University
Priority date: 2018-10-31
Filing date: 2018-10-31
Publication date: 2021-05-04
Anticipated expiration: 2038-10-31
Also published as: CN109350351A

Abstract

The invention discloses a simple device for abdominal local thermal chemotherapy, which comprises a chemotherapy part and a connecting pipe, wherein the chemotherapy part and the connecting pipe are installed through a closed joint, the chemotherapy part comprises a permeable membrane layer, a bottom inner layer and a bottom outer layer, the bottom inner layer is positioned between the permeable membrane layer and the bottom outer layer, and an area between the permeable membrane layer and the bottom inner layer is used for storing medicines. In the invention, the designed chemotherapy part is provided with a permeable membrane layer, and can be accurately attached to the abdominal cavity for chemotherapy; a plurality of supporting pieces are designed to expand the chemotherapy part in a fan shape, and the chemotherapy part can be folded by folding each supporting piece, so that the chemotherapy part can be conveniently taken out of the abdominal cavity; the traction rod is designed, and the chemotherapy part can be unfolded or folded by pulling the traction rod. The invention has reasonable structure and convenient use, and can be widely applied to the technical field of medical instruments.

Description

Simple device for abdominal local thermal chemotherapy

Technical Field

The invention relates to the technical field of medical instruments, in particular to a simple device for abdominal local thermal chemotherapy.

Background

Peritoneal recurrence is easy to occur after abdominal tumor operation, the traditional treatment method is systemic chemotherapy through a venous system, but due to dose toxicity limitation and the existence of a peritoneal-plasma barrier, the concentration of the drug in the abdominal cavity is often low during systemic chemotherapy, and effective cytotoxicity effect on residual tumor cells and tumor metastasis in the abdominal cavity is difficult to achieve. The direct administration in the abdominal cavity can obviously increase the local drug concentration in the abdominal cavity, the area under the drug concentration-time curve (AUC) is obviously larger than that of the intravenous administration, and can reach tens of times to hundreds of times, thereby killing tumor cells to the maximum extent, reducing the toxic reaction caused by systemic intravenous chemotherapy and ensuring that the organism has better tolerance. In addition, the high temperature can play a synergistic anti-tumor role with the medicine, enhance the mobility of cancer cell membranes, increase the permeability of the cell membranes and blood vessels, accelerate the combination of cancer cells and the medicine, weaken the excretion capability of the medicine, further promote the penetration of the medicine to cancer tissues and deepen the infiltration depth of the medicine from 1-2mm to 5 mm. Studies have shown that normal cells can tolerate 47 ℃ for 1 hour, whereas tumor tissue is more sensitive than temperature and irreversible damage can occur only at 43 ℃ for 1 hour. Therefore, according to this principle, peritoneal metastasis of abdominal tumors has been prevented and treated by means of local thermal chemotherapy of the abdominal cavity. At present, the local chemotherapy mode of the abdominal cavity with a better treatment effect is mainly abdominal cavity hot perfusion chemotherapy (HIPEC), but when perfusion chemotherapy is carried out, a specific hot perfusion device needs to be started for perfusion, time and labor are wasted, the cost is high, and in clinical practice, the abdominal cavity hot perfusion chemotherapy (HIPEC) is only maintained for about one hour every time, and the medicine cannot be continuously released to a local focus for a long time. Moreover, the perfusion liquid fills the whole abdominal cavity, the treatment complications are more, and the effect of local chemotherapy of the abdominal cavity is reduced to a certain extent.

Disclosure of Invention

The invention aims to provide a simple device for abdominal local thermal chemotherapy, which can accurately position the abdominal local continuous thermal chemotherapy.

The technical scheme adopted for solving the technical problems is as follows:

the utility model provides a simple and easy device for abdominal cavity local thermal chemotherapy, includes chemotherapy portion and connecting pipe, installs through closed joint between chemotherapy portion and the connecting pipe, and chemotherapy portion is including penetrating the rete, end inlayer and end skin, and end inlayer is located and penetrates the rete and end between the skin, penetrates the region between rete and the end inlayer and is used for storing the medicine.

Furthermore, a plurality of supporting pieces are arranged between the bottom inner layer and the bottom outer layer, the chemotherapy part is unfolded in a fan shape by each supporting piece, a first hole is formed in one end of each supporting piece, a first shaft is arranged in the closed joint, and the first shaft sequentially penetrates through each first hole.

Furthermore, a traction rod is arranged in the connecting pipe, one end of the traction rod protrudes out of the tail end of the connecting pipe, and the other end of the traction rod is hinged with two supporting pieces positioned on the outer side in each supporting piece.

Further, the end of the traction rod is provided with a U-shaped structure which is used for being hinged with two corresponding supporting pieces, and two hinged pieces are arranged on the U-shaped structure.

Further, still include the heat conduction spare, the heat conduction spare includes heat conduction silk and a plurality of heater strip, and the heat conduction silk is arranged in the connecting pipe, and each heater strip is arranged in passing through the rete and the region between the inlayer at the bottom, and during the chemotherapy, each heater strip is fan-shaped distribution.

Has the advantages that: in the invention, the designed chemotherapy part is provided with a permeable membrane layer, and can be accurately attached to the abdominal cavity for chemotherapy; a plurality of supporting pieces are designed to expand the chemotherapy part in a fan shape, and the chemotherapy part can be folded by folding each supporting piece, so that the chemotherapy part can be conveniently taken out of the abdominal cavity; the traction rod is designed, and the chemotherapy part can be unfolded or folded by pulling the traction rod. The invention has reasonable structure and convenient use, and can be widely applied to the technical field of medical instruments.

Drawings

FIG. 1 is an overall plan view of the present invention;

FIG. 2 is a plan view of the bottom inner layer of the present invention, without showing the membrane-permeable layer and the drug;

FIG. 3 is a plan view of the bottom outer layer of the present invention, without showing the membrane-permeable layer and the bottom inner layer;

FIG. 4 is a view showing the construction of a closure joint of the present invention, not showing a connecting tube and a fixing clip;

FIG. 5 is a view showing the internal structure of the connecting tube of the present invention, without showing the chemotherapy part;

fig. 6 is a side view of the closed structure of the chemotherapeutic device of the present invention without the retaining clip, the membrane-permeable layer and the bottom inner layer.

Detailed Description

The present invention will be further described with reference to fig. 1 to 6.

A simple device for abdominal local thermal chemotherapy comprises a chemotherapy part and a connecting pipe 40, wherein the chemotherapy part and the connecting pipe 40 are installed through a closed joint 30. Chemotherapy portion includes and passes through rete 11, end inlayer 12 and end skin 13, and end inlayer 12 is located and passes through the rete 11 and end skin 13 between, passes through the region between rete 11 and the end inlayer 12 and is used for storing the medicine, and this region can be regarded as triangle-shaped medicine storage area, and the medicine of placing is solid state chemotherapy medicine, compares in liquid medicine, and the time that solid state chemotherapy medicine plays the effect is longer. In clinic, the permeable membrane layer 11 is attached to the abdominal wall, and the drug can be released at a certain rate through the permeable membrane layer 11, thereby continuously playing the role of chemotherapy.

The chemotherapy part is fixed in the abdominal cavity by a plurality of fixing clips 20, each fixing clip 20 is arranged at the edge of the chemotherapy part, and one fixing clip 20 is arranged at the installation position of the chemotherapy part and the connecting pipe 40.

In this embodiment, the heat conducting member further comprises a heat conducting wire 43 and a plurality of heating wires 44, the heat conducting wire 43 is disposed in the connecting pipe 40, one end of the heat conducting wire 43 is connected to an external heating device, and each heating wire 44 is disposed in the region between the membrane layer 11 and the bottom inner layer 12, and the chemotherapy part is maintained at a constant temperature, generally 43 ℃, by heating, thereby achieving the same thermal effect as the current clinical intraperitoneal perfusion chemotherapy (HIPEC) method.

A plurality of supporting pieces 14 are arranged between the bottom inner layer 12 and the bottom outer layer 13, the supporting pieces 14 are of soft plate structures, the chemotherapy part is unfolded in a fan shape by each supporting piece 14, a first hole is formed in one end of each supporting piece 14, and a first shaft is arranged in the closed joint 30 and sequentially penetrates through each first hole. A pulling rod 41 is arranged in the connecting pipe 40, one end of the pulling rod 41 protrudes from the end of the connecting pipe 40, the end of the pulling rod 41 can be used as an operating end, and the other end of the pulling rod 41 is hinged with two supporting pieces 14 which are positioned at the outer side in each supporting piece 14. By pulling the pulling rod 41, the support members 14 can be controlled to be unfolded or folded, so that the chemotherapy part can be unfolded or folded. After the chemotherapy is finished, the chemotherapy part is folded, and the chemotherapy part is taken out from the conventional postoperative drainage hole, so that the operation is convenient, and the injury to human tissues is small.

In this embodiment, the end of the pulling rod 41 is arranged with a U-shaped structure 42 for hinging with two corresponding supports 14, and two hinges are arranged on the U-shaped structure 42.

Correspondingly, in order to heat evenly, the heating wires 44 are distributed in a fan shape during chemotherapy, and after the chemotherapy part is folded, the heating wires 44 are folded accordingly.

While the embodiments of the present invention have been described in detail with reference to the drawings, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Claims

1. A simple device for abdominal cavity local thermal chemotherapy is characterized in that: including chemotherapy portion and connecting pipe, install through closed joint between chemotherapy portion and the connecting pipe, chemotherapy portion is including penetrating the rete, end inlayer and end skin, and end inlayer is located and penetrates between rete and the end skin, and the region between penetrating the rete and the end inlayer is used for storing the medicine, a plurality of support piece has been arranged between end inlayer and the end skin, and each support piece is fan-shaped expansion with chemotherapy portion, and the one end shaping of each support piece has first hole, has arranged the primary shaft in the closed joint, and the primary shaft passes each first hole in proper order, arranged the pull rod in the connecting pipe, the one end of pull rod is outstanding in the end of connecting pipe, and the other end of pull rod is articulated with two support pieces that lie in the outside in each.

2. The simple device for topical thermal chemotherapy of the abdominal cavity of claim 1, wherein: the end of the traction rod is provided with a U-shaped structure which is used for being hinged with two corresponding supporting pieces, and two hinged pieces are arranged on the U-shaped structure.

3. The simple device for topical thermal chemotherapy of the abdominal cavity of claim 1, wherein: still include the heat conduction spare, the heat conduction spare includes heat conduction silk and a plurality of heater strip, and the heat conduction silk is located the connecting pipe, and each heater strip is located the region between rete and the end inlayer of permeating, and during the chemotherapy, each heater strip is fan-shaped distribution.