CN109346145A - A kind of actively monitoring method and system of adverse drug reaction - Google Patents
A kind of actively monitoring method and system of adverse drug reaction Download PDFInfo
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- CN109346145A CN109346145A CN201811200585.6A CN201811200585A CN109346145A CN 109346145 A CN109346145 A CN 109346145A CN 201811200585 A CN201811200585 A CN 201811200585A CN 109346145 A CN109346145 A CN 109346145A
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
Abstract
The invention discloses a kind of actively monitoring method and systems of adverse drug reaction, by the kind and its drug specification that obtain drug to be monitored, and it is retrieved in doctor's advice administration data according to drug to be monitored, it will include that state of an illness data screening corresponding to drug to be monitored comes out in doctor's advice medication, then text Monitoring Rules are established for state of an illness data according to the adverse reaction description information of drug specification, utilize the suspect results in text Monitoring Rules monitoring state of an illness data with the presence or absence of generation adverse reaction, monitoring obtains patient may there is a situation where the sign of adverse reaction and doubtful generation adverse reactions during medication, while realizing the monitoring to drug, it is also possible that hospital can carry out targeted diagnosing and treating to patient in the follow-up process, it improves work efficiency.
Description
Technical field
The present invention relates to drug surveillance technical fields, more specifically to a kind of actively monitoring of adverse drug reaction
Method and system.
Background technique
Adverse drug reaction (Adverse Drug Reaction, abbreviation ADR) refers to by prescribed dose normal use medicine
Generated during product it is harmful rather than desired, have causal react with pharmaceutical applications.Adverse drug reaction is general
Side effect, four major class of toxic reaction, allergic reaction and secondary infection, in real life, the hair of adverse drug reaction can be divided into
Raw rate is high, and especially when drug or larger dosage is used for a long time, adverse drug reaction can endanger mankind's monitoring, and situation is tight
Even jeopardize the mankind's life when weight.Therefore detection adverse drug reaction rate to ensure drug safety, protect public health have meaning
Justice is great.
Currently, mainly carrying out the monitoring of adverse drug reaction using Hospital automatic monitoring system, monitoring process is specially pair
In regular hour (several months or several years) or certain range, such as in a certain hospital or a certain area, the use of drug with
And adverse reaction situation occurred makes detailed records, and then calculates corresponding adverse reaction rate, ultimately produces corresponding ADR report
It uploads.
However, existing Hospital automatic monitoring system is merely able to supervise the case for being diagnosed as occurring adverse reaction
It surveys and counts, and whether can not there is the sign that adverse reaction occurs to be monitored during medication to patient, be unfavorable for hospital
Subsequent diagnosing and treating is carried out to patient.
Summary of the invention
For above-mentioned existing Hospital automatic monitoring system be merely able to be diagnosed as occur adverse reaction case into
Row monitoring and statistics, and the defect that whether can not there is the sign that adverse reaction occurs to be monitored during medication to patient,
The present invention provides a kind of actively monitoring method and systems of adverse drug reaction.
In a first aspect, a kind of actively monitoring method of adverse drug reaction provided by the invention, comprising:
Obtain the kind and the corresponding drug specification of the drug to be monitored of drug to be monitored；
Adverse reaction description information in the drug specification is extracted, text Monitoring Rules are obtained；
Doctor's advice administration data is retrieved according to the kind of the drug to be monitored, acquisition includes the medicine to be monitored
First doctor's advice administration data of object；
It is retrieved according to the text Monitoring Rules pair state of an illness data associated with the first doctor's advice administration data
It compares, monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
Optionally, the adverse reaction description information in the drug specification extracts, and obtains text monitoring
Rule includes:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information
Text matches are carried out with adverse reaction terminology bank, obtain symptom text Monitoring Rules.
Optionally, described according to the text Monitoring Rules pair state of an illness number associated with the first doctor's advice administration data
According to carrying out retrieval comparison, monitoring, which obtains, to be met the monitoring data results of the text Monitoring Rules and includes:
It retrieves and compares the non-structured text in electronic health record data associated with the first doctor's advice administration data
Whether include symptom terms or the symptom terms in the symptom text Monitoring Rules synonym, if so, will deposit
In the electronic health record data of the symptom terms or the synonym of the symptom terms as the first monitoring data result；
The state of an illness data include electronic health record data.
Optionally, the adverse reaction description information in the drug specification extracts, and obtains text monitoring
Rule further include:
It is positioned in the adverse reaction description information with the matched index word of the test rating terminology bank, and
Interception includes the sentence of the index word, extracts the variation degree word in the sentence, establishes the variation degree word and institute
The corresponding relationship between index word is stated, test rating Monitoring Rules are obtained；
It is carried out according to the test rating Monitoring Rules pair inspection data associated with the first doctor's advice administration data
Retrieval compares, and obtains the second monitoring data result for meeting the test rating Monitoring Rules；
The state of an illness data include inspection data.
Optionally, the adverse reaction description information in the drug specification extracts, and obtains text monitoring
Rule further include:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information
Text matches are carried out with medicine terms library, obtain feature drug surveillance rule；
Retrieval comparison is carried out to the first doctor's advice administration data according to the feature drug surveillance rule, acquisition meets institute
State the third monitoring data result of feature drug surveillance rule.
Optionally, further includes: the first monitoring data result, the second prison are obtained according to the adverse reaction description information respectively
The frequency of occurrences of measured data result and third monitoring data result, and first monitoring data are assigned according to the frequency of occurrences
As a result, the second monitoring data result and the corresponding weighted value of the third monitoring data；
The first monitoring data result, the second monitoring data result corresponding to state of an illness data by same patient
It is overlapped with the weighted value of the third monitoring data, obtains weight total value；
By the size order of weight total value in the state of an illness data of all patients, display is ranked up to patient data.
Optionally, further includes: monitoring time and/or monitoring department's range and/or Monitoring Population range are obtained, according to described
Monitoring time and/or monitoring department's range and/or the Monitoring Population range screen the state of an illness data, obtain
State of an illness data after screening；
According to the kind pair of the drug to be monitored doctor's advice administration data associated with the state of an illness data after the screening
It is retrieved, acquisition includes the first doctor's advice administration data of the drug to be monitored.
Optionally, the kind for obtaining drug to be monitored includes:
The high-risk grade types of drugs of hospital's calibration is retrieved and obtained in hospital information system or in default website system
The drug research kind of drug safety monitoring project is retrieved and obtained in system.
Optionally, further includes:
Combination Monitoring Rules are configured according to corresponding combination condition by a variety of search conditions according to configuration-direct；
Matching retrieval is carried out to the state of an illness data in information for hospital database according to the combination Monitoring Rules, is retrieved
Result set；
Wherein, a variety of search conditions include patient's retrieval, examine retrieval, doctor's advice retrieval, case history retrieval, diagnosis inspection
Rope, sign retrieval and inspection retrieval；
The combination condition include with or it is non-.
Second aspect, a kind of actively monitoring system of adverse drug reaction provided by the invention, comprising:
Module is obtained, for obtaining the kind and the corresponding drug specification of the drug to be monitored of drug to be monitored；
Rulemaking module obtains text for extracting to the adverse reaction description information in the drug specification
This Monitoring Rules；
Retrieval module included for being retrieved according to the kind of the drug to be monitored to doctor's advice administration data
There is the first doctor's advice administration data of the drug to be monitored；
Monitoring modular, for according to the text Monitoring Rules pair state of an illness associated with the first doctor's advice administration data
Data carry out retrieval comparison, and monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
The invention has the following advantages:
By obtaining the kind and its drug specification of drug to be monitored in the present invention, and according to drug to be monitored in doctor's advice
It is retrieved in administration data, will include that state of an illness data screening corresponding to drug to be monitored comes out in doctor's advice medication, then basis
The adverse reaction description information of drug specification establishes text Monitoring Rules for state of an illness data, is monitored using text Monitoring Rules
With the presence or absence of the suspect results that adverse reaction occurs in state of an illness data, monitoring acquisition patient may occur bad during medication
The sign of reaction and doubtful there is a situation where adverse reaction, while realizing the monitoring to drug, it is also possible that hospital
Targeted diagnosing and treating can be carried out to patient in the follow-up process, improved work efficiency.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples, in attached drawing:
Fig. 1 is a kind of flow diagram of the actively monitoring method of adverse drug reaction provided in an embodiment of the present invention；
Fig. 2 is a kind of structural schematic diagram of data acquisition interface provided in an embodiment of the present invention；
Fig. 3 is a kind of another process signal of actively monitoring method of adverse drug reaction provided in an embodiment of the present invention
Figure；
Fig. 4 is a kind of schematic diagram that Monitoring Rules are extracted based on adverse reaction description information provided in an embodiment of the present invention；
Fig. 5 is a kind of adverse Drug Reaction Monitoring process signal based on custom rule provided in an embodiment of the present invention
Figure；
Fig. 6 is a kind of structural schematic diagram of the actively monitoring system of adverse drug reaction provided in an embodiment of the present invention.
Specific embodiment
For a clearer understanding of the technical characteristics, objects and effects of the present invention, now control attached drawing is described in detail
A specific embodiment of the invention.
As shown in FIG. 1, FIG. 1 is a kind of processes of the actively monitoring method of adverse drug reaction provided in an embodiment of the present invention
Schematic diagram, a kind of actively monitoring method of adverse drug reaction provided in an embodiment of the present invention, comprising:
S101, the kind and the corresponding drug specification of the drug to be monitored for obtaining drug to be monitored；
It is understood that some discoveries after using are easy to happen adverse reaction or generation adverse reaction consequence is more tight
The drug of weight would generally be demarcated as the types of drugs of high-risk grade by hospital；In addition, after the listing of some new drugs, in order to guarantee
Unknown influence brought by new drug can obtain control, usually also some drugs can be included in drug safety monitoring project
Drug is monitored.It therefore, in embodiments of the present invention, can be in order to get types of drugs to be monitored automatically in real time
By the way that the high-risk grade types of drugs of hospital's calibration is retrieved and obtained in hospital information system or in default web station system
The drug research kind of drug safety monitoring project is retrieved and obtains, to obtain the types of drugs of pending monitoring.Wherein, in advance
If website can have the website of the drug research kind of drug safety monitoring project for the record inputted by medical worker.It is logical
It crosses setting periodically to be retrieved in hospital information system or default web station system automatically, types of drugs to be monitored may be implemented
With hospital information system and drug safety monitoring project real-time update, to guarantee the comprehensive monitoring to drug.In addition, wait supervise
The kind for surveying drug can also be determined by staff according to the real process of hospital treatment patient.
Simultaneously as every kind of drug has corresponding drug specification, therefore, the kind for getting drug to be monitored it
Afterwards, it can directly be retrieved in the databases such as national drug library according to the variety name of drug to be monitored and get corresponding drug
Specification.
S102, the adverse reaction description information in the drug specification is extracted, obtains text Monitoring Rules；
Due in addition to recording adverse reaction description information, usually can also be recorded in drug specification drug the name of an article,
Specification, validity period, main component, indication or major function, usage, dosage, taboo and points for attention etc., therefore, Ke Yitong
Character recognition technology is crossed to extract the adverse reaction description information in package insert.Due in adverse reaction description information
The information such as some symptoms for occurring adverse reaction or index variation would generally be recorded, therefore, in the drug specification
After adverse reaction description information extracts, will can specifically it be retouched in adverse reaction description information or adverse reaction description information
The text Monitoring Rules that information is monitored as text retrieval are stated, to be monitored to subsequent state of an illness data.
S103, doctor's advice administration data is retrieved according to the kind of the drug to be monitored, acquisition include it is described to
Monitor the first doctor's advice administration data of drug；
It should be noted that information database has been typically set up in hospital in order to record and store the medical treatment situation of patient,
For storing the state of an illness data of the medical treatment process of patient in real time.However, stored by the information database that different hospitals is established
The format of data may carry out adverse drug reaction in order to subsequent to be inconsistent, in order to obtain the data of unified format
Monitoring, needs to establish unified data exchange interface.As shown in Fig. 2, Fig. 2 is a kind of data acquisition provided in an embodiment of the present invention
The structural schematic diagram of interface, wherein data acquisition interface can respectively with ADR Centralizing inspection database, hospital information system
(Hospital Information System, HIS), electronic medical record system (Electronic Medical Record,
EMR), the systems such as clinical laboratory's information system (Laboratory Information System, LIS) connect, and are not influencing hospital
Related system operate normally in the case where, realize and the acquisition of related system data and calling handled.Wherein, the present invention is real
Applying the state of an illness data mentioned in example includes the basic condition data of patient, medical treatment data etc., and doctor's advice administration data is then patient
Medicining condition data during medical treatment.
It is understood that will can first take the drug to be monitored to monitor the adverse reaction situation of drug
Patient screens, and is monitored in the follow-up process to the state of an illness data for the patient for having taken drug to be monitored.Wherein, by
It is a kind of structured database in hospital information system, and doctor's advice administration data is a kind of knot stored in hospital information system
Therefore structure data can be used with quick-searching to corresponding doctor's advice administration data by retrieval doctor's advice in hospital information system
Whether include drug to be monitored in medicine data, can quickly screen the first doctor's advice that acquisition includes the drug to be monitored and use
Medicine data.
S105, it is carried out according to the text Monitoring Rules pair state of an illness data associated with the first doctor's advice administration data
Retrieval compares, and monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
Finally, being monitored by Monitoring Rules to the state of an illness data for the patient for taking drug to be monitored, can obtain
Meet the patient monitoring data of Monitoring Rules.Patient monitoring data obtained can be submitted into clinical pharmacist or doctor carries out
Analysis review, to judge whether patient occurs adverse reaction or with the presence or absence of the sign of adverse reaction, if patient occur it is bad anti-
It answers, then can directly generate ADR account, complete reporting for ADR report；If patient, can be with there are the sign of adverse reaction
The successive treatment process of patient is adjusted according to the actual situation.The adverse drug reaction provided through the embodiment of the present invention
Actively monitoring method can quickly monitor the doubtful case that adverse reaction occurs, and when being determined as adverse drug reaction, fastly
Fast-growing is reported at ADR and is uploaded；When being determined as adverse drug reaction sign, subsequent therapeutic process, this hair can be effectively instructed
In bright embodiment while realizing to adverse Drug Reaction Monitoring, additionally it is possible to the suspicious adverse reaction disease for not being diagnosed to be doctor
Feelings carry out early warning, and doctor's subsequent diagnoses and treatment process is additionally aided while improving monitoring efficiency.
Specifically, in a kind of embodiment provided in an embodiment of the present invention, it is described in the drug specification not
Good reaction description information extracts, and obtaining text Monitoring Rules can specifically include:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information
Text matches are carried out with adverse reaction terminology bank, obtain symptom text Monitoring Rules.
It is understood that since the adverse reaction being accordingly likely to occur would generally be recorded in adverse reaction description information
Symptom, as long as therefore by adverse reaction description information with include all adverse reaction symptom terms adverse reaction terminology bank
Text matches are carried out, adverse reaction symptom included in adverse reaction description information can be obtained.According to adverse reaction term
Adverse reaction symptom that matching obtains can be arranged as adverse reaction symptom set by the format of rule set, finally that this is bad instead
Answering sympotomatic set cooperation is that symptom text Monitoring Rules compare to carry out the retrieval to state of an illness data, and acquisition includes adverse reaction disease
The state of an illness data of shape set, the state of an illness data and associated patient data are used as the first monitoring data result.
Wherein, according to symptom rule to state of an illness data carry out retrieval compare when, can specifically retrieve and compare with it is described
Whether the non-structured text in the associated electronic health record data of the first doctor's advice administration data includes the symptom text prison
Gauge then in symptom terms or the symptom terms synonym, if so, the symptom terms or the symptom will be present
The electronic health record data of the synonym of term are as the first monitoring data result.
It is understood that electronic health record data can be obtained from hospital information system, the first doctor's advice is obtained in screening
After administration data, corresponding electronic health record is found according to the ID of patient in the first doctor's advice administration data, that is, is found and the first doctor's advice
The relevant electronic health record data of administration data.Due to including patient in electronic health record in the original of hospital diagnosis treatment overall process
Record, and the symptom recorded after doctor diagnoses patient would generally be recorded in the non-structured text of electronic health record
Therefore description carries out the symptom terms or the symptom in symptom text Monitoring Rules to the non-structured text of electronic health record
The retrieval of the synonym of term, can be with quick obtaining to taking the disease for generating corresponding adverse reaction symptom after the drug to be monitored
Personal data.
In order to make it easy to understand, being analyzed below with reference to specific application scenarios.For example, the specification of drug to be monitored
In adverse reaction description information be specially that " the most common adverse reaction of this product is symptom 1, other there are also symptoms 2, symptom 3, disease
Shape 4 and symptom 5.", after the adverse reaction description information and adverse reaction terminology bank are carried out text matches, it can obtain pair
The symptom text Monitoring Rules " symptom set: symptom 1, symptom 2, symptom 3, symptom 4, symptom 5 " answered.Then, it is cured with first
Advise the relevant electronic health record data of administration data non-structured text search for symptom set in " symptom 1, symptom 2, symptom 3,
The synonym or near synonym of symptom 4, symptom 5 " and symptom set.If in the non-structural culture of electronic health record data, there are symptoms
One of set or a variety of symptoms, such as " patient since medical, upon examination it is found that symptom 1, and once in a while with symptom 2
Appearance ", which can be extracted, and as monitoring data result；By to all electronic health records
Non-structural text carries out retrieval comparison, can obtain all patient datas for meeting symptom text Monitoring Rules, that is, be owned
Monitoring data result.
Specifically, described in the drug specification in another embodiment provided in an embodiment of the present invention
Adverse reaction description information extracts, and obtaining text Monitoring Rules can also include:
It is positioned in the adverse reaction description information with the matched index word of the test rating terminology bank, and
Interception includes the sentence of the index word, extracts the variation degree word in the sentence, establishes the variation degree word and institute
The corresponding relationship between index word is stated, test rating Monitoring Rules are obtained；According to the test rating Monitoring Rules pair and institute
It states the first associated inspection data of doctor's advice administration data and carries out retrieval comparison, acquisition meets the test rating Monitoring Rules
Second monitoring data result；
Wherein, inspection data can be by calling the data of clinical laboratory's information system to obtain.It is understood that due to not
In good reaction description information other than the description of symptom, it is also possible to will include the description of corresponding test rating, such as " this product
Adverse reaction be that even test rating 1 and test rating 2 can be caused to increase." and hence it is also possible to compare the inspection of patient by retrieval
The variation of test rating in data is tested to monitor whether patient occurs adverse reaction.In addition, it is necessary to explanation, due to needing to examine
Therefore rope test rating and the retrieval corresponding variation degree of index when formulating test rating Monitoring Rules, need first to find
Test rating in adverse reaction description information is simultaneously located, since the variation degree word of test rating would generally refer to inspection
Mark will carry out in same sentence, therefore after navigating to test rating word comprising the sentence of the test rating word
Interception, and the variation degree word in sentence can be extracted according to variation degree dictionary, foundation obtains test rating and variation
Corresponding relationship between degree.For example, " adverse reaction of this product is that test rating 1 and test rating 2 can occasionally be caused to increase."
In, " test rating 1 ", " test rating 1 " can be first navigated to, then variation degree word " liter is extracted in matching in the sentence
It is high ", therefore, it can establish test rating Monitoring Rules: " raising of test rating 1 ", " raising of test rating 2 ".Finally, according to obtaining
The test rating Monitoring Rules obtained carry out retrieval comparison to inspection data, can obtain and meet the test rating Monitoring Rules
Second monitoring data result.
In addition, monitoring rule in addition to can establish the corresponding relationship between test rating and variation degree word as test rating
Then, it can also include specific index value or index value range in the sentence of test rating word by extracting, and will examine
Index and index value are as test rating Monitoring Rules.For example, establishing test rating Monitoring Rules are as follows: " test rating 3 is
1.2%~2.2% ".
In another embodiment provided in an embodiment of the present invention, the adverse reaction in the drug specification
Description information extracts, and obtains text Monitoring Rules further include:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information
Text matches are carried out with medicine terms library, obtain feature drug surveillance rule；According to the feature drug surveillance rule to described
First doctor's advice administration data carries out retrieval comparison, obtains the third monitoring data result for meeting the feature drug surveillance rule.
It is understood that may also contain in adverse reaction description information corresponding for slowing down adverse reaction
Therefore feature drug is compared in the doctor's advice medication of patient whether have feature drug by retrieval, can equally monitor disease
Whether people, which has, occurs adverse reaction or the sign there are adverse reaction.For example, in adverse reaction description information: " can occasionally cause to examine
It tests index 1 and test rating 2 increases.Therefore liver function need to be monitored, the protecting liver, lowering enzymes medicines such as drug 1, drug 2, drug 3 can be used.",
The adverse reaction description information and medicine terms library are subjected to text matches according to preset feature drug rule set, can be obtained
Feature drug surveillance rule: " drug 1, drug 2, drug 3 ".Finally, comparing the further according to this feature drug surveillance rule search
Whether include " drug 1, drug 2, drug 3 " in one doctor's advice administration data, and will include above-mentioned " drug 1, drug 2, drug
3 " the first doctor's advice administration data and its corresponding patient data are as third monitoring data result.
It should be noted that can individually use it in three kinds of above-mentioned embodiments provided in an embodiment of the present invention
A kind of middle embodiment realizes the monitoring to adverse reaction, using two or three of embodiment and can also seek supervising simultaneously
The intersection of measured data result or union obtain new monitoring data result to realize the monitoring to adverse reaction.It is noticeable
It is that, when seeking the intersection of monitoring data simultaneously using numerous embodiments, can first seek the second monitoring data result or the
Three monitoring data as a result, the first monitoring data are sought based on the second monitoring data result or third monitoring data result again as a result,
In order to reduce operand, arithmetic speed is improved.Since the test rating in the second monitoring data outcome procedure is as structure
Change data to be present in inspection data, seeking the feature drug in third monitoring data result is also to exist as structural data
In doctor's advice administration data, and symptom word is to be present in non-structured text in electronic health record data, therefore, according to text
The test operand that compares of retrieval of data or doctor's advice administration data of Monitoring Rules is less than and carries out electronic health record data
The retrieval of non-structured text compare, i.e., arithmetic speed will be significantly better than the non-structured text for carrying out electronic health record data
Retrieval compares.As shown in figure 3, Fig. 3 is a kind of the another of actively monitoring method of adverse drug reaction provided in an embodiment of the present invention
One flow diagram.
It is understood that monitoring data result can when the data volume for the monitoring data result that monitoring obtains is huger
There can be a large amount of suspicious higher adverse reaction monitoring data of degree, while there is also a large amount of suspicious lower adverse reaction prisons of degree
Measured data.Therefore, quickly preferentially the suspicious higher adverse reaction monitoring data of degree are carried out for the ease of clinical pharmacist or doctor
Processing, can be ranked up all monitoring data results.
It specifically, can be that a kind of adverse reaction description information that is based on provided in an embodiment of the present invention is mentioned refering to Fig. 4, Fig. 4
Take the schematic diagram of Monitoring Rules.It is understood that can describe to believe according to adverse reaction when generating corresponding Monitoring Rules
It is corresponding that Monitoring Rules and its frequency of occurrences are carried out hook by frequency word in breath, is obtaining the first monitoring data result, second
After monitoring data result and third monitoring data result, while the frequency of occurrences of above-mentioned monitoring data result can be obtained, and
The first monitoring data result, the second monitoring data result and the third, which are assigned, according to the frequency of occurrences monitors number
According to corresponding weighted value.For example, the frequency word in adverse reaction description information includes " common, once in a while, rare ", then can divide
Not Fu Yu " 0.7,0.25,0.05 " weighted value.By the corresponding first monitoring data result of same patient data, described
The weighted value of three monitoring data results and the 4th monitoring data is overlapped, and can obtain weight total value；Finally by all
Patient data in weight total value size order, display is ranked up to patient data.For example, patient data is specially " out
Existing symptom 1 and symptom 2, at the same also with test rating 1 increase and doctor's advice medication in include drug 1 and drug 2 ", then it is sick
The weight total value of personal data is " 0.7+0.7+0.25+0.25+0.25=2.15 "；Patient data be specially " there is symptom 6, and
Increased with test rating 3 ", then the weight total value of patient data is " 0.05+0.05=0.1 ".
In addition, in embodiments of the present invention can also include: to obtain monitoring time and/or monitoring department's range and/or prison
Survey crowd's range, according to the monitoring time and/or monitoring department's range and/or the Monitoring Population range to the disease
Feelings data are screened, the state of an illness data after being screened；
According to the kind pair of the drug to be monitored doctor's advice administration data associated with the state of an illness data after the screening
It is retrieved, acquisition includes the first doctor's advice administration data of the drug to be monitored.
It is understood that since drug generally can all have certain scope of application, and be not that all patients can
It uses, i.e., therefore drug is carrying out the prison to drug to be monitored for certain some specific symptom or specific crowd's range
Before survey, the state of an illness data that drug to be monitored is applicable in can be screened in advance, to reduce monitoring data amount, improve arithmetic speed.
For example, just listed trimestral " antihypertensive " for certain class, can according to " in three months ", " internal medicine department ", " 35 years old with
The screening conditions of upper patient " in advance screen state of an illness data.
It is possible to further which refering to Fig. 5, Fig. 5 is a kind of drug based on custom rule provided in an embodiment of the present invention
Adverse reaction monitoring flow diagram.Monitoring in addition to carrying out drug according to adverse reaction description information in drug specification, also
Corresponding customized Monitoring Rules can be formulated according to the actual conditions of drug to realize to drug by clinical pharmacist or doctor etc.
Actively monitoring, can also include: in the embodiment of the present invention
Combination Monitoring Rules are configured according to corresponding combination condition by a variety of search conditions according to configuration-direct；
Matching retrieval is carried out to the state of an illness data in information for hospital database according to the combination Monitoring Rules, is retrieved
Result set；
Wherein, a variety of search conditions include patient's retrieval, examine retrieval, doctor's advice retrieval, case history retrieval, diagnosis inspection
Rope, sign retrieval and inspection retrieval；
Patient's search condition, comprising: name, discharge department, admission number, gender, the age, admission time, goes out at department of being admitted to hospital
Institute's time；
Examine search condition, comprising: examine project, test value, submission date；
Doctor's advice search condition, comprising: drug, dosage, search terms, administration time, withdrawal time；
Case history search condition, comprising: record time, course of disease type, ADR classification, ADR title；
Diagnostic search condition, comprising: diagnosis name, Diagnostic Time；
Sign search condition, comprising: sign project, sign value, time of measuring；
Check search condition, comprising: check that diagnostic comments, check data, inspection result (qualitative), inspection result are (fixed
Amount), check image, inspection item, inspection method, check point, inspect-type；
The combination condition between search condition include with or non-logical relation, meanwhile, individually retrieval item
Project under part includes relationships such as " include, do not include, being equal to, being not equal to ".As shown in table 1, table 1 is search condition logic pass
System's figure:
1 search condition logic relation picture of table
After obtaining retrieval set, can by the degree of correlation height display is ranked up to retrieval set, then by
Clinical pharmacist or doctor audit retrieval set, and generate corresponding ADR report.
It can be a kind of knot of the actively monitoring system of adverse drug reaction provided in an embodiment of the present invention refering to Fig. 6, Fig. 6
Structure schematic diagram.Second aspect, the embodiment of the invention also provides a kind of actively monitoring systems of adverse drug reaction, comprising:
Module 601 is obtained, for obtaining the kind and the corresponding drug specification of the drug to be monitored of drug to be monitored；
Rulemaking module 602 is obtained for extracting to the adverse reaction description information in the drug specification
Text Monitoring Rules；
Retrieval module 603 is wrapped for being retrieved according to the kind of the drug to be monitored to doctor's advice administration data
The first doctor's advice administration data containing the drug to be monitored；
Monitoring modular 604, for associated with the first doctor's advice administration data according to the text Monitoring Rules pair
State of an illness data carry out retrieval comparison, and monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
In the embodiment of the present invention, monitoring modular 604 includes the first monitoring unit, and the first monitoring unit is used for the drug
Adverse reaction description information in specification extracts, and by the adverse reaction description information and adverse reaction terminology bank into
Row text matches obtain symptom text Monitoring Rules.
In the embodiment of the present invention, the first monitoring unit is specifically also used to retrieve and compare and the first doctor's advice administration data
Whether non-structured text in associated electronic health record data includes symptom art in the symptom text Monitoring Rules
The synonym of language or the symptom terms, if so, the electricity of the synonym of the symptom terms or the symptom terms will be present
Sub- medical record data is as the first monitoring data result；The state of an illness data include electronic health record data.
In the embodiment of the present invention, monitoring modular 604 further includes the second monitoring unit, the second monitoring unit be used for it is described not
It is positioned in good reaction description information with the matched index word of the test rating terminology bank, and intercepting includes the index
The sentence of word extracts the variation degree word in the sentence, establishes between the variation degree word and the index word
Corresponding relationship obtains test rating Monitoring Rules；
It is carried out according to the test rating Monitoring Rules pair inspection data associated with the first doctor's advice administration data
Retrieval compares, and obtains the second monitoring data result for meeting the test rating Monitoring Rules；The state of an illness data include examining
Data.
In the embodiment of the present invention, monitoring modular 604 further includes third monitoring unit, and third monitoring unit is used for the medicine
Adverse reaction description information in object specification extracts, and the adverse reaction description information and medicine terms library are carried out
Text matches obtain feature drug surveillance rule；
Retrieval comparison is carried out to the first doctor's advice administration data according to the feature drug surveillance rule, acquisition meets institute
State the third monitoring data result of feature drug surveillance rule.
In the embodiment of the present invention, further includes: weighted value seeks module, the weighted value seek module for according to described in not
Good reaction description information obtains going out for the first monitoring data result, the second monitoring data result and third monitoring data result respectively
Existing frequency, and the first monitoring data result, the second monitoring data result and described are assigned according to the frequency of occurrences
The corresponding weighted value of third monitoring data；The first monitoring data result, institute corresponding to state of an illness data by same patient
The weighted value for stating the second monitoring data result and the third monitoring data is overlapped, and obtains weight total value；By all patients
State of an illness data in weight total value size order, display is ranked up to patient data.
In the embodiment of the present invention, further includes: screening module, the screening module is for obtaining monitoring time and/or monitoring
Department's range and/or Monitoring Population range, according to the monitoring time and/or monitoring department's range and/or the monitoring
Crowd's range screens the state of an illness data, the state of an illness data after being screened；According to the kind of the drug to be monitored
Doctor's advice administration data associated with the state of an illness data after the screening is retrieved, acquisition includes the drug to be monitored
The first doctor's advice administration data.
In the embodiment of the present invention, obtains module 601 and be specifically used for that hospital's calibration is retrieved and obtained in hospital information system
High-risk grade types of drugs or retrieve and obtain the drug research of drug safety monitoring project in default web station system
Kind.
In the embodiment of the present invention, further includes: combination monitoring modular, the combination monitoring modular is used for will according to configuration-direct
A variety of search conditions are configured to combination Monitoring Rules according to corresponding combination condition；Hospital is believed according to the combination Monitoring Rules
State of an illness data in breath database carry out matching retrieval, obtain retrieval set；Wherein, a variety of search conditions include patient
Retrieval examines retrieval, doctor's advice retrieval, case history retrieval, diagnostic search, sign retrieval and checks retrieval；The combination condition includes
With or it is non-.
Adverse drug reaction provided by the embodiment of the present invention can be performed in the actively monitoring system of said medicine adverse reaction
Actively monitoring method, have the corresponding functional module of execution method and beneficial effect.It is held as wherein each functional module
Capable processing method can refer to the description in above method embodiment, no longer be repeated herein.
Those of ordinary skill in the art will appreciate that realizing all or part of the process in above-described embodiment method, being can be with
Relevant hardware is instructed to complete by computer program, the program can be stored in a computer-readable storage medium
In, the program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein, the storage medium can be magnetic
Dish, CD, read-only memory (Read-OnlyMemory, ROM) or random access memory
(RandomAccessMemory, RAM) etc..
Above-mentioned computer readable storage medium is for storing adverse Drug Reaction Monitoring side provided by the embodiment of the present invention
The program (instruction) of method, wherein adverse Drug Reaction Monitoring side provided by the embodiment of the present invention can be executed by executing the program
Method has the corresponding beneficial effect of execution method.It can refer to the description in above method embodiment, no longer repeated herein.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, protection scope of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of actively monitoring method of adverse drug reaction characterized by comprising
Obtain the kind and the corresponding drug specification of the drug to be monitored of drug to be monitored；
Adverse reaction description information in the drug specification is extracted, text Monitoring Rules are obtained；
Doctor's advice administration data is retrieved according to the kind of the drug to be monitored, acquisition includes the drug to be monitored
First doctor's advice administration data；
Retrieval is carried out according to the text Monitoring Rules pair state of an illness data associated with the first doctor's advice administration data to compare,
Monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
2. the actively monitoring method of adverse drug reaction according to claim 1, which is characterized in that described to the drug
Adverse reaction description information in specification extracts, and obtains text Monitoring Rules and includes:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information and not
Good reaction terminology bank carries out text matches, obtains symptom text Monitoring Rules.
3. the actively monitoring method of adverse drug reaction according to claim 2, which is characterized in that described according to the text
This Monitoring Rules pair state of an illness data associated with the first doctor's advice administration data carry out retrieval and compare, and monitoring, which obtains, meets institute
The monitoring data result for stating text Monitoring Rules includes:
It retrieves and whether compares the non-structured text in electronic health record data associated with the first doctor's advice administration data
It include the synonym of the symptom terms or the symptom terms in the symptom text Monitoring Rules, if so, institute will be present
The electronic health record data of the synonym of symptom terms or the symptom terms are stated as the first monitoring data result；
The state of an illness data include electronic health record data.
4. the actively monitoring method of adverse drug reaction according to claim 3, which is characterized in that described to the drug
Adverse reaction description information in specification extracts, and obtains text Monitoring Rules further include:
It positions, and intercepts with the matched index word of the test rating terminology bank in the adverse reaction description information
Sentence comprising the index word extracts the variation degree word in the sentence, establishes the variation degree word and the finger
The corresponding relationship between word is marked, test rating Monitoring Rules are obtained；
It is retrieved according to the test rating Monitoring Rules pair inspection data associated with the first doctor's advice administration data
It compares, obtains the second monitoring data result for meeting the test rating Monitoring Rules；
The state of an illness data include inspection data.
5. the actively monitoring method of adverse drug reaction according to claim 4, which is characterized in that described to the drug
Adverse reaction description information in specification extracts, and obtains text Monitoring Rules further include:
Adverse reaction description information in the drug specification is extracted, and by the adverse reaction description information and medicine
Object terminology bank carries out text matches, obtains feature drug surveillance rule；
Retrieval comparison is carried out to the first doctor's advice administration data according to the feature drug surveillance rule, acquisition meets the spy
Levy the third monitoring data result of drug surveillance rule.
6. the actively monitoring method of adverse drug reaction according to claim 5, which is characterized in that further include:
The first monitoring data result, the second monitoring data result and third prison are obtained respectively according to the adverse reaction description information
The frequency of occurrences of measured data result, and the first monitoring data result, second monitoring are assigned according to the frequency of occurrences
Data result and the corresponding weighted value of the third monitoring data；
The first monitoring data result, the second monitoring data result and institute corresponding to state of an illness data by same patient
The weighted value for stating third monitoring data is overlapped, and obtains weight total value；
By the size order of weight total value in the state of an illness data of all patients, display is ranked up to patient data.
7. the actively monitoring method of adverse drug reaction according to claim 1, which is characterized in that further include:
Monitoring time and/or monitoring department's range and/or Monitoring Population range are obtained, according to the monitoring time and/or described
Monitoring department's range and/or the Monitoring Population range screen the state of an illness data, the state of an illness data after being screened；
It is carried out according to the kind pair of the drug to be monitored doctor's advice administration data associated with the state of an illness data after the screening
Retrieval, acquisition includes the first doctor's advice administration data of the drug to be monitored.
8. the actively monitoring method of adverse drug reaction according to claim 1, which is characterized in that the acquisition is to be monitored
The kind of drug includes:
The high-risk grade types of drugs of hospital's calibration is retrieved and obtained in hospital information system or in default web station system
Retrieve and obtain the drug research kind of drug safety monitoring project.
9. the actively monitoring method of adverse drug reaction according to claim 1, which is characterized in that further include:
Combination Monitoring Rules are configured according to corresponding combination condition by a variety of search conditions according to configuration-direct；
Matching retrieval is carried out to the state of an illness data in information for hospital database according to the combination Monitoring Rules, obtains search result
Collection；
Wherein, a variety of search conditions include patient's retrieval, examine retrieval, doctor's advice retrieval, case history retrieval, diagnostic search, body
Sign retrieval and inspection retrieval；
The combination condition include with or it is non-.
10. a kind of actively monitoring system of adverse drug reaction characterized by comprising
Module is obtained, for obtaining the kind and the corresponding drug specification of the drug to be monitored of drug to be monitored；
Rulemaking module obtains text prison for extracting to the adverse reaction description information in the drug specification
Gauge is then；
Retrieval module is obtained for being retrieved according to the kind of the drug to be monitored to doctor's advice administration data comprising
State the first doctor's advice administration data of drug to be monitored；
Monitoring modular, for according to the text Monitoring Rules pair state of an illness data associated with the first doctor's advice administration data
Retrieval comparison is carried out, monitoring obtains the monitoring data result for meeting the text Monitoring Rules.
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| CN111161891A (en) * | 2019-12-31 | 2020-05-15 | 重庆亚德科技股份有限公司 | Traditional Chinese medicine information management platform |
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| CN111681777A (en) * | 2020-06-05 | 2020-09-18 | 河南省药品评价中心 | Early warning method of potential addiction-causing hallucinogenic drugs based on medical history information |
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| CN114582459A (en) * | 2022-01-27 | 2022-06-03 | 中南大学湘雅三医院 | Information processing method, device and equipment based on diagnosis and treatment data and storage medium |
| CN115312205A (en) * | 2022-10-11 | 2022-11-08 | 四川省医学科学院·四川省人民医院 | Single-disease clinical path management system |
| CN117133476A (en) * | 2023-07-24 | 2023-11-28 | 盐城市食品药品监督检验中心 | Active monitoring method and system for adverse drug reaction |
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| CN116798654A (en) * | 2023-08-24 | 2023-09-22 | 西藏自治区人民政府驻成都办事处医院 | Method and system for actively monitoring adverse reactions of old inpatients |
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