CN109320464A - A kind of purification process of small grain size ambrisentan - Google Patents
A kind of purification process of small grain size ambrisentan Download PDFInfo
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- CN109320464A CN109320464A CN201811164803.5A CN201811164803A CN109320464A CN 109320464 A CN109320464 A CN 109320464A CN 201811164803 A CN201811164803 A CN 201811164803A CN 109320464 A CN109320464 A CN 109320464A
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- ambrisentan
- grain size
- small grain
- ethanol water
- purification process
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of purification process of small grain size ambrisentan, belong to bulk pharmaceutical chemicals preparation technical field.Technical solution of the present invention is: ambrisentan crude product being dissolved in ethyl acetate first, is then cooled to -5 to 5 DEG C, stirring flows down plus the 50-60% ethanol water of 1.5-3 times of first step solvent volume；Mixing speed is 230-270 revs/min, and the speed of stream plus ethanol water is 8-15ml/ points, after stream adds, continues stirring 4-5 hours；Filtering, washs filter cake with 50-60% ethanol water, dries.The present invention provides a kind of preparation methods of small grain size ambrisentan, provide the bulk pharmaceutical chemicals that can directly use for ambrisentan preparation, reduce environmental pollution, provide good working environment for preparation worker.
Description
Technical field
The present invention relates to a kind of purification process of small grain size ambrisentan, belong to bulk pharmaceutical chemicals preparation technical field.
Background technique
Ambrisentan, chemical name 2- (4,6- dimethyl pyrimidine -2- base) oxygroup -3- methoxyl group -3,3- diphenyl-propionic acid, Pueraria lobota
The SmithKline Lan Su company develops, all Rakes of trade name (VOLIBRIS).
Ambrisentan piece is a kind of specific endothelin receptor A(ETA receptor) depressant, the specification of the medicine thin membrane coated tablet
For 5,10 mg/ pieces, in June, 2007 is ratified to list by FDA.The medicine can be by acting on patients with pulmonary hypertension in vivo functionality hair
The raw Endothelin and its receptor changed, anti-hemostatic tube excessive shrinkage, and then alleviate disease symptoms, PAH patients ' life quality is improved,
Improve survival state.Ambrisentan is not soluble in water, and Chinese patent 201410668103.5 is crushed using micromill process
It is 5-100 microns to partial size, to improve dissolution rate.But the process of bean vermicelli, first is that preparation process is extended, second is that during bean vermicelli
The particle of formation can be diffused into the air of surrounding, cause environmental pollution.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of purification process of small grain size ambrisentan, to adapt to difference
Particular/special requirement of the preparation process to bulk pharmaceutical chemicals.
The technical scheme is that a kind of purification process of small grain size ambrisentan, comprising the following steps:
Ambrisentan crude product is dissolved in ethyl acetate by the first step, filtering；Preparation concentration range is 0.14g/ml to 0.26g/
The ambrisentan solution of ml；
Filtrate obtained by the second step first step is cooled to -5 to 5 DEG C, and maintains, and stirring flows down plus 1.5-3 times of first step solvent volume
50-60% ethanol water；Mixing speed is 230-270 revs/min, and the speed of stream plus ethanol water is 8-15ml/ points, stream
After adding, continue stirring 4-5 hours；
Third step filtering, washs filter cake with 50-60% ethanol water, dries.
Preferably, first step acquired solution concentration is 0.15-0.18 g/ml solution.
Preferably, second step crystallization temperature is -2 DEG C to 2 DEG C；The concentration of stream plus ethanol water is 55%；Stream plus ethanol water
The speed of solution is 10-12ml/ points.
Preferably, if crude product appearance is bad, active carbon can be added into first step solution, stir, filtering.
The utility model has the advantages that being provided the present invention provides a kind of preparation method of small grain size ambrisentan for ambrisentan preparation
The bulk pharmaceutical chemicals that can directly use, eliminate micronization program, reduce environmental pollution, provide well for preparation worker
Working environment.
The embodiment embodiment of the present invention uses prior art preparation with ambrisentan crude product, and HPLC detection level is
95.64%。
Embodiment 1.
14g ambrisentan crude product is dissolved in 100ml ethyl acetate by the first step, filtering；Preparing concentration is that 0.14g/ml peace is vertical
Raw smooth solution；
1g active carbon is added into first step solution for second step, stirs 1.5 hours, filtering；
Filtrate obtained by third step second step is cooled to -5 DEG C, and maintains, and stirring flows down plus 60% ethanol water of 150ml；Stirring
Speed is 230 revs/min, and the speed of stream plus ethanol water is 8ml/ points, after stream adds, continues stirring 4 hours；
The filtering of 4th step is washed filter cake 3 times with 60% ethanol water, uses 8ml, 80 DEG C of drying every time.Obtain ambrisentan essence
Product, it is 99.56% that HPLC, which detects purity, yield 93.38%, and D90 is 40.61 microns.
Embodiment 2.
26g ambrisentan crude product is dissolved in 100ml ethyl acetate by the first step, filtering；Prepare the peace that concentration is 0.26g/ml
Li Shengtan solution；
Filtrate obtained by the second step first step is cooled to 5 DEG C, and maintains, and stirring flows down plus 50% ethanol water of 300ml；Stirring
Speed is 270 revs/min, and the speed of stream plus ethanol water is 15ml/ points, after stream adds, continues stirring 5 hours；
Third step filtering is washed filter cake 3 times with 50% ethanol water, uses 10ml, 80 DEG C of drying every time.Obtain ambrisentan essence
Product, it is 99.86% that HPLC, which detects purity, yield 92.43%, and D90 is 24.38 microns.
Embodiment 3
17g ambrisentan crude product is dissolved in 100ml ethyl acetate by the first step, filtering；Prepare the peace that concentration is 0.17g/ml
Li Shengtan solution；
Filtrate obtained by the second step first step is cooled to 0 DEG C, and maintains, and stirring flows down plus 55% ethanol water of 220ml；Stirring
Speed is 250 revs/min, and the speed of stream plus ethanol water is 11ml/ points, after stream adds, continues stirring 4.5 hours；
Third step filtering is washed filter cake 3 times with 55 ethanol waters, uses 9ml, 80 DEG C of drying every time.Obtain ambrisentan essence
Product, it is 99.76% that HPLC, which detects purity, yield 92.73%, and D90 is 27.41 microns.
Claims (5)
1. a kind of purification process of small grain size ambrisentan, which comprises the following steps:
Ambrisentan is dissolved in ethyl acetate by the first step, filtering；Preparing concentration range is 0.14g/ml to 0.26g/ml's
Ambrisentan solution；
Filtrate obtained by the second step first step is cooled to -5 to 5 DEG C, and maintains, and stirring flows down plus 1.5-3 times of first step solvent volume
50-60% ethanol water；Mixing speed is 230-270 revs/min, and the speed of stream plus ethanol water is 8-15ml/ points, stream
After adding, continue stirring 4-5 hours；
Third step filtering, washs filter cake with 50-60% ethanol water, dries.
2. the purification process of small grain size ambrisentan according to claim 1, which is characterized in that first step acquired solution concentration
For 0.15-0.18 g/ml solution.
3. the purification process of small grain size ambrisentan according to claim 1, which is characterized in that second step crystallization temperature is -2
DEG C to 2 DEG C.
4. the purification process of small grain size ambrisentan according to claim 1, which is characterized in that stream plus ethyl alcohol described in second step
The concentration of aqueous solution is 55%.
5. the purification process of small grain size ambrisentan according to claim 1, which is characterized in that stream plus ethyl alcohol described in second step
The speed of aqueous solution is 10-12ml/ points.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811164803.5A CN109320464A (en) | 2018-10-07 | 2018-10-07 | A kind of purification process of small grain size ambrisentan |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811164803.5A CN109320464A (en) | 2018-10-07 | 2018-10-07 | A kind of purification process of small grain size ambrisentan |
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| CN109320464A true CN109320464A (en) | 2019-02-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109320463A (en) * | 2018-10-07 | 2019-02-12 | 威海贯标信息科技有限公司 | A kind of purification process of small grain size ambrisentan |
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| US20110189243A1 (en) * | 2008-08-11 | 2011-08-04 | Ratiopharm Gmbh | Pharmaceutical formulation for lowering pulmonary blood pressure |
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| CN102887861A (en) * | 2011-07-18 | 2013-01-23 | 天津市医药集团技术发展有限公司 | New crystal form of Ambrisentan and preparation method thereof |
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| CN103524424A (en) * | 2012-07-04 | 2014-01-22 | 天津药物研究院 | Crystal form VI of ambrisentan as well as preparation method and application thereof |
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| CN105581990A (en) * | 2014-08-27 | 2016-05-18 | 人福医药集团股份公司 | Ambrisentan tablet and preparation method thereof |
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| CN108586431A (en) * | 2018-07-09 | 2018-09-28 | 威海云睿信息科技有限公司 | A kind of purification process of small grain size nilotinib |
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2018
- 2018-10-07 CN CN201811164803.5A patent/CN109320464A/en not_active Withdrawn
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|---|---|---|---|---|
| US20110189243A1 (en) * | 2008-08-11 | 2011-08-04 | Ratiopharm Gmbh | Pharmaceutical formulation for lowering pulmonary blood pressure |
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| CN102887861A (en) * | 2011-07-18 | 2013-01-23 | 天津市医药集团技术发展有限公司 | New crystal form of Ambrisentan and preparation method thereof |
| CN103524424A (en) * | 2012-07-04 | 2014-01-22 | 天津药物研究院 | Crystal form VI of ambrisentan as well as preparation method and application thereof |
| CN103860525A (en) * | 2012-12-11 | 2014-06-18 | 天津药物研究院 | Capsule-type powder inhalation containing effective component ambrisentan and preparation technology thereof |
| CN103396370A (en) * | 2013-07-26 | 2013-11-20 | 浙江华海药业股份有限公司 | Method for purifying ambrisentan |
| CN105581990A (en) * | 2014-08-27 | 2016-05-18 | 人福医药集团股份公司 | Ambrisentan tablet and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109320463A (en) * | 2018-10-07 | 2019-02-12 | 威海贯标信息科技有限公司 | A kind of purification process of small grain size ambrisentan |
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