CN109312338B - 治疗单纯疱疹病毒的crispr/cas相关方法及组合物 - Google Patents

治疗单纯疱疹病毒的crispr/cas相关方法及组合物 Download PDF

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CN109312338B
CN109312338B CN201680074667.3A CN201680074667A CN109312338B CN 109312338 B CN109312338 B CN 109312338B CN 201680074667 A CN201680074667 A CN 201680074667A CN 109312338 B CN109312338 B CN 109312338B
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gene
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CN109312338A (zh
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A·E·弗里德兰
P·奥唐纳尔
D·A·邦姆克罗特
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Editas Medicine Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
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    • A61P31/12—Antivirals
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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CN201680074667.3A 2015-10-30 2016-10-28 治疗单纯疱疹病毒的crispr/cas相关方法及组合物 Active CN109312338B (zh)

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US201562249159P 2015-10-30 2015-10-30
US201562249071P 2015-10-30 2015-10-30
US62/249,071 2015-10-30
US62/249,159 2015-10-30
PCT/US2016/059502 WO2017075475A1 (en) 2015-10-30 2016-10-28 Crispr/cas-related methods and compositions for treating herpes simplex virus

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WO2017075475A1 (en) 2017-05-04
JP2024055867A (ja) 2024-04-18
US11001844B2 (en) 2021-05-11
AU2016343991B2 (en) 2022-12-01
JP2022068156A (ja) 2022-05-09
CN115491373A (zh) 2022-12-20
CA3001711A1 (en) 2017-05-04
US11834649B2 (en) 2023-12-05
EP3368670A1 (en) 2018-09-05
JP2018533375A (ja) 2018-11-15
JP7408284B2 (ja) 2024-01-05
CN109312338A (zh) 2019-02-05
AU2022271376B2 (en) 2025-08-28
AU2016343991A1 (en) 2018-04-12
US20220010313A1 (en) 2022-01-13
AU2022271376B9 (en) 2025-09-11
AU2022271376A1 (en) 2023-03-02
US20180251770A1 (en) 2018-09-06

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