CN109303569A - A method of brain dynamic hemotoncus is increased using dual intensity spectrum CT imaging and is imaged - Google Patents
A method of brain dynamic hemotoncus is increased using dual intensity spectrum CT imaging and is imaged Download PDFInfo
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- 230000001965 increasing effect Effects 0.000 title claims abstract description 10
- 238000013170 computed tomography imaging Methods 0.000 title claims abstract description 4
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 8
- 229910052740 iodine Inorganic materials 0.000 claims description 8
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- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 238000007689 inspection Methods 0.000 abstract description 3
- 238000002955 isolation Methods 0.000 abstract description 3
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- 239000000193 iodinated contrast media Substances 0.000 description 9
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 8
- 230000001154 acute effect Effects 0.000 description 7
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- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 206010053942 Cerebral haematoma Diseases 0.000 description 1
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- 238000000338 in vitro Methods 0.000 description 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a kind of methods for increasing imaging to brain dynamic hemotoncus using dual intensity spectrum CT imaging, choose the region that brain needs to scan, brain detection zone applies nonionic point contrast medium, and CTA inspection unenhanced to region progress CT determines that brain target detects object area.Using GSI scan pattern, the mixed tensor image data of above-mentioned zone height energy is obtained, mixed tensor image data is changed into the monoergic image data of substratess confrontation；Above-mentioned monoergic image data is reconstructed using substratess matter decomposition model；Image data is analyzed using base species analysis software, is shown, the information such as position, size, form, the density of brain target detectable substance are obtained.The present invention uses the substratess matter isolation technics of power spectrum CT, realize transformation of the mixed tensor to monoergic, influence of the hemotoncus density to CTA original image " point is levied " observation can be effectively removed, it is excessively high to solve the problems, such as that CTA mixed tensor figure prediction hemotoncus increases false negative rate.
Description
Technical field
The present invention relates to a kind of methods for increasing imaging to brain dynamic hemotoncus using dual intensity spectrum CT.
Background technique
Cerebral hemorrhage accounts for about the 10%-30% of cerebral apoplexy case, and lethality and disability rate are high.Prognosis of Acute Intracerebral Hemorrhage forms hemotoncus
At the beginning of morbidity be it is unstable, before sludged blood does not block bleeding part, hemotoncus can constantly increase.Theoretically, only
To there are the patients with cerebral hemorrhage of active hemorrhage need to just carry out hemostatic treatment, but due to the limitation of current Examined effect, Wu Fazao
Phase filters out the patient of active hemorrhage, thus cannot provide foundation for clinical selectivity hemostatic treatment.
The imageological examination that prediction acute cerebral hemorrhage hemotoncus increases mainly have at present CT unenhanced, single phase phase CTA, Dynamic CT A,
The method of CTP.The unenhanced diagnosis and screening for patients with cerebral hemorrhage of CT.The study found that Density inhomogeneity, form are irregular and go out
The hemotoncus of existing liquid horizontal line can tentative prediction hemotoncus increase, " black hole sign " proposed in recent years and " mixing sign " improve the spy of diagnosis
The opposite sex, but it can only provide the tendency of hematoma Enlargement in Spontaneous, lack reliability in clinical application.It is non-in hemotoncus in CTA original image
The dotted reinforcing stove in blood vessel traveling area is defined as " point sign is positive ", and pathologic basis is that iodine caused by the bleeding of blood vessel partial fracture compares
Agent is exosmosed, and " point sign " positive is the important iconography mark predicting acute cerebral hemorrhage (within 6 hours of onset) hemotoncus and increasing in hemotoncus
Will.The original image of single phase phase CTA is the method for " point sign " in earliest observation hemotoncus, it has already been proven that CTA " point sign " and intracerebral blood
The swollen progress that increases has correlation, has patient's mostly clinical prognosis of " point sign " poor.But since its image is mixed tensor
Figure, observer strengthen stove and are difficult to judge whether it has iodine contrast medium leakage, make in the hemotoncus for being equal to or less than hemotoncus density
It is excessively high at false negative rate.In order to observe the dynamic changes of " point sign ", in recent years, Dynamic CT A and CTP are used for acute brain in succession
The research of " point sign " in bleeding hemotoncus.Its advantage is the strengthening process of dynamic observation " point sign ", and predictive ability is higher than single phase phase
CTA.But Dynamic CT A and CTP are checked and are increased patient's x-ray radiation dosage, and there are still for being equal to or less than hemotoncus density
Hemotoncus in strengthen the problem of stove is difficult to judge whether there is iodine contrast medium leakage.Simultaneously as CTP scans with a thickness of 5-12mm,
Small reinforcing stove is still identified unclear.Therefore, the standard increased at present there is an urgent need to improve prediction Prognosis of Acute Intracerebral Hemorrhage hemotoncus
True property.
Dual intensity spectrum CT is suggested in nineteen seventies.With the development of X-ray detector and imaging system, dual intensity
CT is widely used.In recent years, with the further demand that the development of the relevant technologies such as detector and CT are imaged, make
With dual intensity or multipotency (be imaged that is, passing through the signal that object is formed using the X-ray of >=2 power spectrums, it is commonly referred to as multiple
Can window or energy channel X-ray) power spectrum CT receive extensive attention, and it is flourishing in practical applications.Compared to traditional
It is single can CT, power spectrum CT not only without spectral hardening and insufficient contrast the disadvantages of, but also material can be distinguished, especially in certain energy
The lower material with same absorbent coefficient of amount.These advantages make power spectrum CT, and there are many clinical application such as abdomen imagings and lung disease inspection
Survey etc..Power spectrum CT can be effectively reduced metal artifacts relative to traditional CT, improve the contrast of image, and be capable of providing object
Composition information.To, power spectrum CT is of great significance in fields such as clinical medicine diagnosis, non-destructive testing and safety inspections, and
It is more and more widely used.
Summary of the invention
To solve drawbacks described above existing in the prior art, CT pairs is composed using dual intensity the purpose of the present invention is to provide a kind of
The method that brain dynamic hemotoncus increases imaging.In this method, spectral imaging realizes transformation of the mixed tensor to monoergic, passes through
GSI(gemstone spectral image) scanning, conventional mixed tensor figure, iodo figure and water base figure can be provided.In iodo
In figure, iodine contrast medium shows as high density, and hemotoncus and water show as low-density, can effectively remove hemotoncus density to strong in hemotoncus
The cover and interference for changing stove reach the technical effect of early detection contrast medium leakage, and it is accurate that raising hemotoncus region growing for image is shown
Property.
The present invention is realized by following technical proposals.
A method of brain dynamic hemotoncus is increased using dual intensity spectrum CT and is imaged, comprising the following steps:
Step 1, the region that measured object (brain) needs to scan is chosen, nonionic point contrast medium is applied to the region, it is flat to carry out CT
It sweeps and is checked with CTA, determine target detection object area；Wherein, the unenhanced parameter of CT is thickness 9mm on curtain, 4.5mm, 120kv under curtain,
310mA, FOV 24cm, power spectrum CT are that 140KVp and 80KVp switches in 0.5ms, tube current 600mA, revolving speed 0.6s/rot；
Step 2, using GSI scan pattern, the low energy CT for obtaining power spectrum CT image of the above-mentioned zone under low dosage ray is thrown
Shadow data and high-energy CT data for projection form mixed tensor image data and store；
Step 3, Data correction, denoising are carried out to above-mentioned data, according to the normalized response of energy spectrum characteristics curve and spectrum, carried out
Projector space decomposes, for generating selective substratess matter image or selection energy diagram picture, according to the material density of substratess matter, line
Property attenuation coefficient, by mixed tensor image data be changed into substratess confrontation monoergic image data；Wherein, verify can be with for substratess
It is that the substratess such as water-iodine, water-aluminium are verified；
Step 4, the separation of dual intensity quantity of material is carried out based on substance attenuation coefficient, using substratess matter decomposition model to above-mentioned monoergic figure
As data are reconstructed；Wherein, image is reconstructed can be using reconstructing methods such as FBP, BFP
Step 5, the image data that step 4 obtains analyzed using base species analysis software, shown, contrast medium shows as height
Density, target detection thing show as low-density, have contrast medium exudation in substratess matter figure, all shown as highly dense in substratess matter figure
Degree, to obtain having to have no contrast the information such as agent exudation and its position, size, form, density, content of iodine in target detection thing.
The present invention realizes transformation of the mixed tensor to monoergic by using the substratess matter isolation technics of power spectrum CT, mixes
The picture quality of energy is closed better than the picture quality that monoergic data under the conditions of same dose generate, and scanning dose is only single energy
The half of amount.Low energy can highlight the reinforcing effect of iodine, but will increase picture noise, and high-energy can lower the enhancing effect of iodine
Fruit, but picture noise can be lowered.By the mixed image of height energy, the image matter due to simple high or low energy can be generated
Amount.
The present invention passes through GSI(gemstone spectral image) scanning, in the detection of in vitro tissue hemotoncus,
Iodine contrast medium shows as high density in iodo figure, and hemotoncus shows as low-density, can effectively remove hemotoncus density to CTA original graph
The influence of picture " point sign " observation solves the problems, such as that CTA mixed tensor figure prediction hemotoncus growth false negative rate is excessively high, can send out in early days
Existing iodine contrast medium leakage, i.e. " iodine sign " improve the accuracy that prediction Prognosis of Acute Intracerebral Hemorrhage hemotoncus increases.
Detailed description of the invention
Fig. 1 is the frame diagram for increasing the method for imaging to brain dynamic hemotoncus using dual intensity spectrum CT.
Specific embodiment
Test object is the hemotoncus in brain tissue.
The following steps are included:
Step 1, the region that measured object needs to scan is chosen, the nonionic point contrast medium containing iodine, such as Iohexol are applied to the region
(300mgI/ml) etc.；Using 750 jewel power spectrum CT examination machine of GE company of U.S. Discovery, it is unenhanced that CT is carried out to the region
It is checked with CTA, determines target detection object area；The unenhanced parameter of CT is thickness 9mm on curtain, 4.5mm, 120kv, 310mA under curtain,
FOV (field of view) 24cm, power spectrum CT are that 140KVp and 80KVp switches in 0.5ms, tube current 600mA, revolving speed
0.6s/rot。
Step 2, using GSI scan pattern, the low energy of power spectrum CT image of the above-mentioned zone under low dosage ray is obtained
CT data for projection and high-energy CT data for projection form mixed tensor image data, and store；The unenhanced parameter of CT is on tentorium cerebelli
Thickness 9mm, 4.5mm, 120kv, 310mA under curtain, FOV (field of view) 24cm.
Step 4, Data correction, denoising are carried out to above-mentioned dual intensity data, according to the standardization of energy spectrum characteristics curve and spectrum
Response carries out projector space decomposition, for generating selective substratess matter image or selection energy diagram picture, according to the object of substratess matter
Mixed tensor image data is changed into the monoergic image data of substratess confrontation (water and iodine) by matter density, linear attenuation coefficient；
Step 5, the separation of dual intensity quantity of material is carried out based on substance attenuation coefficient, using substratess matter decomposition model to above-mentioned monoergic figure
As data are reconstructed using FBP method；
Step 6, the image data that step 5 obtains analyzed using base species analysis software, shown, conventional CT enhancing scanning
The image seen is mixed tensor image, therefore when the density for strengthening stove in hemotoncus is equal to or less than the CT value of hemotoncus, is observed
Person is difficult to judge whether there is iodine contrast medium through in damaged vascular leakage to hemotoncus；Using the base species analysis in power spectrum CT, by
It is shown as low-density in substance separate picture in hemotoncus itself, as long as having the exudation of iodine contrast medium, nothing in hemotoncus in iodo figure
Be above by its density, be equal to or lower than hemotoncus density, high density can be shown as on iodo figure, obtain hemotoncus and exist
Whether whether uniformly, around whether regular, density have the information such as oedema for position, size of hematoma, form in brain tissue, makes to see
Examine the hemotoncus situation that sign is simple and clear, is easy in accurately discovery brain tissue.
Since the substratess matter isolation technics of jewel dual intensity spectrum CT can separate hemotoncus and iodine contrast medium, hemotoncus pair is excluded
The influence of " point sign ", while can be in hemotoncus and the leakage of " point is levied " interior iodine contrast medium quantitative determines, to infer urgency
Property Acute Hypertensive Intracerebral Hematoma in whether there is or not further active hemorrhage, predict that whether there is or not the growths of significant hemotoncus for hemotoncus, therefore, the present invention is fixed
Property the unenhanced hemotoncus of analysis CT, form whether rule, density whether uniformly, (" black hole sign " " mixes the special image sign of CT
Sign " etc.), tentatively judge the tendency of hematoma Enlargement in Spontaneous." point sign " positive patient, its point sign of qualitative analysis are checked in hemotoncus to CTA
Position, quantity and strengthen form, that evaluates that it increases with hemotoncus is associated with.After observing enhancing scanning using power spectrum CT iodo figure
Agent extravasation is had to have no contrast in CTA original image, quantitative determines in hemotoncus content of iodine in the content of iodine and hemotoncus of " point sign ".
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (1)
1. a kind of method for increasing imaging to brain dynamic hemotoncus using dual intensity spectrum CT imaging, which is characterized in that this method includes
Following steps:
Step 1, the region that selection brain needs to scan applies nonionic point contrast medium to the region, and progress CT is unenhanced and CTA is examined
It looks into, determines target detection object area；Wherein, the unenhanced parameter of CT is thickness 9mm on curtain, 4.5mm, 120kv, 310mA, FOV under curtain
24cm, power spectrum CT are that 140KVp and 80KVp switches in 0.5ms, tube current 600mA, revolving speed 0.6s/rot；
Step 2, using GSI scan pattern, the low energy CT for obtaining power spectrum CT image of the above-mentioned zone under low dosage ray is thrown
Shadow data and high-energy CT data for projection form mixed tensor image data and store；
Step 3, Data correction, denoising are carried out to above-mentioned data, according to the normalized response of energy spectrum characteristics curve and spectrum, carried out
Projector space decomposes, for generating selective substratess matter image or selection energy diagram picture, according to the material density of substratess matter, line
Property attenuation coefficient, by mixed tensor image data be changed into substratess confrontation monoergic image data；Wherein, verify can be with for substratess
It is that the substratess such as water-iodine, water-aluminium are verified；
Step 4, the separation of dual intensity quantity of material is carried out based on substance attenuation coefficient, using substratess matter decomposition model to above-mentioned monoergic figure
As data are reconstructed；Wherein, image is reconstructed can be using reconstructing methods such as FBP, BFP
Step 5, the image data that step 4 obtains analyzed using base species analysis software, shown, contrast medium shows as height
Density, target detection thing show as low-density, have contrast medium exudation in substratess matter figure, all shown as highly dense in substratess matter figure
Degree, to obtain having to have no contrast the information such as agent exudation and its position, size, form, density, content of iodine in target detection thing.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113100803A (en) * | 2021-04-20 | 2021-07-13 | 西门子数字医疗科技(上海)有限公司 | Method, apparatus, computer device and medium for displaying venous thrombosis |
| CN113796878A (en) * | 2021-09-10 | 2021-12-17 | 高阳 | Application of energy spectrum technology based on virtual anatomy in drowning case |
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2018
- 2018-09-21 CN CN201811110779.7A patent/CN109303569A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113100803A (en) * | 2021-04-20 | 2021-07-13 | 西门子数字医疗科技(上海)有限公司 | Method, apparatus, computer device and medium for displaying venous thrombosis |
| CN113796878A (en) * | 2021-09-10 | 2021-12-17 | 高阳 | Application of energy spectrum technology based on virtual anatomy in drowning case |
| CN113796878B (en) * | 2021-09-10 | 2024-04-19 | 高阳 | Application of energy spectrum technology based on virtual anatomy in drowning case |
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