CN109293773A - Target antibody, Chimeric antigen receptor and the drug of CD38 albumen - Google Patents
Target antibody, Chimeric antigen receptor and the drug of CD38 albumen Download PDFInfo
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- CN109293773A CN109293773A CN201811121365.4A CN201811121365A CN109293773A CN 109293773 A CN109293773 A CN 109293773A CN 201811121365 A CN201811121365 A CN 201811121365A CN 109293773 A CN109293773 A CN 109293773A
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- 210000000822 natural killer cell Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108010079317 prolyl-tyrosine Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
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- 235000020183 skimmed milk Nutrition 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201811121365.4A CN109293773B (en) | 2018-09-25 | 2018-09-25 | Antibodies, chimeric antigen receptors and drugs targeting CD38 protein |
Applications Claiming Priority (1)
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CN201811121365.4A CN109293773B (en) | 2018-09-25 | 2018-09-25 | Antibodies, chimeric antigen receptors and drugs targeting CD38 protein |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113811363A (en) * | 2019-03-29 | 2021-12-17 | 汉诺威医学院 | CAR FOR THE TREATMENT OF HvG DISEASE |
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CN1976950A (en) * | 2004-02-06 | 2007-06-06 | 莫佛塞斯公司 | Anti-CD38 human antibodies and uses therefor. |
CN101287764A (en) * | 2005-10-12 | 2008-10-15 | 莫佛塞斯公司 | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
CN101616933A (en) * | 2006-10-19 | 2009-12-30 | 赛诺菲-安万特 | The novel anti-cd 38 antibodies that is used for the treatment of cancer |
WO2016201394A1 (en) * | 2015-06-12 | 2016-12-15 | Miltenyi Biotec Technology, Inc. | Method to treat cancer with engineered t-cells |
CN107557388A (en) * | 2017-07-26 | 2018-01-09 | 生研医药科技(武汉)有限公司 | A kind of slow virus carrier prepared for CAR T and its construction method and application |
CN107683333A (en) * | 2015-03-11 | 2018-02-09 | 塞勒克提斯公司 | For being engineered allogeneic T cells to increase the method for its persistence and/or transplanting success in patients |
WO2018075794A1 (en) * | 2016-10-19 | 2018-04-26 | City Of Hope | Use of triplex cmv vaccine in car t cell therapy |
CN108276497A (en) * | 2018-01-26 | 2018-07-13 | 英普乐孚生物技术(上海)有限公司 | Target Chimeric antigen receptor T cell and its application of CD19 |
-
2018
- 2018-09-25 CN CN201811121365.4A patent/CN109293773B/en active Active
Patent Citations (8)
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CN1976950A (en) * | 2004-02-06 | 2007-06-06 | 莫佛塞斯公司 | Anti-CD38 human antibodies and uses therefor. |
CN101287764A (en) * | 2005-10-12 | 2008-10-15 | 莫佛塞斯公司 | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
CN101616933A (en) * | 2006-10-19 | 2009-12-30 | 赛诺菲-安万特 | The novel anti-cd 38 antibodies that is used for the treatment of cancer |
CN107683333A (en) * | 2015-03-11 | 2018-02-09 | 塞勒克提斯公司 | For being engineered allogeneic T cells to increase the method for its persistence and/or transplanting success in patients |
WO2016201394A1 (en) * | 2015-06-12 | 2016-12-15 | Miltenyi Biotec Technology, Inc. | Method to treat cancer with engineered t-cells |
WO2018075794A1 (en) * | 2016-10-19 | 2018-04-26 | City Of Hope | Use of triplex cmv vaccine in car t cell therapy |
CN107557388A (en) * | 2017-07-26 | 2018-01-09 | 生研医药科技(武汉)有限公司 | A kind of slow virus carrier prepared for CAR T and its construction method and application |
CN108276497A (en) * | 2018-01-26 | 2018-07-13 | 英普乐孚生物技术(上海)有限公司 | Target Chimeric antigen receptor T cell and its application of CD19 |
Non-Patent Citations (4)
Title |
---|
ESTHER DRENT ET AL: "Preclinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma", 《JOURNAL FOR IMMUNOTHERAPY OF CANCER》 * |
刘雪莹: "CAR-T细胞增强抗多发性骨髓瘤的实验研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
周远清: "人源化抗CD38抗体制备及生物学功能研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
温新宇: "人CD38分子的克隆表达、单克隆抗体的制备及其功能的初步研究", 《中国优秀博硕士学位论文全文数据库 (博士) 医药卫生科技辑》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113811363A (en) * | 2019-03-29 | 2021-12-17 | 汉诺威医学院 | CAR FOR THE TREATMENT OF HvG DISEASE |
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