CN109293505A - The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate - Google Patents
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate Download PDFInfo
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- CN109293505A CN109293505A CN201811373365.3A CN201811373365A CN109293505A CN 109293505 A CN109293505 A CN 109293505A CN 201811373365 A CN201811373365 A CN 201811373365A CN 109293505 A CN109293505 A CN 109293505A
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- Prior art keywords
- ethylene glycol
- citrate
- microwave heating
- container
- functional
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
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- Birds (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses the techniques for utilizing microwave heating technique production ethylene glycol citrate to be used for cosmetics, comprising the following steps: S1: fresh lemon is taken then to utilize squeezer that lemon is squeezed juice；S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；S3: container is placed in progress microwave heating polyester in microwave reactor；S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains the multi-functional citrate of ethylene glycol after lye neutralisation treatment is then added.The volume production of the multi-functional citrate of ethylene glycol is able to achieve in the present invention using the method for the microwave heating technique production multi-functional citrate of ethylene glycol, and the time for generating the multi-functional citrate of ethylene glycol is shorter, compared to the production method of the multi-functional citrate of existing ethylene glycol, its production time can shorten at least one times, production cost is saved, and the multi-functional citrate stability of ethylene glycol produced is high.
Description
Technical field
The present invention relates to a kind of techniques for producing multi-functional citrate, specifically produce second two using microwave heating technique
The technique that alcohol citrate is used for cosmetics.
Background technique
For ethylene glycol since molecular weight is low, property is active, can play the reaction such as esterification, etherificate, alcoholization, oxidation, acetal, dehydration,
It is similar to ethyl alcohol, ester can be mainly generated with inorganic or organic acid reaction, general first only one hydroxyl reacts, through increasing temperature
Degree, the sour dosage of increase etc., can make two hydroxyls all form ester.
At room temperature, citric acid is semi-transparent clear crystal or white particle or white crystalline powder to citric acid, odorless,
Taste is extremely sour, micro- in wet air to have hygroscopy.It can exist in the form of no hydrate or monohydrate: citric acid
When being crystallized from hot water, generate without hydrate；It is crystallized in cold water, generates monohydrate.It is heated to monohydrate at 78 DEG C
It can decompose to obtain no hydrate.At 15 degrees Celsius, citric acid can also dissolve in dehydrated alcohol.
Ethylene glycol can also form ethylene glycol citrate in conjunction with citric acid, but be obtained according to research, existing production second
The method of glycol citrate is unable to get stable ethylene glycol citrate and the time cycle is longer, generally requires 4-5h, nothing
Method meets batch requirements.
Summary of the invention
The purpose of the present invention is to provide the works for utilizing microwave heating technique production ethylene glycol citrate to be used for cosmetics
Skill, to solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme:
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: fresh lemon is taken then to utilize squeezer that lemon is squeezed juice；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container is placed in progress microwave heating polyester in microwave reactor；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol.
As a further solution of the present invention: in step sl, the lemon squeezing time is 2-2.5min.
As further scheme of the invention: in step s3, the microwave heating time is 1-2h.
As further scheme of the invention: in step s3, the microwave frequency is 2400-2500MHZ.
As further scheme of the invention: subtracting in the process of the vacuum distillation purification containing distilling apparatus, pumping
Pressure device and pressure measuring unit.
As further scheme of the invention: the distilling apparatus includes cucurbit, kirschner still head, straight condensation
Pipe, vacuum connect skirt and receiving flask.
Compared with prior art, the beneficial effects of the present invention are: producing ethylene glycol using microwave heating technique in the present invention
The method of multi-functional citrate is able to achieve the volume production of the multi-functional citrate of ethylene glycol, and generates the multi-functional citric acid of ethylene glycol
The time of ester is shorter, and compared to the production method of the multi-functional citrate of existing ethylene glycol, the production time can shorten at least one
Times, production cost is saved, and the multi-functional citrate stability of ethylene glycol produced is high.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 1h, microwave frequency in microwave reactor, is
2500MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Embodiment 2
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 1.2h, microwave frequency in microwave reactor, is
2480MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Embodiment 3
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 1.4h, microwave frequency in microwave reactor, is
2460MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Embodiment 4
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 1.6h, microwave frequency in microwave reactor, is
2440MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Embodiment 5
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 1.8h, microwave frequency in microwave reactor, is
2420MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Embodiment 6
The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate, comprising the following steps:
S1: taking fresh lemon then to utilize squeezer that lemon is squeezed juice, and lemon squeezes the time as 2-2.5min；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container, which is placed in progress microwave heating polyester, microwave heating time 2h, microwave frequency in microwave reactor, is
2400MHZ；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol is evaporated under reduced pressure in purification process containing distilling apparatus, pumping decompressor and pressure measuring unit, distillation
Device includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Conclusion: second two is able to achieve using the method for the microwave heating technique production multi-functional citrate of ethylene glycol in the present invention
The volume production of the multi-functional citrate of alcohol, and the time for generating the multi-functional citrate of ethylene glycol is shorter, only needs 1-2h, compared to existing
The multi-functional citrate of ethylene glycol production method, the production time can shorten at least one times, save production cost, Er Qiesheng
The multi-functional citrate stability of the ethylene glycol of production is high.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (6)
1. the technique for utilizing microwave heating technique production ethylene glycol citrate to be used for cosmetics, which is characterized in that including following
Step:
S1: fresh lemon is taken then to utilize squeezer that lemon is squeezed juice；
S2: taking-up lemon juice is fitted into container and then dilute hydrochloric acid is added into container and is adjusted pH value to 6-6.5；
S3: container is placed in progress microwave heating polyester in microwave reactor；
S4: container is taken out from microwave reactor, and vacuum distillation purification process obtains second after lye neutralisation treatment is then added
The multi-functional citrate of glycol.
2. the method according to claim 1 using the microwave heating technique production multi-functional citrate of ethylene glycol, special
Sign is that in step sl, the lemon squeezing time is 2-2.5min.
3. the method according to claim 1 using the microwave heating technique production multi-functional citrate of ethylene glycol, special
Sign is that in step s3, the microwave heating time is 1-2h.
4. the method according to claim 1 using the microwave heating technique production multi-functional citrate of ethylene glycol, special
Sign is that in step s3, the microwave frequency is 2400-2500MHZ.
5. the method according to claim 1 using the microwave heating technique production multi-functional citrate of ethylene glycol, special
Sign is, in step s 4, distilling apparatus, pumping decompressor and survey press fitting is contained in the process of the vacuum distillation purification
It sets.
6. the method according to claim 5 using the microwave heating technique production multi-functional citrate of ethylene glycol, special
Sign is, the distilling apparatus includes that cucurbit, kirschner still head, straight cold finger, vacuum connect skirt and receiving flask.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811373365.3A CN109293505A (en) | 2018-11-19 | 2018-11-19 | The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811373365.3A CN109293505A (en) | 2018-11-19 | 2018-11-19 | The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate |
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| Publication Number | Publication Date |
|---|---|
| CN109293505A true CN109293505A (en) | 2019-02-01 |
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ID=65144017
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811373365.3A Withdrawn CN109293505A (en) | 2018-11-19 | 2018-11-19 | The technique for being used for cosmetics using microwave heating technique production ethylene glycol citrate |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112430186A (en) * | 2019-08-24 | 2021-03-02 | 韦尔化学性能产品有限公司 | Hydroxycarboxylic acid esters, process for their preparation and their use |
-
2018
- 2018-11-19 CN CN201811373365.3A patent/CN109293505A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112430186A (en) * | 2019-08-24 | 2021-03-02 | 韦尔化学性能产品有限公司 | Hydroxycarboxylic acid esters, process for their preparation and their use |
| EP3786150A1 (en) | 2019-08-24 | 2021-03-03 | WeylChem Performance Products GmbH | Hydroxycarboxylic acid esters, method for their preparation and their use |
| US11208372B2 (en) | 2019-08-24 | 2021-12-28 | Weylchem Performance Products, Gmbh | Hydroxy carboxylic acid esters, manufacturing process thereof and use thereof |
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Application publication date: 20190201 |
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