CN109289112B - Pipe with pH indicating function, preparation method thereof and catheter - Google Patents
Pipe with pH indicating function, preparation method thereof and catheter Download PDFInfo
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- CN109289112B CN109289112B CN201811425778.1A CN201811425778A CN109289112B CN 109289112 B CN109289112 B CN 109289112B CN 201811425778 A CN201811425778 A CN 201811425778A CN 109289112 B CN109289112 B CN 109289112B
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- catheter
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- transparent tube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0227—Materials having sensing or indicating function, e.g. indicating a pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
Abstract
The invention relates to the field of medical instruments, in particular to a pipe with a pH indicating function, a preparation method thereof and a catheter. The catheter body material provided by the invention is a self-developed pipe material, and the pipe material comprises a transparent pipe body and a pH indicator which is connected to the inner surface of the transparent pipe body through a chemical bond. According to the urine catheter provided by the invention, the pH indicator is arranged on the inner wall of the catheter body, the pH value of urine flowing through the urine catheter can be monitored in a color change mode, the real-time property of urine pH value detection is good, and the sensitivity is high; the transparent texture of the catheter is matched with the bending form of the catheter, so that the color information of the indicator is obtained, the indicating effect is amplified, and the observation is facilitated; simultaneously, because the pH indicator is fixed on the body inner wall of catheter through chemical bonding's mode, consequently have higher stability, do not take place the dissociation of pH indicator and drop at urine scouring class in-process, the cycle of warning cycle is long, and biological safety is high.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a pipe with a pH indicating function, a preparation method thereof and a catheter.
Background
Indwelling catheters are common technologies in clinical treatment and diagnosis, and play an irreplaceable role in solving abnormal urination and observing urine volume. However, urinary catheter-associated urinary tract infections are among the most common nosocomial infections in the clinic. Statistical data show that urinary tract infections account for around 40% of all hospital-acquired infections, with 80% of urinary tract infections caused by indwelling catheters.
The development of urinary tract infection related to the catheter is closely related to the crusting of the indwelling catheter for a long time. Catheter encrustation is mainly caused by urease-secreting bacteria (e.g., proteus mirabilis, proteus vulgaris, and providencia rettgeri). The urease secreted by the bacteria can specifically catalyze urea to decompose and generate ammonia, so that urine is changed from acidic to alkaline, and calcium and magnesium ions in the urine are precipitated to form crystals. These crystals accumulate in the bacterial biofilm, rendering the bacteria effective against attack by the host immune system and antibiotics, thereby severely reducing the effectiveness of later-stage antibacterial therapy. In addition, urinary tract bacteria form a crystalline biomembrane in the inner cavity of the catheter, block the pipeline and prevent urine from being discharged in time, which can cause pyelonephritis, septicemia or endotoxin shock of patients and even death.
Therefore, the pH value of urine flowing through the catheter is monitored in real time, the invasion condition of urease secreting bacteria to the urine is known, early warning is given to incrustation and blockage of the catheter, and the reference basis is provided for confirmation of the optimal time for treating urinary tract infection related to the catheter while the service cycle of the catheter is reasonably prolonged.
Disclosure of Invention
In view of the above, the invention aims to provide a tube with a pH indication function, a preparation method thereof and a catheter.
The invention provides a tube with a pH indicating function, which comprises a transparent tube body and a pH indicator connected to the inner surface of the transparent tube body through a chemical bond.
Preferably, the material of the transparent tube body comprises one or more of polyolefin, polyurethane, silicon rubber, latex and thermoplastic elastomer.
Preferably, the pH indicator comprises one or more of bromothymol blue, cresolphthalein, thymol blue, curcumin, neutral red and phenol red.
Preferably, the area of the region, connected with the pH indicator, on the inner surface of the transparent tube body accounts for 2-100% of the total area of the inner surface of the transparent tube body.
The invention provides a preparation method of the pipe in the technical scheme, which comprises the following steps:
a) carrying out plasma pretreatment on the inner surface of the transparent tube body to obtain a tube body with an activated inner surface;
b) adding the grafting liquid into the pipe body with the activated inner surface, and carrying out ultraviolet irradiation to obtain a pipe body with the graft modified inner surface;
c) and adding a pH indicator, a catalyst and a solvent into the pipe body with the inner surface subjected to grafting modification for reaction to obtain the pipe with the pH indicating function.
Preferably, in step b), the grafting solution contains a graft; the graft comprises one or more of hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, monopeglycol acrylate, monopeglycol methacrylate, 2-aminoethyl methacrylate and glycidyl methacrylate.
Preferably, in the step b), the wavelength of the ultraviolet radiation is 180-420 nm; the time of ultraviolet irradiation is 5-60 min.
Preferably, in step c), the catalyst is sulfuric acid, phosphoric acid, sulfonic acid, ferric trichloride or aluminum trichloride.
Preferably, in the step c), the reaction temperature is 20-120 ℃; the reaction time is 0.5-12 h.
The invention provides a catheter with a pH indicating function, wherein a catheter body of the catheter is made of a tube material according to the technical scheme.
Compared with the prior art, the invention provides a pipe with a pH indicating function, a preparation method thereof and a catheter. The catheter body material provided by the invention is a self-developed pipe material, and the pipe material comprises a transparent pipe body and a pH indicator which is connected to the inner surface of the transparent pipe body through a chemical bond. According to the urine catheter provided by the invention, the pH indicator is arranged on the inner wall of the catheter body, the pH value of urine flowing through the urine catheter can be monitored in a color change mode, the real-time property of urine pH value detection is good, and the sensitivity is high; the transparent texture of the catheter is matched with the bending form of the catheter, so that the color information of the indicator is obtained, the indicating effect is amplified, and the observation is facilitated; simultaneously, because the pH indicator is fixed on the body inner wall of catheter through chemical bonding's mode, consequently have higher stability, do not take place the dissociation of pH indicator and drop at urine scouring class in-process, the cycle of warning cycle is long, and biological safety is high. According to the invention, by monitoring the pH value of urine flowing through the catheter in real time, the invasion condition of urease secreting bacteria to the urine can be known, early warning is given to catheter incrustation and blockage, and a reference basis is provided for confirming the optimal time for treating urinary tract infection related to the catheter while the reasonable extension of the use period of the catheter is ensured.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a tube with a pH indicating function, which comprises a transparent tube body and a pH indicator connected to the inner surface of the transparent tube body through a chemical bond.
The invention provides a pipe which comprises a transparent pipe body and a pH indicator. The material of the transparent tube body is preferably a medical polymer material, including but not limited to one or more of polyolefin, polyurethane, silicone rubber, latex and thermoplastic elastomer; the polyolefins include, but are not limited to, polyvinyl chloride; the hardness of the transparent tube body is preferably 60-90A, and specifically can be 60A, 65A, 70A, 75A, 80A, 85A or 90A; the light transmittance of the transparent tube body is preferably 75-95%, and specifically can be 75%, 78%, 80%, 83%, 85%, 88%, 90%, 92% or 95%. The specific structure and size of the transparent tube body are not particularly limited in the invention, and those skilled in the art can design the structure of the transparent tube body and select the size of the catheter according to actual requirements.
In the present invention, the pH indicator is attached to the inner surface of the transparent tube body by a chemical bond, including but not limited to one or more of bromothymol blue, cresolphthalein, thymol blue, curcumin, neutral red, and phenol red. The source of the pH indicator is not particularly limited in the present invention, and any pH indicator of the above kind known to those skilled in the art, for example, commercially available ones, may be used.
In the present invention, the area of the region connecting the pH indicator to the inner surface of the transparent tube preferably occupies 2 to 100% of the total area of the inner surface of the transparent tube, and specifically may be 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 17%, 20%, 22%, 25%, 27%, 30%, 32%, 35%, 37%, 40%, 42%, 45%, 47%, 50%, 52%, 55%, 57%, 60%, 62%, 65%, 67%, 70%, 72%, 75%, 77%, 80%, 82%, 85%, 87%, 90%, 92%, 95%, 97%, or 100%.
The invention also provides a preparation method of the pipe material in the technical scheme, which comprises the following steps:
a) carrying out plasma pretreatment on the inner surface of the transparent tube body to obtain a tube body with an activated inner surface;
b) adding the grafting liquid into the pipe body with the activated inner surface, and carrying out ultraviolet irradiation to obtain a pipe body with the graft modified inner surface;
c) and adding a pH indicator, a catalyst and a solvent into the pipe body with the inner surface subjected to grafting modification for reaction to obtain the pipe with the pH indicating function.
In the method provided by the invention, the inner surface of the transparent tube body is firstly subjected to plasma pretreatment. The transparent tube is introduced above, and is not described herein again. In the plasma pretreatment process, the used gas is preferably one or more of air, oxygen, nitrogen, argon, hydrogen, ammonia and carbon dioxide; the flow rate of the gas is preferably 2 to 500cc/min, specifically 2cc/min, 5cc/min, 10cc/min, 20cc/min, 30cc/min, 40cc/min, 50cc/min, 100cc/min, 150cc/min, 200cc/min, 250cc/min, 300cc/min, 350cc/min, 400cc/min, 450cc/min or 500 cc/min; the power of the plasma pretreatment is preferably 20-800W, and specifically can be 20W, 30W, 40W, 50W, 60W, 70W, 80W, 90W, 100W, 120W, 150W, 170W, 200W, 220W, 250W, 270W, 300W, 320W, 350W, 370W, 400W, 420W, 450W, 470W, 500W, 520W, 550W, 570W, 600W, 620W, 650W, 670W, 700W, 720W, 750W, 770W or 800W; the pressure of the plasma pretreatment is preferably 5-100 Pa, and specifically can be 5Pa, 10Pa, 15Pa, 20Pa, 25Pa, 30Pa, 35Pa, 40Pa, 45Pa, 50Pa, 55Pa, 60Pa, 65Pa, 70Pa, 75Pa, 80Pa, 85Pa, 90Pa, 95Pa or 100 Pa; the time of the plasma pretreatment is preferably 1-30 min, and specifically can be 1min, 5min, 10min, 15min, 20min, 25min or 30 min. And after the plasma pretreatment is finished, obtaining a tube body with an activated inner surface.
And after obtaining the pipe body with the activated inner surface, adding the grafting liquid into the pipe body with the activated inner surface. Wherein the grafting solution contains a graft and a solvent; the graft includes, but is not limited to, one or more of hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, monopeglycol acrylate, monopeglycol methacrylate, 2-aminoethyl methacrylate, and glycidyl methacrylate; the solvent includes but is not limited to one or more of water, methanol, ethanol, isopropanol, diethyl ether, acetone, dimethylformamide, dimethylsulfoxide, trichloromethane and carbon tetrachloride; the content of the graft in the graft solution is preferably 0.01 to 0.5g/mL, and specifically may be 0.01g/mL, 0.03g/mL, 0.05g/mL, 0.08g/mL, 0.1g/mL, 0.13g/mL, 0.15g/mL, 0.18g/mL, 0.2g/mL, 0.23g/mL, 0.25g/mL, 0.28g/mL, 0.3g/mL, 0.33g/mL, 0.35g/mL, 0.38g/mL, 0.4g/mL, 0.43g/mL, 0.45g/mL, 0.48g/mL, or 0.5 g/mL. In the present invention, the amount of the graft solution used is preferably 2 to 100% of the internal volume of the tube, and specifically may be 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 17%, 20%, 22%, 25%, 27%, 30%, 32%, 35%, 37%, 40%, 42%, 45%, 47%, 50%, 52%, 55%, 57%, 60%, 62%, 65%, 67%, 70%, 72%, 75%, 77%, 80%, 82%, 85%, 87%, 90%, 92%, 95%, 97%, or 100%. And after the grafting solution is added, carrying out ultraviolet irradiation on the tube body. Wherein, the light source of the ultraviolet radiation is preferably one or more of a low-pressure mercury lamp, a medium-pressure mercury lamp, a high-pressure mercury lamp, a iodine-tungsten lamp and a light filter; the wavelength of the ultraviolet radiation is preferably 180-420 nm, and specifically can be 180nm, 200nm, 220nm, 240nm, 254nm, 260nm, 280nm, 300nm, 320nm, 340nm, 360nm, 365nm, 380nm, 400nm or 420 nm; the time of the ultraviolet irradiation is preferably 5-60 min, and specifically can be 5min, 10min, 15min, 20min, 25min, 30min, 35min, 40min, 45min, 50min, 55min or 60 min. And after the ultraviolet irradiation is finished, washing the irradiated tube body to obtain the tube body with the inner surface grafted and modified.
After obtaining the pipe body with the graft modified inner surface, adding a pH indicator, a catalyst and a solvent into the pipe body with the graft modified inner surface. Wherein, the pH indicator is already introduced in the above and is not described in detail herein; the catalyst includes, but is not limited to, sulfuric acid, phosphoric acid, sulfonic acid, ferric trichloride, or aluminum trichloride; the solvent includes but is not limited to one or more of water, methanol, ethanol, isopropanol, diethyl ether, acetone, dimethylformamide, dimethyl sulfoxide, trichloromethane and carbon tetrachloride; the ratio of the mass of the pH indicator to the total volume of the pH indicator, the catalyst and the solvent is preferably (0.01-20) g:100mL, specifically 0.01g:100mL, 0.1g:100mL, 0.5g:100mL, 1g:100mL, 3g:100mL, 5g:100mL, 8g:100mL, 10g:100mL, 12g:100mL, 15g:100mL, 18g:100mL or 20g:100 mL; the ratio of the mass of the catalyst to the total volume of the pH indicator, the catalyst and the solvent is preferably (0.01-5) g:100mL, specifically 0.01 g/100 mL, 0.1 g/100 mL, 0.3 g/100 mL, 0.5 g/100 mL, 0.8 g/100 mL, 1 g/100 mL, 1.5 g/100 mL, 2 g/100 mL, 2.5 g/100 mL, 3 g/100 mL, 3.5 g/100 mL, 4 g/100 mL, 4.5 g/100 mL, or 5 g/100 mL. And after the pH indicator, the catalyst and the solvent are added, carrying out reaction. Wherein the reaction temperature is preferably 20-120 deg.C, specifically 20 deg.C, 25 deg.C, 30 deg.C, 35 deg.C, 40 deg.C, 45 deg.C, 50 deg.C, 55 deg.C, 60 deg.C, 65 deg.C, 70 deg.C, 75 deg.C, 80 deg.C, 85 deg.C, 90 deg.C, 95 deg.C, 100 deg.C, 105 deg.C, 110 deg.C; the reaction time is preferably 0.5-12 h, and specifically can be 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 4.5h, 5h, 5.5h, 6h, 6.5h, 7h, 7.5h, 8h, 8.5h, 9h, 9.5h, 10h, 10.5h, 11h, 11.5h or 12 h. And after the reaction is finished, washing and drying the reacted pipe body to obtain the pipe with the pH indicating function.
The inner wall of the pipe provided by the invention is provided with the pH indicator, the pH value of liquid flowing through the pipe can be monitored in a color change mode, the real-time performance of liquid pH value detection is good, and the sensitivity is high; the transparent texture of the pipe is matched with the bending form of the conduit, so that the color information of the indicator is obtained, the indicating effect is amplified, and the observation is facilitated; simultaneously, because the pH indicator is fixed on the body inner wall of tubular product through chemical bonding's mode, consequently have higher stability, do not take place dissociation of pH indicator and drop at liquid scouring and so on in-process, the cycle of warning cycle is long, and biological safety is high.
The invention also provides a catheter with a pH indicating function, and the catheter body material of the catheter is the tube material in the technical scheme.
According to the urine catheter provided by the invention, the pH indicator is arranged on the inner wall of the catheter body, the pH value of urine flowing through the urine catheter can be monitored in a color change mode, the real-time property of urine pH value detection is good, and the sensitivity is high; the transparent texture of the catheter is matched with the bending form of the catheter, so that the color information of the indicator is obtained, the indicating effect is amplified, and the observation is facilitated; simultaneously, because the pH indicator is fixed on the body inner wall of catheter through chemical bonding's mode, consequently have higher stability, do not take place the dissociation of pH indicator and drop at urine scouring class in-process, the cycle of warning cycle is long, and biological safety is high. According to the invention, by monitoring the pH value of urine flowing through the catheter in real time, the invasion condition of urease secreting bacteria to the urine can be known, early warning is given to catheter incrustation and blockage, and a reference basis is provided for confirming the optimal time for treating urinary tract infection related to the catheter while the reasonable extension of the use period of the catheter is ensured.
For the sake of clarity, the following examples are given in detail.
Example 1
Preparation of urinary tract bacterial infection warning type catheter
A) The polyvinyl chloride catheter (with the hardness of 70A and the light transmittance of 92%) is pretreated by plasma, and the working parameters are as follows: the surface activated catheter is obtained by the power of 200W, the pressure of 15Pa, oxygen gas, the flow rate of 30cc/min and the time of 5 min.
B) Preparing an aqueous solution of 0.05g/mL hydroxyethyl methacrylate, and adding the aqueous solution into the inner cavity of the catheter with the surface activated, wherein the using amount of the solution is 100% of the volume of the inner cavity of the catheter; irradiating for 20min by using a high-pressure mercury lamp with the wavelength of 254nm and the power of 300W, and then ultrasonically oscillating and washing by using ethanol and deionized water to obtain the catheter with the surface grafted and modified;
C) adding a mixed solution of 0.05g/mL bromothymol blue and 0.01g/mL sulfuric acid in acetone into the inner cavity of the catheter with the surface graft modified until the solution is filled in the whole inner cavity; then, reacting for 4 hours at the temperature of 60 ℃ to ensure that the pH indicator is chemically bonded on the inner wall of the catheter; and ultrasonically oscillating and washing the sample by using ethanol and deionized water, and drying in vacuum to obtain the catheter with the pH indicating function.
Example 2
A) The polyurethane catheter (hardness 80A, light transmittance 88%) is pretreated by plasma, and the working parameters are as follows: the surface activated catheter is obtained by the power of 60W, the pressure of 15Pa, the air and the gas, the flow rate of 20cc/min and the time of 15 min.
B) Preparing an aqueous solution of 2-aminoethyl methacrylate with the concentration of 0.1g/mL, and adding the aqueous solution into the inner cavity of the catheter with the surface activated, wherein the using amount of the solution is 20 percent of the volume of the inner cavity of the catheter; irradiating for 10min by using a high-pressure mercury lamp with the wavelength of 365nm and the power of 300W, and then ultrasonically oscillating and washing by using ethanol and deionized water to obtain the catheter with the surface grafted and modified;
C) adding a mixed solution of 0.05g/mL of alpha-naphtholphthalein and 0.005g/mL of sulfuric acid in acetone into the inner cavity of the catheter with the surface modified by grafting until the solution is filled in the whole inner cavity; then, reacting for 12 hours at the temperature of 40 ℃ to ensure that the pH indicator is chemically bonded on the inner wall of the catheter; and ultrasonically oscillating and washing the sample by using ethanol and deionized water, and drying in vacuum to obtain the catheter with the pH indicating function.
Example 3
Preparation of urinary tract bacterial infection warning type catheter
A) The silicone rubber catheter (hardness 75A, light transmittance 80%) is pretreated by plasma, and the working parameters are as follows: the surface activated catheter is obtained by the power of 400W, the pressure of 40Pa, the oxygen gas, the flow rate of 40cc/min and the time of 30 min.
B) Preparing an aqueous solution of 0.05g/mL of methacrylic acid mono-polyethylene glycol, and adding the aqueous solution into the inner cavity of the catheter with the surface activated, wherein the using amount of the solution is 80% of the volume of the inner cavity of the catheter; irradiating for 10min by using a high-pressure mercury lamp with the wavelength of 365nm and the power of 300W, and then ultrasonically oscillating and washing by using ethanol and deionized water to obtain the catheter with the surface grafted and modified;
C) adding a mixed solution of 0.1g/mL bromothymol blue and 0.01g/mL sulfuric acid in acetone into the inner cavity of the catheter with the surface graft modified until the solution is filled in the whole inner cavity; then, reacting for 8 hours at the temperature of 70 ℃ to ensure that the pH indicator is chemically bonded on the inner wall of the catheter; and ultrasonically oscillating and washing the sample by using ethanol and deionized water, and drying in vacuum to obtain the catheter with the pH indicating function.
Example 4
Color Change Performance test
Introducing bacteria with a concentration of 10 into sterile artificial urine with pH of 6.110Mutant bacillus (cfu/ml) was cultured for 24 hours, and the obtained bacteria infected with artificial urine (pH 7.6). Sterile artificial urine and bacterial infection artificial urine were injected into the catheters prepared in examples 1 to 3, respectively, and the color change in the warning area in the catheters was recorded.
TABLE 1 color of urinary catheters under different circumstances
| Example 1 | Example 2 | Example 3 | |
| Color in air | Yellow colour | Light brown | Light orange color |
| Sterile artificial urine, pH6.1 | Yellow colour | Light brown | Orange color |
| Infected with artificial urine, pH7.6 | Deep blue color | Black color | Blue green color |
The obvious color difference of the urine catheter provided by the invention in different pH can be seen through the table 1, which shows that the urine catheter provided by the invention can effectively monitor the pH of urine flowing through the urine catheter, and the invasion condition of urease secreting bacteria to the urine can be known.
Example 5
Simulated infection testing of urinary catheters
The catheters prepared in examples 1 to 3 were connected to an infusion bag (simulated bladder) containing artificial urine, and fresh sterile artificial urine was pumped into the infusion bag at a flow rate of 0.75mL/min so that the urine in the infusion bag was kept in a dynamic equilibrium state between discharge and injection and the amount of urine was maintained at about 20mL (37 ℃). At the beginning of the experiment, 0.1mL of mutant bacillus (10) was injected into the infusion bag10cfu/ml). Respectively recording the time of warning and color change of the catheter and the time of pipeline blockage.
TABLE 2 time for warning, color change and pipeline blockage of catheter and early warning time of catheter
| Example 1 | Example 2 | Example 3 | Mean value of | |
| Warning color changing time/h | 24 | 22 | 26 | 24 |
| Pipeline plugging time/h | 54 | 48 | 66 | 56 |
| Early warning time/h | 30 | 26 | 40 | 32 |
It can be seen from table 2 that the catheter provided by the invention has early warning time of up to 40h for catheter incrustation and blockage in a simulated infection test. Because the simulation experiment adopts the bacteria concentration which is far higher than the actual infection event, the early warning time of the urinary tract bacterial infection warning type catheter in the actual use can be further prolonged, and enough time can be provided for the treatment of urinary tract infection related to the catheter.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A preparation method of a pipe with a pH indicating function comprises the following steps:
a) carrying out plasma pretreatment on the inner surface of the transparent tube body to obtain a tube body with an activated inner surface;
in the plasma pretreatment process, the used gas is one or more of air, oxygen, nitrogen, argon, hydrogen, ammonia and carbon dioxide, and the flow rate of the gas is 2-500 cc/min; the power of the plasma pretreatment is 20-800W, the pressure is 5-100 Pa, and the time is 1-30 min;
b) adding the grafting liquid into the pipe body with the activated inner surface, and carrying out ultraviolet irradiation to obtain a pipe body with the graft modified inner surface;
the grafting solution contains a graft; the graft comprises one or more of hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, monopeglycol acrylate, monopeglycol methacrylate, 2-aminoethyl methacrylate and glycidyl methacrylate;
c) adding a pH indicator, a catalyst and a solvent into the pipe body with the inner surface subjected to grafting modification, and reacting to obtain a pipe with a pH indicating function;
the tubing includes a transparent tube and a pH indicator chemically bonded to an inner surface of the transparent tube.
2. The method according to claim 1, wherein in step a), the material of the transparent tube body comprises one or more of polyolefin, polyurethane, silicone rubber, latex, and thermoplastic elastomer.
3. The method of claim 1, wherein in step c), the pH indicator comprises one or more of bromothymol blue, methynaphtholphthalein, thymol blue, curcumin, neutral red, and phenol red.
4. The preparation method according to claim 1, wherein in the step c), the area of the region of the inner surface of the transparent tube body connected with the pH indicator accounts for 2-100% of the total area of the inner surface of the transparent tube body.
5. The preparation method according to claim 1, wherein in step b), the wavelength of the ultraviolet radiation is 180-420 nm; the time of ultraviolet irradiation is 5-60 min.
6. The method according to claim 1, wherein in step c), the catalyst is sulfuric acid, phosphoric acid, sulfonic acid, ferric trichloride or aluminum trichloride.
7. The preparation method according to claim 1, wherein in the step c), the reaction temperature is 20-120 ℃; the reaction time is 0.5-12 h.
8. A catheter with a pH indicating function, wherein a catheter body material of the catheter is a pipe material prepared by the method of any one of claims 1-7.
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