CN109288603A - Improved orthodontia accelerator - Google Patents

Abstract

The present invention provides a kind of improved vibration orthodontia devices, and wherein motor speed is controlled by capacitance type sensor, and therefore without moving parts needed for encoder use.The improved device also uses tungsten to deviate weight, so that size be made to reduce 50% or more, but still generates required power.Therefore, described device is smaller, lighter and firmer.

Description

Improved orthodontia accelerator

Existing related application

This application claims the priority for the U.S. Provisional Application No. 60/906,807 that on March 14th, 2007 submits, and are The U.S. Application No. 11/773,849 (being published as US20080227046) (pending) submitted on July 5th, 2007 and U.S. Shen Please the parts of number 11/773,858 (being published as US20080227047) connect, the full content of each in the U. S. application It is incorporated herein by reference.This application is also the U.S. Application No. 12/615,049 submitted on November 9th, 2009 (US9028250), September in 2012 is submitted on the 11st U.S. Application No. 13/609,346 (pending), on November 22nd, 2012 submit U.S. Application No. 13/684,220 (US8500446) and August in 2013 submit within 22nd U.S. Application No. 13/973,865 (to Examine) part connect.The full content of each in these applications is incorporated herein by reference for all purposes.

Technical field

The present invention relates to the improved vibration devices for accelerating orthodontia to remold.

Background technique

Plate bite is the misalignment of tooth or the interdental incorrect relationship of two dental arch.The term is by Edward Angle, which is created in " father (father of modern orthodontics) of modern orthodontia " as what tooth closed, to spread out New word refers to the mode that opposed teeth meets.Angle establishes it in the opposite of maxillary first molar to the classification of plate bite On the basis of position.According to described in Angle, the nearly middle cheek point of maxillary first molar should be with the buccal groove pair of mandibular first molar It is quasi-.Tooth should be all fitted on line of occlusion, and the line of occlusion is one and passes through the central socket and cingulum of eyetooth, and wears Cross the cheek point of lower jaw and the smoothed curve of incisxal edge.Thus any variation can all lead to plate bite.

There is three classes plate bite: I class, II class and Group III.In addition, II class is subdivided into three kinds of hypotypes:

I class: neutral plate bite, the molar relation that tooth closes herein be it is normal or as it is described be the tooth of maxillary first molar It closes, but other teeth have the problem of such as spacing, crowded, eruption is excessive or eruption is insufficient etc.

II class: posterocclusion (retrognathia, covering) in this case, is above ground one's teeth in sleep and is not in mesiobuccal groove, but Its front.In general, cheek point is between the first lower molar and the second premolar teeth in close.There are two types of hypotypes:

II class 1 is classified: molar relation is that the relationship and labial teeth such as II class are prominent.

II class 2 is classified: molar relation is II class, but central incisor hypsokinesis, and visible lateral incisor is Chong Die with central incisor.

Group III: mesioversion malposition (prognathism covers repeatedly) in this case, is above ground one's teeth in sleep and is not in mesiobuccal groove, and It is in its rear.The nearly middle cheek point of maxillary first molar is located at behind the mesiobuccal groove of mandibular first molar.Instantly labial teeth ratio When Upper Anterior Teeth is more prominent, it is commonly seen this plate bite.In such cases, patient usually has big mandibular or short upper Jawbone.

Orthodontia (Orthodontics), be in the past orthodontia (from Greek, orthos refer to " it is straight or It is correctly or perfect "；And odous refers to " tooth "), be with the research of plate bite (inappropriate or abnormal be engaged) and Related profession is treated, this may be that tooth is irregular, caused by disproportionate facial skeleton relationship or both.Orthodontia is logical It crosses and is remolded via bone and plate bite is treated to carry out drifting tooth to the control and modification of facial growth.

Bone is remolded by the coaction of 3 kinds of cell types: osteoblast, osteocyte and osteoclast.Osteoblast It is the cell for generating osteocyte epimatrix and being responsible for its mineralising.Osteoblast also passes through the osteocalcin for adjusting fat and energetic supersession It secretes and there is Endocrine Activity.These cells also control the differentiation and activity of osteoclast.Osteocyte is to have been incorporated into bone base Osteoblast in matter, and be the cell with extensive dendron shape, cell by it is described it is tree-shaped it is prominent with other osteocytes and at Osteocyte connection.Mechanical load is transferred to participation control osteoblast and osteoclast function by dendron shape sensitization Biochemical reaction.Osteocyte participates in the fibroblast growth factor 23 of kidney phosphoric acid salt secretion by release, it may have interior point Secrete activity.The differentiation that osteoclast monocytic progenitors keep multinucleated osteoclast mature passes through macrophage colony-NF- κ B ligand Stimulating factor and receptor activator are adjusted, the stimulating factor and receptor activator by the stroma cell or bone in marrow at It osteocyte and is expressed by osteocyte.The synthesis endocrine of osteoblast, osteocyte and osteoclast and paracrine control for The remodeling and molding process (including during the tooth caused by orthodontia is mobile) for maintaining bone amount and controlling in bone are important.

Traditionally, the process of orthodontia bone remodeling causes bone remodeling by using static mechanical power, to make Obtaining tooth can move and realize.The method of this treatment plate bite accepted extensively averagely needs 24 months time It completes.In this approach, orthodontia support is made of arch wire, and the arch wire applies continuous static force and every with being affixed to The bracket of tooth interfaces with.For aesthetics and function/reasons in structure, support is ground one's teeth for treating many different classes of clinics Close, including anti-jaw, cover tooth close, anti-tooth close, open tooth close and irregular tooth.

Orthodontic treatment becomes complicated due to the fact that causing uncomfortable and/or pain to patient, and abnormal tooth Appliance be considered as it is inaesthetic, it is all these all generate use resistance.In addition, 24 months Mean treatment durations are very It is long, and usability and compliance are further decreased, it may include long-term undesirable oral hygiene.In fact, some estimations It provides, the less than half of patient that may benefit from this treatment selects to carry out orthodontia.

Kesling was proposed tooth positioner tool in 1945, completed as orthodontia after refinement debanding last The method of one step.Locator is to complete for base therapy but there is still a need for the manufactures of the patient refined on a small quantity to fill in ideal wax The single type flexible rubber utensil set.Kesling is also predicted, with the progress for the treatment of, certain main tooth movements can also To be completed with according to a series of locators of the mobile manufacture of orderly tooth on device.However, this idea was swept in 3D in 1997 Do not become practical before retouching the arrival with computer modeling.

Removable transparent utensil is had been incorporated into, such asSystem treats plate bite, and due to dress Setting is transparent and provides the aesthetics significantly improved.However, compliance can since these equipment can be removed It can be a problem, and slow down the wholistic therapy time.

As treatment mode, aligner is also restrained in the classification for the clinical plate bite that they are able to solve.In mistake It goes, aligner can not easily rotate or squeeze out tooth, because aligner can not fully directed force in all directions.Consciousness To these limitations, Align Technologies recently willTransparent aligner be attached to it is transparent on tooth Attachment is combined together, and can provide can surface in any desired orientation to its applied force.Using wherein with pit Proprietary modeling is used to place the 3D model of the patient teeth of power attachment to manufacture custom mold, the placement of power attachment and shape Software determines.It manufactures relevant power attachment and is assembled into mold, apply adhesive on attachment, and by mold It is applied on tooth.This allows accurately and quickly to place transparent attachment, then uses the affixed transparent attachment of photocuring.It is right Aesthetics has a certain impact, but since power attachment is also transparent, so they from seeing it is not apparent at a distance.

Other than static force, cyclic force can be used for orthodontia remodeling.When Kopher and Mao has evaluated rabbit 1Hz The cyclic force of 5N peak value, and Peptan and Mao have evaluated the cyclic force of 1N of the rabbit in 8Hz, and Vij and Mao have evaluated The cyclic force of rat 300mN in 4Hz.To sum up, this three research statistics indicate that, the circulation between 1Hz and 8Hz Power, the range of power are to increase bone remodeling from 0.3N to 5N.Rate depends on different methods, but vibration force increases by 2.5 times It is common.

The research of early stage Mao provides possible curative effect using vibration auxiliary orthodontia tooth movement for the mankind and may Safety basis.However, the earlier trials of Mao are to carry out on rabbit cranial bone suture closed model, and be constructed without Any device that can be used for human teeth.Therefore, although having hint property, need of work carries out weight on the tooth of people Again to prove its effect.But it is available without such device.

Inc. the first commercially successful tooth vibration device has been invented, such as Described in US20080027046, designed for applying cyclic force to denture to achieve the purpose that accelerate remodeling. It is described in US20080227046 in mouth and the outer embodiment of mouth, every kind of embodiment has and makes for capturing and transmitting patient With the processor of information.Biteplate is specially designed for the occlusal surface and tooth and/or facial surface of contact denture, and because This device in terms of vibration force is transmitted to tooth than any prior art is more effective.

In addition, described device is tested in human clinical trial, and shows to remold orthodontia and accelerate Up to 50%.Therefore, this is the really breakthrough (Kau 2010) to orthodontia technology.Finally, described device is slim, can exempt from Hand operation, the huge dental aligners without prior-art devices, and there is the optimization remolded for orthodontia Power and frequency.Therefore, it has been found that its comfort level and compliance are very high, and patient reports that they like described device, especially in horse Up to after being redesigned and be quieter and smoother, as described in US20100055634 etc..In fact, this device is several Country is by marketingAnd since being recently introduced, achieved significant business at Function.Represent by by Noninvasive and it is non-pharmacological in a manner of adjust bone biology and accelerate orthodontia tooth The successful clinical method of the first mobile.

However, above-mentioned apparatus further improvement it is always beneficial, and this application propose those improvement in it is some It improves.

Summary of the invention

In one aspect, orthodontic appliance includes Kou Nei denture circle of mouth outer vibration source and biteplate or flat form Face.Vibration source outside mouth is connected to attachment in mouth by device interface.

On the other hand, orthodontic appliance includes mouthful internal vibration source and the mouth internal gearing plate or platform that contact with denture.

In addition, biteplate can at any point or all point contact teeth.Biteplate can contact occlusal surface, and preferably Ground, biteplate contacts tongue or face (or two) surface of tooth, although specific panel can be designed for more complicated clinic It is abnormal.

Processor can control, sample and compensating port is outer or mouth internal vibration source.Processor runs software, the software capture Frequency of use and duration, and can be programmed to change power, frequency, waveform, amplitude, duration or any other operation Parameter.Frequency of use and duration can be passed to remotely by processor via any kind of wired or wireless communication method Computer.Processor can be on the internet via smart phone, or simply with other devices (for example, bluetooth, Wireless LAN Deng) communicated with remote computer.

Processor can be communicated initiatively to user to provide with device using related, especially and in biteplate or platform It is upper to be engaged really up to the mark or not hard enough relevant input.One kind can be provided based on humidity or temperature sensing or saliva mineral content sensing Or other similar mechanism measures proper use of mechanism, and can also provide feedback based on this control parameter.It will need to press Power detection technology accurately carries out this measurement, such as strain ga(u)ge, capacitor or piezoelectric element.

Preferably, customization or semi-custom specific integrated circuit (ASIC) are designed to drive described device, and for complete Full Oral appliances are particularly preferred.ASIC may include entire microprocessor；Including ROM, RAM, EEPROM, flash memory and other The memory block of large-scale structure block.Such ASIC is commonly known as SoC (system level chip).Hardware description language (HDL), it is all Such as Verilog or VHDL, it can be used for describing the function of ASIC.Field programmable gate array (FPGA) is for driving device Another kind selection.Programmable logic block and programmable interconnection piece allow for identical FPGA to be used for many different applications.For Lesser design and/or lower output, even if FPGA may also be more more cost effective than ASIC design in terms of production.

Another selection is using Structured ASIC design (also referred to as " platform ASIC design "), because with based on unit ASIC is compared, and is manufactured circulation time and design cycle time and is both reduced, because there are predefined metal layers (therefore to reduce Manufacturing time) and silicon on have the preparatory characterization (therefore reduce design cycle time) of what object.By creation customization metal layer come It realizes design difference and customization, customized connection can be created between predefined lower layer's logic element." structuring ASIC " technology is considered as having made the gap between field programmable gate array and " standard block " ASIC design up.Due to only A small amount of chip layer must be customized, so " ASIC of structuring " design and the " mark for requiring each design to produce full mask set Quasi- unit " or " full custom " chip are compared, and non-recurrent expenditure is much smaller.

For using compliance importantly, device is comfortable, and use will not be unpleasant.Early stage model tool There are different speed and power, when patient applies bigger power to biteplate, slow down, and this irregular vibration causes one It stimulates a bit and reduces compliance-this is the unpredictable problem of the vibration device of any prior art.Therefore, device is by again It designs to carry out the operation of smoother (and quieter).

Specifically, a kind of constant safely and effectively method for oscillating is developed, the method includes providing vibrating motor, institute Vibrating motor is stated with the encoder for being operably connected to the processor with software, the software is to the first encoder event Time between second encoder event is counted；The time is compared with target frequency；Via pulsewidth modulation To adjust motor speed to increase or decrease the motor speed optionally to maintain the target frequency；So that using the side The vibration orthodontia remodeling device including mouth internal gearing plate and the outer vibration source of mouth of method is engaged simultaneously in the biteplate by patient And described device is when being activated, changed between 20-40Hz for≤2Hz's (for example, frequency only adds and subtracts 2Hz from expected frequency) Single-frequency and between 0.1-0.5N change be +/- 0.05N (such as variation≤0.05N) single force vibration.With software It is redesigned with power, makes to vibrate more stable, compliance increase, so that being further improved flat by what is observed in clinical test Remold speed.

Another method of the safely and effectively orthodontia power and frequency that keep constant includes providing processor to control Weight vibrating motor and battery are deviated to the processor and motor power supply；Adding on the processor and the motor Velocity sensor or encoder interface with；The speed of the motor is measured with the acceleration transducer or the encoder；And The speed of the motor is adjusted by the specialized voltages adjuster of pulsewidth modulation and the driving voltage of the limitation motor；Make Obtain the method for using step a-d includes the orthodontia remodeling device of vibration source outside mouth internal gearing plate and mouth in the biteplate By patient's occlusion and when described device is activated, to change the only single-frequency of 2Hz between 20-40Hz and in 0.1- The single force vibration for being +/- 0.05N is changed between 0.5N.

However, above-mentioned encoder design, which has, is increased in size moving parts with weight, and provide for device another A fault point.Therefore, design is further had updated herein.In new design, without any moving parts and with more Motor speed control is realized in the case where small component.Therefore, size and weight can be further decreased.

New motor control method makes connector away from motor using the pin connector for being placed on somewhere on circuit board or equivalent 0.01-5mm.These pin connectors show the field small electrostatic (ES), and when motor is mobile relative to pin, it, which will receive, is disturbed It is dynamic.The solid state sensor for being operably connected to pin connector can measure this disturbance, and thus may determine that motor revolves The speed for turning or otherwise moving.Motor speed then is adjusted similar to software described in other application, to provide Constant speed, or even under variable power.

Another selection is using accelerometer, and wherein MEMS piezoelectric element forms bridge, can detecte movement.It is such Device is commercially available for example from STMicroelectronics or Freescale (being now NXP Semiconductor).Another Selection will be using gyroscope, this is another method being adjusted, but this is a more expensive selection at this time.

Non-rechargeable battery or rechargeable battery can drive vibration source, wherein using from including USB port, RS- The electric power of any kind of power supply of 232 ports, wall-mounted DC converter or FireWire port carries out rechargeable battery Charging.Alternatively, described device can be inserted in any wall type pod.

Vibration is most commonly via the motor (offset motor) or pressure made with uneven or eccentric weight axis rotation Electric-type device provides, but can be used any other vibration component.The known method for generating vibration includes motor and cam Axis, motor and connecting rod, motor rack-and-pinion, motor and transmission belt and similar mechanical means.It is also possible, however, to use Solenoid vibrator, linearity coil vibrator, linear resonance actuator, voice coil actuator etc..Existing commercialization vibrating motor packet Include long-life brushless (BLDC) vibrating motor, coin (thin pancake) vibrating motor, encapsulation vibrating motor, pager motor, PCB installation Vibrating motor, centreless DC motor, ultrasonic motor etc..

Ideal vibration source will quietly, and can be combined with feedback mechanism, with accurately control vibration velocity and Power.In addition, its will be it is small, good working life is enjoyed with cost-effective price.

As shown in the table, a large amount of very small vibrating motor can be used, but due to small size, piezo-electric motor may It is preferred, and may be preferred from weight motor due to low cost and availability.It is particularly preferably substantially planar Motor, wherein vibration be arranged essentially parallel to substrate (for example, US5554971, US5780958, US20090224616, US20080129130, US20070103016, WO0178217, respective be incorporated by reference are incorporated to).

Vibration can be oscillation, random, oriented, circulation etc..Many vibrators are in the patent literature Description (and as shown above commercially available).For example, respective US20070299372 incorporated by reference, US20070255188、US20070208284、US20070179414、US20070161931、US20070161461、 US20060287620 describes various vibrating motors.

Battery can drive vibration source, especially for embodiment in mouth.Small Coin shape alkalinity or lithium battery due to Its small size but it is preferred, but since its pot-life, power and power density, especially size and cost are with technology It is further development and reduce, hydrogen battery is also likely to be preferred.Nickel metal hydride battery is preferred at present.

It can be preferred (example for longer life of product with the battery of wireless charging for certain embodiments Such as, US20090051312, US7511454), but in other embodiments, manufacture be intended to that single patient uses it is low at The present apparatus.Be known in the art select power supply/motor combination appropriate to provide in the frequency for being suitable for orthodontia remodeling and The orthodontia vibrator of power internal vibration.

Any ready-made on/off switch can be used.Particularly preferably there is depressible activation for Oral appliances The on/off switch of device (push button, rocking bar or membrane buttons).

Lease, rent or each program use or what any other was variable uses system and direct purchase system to make Vibration source or device outside mouth can be provided to patient with low cost.System can provide diagnostic message to service provider.System It also supports to make the outer vibration source recycling of mouth, although biteplate is it is intended that the component that single patient uses is also such.

On the other hand, described device transmits non-static power to change the tooth including jawbone, mandibular or maxilla Tooth tissue.Jawbone receives lasting non-static power (for example, vibration), is then passed to tooth component, and non-static power weight Mould the tissue of mandibular, maxilla or jawbone.Described device can be used for other kinds of maxillofacial applications and wound, as TMJ, Lefort wound Classification treatment program, tooth and other dental implants etc..

In other respects, by transmitting non-static power, realize that tooth is mobile and treatment is wrong by accelerating bone remodeling to cause Tooth conjunction, craniofacial abnormalities, bone defect and facing deformity；Mitigate the pain and discomfort of patient；And improve the long-term knot of tissue integrity Fruit, to recur after preventing orthodontic treatment.

The method and equipment include for data capture relevant to patient compliance and usage behavior and analysis and For the present invention to be established as the component part of clinical office workflow to improve efficiency the mechanism with productivity.

The advantages of system may include following one or more.System passes through the non-static power of application and enhances and accelerate traditional Orthodontic treatment process.According to system embodiment, accelerate mutually to tie with orthodontic treatment using non-static power The remodeling of the craniofacial bone of conjunction.System can be used for treating the tooth plate bite of form of ownership and classification, craniofacial abnormalities, bone defect or Jaw facial deformity, wherein bone remodeling plays physiological action.System can dedicated for maxilla, dedicated for mandibular or with double Arch mode (while maxilla and mandibular) uses.In addition, system can be used for treating present complete denture, it is natural or it is non-from Any combination of case of the tooth so lacked, and remold the bone in edentulous patients.It can treat any age and have any The patient of medical history data.System can take any kind of drug by patient and use.

System makes it possible to consider under wider bone remodeling background that orthodontic treatment and tooth are mobile.Orthodontia The mobile rate-limiting step of tooth is ostosis.Compared with static force, dynamic load (cyclic force) leads to bigger ostosis or bone Growth/bone remodeling.Moving teeth is completed by the tooth socket craniofacial bone around remodeling.Bone remodeling is related to several steps.Firstly, (osteoclast activity) occurs for net bone resorption, and needs two to three weeks.Second, occur from be absorbed into only net formation (at Osteocyte activity) reverse.Finally, bon e formation fills cavity in three to four months.Osteoclast activity usually removes tooth shifting Dynamic path, than osteoblast floating packing, its speed is five to six times fast.Therefore, in order to accelerate to move, (bone is raw for bon e formation At) must accelerate.

Compared with basic dynamically load, such as 1 hertz of sine curve, certain dynamically load modes (for example, upper frequency and The insertion rest period) substantially increase bon e formation.The known insertion rest period is particularly effective, because it allows mechanical sensitivity It is restored to bone tissue.Decreasing returns point is reached within each load time of the meeting.Therefore, cyclic force interval load and to upload and can show It writes and increases bone formation rate.

System realizes the effective but quick treatment cycle for being related to quickly changing the power on tooth.It does so without inciting somebody to action Piezoelectric current is introduced into the bone by mechanical stress.It is used by computer monitoring and significantly enhances the compliance of patient.It controls It treats result and directly depends on the precision that patient follows the instruction of health care professionals.When system can wear scheduled Between, such as once a day about 20 minutes or more long or any other suitable duration, therefore patient can be at home Wearable device continues the appropriate wearing duration.

Health care professionals, patient or parent/guardian can measure the patient compliance occurred between agreement And use pattern.It measured compliance and applies storage in electronic component, and can be retrieved by health professional；Including On the internet, it is retrieved by smart phone/intelligent apparatus or any other communication media.Health care professionals can Directly compliance information to be downloaded in ready-to-use market practice software package.

System supports a kind of business model, allow the non-disposable component of orthodontic treatment variable and cost with control It is proportional to treat the duration.Device can be disposable or non-disposable.Device can be on the operation basis for patient On directly or by orthodontist or third party lease, rent or purchase.The system proposed also adds orthodontia case Treating capacity, and to improve office efficiency.

In more detail, the present invention is a kind of orthodontia remodeling device comprising has the occlusal surface for contacting tooth Substantially U-shaped cross section surface mouth internal gearing plate, the U-shaped biteplate have outer ledge, the outer ledge have it is upper Edge and lower edge are to contact the upper surface of tooth and gum portion surface and lower face surface；The U-shaped biteplate has inner side edge Edge, the inside edge have optional top edge and lower edge with the upper lingual surface for contacting tooth and gum and lower lingual surface at least A part.There are also waterproof shells outside mouth, described it includes the rechargeable battery for being operably linked to vibrator (actuator) Vibrator is operably linked to for capturing the processor for using data, and the processor is operably linked to data and fills Electric port, the data and charging port are used for transmission the data and charge to the battery.Shell can also have wherein Have for accessing the data and charging port rather than the access mouth of the battery or processor.U-shaped occlusion reversibly and It is operably connected to the shell, and device is maintained at appropriate on biteplate by tooth clamping during use Position, and do not have other head attachment members.This feature is especially important for compliance, because of dental aligners Do not like for children and adult generally.

In another embodiment, described device is a kind of orthodontia remodeling device comprising is had for contacting tooth The mouth internal gearing plate on the substantially U-shaped cross section surface of tooth occlusal surface, the U-shaped biteplate have outer ledge, the outer side edges Edge has top edge and lower edge to contact the upper surface of tooth and gum portion surface and lower face surface；The U-shaped biteplate tool Have an inside edge, the inside edge have top edge and lower edge with the upper lingual surface for contacting tooth and gum and lower lingual surface extremely Few a part；The outer waterproof shell of mouth, it is described it includes the rechargeable battery for being operably linked to vibrator (or actuator) Vibrator is operably linked to processor, and the processor is operably linked to USB port；The shell also has wherein Have for accessing the USB port rather than the access mouth of processor or battery, access mouth system are connected to the shell；It is described Battery and/or access mouth can only be accessed with tool；The U-shaped biteplate reversibly and is operably connected to the shell；Institute It states orthodontia remodeling device noise level when measuring under 6 inches and is less than 55dB, and can be with 20-40Hz and luffing Only the frequency of 2Hz and 0.1-0.5 newton and luffing are+power of -0.05N or similar frequency and force vibration；It is wherein described Device is held in place on biteplate by tooth clamping during use, and is not had other heads and be attached structure Part.

In another embodiment, described device substantially consists of the following parts: mouth internal gearing plate, has for connecing The substantially U-shaped cross section surface of the occlusal surface of tooth is touched, the U-shaped biteplate has outer ledge, and the outer ledge has Top edge and lower edge are to contact the upper surface of tooth and gum portion surface and lower face surface；The U-shaped biteplate has inside Edge, the inside edge have optional top edge and lower edge with the upper lingual surface for contacting tooth and gum and lower lingual surface extremely Few a part；The outer waterproof shell of mouth, it includes the charging port for being operably connected to rechargeable battery, the rechargeable Battery is operably linked to vibrator (or actuator), and the vibrator is operably linked to processor, the processor It is operably linked to data port；The U-shaped biteplate reversibly and is operably connected to the shell；The abnormal tooth is rectified Positive remodeling device noise level when measuring under 6 inches is less than 55dB, and can be only 2Hz with 20-40Hz and luffing Frequency and 0.1-0.5 newton and luffing be+power of -0.05N or similar frequency and force vibration.

In another embodiment, orthodontia device substantially consists of the following parts: the outer vibration source of mouth (or actuating Device)；The outer processor of mouth controls the outer vibration source of the mouth；Power supply drives the vibration source；Attachment in mouthful, by biteplate Composition, the biteplate permission is contacted with the occlusal surface of patient teeth and at least one of lingual surface and buccal surface, wherein stinging Described device is held in place by the patient on the biteplate during use；Wherein the outer vibration source of the mouth is connected to Attachment in the mouth；Wherein the orthodontia device is that isolation is sealed and can be vibrated with the frequency of 0.1-400Hz.

In another embodiment, orthodontia device substantially consists of the following parts: the outer vibration source of mouth (or actuating Device)；The outer processor of mouth controls the outer vibration source of the mouth, and captures and transmit frequency of use and duration；Battery, Drive the outer vibration source of the mouth；Attachment in mouthful, is made of biteplate, the biteplate allow with the occlusal surface of patient teeth with And the contact of at least one of lingual surface and buccal surface, wherein the patient stung on the biteplate during use protects described device Hold in place, wherein attachment is connected to the outer vibration source of mouth in mouth；Wherein the orthodontia device is isolation sealing；Its In when activated, the orthodontia device can be vibrated with the frequency of 0.1-400Hz.

In other embodiments, device is in complete mouth, and biteplate is also directly over as described herein With power supply, vibration source and processor, but it can be omitted processor in low cost device.Device should be isolation sealing Or otherwise waterproof, and therefore wirelessly rechargeable battery will be that preferred or long-acting battery can with low cost Device connection.Since intraoral space is limited, so coin vibrator or other micro-vibration devices may be best vibration source, It couples with such as membrane buttons off on switch, preferably can be by contact of grinding one's teeth in sleep.Placement of these electronic components on biteplate It can be cheek to contain or tongue button or occlusion, this depends on the size of component, it is preferred that be not labial surface (under lip), because It interferes use and beauty.

Additionally provide the method for orthodontia remodeling, including bite biteplate as described above, and activate vibrator about 5,10, 15 or 20 minutes or longer time.This can be daily, or preferably twice daily, or more frequent.Since device accelerates abnormal tooth Correction remodeling, so integral correction treatment time is reduced, such as averagely 2 years to 1 year.

When being used together in claims or specification with term " includes ", "one" use of words means one It is a or more than one, unless the context indicates otherwise.

Term " about " means if not indicating measurement method, the nargin of described value plus or minus measurement error or Person plus or minus 10%.

The use of term "or" refers only to substitute for meaning "and/or" unless explicitly indicating in detail in the claims What object or substitute excluded each other.

Term " includes ", " having ", " containing " and "comprising" (and its variant) are open connection verbs, and allow weighing Other elements are added when using in benefit requirement.

Wording " by ... form " it is enclosed, and do not include all additional elements.

Wording " substantially by ... form " eliminates additional material elements, but allows not change the present invention substantially The non-material elements of property include.Therefore, term " substantially by ... form " excludes such as such as the following element: huge rectifys Positive device is designed to that device is held in place part during use；Toothbrush bristle；Laser etc., this will be from basic The upper property and use for changing device.However, the wording will be not excluded for such as such as the following element: additional LED light；Quickly dial Dialer or other control buttons；Battery charge indicator；Attachment；It is engaged the variation of plate shape；Wiring variation or software；Processing Device or the variation of the communication technology etc..

As used herein, all terms are the dental uses according to standard.Therefore, buccal surface refers to the surface towards cheek, Lip refers to that tongue refers to towards tongue, and face includes labial surface and buccal surface surface towards lip.

" U-shaped " is here and hereinafter meant that biteplate follows the curvature of denture, such as the occlusal surface of tooth is in substantially U-shaped song Rate.

" ligulate " means that device is ligulate (for example, U as having been filled with), makes it possible to and serves as such as palatal expander Or retainer.

When our referenced herein contacts " tooth " or similar wording, it is intended that entire denture, such as the teeth of two arches Tooth.If being intended to be less than entire denture, by " part " of referred to as maxillary teeth, mandibular teeth or tooth, Huo Zhete Determining tooth or arch will identify by name.However, biteplate does not need to contact every single tooth, because according to definition, some mistakes Tooth conjunction may cause one or more teeth and significantly be misaligned.The phrase also allow to have on grinding one's teeth in sleep some leeway adapt to The lower fact: denture change in size, and if any, grinding one's teeth in sleep can break out between 20-25 years old, or can be removed with for Remaining tooth provides additional space, and therefore Most patients do not have a secondary complete adult tooth.It is therefore intended that The institute's biteplate dentulous for contacting average adolescent patients may not reach old or older patient or with more mature denture Patient grind one's teeth in sleep.

" treatment mode " means a kind of action mode for leading to orthodontia benefit.

" treatment mode source " means to provide the device for the treatment of mode or the component of device.For example, vibration is that orthodontia is controlled Treatment mode, and vibration source provides vibration.Vibration source is referred to as vibrator.Another tupe is infrared light or ultraviolet Light, and LED or laser can be exemplary light source.

" biteplate " means to wear the device for contacting the occlusal surface of tooth in the oral cavity and usually as used herein, makes Device is obtained to keep on biteplate by patient's " stinging ".

" mouth outer driver " is to provide the mouth exterior part for the treatment of mode, and is to have for example to control in preferred embodiments Treatment mode source (such as vibrator or laser, processor, battery or other power supplys) and described in being operatively coupled or operating The shell of wiring needed for source, and wherein shell has the pod of the connector for receiving port internal gearing plate.Shell is preferred Ground will be water-fast or waterproof.

" pod " means that hole or recess portion or interior not-go-end, outer not-go-end connector can assemble wherein.

For " shell ", it to be used for mouthful outer surface of outer driver component or a container.

" orthodontia remodeling " is consistent with the definition that its technical field receives to be used, and is referred to and be enough to mention in high-pressure side Still root absorbs minimum and carries out bone remodeling for osteoclast activity and in the case where depressurised side provides the movable power of osteoblast, makes It obtains tooth and gradually moves and/or realign desired position, and realign tooth.

" orthodontia power " is consistent with the definition that its technical field receives to be used, and is referred to needed for orthodontia remodeling That stablizes (static state) realigns power.Referring to micropulse.

" micropulse " is very small vibration or cyclic force, it is now known that abnormal tooth is caused to be rectified when in conjunction with orthodontia power Just remolding fast 50%.

" orthodontia remodeling utensil " or " orthodontic appliance " is consistent with the definition that technical field receives uses, and is Refer to that those provide orthodontia power and therefore carry out the device that tooth realigns.The term includes various devices, is such as supportted Frame, aligner, locator, Herbst, sagittal utensil, palatal expander, pendulum, Nance etc..The term does not include cleaning of teeth Device, such as electric toothbrush, or the burnisher scaler of profession etc..

" rectifier (Headgear) " is consistent with the definition that its technical field receives to be used, and is referred in certain party It can not be easily by the various neck attachment members of the orthodontia power of attachment point realization in mouth to providing.For example, it rectifys Positive device is possibly used for pulling downward on lower jaw to help to correct II class plate bite.

Detailed description of the invention

Figure 1A-B shows an embodiment of orthodontic treatment system, wherein electric component be all it is outside mouth and In shell.

Fig. 2A-B shows the second embodiment of orthodontic treatment system, wherein all components are all in mouth.

Fig. 3 shows the exemplary diagram for the control electronic device being used together with the system of Fig. 1-2.

Fig. 4 shows exemplary dental treatment network.

Fig. 5 shows the example process for treating patient.

Fig. 6 is shown for capturing data and providing data for feeding back the example process of purpose.

Fig. 7 shows the exemplary system for leasing, renting or buying utensil.

Fig. 8 shows the example process for improving office and case efficiency.

Fig. 9 is to compare appliance and pain degree difference and improved treatment time without using patient in the case of utensil Example process.

Figure 10 A-B shows the perspective view from the biteplate in terms of two angles, shows flat U-shaped base portion, Yi Jishang With sublingua and facial edge and bar, it is assemblied in the cooperation pod (not shown) on mouthful outer housing.

Figure 11 A and B shows the core of biteplate from two angles, is molded with thereon with edge and desired most end form The biocompatible covering of shape.

Figure 12 shows the top view of biteplate, clearly shows bar, opening portion, pin, cylindrical shaft and groove, Jump ring assembly with the respective recess (not shown) cooperation in pod is wherein.

Figure 13 A-B shows USB embodiment from two angles, and wherein USB is placed in the main body for being connected to shell Inside access mouth, and USB transmits two purposes with data for recharging.

Figure 14 A-B shows exemplary using datagraphic.Figure 14 A shows Graphic Design, on single figure Daily %, 30 days %, minute of use and time of the meeting number are provided.Bottom grey is had moveable using the small horizontal bar of data Cursor rolls icon (the small frame for referring to every one end), and user is allowed to select the data area to be checked.Therefore, patient, Parent/guardian or health care professional can check the history of whole wheat harvesting period or many years, or can pay close attention to nearest one month Service condition.Figure 14 B illustrate how by cursor (arrow) is transmitted in data select one day data (referring to Point) to be shown.The data of selected day are subsequently displayed in the abstract in the upper right corner.

Figure 15 A-C shows exemplary circuit diagram.

Figure 16 shows the power indicated in Y-axis with newton to the curve graph indicated in X-axis with Hz, and depicts to power With the various combined patient's reactions of frequency.In general, frequency is higher, it should which the power used is smaller in order to provide with good trouble The device of person's acceptance.

Figure 17 shows the pin connector on circuit board and the solid state sensors for sensing motor speed.

Figure 18 A-B shows the biteplate of not kernel, is molded on the outer activator appliance of mouth, and have for repairing The access mouth of electronic device.

Figure 19 shows the biteplate of not inner core, has notch in canine tooth surrounding, so that the end of grinding one's teeth in sleep of biteplate can With mobile relative to leading edge, to adapt to European, Asian and Damon arch.

Figure 20 shows the relationship of frequency Yu radian speed.

Specific embodiment

An embodiment according to the present invention, is accelerated and orthodontic treatment using non-static power (for example, vibration) The craniofacial bone remodeling combined.System can be used for treating tooth plate bite, craniofacial abnormalities, the bone defect of form of ownership and classification Or jaw facial deformity, wherein bone remodeling plays physiological action.System can dedicated for maxilla, dedicated for mandibular or with Double arch modes (while maxilla and mandibular) use.In addition, system, which can be used for treating, is presented complete denture, natural or non- Naturally any combination of case of the tooth lacked, and remold the bone in edentulous patients.It can treat any age and have and appoint The patient of what medical history data.System can take any kind of drug by patient and use.

Figure 1A-B shows an embodiment of orthodontia device 10.Device 10, which has, to be inserted into patient oral cavity Mouth internal gearing plate 20.Biteplate 20 is connected to the outer vibration source 30 of mouth.Device 10 is by the jaw 40 for the patient being clamped on biteplate 20 It keeps, to be fixed between dental arch 42.Other attachment devices are not needed, and therefore which strongly simplifies devices and trouble The comfort level of person, this is for greatly improving compliance.

Biteplate 20 can be interfaced with any part of denture 32, and be not limited to specific bow, region, quadrant or tooth, And it is not limited to natural dentistry or artificial limb denture, although our all teeth of contact described herein generally has Shape.Herein with regard to " all teeth " for, we mean biteplate from the tooth of distalmost end by arch up and under The most intermediate teeth contact of arch.However, due to plate bite, one or multiple teeth may be not in actual contact biteplate.If wrong Tooth conjunction is serious, then biteplate can be adjusted by removing and pasting standpipe, to contact the tooth of misalignment, or The biteplate of customization can be constructed.

The outer vibration source 30 of mouth in the present embodiment is activated by pressing the button being mounted in mouthful external equipment 38.Optionally Ground, vibrator can by with microprocessor 39 or by outside stimulus be transformed into apparatus function (including humidity or temperature sensing with And saliva content of mineral substances sensing) some other mechanism patient biting pressure sensing is activated for stimulation.

In more detail, the outer vibration source 30 of mouth includes vibrator or actuator 54, can be offset motor, piezoelectric vibrator Or any other component for generating vibration.Actuator 54 is operably linked to processor 39, and the processor can operate Ground is connected to battery 62.Mouthful outer vibration source 30 also as such as in a manner of be connected to biteplate: by what is generated by actuator 54 Power is transmitted to biteplate 20, and to be transmitted to the tooth and bone of user.The entire outer vibration source 30 of mouth is preferably enclosed in In shell (being not described in detail in this figure), be preferably watertight or at least water-fast.In addition, in this figure without detailed Wiring, software, connection, connector needed for description manufactures functional vibration source etc., but its various embodiments are in ability It is known in domain.

In the another embodiment shown in Fig. 2A-B, vibration source 30 is located in mouth, and biteplate keeps generating and applying Component needed for reinforcing.This embodiment can produce and apply non-static power to maxilla or mandibular arch or both.This is specific Embodiment is related to the double arcuate configurations to work together with two dental arch 40.Biteplate 20 is inserted into oral cavity and bitten away by patient, will Device 10 is stably maintained between tooth, but regardless of which arch 40 be device be activated to using.It is contained in a mouthful inner compartment Vibration source 30 in 36 is activated and pressing button 38 of activation actuator 54, causes entirely to be engaged panel vibration.Alternatively, It can be by being converted into some other mechanism of apparatus function for patient's biting pressure sense with microprocessor 39 or by outside stimulus It surveys as stimulation to activate vibration source 30.

Show the mouth inner compartment on the middle line and facing side of device, but it also may be embodied in tongue side, or can be with Such as in upper two or more vibrators of offer of grinding one's teeth in sleep.The entire isolated sealing of mechanism, so that its waterproof.

In one embodiment, when patient applies foot by biting device or otherwise jaw being clamped on device When enough power, device work.This enables a device to the offer of control loop power when applying the power of right amount.Implement herein In scheme, which includes 1) microprocessor and compliance software and reporting system；2) energy of the cyclic force of any level is provided Power；With 3) only when tooth applies correct power in equipment just provide cyclic force ability.Activation trigger device can also be with one Other a little stimulations are associated, including temperature or humidity sensing and saliva content of mineral substances sensing.

Fig. 3 shows the figure for the exemplary control electronic device being used together with device.Functional electromechanical component includes can To be the processor 39 of low power microcontroller.Processor 39 stores instruction and data in its memory 52.Processor drives Dynamic actuator 54, electric motor or piezo-electric device etc..The system of Fig. 3 receives energy from rechargeable battery 62.Processing Device 39 can be programmed or be updated by the communication port 60 of the USB port or wireless transceiver 58 that are such as connected to antenna 59 Or transmission data.Battery 62 can be any kind of, and can be the rechargeable type with craft port, is inserting It is charged the battery when entering battery.Processor 39 can also be communicated with optional sensor 64, to capture patient when needed Tooth data.Processor 39 can also simply transmit its operating parameter by communication port 60 or wireless transceiver 58, make It is equal to obtain such as dentist, orthodontist, clinical test monitor, medical orderly, treatment expeditor, staff, patient or third party It can according to need monitoring therapeutic advance.

Actuator 54 can be directly attached to biteplate or platform, as Fig. 2 mouth in shown in embodiment, or such as Fig. 1 The outer embodiment of mouth shown in.When activation, can have any shape or thickness and the biteplate that is made of any material or Platform is vibrated in a manner of transmitting necessary power.In preferred embodiments, biteplate includes solid inner core hard enough, with Vibration is transferred to tooth, for example, 30-40 Shore D, and covered by relatively soft biocompatible coating or shell, for example, 60-90 Shore A.

In other embodiments, inner core is omitted, and alternatively, biteplate is made of harder hardened material, example Such as, about 70-80 or 75 Shore As are being passed through bar and are being stung so that the vibration at shell and the vibration along biteplate midway are almost the same By the loss for being no more than 0.05N when plywood half.In such an implementation, bar must be sufficiently thick to allow and mouth exterior part Secured connection, but as an alternative, biteplate can be molded in above mouthful outer housing, so that connection is not problem.? In this overmolded embodiment, it may be desirable to there is the outer access compartment of mouth so that manufacture accessible electronic device into Row is repaired.Preferably, such compartment is not easy to be touched by user.As long as vibrating elements is fixedly attached to oral cavity part, we are right The test for omitting 3 kinds of different materials of inner core/frame not yet shows any reduction of power width.

For measuring force, biteplate is clamped on two sides to simulate and nibble, and force snesor is along biteplate midway The aperture being fed through in fixture, and the measuring force when device is activated.In activation also at the pod of mouth outer driver Measuring force.In the Current commercial embodiment with the rigid inner core made of polycarbonate, the power at pod is 0.28N, It and is 0.25N along the power of biteplate midway, and therefore loss is only 0.03N (~10%).It is interior to not having at us In the test of the biteplate of core, if motor weight will be modified correspondingly, still to stinging we have seen that loss is 15% Plywood transmits 0.2-0.25N.However, these experiments are not yet completed.

In order to increase power, there are 2 adjustable parameters: quality and acceleration.Acceleration is controlled by the radius * of weight. Quality selects (such as tungsten, steel etc.) and its size to control by the material of weight.

Eccentric rotating mass (ERM) is driven by small DC motor.Using ERM power (F) and rotation radian speed (ω), The radius (r) of the center of gravity of the quality (m) and weight of rotating weight is proportional.Formula is provided for effective (root mean square) power of application.

System will carry out the frequency of sensing power with the capacitance sensing of metal ERM, and therefore sense the vibration generated by rotation ERM It is dynamic.

Frequency=2 π ω

The relationship of frequency and radian speed

* radius=2 × offset, referring to fig. 20.

A principle for omitting inner core is the reduction of part and therefore reduces costs, but important advantage is possible to sting Plywood can be thinner, this provides increased comfort level, and user is also allowed to trim biteplate as needed to reach fitting Effect.Currently, biteplate is provided as six kinds of different sizes, and if expected biteplate with a thickness of 2mm or smaller, It can be reduced to 2 or 3 kind of different size, make it possible to and trimmed with scissors.

Other than the part of reduction and process time expense that have highlighted, in addition when rigid inner core is removed, sting Plywood and oral cavity part become more flexible.This allows us to design one " medium plane " (size is between size flat-size), It can accommodate all users, because it can bend into and (become smaller) or bow out and (become larger).This means that being reduced to a kind of size Oral cavity part.

In addition, if small wedge is cut out in the tongue side of biteplate at about each incisor, then adjustable sting The width of plywood so that adapt to each of European's arch, Asian's arch and Damon arch, mesh to be bonded in the oral cavity Preceding design is impossible in some aspects.Figure 19 shows this wedge, and since biteplate is for example by thermoplasticity Elastomer is made, such as medical-grade silicone, can be bent to conform to different arches at wedge with the smallest buckling.It moves After removing, biteplate will be returned to its original configuration.

Preferably, the outside of biteplate will not have unpleasant taste, and will be it is biocompatible, safe, And through Food and Drug Administration's approval, silicon rubber, polypropylene, HDPE etc..In another embodiment, mouth is contacted The occlusion plate coating of cavity tissue and the other parts of utensil can choose flavoring agent, to increase comfort in appliance. In another embodiment, described device is coated with polymer, and the polymer can be shaped again to be bonded for customizing, Such as boiling and occlusion polymer, or the polymerization that can be activated, solidify and/or fix by addition light and/or chemical substance Object.

Described device can have one or more interface points across denture, or can polymerize arch with entire denture simultaneously It is interfaced with in two arches.Be presented as the system of device described herein with the pulsation of about 0.1 hertz to about 1200 hertz of frequency or Vibration, but 1-400Hz is preferred, and especially 5-40Hz or 30Hz.

Also ultrasonic frequency can be used, because having some statistics indicate that ultrasonic wave is to the serviceability for accelerating bone remodeling.So And the successful use in dental applications is not yet asserted.In addition, the use of ultrasound may be pole so close at patients head Have it is irritating, therefore even if show ultrasound have skeletonization effect, but also such device is valueless.If patient does not use Device, then device may be without any effect.

In one embodiment, as discussed above, it can be passed daily with 0.1 to 400Hz frequency with the interface of denture Defeated about five newton (5N) insists on renewed treaty 20 minutes.However, less than 1 newton, the power of especially 0.1-0.5 or 0.2-0.3N are What patient more had a preference for, and have shown that it is clinically effectively and not cause root to absorb, if applying too big power Root absorption can occur.Excessive power usually enables patient unhappy, the high-tensile strength especially coupled with high-frequency, and is being preferably implemented In scheme, these parameters are adjustable in clinically-acceptable limit.Commercial apparatus uses always 0.25N, but this Sometimes 0.2N is rounded up in document.

Defined clinic power applies can be but right in the integrated mode of any duration, frequency and time of day Present apparatus is purged needle to carry out daily use in 20 minutes.After the activation duration for completing 20 minutes, device can To be automatically closed.Pace indicator in the form of audible tone, vision lamp, circulation stutter or certain other modes is mentioned to patient For the feedback about elapsed time, and the currently active can be also beneficial the interim remaining time.These indicators can be with It is any form and frequency.Indicator is presented as one second tone with five minutes intervals in first 15 minutes by prototype system, Tone when indicating five minutes, ten minutes and 15 minutes；And it was then the last one tone at 19 minutes, indicates user Remaining 60 seconds use time.Other indicators can be used and/or suitable treatment interval to provide notice to patient.Example Such as, professional can specify the treatment interval for being mixed and matched use pattern, to reach 20 minutes, such as 4X5 minutes or 10X2 minutes or its certain other combination.

After device closing, patient simply discharges biting pressure from mouth internal gearing plate, and removes device.With frequency of use Relevant real time data capture is updated with the duration.Therefore, compared with the same apparatus before the time of the meeting, after this data The device expression that phase uses will indicate an additional time of the meeting and other 20 minutes in using the duration.

In one embodiment, battery 62 is rechargeable, and can be inserted into its charger base between use Portion.Alternatively, battery 62 can be embedded in its shell by device, and whole device is placed in rechargeable base portion (or electricity Pond does not need to recharge).The charging of battery also can be used from the received electric power of USB port 60 and complete, and this is special Preferably.Therefore, charging port and data port can be identical port.Alternatively, any suitable calculating can be provided Machine or electrical connection to charge to battery.For example, battery can be used RS-232, Firewire or be hooked into capable charging by 5V.This Outside, the wall-mounted DC converter that standard can be used to charge to battery.

Provided that USB port, then should be protected inside housings, and via preferably connection or with certain Mode is attached to the access mouth of the main body of shell or detachable cover enters.It is excellent although not being necessary for operability Choosing, access mouth and battery can only be touched with tool, because this makes device safer and alleviates supervision burden.Optionally Ground can provide the USB port of waterproof, but this will increase cost.Preferably, battery and processor are also not patient and can touch And.

In a preferred device, described device uses induction charging, has substrate, and the substrate is arranged in device When thereon, charhing unit is contacted.It therefore, there is no need to cable, and manufacture water-tight device is easier in this way.

Described device be preferably completely cut off sealing to become airtight and watertight or at least water-fast, and can be with Withstand exposure to water or moisture.It can with and should store at room temperature.The battery 62 used in this specific embodiment Not only no memory, but also be Maintenance free.Device can have charger base portion, or the sufficiently long time can be inserted to fill Electricity uses for next time.

The application of cyclic force can be used for executing bone modeling and/or remodeling, and the case where no bone models or remolds The lower possible faster tooth occurred is mobile.Bone remodeling and the tooth of acceleration it is mobile across all types of displacements include: rotation, It translates, invade, squeeze and tumbles.This cause the acceleration remodeling of bone and tooth any plane (including it is horizontal and vertical, it is preceding and Afterwards, close to neutralize distal end and face (for example, cheek to lip) and tongue) in alignment it is related to movement.

By with the contact of denture (including any tooth, set of teeth or dental arch) or any type of interaction or by with support The contact of frame or aligner or locator can promote cyclic force to the transmitting of tooth and craniofacial bone.Interface can also include appointing What dental tissue, the tissue including tooth, enamel, dentine, cementum and dental pulp；And it can be any business or non-quotient The utensil of industry brand or design, especially aligner pallet.

Device can be used for any combination of mobile single tooth, entire denture or set of teeth.Tooth is passed due to this device The non-static power passed and be shifted, may include the natural teeth of no any dentistry effect；Natural teeth with dentistry effect Tooth, the dentistry effect include that the moral conduct of any property carried out with any material is restored, Guan Qiao is acted on；Through root canal treatment Tooth；Tooth through periodontal treatment；The tooth surrounded by the hard and soft tissue through periodontal treatment；And any kind of Dental implantion Body, including the miniature implant for orthodontia or the mobile purpose of tooth.The system proposed can with to any soft or hard Any kind of tooth or Maxillofacial surgery of the wound of institutional framework or treatment are used in combination.

System can be used in combination with any combination of tongue support, facial support or any quadrant across arch or both. It is also just contemplated to it is any based on robot or other lines bending optimisation technique it is compatible.System also with clearly aligner Technology treatment plan is compatible, includingTreatment method, regardless of whether having power attachment.

System can be used in combination with the new treatment since the first subtask for starting orthodontic treatment or it can Start to be treated with any time point over the course for the treatment of, until and including last clinical stage.

On the other hand, vibration dental apparatus can be with chemistry, biochemistry and the group in any current use or exploitation Weaver's journey treatment method is used in combination, to accelerate tooth mobile or remodeling craniofacial bone.These treatments may include growth factor, thin The adjusting of intracellular cytokine, matrix metalloproteinase (MMP), tissue inhibitors of metalloproteinases (TIMP) and extracellular matrix molecule. In addition, for relocating or stablizing tissue remodeling and/or angiogenesis substance can be applied to patient to promote around wait move Dynamic tooth or root carry out the remodeling of periodontium.Preferred substance will be in the tissue of fixing teeth or other cranio-orbital tumors In conjunction with and activate relaxin receptor.Most preferably the activity of relaxain or combinations thereof tissue remodeling is movable similar with angiogenesis Object or analogies.Analog includes peptide, oligomer, segment etc. comprising the active region of natural relaxain, and analogies include It is designed to simulate the active usually less than small-molecule drug of 2kD of natural relaxain.Alternatively, it can choose with main blood Pipe generates movable substance, VEGF, bFGF, estrogen, nitrous oxide, naltrexone etc..In addition, alternatively, clostridiopetidase A Or other organization softening enzymes can be used for that periodontium according to the present invention is promoted to remold.

Fig. 4 shows exemplary dental treatment network.Device 10 transmits operation and dentistry/doctor while being embedded in patient 1 Treat information.Data are received by native processor 99.Native processor 99 is further through communication on the wide area network 102 of such as internet Breath.Data can be received by the treatment professional of such as dentist or orthodontist in work station 120.Information can also be sent To one or more diagnosticians 130, they consult information, and are then pushed away by network 102 to treatment professional It recommends.The manufacturer 110 and the dentistry supplier 140 needed for any other that information is also sent to device.

The Internet community connection with one or more dentistry supply companies, service provider, manufacturer or marketer To network 102, and can be communicated indirectly with user's direct communication of client workstation 99 or by server 100.Mutually Connected community is that client workstation 99 provides the entrance of access orthodontia expert and dentist network.In addition, internet Community additionally provides the various support members of access, the entrance of finance company, leasing company and other service providers etc..

In another embodiment, device can send data to smart phone, therefore smart phone can remind user Use device, or third party can be transmitted data to and used for clinical test use, or by dentist or parent.

Although server 100 can be individual server, server 100 is also possible to the collection of redundant server Group.Such cluster can provide automaticdata standby, be protected to it to prevent hardware and software failure.In this ring In border, multiple servers provide resource independent of each other, until one of server fail.Each server can be held It is continuous to monitor other servers.When one of server cannot respond to, failure redundant process starts.The server of survival obtains The Shared Drive and volume of failed server, and the volume for being included on Shared Drive is installed.Use Shared Drive Application program can also start on survival server after failure redundant.Once between startup separator server and server Communication instruction server be ready for possessing its shared driver, then server starts recovery process automatically.Furthermore it is possible to Use server farm.Network request and server loading condition can be by server farm controller real-time trackings, and requesting can With cross-server field distribution, to optimize responding ability and power system capacity.When necessary, with the increase of flow load, field can be certainly The dynamic capacity for pellucidly making additional server is in service.

Server 100 can also be with protected by firewall.When firewall receives network package from network 102, determine Whether transmission is authorized to.If it is authorized, then firewall checks the header in package, to determine calculating using what encryption Method encrypts package.Using this algorithm and key, firewall decrypts data and the address of source and destination firewall, and by data It is sent to server 100.If source and destination both protected by firewall, on network it is unique it is visible (that is, not plus It is close) address be firewall address.Computer address on internal network and therefore the address of internal network topology is all Hiding.This is referred to as " virtual private net " (VPN).

System improves the compliance of patient, and the compliance is defined as device use/duration of wearing, device Using/wear frequency, device use/wearing time consistency, and correctly device use/wearing so that data with data Form is captured by device.Compliance refers to the instruction that patient is given according to health care professionals, will not excessively using and not Abundant use device.This data can check by health care professionals, as shown in Figure 5.In this embodiment, health care Professional provides the specification 510 for using and wearing to patient.Patient's use/wearable device, and during patient's use Capture the data 512 about compliance.After each treatment cycle, device is retrieved by professional, and therefrom extracts and complies with Property data 514.Data are presented 516 in the form of health care professionals will be allowed to carry out data analysis.As active feedback Then a part of process 518, health care professionals recommend device or re-define for subsequent use, until Access next time or interaction.This process can be related to some form of reward or be punished based on compliance and use pattern result It penalizes.Alternatively, device may be configured to that service condition is automatically passed to center, such as via smart phone, and And therefore near real-time monitoring will be possible.

As shown in fig. 6, for feedback purpose, data can also be supplied directly to patient or legal guardian.Device can be such as Configuration shown in Fig. 6 is actively or passively fed back with providing to patient user.This data generate and observation can be via using certain The request of the downloading of the electronic medium of form is to realize, or transmits during use as default setting.For example, in validity period Between, device can be according to request 612 or automatic 614 offer visual feedback from patient.Data can be downloaded 616 to such as In the electronic medium 620 of flash drive etc, and information can be sent to professional and feed back and analyze 618, Or it is transmitted directly to the legal guardian of patient or patient 619.

Fig. 7 shows the exemplary dissemination system of company 700, and wherein device 10 is hired out by orthodontia office 720 Or patient 730 is leased to, so that the time quantum of a part for allowing patient's expense to be used as treatment to device is proportional.Alternatively, Patient can be directly from commercial distribution tissue or manufacturer's lease or leased-out equipment, as shown in Figure 7.Patient can also rectify from abnormal tooth Just or health care professionals office 720 or commercial distribution tissue or manufacturer 700 buy utensil rather than lease or rent With device 10.

The another aspect of the system proposed is related to it and permits in orthodontia or other health care profession offices Perhaps and realize efficiency improvement.It can be used for reducing duration for the treatment of, increase NEW BEGINNING number, improve across any measurement Practice Corporate Performance, attract new patient, recruit previous treatment rejector, and improve and upstream or downstream reference or change the place of examination Any training or speciality dentistry/medical professional relationship.

Since patient uses system, health care profession efficiency is improved.This improvement may include that such as new case starts Quantity increase, the more short duration of total treatment time, the Chairtime for recalling or adjust the frequency or reduction that access Amount, as shown in Figure 8.In fig. 8, in the case where no device 810, orthodontia office is in office and case efficiency Stable state.As technology is using increase, and device is included into patient cases, the improvement of office and case efficiency It is achieved 820.These efficiency improvements can be used as any orthodontic treatment stage of any classification of malocclusion part or As a result and in the case where any arch wire or utensil type (including all sizes, shape and composition) occur.

Fig. 9 is shown for the patient that treats with and without invention device herein respectively Clinical effectiveness pain degree and integrality difference example process.Fig. 9 is shown due to use device, patient pain With the reduction of immoderation, and treatment time also substantially reduces and (according to compliance, reduces up to 50%).In Fig. 9, medical treatment Health professional treats the patient 910 of not the device of the invention, and professional observes or patient reports by treating The degree of pain and/or discomfort.Then, health care professionals treat patient with the device of the invention, and capture by controlling Treat the degree 920 of professional observes or patient reports pain and/or discomfort.It can analyze with or without device treatment Difference between the pain degree of patient.Device treats patient with less pain, and treatment results can be improved group Knit the form of integrality.Similarly, it has been suggested that treatment time improves up to 50%, and this horizontal benefit has been faced Bed verifying.

Figure 10 A-B shows improved biteplate 1000, with generally U-shaped base portion 1001, the base in contact tooth Occlusal surface, base portion has front and rear edges, one or two edge has face and the tongue surface of contact tooth/or gum Edge.Therefore, lingual margin 1002, lower lingual margin 1003, upper surface portion edge 1005 and lower face edge 1006 are shown.In this feelings Under condition, lingual margin only contacts incisor and/or canine tooth, but does not contact and grind one's teeth in sleep.However, the length at edge can change to contact tooth All or part of.Preferably, each tooth of at least one EDGE CONTACT, in addition to that specially designs is made for correction pole It spends except abnormal biteplate.

Bar 1008 is also showed that in Figure 10 A-B, is (not showing herein with the corresponding socket in mouth outer housing for biteplate 1000 The part cooperated out).In more detail, the fluted cylindrical shaft 1009 (referring to Figure 11) of tool is shown, ring 1010 is jumped and is assembled to Wherein, and with the corresponding pit in pod cooperate.Optional opening portion 1112 is also shown, and the opening portion is configured as Surface appropriate is provided, bar is pushed into pod by user.Due to this buckle between biteplate and mouth outer housing Mating feature, therefore biteplate can be reversibly attached to a mouthful outer housing, this realizes easier cleaning and/or storage.

The thickness of adjustable biocompatible covering material is (opening, deep, flat to compensate various patients' occlusion configurations Smooth), as being described in detail in US20100055634, which is incorporated herein by reference.However, most of In the case of, in distal end, the biteplate slightly thinner than intermediate ends will adapt to the hinged nature of remporomandibular joint and facial skeleton.

Therefore, if U-shaped biteplate, which has, can contact one or more distal ends or back teeth two rear ends, and In one or more close or front teeth front end and thickness E can be contacted, wherein the thickness E is 2-10mm, then stinging Plywood can be in one of following three kinds configurations:

A) thickness E is from the front end to rear end substantially constantization；

B) thickness E increases to the E at the rear end plus 0.5-10mm from the E from the front end；

C) E of the thickness E from the rear end increases to the E towards the front end plus 0.5-10mm.

We show bar on biteplate, but biteplate may include pod, and mouth exterior part may have There is bar.In addition, we have been illustrated with the cylindrical shaft (cylinder is clasped) with the jump ring around axis, as reversible One example of connection mechanism, but any reversible coupling mechanism can be used, including cantilever beam is clasped, spherical clip snap fit It closes, depressible push pin with pod, the screw fit that can be screwed togather etc..

Figure 11 shows the core 1007 of biteplate, usually by with the hardness harder than outer surface resin, metal or Ceramics are made, and provide enough rigidity for bar 1008, to be assembled in pod with allowing its locking.Cylindrical shaft 1009 has There is groove 1113, jumps ring 1010 and be fitted into them.In addition it is characterized in locking pin 1011 and orientation pin (not shown), prevents from stinging Plywood turns upside down insertion.Usual core uses the plastics of at least 40 Shore Ds, but metal or ceramics also can be used.Coating mentions For on this core, and the final shape of biteplate is provided, as shown in Figure 10.This coating should be the biology of 40-70 Shore A Compatible flexible polymer, and the transparent silicon resin of particularly preferably medical grade.

Figure 12 shows the plan view from above of biteplate, clearly shows core 1007, axis 1009, opening portion 1112, the other edge of pin 1011 and jump ring 1010 and external coating, provides the true form of biteplate.

Figure 13 A-B shows the whole device including biteplate 1000 and mouth exterior part 2000.Mouth exterior part includes shell 2001, it is ergonomically to be shaped with aesthetics, and there are on/off switch 2005, such as membrane buttons and LED light 2006.Preferably, LED and on/off switch are included in identical film, are manufactured because this simplifies and are improved reliability.

Inside housings be battery, processor and vibrator, it is as described herein and do not retouched in detail in Figure 13 A-B It states.Also show by tethers 2004 be connected to shell main body access mouth or nut cap 2002.This can prevent nut cap from losing. " tethers " herein means any type of attachment, including hinge or spiral rope.In access mouth, it can be seen that USB connector 2003, it is used for transmission data and allows to charge to rechargeable battery, the rechargeable battery is located at enclosure interior And patient is untouchable.

In preferred embodiments, access mouth can only use tool open, such as cooperate hook via small recess portion and cantilever snaps Pawl.This is preferably as avoiding the requirement of certain IEC 60601 which reduce supervision burden.It is also preferred that patient It touches less than battery, if when/battery needs replacing, it is necessary to return to manufacturer.This configuration is desired, because further Supervision burden is reduced, the risk of static discharge (EDS) is reduced, and if also allowing manufacturer's reset system and working as/electricity Pond provides any desired renovation when replacing.Additionally, it is contemplated that battery continues during entire treatment, and seldom need replacing electricity Pond.

Processor collect it is original use data, including the date and use the time.It include a certain amount of java code in chip, USB is converted into virtual flash driver, but any suitable code can be used.Therefore, when inserting the device into computer, Initial data is converted into suitable figure by code, as shown in figures 14 a-b.Show date in x-axis, shown in y-axis use (% according to It from property, minute of use and access times, is all indicated with same scale).For x-axis equipped with scroll bar, this allows practitioner's root More carefully data (for example, expansion time scale) is checked according to needs.

Show that (top line does not include daily makes for daily usage amount (maximum-norm data) and 30 days average routine use amounts With), minute of use (medium line) and access times (most downlink).Summarizing the service life below chart uses data.In this feelings Under condition, the daily use device of patient once or twice, is skipped a couple of days, and overall compliance is 94%.

When mouse passes through data, being given under selection mouse is fixed the date (referring to the point in Figure 14 B) and the data of that day It is shown in upper right side.

These figures are unavailable on the device for not having flash drive, and therefore will not be diverted or be covered by patient Lid.On the contrary, initial data is converted into available form when insertion and when activating by insertion a small amount of code in the processor.This permits Perhaps the smallest occupied area reduces supervision burden, and still provides the analysis of convenient data in a variety of manners, this can by from Dealer simultaneously uses in clinical test.The JavaScript code from open source software packet is used in our prototype, referred to as " dygraphs JavaScript visualizes library " (referring to code.google.com/p/dygraphs/), but also can be used Any other code.

The external source that setting time and data need to be communicated with device on prototype plant.It is a device to be connected to In the case where people's computer, user, which will navigate, arrives compliance data report, and the report opens display user using its browser Dynamic file saves the instruction of operation, this is by access product F LASH driver and input file title is to save such as " when the date Between ".Compliance on product F LASH driver can be reported and is stored under given filename by browser.Product will use text Part, which saves in operation, is arranged the real-time clock in device by the file creation date of operating system offer.

Be applied to biteplate, in tooth positioner or other mouthfuls the cyclic force of function utensil or the frequency of vibration be 1 to 1000Hz (preferably 10-100Hz, most preferred 20-40Hz) and power are 0.01-2 newton (or 0.1-0.5 or 0.2 newton), Duration is 1-60 minutes, preferably about 1-30 or 1-10 minutes or 20 minutes.It is convalescence, range 2-24 after this Hour, preferably 4-12 hours, and repetitive cycling is until successfully moving one or multiple teeth.

More specifically, orthodontic appliances of the invention have vibration source, the vibration source can be with 20 to 40Hz or 30Hz Frequency and the power of 0.1-0.5 newton or 0.25 newton vibration force is provided.Excessive power usually enables patient unhappy, especially with The power of high-frequency coupling.

This shows in the chart of Figure 16.It illustrates higher frequencies and power how to change perception of the patient to device. The chart is shown, for the comfort level of patient, 30Hz frequency should be coupled with the power less than 1 newton, but higher power can Cosily to use at a lower frequency.Fortunately, research also demonstrates, the power of very low magnitude will be enough to significantly affect abnormal tooth Correction remodeling rate.

Although at least one research has shown that hip bone density increases under 1Hz (walking speed), show lower frequency Rate may have curative effect, but need further work to illustrate the optimum frequency of orthodontia application.Further, since dentistry The different biological of structure, the optimum frequency that the result suitable for long skeletal bones frame structure may be applied with orthodontia have very big It is different.

In preferred embodiments, these parameters are that patient is adjustable in clinical effective range.In addition to capturing and depositing Using except data, processor can be with control force and frequency parameter, and can provide it control appropriate or user for storage Interface.

Preferably, vibration component has more stable vibrator, changing with reduced sound and low variation frequency and power Kind performance characteristics.Specifically, the noise level that improved vibrator is measured at 6 inches is less than 55dB, frequency 20- 40Hz, changing is only 2Hz, and power is 0.1-0.5 newton, is changed for+- 0.05N or similar.

The consistency of frequency and power is realized via feedback loop herein, wherein monitoring motor speed, and software root According to needing to adjust motor.More specifically, motor includes integrated encoder, the integrated encoder is every turn motor rotation provide it is multiple High and low signal output.Software counts the time between each encoder event (for example, can optically sense thereon with mark The rotating disk of note), and this is compared with desired target (for example, 30Hz).Compared based on this, then software adjusts The pulsewidth modulation of drive motor keeps desired speed optionally to increased or decrease speed.Accurate control speed also controls Power.

As a type of rotary encoder, integrated optics encoder be can be preferably, but feedback mechanism can be with It is any of technology.Encoder can be individual or integrated, and be optics, magnetism or capacitance-type encoder, or Person is again proximity sensor of the purposeization for coding.Proportional-integral derivative controller (PID controller) is another choosing It selects.PID is the general controls loop feedback mechanism for being widely used in industrial control system.

The known DC 5V motor with offset weight and 8 line integrated encoders provides these characteristics, but many other vibrations Dynamic device can also provide these performance characteristics, and can easily test it.MicroMo Inc. for example with 8 and 16 integrated line coding devices of the micro motor that can be used under various voltages, and many other suppliers also manufacture it is similar Device.Preferably, battery is chargeable lithium ion or polymer chemical products, and minimum capacity is 100mA- hours.

The device of customization can also be constructed, but ready-made component is relatively inexpensive.It is preferred, therefore, that motor is NMB The SE8G series DC motor of Technologies.Preferably, battery is the 110mAh of (601522) Fullriver Battery Li-PO battery.

Exemplary circuit diagram is provided in Figure 15 A-C.One embodiment is described below.

Processor: circuit controls vibrating motor, USB interface and user interface using 32 low-power processors.Processing Device is interfaced to EEPROM or external series flash memory, for storing and retrieving using data.Processor also with digital 3-axis acceleration Sensor interfaces with, and the sensor does not use at present, but can be used for the version in future, for monitoring using data and safety prison The device of control is orientated and vibration characteristics.

Power: power circuit is charged for battery using battery charging management controller and monitors the charged state of battery.Electricity Cell voltage is adjusted to 3.3V.

Motor control: motor speed is adjusted via the low side transistors switch of pulse width modulation controlled using by processor (pulsewidth modulation or PWM are the modulation techniques for correctly controlling pulse width based on modulator signal information, are formally arteries and veins The duration is rushed, wherein being fed to load by opening and closing the switch between power supply and load with quick speed to control The average value of voltage (and electric current) be supplied to the function of load so that the time switched out is longer compared to switch off-time Rate is higher).Motor speed is detected by processor by digital signal of the monitoring from reflective optic breaker, the reflection Formula optics breaker detects the transformation being attached on the notch wheel of motor drive shaft, and then carries out speed adjustment using PWM.To subtract Danger caused by light motor rotary speed is excessive, motor driving voltage is limited in 1.2V by specialized voltages adjuster, thus by maximum horse The level of a safety is limited in up to revolving speed.In addition, if failure is detected, then processor can disable voltage regulator.

User interface: user interface circuitry drives the LED current controlled by processor.Button press state is supervised by processor Depending on.

Taper bundle device (SIRONA^TMGALILEOS^TM) it is used for two roots of precise measurement, and estimate any acquired Root absorb, the imaging in all three planes (sagittal, axial direction and coronal view).Research is designed to determine whether to occur to appoint The root what is greater than 0.5mm absorbs or whether root long degree changes, and loses that discovery is not significant.

Research also measures interdental distance using digital calipers.Calculated during alignment stage first five tooth (on Under and) between overall distance, indicated with millimeter.Directly measurement is due to interdental gap caused by extracting.During research Moving integrally rate is weekly 0.526mm, higher than the average movement of no device.

We conclude that equipment safety increase the mobile rate of orthodontia tooth, and can with it is fixed Orthodontic appliance or transparent aligner are used together, and provide flexibility.Combination in view of orthodontic treatment is available, especially Because some patients are had and are treated in combination using fixed orthodontic appliance and transparent aligner treatment, this is useful 's.20 minutes short-term routine uses provide an advantage for patient.

45 patients carry out 3 phase randomized clinical trials, are carried out again with 25 grams and 30Hz.The primary efficacy endpoint of research is The difference of tooth rate travel weekly between device group and simulation control group.

The result shows that device as described herein can increase tooth movement when being used in combination with conventional orthodontia Rate.As a result confirm orthodontic treatment it is initial alignment (2.06 times of fast or fast 106%) and space closure (1.38 times fastly or The tooth that period accelerates fast 38%) is mobile.The overall therapeutic time has been fastly 50%.

Use device does not increase the risk that root absorbs or TAD loosens.Occur in a more than case in this clinical test Unique potential instrument dependent event and tooth it is uncomfortable, ache or numbness is related, all these events lead to the abnormal tooth of working standard Corrective therapy report.In all cases, event is all slight and of short duration event, and needs to stop treatment journey without event Sequence carries out material alteration to treatment procedure.Total satisfaction and eight specific assessments show that patient receives treatment well, And its daily routines easily is included in the use of device.

The direct clinical benefit of routine use device is to shorten treatment time.In the case where extracting space is 6-8mm, Device will be that patient saves 11-15 weeks during the space close stage of orthodontic treatment.However, it is contemplated that the alignment stage phase Between the mobile acceleration of tooth, the reduction of overall therapeutic time is possibly even bigger.The further improvement of overall compliance also may be used It can increase the whole acceleration observed.

Figure 17 shows the pin connectors 1701 and solid state sensor 1703 of the electrostatic or capacitance sensing that allow motor speed. Such as one or more pins of Arduino pin are attached on plate, and are welded or be otherwise operably connected to solid State sensor 1703.When capacitive load (being eccentrically rotated weight 1709 of such as motor 1707) and pin close to when, sensor inspection Capacitor is measured to transmit with eccentric rotating mass or ERM 1709 close to pin and change.It, can by tracking these variations at any time It to calculate motor speed, and the specification according to as defined in this paper, is adjusted, so that motor rotary speed is constant.The pin connector of customization It can be made of substantially any conductive material, be sensed with the pin using customization to maximize.

According to the size of the sensitivity of system and component, the distance D of pin distance ERM can be differed from 0.01mm to 5mm. Sensor detects the ability of target and determines by the size of target, dielectric constant and at a distance from sensor.Target size is bigger, visits Capacitive coupling between head and target is stronger.Material with high dielectric constant is easier to examine than the material with lower value It surveys.It is typically constructed of metal in view of ERM, dielectric constant is actually infinity, to provide remarkably for capacitive system Sensing function.The distance between target and probe are shorter, and the capacitive coupling between probe and target is stronger.

Ideally, pin is close, but is not very close to so that they can always be touched, even if device It is pushed out or falls.Distance can be from 0.05-2mm etc., it is therefore preferable to 0.1-0.5mm.We and 1 pin, electricity herein PCB is used in combination in capacity sensor and ERM motor.Processor 1711 for this is Cypress PSOC42xx CY8C4248LQI-BL483ES, but any customization or ready-made equivalent can be used.Identical processor can be used for Institute on device is functional, can also provide individual processor.Herein, we use Cypress PSOC42xx CY8C4248LQI-BL483ES reduces size.

Required software is comparatively simple.Time between signal disturbance determines speed, and software can increase motor Voltage is to accelerate speed, and vice versa.Software can be provided separately, or more or less be integrated in proximity sensor component Together.Ready-made programmable part can be used for capacitance type sensing, or can construct the device of customization, and can add thereto Add dedicated programming.

Herein it may be preferred that programmable system level chip (mixed signal Programmable Embedded system controllerSeries, the controller haveCentral processing unit (" CPU ")).This dress Setting has 32 8-digit microcontroller units (" MCU ") subsystem, has programmable analog and programmable digital ability, low-power 1.71-V to 5.5-V operation, allow capacitance sensing, have section type liquid crystal display (" LCD ") driver, serial communication capacity, Timing and pulse width modulation capability, up to 36 general programmable input/output (" GPIO "), integrate bluetooth low energy communication and PSoC Creator design environment, the environment allow fairly simple programming and troubleshooting.

For close to sensing, above-mentioned PsoC chip has Cypress CapSense Sigma-Delta (CSD), it is said that its Similar optimal signal-to-noise ratio > 5:1 and water resistance are provided.Proximity sensor emits electromagnetic field or electromagnetic radiation beam (for example, infrared Line), and find the variation of field or return signal.Sensed object is commonly known as the target of proximity sensor.Different connects Nearly sensor target needs different sensors.For example, condenser type or photoelectric sensor are likely to be suited for plastic target；Inductance type Proximity sensor always needs metal target.

By CapSense Sigma-Delta (CSD) block, can be supported on all pins of PSoC 4200 CapSense sensor, the block can be connected to any pin by analog multiplexer bus, and any GPIO pin is all The bus can be connected to by analog switch.It therefore, can any pin or pin in system under software control CapSense function is provided in group.A component is provided for CapSense block, user is made to become convenient.

The maximum distance that this sensor can detecte is defined as " nominal range " of definition.Proximity sensor has height can By property and long functional lifetime, because of the physics that machine components are not present and do not have sensor between the object that senses Contact.

GPIO is the common pin in integrated circuit, is showed (including either input pin or output pin) At runtime by software control.

It helps us to reduce another of plant bulk to be characterized in ERM using lesser offset weight.By a large amount of Research, we have found that, 87% tungsten weight is 1.9g, can be used for size reducing > 50%.In fact, when using 1.9g When 87% tungsten weight, the size total volume of motor is from 266mm³It is reduced to 109mm³。

Figure 18 A and 18B show the biteplate embodiment of not inner core, wherein increasing the hardness and/or motor of material Weight is to compensate any vibration damping by biteplate.In Figure 18 A, biteplate 1801 has the vertical table for contacting tooth The common vertical ridges or phalanx in face, and its shape is very similar to the biteplate of Figure 10.Therefore, not discussed herein each Kind surface and shape.Mouth outer driver 1803 with activator button 1807 can have somewhat greater pod 1808, larger Bar 1805 assembly wherein (or vice versa).Therefore, even if not firm inner core, the size of bar is also sufficient to securely Connection.Alternatively, bar can include harder material alone, or by harder material (not shown) it is overmolded with into The powerful connection of row.There is current configuration the bar 1805 being directly for good and all molded into pod 1808 to make in the fabrication process Its is non-dismountable.

In Figure 18 B, biteplate 1820 is molded on driver (not shown) or actuator housing 1823, therefore cannot It is separated.If desired, access mouth 1830 allows to touch electronic driver 1831, if it is desired, can remove it and right It is repaired.Driver 1831 is activated with on/off switch 1832.

Figure 19 shows another biteplate 1901 for not having inner core, have around canine tooth position notch 1903, 1905, the end of the notch permission biteplate closely together or separates as needed, to adapt to different arches.Such as this field As it is known that, European arch (referring to dotted line 1907) constantly narrows from grinding one's teeth in sleep to incisor, and Asian arch (dotted line 1909) it is closer to or in parallel from grinding one's teeth in sleep to canine tooth, and there is more circular front.It is suitble to all trouble accordingly, it is difficult to make The biteplate of person.However, huge stocks needed for dedicated biteplate are expensive, and space is needed to store.This is solved Scheme allows identical biteplate to adapt to wider arch, although certainly by there is still a need for children and adult size.Because Material is thermoplastic, it is possible to adapt to a degree of bending, and grind one's teeth in sleep and extend to adapt to European arch, and narrow To adapt to Asian arch.

Although the present invention is described in detail above, however, it is understood that not departing from such as by appended claim In the case where the technology of the invention defined, it can be variously modified, substitute and change.Those skilled in the art may Preferred embodiment can be studied and identified and not exclusively implement other modes of the invention as described herein.The present inventor Be intended that variant of the invention and equivalent within the scope of the claims, and this specification, abstract and attached drawing are not used to It limits the scope of the invention.The present invention is specifically intended to wide in range as the claims book and its equivalent.

The full content of each in following patent application is incorporated herein by reference for all purposes.

60/906,807 submitted on March 14th, 2007；The US20080227046 submitted on the 25th of August in 2014, US20080227047、US20100055634、US20120322018、US2013059263,US2013323669、 US2011136070,14/468,100；And on November 7th, 2013 submit 61/901,154.

Kau,C.H.“A novel device in orthodontics.”Aesthetic Dentistry Today 3: 6(2009):42-43。

Kau,C.H.“A radiographic analysis of tooth morphology following the use of a novel cyclical force device in orthodontics.”Head&Face Medicine 7:14 (2011)。

Kau, C.H., How et al., The clinical evaluation of a novel cyclical force generating devicein orthodontics,Orthodontic Practice 1(1):10- 15(2010)。

Kopher RA and Mao JJ.Suture growth modulated by the oscillatory component of micromechanical strain.2003.J.Bone and Min Res.18(3).pp.521-528。

Krishtab et al., [Use of vibratory action on the teeth to accelerate orthodontic treatment][Article in Russian]Stomatologiia(Mosk).1986 May-Jun；65 (3):61-3。

Nishimura et al., Periodontal tissue activation by vibration:Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats.2008.Am J Orthod Dentofacial Orthop 133(4)pp.572-583。

Peptan AI et al., Responses of intramembranous bone and sutures upon in- vivo cyclic tensile and compressive loading.2008.Bone(42)pp.432-438。

Vij K. and Mao, JJ.Geometry and cell density of rat craniofacial sutures during early postnatal development and upon in-vivo cyclic loading.2006.Bone (38)pp.722-730。

Werner,Alison.“Acceleration by Vibration.”Orthodontic Products(2011): 31,35。

Claims (10)

1. a kind of orthodontia remodeling device, comprising:

A) the outer vibration source of mouth comprising:

I) actuator；

Ii) processor, the control actuator and capture and transmitting device use data；

Iii) power supply drives the actuator；

B) attachment in mouth, is substantially made of biteplate, and the biteplate allows and is engaged face contact and allows and patient's tooth The upper buccal surface and jowl face contact of tooth, wherein stinging the patient on the biteplate during use by the orthodontia Remodeling device is held in place；

C) vibration source is connected to attachment in the mouth；

D) wherein single-frequency vibration of the orthodontia remodeling device to be chosen to be between 0.1Hz and 400Hz, and its In when being used together 20 minutes with support or aligner daily, with without using described device patient compared with, described device adds Fast tooth is mobile；

Wherein the speed of the offset weight motor is controlled with capacitance type sensor, and the capacitance type sensor includes one or more A adapter pin, the adapter pin have the field weak electrostatic (ES), and when the offset weight passes through, the weak electrostatic field is broken Bad, the adapter pin is operably linked to solid-state ES field sensor, and the solid-state ES field sensor is operably linked to Processor wherein the processor detects the speed by the field ES being destroyed described in detection, and controls the speed So that the velocity variations are less than 2Hz.

2. the apparatus according to claim 1, wherein the actuator is offset weight motor and the offset weight horse The tungsten for being at least 87% up to upper offset weight.

3. the apparatus according to claim 1, wherein the biteplate is made of single thermoplastic material.

4. device according to claim 3 is located at wherein the biteplate has at the position near the canine tooth of patient A pair of notches in its tongue side, allow the end of grinding one's teeth in sleep of the biteplate be bent at least 1cm and mutually closer to or bending extremely Few 1cm and every it is farther.

5. device according to claim 3, wherein the single thermoplastic material forms the biteplate and is completely covered The outer vibration source of the mouth and wherein the offer access mouth in the single thermoplastic material, allow to touch outside the mouth and shake Dynamic source.

6. the apparatus according to claim 1, wherein described device between 1-400Hz single-frequency and 0.1-0.5 ox Single force vibration between.

7. the apparatus according to claim 1, wherein described device is between 20-40Hz and luffing is the list of ± 2Hz One frequency and between 0.1-0.5N and luffing be ± 0.05N single force vibration.

8. the apparatus according to claim 1, wherein described device is vibrated with 30Hz and 0.2 newton.

9. a kind of faster orthodontia remodeling procedure, comprising: a) make patient's use according to claim 1 or claim 6 institute The described device for the device stated wears support or aligner, and is engaged the biteplate；And described device b) is activated daily About 20 minutes, wherein the method provided fast 50% tooth movement compared with without using described device.

10. a kind of orthodontia remodeling device, comprising:

A) the outer vibration source of mouth comprising:

I) actuator comprising offset weight motor；

Ii) processor controls the actuator；

Iii) power supply drives the actuator；

B) attachment in mouth, is substantially made of biteplate, and the biteplate allows and is engaged face contact and allows and patient's tooth The upper buccal surface and jowl face contact of tooth, wherein stinging the patient on the biteplate during use by the orthodontia Remodeling device is held in place；

C) vibration source is connected to attachment in the mouth；

D) wherein single-frequency vibration of the orthodontia remodeling device to be chosen to be between 0.1Hz and 400Hz；

E) wherein it is described offset weight motor speed controlled with capacitance type sensor, the capacitance type sensor include one or Multiple adapter pins, the adapter pin have the field weak electrostatic (ES), when the offset weight passes through, the weak electrostatic field quilt It destroys, the adapter pin is operably linked to solid-state ES field sensor, and the solid-state ES field sensor is operatively coupled To processor, wherein the processor detects the speed by the field ES being destroyed described in detection, and the speed is controlled Degree is so that the velocity variations are less than 2Hz；And

F) wherein when being used together 20 minutes with support or aligner daily, compared with without using the patient of described device, institute Stating device accelerates tooth mobile.